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DS.d200
18466349
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DS.d201
18466352
[ { "id": "DS.d201.s0", "type": "", "text": [ "RAD001-induced growth suppression was associated with inactivation of downstream targets of mTOR, reduction in VEGF expression and microvessel density, inhibition of cell proliferation, up-regulation of p27 (Kip1) and down-regulation of p21 (Cip1/Waf1), Cdk-6, Cdk-2, Cdk-4, cdc-25C, cyclin B1 and c-Myc." ], "offsets": [ [ 0, 304 ] ] } ]
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"Q9QAX1" }, { "db_name": "UniProt", "db_id": "Q9WMX2" } ] }, { "id": "DS.d201.s0.e4", "type": "protein", "text": [ "p21" ], "offsets": [ [ 237, 240 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19002" }, { "db_name": "UniProt", "db_id": "O39927" }, { "db_name": "UniProt", "db_id": "O39928" }, { "db_name": "UniProt", "db_id": "O39929" }, { "db_name": "UniProt", "db_id": "O91936" }, { "db_name": "UniProt", "db_id": "O92529" }, { "db_name": "UniProt", "db_id": "O92530" }, { "db_name": "UniProt", "db_id": "O92531" }, { "db_name": "UniProt", "db_id": "O92532" }, { "db_name": "UniProt", "db_id": "P26660" }, { "db_name": "UniProt", "db_id": "P26661" }, { "db_name": "UniProt", "db_id": "P26662" }, { "db_name": "UniProt", "db_id": "P26663" }, { "db_name": "UniProt", "db_id": "P26664" }, { "db_name": "UniProt", "db_id": "P27954" }, { "db_name": "UniProt", "db_id": "P27955" }, { "db_name": "UniProt", "db_id": "P27956" }, { "db_name": "UniProt", "db_id": "P27957" }, { "db_name": 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"db_id": "Q81487" }, { "db_name": "UniProt", "db_id": "Q81495" }, { "db_name": "UniProt", "db_id": "Q81754" }, { "db_name": "UniProt", "db_id": "Q913D4" }, { "db_name": "UniProt", "db_id": "Q99IB8" }, { "db_name": "UniProt", "db_id": "Q9DHD6" }, { "db_name": "UniProt", "db_id": "Q9QAX1" }, { "db_name": "UniProt", "db_id": "Q9WMX2" } ] }, { "id": "DS.d201.s0.e5", "type": "protein", "text": [ "Cip1" ], "offsets": [ [ 242, 246 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42923" }, { "db_name": "UniProt", "db_id": "P39689" } ] }, { "id": "DS.d201.s0.e6", "type": "protein", "text": [ "Waf1" ], "offsets": [ [ 247, 251 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P39689" } ] }, { "id": "DS.d201.s0.e7", "type": "protein", "text": [ "Cdk" ], "offsets": [ [ 254, 257 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O05982" } ] }, { "id": "DS.d201.s0.e8", "type": "protein", "text": [ "Cdk" ], "offsets": [ [ 261, 264 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O05982" } ] }, { "id": "DS.d201.s0.e9", "type": "protein", "text": [ "Cdk" ], "offsets": [ [ 261, 264 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O05982" } ] }, { "id": "DS.d201.s0.e10", "type": "protein", "text": [ "cyclin" ], "offsets": [ [ 284, 290 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O01377" }, { "db_name": "UniProt", "db_id": "O16852" }, { "db_name": "UniProt", "db_id": "P04961" }, { "db_name": "UniProt", "db_id": "P12004" }, { "db_name": "UniProt", "db_id": "P17070" }, { "db_name": "UniProt", "db_id": "P17917" }, { "db_name": "UniProt", "db_id": "P17918" }, { "db_name": "UniProt", "db_id": "P18248" }, { "db_name": "UniProt", "db_id": "P22177" }, { "db_name": "UniProt", "db_id": "P24314" }, { "db_name": "UniProt", "db_id": "P31008" }, { "db_name": "UniProt", "db_id": "P53358" }, { "db_name": "UniProt", "db_id": "P61074" }, { "db_name": "UniProt", "db_id": "Q00265" }, { "db_name": "UniProt", "db_id": "Q00268" } ] }, { "id": "DS.d201.s0.e11", "type": "protein", "text": [ "c-Myc" ], "offsets": [ [ 298, 303 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01109" }, { "db_name": "UniProt", "db_id": "P06646" }, { "db_name": "UniProt", "db_id": "P49709" }, { "db_name": "UniProt", "db_id": "P52160" }, { "db_name": "UniProt", "db_id": "Q17103" } ] } ]
[]
[]
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DS.d202
18467006
[ { "id": "DS.d202.s0", "type": "", "text": [ "A series of benzenesulfonamide-substituted 4-(6-alkylpyridin-2-yl)-5-(quinoxalin-6-yl)imidazoles have been synthesized and evaluated for their ALK5 inhibitory activity in cell-based luciferase reporter assays." ], "offsets": [ [ 0, 209 ] ] } ]
[ { "id": "DS.d202.s0.e0", "type": "compound", "text": [ "benzenesulfonamide" ], "offsets": [ [ 12, 30 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "7370" } ] }, { "id": "DS.d202.s0.e1", "type": "protein", "text": [ "ALK5" ], "offsets": [ [ 143, 147 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P36897" } ] } ]
[]
[]
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DS.d203
18468607
[ { "id": "DS.d203.s0", "type": "", "text": [ "Genetic variation in CETP (cholesteryl ester transfer protein) has been clearly associated with HDL cholesterol levels but its association with cardiovascular disease and related phenotypes has been more controversial, possibly due to variability of polymorphisms and their frequencies across different ethnic populations." ], "offsets": [ [ 0, 322 ] ] } ]
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[]
[]
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DS.d204
18470629
[ { "id": "DS.d204.s0", "type": "", "text": [ "However, methomyl exhibited more potency in reducing AChE activity than methiocarb." ], "offsets": [ [ 0, 83 ] ] } ]
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[]
[]
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DS.d205
18470874
[ { "id": "DS.d205.s0", "type": "", "text": [ "Early and late 2-cell and late 4-cell stage embryos, prepared by in vitro fertilization (IVF), parthenogenetic activation (PG), and nuclear transfer of mouse embryonic fibroblast (MEF) and mouse HM1 embryonic stem cells (HM1), were processed for autoradiography following (3)H-uridine incubation (transcriptional activity), transmission electron microscopy (ultrastructure) and immunofluorescence (nucleolar proteins; upstream binding factor, UBF and nucleophosmin, B23)." ], "offsets": [ [ 0, 471 ] ] } ]
[ { "id": "DS.d205.s0.e0", "type": "compound", "text": [ "uridine" ], "offsets": [ [ 277, 284 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6029" } ] }, { "id": "DS.d205.s0.e1", "type": "protein", "text": [ "UBF" ], "offsets": [ [ 443, 446 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P17480" } ] }, { "id": "DS.d205.s0.e2", "type": "protein", "text": [ "nucleophosmin" ], "offsets": [ [ 451, 464 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P06748" }, { "db_name": "UniProt", "db_id": "P07222" }, { "db_name": "UniProt", "db_id": "P13084" }, { "db_name": "UniProt", "db_id": "P16039" }, { "db_name": "UniProt", "db_id": "Q3T160" }, { "db_name": "UniProt", "db_id": "Q61937" } ] }, { "id": "DS.d205.s0.e3", "type": "protein", "text": [ "B23" ], "offsets": [ [ 466, 469 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P51472" } ] } ]
[]
[]
[]
DS.d206
18471929
[ { "id": "DS.d206.s0", "type": "", "text": [ "Furthermore, among the ROS scavenging antioxidant defense genes studied here, mRNA levels of salicylic acid-binding (SAbind) catalase (CAT) and lignin-forming peroxidase (POX) were found to be increased by proline and betaine under salt stress." ], "offsets": [ [ 0, 244 ] ] } ]
[ { "id": "DS.d206.s0.e0", "type": "protein", "text": [ "catalase" ], "offsets": [ [ 125, 133 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O24339" }, { "db_name": "UniProt", "db_id": "O52762" }, { "db_name": "UniProt", "db_id": "O62839" }, { "db_name": "UniProt", "db_id": "O68146" }, { "db_name": "UniProt", "db_id": "O77229" }, { "db_name": "UniProt", "db_id": "O93662" }, { "db_name": "UniProt", "db_id": "O97492" }, { "db_name": "UniProt", "db_id": "P00432" }, { "db_name": "UniProt", "db_id": "P04040" }, { "db_name": "UniProt", "db_id": "P04762" }, { "db_name": "UniProt", "db_id": "P07145" }, { "db_name": "UniProt", "db_id": "P0A323" }, { "db_name": "UniProt", "db_id": "P0A324" }, { "db_name": "UniProt", "db_id": "P0A325" }, { "db_name": "UniProt", "db_id": "P0A326" }, { "db_name": "UniProt", "db_id": "P0A327" }, { "db_name": "UniProt", "db_id": "P11934" }, { "db_name": "UniProt", "db_id": "P17336" }, { "db_name": "UniProt", "db_id": "P24168" }, { "db_name": "UniProt", "db_id": "P24270" }, { "db_name": "UniProt", "db_id": "P25890" }, { "db_name": "UniProt", "db_id": "P29422" }, { "db_name": "UniProt", "db_id": "P30265" }, { "db_name": "UniProt", "db_id": "P30266" }, { "db_name": "UniProt", "db_id": "P32290" }, { "db_name": "UniProt", "db_id": "P42321" }, { "db_name": "UniProt", "db_id": "P44390" }, { "db_name": "UniProt", "db_id": "P45737" }, { "db_name": "UniProt", "db_id": "P45739" }, { "db_name": "UniProt", "db_id": "P55304" }, { "db_name": "UniProt", "db_id": "P55306" }, { "db_name": "UniProt", "db_id": "P55310" }, { "db_name": "UniProt", "db_id": "P55311" }, { "db_name": "UniProt", "db_id": "P55313" }, { "db_name": "UniProt", "db_id": "P77872" }, { "db_name": "UniProt", "db_id": "P81138" }, { "db_name": "UniProt", "db_id": "P90682" }, { "db_name": "UniProt", "db_id": "Q27710" }, { "db_name": "UniProt", "db_id": "Q49XC1" }, { "db_name": "UniProt", "db_id": "Q4L643" }, { "db_name": "UniProt", "db_id": "Q59296" }, { "db_name": "UniProt", "db_id": "Q59337" }, { "db_name": "UniProt", "db_id": "Q59602" }, { "db_name": "UniProt", "db_id": "Q59714" }, { "db_name": "UniProt", "db_id": "Q5HG86" }, { "db_name": "UniProt", "db_id": "Q5HPK8" }, { "db_name": "UniProt", "db_id": "Q5RF10" }, { "db_name": "UniProt", "db_id": "Q64405" }, { "db_name": "UniProt", "db_id": "Q6G9M4" }, { "db_name": "UniProt", "db_id": "Q6GH72" }, { "db_name": "UniProt", "db_id": "Q7A5T2" }, { "db_name": "UniProt", "db_id": "Q8CPD0" }, { "db_name": "UniProt", "db_id": "Q8FWU0" }, { "db_name": "UniProt", "db_id": "Q8NWV5" }, { "db_name": "UniProt", "db_id": "Q8X1P0" }, { "db_name": "UniProt", "db_id": "Q8Y3P9" }, { "db_name": "UniProt", "db_id": "Q926X0" }, { "db_name": "UniProt", "db_id": "Q99UE2" }, { "db_name": "UniProt", "db_id": "Q9AXH0" }, { "db_name": "UniProt", "db_id": "Q9KW19" }, { "db_name": "UniProt", "db_id": "Q9L4S1" }, { "db_name": "UniProt", "db_id": "Q9M5L6" }, { "db_name": "UniProt", "db_id": "Q9PT92" }, { "db_name": "UniProt", "db_id": "Q9PWF7" }, { "db_name": "UniProt", "db_id": "Q9Z598" }, { "db_name": "UniProt", "db_id": "Q9ZKX5" }, { "db_name": "UniProt", "db_id": "Q9ZN99" } ] }, { "id": "DS.d206.s0.e1", "type": "protein", "text": [ "CAT" ], "offsets": [ [ 135, 138 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62839" }, { "db_name": "UniProt", "db_id": "O97492" }, { "db_name": "UniProt", "db_id": "P00432" }, { "db_name": "UniProt", "db_id": "P00485" }, { "db_name": "UniProt", "db_id": "P00486" }, { "db_name": "UniProt", "db_id": "P00487" }, { "db_name": "UniProt", "db_id": "P04040" }, { "db_name": "UniProt", "db_id": "P06135" }, { "db_name": "UniProt", "db_id": "P07641" }, { "db_name": "UniProt", "db_id": "P11504" }, { "db_name": "UniProt", "db_id": "P20074" }, { "db_name": "UniProt", "db_id": "P22782" }, { "db_name": "UniProt", "db_id": "P25309" }, { "db_name": "UniProt", "db_id": "P25819" }, { "db_name": "UniProt", "db_id": "P26825" }, { "db_name": "UniProt", "db_id": "P26826" }, { "db_name": "UniProt", "db_id": "P32796" }, { "db_name": "UniProt", "db_id": "P36882" }, { "db_name": "UniProt", "db_id": "P36883" }, { "db_name": "UniProt", "db_id": "P43155" }, { "db_name": "UniProt", "db_id": "P47934" }, { "db_name": "UniProt", "db_id": "P49417" }, { "db_name": "UniProt", "db_id": "P52826" }, { "db_name": "UniProt", "db_id": "P58777" }, { "db_name": "UniProt", "db_id": "P62577" }, { "db_name": "UniProt", "db_id": "P62578" }, { "db_name": "UniProt", "db_id": "P62579" }, { "db_name": "UniProt", "db_id": "P62580" }, { "db_name": "UniProt", "db_id": "P90682" }, { "db_name": "UniProt", "db_id": "Q00614" }, { "db_name": "UniProt", "db_id": "Q02736" }, { "db_name": "UniProt", "db_id": "Q03058" }, { "db_name": "UniProt", "db_id": "Q5RF10" }, { "db_name": "UniProt", "db_id": "Q64405" }, { "db_name": "UniProt", "db_id": "Q704S8" }, { "db_name": "UniProt", "db_id": "Q9M5L6" }, { "db_name": "UniProt", "db_id": "Q9PWF7" } ] }, { "id": "DS.d206.s0.e2", "type": "protein", "text": [ "peroxidase" ], "offsets": [ [ 159, 169 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15984" }, { "db_name": "UniProt", "db_id": "P16147" }, { "db_name": "UniProt", "db_id": "P84714" } ] }, { "id": "DS.d206.s0.e3", "type": "protein", "text": [ "POX" ], "offsets": [ [ 171, 174 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P07003" }, { "db_name": "UniProt", "db_id": "P37063" }, { "db_name": "UniProt", "db_id": "P92983" }, { "db_name": "UniProt", "db_id": "Q54970" } ] }, { "id": "DS.d206.s0.e4", "type": "compound", "text": [ "proline" ], "offsets": [ [ 206, 213 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "614" }, { "db_name": "PubChem", "db_id": "8988" }, { "db_name": "PubChem", "db_id": "145742" } ] }, { "id": "DS.d206.s0.e5", "type": "compound", "text": [ "betaine" ], "offsets": [ [ 218, 225 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "248" } ] } ]
[]
[]
[ { "id": "DS.d206.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d206.s0.e5", "arg2_id": "DS.d206.s0.e2", "normalized": [] }, { "id": "DS.d206.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d206.s0.e4", "arg2_id": "DS.d206.s0.e3", "normalized": [] }, { "id": "DS.d206.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d206.s0.e4", "arg2_id": "DS.d206.s0.e2", "normalized": [] }, { "id": "DS.d206.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d206.s0.e4", "arg2_id": "DS.d206.s0.e1", "normalized": [] }, { "id": "DS.d206.s0.i4", "type": "compound-protein-interaction", "arg1_id": "DS.d206.s0.e5", "arg2_id": "DS.d206.s0.e1", "normalized": [] }, { "id": "DS.d206.s0.i5", "type": "compound-protein-interaction", "arg1_id": "DS.d206.s0.e4", "arg2_id": "DS.d206.s0.e0", "normalized": [] }, { "id": "DS.d206.s0.i6", "type": "compound-protein-interaction", "arg1_id": "DS.d206.s0.e5", "arg2_id": "DS.d206.s0.e0", "normalized": [] }, { "id": "DS.d206.s0.i7", "type": "compound-protein-interaction", "arg1_id": "DS.d206.s0.e5", "arg2_id": "DS.d206.s0.e3", "normalized": [] } ]
DS.d207
18472163
[ { "id": "DS.d207.s0", "type": "", "text": [ "Significant ALP activity changes, sensitivity of isozyme patterns (Mr of 60, 64, and 85kDa) and increased variation in ALP plasticity during acute exposure to cadmium point to its possible aplication as an exposure biomarker." ], "offsets": [ [ 0, 225 ] ] } ]
[ { "id": "DS.d207.s0.e0", "type": "protein", "text": [ "ALP" ], "offsets": [ [ 12, 15 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P03973" }, { "db_name": "UniProt", "db_id": "P12547" }, { "db_name": "UniProt", "db_id": "P22298" }, { "db_name": "UniProt", "db_id": "P28296" }, { "db_name": "UniProt", "db_id": "P29118" }, { "db_name": "UniProt", "db_id": "P35211" }, { "db_name": "UniProt", "db_id": "P83610" }, { "db_name": "UniProt", "db_id": "P97430" }, { "db_name": "UniProt", "db_id": "Q03420" }, { "db_name": "UniProt", "db_id": "Q53GG5" }, { "db_name": "UniProt", "db_id": "Q9H0A0" }, { "db_name": "UniProt", "db_id": "Q9PU47" }, { "db_name": "UniProt", "db_id": "Q9Z1X0" } ] }, { "id": "DS.d207.s0.e1", "type": "protein", "text": [ "ALP" ], "offsets": [ [ 119, 122 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P03973" }, { "db_name": "UniProt", "db_id": "P12547" }, { "db_name": "UniProt", "db_id": "P22298" }, { "db_name": "UniProt", "db_id": "P28296" }, { "db_name": "UniProt", "db_id": "P29118" }, { "db_name": "UniProt", "db_id": "P35211" }, { "db_name": "UniProt", "db_id": "P83610" }, { "db_name": "UniProt", "db_id": "P97430" }, { "db_name": "UniProt", "db_id": "Q03420" }, { "db_name": "UniProt", "db_id": "Q53GG5" }, { "db_name": "UniProt", "db_id": "Q9H0A0" }, { "db_name": "UniProt", "db_id": "Q9PU47" }, { "db_name": "UniProt", "db_id": "Q9Z1X0" } ] }, { "id": "DS.d207.s0.e2", "type": "compound", "text": [ "cadmium" ], "offsets": [ [ 159, 166 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23973" } ] } ]
[]
[]
[ { "id": "DS.d207.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d207.s0.e2", "arg2_id": "DS.d207.s0.e0", "normalized": [] } ]
DS.d208
18472187
[ { "id": "DS.d208.s0", "type": "", "text": [ "To decrease the level of androgen testosterone in the prostate, we are interested in developing inhibitors of 17beta-hydroxysteroid dehydrogenase type 5 (17beta-HSD5)." ], "offsets": [ [ 0, 167 ] ] } ]
[ { "id": "DS.d208.s0.e0", "type": "compound", "text": [ "testosterone" ], "offsets": [ [ 34, 46 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6013" } ] }, { "id": "DS.d208.s0.e1", "type": "protein", "text": [ "17beta-hydroxysteroid dehydrogenase type 5" ], "offsets": [ [ 110, 152 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P42330" }, { "db_name": "UniProt", "db_id": "Q5R7C9" } ] }, { "id": "DS.d208.s0.e2", "type": "protein", "text": [ "17beta-HSD5" ], "offsets": [ [ 154, 165 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P42330" }, { "db_name": "UniProt", "db_id": "P70694" }, { "db_name": "UniProt", "db_id": "Q5R7C9" } ] } ]
[]
[]
[]
DS.d209
18472342
[ { "id": "DS.d209.s0", "type": "", "text": [ "A role for guanosine 3',5'-cyclic monophosphate (cGMP) and the protein kinase G (PKG) pathway in synaptic long-term depression (LTD) in the hippocampal CA1 region has been proposed, based on observations in vitro, where, for example, increases of (cGMP) result in short-term depression (STD) coupled with a reduction in presynaptic glutamate release." ], "offsets": [ [ 0, 350 ] ] }, { "id": "DS.d209.s1", "type": "", "text": [ "Application of an inhibitor of soluble guanylate cyclase prevented LTD induced by low-frequency stimulation (LFS), and impaired LFS-STD elicited in the presence of Zaprinast." ], "offsets": [ [ 351, 525 ] ] } ]
[ { "id": "DS.d209.s0.e0", "type": "compound", "text": [ "guanosine 3',5'-cyclic monophosphate" ], "offsets": [ [ 11, 47 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "24316" } ] }, { "id": "DS.d209.s0.e1", "type": "compound", "text": [ "cGMP" ], "offsets": [ [ 49, 53 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "24316" } ] }, { "id": "DS.d209.s0.e2", "type": "protein", "text": [ "protein kinase" ], "offsets": [ [ 63, 77 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P00513" }, { "db_name": "UniProt", "db_id": "P25848" } ] }, { "id": "DS.d209.s0.e3", "type": "compound", "text": [ "cGMP" ], "offsets": [ [ 248, 252 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "24316" } ] }, { "id": "DS.d209.s0.e4", "type": "compound", "text": [ "glutamate" ], "offsets": [ [ 332, 341 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "611" }, { "db_name": "PubChem", "db_id": "23327" }, { "db_name": "PubChem", "db_id": "33032" } ] }, { "id": "DS.d209.s1.e0", "type": "protein", "text": [ "cyclase" ], "offsets": [ [ 400, 407 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O94303" }, { "db_name": "UniProt", "db_id": "P33734" }, { "db_name": "UniProt", "db_id": "Q9P4P9" }, { "db_name": "UniProt", "db_id": "Q9SZ30" } ] }, { "id": "DS.d209.s1.e3", "type": "protein", "text": [ "STD" ], "offsets": [ [ 483, 486 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P50234" }, { "db_name": "UniProt", "db_id": "P52842" }, { "db_name": "UniProt", "db_id": "Q06520" } ] }, { "id": "DS.d209.s1.e4", "type": "compound", "text": [ "Zaprinast" ], "offsets": [ [ 515, 524 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5722" } ] } ]
[]
[]
[ { "id": "DS.d209.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d209.s1.e4", "arg2_id": "DS.d209.s1.e3", "normalized": [] } ]
DS.d210
18473163
[ { "id": "DS.d210.s0", "type": "", "text": [ "beta-Hexosaminidases (EC 3.2.1.52) are lysosomal enzymes that remove terminal beta-glycosidically bound N-acetylglucosamine and N-acetylgalactosamine residues from a number of glycoconjugates." ], "offsets": [ [ 0, 192 ] ] } ]
[ { "id": "DS.d210.s0.e0", "type": "protein", "text": [ "beta-Hexosaminidases" ], "offsets": [ [ 0, 20 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O60502" }, { "db_name": "UniProt", "db_id": "P44955" }, { "db_name": "UniProt", "db_id": "P49010" }, { "db_name": "UniProt", "db_id": "P58067" }, { "db_name": "UniProt", "db_id": "P75949" }, { "db_name": "UniProt", "db_id": "P96155" }, { "db_name": "UniProt", "db_id": "P96157" }, { "db_name": "UniProt", "db_id": "Q04786" }, { "db_name": "UniProt", "db_id": "Q0TR53" }, { "db_name": "UniProt", "db_id": "Q2KXM7" }, { "db_name": "UniProt", "db_id": "Q2P4L0" }, { "db_name": "UniProt", "db_id": "Q2Y863" }, { "db_name": "UniProt", "db_id": "Q31G32" }, { "db_name": "UniProt", "db_id": "Q31ZG4" }, { "db_name": "UniProt", "db_id": "Q32EW7" }, { "db_name": "UniProt", "db_id": "Q3BVU6" }, { "db_name": "UniProt", "db_id": "Q3J953" }, { "db_name": "UniProt", "db_id": "Q3SKU2" }, { "db_name": "UniProt", "db_id": "Q3Z310" }, { "db_name": "UniProt", "db_id": "Q4QLU8" }, { "db_name": "UniProt", "db_id": "Q4USG7" }, { "db_name": "UniProt", "db_id": "Q57QE6" }, { "db_name": "UniProt", "db_id": "Q5FA94" }, { "db_name": "UniProt", "db_id": "Q5H1Q0" }, { "db_name": "UniProt", "db_id": "Q5P081" }, { "db_name": "UniProt", "db_id": "Q5PGT0" }, { "db_name": "UniProt", "db_id": "Q5QUZ5" }, { "db_name": "UniProt", "db_id": "Q606N2" }, { "db_name": "UniProt", "db_id": "Q65VK7" }, { "db_name": "UniProt", "db_id": "Q669N5" }, { "db_name": "UniProt", "db_id": "Q6D674" }, { "db_name": "UniProt", "db_id": "Q6LJ30" }, { "db_name": "UniProt", "db_id": "Q7N397" }, { "db_name": "UniProt", "db_id": "Q7NWB7" }, { "db_name": "UniProt", "db_id": "Q7UCW4" }, { "db_name": "UniProt", "db_id": "Q7VNI8" }, { "db_name": "UniProt", "db_id": "Q7VWV8" }, { "db_name": "UniProt", "db_id": "Q7W9J5" }, { "db_name": "UniProt", "db_id": "Q7WH65" }, { "db_name": "UniProt", "db_id": "Q82SJ8" }, { "db_name": "UniProt", "db_id": "Q87BR5" }, { "db_name": "UniProt", "db_id": "Q89ZI2" }, { "db_name": "UniProt", "db_id": "Q8EEW2" }, { "db_name": "UniProt", "db_id": "Q8FIN2" }, { "db_name": "UniProt", "db_id": "Q8PB42" }, { "db_name": "UniProt", "db_id": "Q8PMU1" }, { "db_name": "UniProt", "db_id": "Q8VIJ5" }, { "db_name": "UniProt", "db_id": "Q8XL08" }, { "db_name": "UniProt", "db_id": "Q8Z7I6" }, { "db_name": "UniProt", "db_id": "Q8ZFS3" }, { "db_name": "UniProt", "db_id": "Q8ZQ06" }, { "db_name": "UniProt", "db_id": "Q9CPH0" }, { "db_name": "UniProt", "db_id": "Q9EQQ9" }, { "db_name": "UniProt", "db_id": "Q9HZK0" }, { "db_name": "UniProt", "db_id": "Q9JVT3" }, { "db_name": "UniProt", "db_id": "Q9K0Q4" }, { "db_name": "UniProt", "db_id": "Q9KU37" }, { "db_name": "UniProt", "db_id": "Q9PAZ0" } ] }, { "id": "DS.d210.s0.e1", "type": "compound", "text": [ "N-acetylglucosamine" ], "offsets": [ [ 104, 123 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "24139" } ] }, { "id": "DS.d210.s0.e2", "type": "compound", "text": [ "N-acetylgalactosamine" ], "offsets": [ [ 128, 149 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "899" }, { "db_name": "PubChem", "db_id": "35717" }, { "db_name": "PubChem", "db_id": "84265" }, { "db_name": "PubChem", "db_id": "439174" } ] } ]
[]
[]
[ { "id": "DS.d210.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d210.s0.e2", "arg2_id": "DS.d210.s0.e0", "normalized": [] }, { "id": "DS.d210.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d210.s0.e1", "arg2_id": "DS.d210.s0.e0", "normalized": [] } ]
DS.d211
18473182
[ { "id": "DS.d211.s0", "type": "", "text": [ "Overexpression of CYP2E1 induces HepG2 cells death by the AMP kinase activator 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR)." ], "offsets": [ [ 0, 143 ] ] } ]
[ { "id": "DS.d211.s0.e0", "type": "protein", "text": [ "CYP2E1" ], "offsets": [ [ 18, 24 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18963" }, { "db_name": "UniProt", "db_id": "P05181" }, { "db_name": "UniProt", "db_id": "P08682" }, { "db_name": "UniProt", "db_id": "P33266" }, { "db_name": "UniProt", "db_id": "P51581" }, { "db_name": "UniProt", "db_id": "P79383" }, { "db_name": "UniProt", "db_id": "Q6GUQ4" } ] }, { "id": "DS.d211.s0.e1", "type": "compound", "text": [ "5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside" ], "offsets": [ [ 79, 134 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "16078949" } ] } ]
[]
[]
[ { "id": "DS.d211.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d211.s0.e1", "arg2_id": "DS.d211.s0.e0", "normalized": [] } ]
DS.d212
18474445
[ { "id": "DS.d212.s0", "type": "", "text": [ "Distribution of the androgen receptor in the diencephalon and the pituitary gland in goats: Co-localisation with corticotrophin releasing hormone, arginine vasopressin and corticotrophs." ], "offsets": [ [ 0, 186 ] ] } ]
[ { "id": "DS.d212.s0.e0", "type": "protein", "text": [ "androgen receptor" ], "offsets": [ [ 20, 37 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O97775" }, { "db_name": "UniProt", "db_id": "O97776" }, { "db_name": "UniProt", "db_id": "O97952" }, { "db_name": "UniProt", "db_id": "O97960" }, { "db_name": "UniProt", "db_id": "P10275" }, { "db_name": "UniProt", "db_id": "P15207" }, { "db_name": "UniProt", "db_id": "P19091" }, { "db_name": "UniProt", "db_id": "P49699" }, { "db_name": "UniProt", "db_id": "Q6QT55" }, { "db_name": "UniProt", "db_id": "Q7T1K4" }, { "db_name": "UniProt", "db_id": "Q8MIK0" }, { "db_name": "UniProt", "db_id": "Q9GKL7" }, { "db_name": "UniProt", "db_id": "Q9TT90" } ] }, { "id": "DS.d212.s0.e1", "type": "compound", "text": [ "arginine vasopressin" ], "offsets": [ [ 147, 167 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "8230" }, { "db_name": "PubChem", "db_id": "644077" }, { "db_name": "PubChem", "db_id": "44285245" } ] } ]
[]
[]
[]
DS.d213
18475288
[ { "id": "DS.d213.s0", "type": "", "text": [ "Bicalutamide induced apoptosis in androgen-dependent PWR-1E cells via a caspase-dependent and calpain-independent mechanism." ], "offsets": [ [ 0, 124 ] ] }, { "id": "DS.d213.s1", "type": "", "text": [ "In androgen-independent PC-3 cells, bicalutamide also induced apoptosis by mechanisms that were partially inhibited by pan-caspase inhibition but were partially calpain dependent." ], "offsets": [ [ 125, 304 ] ] } ]
[ { "id": "DS.d213.s0.e0", "type": "compound", "text": [ "Bicalutamide" ], "offsets": [ [ 0, 12 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2375" } ] }, { "id": "DS.d213.s0.e1", "type": "protein", "text": [ "calpain" ], "offsets": [ [ 94, 101 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27730" } ] }, { "id": "DS.d213.s1.e0", "type": "compound", "text": [ "bicalutamide" ], "offsets": [ [ 161, 173 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2375" } ] }, { "id": "DS.d213.s1.e1", "type": "protein", "text": [ "calpain" ], "offsets": [ [ 286, 293 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27730" } ] } ]
[]
[]
[ { "id": "DS.d213.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d213.s0.e0", "arg2_id": "DS.d213.s0.e1", "normalized": [] }, { "id": "DS.d213.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d213.s1.e0", "arg2_id": "DS.d213.s1.e1", "normalized": [] } ]
DS.d214
18477686
[ { "id": "DS.d214.s0", "type": "", "text": [ "A differential regulation of the two GABA synthesizing enzymes (GAD65 and GAD67) parallels GABAergic neuron differentiation." ], "offsets": [ [ 0, 124 ] ] } ]
[ { "id": "DS.d214.s0.e0", "type": "compound", "text": [ "GABA" ], "offsets": [ [ 37, 41 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "119" } ] }, { "id": "DS.d214.s0.e1", "type": "protein", "text": [ "GAD65" ], "offsets": [ [ 64, 69 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P48321" }, { "db_name": "UniProt", "db_id": "Q05329" }, { "db_name": "UniProt", "db_id": "Q4PRC2" } ] }, { "id": "DS.d214.s0.e2", "type": "protein", "text": [ "GAD67" ], "offsets": [ [ 74, 79 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P14748" }, { "db_name": "UniProt", "db_id": "P48319" }, { "db_name": "UniProt", "db_id": "Q5IS68" }, { "db_name": "UniProt", "db_id": "Q99259" } ] } ]
[]
[]
[ { "id": "DS.d214.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d214.s0.e0", "arg2_id": "DS.d214.s0.e2", "normalized": [] }, { "id": "DS.d214.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d214.s0.e0", "arg2_id": "DS.d214.s0.e1", "normalized": [] } ]
DS.d215
18479249
[ { "id": "DS.d215.s0", "type": "", "text": [ "The results showed that portal pressure and IHR, hepatic levels of PIIINP, hepatic collagen deposition, mRNA expression of PIIIP-alpha1 and TGF-beta1, protein expression of iNOS and TXS, and production of TXA2 in liver perfusates were significantly decreased in UDCA-treated BDL rats." ], "offsets": [ [ 0, 284 ] ] }, { "id": "DS.d215.s1", "type": "", "text": [ "The increased levels of hepatic GSH and SOD activity and decreased levels of TBARS and nitrite were also observed in UDCA-treated BDL rats." ], "offsets": [ [ 285, 424 ] ] } ]
[ { "id": "DS.d215.s0.e0", "type": "protein", "text": [ "alpha1" ], "offsets": [ [ 129, 135 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q08398" } ] }, { "id": "DS.d215.s0.e1", "type": "protein", "text": [ "TGF-beta1" ], "offsets": [ [ 140, 149 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19011" }, { "db_name": "UniProt", "db_id": "O93449" }, { "db_name": "UniProt", "db_id": "P01137" }, { "db_name": "UniProt", "db_id": "P04202" }, { "db_name": "UniProt", "db_id": "P07200" }, { "db_name": "UniProt", "db_id": "P09531" }, { "db_name": "UniProt", "db_id": "P09533" }, { "db_name": "UniProt", "db_id": "P16176" }, { "db_name": "UniProt", "db_id": "P17246" }, { "db_name": "UniProt", "db_id": "P18341" }, { "db_name": "UniProt", "db_id": "P50414" }, { "db_name": "UniProt", "db_id": "P54831" }, { "db_name": "UniProt", "db_id": "Q38HS2" }, { "db_name": "UniProt", "db_id": "Q9PTQ2" }, { "db_name": "UniProt", "db_id": "Q9Z1Y6" } ] }, { "id": "DS.d215.s0.e2", "type": "protein", "text": [ "iNOS" ], "offsets": [ [ 173, 177 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19114" }, { "db_name": "UniProt", "db_id": "O46660" }, { "db_name": "UniProt", "db_id": "O54705" }, { "db_name": "UniProt", "db_id": "O62699" }, { "db_name": "UniProt", "db_id": "P29477" }, { "db_name": "UniProt", "db_id": "P35228" }, { "db_name": "UniProt", "db_id": "P79290" }, { "db_name": "UniProt", "db_id": "Q06518" }, { "db_name": "UniProt", "db_id": "Q27995" }, { "db_name": "UniProt", "db_id": "Q28314" }, { "db_name": "UniProt", "db_id": "Q90703" }, { "db_name": "UniProt", "db_id": "Q92037" }, { "db_name": "UniProt", "db_id": "Q92091" } ] }, { "id": "DS.d215.s0.e3", "type": "protein", "text": [ "TXS" ], "offsets": [ [ 182, 185 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P24557" }, { "db_name": "UniProt", "db_id": "P36423" }, { "db_name": "UniProt", "db_id": "P47787" }, { "db_name": "UniProt", "db_id": "P49430" }, { "db_name": "UniProt", "db_id": "Q2KIG5" } ] }, { "id": "DS.d215.s0.e4", "type": "compound", "text": [ "TXA2" ], "offsets": [ [ 205, 209 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280497" } ] }, { "id": "DS.d215.s1.e0", "type": "compound", "text": [ "GSH" ], "offsets": [ [ 317, 320 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d215.s1.e1", "type": "protein", "text": [ "SOD" ], "offsets": [ [ 325, 328 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O12933" }, { "db_name": "UniProt", "db_id": "O22668" }, { "db_name": "UniProt", "db_id": "O75007" }, { "db_name": "UniProt", "db_id": "P24705" }, { "db_name": "UniProt", "db_id": "P51547" }, { "db_name": "UniProt", "db_id": "P93258" }, { "db_name": "UniProt", "db_id": "Q01137" }, { "db_name": "UniProt", "db_id": "Q27666" }, { "db_name": "UniProt", "db_id": "Q9SM64" } ] } ]
[]
[]
[]
DS.d216
18479251
[ { "id": "DS.d216.s0", "type": "", "text": [ "The production of rhG-CSF was induced by switching from growth on glycerol to growth on methanol." ], "offsets": [ [ 0, 97 ] ] }, { "id": "DS.d216.s1", "type": "", "text": [ "In the induction phase, the methanol feed rate had a significant effect on the specific expression rate of rhG-CSF." ], "offsets": [ [ 98, 213 ] ] }, { "id": "DS.d216.s2", "type": "", "text": [ "Under this condition, a maximum concentration of 300 mg/l of rhG-CSF and the expression yield of 0.6 mg of rhG-CSF/g of methanol were attained." ], "offsets": [ [ 214, 357 ] ] }, { "id": "DS.d216.s3", "type": "", "text": [ "Among seven additives tested, Tween 20, Tween 80 and betaine exhibited the best results in respect of preventing the formation of rhG-CSF protein aggregates." ], "offsets": [ [ 358, 515 ] ] } ]
[ { "id": "DS.d216.s0.e0", "type": "protein", "text": [ "CSF" ], "offsets": [ [ 22, 25 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62757" }, { "db_name": "UniProt", "db_id": "P01587" }, { "db_name": "UniProt", "db_id": "P04141" }, { "db_name": "UniProt", "db_id": "P11052" }, { "db_name": "UniProt", "db_id": "P28773" }, { "db_name": "UniProt", "db_id": "P48749" }, { "db_name": "UniProt", "db_id": "P48750" }, { "db_name": "UniProt", "db_id": "P51748" }, { "db_name": "UniProt", "db_id": "Q0MUT8" }, { "db_name": "UniProt", "db_id": "Q29118" }, { "db_name": "UniProt", "db_id": "Q60481" } ] }, { "id": "DS.d216.s0.e1", "type": "compound", "text": [ "glycerol" ], "offsets": [ [ 66, 74 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "753" } ] }, { "id": "DS.d216.s0.e2", "type": "compound", "text": [ "methanol" ], "offsets": [ [ 88, 96 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "887" }, { "db_name": "PubChem", "db_id": "19314" } ] }, { "id": "DS.d216.s1.e0", "type": "compound", "text": [ "methanol" ], "offsets": [ [ 126, 134 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "887" }, { "db_name": "PubChem", "db_id": "19314" } ] }, { "id": "DS.d216.s1.e1", "type": "protein", "text": [ "CSF" ], "offsets": [ [ 209, 212 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62757" }, { "db_name": "UniProt", "db_id": "P01587" }, { "db_name": "UniProt", "db_id": "P04141" }, { "db_name": "UniProt", "db_id": "P11052" }, { "db_name": "UniProt", "db_id": "P28773" }, { "db_name": "UniProt", "db_id": "P48749" }, { "db_name": "UniProt", "db_id": "P48750" }, { "db_name": "UniProt", "db_id": "P51748" }, { "db_name": "UniProt", "db_id": "Q0MUT8" }, { "db_name": "UniProt", "db_id": "Q29118" }, { "db_name": "UniProt", "db_id": "Q60481" } ] }, { "id": "DS.d216.s2.e0", "type": "protein", "text": [ "CSF" ], "offsets": [ [ 279, 282 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62757" }, { "db_name": "UniProt", "db_id": "P01587" }, { "db_name": "UniProt", "db_id": "P04141" }, { "db_name": "UniProt", "db_id": "P11052" }, { "db_name": "UniProt", "db_id": "P28773" }, { "db_name": "UniProt", "db_id": "P48749" }, { "db_name": "UniProt", "db_id": "P48750" }, { "db_name": "UniProt", "db_id": "P51748" }, { "db_name": "UniProt", "db_id": "Q0MUT8" }, { "db_name": "UniProt", "db_id": "Q29118" }, { "db_name": "UniProt", "db_id": "Q60481" } ] }, { "id": "DS.d216.s2.e1", "type": "protein", "text": [ "CSF" ], "offsets": [ [ 325, 328 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62757" }, { "db_name": "UniProt", "db_id": "P01587" }, { "db_name": "UniProt", "db_id": "P04141" }, { "db_name": "UniProt", "db_id": "P11052" }, { "db_name": "UniProt", "db_id": "P28773" }, { "db_name": "UniProt", "db_id": "P48749" }, { "db_name": "UniProt", "db_id": "P48750" }, { "db_name": "UniProt", "db_id": "P51748" }, { "db_name": "UniProt", "db_id": "Q0MUT8" }, { "db_name": "UniProt", "db_id": "Q29118" }, { "db_name": "UniProt", "db_id": "Q60481" } ] }, { "id": "DS.d216.s2.e2", "type": "compound", "text": [ "methanol" ], "offsets": [ [ 334, 342 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "887" }, { "db_name": "PubChem", "db_id": "19314" } ] }, { "id": "DS.d216.s3.e0", "type": "compound", "text": [ "Tween 20" ], "offsets": [ [ 388, 396 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "443314" } ] }, { "id": "DS.d216.s3.e1", "type": "compound", "text": [ "betaine" ], "offsets": [ [ 411, 418 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "248" } ] }, { "id": "DS.d216.s3.e2", "type": "protein", "text": [ "CSF" ], "offsets": [ [ 492, 495 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62757" }, { "db_name": "UniProt", "db_id": "P01587" }, { "db_name": "UniProt", "db_id": "P04141" }, { "db_name": "UniProt", "db_id": "P11052" }, { "db_name": "UniProt", "db_id": "P28773" }, { "db_name": "UniProt", "db_id": "P48749" }, { "db_name": "UniProt", "db_id": "P48750" }, { "db_name": "UniProt", "db_id": "P51748" }, { "db_name": "UniProt", "db_id": "Q0MUT8" }, { "db_name": "UniProt", "db_id": "Q29118" }, { "db_name": "UniProt", "db_id": "Q60481" } ] } ]
[]
[]
[ { "id": "DS.d216.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d216.s0.e2", "arg2_id": "DS.d216.s0.e0", "normalized": [] }, { "id": "DS.d216.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d216.s1.e0", "arg2_id": "DS.d216.s1.e1", "normalized": [] }, { "id": "DS.d216.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d216.s2.e2", "arg2_id": "DS.d216.s2.e0", "normalized": [] }, { "id": "DS.d216.s3.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d216.s3.e0", "arg2_id": "DS.d216.s3.e2", "normalized": [] }, { "id": "DS.d216.s3.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d216.s3.e1", "arg2_id": "DS.d216.s3.e2", "normalized": [] } ]
DS.d217
18479686
[ { "id": "DS.d217.s0", "type": "", "text": [ "Ezetimibe potently reduces vascular inflammation and arteriosclerosis in eNOS-deficient ApoE ko mice." ], "offsets": [ [ 0, 101 ] ] }, { "id": "DS.d217.s1", "type": "", "text": [ "Hypercholesterolemia is associated with decreased vascular nitric oxide bioavailability and deletion of endothelial nitric oxide synthase (eNOS) markedly accelerates atherosclerosis development in apolipoprotein E knockout (apoE ko) mice." ], "offsets": [ [ 102, 340 ] ] } ]
[ { "id": "DS.d217.s0.e0", "type": "compound", "text": [ "Ezetimibe" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "150311" } ] }, { "id": "DS.d217.s0.e1", "type": "protein", "text": [ "eNOS" ], "offsets": [ [ 73, 77 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P29473" }, { "db_name": "UniProt", "db_id": "P29474" }, { "db_name": "UniProt", "db_id": "P70313" }, { "db_name": "UniProt", "db_id": "P79209" }, { "db_name": "UniProt", "db_id": "P97270" }, { "db_name": "UniProt", "db_id": "Q28969" }, { "db_name": "UniProt", "db_id": "Q62600" } ] }, { "id": "DS.d217.s1.e0", "type": "compound", "text": [ "nitric oxide" ], "offsets": [ [ 161, 173 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "145068" } ] }, { "id": "DS.d217.s1.e1", "type": "protein", "text": [ "nitric oxide synthase" ], "offsets": [ [ 218, 239 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O61309" }, { "db_name": "UniProt", "db_id": "O61608" }, { "db_name": "UniProt", "db_id": "Q27571" }, { "db_name": "UniProt", "db_id": "Q9I9M2" } ] }, { "id": "DS.d217.s1.e2", "type": "protein", "text": [ "eNOS" ], "offsets": [ [ 241, 245 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P29473" }, { "db_name": "UniProt", "db_id": "P29474" }, { "db_name": "UniProt", "db_id": "P70313" }, { "db_name": "UniProt", "db_id": "P79209" }, { "db_name": "UniProt", "db_id": "P97270" }, { "db_name": "UniProt", "db_id": "Q28969" }, { "db_name": "UniProt", "db_id": "Q62600" } ] } ]
[]
[]
[ { "id": "DS.d217.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d217.s0.e0", "arg2_id": "DS.d217.s0.e1", "normalized": [] } ]
DS.d218
18479896
[ { "id": "DS.d218.s0", "type": "", "text": [ "Docosahexaenoic acid induces apoptosis in colorectal carcinoma cells by modulating the PI3 kinase and p38 MAPK pathways." ], "offsets": [ [ 0, 120 ] ] }, { "id": "DS.d218.s1", "type": "", "text": [ "The protein inhibitors wortmannin (phosphoinositide 3 kinase inhibitor), PD 98059 (MEK inhibitor) and SB 203580 (p38 inhibitor) as well as silencing RNA (small interfering RNA (siRNA)) of the p38 MAPK protein, were used to investigate cross-talk between signalling pathways." ], "offsets": [ [ 121, 395 ] ] } ]
[ { "id": "DS.d218.s0.e0", "type": "compound", "text": [ "Docosahexaenoic acid" ], "offsets": [ [ 0, 20 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "445580" } ] }, { "id": "DS.d218.s0.e1", "type": "protein", "text": [ "PI3 kinase" ], "offsets": [ [ 87, 97 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P42347" }, { "db_name": "UniProt", "db_id": "P42348" }, { "db_name": "UniProt", "db_id": "P54673" }, { "db_name": "UniProt", "db_id": "P54674" }, { "db_name": "UniProt", "db_id": "P54675" }, { "db_name": "UniProt", "db_id": "P54676" } ] }, { "id": "DS.d218.s0.e2", "type": "protein", "text": [ "p38 MAPK" ], "offsets": [ [ 102, 110 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62618" } ] }, { "id": "DS.d218.s1.e0", "type": "compound", "text": [ "wortmannin" ], "offsets": [ [ 144, 154 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "312145" } ] }, { "id": "DS.d218.s1.e1", "type": "compound", "text": [ "phosphoinositide" ], "offsets": [ [ 156, 172 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "16738692" } ] }, { "id": "DS.d218.s1.e2", "type": "compound", "text": [ "PD 98059" ], "offsets": [ [ 194, 202 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4713" } ] }, { "id": "DS.d218.s1.e3", "type": "compound", "text": [ "SB 203580" ], "offsets": [ [ 223, 232 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "176155" } ] }, { "id": "DS.d218.s1.e4", "type": "protein", "text": [ "p38 MAPK" ], "offsets": [ [ 313, 321 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62618" } ] } ]
[]
[]
[ { "id": "DS.d218.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d218.s0.e0", "arg2_id": "DS.d218.s0.e1", "normalized": [] }, { "id": "DS.d218.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d218.s0.e0", "arg2_id": "DS.d218.s0.e2", "normalized": [] } ]
DS.d219
18479897
[ { "id": "DS.d219.s0", "type": "", "text": [ "Feeding long-chain n-3 polyunsaturated fatty acids during gestation increases intestinal glucose absorption potentially via the acute activation of AMPK." ], "offsets": [ [ 0, 153 ] ] }, { "id": "DS.d219.s1", "type": "", "text": [ "Furthermore, adding docosahexaenoic acid (DHA) or an AMP-activated protein kinase (AMPK.05) in intestinal preparations obtained from the offspring fed the control diet, devoid of the PFO product and containing minimal concentrations of n-3 PUFA." ], "offsets": [ [ 154, 399 ] ] } ]
[ { "id": "DS.d219.s0.e0", "type": "compound", "text": [ "polyunsaturated fatty acids" ], "offsets": [ [ 23, 50 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "56842239" } ] }, { "id": "DS.d219.s0.e1", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 89, 96 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d219.s0.e2", "type": "protein", "text": [ "AMPK" ], "offsets": [ [ 148, 152 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P54646" }, { "db_name": "UniProt", "db_id": "Q09136" }, { "db_name": "UniProt", "db_id": "Q9Y478" } ] }, { "id": "DS.d219.s1.e0", "type": "compound", "text": [ "docosahexaenoic acid" ], "offsets": [ [ 174, 194 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "445580" } ] }, { "id": "DS.d219.s1.e1", "type": "protein", "text": [ "AMP" ], "offsets": [ [ 207, 210 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O24006" } ] }, { "id": "DS.d219.s1.e2", "type": "protein", "text": [ "protein kinase" ], "offsets": [ [ 221, 235 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P00513" }, { "db_name": "UniProt", "db_id": "P25848" } ] }, { "id": "DS.d219.s1.e3", "type": "protein", "text": [ "AMPK" ], "offsets": [ [ 237, 241 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P54646" }, { "db_name": "UniProt", "db_id": "Q09136" }, { "db_name": "UniProt", "db_id": "Q9Y478" } ] } ]
[]
[]
[ { "id": "DS.d219.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d219.s0.e0", "arg2_id": "DS.d219.s0.e2", "normalized": [] } ]
DS.d220
18479950
[ { "id": "DS.d220.s0", "type": "", "text": [ "Prior to vitamin E supplementation, exercise induced a significant decrease in PON1 activity, EMF, vitamin E concentration and a significant increase in MDA concentration at t+1d." ], "offsets": [ [ 0, 179 ] ] }, { "id": "DS.d220.s1", "type": "", "text": [ "After a 10 week vitamin E supplementation period, these exercise-induced changes in PON1 activity, EMF and MDA concentration were still significant in the control group, but not in the supplemented group." ], "offsets": [ [ 180, 384 ] ] } ]
[ { "id": "DS.d220.s0.e0", "type": "compound", "text": [ "vitamin E" ], "offsets": [ [ 9, 18 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2116" }, { "db_name": "PubChem", "db_id": "14985" }, { "db_name": "PubChem", "db_id": "1548900" }, { "db_name": "PubChem", "db_id": "1742129" } ] }, { "id": "DS.d220.s0.e1", "type": "protein", "text": [ "PON1" ], "offsets": [ [ 79, 83 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27169" }, { "db_name": "UniProt", "db_id": "P27170" } ] }, { "id": "DS.d220.s0.e2", "type": "compound", "text": [ "EMF" ], "offsets": [ [ 94, 97 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23644574" } ] }, { "id": "DS.d220.s0.e3", "type": "compound", "text": [ "vitamin E" ], "offsets": [ [ 99, 108 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2116" }, { "db_name": "PubChem", "db_id": "14985" }, { "db_name": "PubChem", "db_id": "1548900" }, { "db_name": "PubChem", "db_id": "1742129" } ] }, { "id": "DS.d220.s1.e0", "type": "compound", "text": [ "vitamin E" ], "offsets": [ [ 196, 205 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2116" }, { "db_name": "PubChem", "db_id": "14985" }, { "db_name": "PubChem", "db_id": "1548900" }, { "db_name": "PubChem", "db_id": "1742129" } ] }, { "id": "DS.d220.s1.e1", "type": "protein", "text": [ "PON1" ], "offsets": [ [ 264, 268 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27169" }, { "db_name": "UniProt", "db_id": "P27170" } ] }, { "id": "DS.d220.s1.e2", "type": "compound", "text": [ "EMF" ], "offsets": [ [ 279, 282 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23644574" } ] } ]
[]
[]
[ { "id": "DS.d220.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d220.s1.e0", "arg2_id": "DS.d220.s1.e1", "normalized": [] } ]
DS.d221
18481266
[ { "id": "DS.d221.s0", "type": "", "text": [ "In adulthood, testosterone secreted by the testes is converted into estrogens by the preoptic aromatase." ], "offsets": [ [ 0, 104 ] ] } ]
[ { "id": "DS.d221.s0.e0", "type": "compound", "text": [ "testosterone" ], "offsets": [ [ 14, 26 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6013" } ] }, { "id": "DS.d221.s0.e1", "type": "protein", "text": [ "aromatase" ], "offsets": [ [ 94, 103 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42145" }, { "db_name": "UniProt", "db_id": "O46512" }, { "db_name": "UniProt", "db_id": "P11511" }, { "db_name": "UniProt", "db_id": "P19098" }, { "db_name": "UniProt", "db_id": "P22443" }, { "db_name": "UniProt", "db_id": "P28649" }, { "db_name": "UniProt", "db_id": "P46194" }, { "db_name": "UniProt", "db_id": "P70091" }, { "db_name": "UniProt", "db_id": "P79304" }, { "db_name": "UniProt", "db_id": "P79430" }, { "db_name": "UniProt", "db_id": "P79699" }, { "db_name": "UniProt", "db_id": "Q29605" }, { "db_name": "UniProt", "db_id": "Q29624" }, { "db_name": "UniProt", "db_id": "Q5QQX7" }, { "db_name": "UniProt", "db_id": "Q69FB6" }, { "db_name": "UniProt", "db_id": "Q6QHT9" }, { "db_name": "UniProt", "db_id": "Q6YI21" }, { "db_name": "UniProt", "db_id": "Q92087" }, { "db_name": "UniProt", "db_id": "Q92111" }, { "db_name": "UniProt", "db_id": "Q92112" }, { "db_name": "UniProt", "db_id": "Q95M61" }, { "db_name": "UniProt", "db_id": "Q9XS28" } ] } ]
[]
[]
[ { "id": "DS.d221.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d221.s0.e0", "arg2_id": "DS.d221.s0.e1", "normalized": [] } ]
DS.d222
18481276
[ { "id": "DS.d222.s0", "type": "", "text": [ "The model was used to investigate how on-treatment CRP related to baseline CRP and estimated treatment effects with rosuvastatin." ], "offsets": [ [ 0, 129 ] ] } ]
[ { "id": "DS.d222.s0.e0", "type": "protein", "text": [ "CRP" ], "offsets": [ [ 51, 54 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19062" }, { "db_name": "UniProt", "db_id": "P02741" }, { "db_name": "UniProt", "db_id": "P02742" }, { "db_name": "UniProt", "db_id": "P08462" }, { "db_name": "UniProt", "db_id": "P18151" }, { "db_name": "UniProt", "db_id": "P21291" }, { "db_name": "UniProt", "db_id": "P41964" }, { "db_name": "UniProt", "db_id": "P47875" }, { "db_name": "UniProt", "db_id": "P49254" }, { "db_name": "UniProt", "db_id": "P49262" }, { "db_name": "UniProt", "db_id": "P52753" }, { "db_name": "UniProt", "db_id": "P67966" }, { "db_name": "UniProt", "db_id": "P67967" }, { "db_name": "UniProt", "db_id": "P97315" }, { "db_name": "UniProt", "db_id": "Q07203" } ] }, { "id": "DS.d222.s0.e1", "type": "protein", "text": [ "CRP" ], "offsets": [ [ 75, 78 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19062" }, { "db_name": "UniProt", "db_id": "P02741" }, { "db_name": "UniProt", "db_id": "P02742" }, { "db_name": "UniProt", "db_id": "P08462" }, { "db_name": "UniProt", "db_id": "P18151" }, { "db_name": "UniProt", "db_id": "P21291" }, { "db_name": "UniProt", "db_id": "P41964" }, { "db_name": "UniProt", "db_id": "P47875" }, { "db_name": "UniProt", "db_id": "P49254" }, { "db_name": "UniProt", "db_id": "P49262" }, { "db_name": "UniProt", "db_id": "P52753" }, { "db_name": "UniProt", "db_id": "P67966" }, { "db_name": "UniProt", "db_id": "P67967" }, { "db_name": "UniProt", "db_id": "P97315" }, { "db_name": "UniProt", "db_id": "Q07203" } ] }, { "id": "DS.d222.s0.e2", "type": "compound", "text": [ "rosuvastatin" ], "offsets": [ [ 116, 128 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "446157" } ] } ]
[]
[]
[ { "id": "DS.d222.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d222.s0.e2", "arg2_id": "DS.d222.s0.e0", "normalized": [] } ]
DS.d223
18481313
[ { "id": "DS.d223.s0", "type": "", "text": [ "Hepatocyte growth factor, keratinocyte growth factor or insulin prevented the effect of ethanol on cell permeability, but not on PGE (2) release." ], "offsets": [ [ 0, 145 ] ] }, { "id": "DS.d223.s1", "type": "", "text": [ "Cyclooxygenase-2 stimulated PGE (2) release mediated the reversible effect of ethanol on tight junctions and, meanwhile, contributed to cell survival." ], "offsets": [ [ 146, 296 ] ] } ]
[ { "id": "DS.d223.s0.e0", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 56, 63 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d223.s0.e1", "type": "compound", "text": [ "ethanol" ], "offsets": [ [ 88, 95 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "702" } ] }, { "id": "DS.d223.s0.e2", "type": "protein", "text": [ "PGE" ], "offsets": [ [ 129, 132 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q29458" } ] }, { "id": "DS.d223.s1.e0", "type": "protein", "text": [ "Cyclooxygenase-2" ], "offsets": [ [ 146, 162 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02768" }, { "db_name": "UniProt", "db_id": "O19183" }, { "db_name": "UniProt", "db_id": "O62698" }, { "db_name": "UniProt", "db_id": "O62725" }, { "db_name": "UniProt", "db_id": "P27607" }, { "db_name": "UniProt", "db_id": "P35354" }, { "db_name": "UniProt", "db_id": "P35355" }, { "db_name": "UniProt", "db_id": "P70682" }, { "db_name": "UniProt", "db_id": "P79208" }, { "db_name": "UniProt", "db_id": "Q05769" } ] }, { "id": "DS.d223.s1.e1", "type": "protein", "text": [ "PGE" ], "offsets": [ [ 174, 177 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q29458" } ] }, { "id": "DS.d223.s1.e2", "type": "compound", "text": [ "ethanol" ], "offsets": [ [ 224, 231 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "702" } ] } ]
[]
[]
[ { "id": "DS.d223.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d223.s0.e1", "arg2_id": "DS.d223.s0.e0", "normalized": [] }, { "id": "DS.d223.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d223.s1.e2", "arg2_id": "DS.d223.s1.e0", "normalized": [] }, { "id": "DS.d223.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d223.s1.e2", "arg2_id": "DS.d223.s1.e1", "normalized": [] } ]
DS.d224
18482727
[ { "id": "DS.d224.s0", "type": "", "text": [ "Interestingly, atorvastatin inhibited the expression of ICAM and MCP-1, followed by the suppression of macrophage recruitment into the aortic wall at 1 week after operation." ], "offsets": [ [ 0, 173 ] ] }, { "id": "DS.d224.s1", "type": "", "text": [ "In addition, synthesis of collagen and elastin in the vascular wall were significantly increased by atorvastatin." ], "offsets": [ [ 174, 287 ] ] } ]
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[]
[]
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DS.d225
18484100
[ { "id": "DS.d225.s0", "type": "", "text": [ "Organic cations (OCs) are primarily excreted via vectorial transport by various renal organic cation transporters (OCTs)." ], "offsets": [ [ 0, 121 ] ] }, { "id": "DS.d225.s1", "type": "", "text": [ "In a rat ARF model, induction of ARF by uranyl nitrate (UN) treatment significantly decreased the levels of Oct2 (slc22a2) mRNA and protein in the kidney medulla." ], "offsets": [ [ 122, 284 ] ] } ]
[ { "id": "DS.d225.s0.e0", "type": "compound", "text": [ "OCs" ], "offsets": [ [ 17, 20 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "72886" } ] }, { "id": "DS.d225.s0.e1", "type": "protein", "text": [ "OCTs" ], "offsets": [ [ 115, 119 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O75051" } ] }, { "id": "DS.d225.s1.e0", "type": "compound", "text": [ "uranyl nitrate" ], "offsets": [ [ 162, 176 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "24933" } ] }, { "id": "DS.d225.s1.e1", "type": "protein", "text": [ "Oct2" ], "offsets": [ [ 230, 234 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q00196" } ] } ]
[]
[]
[ { "id": "DS.d225.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d225.s0.e0", "arg2_id": "DS.d225.s0.e1", "normalized": [] }, { "id": "DS.d225.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d225.s1.e0", "arg2_id": "DS.d225.s1.e1", "normalized": [] } ]
DS.d226
18484622
[ { "id": "DS.d226.s0", "type": "", "text": [ "In all final products, dimethylsulfoxide used to prepare the insulin/lipid mixture was below 20 ppm." ], "offsets": [ [ 0, 100 ] ] } ]
[ { "id": "DS.d226.s0.e0", "type": "compound", "text": [ "dimethylsulfoxide" ], "offsets": [ [ 23, 40 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "679" } ] }, { "id": "DS.d226.s0.e1", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 61, 68 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] } ]
[]
[]
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DS.d227
18485500
[ { "id": "DS.d227.s0", "type": "", "text": [ "Platelet reactivity and clopidogrel resistance are associated with the H2 haplotype of the P2Y12-ADP receptor gene." ], "offsets": [ [ 0, 115 ] ] } ]
[ { "id": "DS.d227.s0.e0", "type": "compound", "text": [ "clopidogrel" ], "offsets": [ [ 24, 35 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2806" }, { "db_name": "PubChem", "db_id": "60606" } ] }, { "id": "DS.d227.s0.e1", "type": "protein", "text": [ "P2Y12" ], "offsets": [ [ 91, 96 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q95KC3" }, { "db_name": "UniProt", "db_id": "Q9CPV9" }, { "db_name": "UniProt", "db_id": "Q9EPX4" }, { "db_name": "UniProt", "db_id": "Q9H244" } ] }, { "id": "DS.d227.s0.e2", "type": "protein", "text": [ "ADP" ], "offsets": [ [ 97, 100 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02783" } ] } ]
[]
[]
[ { "id": "DS.d227.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d227.s0.e0", "arg2_id": "DS.d227.s0.e2", "normalized": [] }, { "id": "DS.d227.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d227.s0.e0", "arg2_id": "DS.d227.s0.e1", "normalized": [] } ]
DS.d228
18486150
[ { "id": "DS.d228.s0", "type": "", "text": [ "Cyclosporin A up-regulates and activates protein kinase C-zeta in EBV-infected and EBV-transformed human B-cells." ], "offsets": [ [ 0, 113 ] ] }, { "id": "DS.d228.s1", "type": "", "text": [ "We have proposed that cyclosporin A (CsA), despite being a calcineurin inhibitor, will activate PKC in B cells, thus promoting Epstein-Barr virus (EBV)-induced transformation." ], "offsets": [ [ 114, 289 ] ] } ]
[ { "id": "DS.d228.s0.e0", "type": "compound", "text": [ "Cyclosporin A" ], "offsets": [ [ 0, 13 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2909" }, { "db_name": "PubChem", "db_id": "5280754" }, { "db_name": "PubChem", "db_id": "5284373" }, { "db_name": "PubChem", "db_id": "5458585" }, { "db_name": "PubChem", "db_id": "5497195" }, { "db_name": "PubChem", "db_id": "6435893" }, { "db_name": "PubChem", "db_id": "24883466" }, { "db_name": "PubChem", "db_id": "49867938" } ] }, { "id": "DS.d228.s0.e1", "type": "protein", "text": [ "protein kinase C" ], "offsets": [ [ 41, 57 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P13678" }, { "db_name": "UniProt", "db_id": "Q25378" } ] }, { "id": "DS.d228.s1.e0", "type": "compound", "text": [ "cyclosporin A" ], "offsets": [ [ 136, 149 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2909" }, { "db_name": "PubChem", "db_id": "5280754" }, { "db_name": "PubChem", "db_id": "5284373" }, { "db_name": "PubChem", "db_id": "5458585" }, { "db_name": "PubChem", "db_id": "5497195" }, { "db_name": "PubChem", "db_id": "6435893" }, { "db_name": "PubChem", "db_id": "24883466" }, { "db_name": "PubChem", "db_id": "49867938" } ] }, { "id": "DS.d228.s1.e1", "type": "protein", "text": [ "calcineurin inhibitor" ], "offsets": [ [ 173, 194 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O88480" }, { "db_name": "UniProt", "db_id": "Q9Y6J0" } ] }, { "id": "DS.d228.s1.e2", "type": "protein", "text": [ "PKC" ], "offsets": [ [ 210, 213 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05130" }, { "db_name": "UniProt", "db_id": "P13677" }, { "db_name": "UniProt", "db_id": "P13678" }, { "db_name": "UniProt", "db_id": "P34722" } ] } ]
[]
[]
[ { "id": "DS.d228.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d228.s0.e0", "arg2_id": "DS.d228.s0.e1", "normalized": [] }, { "id": "DS.d228.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d228.s1.e0", "arg2_id": "DS.d228.s1.e1", "normalized": [] }, { "id": "DS.d228.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d228.s1.e0", "arg2_id": "DS.d228.s1.e2", "normalized": [] } ]
DS.d229
18486994
[ { "id": "DS.d229.s0", "type": "", "text": [ "Our results showed 2a, 2d and 2g as the most active compounds that inhibited the HIV-1 reverse transcriptase catalytic activity with cytotoxicity lower than AZT and SI higher than DDC and DDI." ], "offsets": [ [ 0, 192 ] ] } ]
[ { "id": "DS.d229.s0.e0", "type": "protein", "text": [ "transcriptase" ], "offsets": [ [ 95, 108 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O55528" }, { "db_name": "UniProt", "db_id": "O89344" }, { "db_name": "UniProt", "db_id": "P03523" }, { "db_name": "UniProt", "db_id": "P06447" }, { "db_name": "UniProt", "db_id": "P06829" }, { "db_name": "UniProt", "db_id": "P11205" }, { "db_name": "UniProt", "db_id": "P11213" }, { "db_name": "UniProt", "db_id": "P12576" }, { "db_name": "UniProt", "db_id": "P12577" }, { "db_name": "UniProt", "db_id": "P13179" }, { "db_name": "UniProt", "db_id": "P13615" }, { "db_name": "UniProt", "db_id": "P16289" }, { "db_name": "UniProt", "db_id": "P16379" }, { "db_name": "UniProt", "db_id": "P20894" }, { "db_name": "UniProt", "db_id": "P24658" }, { "db_name": "UniProt", "db_id": "P26676" }, { "db_name": "UniProt", "db_id": "P28887" }, { "db_name": "UniProt", "db_id": "P30929" }, { "db_name": "UniProt", "db_id": "P31332" }, { "db_name": "UniProt", "db_id": "P31352" }, { "db_name": "UniProt", "db_id": "P35262" }, { "db_name": "UniProt", "db_id": "P35341" }, { "db_name": "UniProt", "db_id": "P35946" }, { "db_name": "UniProt", "db_id": "P35975" }, { "db_name": "UniProt", "db_id": "P41357" }, { "db_name": "UniProt", "db_id": "Q03396" }, { "db_name": "UniProt", "db_id": "Q05318" }, { "db_name": "UniProt", "db_id": "Q06996" }, { "db_name": "UniProt", "db_id": "Q5XX01" }, { "db_name": "UniProt", "db_id": "Q66802" }, { "db_name": "UniProt", "db_id": "Q6V1Q2" }, { "db_name": "UniProt", "db_id": "Q88434" }, { "db_name": "UniProt", "db_id": "Q8JPX5" }, { "db_name": "UniProt", "db_id": "Q91DD4" }, { "db_name": "UniProt", "db_id": "Q997F0" }, { "db_name": "UniProt", "db_id": "Q9DUD8" } ] }, { "id": "DS.d229.s0.e1", "type": "compound", "text": [ "AZT" ], "offsets": [ [ 157, 160 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "35370" } ] } ]
[]
[]
[ { "id": "DS.d229.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d229.s0.e1", "arg2_id": "DS.d229.s0.e0", "normalized": [] } ]
DS.d230
18487053
[ { "id": "DS.d230.s0", "type": "", "text": [ "Resveratrol (4,3',5'-trihydroxystilbene) is a naturally occurring antioxidant that inhibits cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and the transcription factor NF-kappaB." ], "offsets": [ [ 0, 182 ] ] } ]
[ { "id": "DS.d230.s0.e0", "type": "compound", "text": [ "Resveratrol" ], "offsets": [ [ 0, 11 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "445154" } ] }, { "id": "DS.d230.s0.e1", "type": "protein", "text": [ "cyclooxygenase-1" ], "offsets": [ [ 92, 108 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62664" }, { "db_name": "UniProt", "db_id": "O97554" }, { "db_name": "UniProt", "db_id": "P05979" }, { "db_name": "UniProt", "db_id": "P22437" }, { "db_name": "UniProt", "db_id": "P23219" }, { "db_name": "UniProt", "db_id": "Q63921" } ] }, { "id": "DS.d230.s0.e2", "type": "protein", "text": [ "COX-1" ], "offsets": [ [ 110, 115 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62664" }, { "db_name": "UniProt", "db_id": "O97554" }, { "db_name": "UniProt", "db_id": "P05979" }, { "db_name": "UniProt", "db_id": "P22437" }, { "db_name": "UniProt", "db_id": "P23219" }, { "db_name": "UniProt", "db_id": "Q63921" }, { "db_name": "UniProt", "db_id": "Q9T0N8" } ] }, { "id": "DS.d230.s0.e3", "type": "protein", "text": [ "cyclooxygenase-2" ], "offsets": [ [ 118, 134 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02768" }, { "db_name": "UniProt", "db_id": "O19183" }, { "db_name": "UniProt", "db_id": "O62698" }, { "db_name": "UniProt", "db_id": "O62725" }, { "db_name": "UniProt", "db_id": "P27607" }, { "db_name": "UniProt", "db_id": "P35354" }, { "db_name": "UniProt", "db_id": "P35355" }, { "db_name": "UniProt", "db_id": "P70682" }, { "db_name": "UniProt", "db_id": "P79208" }, { "db_name": "UniProt", "db_id": "Q05769" } ] }, { "id": "DS.d230.s0.e4", "type": "protein", "text": [ "COX-2" ], "offsets": [ [ 136, 141 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02768" }, { "db_name": "UniProt", "db_id": "O19183" }, { "db_name": "UniProt", "db_id": "O62698" }, { "db_name": "UniProt", "db_id": "O62725" }, { "db_name": "UniProt", "db_id": "P27607" }, { "db_name": "UniProt", "db_id": "P35354" }, { "db_name": "UniProt", "db_id": "P35355" }, { "db_name": "UniProt", "db_id": "P70682" }, { "db_name": "UniProt", "db_id": "P79208" }, { "db_name": "UniProt", "db_id": "Q05769" } ] } ]
[]
[]
[ { "id": "DS.d230.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d230.s0.e0", "arg2_id": "DS.d230.s0.e3", "normalized": [] }, { "id": "DS.d230.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d230.s0.e0", "arg2_id": "DS.d230.s0.e1", "normalized": [] }, { "id": "DS.d230.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d230.s0.e0", "arg2_id": "DS.d230.s0.e2", "normalized": [] }, { "id": "DS.d230.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d230.s0.e0", "arg2_id": "DS.d230.s0.e4", "normalized": [] } ]
DS.d231
18489490
[ { "id": "DS.d231.s0", "type": "", "text": [ "After NMDA stimulation of SV-FHAS and neoplastic astrocytes, real-time polymerase chain reaction showed an increase of the CPE, containing EGR-1 splice variant only in astrocytoma cells." ], "offsets": [ [ 0, 186 ] ] } ]
[ { "id": "DS.d231.s0.e0", "type": "compound", "text": [ "NMDA" ], "offsets": [ [ 6, 10 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "22880" } ] }, { "id": "DS.d231.s0.e1", "type": "protein", "text": [ "EGR-1" ], "offsets": [ [ 139, 144 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O73691" }, { "db_name": "UniProt", "db_id": "O73692" }, { "db_name": "UniProt", "db_id": "O73693" }, { "db_name": "UniProt", "db_id": "O73694" }, { "db_name": "UniProt", "db_id": "P08046" }, { "db_name": "UniProt", "db_id": "P08154" }, { "db_name": "UniProt", "db_id": "P18146" }, { "db_name": "UniProt", "db_id": "P26632" }, { "db_name": "UniProt", "db_id": "Q29W20" } ] } ]
[]
[]
[]
DS.d232
18489909
[ { "id": "DS.d232.s0", "type": "", "text": [ "Using both physiologically achievable (2 microM) and supraphysiological (10 microM) concentrations, we investigated the ability of quercetin and its predominant human metabolites to attenuate the expression of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 (MCP-1) in human umbilical artery smooth muscle cells (HUASMC) activated by tumor necrosis factor-alpha (TNFalpha)." ], "offsets": [ [ 0, 451 ] ] }, { "id": "DS.d232.s1", "type": "", "text": [ "Quercetin was able to reduce TNFalpha-induced upregulation of VCAM-1, ICAM-1 and MCP-1 at both the protein and transcript (mRNA) level in HUASMC." ], "offsets": [ [ 452, 597 ] ] }, { "id": "DS.d232.s2", "type": "", "text": [ "However the quercetin metabolites, quercetin 3'-sulfate, quercetin 3-glucuronide and 3'-methylquercetin 3-glucuronide, had no effect on TNFalpha-induced up regulation of adhesion molecule or chemokine expression, at either concentration tested." ], "offsets": [ [ 598, 842 ] ] } ]
[ { "id": "DS.d232.s0.e0", "type": "compound", "text": [ "quercetin" ], "offsets": [ [ 131, 140 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280343" } ] }, { "id": "DS.d232.s0.e1", "type": "protein", "text": [ "VCAM-1" ], "offsets": [ [ 245, 251 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P19320" }, { "db_name": "UniProt", "db_id": "P29533" }, { "db_name": "UniProt", "db_id": "P29534" }, { "db_name": "UniProt", "db_id": "Q28260" } ] }, { "id": "DS.d232.s0.e2", "type": "protein", "text": [ "ICAM-1" ], "offsets": [ [ 289, 295 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05362" }, { "db_name": "UniProt", "db_id": "P13597" }, { "db_name": "UniProt", "db_id": "P33729" }, { "db_name": "UniProt", "db_id": "Q00238" }, { "db_name": "UniProt", "db_id": "Q28806" }, { "db_name": "UniProt", "db_id": "Q5NKV4" }, { "db_name": "UniProt", "db_id": "Q5NKV6" }, { "db_name": "UniProt", "db_id": "Q5NKV9" }, { "db_name": "UniProt", "db_id": "Q95132" } ] }, { "id": "DS.d232.s0.e3", "type": "protein", "text": [ "monocyte chemoattractant protein-1" ], "offsets": [ [ 301, 335 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10148" }, { "db_name": "UniProt", "db_id": "P13500" }, { "db_name": "UniProt", "db_id": "P14844" }, { "db_name": "UniProt", "db_id": "P28292" }, { "db_name": "UniProt", "db_id": "P42831" }, { "db_name": "UniProt", "db_id": "P52203" }, { "db_name": "UniProt", "db_id": "P61274" }, { "db_name": "UniProt", "db_id": "P61275" }, { "db_name": "UniProt", "db_id": "Q08782" }, { "db_name": "UniProt", "db_id": "Q9TTQ3" } ] }, { "id": "DS.d232.s0.e4", "type": "protein", "text": [ "MCP-1" ], "offsets": [ [ 337, 342 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10148" }, { "db_name": "UniProt", "db_id": "P13500" }, { "db_name": "UniProt", "db_id": "P14844" }, { "db_name": "UniProt", "db_id": "P28291" }, { "db_name": "UniProt", "db_id": "P28292" }, { "db_name": "UniProt", "db_id": "P42831" }, { "db_name": "UniProt", "db_id": "P52203" }, { "db_name": "UniProt", "db_id": "P61274" }, { "db_name": "UniProt", "db_id": "P61275" }, { "db_name": "UniProt", "db_id": "Q08782" }, { "db_name": "UniProt", "db_id": "Q9TTQ3" } ] }, { "id": "DS.d232.s0.e5", "type": "protein", "text": [ "tumor necrosis factor" ], "offsets": [ [ 412, 433 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q8JFG3" } ] }, { "id": "DS.d232.s0.e6", "type": "protein", "text": [ "TNFalpha" ], "offsets": [ [ 441, 449 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35734" }, { "db_name": "UniProt", "db_id": "O77510" }, { "db_name": "UniProt", "db_id": "O77764" }, { "db_name": "UniProt", "db_id": "P01375" }, { "db_name": "UniProt", "db_id": "P04924" }, { "db_name": "UniProt", "db_id": "P06804" }, { "db_name": "UniProt", "db_id": "P13296" }, { "db_name": "UniProt", "db_id": "P16599" }, { "db_name": "UniProt", "db_id": "P19101" }, { "db_name": "UniProt", "db_id": "P23383" }, { "db_name": "UniProt", "db_id": "P23563" }, { "db_name": 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"db_id": "Q8MKG8" }, { "db_name": "UniProt", "db_id": "Q8WNR1" }, { "db_name": "UniProt", "db_id": "Q9BEA1" } ] }, { "id": "DS.d232.s1.e0", "type": "compound", "text": [ "Quercetin" ], "offsets": [ [ 452, 461 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280343" } ] }, { "id": "DS.d232.s1.e1", "type": "protein", "text": [ "TNFalpha" ], "offsets": [ [ 481, 489 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35734" }, { "db_name": "UniProt", "db_id": "O77510" }, { "db_name": "UniProt", "db_id": "O77764" }, { "db_name": "UniProt", "db_id": "P01375" }, { "db_name": "UniProt", "db_id": "P04924" }, { "db_name": "UniProt", "db_id": "P06804" }, { "db_name": "UniProt", "db_id": "P13296" }, { "db_name": "UniProt", "db_id": "P16599" }, { "db_name": "UniProt", "db_id": "P19101" }, { "db_name": "UniProt", "db_id": "P23383" }, { "db_name": "UniProt", "db_id": "P23563" }, { "db_name": "UniProt", "db_id": "P29553" }, { "db_name": "UniProt", "db_id": "P33620" }, { "db_name": "UniProt", "db_id": "P36939" }, { "db_name": "UniProt", "db_id": "P48094" }, { "db_name": "UniProt", "db_id": "P51435" }, { "db_name": "UniProt", "db_id": "P51742" }, { "db_name": "UniProt", "db_id": "P51743" }, { "db_name": "UniProt", "db_id": "P59684" }, { "db_name": "UniProt", "db_id": "P59693" }, { "db_name": "UniProt", "db_id": "P59694" }, { "db_name": "UniProt", "db_id": "P59695" }, { "db_name": "UniProt", "db_id": "P79337" }, { "db_name": "UniProt", "db_id": "P79374" }, { "db_name": "UniProt", "db_id": "Q06599" }, { "db_name": "UniProt", "db_id": "Q19LH4" }, { "db_name": "UniProt", "db_id": "Q1G1A2" }, { "db_name": "UniProt", "db_id": "Q1WM27" }, { "db_name": "UniProt", "db_id": "Q2MH05" }, { "db_name": "UniProt", "db_id": "Q539C2" }, { "db_name": "UniProt", "db_id": "Q75N23" }, { "db_name": "UniProt", "db_id": "Q8HZD9" }, { "db_name": "UniProt", "db_id": "Q8JFG3" }, { "db_name": "UniProt", "db_id": "Q8MKG8" }, { "db_name": "UniProt", "db_id": "Q8WNR1" }, { "db_name": "UniProt", "db_id": "Q9BEA1" } ] }, { "id": "DS.d232.s1.e2", "type": "protein", "text": [ "VCAM-1" ], "offsets": [ [ 514, 520 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P19320" }, { "db_name": "UniProt", "db_id": "P29533" }, { "db_name": "UniProt", "db_id": "P29534" }, { "db_name": "UniProt", "db_id": "Q28260" } ] }, { "id": "DS.d232.s1.e3", "type": "protein", "text": [ "ICAM-1" ], "offsets": [ [ 522, 528 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05362" }, { "db_name": "UniProt", "db_id": "P13597" }, { "db_name": "UniProt", "db_id": "P33729" }, { "db_name": "UniProt", "db_id": "Q00238" }, { "db_name": "UniProt", "db_id": "Q28806" }, { "db_name": "UniProt", "db_id": "Q5NKV4" }, { "db_name": "UniProt", "db_id": "Q5NKV6" }, { "db_name": "UniProt", "db_id": "Q5NKV9" }, { "db_name": "UniProt", "db_id": "Q95132" } ] }, { "id": "DS.d232.s1.e4", "type": "protein", "text": [ "MCP-1" ], "offsets": [ [ 533, 538 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10148" }, { "db_name": "UniProt", "db_id": "P13500" }, { "db_name": "UniProt", "db_id": "P14844" }, { "db_name": "UniProt", "db_id": "P28291" }, { "db_name": "UniProt", "db_id": "P28292" }, { "db_name": "UniProt", "db_id": "P42831" }, { "db_name": "UniProt", "db_id": "P52203" }, { "db_name": "UniProt", "db_id": "P61274" }, { "db_name": "UniProt", "db_id": "P61275" }, { "db_name": "UniProt", "db_id": "Q08782" }, { "db_name": "UniProt", "db_id": "Q9TTQ3" } ] }, { "id": "DS.d232.s2.e0", "type": "compound", "text": [ "quercetin 3'-sulfate" ], "offsets": [ [ 633, 653 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280362" } ] }, { "id": "DS.d232.s2.e1", "type": "protein", "text": [ "TNFalpha" ], "offsets": [ [ 734, 742 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35734" }, { "db_name": "UniProt", "db_id": "O77510" }, { "db_name": "UniProt", "db_id": "O77764" }, { "db_name": "UniProt", "db_id": "P01375" }, { "db_name": "UniProt", "db_id": "P04924" }, { "db_name": "UniProt", "db_id": "P06804" }, { "db_name": "UniProt", "db_id": "P13296" }, { "db_name": "UniProt", "db_id": "P16599" }, { "db_name": "UniProt", "db_id": "P19101" }, { "db_name": "UniProt", "db_id": "P23383" }, { "db_name": "UniProt", "db_id": "P23563" }, { "db_name": "UniProt", "db_id": "P29553" }, { "db_name": "UniProt", "db_id": "P33620" }, { "db_name": "UniProt", "db_id": "P36939" }, { "db_name": "UniProt", "db_id": "P48094" }, { "db_name": "UniProt", "db_id": "P51435" }, { "db_name": "UniProt", "db_id": "P51742" }, { "db_name": "UniProt", "db_id": "P51743" }, { "db_name": "UniProt", "db_id": "P59684" }, { "db_name": "UniProt", "db_id": "P59693" }, { "db_name": "UniProt", "db_id": "P59694" }, { "db_name": "UniProt", "db_id": "P59695" }, { "db_name": "UniProt", "db_id": "P79337" }, { "db_name": "UniProt", "db_id": "P79374" }, { "db_name": "UniProt", "db_id": "Q06599" }, { "db_name": "UniProt", "db_id": "Q19LH4" }, { "db_name": "UniProt", "db_id": "Q1G1A2" }, { "db_name": "UniProt", "db_id": "Q1WM27" }, { "db_name": "UniProt", "db_id": "Q2MH05" }, { "db_name": "UniProt", "db_id": "Q539C2" }, { "db_name": "UniProt", "db_id": "Q75N23" }, { "db_name": "UniProt", "db_id": "Q8HZD9" }, { "db_name": "UniProt", "db_id": "Q8JFG3" }, { "db_name": "UniProt", "db_id": "Q8MKG8" }, { "db_name": "UniProt", "db_id": "Q8WNR1" }, { "db_name": "UniProt", "db_id": "Q9BEA1" } ] } ]
[]
[]
[ { "id": "DS.d232.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d232.s1.e0", "arg2_id": "DS.d232.s1.e1", "normalized": [] }, { "id": "DS.d232.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d232.s1.e0", "arg2_id": "DS.d232.s1.e3", "normalized": [] }, { "id": "DS.d232.s1.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d232.s1.e0", "arg2_id": "DS.d232.s1.e4", "normalized": [] }, { "id": "DS.d232.s1.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d232.s1.e0", "arg2_id": "DS.d232.s1.e2", "normalized": [] } ]
DS.d233
18490188
[ { "id": "DS.d233.s0", "type": "", "text": [ "In its active form, thiamin pyrophosphate (TPP), it is a co-enzyme for several enzymes, including transketolase." ], "offsets": [ [ 0, 112 ] ] } ]
[ { "id": "DS.d233.s0.e0", "type": "compound", "text": [ "thiamin pyrophosphate" ], "offsets": [ [ 20, 41 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1132" } ] }, { "id": "DS.d233.s0.e1", "type": "protein", "text": [ "transketolase" ], "offsets": [ [ 98, 111 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O06811" }, { "db_name": "UniProt", "db_id": "O67642" }, { "db_name": "UniProt", "db_id": "O83571" }, { "db_name": "UniProt", "db_id": "P29277" }, { "db_name": "UniProt", "db_id": "P29401" }, { "db_name": "UniProt", "db_id": "P34736" }, { "db_name": "UniProt", "db_id": "P40142" }, { "db_name": "UniProt", "db_id": "P43757" }, { "db_name": "UniProt", "db_id": "P45694" }, { "db_name": "UniProt", "db_id": "P46708" }, { "db_name": "UniProt", "db_id": "P47312" }, { "db_name": "UniProt", "db_id": "P50137" }, { "db_name": "UniProt", "db_id": "P51010" }, { "db_name": "UniProt", "db_id": "P56900" }, { "db_name": "UniProt", "db_id": "P57195" }, { "db_name": "UniProt", "db_id": "P58333" }, { "db_name": "UniProt", "db_id": "P59956" }, { "db_name": "UniProt", "db_id": "P66962" }, { "db_name": "UniProt", "db_id": "P66963" }, { "db_name": "UniProt", "db_id": "P75611" }, { "db_name": "UniProt", "db_id": "P84540" }, { "db_name": "UniProt", "db_id": "P99161" }, { "db_name": "UniProt", "db_id": "Q12630" }, { "db_name": "UniProt", "db_id": "Q52723" }, { "db_name": "UniProt", "db_id": "Q5HG77" }, { "db_name": "UniProt", "db_id": "Q5HPJ9" }, { "db_name": "UniProt", "db_id": "Q5R1W6" }, { "db_name": "UniProt", "db_id": "Q5R4C1" }, { "db_name": "UniProt", "db_id": "Q60HC7" }, { "db_name": "UniProt", "db_id": "Q6B855" }, { "db_name": "UniProt", "db_id": "Q6G9L6" }, { "db_name": "UniProt", "db_id": "Q6GH64" }, { "db_name": "UniProt", "db_id": "Q89AY2" }, { "db_name": "UniProt", "db_id": "Q8CPC7" }, { "db_name": "UniProt", "db_id": "Q8KA26" }, { "db_name": "UniProt", "db_id": "Q9KAD7" } ] } ]
[]
[]
[ { "id": "DS.d233.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d233.s0.e0", "arg2_id": "DS.d233.s0.e1", "normalized": [] } ]
DS.d234
18492032
[ { "id": "DS.d234.s0", "type": "", "text": [ "Coexpression pattern with VDR provides an indication that calcitriol could be the modulator of these adaptive responses to involution and dietary P restriction." ], "offsets": [ [ 0, 160 ] ] } ]
[ { "id": "DS.d234.s0.e0", "type": "protein", "text": [ "VDR" ], "offsets": [ [ 26, 29 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O13124" }, { "db_name": "UniProt", "db_id": "O42392" }, { "db_name": "UniProt", "db_id": "P11473" }, { "db_name": "UniProt", "db_id": "P13053" }, { "db_name": "UniProt", "db_id": "P48281" }, { "db_name": "UniProt", "db_id": "P49701" }, { "db_name": "UniProt", "db_id": "Q28037" }, { "db_name": "UniProt", "db_id": "Q95MH5" } ] }, { "id": "DS.d234.s0.e1", "type": "compound", "text": [ "calcitriol" ], "offsets": [ [ 58, 68 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280453" } ] } ]
[]
[]
[ { "id": "DS.d234.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d234.s0.e1", "arg2_id": "DS.d234.s0.e0", "normalized": [] } ]
DS.d235
18492301
[ { "id": "DS.d235.s0", "type": "", "text": [ "Dietary chia seed (Salvia hispanica L.) rich in alpha-linolenic acid improves adiposity and normalises hypertriacylglycerolaemia and insulin resistance in dyslipaemic rats." ], "offsets": [ [ 0, 172 ] ] }, { "id": "DS.d235.s1", "type": "", "text": [ "The present study investigates the benefits of the dietary intake of chia seed (Salvia hispanica L.) rich in alpha-linolenic acid and fibre upon dyslipidaemia and insulin resistance (IR), induced by intake of a sucrose-rich (62.5 %) diet (SRD)." ], "offsets": [ [ 173, 417 ] ] } ]
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[]
[]
[ { "id": "DS.d235.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d235.s0.e0", "arg2_id": "DS.d235.s0.e1", "normalized": [] } ]
DS.d236
18492302
[ { "id": "DS.d236.s0", "type": "", "text": [ "Pigs fed the high-lysine diet moreover had an increased concentration of trimethyllysine (TML), a reduced mRNA abundance of TML dioxygenase and reduced concentrations of gamma-butyrobetaine (BB) in muscle, indicating that the conversion of TML into BB in muscle was impaired." ], "offsets": [ [ 0, 275 ] ] } ]
[ { "id": "DS.d236.s0.e0", "type": "compound", "text": [ "lysine" ], "offsets": [ [ 18, 24 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "866" }, { "db_name": "PubChem", "db_id": "5962" } ] }, { "id": "DS.d236.s0.e1", "type": "compound", "text": [ "trimethyllysine" ], "offsets": [ [ 73, 88 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "440121" } ] }, { "id": "DS.d236.s0.e2", "type": "protein", "text": [ "TML dioxygenase" ], "offsets": [ [ 124, 139 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q0VC74" }, { "db_name": "UniProt", "db_id": "Q5F4B3" }, { "db_name": "UniProt", "db_id": "Q91ZE0" }, { "db_name": "UniProt", "db_id": "Q91ZW6" }, { "db_name": "UniProt", "db_id": "Q96UB1" }, { "db_name": "UniProt", "db_id": "Q9NVH6" } ] }, { "id": "DS.d236.s0.e3", "type": "compound", "text": [ "gamma-butyrobetaine" ], "offsets": [ [ 170, 189 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "134" } ] } ]
[]
[]
[]
DS.d237
18494609
[ { "id": "DS.d237.s0", "type": "", "text": [ "The cells exposed to 10 microM (15S)-HPETE for 3 h or to 40 microM (15S)-HETE for 6 h showed increased expression of Fas ligand and FADD (Fas-associated death domain), caspase 8 activation, Bid (BH3-interacting domain death agonist) cleavage, decrease in mitochondrial membrane potential, cytochrome c release, caspase 3 activation, PARP-1 (poly(ADP-ribose) polymerase-1) cleavage and DNA fragmentation, suggesting the involvement of both extrinsic and intrinsic death pathways." ], "offsets": [ [ 0, 478 ] ] } ]
[ { "id": "DS.d237.s0.e0", "type": "compound", "text": [ "15S)-HPETE" ], "offsets": [ [ 32, 42 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280893" } ] }, { "id": "DS.d237.s0.e1", "type": "compound", "text": [ "15S)-HETE" ], "offsets": [ [ 68, 77 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280724" } ] }, { "id": "DS.d237.s0.e2", "type": "protein", "text": [ "Fas ligand" ], "offsets": [ [ 117, 127 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P36940" }, { "db_name": "UniProt", "db_id": "P41047" }, { "db_name": "UniProt", "db_id": "P48023" }, { "db_name": "UniProt", "db_id": "P63306" }, { "db_name": "UniProt", "db_id": "P63307" }, { "db_name": "UniProt", "db_id": "P63308" }, { "db_name": "UniProt", "db_id": "Q861W5" }, { "db_name": "UniProt", "db_id": "Q9BDN1" }, { "db_name": "UniProt", "db_id": "Q9BEA8" } ] }, { "id": "DS.d237.s0.e3", "type": "protein", "text": [ "FADD" ], "offsets": [ [ 132, 136 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P46310" }, { "db_name": "UniProt", "db_id": "Q13158" } ] }, { "id": "DS.d237.s0.e4", "type": "protein", "text": [ "Fas" ], "offsets": [ [ 117, 120 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P25446" }, { "db_name": "UniProt", "db_id": "Q63199" } ] }, { "id": "DS.d237.s0.e5", "type": "protein", "text": [ "BH3-interacting domain death agonist" ], "offsets": [ [ 195, 231 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P55957" }, { "db_name": "UniProt", "db_id": "P70444" }, { "db_name": "UniProt", "db_id": "Q4JHS0" }, { "db_name": "UniProt", "db_id": "Q8JGM8" }, { "db_name": "UniProt", "db_id": "Q9JLT6" } ] }, { "id": "DS.d237.s0.e6", "type": "protein", "text": [ "cytochrome c" ], "offsets": [ [ 289, 301 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O07091" }, { "db_name": "UniProt", "db_id": "O13393" }, { "db_name": "UniProt", "db_id": "O22642" }, { "db_name": "UniProt", "db_id": "O93863" }, { "db_name": "UniProt", "db_id": "P00002" }, { "db_name": "UniProt", 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"db_id": "Q96VP3" } ] }, { "id": "DS.d237.s0.e7", "type": "protein", "text": [ "PARP-1" ], "offsets": [ [ 333, 339 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P09874" }, { "db_name": "UniProt", "db_id": "P11103" }, { "db_name": "UniProt", "db_id": "P18493" }, { "db_name": "UniProt", "db_id": "P26446" }, { "db_name": "UniProt", "db_id": "P27008" }, { "db_name": "UniProt", "db_id": "Q7EYV7" }, { "db_name": "UniProt", "db_id": "Q9R152" }, { "db_name": "UniProt", "db_id": "Q9ZP54" }, { "db_name": "UniProt", "db_id": "Q9ZSV1" } ] }, { "id": "DS.d237.s0.e8", "type": "protein", "text": [ "ADP" ], "offsets": [ [ 346, 349 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02783" } ] } ]
[]
[]
[ { "id": "DS.d237.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d237.s0.e0", "arg2_id": "DS.d237.s0.e3", "normalized": [] }, { "id": "DS.d237.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d237.s0.e0", "arg2_id": "DS.d237.s0.e4", "normalized": [] }, { "id": "DS.d237.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d237.s0.e1", "arg2_id": "DS.d237.s0.e5", "normalized": [] }, { "id": "DS.d237.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d237.s0.e1", "arg2_id": "DS.d237.s0.e4", "normalized": [] }, { "id": "DS.d237.s0.i4", "type": "compound-protein-interaction", "arg1_id": "DS.d237.s0.e1", "arg2_id": "DS.d237.s0.e8", "normalized": [] }, { "id": "DS.d237.s0.i5", "type": "compound-protein-interaction", "arg1_id": "DS.d237.s0.e1", "arg2_id": "DS.d237.s0.e6", "normalized": [] }, { "id": "DS.d237.s0.i6", "type": "compound-protein-interaction", "arg1_id": "DS.d237.s0.e1", "arg2_id": "DS.d237.s0.e2", "normalized": [] }, { "id": "DS.d237.s0.i7", "type": "compound-protein-interaction", "arg1_id": "DS.d237.s0.e0", "arg2_id": "DS.d237.s0.e2", "normalized": [] }, { "id": "DS.d237.s0.i8", "type": "compound-protein-interaction", "arg1_id": "DS.d237.s0.e1", "arg2_id": "DS.d237.s0.e3", "normalized": [] }, { "id": "DS.d237.s0.i9", "type": "compound-protein-interaction", "arg1_id": "DS.d237.s0.e0", "arg2_id": "DS.d237.s0.e8", "normalized": [] }, { "id": "DS.d237.s0.i10", "type": "compound-protein-interaction", "arg1_id": "DS.d237.s0.e1", "arg2_id": "DS.d237.s0.e7", "normalized": [] }, { "id": "DS.d237.s0.i11", "type": "compound-protein-interaction", "arg1_id": "DS.d237.s0.e0", "arg2_id": "DS.d237.s0.e6", "normalized": [] }, { "id": "DS.d237.s0.i12", "type": "compound-protein-interaction", "arg1_id": "DS.d237.s0.e0", "arg2_id": "DS.d237.s0.e5", "normalized": [] }, { "id": "DS.d237.s0.i13", "type": "compound-protein-interaction", "arg1_id": "DS.d237.s0.e0", "arg2_id": "DS.d237.s0.e7", "normalized": [] } ]
DS.d238
18495128
[ { "id": "DS.d238.s0", "type": "", "text": [ "3-Deazaadenosine inhibits vasa vasorum neovascularization in aortas of ApoE (-/-)/LDL(-/-) double knockout mice." ], "offsets": [ [ 0, 112 ] ] } ]
[ { "id": "DS.d238.s0.e0", "type": "compound", "text": [ "3-Deazaadenosine" ], "offsets": [ [ 0, 16 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1651" }, { "db_name": "PubChem", "db_id": "23190" } ] }, { "id": "DS.d238.s0.e1", "type": "protein", "text": [ "ApoE" ], "offsets": [ [ 71, 75 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02649" }, { "db_name": "UniProt", "db_id": "P02650" }, { "db_name": "UniProt", "db_id": "P05770" }, { "db_name": "UniProt", "db_id": "P08226" }, { "db_name": "UniProt", "db_id": "P10517" }, { "db_name": "UniProt", "db_id": "P18287" }, { "db_name": "UniProt", "db_id": "P18649" }, { "db_name": "UniProt", "db_id": "P18650" }, { "db_name": "UniProt", "db_id": "P23529" }, { "db_name": "UniProt", "db_id": "Q03247" }, { "db_name": "UniProt", "db_id": "Q28502" }, { "db_name": "UniProt", "db_id": "Q28995" }, { "db_name": "UniProt", "db_id": "Q7M2U7" }, { "db_name": "UniProt", "db_id": "Q7M2U8" }, { "db_name": "UniProt", "db_id": "Q9GJU3" }, { "db_name": "UniProt", "db_id": "Q9GLC0" }, { "db_name": "UniProt", "db_id": "Q9GLM6" }, { "db_name": "UniProt", "db_id": "Q9GLM7" }, { "db_name": "UniProt", "db_id": "Q9GLM8" } ] } ]
[]
[]
[]
DS.d239
18495129
[ { "id": "DS.d239.s0", "type": "", "text": [ "Anthocyanin attenuates CD40-mediated endothelial cell activation and apoptosis by inhibiting CD40-induced MAPK activation." ], "offsets": [ [ 0, 122 ] ] }, { "id": "DS.d239.s1", "type": "", "text": [ "Treatment of ECs with anthocyanins cyanidin-3-O-beta-glucoside (Cy-3-g) and peonidin-3-O-beta-glucoside (Pn-3-g) prevents CD40-induced endothelial activation by inhibiting production of proinflammatory cytokines and matrix metalloproteinases (MMPs)." ], "offsets": [ [ 123, 372 ] ] }, { "id": "DS.d239.s2", "type": "", "text": [ "Collectively, our findings suggested that the inhibition of JNK and p38 activation interrupts CD40 induced endothelial cell activation and apoptosis, which thereby may represent a mechanism that would explain the anti-inflammatory response of anthocyanin and its athero-protective function." ], "offsets": [ [ 373, 663 ] ] } ]
[ { "id": "DS.d239.s0.e0", "type": "compound", "text": [ "Anthocyanin" ], "offsets": [ [ 0, 11 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "145858" } ] }, { "id": "DS.d239.s0.e1", "type": "protein", "text": [ "CD40" ], "offsets": [ [ 23, 27 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P25942" }, { "db_name": "UniProt", "db_id": "Q28203" }, { "db_name": "UniProt", "db_id": "Q3LRP1" }, { "db_name": "UniProt", "db_id": "Q3ZTK5" }, { "db_name": "UniProt", "db_id": "Q7YRL5" }, { "db_name": "UniProt", "db_id": "Q8SQ34" } ] }, { "id": "DS.d239.s0.e2", "type": "protein", "text": [ "CD40" ], "offsets": [ [ 93, 97 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P25942" }, { "db_name": "UniProt", "db_id": "Q28203" }, { "db_name": "UniProt", "db_id": "Q3LRP1" }, { "db_name": "UniProt", "db_id": "Q3ZTK5" }, { "db_name": "UniProt", "db_id": "Q7YRL5" }, { "db_name": "UniProt", "db_id": "Q8SQ34" } ] }, { "id": "DS.d239.s0.e3", "type": "protein", "text": [ "MAPK" ], "offsets": [ [ 106, 110 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42781" }, { "db_name": "UniProt", "db_id": "P27638" }, { "db_name": "UniProt", "db_id": "Q00859" } ] }, { "id": "DS.d239.s1.e0", "type": "compound", "text": [ "peonidin-3-O-beta-glucoside" ], "offsets": [ [ 199, 226 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "53398755" } ] }, { "id": "DS.d239.s1.e1", "type": "protein", "text": [ "CD40" ], "offsets": [ [ 245, 249 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P25942" }, { "db_name": "UniProt", "db_id": "Q28203" }, { "db_name": "UniProt", "db_id": "Q3LRP1" }, { "db_name": "UniProt", "db_id": "Q3ZTK5" }, { "db_name": "UniProt", "db_id": "Q7YRL5" }, { "db_name": "UniProt", "db_id": "Q8SQ34" } ] }, { "id": "DS.d239.s2.e0", "type": "protein", "text": [ "JNK" ], "offsets": [ [ 433, 436 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P92208" }, { "db_name": "UniProt", "db_id": "Q966Y3" } ] }, { "id": "DS.d239.s2.e1", "type": "protein", "text": [ "p38" ], "offsets": [ [ 441, 444 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O24473" }, { "db_name": "UniProt", "db_id": "O75791" }, { "db_name": "UniProt", "db_id": "O95433" }, { "db_name": "UniProt", "db_id": "O97628" }, { "db_name": "UniProt", "db_id": "P46108" }, { "db_name": "UniProt", "db_id": "P80350" }, { "db_name": "UniProt", "db_id": "P82869" }, { "db_name": "UniProt", "db_id": "Q01552" }, { "db_name": "UniProt", "db_id": "Q04929" }, { "db_name": "UniProt", "db_id": "Q63768" }, { "db_name": "UniProt", "db_id": "Q64010" }, { "db_name": "UniProt", "db_id": "Q9LDA4" }, { "db_name": "UniProt", "db_id": "Q9Y2S7" } ] }, { "id": "DS.d239.s2.e2", "type": "protein", "text": [ "CD40" ], "offsets": [ [ 467, 471 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P25942" }, { "db_name": "UniProt", "db_id": "Q28203" }, { "db_name": "UniProt", "db_id": "Q3LRP1" }, { "db_name": "UniProt", "db_id": "Q3ZTK5" }, { "db_name": "UniProt", "db_id": "Q7YRL5" }, { "db_name": "UniProt", "db_id": "Q8SQ34" } ] }, { "id": "DS.d239.s2.e3", "type": "compound", "text": [ "anthocyanin" ], "offsets": [ [ 616, 627 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "145858" } ] } ]
[]
[]
[ { "id": "DS.d239.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d239.s0.e0", "arg2_id": "DS.d239.s0.e3", "normalized": [] }, { "id": "DS.d239.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d239.s0.e0", "arg2_id": "DS.d239.s0.e1", "normalized": [] }, { "id": "DS.d239.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d239.s1.e0", "arg2_id": "DS.d239.s1.e1", "normalized": [] }, { "id": "DS.d239.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d239.s2.e3", "arg2_id": "DS.d239.s2.e1", "normalized": [] }, { "id": "DS.d239.s2.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d239.s2.e3", "arg2_id": "DS.d239.s2.e0", "normalized": [] }, { "id": "DS.d239.s2.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d239.s2.e3", "arg2_id": "DS.d239.s2.e2", "normalized": [] } ]
DS.d240
18495357
[ { "id": "DS.d240.s0", "type": "", "text": [ "Postsynaptic action of ATP is mediated through metabotropic P2Y and ionotropic P2X receptors abundantly expressed in neural cells." ], "offsets": [ [ 0, 130 ] ] } ]
[ { "id": "DS.d240.s0.e0", "type": "compound", "text": [ "ATP" ], "offsets": [ [ 23, 26 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5957" } ] }, { "id": "DS.d240.s0.e1", "type": "protein", "text": [ "P2X" ], "offsets": [ [ 79, 82 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P13900" }, { "db_name": "UniProt", "db_id": "P16604" } ] } ]
[]
[]
[ { "id": "DS.d240.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d240.s0.e0", "arg2_id": "DS.d240.s0.e1", "normalized": [] } ]
DS.d241
18495456
[ { "id": "DS.d241.s0", "type": "", "text": [ "However, the MTHFR C677T genotype, alone or together with a diet, influenced betaine (P=.03) and phosphatidylcholine (P=.03)." ], "offsets": [ [ 0, 125 ] ] }, { "id": "DS.d241.s1", "type": "", "text": [ "In addition, the MTHFR C677T genotype appears to influence the direction and use of choline moieties in this group of women." ], "offsets": [ [ 126, 250 ] ] } ]
[ { "id": "DS.d241.s0.e0", "type": "protein", "text": [ "MTHFR" ], "offsets": [ [ 13, 18 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P42898" }, { "db_name": "UniProt", "db_id": "Q5I598" }, { "db_name": "UniProt", "db_id": "Q60HE5" } ] }, { "id": "DS.d241.s0.e1", "type": "compound", "text": [ "betaine" ], "offsets": [ [ 77, 84 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "248" } ] }, { "id": "DS.d241.s1.e0", "type": "protein", "text": [ "MTHFR" ], "offsets": [ [ 143, 148 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P42898" }, { "db_name": "UniProt", "db_id": "Q5I598" }, { "db_name": "UniProt", "db_id": "Q60HE5" } ] }, { "id": "DS.d241.s1.e1", "type": "compound", "text": [ "choline" ], "offsets": [ [ 210, 217 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "305" } ] } ]
[]
[]
[ { "id": "DS.d241.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d241.s0.e1", "arg2_id": "DS.d241.s0.e0", "normalized": [] }, { "id": "DS.d241.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d241.s1.e1", "arg2_id": "DS.d241.s1.e0", "normalized": [] } ]
DS.d242
18495458
[ { "id": "DS.d242.s0", "type": "", "text": [ "Epicatechin-induced survival was a rapid event that was accompanied by early and sustained activation of major survival signaling proteins, such as AKT/phosphatidylinositol 3-kinase and extracellular-regulated kinase (activated from 5 min to 18 h), as well as protein kinase C (PKC)-alpha (30 min to 18 h), in concert with unaltered c-jun N-amino terminal kinase levels and early inactivation of key death-related signals like PKC-delta (5 min to 18 h)." ], "offsets": [ [ 0, 453 ] ] } ]
[ { "id": "DS.d242.s0.e0", "type": "compound", "text": [ "Epicatechin" ], "offsets": [ [ 0, 11 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1203" }, { "db_name": "PubChem", "db_id": "72276" }, { "db_name": "PubChem", "db_id": "182232" } ] }, { "id": "DS.d242.s0.e1", "type": "protein", "text": [ "protein kinase C" ], "offsets": [ [ 260, 276 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P13678" }, { "db_name": "UniProt", "db_id": "Q25378" } ] }, { "id": "DS.d242.s0.e2", "type": "protein", "text": [ "PKC" ], "offsets": [ [ 278, 281 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05130" }, { "db_name": "UniProt", "db_id": "P13677" }, { "db_name": "UniProt", "db_id": "P13678" }, { "db_name": "UniProt", "db_id": "P34722" } ] }, { "id": "DS.d242.s0.e3", "type": "protein", "text": [ "jun" ], "offsets": [ [ 335, 338 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05627" }, { "db_name": "UniProt", "db_id": "P17325" }, { "db_name": "UniProt", "db_id": "P18289" } ] }, { "id": "DS.d242.s0.e4", "type": "protein", "text": [ "PKC-delta" ], "offsets": [ [ 427, 436 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10829" } ] } ]
[]
[]
[ { "id": "DS.d242.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d242.s0.e0", "arg2_id": "DS.d242.s0.e3", "normalized": [] }, { "id": "DS.d242.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d242.s0.e0", "arg2_id": "DS.d242.s0.e2", "normalized": [] }, { "id": "DS.d242.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d242.s0.e0", "arg2_id": "DS.d242.s0.e4", "normalized": [] }, { "id": "DS.d242.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d242.s0.e0", "arg2_id": "DS.d242.s0.e1", "normalized": [] } ]
DS.d243
18495460
[ { "id": "DS.d243.s0", "type": "", "text": [ "Phospholipidosis and down-regulation of the PI3-K/PDK-1/Akt signalling pathway are vitamin E inhibitable events associated with 7-ketocholesterol-induced apoptosis." ], "offsets": [ [ 0, 164 ] ] } ]
[ { "id": "DS.d243.s0.e0", "type": "protein", "text": [ "PI3" ], "offsets": [ [ 44, 47 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P19957" } ] }, { "id": "DS.d243.s0.e1", "type": "protein", "text": [ "PDK" ], "offsets": [ [ 50, 53 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P22221" }, { "db_name": "UniProt", "db_id": "Q42736" } ] }, { "id": "DS.d243.s0.e2", "type": "protein", "text": [ "Akt" ], "offsets": [ [ 56, 59 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P31750" }, { "db_name": "UniProt", "db_id": "Q8INB9" } ] }, { "id": "DS.d243.s0.e3", "type": "compound", "text": [ "vitamin E" ], "offsets": [ [ 83, 92 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2116" }, { "db_name": "PubChem", "db_id": "14985" }, { "db_name": "PubChem", "db_id": "1548900" }, { "db_name": "PubChem", "db_id": "1742129" } ] } ]
[]
[]
[ { "id": "DS.d243.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d243.s0.e3", "arg2_id": "DS.d243.s0.e0", "normalized": [] }, { "id": "DS.d243.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d243.s0.e3", "arg2_id": "DS.d243.s0.e2", "normalized": [] }, { "id": "DS.d243.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d243.s0.e3", "arg2_id": "DS.d243.s0.e1", "normalized": [] } ]
DS.d244
18495461
[ { "id": "DS.d244.s0", "type": "", "text": [ "Lack of vitamin A significantly changed mucin (MUC) dynamics, as reflected by the enlarged goblet-cell \"cup\" area relative to controls; decreased MUC2 mRNA expression in the jejunum, ileum and colon of VAD rats and increased MUC3 mRNA expression in the ileum and colon of these rats." ], "offsets": [ [ 0, 283 ] ] }, { "id": "DS.d244.s1", "type": "", "text": [ "In addition, vitamin A deficiency down-regulated defensin 6 mRNA expression while up-regulating toll-like receptors 2 and 5 mRNA expressions." ], "offsets": [ [ 284, 425 ] ] } ]
[ { "id": "DS.d244.s0.e0", "type": "compound", "text": [ "vitamin A" ], "offsets": [ [ 8, 17 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "445354" } ] }, { "id": "DS.d244.s0.e1", "type": "protein", "text": [ "MUC2" ], "offsets": [ [ 146, 150 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q02817" } ] }, { "id": "DS.d244.s0.e2", "type": "protein", "text": [ "MUC3" ], "offsets": [ [ 225, 229 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q02505" } ] }, { "id": "DS.d244.s1.e0", "type": "compound", "text": [ "vitamin A" ], "offsets": [ [ 297, 306 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "445354" } ] }, { "id": "DS.d244.s1.e1", "type": "protein", "text": [ "defensin" ], "offsets": [ [ 333, 341 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P17722" }, { "db_name": "UniProt", "db_id": "P37364" }, { "db_name": "UniProt", "db_id": "P80154" }, { "db_name": "UniProt", "db_id": "P80407" }, { "db_name": "UniProt", "db_id": "P81462" }, { "db_name": "UniProt", "db_id": "Q10745" } ] } ]
[]
[]
[ { "id": "DS.d244.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d244.s0.e0", "arg2_id": "DS.d244.s0.e1", "normalized": [] }, { "id": "DS.d244.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d244.s0.e0", "arg2_id": "DS.d244.s0.e2", "normalized": [] }, { "id": "DS.d244.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d244.s1.e0", "arg2_id": "DS.d244.s1.e1", "normalized": [] } ]
DS.d245
18495463
[ { "id": "DS.d245.s0", "type": "", "text": [ "Curcumin, demethoxycurcumin and bisdemethoxycurcumin differentially inhibit cancer cell invasion through the down-regulation of MMPs and uPA." ], "offsets": [ [ 0, 141 ] ] } ]
[ { "id": "DS.d245.s0.e0", "type": "compound", "text": [ "Curcumin" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "969516" } ] }, { "id": "DS.d245.s0.e1", "type": "compound", "text": [ "demethoxycurcumin" ], "offsets": [ [ 10, 27 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5324476" } ] }, { "id": "DS.d245.s0.e2", "type": "compound", "text": [ "bisdemethoxycurcumin" ], "offsets": [ [ 32, 52 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5315472" } ] }, { "id": "DS.d245.s0.e3", "type": "protein", "text": [ "uPA" ], "offsets": [ [ 137, 140 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P00749" }, { "db_name": "UniProt", "db_id": "P04185" }, { "db_name": "UniProt", "db_id": "P06869" }, { "db_name": "UniProt", "db_id": "P15120" }, { "db_name": "UniProt", "db_id": "P16227" }, { "db_name": "UniProt", "db_id": "P29598" }, { "db_name": "UniProt", "db_id": "Q05589" } ] } ]
[]
[]
[ { "id": "DS.d245.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d245.s0.e0", "arg2_id": "DS.d245.s0.e3", "normalized": [] }, { "id": "DS.d245.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d245.s0.e2", "arg2_id": "DS.d245.s0.e3", "normalized": [] }, { "id": "DS.d245.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d245.s0.e1", "arg2_id": "DS.d245.s0.e3", "normalized": [] } ]
DS.d246
18496518
[ { "id": "DS.d246.s0", "type": "", "text": [ "Glucocorticoid receptor antagonism augments fluoxetine-induced downregulation of the 5-HT transporter." ], "offsets": [ [ 0, 102 ] ] }, { "id": "DS.d246.s1", "type": "", "text": [ "In contrast, chronic fluoxetine markedly decreased 5-HTT levels in all regions." ], "offsets": [ [ 103, 182 ] ] }, { "id": "DS.d246.s2", "type": "", "text": [ "This downregulation of 5-HTT by fluoxetine and its enhancement by Org 34850 can explain our recent observation that GR antagonists augment the SSRI-induced increase in extracellular 5-HT." ], "offsets": [ [ 183, 370 ] ] } ]
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[]
[]
[ { "id": "DS.d246.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d246.s0.e1", "arg2_id": "DS.d246.s0.e0", "normalized": [] }, { "id": "DS.d246.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d246.s1.e0", "arg2_id": "DS.d246.s1.e1", "normalized": [] }, { "id": "DS.d246.s2.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d246.s2.e1", "arg2_id": "DS.d246.s2.e0", "normalized": [] } ]
DS.d247
18496650
[ { "id": "DS.d247.s0", "type": "", "text": [ "Moreover, intestinal, colonic and caecal TBARS, LOOH, CD and also the antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR) and reduced glutathione (GSH) were significantly diminished in DMH 0.05) elevated on simultaneous morin supplementation." ], "offsets": [ [ 0, 337 ] ] } ]
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"Q6G9M4" }, { "db_name": "UniProt", "db_id": "Q6GH72" }, { "db_name": "UniProt", "db_id": "Q7A5T2" }, { "db_name": "UniProt", "db_id": "Q8CPD0" }, { "db_name": "UniProt", "db_id": "Q8FWU0" }, { "db_name": "UniProt", "db_id": "Q8NWV5" }, { "db_name": "UniProt", "db_id": "Q8X1P0" }, { "db_name": "UniProt", "db_id": "Q8Y3P9" }, { "db_name": "UniProt", "db_id": "Q926X0" }, { "db_name": "UniProt", "db_id": "Q99UE2" }, { "db_name": "UniProt", "db_id": "Q9AXH0" }, { "db_name": "UniProt", "db_id": "Q9KW19" }, { "db_name": "UniProt", "db_id": "Q9L4S1" }, { "db_name": "UniProt", "db_id": "Q9M5L6" }, { "db_name": "UniProt", "db_id": "Q9PT92" }, { "db_name": "UniProt", "db_id": "Q9PWF7" }, { "db_name": "UniProt", "db_id": "Q9Z598" }, { "db_name": "UniProt", "db_id": "Q9ZKX5" }, { "db_name": "UniProt", "db_id": "Q9ZN99" } ] }, { "id": "DS.d247.s0.e3", "type": "protein", "text": [ "CAT" ], "offsets": [ [ 121, 124 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62839" }, { "db_name": "UniProt", "db_id": "O97492" }, { "db_name": "UniProt", "db_id": "P00432" }, { "db_name": "UniProt", "db_id": "P00485" }, { "db_name": "UniProt", "db_id": "P00486" }, { "db_name": "UniProt", "db_id": "P00487" }, { "db_name": "UniProt", "db_id": "P04040" }, { "db_name": "UniProt", "db_id": "P06135" }, { "db_name": "UniProt", "db_id": "P07641" }, { "db_name": "UniProt", "db_id": "P11504" }, { "db_name": "UniProt", "db_id": "P20074" }, { "db_name": "UniProt", "db_id": "P22782" }, { "db_name": "UniProt", "db_id": "P25309" }, { "db_name": "UniProt", "db_id": "P25819" }, { "db_name": "UniProt", "db_id": "P26825" }, { "db_name": "UniProt", "db_id": "P26826" }, { "db_name": "UniProt", "db_id": "P32796" }, { "db_name": "UniProt", "db_id": "P36882" }, { "db_name": "UniProt", "db_id": "P36883" }, { "db_name": "UniProt", "db_id": "P43155" }, { "db_name": "UniProt", "db_id": "P47934" }, { "db_name": "UniProt", "db_id": "P49417" }, { "db_name": "UniProt", "db_id": "P52826" }, { "db_name": "UniProt", "db_id": "P58777" }, { "db_name": "UniProt", "db_id": "P62577" }, { "db_name": "UniProt", "db_id": "P62578" }, { "db_name": "UniProt", "db_id": "P62579" }, { "db_name": "UniProt", "db_id": "P62580" }, { "db_name": "UniProt", "db_id": "P90682" }, { "db_name": "UniProt", "db_id": "Q00614" }, { "db_name": "UniProt", "db_id": "Q02736" }, { "db_name": "UniProt", "db_id": "Q03058" }, { "db_name": "UniProt", "db_id": "Q5RF10" }, { "db_name": "UniProt", "db_id": "Q64405" }, { "db_name": "UniProt", "db_id": "Q704S8" }, { "db_name": "UniProt", "db_id": "Q9M5L6" }, { "db_name": "UniProt", "db_id": "Q9PWF7" } ] }, { "id": "DS.d247.s0.e4", "type": "protein", "text": [ "glutathione S-transferase" ], "offsets": [ [ 127, 152 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O04437" }, { "db_name": "UniProt", "db_id": "O18598" }, { "db_name": "UniProt", "db_id": "P0A9D2" }, { "db_name": "UniProt", "db_id": "P0A9D3" }, { "db_name": "UniProt", "db_id": "P30116" }, { "db_name": "UniProt", "db_id": "P44521" }, { "db_name": "UniProt", "db_id": "P46088" }, { "db_name": "UniProt", "db_id": "P46419" }, { "db_name": "UniProt", "db_id": "P46423" }, { "db_name": "UniProt", "db_id": "P46426" }, { "db_name": "UniProt", "db_id": "P46428" }, { "db_name": "UniProt", "db_id": "P46437" }, { "db_name": "UniProt", "db_id": "P48438" }, { "db_name": "UniProt", "db_id": "P80894" }, { "db_name": "UniProt", "db_id": "P81065" }, { "db_name": "UniProt", "db_id": "P82996" }, { "db_name": "UniProt", "db_id": "P82997" }, { "db_name": "UniProt", "db_id": "P82998" }, { "db_name": "UniProt", "db_id": "P82999" }, { "db_name": "UniProt", "db_id": "P83000" }, { "db_name": "UniProt", "db_id": "P83001" }, { "db_name": "UniProt", "db_id": "P83246" }, { "db_name": "UniProt", "db_id": "Q04522" }, { "db_name": "UniProt", "db_id": "Q08392" }, { "db_name": "UniProt", "db_id": "Q08393" }, { "db_name": "UniProt", "db_id": "Q0ZS46" }, { "db_name": "UniProt", "db_id": "Q7REH6" }, { "db_name": "UniProt", "db_id": "Q8ILQ7" }, { "db_name": "UniProt", "db_id": "Q8MU52" }, { "db_name": "UniProt", "db_id": "Q96324" } ] }, { "id": "DS.d247.s0.e5", "type": "protein", "text": [ "GST" ], "offsets": [ [ 154, 157 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P20432" }, { "db_name": "UniProt", "db_id": "P30104" }, { "db_name": "UniProt", "db_id": "P30106" }, { "db_name": "UniProt", "db_id": "P30107" }, { "db_name": "UniProt", "db_id": "P30108" }, { "db_name": "UniProt", "db_id": "Q04522" }, { "db_name": "UniProt", "db_id": "Q0ZS46" }, { "db_name": "UniProt", "db_id": "Q7REH6" }, { "db_name": "UniProt", "db_id": "Q8ILQ7" }, { "db_name": "UniProt", "db_id": "Q8MU52" } ] }, { "id": "DS.d247.s0.e6", "type": "protein", "text": [ "glutathione peroxidase" ], "offsets": [ [ 160, 182 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O32770" }, { "db_name": "UniProt", "db_id": "O59858" }, { "db_name": "UniProt", "db_id": "Q00277" }, { "db_name": "UniProt", "db_id": "Q9CFV1" } ] }, { "id": "DS.d247.s0.e7", "type": "protein", "text": [ "glutathione reductase" ], "offsets": [ [ 190, 211 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O15770" }, { "db_name": "UniProt", "db_id": "P06715" }, { "db_name": "UniProt", "db_id": "P11804" }, { "db_name": "UniProt", "db_id": "P23189" }, { "db_name": "UniProt", "db_id": "P41921" }, { "db_name": "UniProt", "db_id": "P43783" }, { "db_name": "UniProt", "db_id": "P48638" }, { "db_name": "UniProt", "db_id": "P48639" }, { "db_name": "UniProt", "db_id": "P70619" }, { "db_name": "UniProt", "db_id": "P78965" }, { "db_name": "UniProt", "db_id": "Q60151" }, { "db_name": "UniProt", "db_id": "Q6BPI1" }, { "db_name": "UniProt", "db_id": "Q6C5H4" }, { "db_name": "UniProt", "db_id": "Q6FRV2" }, { "db_name": "UniProt", "db_id": "Q6HA23" }, { "db_name": "UniProt", "db_id": "Q74ZK4" }, { "db_name": "UniProt", "db_id": "Q873E8" }, { "db_name": "UniProt", "db_id": "Q94655" } ] }, { "id": "DS.d247.s0.e8", "type": "compound", "text": [ "reduced glutathione" ], "offsets": [ [ 221, 240 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d247.s0.e9", "type": "compound", "text": [ "GSH" ], "offsets": [ [ 242, 245 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d247.s0.e10", "type": "compound", "text": [ "morin" ], "offsets": [ [ 315, 320 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5281670" } ] } ]
[]
[]
[ { "id": "DS.d247.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d247.s0.e10", "arg2_id": "DS.d247.s0.e5", "normalized": [] }, { "id": "DS.d247.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d247.s0.e10", "arg2_id": "DS.d247.s0.e3", "normalized": [] }, { "id": "DS.d247.s0.i4", "type": "compound-protein-interaction", "arg1_id": "DS.d247.s0.e10", "arg2_id": "DS.d247.s0.e7", "normalized": [] }, { "id": "DS.d247.s0.i13", "type": "compound-protein-interaction", "arg1_id": "DS.d247.s0.e10", "arg2_id": "DS.d247.s0.e2", "normalized": [] }, { "id": "DS.d247.s0.i15", "type": "compound-protein-interaction", "arg1_id": "DS.d247.s0.e10", "arg2_id": "DS.d247.s0.e4", "normalized": [] }, { "id": "DS.d247.s0.i18", "type": "compound-protein-interaction", "arg1_id": "DS.d247.s0.e10", "arg2_id": "DS.d247.s0.e0", "normalized": [] }, { "id": "DS.d247.s0.i20", "type": "compound-protein-interaction", "arg1_id": "DS.d247.s0.e10", "arg2_id": "DS.d247.s0.e6", "normalized": [] }, { "id": "DS.d247.s0.i22", "type": "compound-protein-interaction", "arg1_id": "DS.d247.s0.e10", "arg2_id": "DS.d247.s0.e1", "normalized": [] } ]
DS.d248
18496767
[ { "id": "DS.d248.s0", "type": "", "text": [ "Using in vitro binding assays we have demonstrated that transcription factors Sp3, ZBP-89 and NF-Y are capable of binding to the SOX18 promoter region spanning the sequence-200 to-162 relative to ATG and that formation of complexes could be efficiently reduced by mithramycin A." ], "offsets": [ [ 0, 278 ] ] } ]
[ { "id": "DS.d248.s0.e0", "type": "protein", "text": [ "transcription factors Sp3" ], "offsets": [ [ 56, 81 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O70494" }, { "db_name": "UniProt", "db_id": "Q02447" }, { "db_name": "UniProt", "db_id": "Q90WR8" } ] }, { "id": "DS.d248.s0.e1", "type": "protein", "text": [ "SOX18" ], "offsets": [ [ 129, 134 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P35713" } ] }, { "id": "DS.d248.s0.e2", "type": "compound", "text": [ "mithramycin A" ], "offsets": [ [ 264, 277 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "29051" }, { "db_name": "PubChem", "db_id": "163659" }, { "db_name": "PubChem", "db_id": "230076" }, { "db_name": "PubChem", "db_id": "6326719" } ] } ]
[]
[]
[ { "id": "DS.d248.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d248.s0.e2", "arg2_id": "DS.d248.s0.e1", "normalized": [] }, { "id": "DS.d248.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d248.s0.e2", "arg2_id": "DS.d248.s0.e0", "normalized": [] } ]
DS.d249
18496861
[ { "id": "DS.d249.s0", "type": "", "text": [ "Treatment with hyaluronidase indicates that the dimensions of the small fibrils may be dependent upon the presence of hyaluronan within the matrix." ], "offsets": [ [ 0, 147 ] ] } ]
[ { "id": "DS.d249.s0.e0", "type": "protein", "text": [ "hyaluronidase" ], "offsets": [ [ 15, 28 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15316" }, { "db_name": "UniProt", "db_id": "P26831" }, { "db_name": "UniProt", "db_id": "P49370" }, { "db_name": "UniProt", "db_id": "P49371" }, { "db_name": "UniProt", "db_id": "Q08169" }, { "db_name": "UniProt", "db_id": "Q53591" }, { "db_name": "UniProt", "db_id": "Q54699" }, { "db_name": "UniProt", "db_id": "Q54873" }, { "db_name": "UniProt", "db_id": "Q59634" }, { "db_name": "UniProt", "db_id": "Q59801" }, { "db_name": "UniProt", "db_id": "Q9U6V9" } ] }, { "id": "DS.d249.s0.e1", "type": "compound", "text": [ "hyaluronan" ], "offsets": [ [ 118, 128 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "24759" } ] } ]
[]
[]
[ { "id": "DS.d249.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d249.s0.e1", "arg2_id": "DS.d249.s0.e0", "normalized": [] } ]
DS.d250
18496865
[ { "id": "DS.d250.s0", "type": "", "text": [ "Tetraglyme coatings reduce fibrinogen and von Willebrand factor adsorption and platelet adhesion under both static and flow conditions." ], "offsets": [ [ 0, 135 ] ] }, { "id": "DS.d250.s1", "type": "", "text": [ "Previous studies have showed that radio-frequency plasma deposited tetraglyme coatings greatly reduced fibrinogen adsorption (Gamma(Fg)) from highly diluted plasmas (0.1 and 1%) and subsequent platelet adhesion under static conditions." ], "offsets": [ [ 136, 371 ] ] } ]
[ { "id": "DS.d250.s0.e0", "type": "compound", "text": [ "Tetraglyme" ], "offsets": [ [ 0, 10 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "8925" } ] }, { "id": "DS.d250.s0.e1", "type": "protein", "text": [ "fibrinogen" ], "offsets": [ [ 27, 37 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P22775" }, { "db_name": "UniProt", "db_id": "P81070" } ] }, { "id": "DS.d250.s0.e2", "type": "protein", "text": [ "von Willebrand factor" ], "offsets": [ [ 42, 63 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q62935" } ] }, { "id": "DS.d250.s1.e0", "type": "compound", "text": [ "tetraglyme" ], "offsets": [ [ 203, 213 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "8925" } ] }, { "id": "DS.d250.s1.e1", "type": "protein", "text": [ "fibrinogen" ], "offsets": [ [ 239, 249 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P22775" }, { "db_name": "UniProt", "db_id": "P81070" } ] } ]
[]
[]
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DS.d251
18497703
[ { "id": "DS.d251.s0", "type": "", "text": [ "Effects of inhibition of NOS, iNOS, and nNOS by N-nitro-L-arginine methyl ester (L-NAME), aminoguanidine, and 7-nitroindazole, respectively, were determined on the antigen-induced systemic hypotension and portal hypertension in conscious Sprague-Dawley rats sensitized with the ovalbumin antigen." ], "offsets": [ [ 0, 296 ] ] } ]
[ { "id": "DS.d251.s0.e0", "type": "protein", "text": [ "NOS" ], "offsets": [ [ 25, 28 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O54705" }, { "db_name": "UniProt", "db_id": "O61309" }, { "db_name": "UniProt", "db_id": "O61608" }, { "db_name": "UniProt", "db_id": "Q26240" }, { "db_name": "UniProt", "db_id": "Q28969" }, { "db_name": "UniProt", "db_id": "Q9I9M2" } ] }, { "id": "DS.d251.s0.e1", "type": "protein", "text": [ "iNOS" ], "offsets": [ [ 30, 34 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19114" }, { "db_name": "UniProt", "db_id": "O46660" }, { "db_name": "UniProt", "db_id": "O54705" }, { "db_name": "UniProt", "db_id": "O62699" }, { "db_name": "UniProt", "db_id": "P29477" }, { "db_name": "UniProt", "db_id": "P35228" }, { "db_name": "UniProt", "db_id": "P79290" }, { "db_name": "UniProt", "db_id": "Q06518" }, { "db_name": "UniProt", "db_id": "Q27995" }, { "db_name": "UniProt", "db_id": "Q28314" }, { "db_name": "UniProt", "db_id": "Q90703" }, { "db_name": "UniProt", "db_id": "Q92037" }, { "db_name": "UniProt", "db_id": "Q92091" } ] }, { "id": "DS.d251.s0.e2", "type": "protein", "text": [ "nNOS" ], "offsets": [ [ 40, 44 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19132" }, { "db_name": "UniProt", "db_id": "O61309" }, { "db_name": "UniProt", "db_id": "P29475" }, { "db_name": "UniProt", "db_id": "P29476" }, { "db_name": "UniProt", "db_id": "Q9Z0J4" } ] }, { "id": "DS.d251.s0.e3", "type": "compound", "text": [ "L-arginine methyl ester" ], "offsets": [ [ 56, 79 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "92932" }, { "db_name": "PubChem", "db_id": "550788" } ] }, { "id": "DS.d251.s0.e4", "type": "compound", "text": [ "aminoguanidine" ], "offsets": [ [ 90, 104 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2146" } ] }, { "id": "DS.d251.s0.e5", "type": "compound", "text": [ "7-nitroindazole" ], "offsets": [ [ 110, 125 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1893" } ] } ]
[]
[]
[]
DS.d252
18497707
[ { "id": "DS.d252.s0", "type": "", "text": [ "Differential gene expression of interleukin-1 receptor associated kinase-1 and interleukin-1 receptor associated kinase-M in peripheral blood mononuclear cells of young and aged rats following preconditioning with endotoxin." ], "offsets": [ [ 0, 224 ] ] }, { "id": "DS.d252.s1", "type": "", "text": [ "The IL-1 receptor-associated kinase 1 (IRAK-1) and IRAK-M are key signaling molecules in cellular responses to endotoxin initiated through the Toll-like receptors (TLRs)." ], "offsets": [ [ 225, 395 ] ] }, { "id": "DS.d252.s2", "type": "", "text": [ "The aim of this study was to evaluate the effect of age on the modulation of TLRs and IRAK-1 and IRAK-M in peripheral blood mononuclear cells (PBMCs) exposed in vitro to endotoxin under conditions that could induce endotoxin tolerance." ], "offsets": [ [ 396, 631 ] ] } ]
[ { "id": "DS.d252.s0.e0", "type": "protein", "text": [ "interleukin-1 receptor associated kinase-1" ], "offsets": [ [ 32, 74 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P51617" }, { "db_name": "UniProt", "db_id": "Q62406" } ] }, { "id": "DS.d252.s0.e1", "type": "compound", "text": [ "endotoxin" ], "offsets": [ [ 214, 223 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "44268108" } ] }, { "id": "DS.d252.s1.e0", "type": "protein", "text": [ "IRAK-1" ], "offsets": [ [ 264, 270 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P51617" }, { "db_name": "UniProt", "db_id": "Q62406" } ] }, { "id": "DS.d252.s1.e1", "type": "protein", "text": [ "IRAK-M" ], "offsets": [ [ 276, 282 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q8K4B2" }, { "db_name": "UniProt", "db_id": "Q9Y616" } ] }, { "id": "DS.d252.s1.e2", "type": "compound", "text": [ "endotoxin" ], "offsets": [ [ 336, 345 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "44268108" } ] }, { "id": "DS.d252.s1.e3", "type": "protein", "text": [ "TLRs" ], "offsets": [ [ 389, 393 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P23799" } ] }, { "id": "DS.d252.s2.e0", "type": "protein", "text": [ "TLRs" ], "offsets": [ [ 473, 477 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P23799" } ] }, { "id": "DS.d252.s2.e1", "type": "protein", "text": [ "IRAK-1" ], "offsets": [ [ 482, 488 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P51617" }, { "db_name": "UniProt", "db_id": "Q62406" } ] }, { "id": "DS.d252.s2.e2", "type": "protein", "text": [ "IRAK-M" ], "offsets": [ [ 493, 499 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q8K4B2" }, { "db_name": "UniProt", "db_id": "Q9Y616" } ] }, { "id": "DS.d252.s2.e3", "type": "compound", "text": [ "endotoxin" ], "offsets": [ [ 566, 575 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "44268108" } ] }, { "id": "DS.d252.s2.e4", "type": "compound", "text": [ "endotoxin" ], "offsets": [ [ 611, 620 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "44268108" } ] } ]
[]
[]
[ { "id": "DS.d252.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d252.s0.e1", "arg2_id": "DS.d252.s0.e0", "normalized": [] }, { "id": "DS.d252.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d252.s1.e2", "arg2_id": "DS.d252.s1.e1", "normalized": [] }, { "id": "DS.d252.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d252.s1.e2", "arg2_id": "DS.d252.s1.e3", "normalized": [] }, { "id": "DS.d252.s1.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d252.s1.e2", "arg2_id": "DS.d252.s1.e0", "normalized": [] } ]
DS.d253
18497709
[ { "id": "DS.d253.s0", "type": "", "text": [ "We also previously demonstrated that glutamine (GLN) significantly induced HO-1 in the lower intestinal tract." ], "offsets": [ [ 0, 110 ] ] }, { "id": "DS.d253.s1", "type": "", "text": [ "Glutamine treatment before HS (MAP of 30 mmHg for 60 min) significantly ameliorated HS-induced mucosal inflammation and apoptotic cell death in the ileum, as judged by significant decreases in gene expression of TNF-alpha, iNOS, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1, myeloperoxidase activity, the number of infiltrated neutrophils, DNA fragmentation by in situ oligo ligation assay, and activated caspase-3 expression, and by increases in gene expression of IL-10 and Bcl-2." ], "offsets": [ [ 111, 621 ] ] }, { "id": "DS.d253.s2", "type": "", "text": [ "Glutamine treatment may thus protect mucosal cells from HS-induced oxidative damage via the anti-inflammatory and antiapoptotic properties of HO-1." ], "offsets": [ [ 622, 769 ] ] } ]
[ { "id": "DS.d253.s0.e0", "type": "compound", "text": [ "glutamine" ], "offsets": [ [ 37, 46 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "738" }, { "db_name": "PubChem", "db_id": "5961" } ] }, { "id": "DS.d253.s0.e1", "type": "protein", "text": [ "HO-1" ], "offsets": [ [ 75, 79 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P06762" }, { "db_name": "UniProt", "db_id": "P09601" }, { "db_name": "UniProt", "db_id": "P14791" }, { "db_name": "UniProt", "db_id": "P14901" }, { "db_name": "UniProt", "db_id": "P32394" }, { "db_name": "UniProt", "db_id": "Q5E9F2" } ] }, { "id": "DS.d253.s1.e0", "type": "compound", "text": [ "Glutamine" ], "offsets": [ [ 111, 120 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "738" }, { "db_name": "PubChem", "db_id": "5961" } ] }, { "id": "DS.d253.s1.e1", "type": "compound", "text": [ "HS" ], "offsets": [ [ 138, 140 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5047209" }, { "db_name": "PubChem", "db_id": "46173182" } ] }, { "id": "DS.d253.s1.e2", "type": "compound", "text": [ "HS" ], "offsets": [ [ 195, 197 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5047209" }, { "db_name": "PubChem", "db_id": "46173182" } ] }, { "id": "DS.d253.s1.e3", "type": "protein", "text": [ "TNF-alpha" ], "offsets": [ [ 323, 332 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35734" }, { "db_name": "UniProt", "db_id": "O77510" }, { "db_name": "UniProt", "db_id": "O77764" }, { "db_name": "UniProt", "db_id": "P01375" }, { "db_name": "UniProt", "db_id": "P04924" }, { "db_name": "UniProt", "db_id": "P06804" }, { "db_name": "UniProt", "db_id": "P13296" }, { "db_name": "UniProt", "db_id": "P16599" }, { "db_name": "UniProt", "db_id": "P19101" }, { "db_name": "UniProt", "db_id": "P23383" }, { "db_name": "UniProt", "db_id": "P23563" }, { "db_name": "UniProt", "db_id": "P29553" }, { "db_name": "UniProt", "db_id": "P33620" }, { "db_name": "UniProt", "db_id": "P36939" }, { "db_name": "UniProt", "db_id": "P48094" }, { "db_name": "UniProt", "db_id": "P51435" }, { "db_name": "UniProt", "db_id": "P51742" }, { "db_name": "UniProt", "db_id": "P51743" }, { "db_name": "UniProt", "db_id": "P59684" }, { "db_name": "UniProt", "db_id": "P59693" }, { "db_name": "UniProt", "db_id": "P59694" }, { "db_name": "UniProt", "db_id": "P59695" }, { "db_name": "UniProt", "db_id": "P79337" }, { "db_name": "UniProt", "db_id": "P79374" }, { "db_name": "UniProt", "db_id": "Q06599" }, { "db_name": "UniProt", "db_id": "Q19LH4" }, { "db_name": "UniProt", "db_id": "Q1G1A2" }, { "db_name": "UniProt", "db_id": "Q1WM27" }, { "db_name": "UniProt", "db_id": "Q2MH05" }, { "db_name": "UniProt", "db_id": "Q539C2" }, { "db_name": "UniProt", "db_id": "Q75N23" }, { "db_name": "UniProt", "db_id": "Q8HZD9" }, { "db_name": "UniProt", "db_id": "Q8JFG3" }, { "db_name": "UniProt", "db_id": "Q8MKG8" }, { "db_name": "UniProt", "db_id": "Q8WNR1" }, { "db_name": "UniProt", "db_id": "Q9BEA1" } ] }, { "id": "DS.d253.s1.e4", "type": "protein", "text": [ "iNOS" ], "offsets": [ [ 334, 338 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19114" }, { "db_name": "UniProt", "db_id": "O46660" }, { "db_name": "UniProt", "db_id": "O54705" }, { "db_name": "UniProt", "db_id": "O62699" }, { "db_name": "UniProt", "db_id": "P29477" }, { "db_name": "UniProt", "db_id": "P35228" }, { "db_name": "UniProt", "db_id": "P79290" }, { "db_name": "UniProt", "db_id": "Q06518" }, { "db_name": "UniProt", "db_id": "Q27995" }, { "db_name": "UniProt", "db_id": "Q28314" }, { "db_name": "UniProt", "db_id": "Q90703" }, { "db_name": "UniProt", "db_id": "Q92037" }, { "db_name": "UniProt", "db_id": "Q92091" } ] }, { "id": "DS.d253.s1.e5", "type": "protein", "text": [ "IL-10" ], "offsets": [ [ 605, 610 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O46673" }, { "db_name": "UniProt", "db_id": "O97798" }, { "db_name": "UniProt", "db_id": "P18893" }, { "db_name": "UniProt", "db_id": "P22301" }, { "db_name": "UniProt", "db_id": "P29456" }, { "db_name": "UniProt", "db_id": "P43480" }, { "db_name": "UniProt", "db_id": "P46651" }, { "db_name": "UniProt", "db_id": "P47965" }, { "db_name": "UniProt", "db_id": "P48411" }, { "db_name": "UniProt", "db_id": "P51496" }, { "db_name": "UniProt", "db_id": "P51497" }, { "db_name": "UniProt", "db_id": "P51746" }, { "db_name": "UniProt", "db_id": "P55029" }, { "db_name": "UniProt", "db_id": "P79338" }, { "db_name": "UniProt", "db_id": "Q0Z972" }, { "db_name": "UniProt", "db_id": "Q25BC1" }, { "db_name": "UniProt", "db_id": "Q28374" }, { "db_name": "UniProt", "db_id": "Q29055" }, { "db_name": "UniProt", "db_id": "Q29408" }, { "db_name": "UniProt", "db_id": "Q2PE73" }, { "db_name": "UniProt", "db_id": "Q5Q0V6" }, { "db_name": "UniProt", "db_id": "Q865X4" }, { "db_name": "UniProt", "db_id": "Q8MKG9" }, { "db_name": "UniProt", "db_id": "Q9JHK7" }, { "db_name": "UniProt", "db_id": "Q9TSJ4" }, { "db_name": "UniProt", "db_id": "Q9Z1Y5" } ] }, { "id": "DS.d253.s1.e6", "type": "protein", "text": [ "Bcl-2" ], "offsets": [ [ 615, 620 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10417" }, { "db_name": "UniProt", "db_id": "P49950" } ] }, { "id": "DS.d253.s2.e0", "type": "compound", "text": [ "Glutamine" ], "offsets": [ [ 622, 631 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "738" }, { "db_name": "PubChem", "db_id": "5961" } ] }, { "id": "DS.d253.s2.e1", "type": "protein", "text": [ "HO-1" ], "offsets": [ [ 764, 768 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P06762" }, { "db_name": "UniProt", "db_id": "P09601" }, { "db_name": "UniProt", "db_id": "P14791" }, { "db_name": "UniProt", "db_id": "P14901" }, { "db_name": "UniProt", "db_id": "P32394" }, { "db_name": "UniProt", "db_id": "Q5E9F2" } ] } ]
[]
[]
[ { "id": "DS.d253.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d253.s1.e0", "arg2_id": "DS.d253.s1.e5", "normalized": [] }, { "id": "DS.d253.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d253.s1.e0", "arg2_id": "DS.d253.s1.e3", "normalized": [] }, { "id": "DS.d253.s1.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d253.s1.e0", "arg2_id": "DS.d253.s1.e4", "normalized": [] }, { "id": "DS.d253.s1.i5", "type": "compound-protein-interaction", "arg1_id": "DS.d253.s1.e0", "arg2_id": "DS.d253.s1.e6", "normalized": [] }, { "id": "DS.d253.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d253.s2.e0", "arg2_id": "DS.d253.s2.e1", "normalized": [] } ]
DS.d254
18498083
[ { "id": "DS.d254.s0", "type": "", "text": [ "In this work, we identified a high affinity and potency metallocene-containing triazole peptide conjugate that suppresses the interactions of HIV-1 envelope gp120 at both its CD4 and co-receptor binding sites." ], "offsets": [ [ 0, 209 ] ] }, { "id": "DS.d254.s1", "type": "", "text": [ "Surface plasmon resonance interaction analysis revealed that, compared to a previously reported phenyl-containing triazole conjugate HNG-105 (105), peptide 156 had a higher direct binding affinity for several subtypes of HIV-1 gp120 due mainly to the decreased dissociation rate of the conjugate-gp120 complex." ], "offsets": [ [ 210, 520 ] ] }, { "id": "DS.d254.s2", "type": "", "text": [ "The ferrocene triazole conjugate bound to gp120 of both clade A (92UG037-08) and clade B (YU-2 and SF162) virus subtypes with nanomolar KD in direct binding and inhibited the binding of gp120 to soluble CD4 and to antibodies that bind to HIV-1YU-2 gp120 at both the CD4 binding site and CD4-induced binding sites." ], "offsets": [ [ 521, 834 ] ] } ]
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[]
[]
[ { "id": "DS.d254.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d254.s0.e0", "arg2_id": "DS.d254.s0.e2", "normalized": [] }, { "id": "DS.d254.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d254.s0.e0", "arg2_id": "DS.d254.s0.e1", "normalized": [] }, { "id": "DS.d254.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d254.s1.e1", "arg2_id": "DS.d254.s1.e2", "normalized": [] }, { "id": "DS.d254.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d254.s1.e0", "arg2_id": "DS.d254.s1.e2", "normalized": [] }, { "id": "DS.d254.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d254.s2.e0", "arg2_id": "DS.d254.s2.e3", "normalized": [] }, { "id": "DS.d254.s2.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d254.s2.e0", "arg2_id": "DS.d254.s2.e1", "normalized": [] } ]
DS.d255
18498357
[ { "id": "DS.d255.s0", "type": "", "text": [ "Screening of risk factors for thromboembolism revealed that all patients carried a methylenetetrahydrofolate reductase 677C-->T (MTHFR) mutation in a gene involved in folate metabolism, and either borderline or elevated homocysteine levels." ], "offsets": [ [ 0, 243 ] ] } ]
[ { "id": "DS.d255.s0.e0", "type": "protein", "text": [ "methylenetetrahydrofolate reductase" ], "offsets": [ [ 83, 118 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P42898" }, { "db_name": "UniProt", "db_id": "Q5I598" }, { "db_name": "UniProt", "db_id": "Q60HE5" }, { "db_name": "UniProt", "db_id": "Q9WU20" } ] }, { "id": "DS.d255.s0.e1", "type": "protein", "text": [ "MTHFR" ], "offsets": [ [ 132, 137 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P42898" }, { "db_name": "UniProt", "db_id": "Q5I598" }, { "db_name": "UniProt", "db_id": "Q60HE5" } ] }, { "id": "DS.d255.s0.e2", "type": "compound", "text": [ "homocysteine" ], "offsets": [ [ 223, 235 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "778" } ] } ]
[]
[]
[]
DS.d256
18498673
[ { "id": "DS.d256.s0", "type": "", "text": [ "Circulating leptin was negatively correlated with mRNA expression of adiponectin, LEPR and LPL, whereas thyroxine was positively correlated with levels of PPARGC1A." ], "offsets": [ [ 0, 164 ] ] } ]
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[]
[]
[ { "id": "DS.d256.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d256.s0.e3", "arg2_id": "DS.d256.s0.e4", "normalized": [] } ]
DS.d257
18500430
[ { "id": "DS.d257.s0", "type": "", "text": [ "In the absence of exogenous Ca(2+) and Mg(2+) and in the presence of EGTA, which favours the release of endogenous Ca(2+), the polyamine spermine is able to stimulate the activity of pyruvate dehydrogenase complex (PDC) of energized rat liver mitochondria (RLM)." ], "offsets": [ [ 0, 262 ] ] }, { "id": "DS.d257.s1", "type": "", "text": [ "At concentrations higher than 0.5 mM, spermine still stimulates PDC, when compared with the control, but shows a slight dose-dependent decrease." ], "offsets": [ [ 263, 407 ] ] }, { "id": "DS.d257.s2", "type": "", "text": [ "Changes in PDC stimulation are very close to the phosphorylation level of the E(1alpha) subunit of PDC, which regulates the activity of the complex, but it is also the target of spermine." ], "offsets": [ [ 408, 595 ] ] }, { "id": "DS.d257.s3", "type": "", "text": [ "These results provide the first evidence that, when transported in RLM, spermine can interact in various ways with PDC, showing dose-dependent behaviour." ], "offsets": [ [ 596, 749 ] ] } ]
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"P20941" }, { "db_name": "UniProt", "db_id": "P28516" }, { "db_name": "UniProt", "db_id": "P34734" }, { "db_name": "UniProt", "db_id": "P41686" }, { "db_name": "UniProt", "db_id": "P51845" }, { "db_name": "UniProt", "db_id": "P51846" }, { "db_name": "UniProt", "db_id": "P51847" }, { "db_name": "UniProt", "db_id": "P51848" }, { "db_name": "UniProt", "db_id": "P51849" }, { "db_name": "UniProt", "db_id": "P51850" }, { "db_name": "UniProt", "db_id": "P51851" }, { "db_name": "UniProt", "db_id": "Q05326" }, { "db_name": "UniProt", "db_id": "Q05327" }, { "db_name": "UniProt", "db_id": "Q6FJA3" }, { "db_name": "UniProt", "db_id": "Q9XS39" } ] }, { "id": "DS.d257.s2.e0", "type": "protein", "text": [ "PDC" ], "offsets": [ [ 419, 422 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O77560" }, { "db_name": "UniProt", "db_id": "P06672" }, { "db_name": "UniProt", "db_id": "P19632" }, { "db_name": "UniProt", "db_id": "P20941" }, { "db_name": "UniProt", "db_id": "P28516" }, { "db_name": "UniProt", "db_id": "P34734" }, { "db_name": "UniProt", "db_id": "P41686" }, { "db_name": "UniProt", "db_id": "P51845" }, { "db_name": "UniProt", "db_id": "P51846" }, { "db_name": "UniProt", "db_id": "P51847" }, { "db_name": "UniProt", "db_id": "P51848" }, { "db_name": "UniProt", "db_id": "P51849" }, { "db_name": "UniProt", "db_id": "P51850" }, { "db_name": "UniProt", "db_id": "P51851" }, { "db_name": "UniProt", "db_id": "Q05326" }, { "db_name": "UniProt", "db_id": "Q05327" }, { "db_name": "UniProt", "db_id": "Q6FJA3" }, { "db_name": "UniProt", "db_id": "Q9XS39" } ] }, { "id": "DS.d257.s2.e1", "type": "protein", "text": [ "PDC" ], "offsets": [ [ 507, 510 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O77560" }, { "db_name": "UniProt", "db_id": "P06672" }, { "db_name": "UniProt", "db_id": "P19632" }, { "db_name": "UniProt", "db_id": "P20941" }, { "db_name": "UniProt", "db_id": "P28516" }, { "db_name": "UniProt", "db_id": "P34734" }, { "db_name": "UniProt", "db_id": "P41686" }, { "db_name": "UniProt", "db_id": "P51845" }, { "db_name": "UniProt", "db_id": "P51846" }, { "db_name": "UniProt", "db_id": "P51847" }, { "db_name": "UniProt", "db_id": "P51848" }, { "db_name": "UniProt", "db_id": "P51849" }, { "db_name": "UniProt", "db_id": "P51850" }, { "db_name": "UniProt", "db_id": "P51851" }, { "db_name": "UniProt", "db_id": "Q05326" }, { "db_name": "UniProt", "db_id": "Q05327" }, { "db_name": "UniProt", "db_id": "Q6FJA3" }, { "db_name": "UniProt", "db_id": "Q9XS39" } ] }, { "id": "DS.d257.s2.e2", "type": "compound", "text": [ "spermine" ], "offsets": [ [ 586, 594 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1103" } ] }, { "id": "DS.d257.s3.e0", "type": "compound", "text": [ "spermine" ], "offsets": [ [ 668, 676 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1103" } ] }, { "id": "DS.d257.s3.e1", "type": "protein", "text": [ "PDC" ], "offsets": [ [ 711, 714 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O77560" }, { "db_name": "UniProt", "db_id": "P06672" }, { "db_name": "UniProt", "db_id": "P19632" }, { "db_name": "UniProt", "db_id": "P20941" }, { "db_name": "UniProt", "db_id": "P28516" }, { "db_name": "UniProt", "db_id": "P34734" }, { "db_name": "UniProt", "db_id": "P41686" }, { "db_name": "UniProt", "db_id": "P51845" }, { "db_name": "UniProt", "db_id": "P51846" }, { "db_name": "UniProt", "db_id": "P51847" }, { "db_name": "UniProt", "db_id": "P51848" }, { "db_name": "UniProt", "db_id": "P51849" }, { "db_name": "UniProt", "db_id": "P51850" }, { "db_name": "UniProt", "db_id": "P51851" }, { "db_name": "UniProt", "db_id": "Q05326" }, { "db_name": "UniProt", "db_id": "Q05327" }, { "db_name": "UniProt", "db_id": "Q6FJA3" }, { "db_name": "UniProt", "db_id": "Q9XS39" } ] } ]
[]
[]
[ { "id": "DS.d257.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d257.s0.e3", "arg2_id": "DS.d257.s0.e4", "normalized": [] }, { "id": "DS.d257.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d257.s1.e0", "arg2_id": "DS.d257.s1.e1", "normalized": [] }, { "id": "DS.d257.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d257.s2.e2", "arg2_id": "DS.d257.s2.e0", "normalized": [] }, { "id": "DS.d257.s3.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d257.s3.e0", "arg2_id": "DS.d257.s3.e1", "normalized": [] } ]
DS.d258
18500522
[ { "id": "DS.d258.s0", "type": "", "text": [ "This study assessed relationships between hNT levels and fludarabine uptake and cytotoxicity in cultures of human renal proximal tubule cells (hRPTCs) that produce multiple transporter types." ], "offsets": [ [ 0, 191 ] ] } ]
[ { "id": "DS.d258.s0.e0", "type": "protein", "text": [ "hNT" ], "offsets": [ [ 42, 45 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9P121" } ] }, { "id": "DS.d258.s0.e1", "type": "compound", "text": [ "fludarabine" ], "offsets": [ [ 57, 68 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "657237" } ] } ]
[]
[]
[]
DS.d259
18502597
[ { "id": "DS.d259.s0", "type": "", "text": [ "Multiple metabolic and neuroendocrine mechanisms are responsible for the CR-mediated anti-inflammatory effects, including reduced adiposity and secretion of pro-inflammatory adipokines, enhanced glucocorticoid production, reduced plasma glucose and advanced glycation end-product concentrations, increased parasympathetic tone, and increased ghrelin production." ], "offsets": [ [ 0, 361 ] ] } ]
[ { "id": "DS.d259.s0.e0", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 237, 244 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d259.s0.e1", "type": "protein", "text": [ "ghrelin" ], "offsets": [ [ 342, 349 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q6BEG6" }, { "db_name": "UniProt", "db_id": "Q6BEG7" }, { "db_name": "UniProt", "db_id": "Q9BDJ6" }, { "db_name": "UniProt", "db_id": "Q9BEF8" }, { "db_name": "UniProt", "db_id": "Q9EQX0" }, { "db_name": "UniProt", "db_id": "Q9GKY5" }, { "db_name": "UniProt", "db_id": "Q9QYH7" }, { "db_name": "UniProt", "db_id": "Q9UBU3" } ] } ]
[]
[]
[]
DS.d260
18503570
[ { "id": "DS.d260.s0", "type": "", "text": [ "From the known regulatory mechanisms of Arc expression, HFD reduced N-methyl-D-aspartate receptor (NMDAR) activity, as seen by decreases in tyrosine phosphorylation of NMDAR2A and levels of NMDAR1." ], "offsets": [ [ 0, 197 ] ] }, { "id": "DS.d260.s1", "type": "", "text": [ "Additionally, we demonstrated that 27-hydroxycholesterol, a cholesterol metabolite that enters the brain from the blood, decreases Arc levels as well as NMDAR and Src kinase activities in rat primary hippocampal neurons." ], "offsets": [ [ 198, 418 ] ] } ]
[ { "id": "DS.d260.s0.e0", "type": "protein", "text": [ "N-methyl-D-aspartate receptor" ], "offsets": [ [ 68, 97 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P35439" }, { "db_name": "UniProt", "db_id": "Q9R1M7" } ] }, { "id": "DS.d260.s0.e1", "type": "compound", "text": [ "tyrosine" ], "offsets": [ [ 140, 148 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1153" }, { "db_name": "PubChem", "db_id": "6057" }, { "db_name": "PubChem", "db_id": "5460803" } ] }, { "id": "DS.d260.s0.e2", "type": "protein", "text": [ "NMDAR2A" ], "offsets": [ [ 168, 175 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P35436" }, { "db_name": "UniProt", "db_id": "Q00959" }, { "db_name": "UniProt", "db_id": "Q12879" }, { "db_name": "UniProt", "db_id": "Q5IS45" } ] }, { "id": "DS.d260.s0.e3", "type": "protein", "text": [ "NMDAR1" ], "offsets": [ [ 190, 196 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q05586" }, { "db_name": "UniProt", "db_id": "Q5R1P0" } ] }, { "id": "DS.d260.s1.e0", "type": "compound", "text": [ "27-hydroxycholesterol" ], "offsets": [ [ 233, 254 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "99470" }, { "db_name": "PubChem", "db_id": "123976" }, { "db_name": "PubChem", "db_id": "50990021" } ] }, { "id": "DS.d260.s1.e1", "type": "compound", "text": [ "cholesterol" ], "offsets": [ [ 243, 254 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "304" }, { "db_name": "PubChem", "db_id": "5997" }, { "db_name": "PubChem", "db_id": "6432564" }, { "db_name": "PubChem", "db_id": "11025495" } ] }, { "id": "DS.d260.s1.e2", "type": "protein", "text": [ "Src" ], "offsets": [ [ 361, 364 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05480" }, { "db_name": "UniProt", "db_id": "Q9WUD9" } ] } ]
[]
[]
[ { "id": "DS.d260.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d260.s0.e1", "arg2_id": "DS.d260.s0.e2", "normalized": [] }, { "id": "DS.d260.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d260.s0.e1", "arg2_id": "DS.d260.s0.e0", "normalized": [] }, { "id": "DS.d260.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d260.s1.e1", "arg2_id": "DS.d260.s1.e2", "normalized": [] }, { "id": "DS.d260.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d260.s1.e0", "arg2_id": "DS.d260.s1.e2", "normalized": [] } ]
DS.d261
18505747
[ { "id": "DS.d261.s0", "type": "", "text": [ "Cyclooxygenase-2, an inducible enzyme important in inflammation, catalyzes the production of prostanoids from arachidonic acid." ], "offsets": [ [ 0, 127 ] ] } ]
[ { "id": "DS.d261.s0.e0", "type": "protein", "text": [ "Cyclooxygenase-2" ], "offsets": [ [ 0, 16 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02768" }, { "db_name": "UniProt", "db_id": "O19183" }, { "db_name": "UniProt", "db_id": "O62698" }, { "db_name": "UniProt", "db_id": "O62725" }, { "db_name": "UniProt", "db_id": "P27607" }, { "db_name": "UniProt", "db_id": "P35354" }, { "db_name": "UniProt", "db_id": "P35355" }, { "db_name": "UniProt", "db_id": "P70682" }, { "db_name": "UniProt", "db_id": "P79208" }, { "db_name": "UniProt", "db_id": "Q05769" } ] }, { "id": "DS.d261.s0.e1", "type": "compound", "text": [ "arachidonic acid" ], "offsets": [ [ 110, 126 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "444899" } ] } ]
[]
[]
[ { "id": "DS.d261.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d261.s0.e1", "arg2_id": "DS.d261.s0.e0", "normalized": [] } ]
DS.d262
18506596
[ { "id": "DS.d262.s0", "type": "", "text": [ "cDNA probes have been developed for subsequent use in monitoring the cadmium exposure of the clam Ruditapes decussatus and the cockle Cerastoderma glaucum using metallothionein (MT) gene expression in different tissues of these species." ], "offsets": [ [ 0, 236 ] ] } ]
[ { "id": "DS.d262.s0.e0", "type": "compound", "text": [ "cadmium" ], "offsets": [ [ 69, 76 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23973" } ] }, { "id": "DS.d262.s0.e1", "type": "protein", "text": [ "metallothionein" ], "offsets": [ [ 161, 176 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02033" }, { "db_name": "UniProt", "db_id": "O13257" }, { "db_name": "UniProt", "db_id": "O18842" }, { "db_name": "UniProt", "db_id": "O42152" }, { "db_name": "UniProt", "db_id": "O93571" }, { "db_name": "UniProt", "db_id": "P02807" }, { "db_name": "UniProt", "db_id": "P04358" }, { "db_name": "UniProt", "db_id": "P07216" }, { "db_name": "UniProt", "db_id": "P08002" }, { "db_name": "UniProt", "db_id": "P23038" }, { "db_name": "UniProt", "db_id": "P25127" }, { "db_name": "UniProt", "db_id": "P25128" }, { "db_name": "UniProt", "db_id": "P30331" }, { "db_name": "UniProt", "db_id": "P30565" }, { "db_name": "UniProt", "db_id": "P51902" }, { "db_name": "UniProt", "db_id": "P52723" }, { "db_name": "UniProt", "db_id": "P52725" }, { "db_name": "UniProt", "db_id": "P52726" }, { "db_name": "UniProt", "db_id": "P52728" }, { "db_name": "UniProt", "db_id": "P55945" }, { "db_name": "UniProt", "db_id": "P55946" }, { "db_name": "UniProt", "db_id": "P55948" }, { "db_name": "UniProt", "db_id": "P55951" }, { "db_name": "UniProt", "db_id": "P55952" }, { "db_name": "UniProt", "db_id": "P55953" }, { "db_name": "UniProt", "db_id": "P68494" }, { "db_name": "UniProt", "db_id": "P68495" }, { "db_name": "UniProt", "db_id": "P68497" }, { "db_name": "UniProt", "db_id": "P68498" }, { "db_name": "UniProt", "db_id": "P68499" }, { "db_name": "UniProt", "db_id": "P80367" }, { "db_name": "UniProt", "db_id": "P80593" }, { "db_name": "UniProt", "db_id": "P84865" }, { "db_name": "UniProt", "db_id": "Q05890" }, { "db_name": "UniProt", "db_id": "Q6J1T3" }, { "db_name": "UniProt", "db_id": "Q6S4N8" }, { "db_name": "UniProt", "db_id": "Q6XUW5" }, { "db_name": "UniProt", "db_id": "Q708T3" }, { "db_name": "UniProt", "db_id": "Q7ZZP9" }, { "db_name": "UniProt", "db_id": "Q800D3" }, { "db_name": "UniProt", "db_id": "Q8UVY1" }, { "db_name": "UniProt", "db_id": "Q94550" }, { "db_name": "UniProt", "db_id": "Q9IB50" }, { "db_name": "UniProt", "db_id": "Q9U568" } ] } ]
[]
[]
[]
DS.d263
18506630
[ { "id": "DS.d263.s0", "type": "", "text": [ "Purified lignin peroxidase was able to oxidize a variety of substrates including Mn2+, tryptophan, mimosine, L-Dopa, hydroquinone, xylidine, n-propanol, veratryl alcohol, and ten textile dyes of various groups indicating as a versatile peroxidase." ], "offsets": [ [ 0, 247 ] ] }, { "id": "DS.d263.s1", "type": "", "text": [ "Tryptophan stabilizes the lignin peroxidase activity during decolorization of dyes." ], "offsets": [ [ 248, 331 ] ] } ]
[ { "id": "DS.d263.s0.e0", "type": "protein", "text": [ "lignin peroxidase" ], "offsets": [ [ 9, 26 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P06181" }, { "db_name": "UniProt", "db_id": "P11542" }, { "db_name": "UniProt", "db_id": "P11543" }, { "db_name": "UniProt", "db_id": "P20010" }, { "db_name": "UniProt", "db_id": "P20011" }, { "db_name": "UniProt", "db_id": "P20012" }, { "db_name": "UniProt", "db_id": "P20013" }, { "db_name": "UniProt", "db_id": "P21764" }, { "db_name": "UniProt", "db_id": "P31837" }, { "db_name": "UniProt", "db_id": "P31838" }, { "db_name": "UniProt", "db_id": "P49012" }, { "db_name": "UniProt", "db_id": "P50622" } ] }, { "id": "DS.d263.s0.e1", "type": "compound", "text": [ "Mn2" ], "offsets": [ [ 81, 84 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "27854" } ] }, { "id": "DS.d263.s0.e2", "type": "compound", "text": [ "tryptophan" ], "offsets": [ [ 87, 97 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1148" }, { "db_name": "PubChem", "db_id": "6305" }, { "db_name": "PubChem", "db_id": "9060" }, { "db_name": "PubChem", "db_id": "5460840" } ] }, { "id": "DS.d263.s0.e3", "type": "compound", "text": [ "mimosine" ], "offsets": [ [ 99, 107 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3862" } ] }, { "id": "DS.d263.s0.e4", "type": "compound", "text": [ "L-Dopa" ], "offsets": [ [ 109, 115 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6047" } ] }, { "id": "DS.d263.s0.e5", "type": "compound", "text": [ "hydroquinone" ], "offsets": [ [ 117, 129 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "785" } ] }, { "id": "DS.d263.s0.e6", "type": "compound", "text": [ "n-propanol" ], "offsets": [ [ 141, 151 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1031" } ] }, { "id": "DS.d263.s0.e7", "type": "compound", "text": [ "veratryl alcohol" ], "offsets": [ [ 153, 169 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "7118" } ] }, { "id": "DS.d263.s1.e0", "type": "compound", "text": [ "Tryptophan" ], "offsets": [ [ 248, 258 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1148" }, { "db_name": "PubChem", "db_id": "6305" }, { "db_name": "PubChem", "db_id": "9060" }, { "db_name": "PubChem", "db_id": "5460840" } ] }, { "id": "DS.d263.s1.e1", "type": "protein", "text": [ "lignin peroxidase" ], "offsets": [ [ 274, 291 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P06181" }, { "db_name": "UniProt", "db_id": "P11542" }, { "db_name": "UniProt", "db_id": "P11543" }, { "db_name": "UniProt", "db_id": "P20010" }, { "db_name": "UniProt", "db_id": "P20011" }, { "db_name": "UniProt", "db_id": "P20012" }, { "db_name": "UniProt", "db_id": "P20013" }, { "db_name": "UniProt", "db_id": "P21764" }, { "db_name": "UniProt", "db_id": "P31837" }, { "db_name": "UniProt", "db_id": "P31838" }, { "db_name": "UniProt", "db_id": "P49012" }, { "db_name": "UniProt", "db_id": "P50622" } ] } ]
[]
[]
[ { "id": "DS.d263.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d263.s0.e6", "arg2_id": "DS.d263.s0.e0", "normalized": [] }, { "id": "DS.d263.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d263.s0.e5", "arg2_id": "DS.d263.s0.e0", "normalized": [] }, { "id": "DS.d263.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d263.s0.e1", "arg2_id": "DS.d263.s0.e0", "normalized": [] }, { "id": "DS.d263.s0.i7", "type": "compound-protein-interaction", "arg1_id": "DS.d263.s0.e3", "arg2_id": "DS.d263.s0.e0", "normalized": [] }, { "id": "DS.d263.s0.i9", "type": "compound-protein-interaction", "arg1_id": "DS.d263.s0.e4", "arg2_id": "DS.d263.s0.e0", "normalized": [] }, { "id": "DS.d263.s0.i10", "type": "compound-protein-interaction", "arg1_id": "DS.d263.s0.e7", "arg2_id": "DS.d263.s0.e0", "normalized": [] }, { "id": "DS.d263.s0.i13", "type": "compound-protein-interaction", "arg1_id": "DS.d263.s0.e2", "arg2_id": "DS.d263.s0.e0", "normalized": [] }, { "id": "DS.d263.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d263.s1.e0", "arg2_id": "DS.d263.s1.e1", "normalized": [] } ]
DS.d264
18506631
[ { "id": "DS.d264.s0", "type": "", "text": [ "To achieve enzymatic production of calcium-stearate at unfavorable conditions, i.e., pH 10 and 60 degrees C, suitable lipase was selected and reaction conditions were optimized using calcium hydroxide and hydrogenated beef tallow as substrates." ], "offsets": [ [ 0, 244 ] ] }, { "id": "DS.d264.s1", "type": "", "text": [ "Under optimum conditions, 95% of beef tallow, in 2.5 h, was converted into calcium-stearate by using commercial lipase SDL 451." ], "offsets": [ [ 245, 372 ] ] } ]
[ { "id": "DS.d264.s0.e0", "type": "compound", "text": [ "calcium-stearate" ], "offsets": [ [ 35, 51 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5281" } ] }, { "id": "DS.d264.s0.e1", "type": "protein", "text": [ "lipase" ], "offsets": [ [ 118, 124 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q7M4U7" } ] }, { "id": "DS.d264.s0.e2", "type": "compound", "text": [ "hydroxide" ], "offsets": [ [ 191, 200 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "961" } ] }, { "id": "DS.d264.s1.e0", "type": "compound", "text": [ "calcium-stearate" ], "offsets": [ [ 320, 336 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5281" } ] }, { "id": "DS.d264.s1.e1", "type": "protein", "text": [ "lipase" ], "offsets": [ [ 357, 363 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q7M4U7" } ] } ]
[]
[]
[ { "id": "DS.d264.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d264.s0.e2", "arg2_id": "DS.d264.s0.e1", "normalized": [] }, { "id": "DS.d264.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d264.s0.e0", "arg2_id": "DS.d264.s0.e1", "normalized": [] }, { "id": "DS.d264.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d264.s1.e0", "arg2_id": "DS.d264.s1.e1", "normalized": [] } ]
DS.d265
18506760
[ { "id": "DS.d265.s0", "type": "", "text": [ "Celecoxib could selectively inhibited COX-2 expression and PGE2 production." ], "offsets": [ [ 0, 75 ] ] }, { "id": "DS.d265.s1", "type": "", "text": [ "Celecoxib also inhibited p(473Ser) Akt, raf and p53 expression, and induced apoptosis by release of cytochrome c and activation of caspase 9, 3, and 6, which were more remarkably in HBx positive cells than in control cells." ], "offsets": [ [ 76, 299 ] ] } ]
[ { "id": "DS.d265.s0.e0", "type": "compound", "text": [ "Celecoxib" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2662" } ] }, { "id": "DS.d265.s0.e1", "type": "protein", "text": [ "COX-2" ], "offsets": [ [ 38, 43 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02768" }, { "db_name": "UniProt", "db_id": "O19183" }, { "db_name": "UniProt", "db_id": "O62698" }, { "db_name": "UniProt", "db_id": "O62725" }, { "db_name": "UniProt", "db_id": "P27607" }, { "db_name": "UniProt", "db_id": "P35354" }, { "db_name": "UniProt", "db_id": "P35355" }, { "db_name": "UniProt", "db_id": "P70682" }, { "db_name": "UniProt", "db_id": "P79208" }, { "db_name": "UniProt", "db_id": "Q05769" } ] }, { "id": "DS.d265.s0.e2", "type": "compound", "text": [ "PGE2" ], "offsets": [ [ 59, 63 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280360" } ] }, { "id": "DS.d265.s1.e0", "type": "compound", "text": [ "Celecoxib" ], "offsets": [ [ 76, 85 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2662" } ] }, { "id": "DS.d265.s1.e1", "type": "protein", "text": [ "Akt" ], "offsets": [ [ 111, 114 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P31750" }, { "db_name": "UniProt", "db_id": "Q8INB9" } ] }, { "id": "DS.d265.s1.e2", "type": "protein", "text": [ "raf" ], "offsets": [ [ 116, 119 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P09560" }, { "db_name": "UniProt", "db_id": "P11345" }, { "db_name": "UniProt", "db_id": "Q80VX4" }, { "db_name": "UniProt", "db_id": "Q8C0C0" } ] }, { "id": "DS.d265.s1.e3", "type": "protein", "text": [ "p53" ], "offsets": [ [ 124, 127 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O09185" }, { "db_name": "UniProt", "db_id": "O12946" }, { "db_name": "UniProt", "db_id": "O57538" }, { "db_name": "UniProt", "db_id": "O93379" }, { "db_name": "UniProt", "db_id": "P02340" }, { "db_name": "UniProt", "db_id": "P04637" }, { "db_name": "UniProt", "db_id": "P10361" }, { "db_name": "UniProt", "db_id": "P19558" }, { "db_name": "UniProt", "db_id": "P19559" }, { "db_name": "UniProt", "db_id": "P56423" }, { "db_name": "UniProt", "db_id": "P56424" }, { "db_name": "UniProt", "db_id": "P61260" }, { "db_name": "UniProt", "db_id": "P79820" }, { "db_name": "UniProt", "db_id": "P79892" }, { "db_name": "UniProt", "db_id": "Q29537" }, { "db_name": "UniProt", "db_id": "Q42578" }, { "db_name": "UniProt", "db_id": "Q8SPZ3" }, { "db_name": "UniProt", "db_id": "Q92143" }, { "db_name": "UniProt", "db_id": "Q9TTA1" }, { "db_name": "UniProt", "db_id": "Q9TUB2" }, { "db_name": "UniProt", "db_id": "Q9W678" }, { "db_name": "UniProt", "db_id": "Q9W679" } ] }, { "id": "DS.d265.s1.e4", "type": "protein", "text": [ "cytochrome c" ], "offsets": [ [ 176, 188 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O07091" }, { "db_name": "UniProt", "db_id": "O13393" }, { "db_name": "UniProt", "db_id": "O22642" }, { "db_name": "UniProt", "db_id": "O93863" }, { "db_name": "UniProt", "db_id": "P00002" }, { "db_name": 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"UniProt", "db_id": "Q96VP3" } ] } ]
[]
[]
[ { "id": "DS.d265.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d265.s0.e0", "arg2_id": "DS.d265.s0.e1", "normalized": [] }, { "id": "DS.d265.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d265.s1.e0", "arg2_id": "DS.d265.s1.e4", "normalized": [] }, { "id": "DS.d265.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d265.s1.e0", "arg2_id": "DS.d265.s1.e1", "normalized": [] }, { "id": "DS.d265.s1.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d265.s1.e0", "arg2_id": "DS.d265.s1.e2", "normalized": [] }, { "id": "DS.d265.s1.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d265.s1.e0", "arg2_id": "DS.d265.s1.e3", "normalized": [] } ]
DS.d268
18509327
[ { "id": "DS.d268.s0", "type": "", "text": [ "However, the simultaneous presence of the CYP3A4 *1B and CYP3A5 *1A alleles was associated with a 64% increase in docetaxel clearance (P = 0.0015), independent of both sex and CYP3A activity (as determined using the erythromycin breath test)." ], "offsets": [ [ 0, 242 ] ] } ]
[ { "id": "DS.d268.s0.e0", "type": "protein", "text": [ "CYP3A4" ], "offsets": [ [ 42, 48 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08684" } ] }, { "id": "DS.d268.s0.e1", "type": "protein", "text": [ "CYP3A5" ], "offsets": [ [ 57, 63 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P20815" } ] }, { "id": "DS.d268.s0.e2", "type": "compound", "text": [ "docetaxel" ], "offsets": [ [ 114, 123 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "148124" } ] } ]
[]
[]
[ { "id": "DS.d268.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d268.s0.e2", "arg2_id": "DS.d268.s0.e0", "normalized": [] }, { "id": "DS.d268.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d268.s0.e2", "arg2_id": "DS.d268.s0.e1", "normalized": [] } ]
DS.d269
18509591
[ { "id": "DS.d269.s0", "type": "", "text": [ "It was found that taurine administration produced lower levels of aspartate aminotransferase and alkaline aminotransferase than that of the untreated group." ], "offsets": [ [ 0, 156 ] ] }, { "id": "DS.d269.s1", "type": "", "text": [ "In addition, the levels of hepatic total protein, glutathione and superoxide dismutase were higher in the taurine treated groups than those in the untreated control or the taurine depleted groups, while hepatic malondialdehyde content exhibited the negative effect." ], "offsets": [ [ 157, 422 ] ] }, { "id": "DS.d269.s2", "type": "", "text": [ "Moreover, the concentrations of hepatic hydroxyproline, serum hyaluronic acid, interleukin-2, interleukin-6, tumor necrosis factor-alpha and laminin were all decreased in the taurine treated groups." ], "offsets": [ [ 423, 621 ] ] } ]
[ { "id": "DS.d269.s0.e0", "type": "compound", "text": [ "taurine" ], "offsets": [ [ 18, 25 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1123" } ] }, { "id": "DS.d269.s0.e1", "type": "protein", "text": [ "aspartate aminotransferase" ], "offsets": [ [ 66, 92 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O33822" }, { "db_name": "UniProt", "db_id": "O58489" }, { "db_name": "UniProt", "db_id": "O67781" }, { "db_name": "UniProt", "db_id": "O86459" }, { "db_name": "UniProt", "db_id": "O93744" }, { "db_name": "UniProt", "db_id": "P00509" }, { "db_name": "UniProt", "db_id": "P14909" }, { "db_name": "UniProt", "db_id": "P23034" }, { "db_name": "UniProt", "db_id": "P44425" }, { "db_name": "UniProt", "db_id": "P53001" }, { "db_name": "UniProt", "db_id": "P58661" }, { "db_name": "UniProt", "db_id": "P72173" }, { "db_name": "UniProt", "db_id": "Q4J8X2" }, { "db_name": "UniProt", "db_id": "Q55128" }, { "db_name": "UniProt", "db_id": "Q56114" }, { "db_name": "UniProt", "db_id": "Q56232" }, { "db_name": "UniProt", "db_id": "Q59228" }, { "db_name": "UniProt", "db_id": "Q60013" }, { "db_name": "UniProt", "db_id": "Q92JE7" }, { "db_name": "UniProt", "db_id": "Q972A2" }, { "db_name": "UniProt", "db_id": "Q9V0L2" }, { "db_name": "UniProt", "db_id": "Q9X0Y2" }, { "db_name": "UniProt", "db_id": "Q9ZE56" } ] }, { "id": "DS.d269.s1.e0", "type": "compound", "text": [ "glutathione" ], "offsets": [ [ 207, 218 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d269.s1.e1", "type": "protein", "text": [ "superoxide dismutase" ], "offsets": [ [ 223, 243 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O50258" } ] }, { "id": "DS.d269.s1.e2", "type": "compound", "text": [ "taurine" ], "offsets": [ [ 263, 270 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1123" } ] }, { "id": "DS.d269.s1.e3", "type": "compound", "text": [ "taurine" ], "offsets": [ [ 329, 336 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1123" } ] }, { "id": "DS.d269.s1.e4", "type": "compound", "text": [ "malondialdehyde" ], "offsets": [ [ 368, 383 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10964" } ] }, { "id": "DS.d269.s2.e0", "type": "compound", "text": [ "hydroxyproline" ], "offsets": [ [ 463, 477 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "825" }, { "db_name": "PubChem", "db_id": "5810" }, { "db_name": "PubChem", "db_id": "69248" }, { "db_name": "PubChem", "db_id": "440015" } ] }, { "id": "DS.d269.s2.e1", "type": "compound", "text": [ "hyaluronic acid" ], "offsets": [ [ 485, 500 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "24759" }, { "db_name": "PubChem", "db_id": "453618" }, { "db_name": "PubChem", "db_id": "3084050" }, { "db_name": "PubChem", "db_id": "24728612" } ] }, { "id": "DS.d269.s2.e2", "type": "protein", "text": [ "interleukin-6" ], "offsets": [ [ 517, 530 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P41693" } ] }, { "id": "DS.d269.s2.e3", "type": "protein", "text": [ "tumor necrosis factor" ], "offsets": [ [ 532, 553 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q8JFG3" } ] }, { "id": "DS.d269.s2.e4", "type": "compound", "text": [ "laminin" ], "offsets": [ [ 564, 571 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "44342165" } ] }, { "id": "DS.d269.s2.e5", "type": "compound", "text": [ "taurine" ], "offsets": [ [ 598, 605 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1123" } ] } ]
[]
[]
[ { "id": "DS.d269.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d269.s0.e0", "arg2_id": "DS.d269.s0.e1", "normalized": [] }, { "id": "DS.d269.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d269.s1.e2", "arg2_id": "DS.d269.s1.e1", "normalized": [] }, { "id": "DS.d269.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d269.s1.e4", "arg2_id": "DS.d269.s1.e1", "normalized": [] }, { "id": "DS.d269.s2.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d269.s2.e5", "arg2_id": "DS.d269.s2.e3", "normalized": [] }, { "id": "DS.d269.s2.i4", "type": "compound-protein-interaction", "arg1_id": "DS.d269.s2.e5", "arg2_id": "DS.d269.s2.e2", "normalized": [] } ]
DS.d270
18509644
[ { "id": "DS.d270.s0", "type": "", "text": [ "Pharmacological (flavopiridol) and molecular (shRNA) transcription inhibitor were used to impede formation of MET transcripts." ], "offsets": [ [ 0, 126 ] ] } ]
[ { "id": "DS.d270.s0.e0", "type": "compound", "text": [ "flavopiridol" ], "offsets": [ [ 17, 29 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5287969" } ] }, { "id": "DS.d270.s0.e1", "type": "protein", "text": [ "MET" ], "offsets": [ [ 110, 113 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08581" }, { "db_name": "UniProt", "db_id": "Q07DV8" }, { "db_name": "UniProt", "db_id": "Q07DY1" }, { "db_name": "UniProt", "db_id": "Q07DZ1" }, { "db_name": "UniProt", "db_id": "Q07E01" }, { "db_name": "UniProt", "db_id": "Q07E24" }, { "db_name": "UniProt", "db_id": "Q07E37" }, { "db_name": "UniProt", "db_id": "Q07E48" }, { "db_name": "UniProt", "db_id": "Q09YH7" }, { "db_name": "UniProt", "db_id": "Q09YI9" }, { "db_name": "UniProt", "db_id": "Q09YK0" }, { "db_name": "UniProt", "db_id": "Q09YL1" }, { "db_name": "UniProt", "db_id": "Q09YN5" }, { "db_name": "UniProt", "db_id": "Q108U6" }, { "db_name": "UniProt", "db_id": "Q2IBA6" }, { "db_name": "UniProt", "db_id": "Q2IBC0" }, { "db_name": "UniProt", "db_id": "Q2IBD8" }, { "db_name": "UniProt", "db_id": "Q2IBF2" }, { "db_name": "UniProt", "db_id": "Q2IBG7" }, { "db_name": "UniProt", "db_id": "Q2QL89" }, { "db_name": "UniProt", "db_id": "Q2QLA9" }, { "db_name": "UniProt", "db_id": "Q2QLC0" }, { "db_name": "UniProt", "db_id": "Q2QLE0" }, { "db_name": "UniProt", "db_id": "Q2QLF1" }, { "db_name": "UniProt", "db_id": "Q2QLG5" }, { "db_name": "UniProt", "db_id": "Q2QLH6" }, { "db_name": "UniProt", "db_id": "Q42662" }, { "db_name": "UniProt", "db_id": "Q75ZY9" } ] } ]
[]
[]
[ { "id": "DS.d270.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d270.s0.e0", "arg2_id": "DS.d270.s0.e1", "normalized": [] } ]
DS.d271
18509748
[ { "id": "DS.d271.s0", "type": "", "text": [ "Effect of small interference RNA targeting HIF-1alpha mediated by rAAV combined L:-ascorbate on pancreatic tumors in athymic mice." ], "offsets": [ [ 0, 130 ] ] } ]
[ { "id": "DS.d271.s0.e0", "type": "protein", "text": [ "HIF-1alpha" ], "offsets": [ [ 43, 53 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35800" }, { "db_name": "UniProt", "db_id": "Q0PGG7" }, { "db_name": "UniProt", "db_id": "Q16665" }, { "db_name": "UniProt", "db_id": "Q309Z6" }, { "db_name": "UniProt", "db_id": "Q61221" }, { "db_name": "UniProt", "db_id": "Q98SW2" }, { "db_name": "UniProt", "db_id": "Q9I8A9" }, { "db_name": "UniProt", "db_id": "Q9XTA5" }, { "db_name": "UniProt", "db_id": "Q9YIB9" } ] }, { "id": "DS.d271.s0.e1", "type": "compound", "text": [ "L:-ascorbate" ], "offsets": [ [ 80, 92 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "54690394" } ] } ]
[]
[]
[]
DS.d272
18511076
[ { "id": "DS.d272.s0", "type": "", "text": [ "Changes in BDNF serum levels in patients with major depression disorder (MDD) after 6 months treatment with sertraline, escitalopram, or venlafaxine." ], "offsets": [ [ 0, 149 ] ] }, { "id": "DS.d272.s1", "type": "", "text": [ "We assessed serum BDNF levels in 21 patients with major depressive episode treated with sertraline, escitalopram, or venlafaxine and 20 healthy controls." ], "offsets": [ [ 150, 303 ] ] }, { "id": "DS.d272.s2", "type": "", "text": [ "Sertraline increased BDNF levels after 5 weeks and 6 months of treatment." ], "offsets": [ [ 304, 377 ] ] }, { "id": "DS.d272.s3", "type": "", "text": [ "Venlafaxine increased BDNF levels only after 6 months." ], "offsets": [ [ 378, 432 ] ] }, { "id": "DS.d272.s4", "type": "", "text": [ "Escitalopram did not affect BDNF levels at either time point." ], "offsets": [ [ 433, 494 ] ] } ]
[ { "id": "DS.d272.s0.e0", "type": "protein", "text": [ "BDNF" ], "offsets": [ [ 11, 15 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18752" }, { "db_name": "UniProt", "db_id": "O18753" }, { "db_name": "UniProt", "db_id": "O18755" }, { "db_name": "UniProt", "db_id": "O70183" }, { "db_name": "UniProt", "db_id": "O97759" }, { "db_name": "UniProt", "db_id": "P14082" }, { "db_name": "UniProt", "db_id": "P21237" }, { "db_name": "UniProt", "db_id": "P23363" }, { "db_name": "UniProt", "db_id": "P23560" }, { "db_name": "UniProt", "db_id": "P25429" }, { "db_name": "UniProt", "db_id": "P25430" }, { "db_name": "UniProt", "db_id": "P25431" }, { "db_name": "UniProt", "db_id": "P25432" }, { "db_name": "UniProt", "db_id": "Q02193" }, { "db_name": "UniProt", "db_id": "Q06225" }, { "db_name": "UniProt", "db_id": "Q3SAT7" }, { "db_name": "UniProt", "db_id": "Q4L0Y3" }, { "db_name": "UniProt", "db_id": "Q5IS78" }, { "db_name": "UniProt", "db_id": "Q6LCI5" }, { "db_name": "UniProt", "db_id": "Q7YRB4" }, { "db_name": "UniProt", "db_id": "Q90322" }, { "db_name": "UniProt", "db_id": "Q95106" }, { "db_name": "UniProt", "db_id": "Q9TST3" } ] }, { "id": "DS.d272.s0.e1", "type": "compound", "text": [ "sertraline" ], "offsets": [ [ 108, 118 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "68617" } ] }, { "id": "DS.d272.s0.e2", "type": "compound", "text": [ "escitalopram" ], "offsets": [ [ 120, 132 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "146570" } ] }, { "id": "DS.d272.s0.e3", "type": "compound", "text": [ "venlafaxine" ], "offsets": [ [ 137, 148 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5656" } ] }, { "id": "DS.d272.s1.e0", "type": "protein", "text": [ "BDNF" ], "offsets": [ [ 168, 172 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18752" }, { "db_name": "UniProt", "db_id": "O18753" }, { "db_name": "UniProt", "db_id": "O18755" }, { "db_name": "UniProt", "db_id": "O70183" }, { "db_name": "UniProt", "db_id": "O97759" }, { "db_name": "UniProt", "db_id": "P14082" }, { "db_name": "UniProt", "db_id": "P21237" }, { "db_name": "UniProt", "db_id": "P23363" }, { "db_name": "UniProt", "db_id": "P23560" }, { "db_name": "UniProt", "db_id": "P25429" }, { "db_name": "UniProt", "db_id": "P25430" }, { "db_name": "UniProt", "db_id": "P25431" }, { "db_name": "UniProt", "db_id": "P25432" }, { "db_name": "UniProt", "db_id": "Q02193" }, { "db_name": "UniProt", "db_id": "Q06225" }, { "db_name": "UniProt", "db_id": "Q3SAT7" }, { "db_name": "UniProt", "db_id": "Q4L0Y3" }, { "db_name": "UniProt", "db_id": "Q5IS78" }, { "db_name": "UniProt", "db_id": "Q6LCI5" }, { "db_name": "UniProt", "db_id": "Q7YRB4" }, { "db_name": "UniProt", "db_id": "Q90322" }, { "db_name": "UniProt", "db_id": "Q95106" }, { "db_name": "UniProt", "db_id": "Q9TST3" } ] }, { "id": "DS.d272.s1.e1", "type": "compound", "text": [ "sertraline" ], "offsets": [ [ 238, 248 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "68617" } ] }, { "id": "DS.d272.s1.e2", "type": "compound", "text": [ "escitalopram" ], "offsets": [ [ 250, 262 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "146570" } ] }, { "id": "DS.d272.s1.e3", "type": "compound", "text": [ "venlafaxine" ], "offsets": [ [ 267, 278 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5656" } ] }, { "id": "DS.d272.s2.e0", "type": "compound", "text": [ "Sertraline" ], "offsets": [ [ 304, 314 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "68617" } ] }, { "id": "DS.d272.s2.e1", "type": "protein", "text": [ "BDNF" ], "offsets": [ [ 325, 329 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18752" }, { "db_name": "UniProt", "db_id": "O18753" }, { "db_name": "UniProt", "db_id": "O18755" }, { "db_name": "UniProt", "db_id": "O70183" }, { "db_name": "UniProt", "db_id": "O97759" }, { "db_name": "UniProt", "db_id": "P14082" }, { "db_name": "UniProt", "db_id": "P21237" }, { "db_name": "UniProt", "db_id": "P23363" }, { "db_name": "UniProt", "db_id": "P23560" }, { "db_name": "UniProt", "db_id": "P25429" }, { "db_name": "UniProt", "db_id": "P25430" }, { "db_name": "UniProt", "db_id": "P25431" }, { "db_name": "UniProt", "db_id": "P25432" }, { "db_name": "UniProt", "db_id": "Q02193" }, { "db_name": "UniProt", "db_id": "Q06225" }, { "db_name": "UniProt", "db_id": "Q3SAT7" }, { "db_name": "UniProt", "db_id": "Q4L0Y3" }, { "db_name": "UniProt", "db_id": "Q5IS78" }, { "db_name": "UniProt", "db_id": "Q6LCI5" }, { "db_name": "UniProt", "db_id": "Q7YRB4" }, { "db_name": "UniProt", "db_id": "Q90322" }, { "db_name": "UniProt", "db_id": "Q95106" }, { "db_name": "UniProt", "db_id": "Q9TST3" } ] }, { "id": "DS.d272.s3.e0", "type": "compound", "text": [ "Venlafaxine" ], "offsets": [ [ 378, 389 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5656" } ] }, { "id": "DS.d272.s3.e1", "type": "protein", "text": [ "BDNF" ], "offsets": [ [ 400, 404 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18752" }, { "db_name": "UniProt", "db_id": "O18753" }, { "db_name": "UniProt", "db_id": "O18755" }, { "db_name": "UniProt", "db_id": "O70183" }, { "db_name": "UniProt", "db_id": "O97759" }, { "db_name": "UniProt", "db_id": "P14082" }, { "db_name": "UniProt", "db_id": "P21237" }, { "db_name": "UniProt", "db_id": "P23363" }, { "db_name": "UniProt", "db_id": "P23560" }, { "db_name": "UniProt", "db_id": "P25429" }, { "db_name": "UniProt", "db_id": "P25430" }, { "db_name": "UniProt", "db_id": "P25431" }, { "db_name": "UniProt", "db_id": "P25432" }, { "db_name": "UniProt", "db_id": "Q02193" }, { "db_name": "UniProt", "db_id": "Q06225" }, { "db_name": "UniProt", "db_id": "Q3SAT7" }, { "db_name": "UniProt", "db_id": "Q4L0Y3" }, { "db_name": "UniProt", "db_id": "Q5IS78" }, { "db_name": "UniProt", "db_id": "Q6LCI5" }, { "db_name": "UniProt", "db_id": "Q7YRB4" }, { "db_name": "UniProt", "db_id": "Q90322" }, { "db_name": "UniProt", "db_id": "Q95106" }, { "db_name": "UniProt", "db_id": "Q9TST3" } ] }, { "id": "DS.d272.s4.e0", "type": "compound", "text": [ "Escitalopram" ], "offsets": [ [ 433, 445 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "146570" } ] }, { "id": "DS.d272.s4.e1", "type": "protein", "text": [ "BDNF" ], "offsets": [ [ 461, 465 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18752" }, { "db_name": "UniProt", "db_id": "O18753" }, { "db_name": "UniProt", "db_id": "O18755" }, { "db_name": "UniProt", "db_id": "O70183" }, { "db_name": "UniProt", "db_id": "O97759" }, { "db_name": "UniProt", "db_id": "P14082" }, { "db_name": "UniProt", "db_id": "P21237" }, { "db_name": "UniProt", "db_id": "P23363" }, { "db_name": "UniProt", "db_id": "P23560" }, { "db_name": "UniProt", "db_id": "P25429" }, { "db_name": "UniProt", "db_id": "P25430" }, { "db_name": "UniProt", "db_id": "P25431" }, { "db_name": "UniProt", "db_id": "P25432" }, { "db_name": "UniProt", "db_id": "Q02193" }, { "db_name": "UniProt", "db_id": "Q06225" }, { "db_name": "UniProt", "db_id": "Q3SAT7" }, { "db_name": "UniProt", "db_id": "Q4L0Y3" }, { "db_name": "UniProt", "db_id": "Q5IS78" }, { "db_name": "UniProt", "db_id": "Q6LCI5" }, { "db_name": "UniProt", "db_id": "Q7YRB4" }, { "db_name": "UniProt", "db_id": "Q90322" }, { "db_name": "UniProt", "db_id": "Q95106" }, { "db_name": "UniProt", "db_id": "Q9TST3" } ] } ]
[]
[]
[ { "id": "DS.d272.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d272.s0.e3", "arg2_id": "DS.d272.s0.e0", "normalized": [] }, { "id": "DS.d272.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d272.s0.e1", "arg2_id": "DS.d272.s0.e0", "normalized": [] }, { "id": "DS.d272.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d272.s0.e2", "arg2_id": "DS.d272.s0.e0", "normalized": [] }, { "id": "DS.d272.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d272.s1.e3", "arg2_id": "DS.d272.s1.e0", "normalized": [] }, { "id": "DS.d272.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d272.s1.e1", "arg2_id": "DS.d272.s1.e0", "normalized": [] }, { "id": "DS.d272.s1.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d272.s1.e2", "arg2_id": "DS.d272.s1.e0", "normalized": [] }, { "id": "DS.d272.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d272.s2.e0", "arg2_id": "DS.d272.s2.e1", "normalized": [] }, { "id": "DS.d272.s3.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d272.s3.e0", "arg2_id": "DS.d272.s3.e1", "normalized": [] } ]
DS.d273
18513727
[ { "id": "DS.d273.s0", "type": "", "text": [ "The increase of cholesterol was accompanied by a marked posttranslational down-regulation of liver SR-BI expression." ], "offsets": [ [ 0, 116 ] ] }, { "id": "DS.d273.s1", "type": "", "text": [ "Taken together, a diet-induced increase of plasma and hepatic cholesterol levels leads to a posttranscriptional down-regulation of SR-BI in mouse liver via a mechanism likely involving PDZK1." ], "offsets": [ [ 117, 308 ] ] } ]
[ { "id": "DS.d273.s0.e0", "type": "compound", "text": [ "cholesterol" ], "offsets": [ [ 16, 27 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "304" }, { "db_name": "PubChem", "db_id": "5997" }, { "db_name": "PubChem", "db_id": "6432564" }, { "db_name": "PubChem", "db_id": "11025495" } ] }, { "id": "DS.d273.s0.e1", "type": "protein", "text": [ "SR-BI" ], "offsets": [ [ 99, 104 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18824" }, { "db_name": "UniProt", "db_id": "P97943" }, { "db_name": "UniProt", "db_id": "Q60417" }, { "db_name": "UniProt", "db_id": "Q61009" }, { "db_name": "UniProt", "db_id": "Q8SQC1" }, { "db_name": "UniProt", "db_id": "Q8WTV0" } ] }, { "id": "DS.d273.s1.e0", "type": "compound", "text": [ "cholesterol" ], "offsets": [ [ 179, 190 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "304" }, { "db_name": "PubChem", "db_id": "5997" }, { "db_name": "PubChem", "db_id": "6432564" }, { "db_name": "PubChem", "db_id": "11025495" } ] }, { "id": "DS.d273.s1.e1", "type": "protein", "text": [ "SR-BI" ], "offsets": [ [ 248, 253 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18824" }, { "db_name": "UniProt", "db_id": "P97943" }, { "db_name": "UniProt", "db_id": "Q60417" }, { "db_name": "UniProt", "db_id": "Q61009" }, { "db_name": "UniProt", "db_id": "Q8SQC1" }, { "db_name": "UniProt", "db_id": "Q8WTV0" } ] }, { "id": "DS.d273.s1.e2", "type": "protein", "text": [ "PDZK1" ], "offsets": [ [ 302, 307 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q3T0X8" }, { "db_name": "UniProt", "db_id": "Q5RCF7" }, { "db_name": "UniProt", "db_id": "Q5T2W1" }, { "db_name": "UniProt", "db_id": "Q865P3" } ] } ]
[]
[]
[ { "id": "DS.d273.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d273.s1.e0", "arg2_id": "DS.d273.s1.e1", "normalized": [] } ]
DS.d274
18513857
[ { "id": "DS.d274.s0", "type": "", "text": [ "A 5.5 kilobase-pair (kbp) Pst1-Kpn1 fragment containing gene(s) encoding for zearalenone degradation was cloned." ], "offsets": [ [ 0, 112 ] ] } ]
[ { "id": "DS.d274.s0.e0", "type": "protein", "text": [ "Pst1" ], "offsets": [ [ 26, 30 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q09750" } ] }, { "id": "DS.d274.s0.e1", "type": "compound", "text": [ "zearalenone" ], "offsets": [ [ 77, 88 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5281576" } ] } ]
[]
[]
[ { "id": "DS.d274.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d274.s0.e1", "arg2_id": "DS.d274.s0.e0", "normalized": [] } ]
DS.d275
18514659
[ { "id": "DS.d275.s0", "type": "", "text": [ "However, TXA(2) formation remains elevated in patients with cardiovascular disease on doses of aspirin that fully suppress platelet COX-1, suggesting other tissue sources for TXA(2) formation." ], "offsets": [ [ 0, 192 ] ] } ]
[ { "id": "DS.d275.s0.e0", "type": "compound", "text": [ "TXA(2" ], "offsets": [ [ 9, 14 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280497" } ] }, { "id": "DS.d275.s0.e1", "type": "compound", "text": [ "aspirin" ], "offsets": [ [ 95, 102 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2244" } ] }, { "id": "DS.d275.s0.e2", "type": "protein", "text": [ "COX-1" ], "offsets": [ [ 132, 137 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62664" }, { "db_name": "UniProt", "db_id": "O97554" }, { "db_name": "UniProt", "db_id": "P05979" }, { "db_name": "UniProt", "db_id": "P22437" }, { "db_name": "UniProt", "db_id": "P23219" }, { "db_name": "UniProt", "db_id": "Q63921" }, { "db_name": "UniProt", "db_id": "Q9T0N8" } ] }, { "id": "DS.d275.s0.e3", "type": "compound", "text": [ "TXA(2" ], "offsets": [ [ 175, 180 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280497" } ] } ]
[]
[]
[ { "id": "DS.d275.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d275.s0.e1", "arg2_id": "DS.d275.s0.e2", "normalized": [] } ]
DS.d276
18514900
[ { "id": "DS.d276.s0", "type": "", "text": [ ") production increased; metallothionein (MT) and glutathione levels increased in most cases, and acetylcholinesterase (AChE) activity decreased in summer." ], "offsets": [ [ 0, 154 ] ] } ]
[ { "id": "DS.d276.s0.e0", "type": "protein", "text": [ "metallothionein" ], "offsets": [ [ 24, 39 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02033" }, { "db_name": "UniProt", "db_id": "O13257" }, { "db_name": "UniProt", "db_id": "O18842" }, { "db_name": "UniProt", "db_id": "O42152" }, { "db_name": "UniProt", "db_id": "O93571" }, { "db_name": "UniProt", "db_id": "P02807" }, { "db_name": "UniProt", "db_id": "P04358" }, { "db_name": "UniProt", "db_id": "P07216" }, { "db_name": "UniProt", "db_id": "P08002" }, { "db_name": "UniProt", "db_id": "P23038" }, { "db_name": "UniProt", "db_id": "P25127" }, { "db_name": "UniProt", "db_id": "P25128" }, { "db_name": "UniProt", "db_id": "P30331" }, { "db_name": "UniProt", "db_id": "P30565" }, { "db_name": "UniProt", "db_id": "P51902" }, { "db_name": "UniProt", "db_id": "P52723" }, { "db_name": "UniProt", "db_id": "P52725" }, { "db_name": "UniProt", "db_id": "P52726" }, { "db_name": "UniProt", "db_id": "P52728" }, { "db_name": "UniProt", "db_id": "P55945" }, { "db_name": "UniProt", "db_id": "P55946" }, { "db_name": "UniProt", "db_id": "P55948" }, { "db_name": "UniProt", "db_id": "P55951" }, { "db_name": "UniProt", "db_id": "P55952" }, { "db_name": "UniProt", "db_id": "P55953" }, { "db_name": "UniProt", "db_id": "P68494" }, { "db_name": "UniProt", "db_id": "P68495" }, { "db_name": "UniProt", "db_id": "P68497" }, { "db_name": "UniProt", "db_id": "P68498" }, { "db_name": "UniProt", "db_id": "P68499" }, { "db_name": "UniProt", "db_id": "P80367" }, { "db_name": "UniProt", "db_id": "P80593" }, { "db_name": "UniProt", "db_id": "P84865" }, { "db_name": "UniProt", "db_id": "Q05890" }, { "db_name": "UniProt", "db_id": "Q6J1T3" }, { "db_name": "UniProt", "db_id": "Q6S4N8" }, { "db_name": "UniProt", "db_id": "Q6XUW5" }, { "db_name": "UniProt", "db_id": "Q708T3" }, { "db_name": "UniProt", "db_id": "Q7ZZP9" }, { "db_name": "UniProt", "db_id": "Q800D3" }, { "db_name": "UniProt", "db_id": "Q8UVY1" }, { "db_name": "UniProt", "db_id": "Q94550" }, { "db_name": "UniProt", "db_id": "Q9IB50" }, { "db_name": "UniProt", "db_id": "Q9U568" } ] }, { "id": "DS.d276.s0.e1", "type": "compound", "text": [ "glutathione" ], "offsets": [ [ 49, 60 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d276.s0.e2", "type": "protein", "text": [ "acetylcholinesterase" ], "offsets": [ [ 97, 117 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q867X2" }, { "db_name": "UniProt", "db_id": "Q867X3" }, { "db_name": "UniProt", "db_id": "Q86GC9" }, { "db_name": "UniProt", "db_id": "Q92081" } ] }, { "id": "DS.d276.s0.e3", "type": "protein", "text": [ "AChE" ], "offsets": [ [ 119, 123 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42275" }, { "db_name": "UniProt", "db_id": "O62763" }, { "db_name": "UniProt", "db_id": "P04058" }, { "db_name": "UniProt", "db_id": "P07140" }, { "db_name": "UniProt", "db_id": "P07692" }, { "db_name": "UniProt", "db_id": "P21836" }, { "db_name": "UniProt", "db_id": "P22303" }, { "db_name": "UniProt", "db_id": "P23795" }, { "db_name": "UniProt", "db_id": "P36196" }, { "db_name": "UniProt", "db_id": "P37136" }, { "db_name": "UniProt", "db_id": "P56161" }, { "db_name": "UniProt", "db_id": "Q27677" }, { "db_name": "UniProt", "db_id": "Q29499" }, { "db_name": "UniProt", "db_id": "Q867X2" }, { "db_name": "UniProt", "db_id": "Q867X3" }, { "db_name": "UniProt", "db_id": "Q869C3" }, { "db_name": "UniProt", "db_id": "Q86GC8" }, { "db_name": "UniProt", "db_id": "Q86GC9" }, { "db_name": "UniProt", "db_id": "Q92035" }, { "db_name": "UniProt", "db_id": "Q92081" }, { "db_name": "UniProt", "db_id": "Q9DDE3" } ] } ]
[]
[]
[]
DS.d277
18515453
[ { "id": "DS.d277.s0", "type": "", "text": [ "From these findings, it is suggested that distigmine bromide may produce centrally mediated behavioural signs by increasing the ACh levels in the brain, resulting from its AChE and BuChE inhibitions." ], "offsets": [ [ 0, 199 ] ] } ]
[ { "id": "DS.d277.s0.e0", "type": "compound", "text": [ "distigmine bromide" ], "offsets": [ [ 42, 60 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3116" } ] }, { "id": "DS.d277.s0.e1", "type": "protein", "text": [ "AChE" ], "offsets": [ [ 172, 176 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42275" }, { "db_name": "UniProt", "db_id": "O62763" }, { "db_name": "UniProt", "db_id": "P04058" }, { "db_name": "UniProt", "db_id": "P07140" }, { "db_name": "UniProt", "db_id": "P07692" }, { "db_name": "UniProt", "db_id": "P21836" }, { "db_name": "UniProt", "db_id": "P22303" }, { "db_name": "UniProt", "db_id": "P23795" }, { "db_name": "UniProt", "db_id": "P36196" }, { "db_name": "UniProt", "db_id": "P37136" }, { "db_name": "UniProt", "db_id": "P56161" }, { "db_name": "UniProt", "db_id": "Q27677" }, { "db_name": "UniProt", "db_id": "Q29499" }, { "db_name": "UniProt", "db_id": "Q867X2" }, { "db_name": "UniProt", "db_id": "Q867X3" }, { "db_name": "UniProt", "db_id": "Q869C3" }, { "db_name": "UniProt", "db_id": "Q86GC8" }, { "db_name": "UniProt", "db_id": "Q86GC9" }, { "db_name": "UniProt", "db_id": "Q92035" }, { "db_name": "UniProt", "db_id": "Q92081" }, { "db_name": "UniProt", "db_id": "Q9DDE3" } ] } ]
[]
[]
[ { "id": "DS.d277.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d277.s0.e0", "arg2_id": "DS.d277.s0.e1", "normalized": [] } ]
DS.d278
18515457
[ { "id": "DS.d278.s0", "type": "", "text": [ "Using DBA/2OlaHsd mice, we investigated the effects of chronic social defeat and concomitant treatment with R121919/NBI 30775 on 1) the behavioural profile in the modified hole board test and 2) in-situ hybridization analysis-based expression of arginine vasopressin (AVP) and CRH mRNA in both the hypothalamic paraventricular nucleus and supraoptic nucleus." ], "offsets": [ [ 0, 358 ] ] } ]
[ { "id": "DS.d278.s0.e0", "type": "compound", "text": [ "R121919" ], "offsets": [ [ 108, 115 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "9821250" } ] }, { "id": "DS.d278.s0.e2", "type": "protein", "text": [ "AVP" ], "offsets": [ [ 268, 271 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01180" }, { "db_name": "UniProt", "db_id": "P01181" }, { "db_name": "UniProt", "db_id": "P01182" }, { "db_name": "UniProt", "db_id": "P01183" }, { "db_name": "UniProt", "db_id": "P01184" }, { "db_name": "UniProt", "db_id": "P01185" }, { "db_name": "UniProt", "db_id": "P10769" }, { "db_name": "UniProt", "db_id": "P31414" }, { "db_name": "UniProt", "db_id": "P81768" } ] }, { "id": "DS.d278.s0.e3", "type": "protein", "text": [ "CRH" ], "offsets": [ [ 277, 280 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01142" }, { "db_name": "UniProt", "db_id": "P06296" }, { "db_name": "UniProt", "db_id": "P06850" }, { "db_name": "UniProt", "db_id": "P49926" }, { "db_name": "UniProt", "db_id": "Q95MI6" }, { "db_name": "UniProt", "db_id": "Q9PTS1" } ] } ]
[]
[]
[]
DS.d279
18515973
[ { "id": "DS.d279.s0", "type": "", "text": [ "7-Ketocholesterol also enhanced IL-6 release from VSMC." ], "offsets": [ [ 0, 55 ] ] }, { "id": "DS.d279.s1", "type": "", "text": [ "IL-6 release by 7-ketocholesterol, although significant, was not as remarkable as that induced by TNF-alpha." ], "offsets": [ [ 56, 164 ] ] }, { "id": "DS.d279.s2", "type": "", "text": [ "These data suggest that 7-ketocholesterol upregulates IL-6 via mechanisms distinct from TNF-alpha and contributes to the intra- and extracellular IL-6 deposits within the vasculature." ], "offsets": [ [ 165, 348 ] ] }, { "id": "DS.d279.s3", "type": "", "text": [ "7-Ketocholesterol upregulates interleukin-6 via mechanisms that are distinct from those of tumor necrosis factor-alpha, in vascular smooth muscle cells." ], "offsets": [ [ 349, 501 ] ] }, { "id": "DS.d279.s4", "type": "", "text": [ "Among the 7 IL examined, only IL-6 transcript was increased by 7-ketocholesterol treatment in human aorta smooth muscle cells." ], "offsets": [ [ 502, 628 ] ] }, { "id": "DS.d279.s5", "type": "", "text": [ "IL-6 transcripts increased up to 24 h after treatment with 7-ketocholesterol, and this effect was profoundly repressed by treatment with p38 MAPK inhibitors and to a lesser extent JNK inhibitors." ], "offsets": [ [ 629, 824 ] ] }, { "id": "DS.d279.s6", "type": "", "text": [ "7alpha-Hydroxycholesterol, 27-hydroxycholesterol or cholesterol, however, did not induce IL-6 expression." ], "offsets": [ [ 825, 930 ] ] }, { "id": "DS.d279.s7", "type": "", "text": [ "Mechanisms of IL-6 induction by 7-ketocholesterol were investigated in comparison with tumor necrosis factor (TNF)-alpha." ], "offsets": [ [ 931, 1052 ] ] }, { "id": "DS.d279.s8", "type": "", "text": [ "Whereas TNF-alpha activated IL-6 promoter, which was impaired by p38 MAPK inhibitors or by mutation in the NF-kappaB-binding site within the promoter region, 7-ketocholesterol did not affect IL-6 promoter activity." ], "offsets": [ [ 1053, 1267 ] ] }, { "id": "DS.d279.s9", "type": "", "text": [ "7-ketocholesterol significantly increased the amount of intracellular IL-6 protein in the presence of brefeldin A." ], "offsets": [ [ 1268, 1382 ] ] } ]
[ { "id": "DS.d279.s0.e0", "type": "compound", "text": [ "7-Ketocholesterol" ], "offsets": [ [ 0, 17 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "91474" } ] }, { "id": "DS.d279.s0.e1", "type": "protein", "text": [ "IL-6" ], "offsets": [ [ 32, 36 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35736" }, { "db_name": "UniProt", "db_id": "P05231" }, { "db_name": "UniProt", "db_id": "P08505" }, { "db_name": "UniProt", "db_id": "P20607" }, { "db_name": "UniProt", "db_id": "P26892" }, { "db_name": "UniProt", "db_id": "P26893" }, { "db_name": "UniProt", "db_id": "P29455" }, { "db_name": "UniProt", "db_id": "P41323" }, { "db_name": "UniProt", "db_id": "P41683" }, { "db_name": "UniProt", "db_id": "P41693" }, { "db_name": "UniProt", "db_id": "P46650" }, { "db_name": "UniProt", "db_id": "P51494" }, { "db_name": "UniProt", "db_id": "P79341" }, { "db_name": "UniProt", "db_id": "Q25BC2" }, { "db_name": "UniProt", "db_id": "Q28319" }, { "db_name": "UniProt", "db_id": "Q28747" }, { "db_name": "UniProt", "db_id": "Q28819" }, { "db_name": "UniProt", "db_id": "Q2MH06" }, { "db_name": "UniProt", "db_id": "Q5I6E3" }, { "db_name": "UniProt", "db_id": "Q6V919" }, { "db_name": "UniProt", "db_id": "Q865W7" }, { "db_name": "UniProt", "db_id": "Q865X6" }, { "db_name": "UniProt", "db_id": "Q8MKH0" }, { "db_name": "UniProt", "db_id": "Q95181" }, { "db_name": "UniProt", "db_id": "Q9MZR1" }, { "db_name": "UniProt", "db_id": "Q9XT80" } ] }, { "id": "DS.d279.s1.e0", "type": "protein", "text": [ "IL-6" ], "offsets": [ [ 56, 60 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35736" }, { "db_name": "UniProt", "db_id": "P05231" }, { "db_name": "UniProt", "db_id": "P08505" }, { "db_name": "UniProt", "db_id": "P20607" }, { "db_name": "UniProt", "db_id": "P26892" }, { "db_name": "UniProt", "db_id": "P26893" }, { "db_name": "UniProt", "db_id": "P29455" }, { "db_name": "UniProt", "db_id": "P41323" }, { "db_name": "UniProt", "db_id": "P41683" }, { "db_name": "UniProt", "db_id": "P41693" }, { "db_name": "UniProt", "db_id": "P46650" }, { "db_name": "UniProt", "db_id": "P51494" }, { "db_name": "UniProt", "db_id": "P79341" }, { "db_name": "UniProt", "db_id": "Q25BC2" }, { "db_name": "UniProt", "db_id": "Q28319" }, { "db_name": "UniProt", "db_id": "Q28747" }, { "db_name": "UniProt", "db_id": "Q28819" }, { "db_name": "UniProt", "db_id": "Q2MH06" }, { "db_name": "UniProt", "db_id": "Q5I6E3" }, { "db_name": "UniProt", "db_id": "Q6V919" }, { "db_name": "UniProt", "db_id": "Q865W7" }, { "db_name": "UniProt", "db_id": "Q865X6" }, { "db_name": "UniProt", "db_id": "Q8MKH0" }, { "db_name": "UniProt", "db_id": "Q95181" }, { "db_name": "UniProt", "db_id": "Q9MZR1" }, { "db_name": "UniProt", "db_id": "Q9XT80" } ] }, { "id": "DS.d279.s1.e1", "type": "compound", "text": [ "7-ketocholesterol" ], "offsets": [ [ 72, 89 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "91474" } ] }, { "id": "DS.d279.s1.e2", "type": "protein", "text": [ "TNF-alpha" ], "offsets": [ [ 154, 163 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35734" }, { "db_name": "UniProt", "db_id": "O77510" }, { "db_name": "UniProt", "db_id": "O77764" }, { "db_name": "UniProt", "db_id": "P01375" }, { "db_name": "UniProt", "db_id": "P04924" }, { "db_name": "UniProt", "db_id": "P06804" }, { "db_name": "UniProt", "db_id": "P13296" }, { "db_name": "UniProt", "db_id": "P16599" }, { "db_name": "UniProt", "db_id": "P19101" }, { "db_name": "UniProt", "db_id": "P23383" }, { "db_name": "UniProt", "db_id": "P23563" }, { "db_name": "UniProt", "db_id": "P29553" }, { "db_name": "UniProt", "db_id": "P33620" }, { "db_name": "UniProt", "db_id": "P36939" }, { "db_name": "UniProt", "db_id": "P48094" }, { "db_name": "UniProt", "db_id": "P51435" }, { "db_name": "UniProt", "db_id": "P51742" }, { "db_name": "UniProt", "db_id": "P51743" }, { "db_name": "UniProt", "db_id": "P59684" }, { "db_name": "UniProt", "db_id": "P59693" }, { "db_name": "UniProt", "db_id": "P59694" }, { "db_name": "UniProt", "db_id": "P59695" }, { "db_name": "UniProt", "db_id": "P79337" }, { "db_name": "UniProt", "db_id": "P79374" }, { "db_name": "UniProt", "db_id": "Q06599" }, { "db_name": "UniProt", "db_id": "Q19LH4" }, { "db_name": "UniProt", "db_id": "Q1G1A2" }, { "db_name": "UniProt", "db_id": "Q1WM27" }, { "db_name": "UniProt", "db_id": "Q2MH05" }, { "db_name": "UniProt", "db_id": "Q539C2" }, { "db_name": "UniProt", "db_id": "Q75N23" }, { "db_name": "UniProt", "db_id": "Q8HZD9" }, { "db_name": "UniProt", "db_id": "Q8JFG3" }, { "db_name": "UniProt", "db_id": "Q8MKG8" }, { "db_name": "UniProt", "db_id": "Q8WNR1" }, { "db_name": "UniProt", "db_id": "Q9BEA1" } ] }, { "id": "DS.d279.s2.e0", "type": "compound", "text": [ "7-ketocholesterol" ], "offsets": [ [ 189, 206 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "91474" } ] }, { "id": "DS.d279.s2.e1", "type": "protein", "text": [ "IL-6" ], "offsets": [ [ 219, 223 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35736" }, { "db_name": "UniProt", "db_id": "P05231" }, { "db_name": "UniProt", "db_id": "P08505" }, { "db_name": "UniProt", "db_id": "P20607" }, { "db_name": "UniProt", "db_id": "P26892" }, { "db_name": "UniProt", "db_id": "P26893" }, { "db_name": "UniProt", "db_id": "P29455" }, { "db_name": "UniProt", "db_id": "P41323" }, { "db_name": "UniProt", "db_id": "P41683" }, { "db_name": "UniProt", "db_id": "P41693" }, { "db_name": "UniProt", "db_id": "P46650" }, { "db_name": "UniProt", "db_id": "P51494" }, { "db_name": "UniProt", "db_id": "P79341" }, { "db_name": "UniProt", "db_id": "Q25BC2" }, { "db_name": "UniProt", "db_id": "Q28319" }, { "db_name": "UniProt", "db_id": "Q28747" }, { "db_name": "UniProt", "db_id": "Q28819" }, { "db_name": "UniProt", "db_id": "Q2MH06" }, { "db_name": "UniProt", "db_id": "Q5I6E3" }, { "db_name": "UniProt", "db_id": "Q6V919" }, { "db_name": "UniProt", "db_id": "Q865W7" }, { "db_name": "UniProt", "db_id": "Q865X6" }, { "db_name": "UniProt", "db_id": "Q8MKH0" }, { "db_name": "UniProt", "db_id": "Q95181" }, { "db_name": "UniProt", "db_id": "Q9MZR1" }, { "db_name": "UniProt", "db_id": "Q9XT80" } ] }, { "id": "DS.d279.s2.e2", "type": "protein", "text": [ "TNF-alpha" ], "offsets": [ [ 253, 262 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35734" }, { "db_name": "UniProt", "db_id": "O77510" }, { "db_name": "UniProt", "db_id": "O77764" }, { "db_name": "UniProt", "db_id": "P01375" }, { "db_name": "UniProt", "db_id": "P04924" }, { "db_name": "UniProt", "db_id": "P06804" }, { "db_name": "UniProt", "db_id": "P13296" }, { "db_name": "UniProt", "db_id": "P16599" }, { "db_name": "UniProt", "db_id": "P19101" }, { "db_name": "UniProt", "db_id": "P23383" }, { "db_name": "UniProt", "db_id": "P23563" }, { "db_name": "UniProt", "db_id": "P29553" }, { "db_name": "UniProt", "db_id": "P33620" }, { "db_name": "UniProt", "db_id": "P36939" }, { "db_name": "UniProt", "db_id": "P48094" }, { "db_name": "UniProt", "db_id": "P51435" }, { "db_name": "UniProt", "db_id": "P51742" }, { "db_name": "UniProt", "db_id": "P51743" }, { "db_name": "UniProt", "db_id": "P59684" }, { "db_name": "UniProt", "db_id": "P59693" }, { "db_name": "UniProt", "db_id": "P59694" }, { "db_name": "UniProt", "db_id": "P59695" }, { "db_name": "UniProt", "db_id": "P79337" }, { "db_name": "UniProt", "db_id": "P79374" }, { "db_name": "UniProt", "db_id": "Q06599" }, { "db_name": "UniProt", "db_id": "Q19LH4" }, { "db_name": "UniProt", "db_id": "Q1G1A2" }, { "db_name": "UniProt", "db_id": "Q1WM27" }, { "db_name": "UniProt", "db_id": "Q2MH05" }, { "db_name": "UniProt", "db_id": "Q539C2" }, { "db_name": "UniProt", "db_id": "Q75N23" }, { "db_name": "UniProt", "db_id": "Q8HZD9" }, { "db_name": "UniProt", "db_id": "Q8JFG3" }, { "db_name": "UniProt", "db_id": "Q8MKG8" }, { "db_name": "UniProt", "db_id": "Q8WNR1" }, { "db_name": "UniProt", "db_id": "Q9BEA1" } ] }, { "id": "DS.d279.s2.e3", "type": "protein", "text": [ "IL-6" ], "offsets": [ [ 311, 315 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35736" }, { "db_name": "UniProt", "db_id": "P05231" }, { "db_name": "UniProt", "db_id": "P08505" }, { "db_name": "UniProt", "db_id": "P20607" }, { "db_name": "UniProt", "db_id": "P26892" }, { "db_name": "UniProt", "db_id": "P26893" }, { "db_name": "UniProt", "db_id": "P29455" }, { "db_name": "UniProt", "db_id": "P41323" }, { "db_name": "UniProt", "db_id": "P41683" }, { "db_name": "UniProt", "db_id": "P41693" }, { "db_name": "UniProt", "db_id": "P46650" }, { "db_name": "UniProt", "db_id": "P51494" }, { "db_name": "UniProt", "db_id": "P79341" }, { "db_name": "UniProt", "db_id": "Q25BC2" }, { "db_name": "UniProt", "db_id": "Q28319" }, { "db_name": "UniProt", "db_id": "Q28747" }, { "db_name": "UniProt", "db_id": "Q28819" }, { "db_name": "UniProt", "db_id": "Q2MH06" }, { "db_name": "UniProt", "db_id": "Q5I6E3" }, { "db_name": "UniProt", "db_id": "Q6V919" }, { "db_name": "UniProt", "db_id": "Q865W7" }, { "db_name": "UniProt", "db_id": "Q865X6" }, { "db_name": "UniProt", "db_id": "Q8MKH0" }, { "db_name": "UniProt", "db_id": "Q95181" }, { "db_name": "UniProt", "db_id": "Q9MZR1" }, { "db_name": "UniProt", "db_id": "Q9XT80" } ] }, { "id": "DS.d279.s3.e0", "type": "compound", "text": [ "7-Ketocholesterol" ], "offsets": [ [ 349, 366 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "91474" } ] }, { "id": "DS.d279.s3.e1", "type": "protein", "text": [ "interleukin-6" ], "offsets": [ [ 379, 392 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P41693" } ] }, { "id": "DS.d279.s3.e2", "type": "protein", "text": [ "tumor necrosis factor" ], "offsets": [ [ 440, 461 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q8JFG3" } ] }, { "id": "DS.d279.s4.e0", "type": "protein", "text": [ "IL-6" ], "offsets": [ [ 532, 536 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35736" }, { "db_name": "UniProt", "db_id": "P05231" }, { "db_name": "UniProt", "db_id": "P08505" }, { "db_name": "UniProt", "db_id": "P20607" }, { "db_name": "UniProt", "db_id": "P26892" }, { "db_name": 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[]
[]
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DS.d280
18521540
[ { "id": "DS.d280.s0", "type": "", "text": [ "AGI-1067 is a novel, phenolic antioxidant, and vascular protectant which dose-dependently inhibits PEA biomarkers in vitro." ], "offsets": [ [ 0, 123 ] ] } ]
[ { "id": "DS.d280.s0.e0", "type": "compound", "text": [ "AGI-1067" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "216325" } ] }, { "id": "DS.d280.s0.e1", "type": "protein", "text": [ "PEA" ], "offsets": [ [ 99, 102 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P0C1A8" }, { "db_name": "UniProt", "db_id": "P0C1A9" } ] } ]
[]
[]
[ { "id": "DS.d280.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d280.s0.e0", "arg2_id": "DS.d280.s0.e1", "normalized": [] } ]
DS.d281
18521605
[ { "id": "DS.d281.s0", "type": "", "text": [ "Hydralazine inhibits human cervical cancer cell growth in vitro in association with APC demethylation and re-expression." ], "offsets": [ [ 0, 120 ] ] }, { "id": "DS.d281.s1", "type": "", "text": [ "Clinically, it has been approved that DNA methylation inhibitors, such as 5-aza-2'-deoxycytidine (5-Aza-dC), can reverse APC promoter methylation, but widespread clinical use of these inhibitors is limited by their toxicity and instability in aqueous solution." ], "offsets": [ [ 121, 381 ] ] } ]
[ { "id": "DS.d281.s0.e0", "type": "compound", "text": [ "Hydralazine" ], "offsets": [ [ 0, 11 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3637" } ] }, { "id": "DS.d281.s0.e1", "type": "protein", "text": [ "APC" ], "offsets": [ [ 84, 87 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P25054" } ] }, { "id": "DS.d281.s1.e0", "type": "compound", "text": [ "5-aza-2'-deoxycytidine" ], "offsets": [ [ 195, 217 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "451668" } ] }, { "id": "DS.d281.s1.e1", "type": "compound", "text": [ "5-Aza-dC" ], "offsets": [ [ 219, 227 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "451668" } ] }, { "id": "DS.d281.s1.e2", "type": "protein", "text": [ "APC" ], "offsets": [ [ 242, 245 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P25054" } ] } ]
[]
[]
[ { "id": "DS.d281.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d281.s0.e0", "arg2_id": "DS.d281.s0.e1", "normalized": [] }, { "id": "DS.d281.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d281.s1.e0", "arg2_id": "DS.d281.s1.e2", "normalized": [] }, { "id": "DS.d281.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d281.s1.e1", "arg2_id": "DS.d281.s1.e2", "normalized": [] } ]
DS.d282
18521740
[ { "id": "DS.d282.s1", "type": "", "text": [ "Lastly, we found that the downstream metabolite of 5alpha-dihydrotestosterone, 5alpha- androstane-3beta,17beta-diol (3betaAdiol), is estrogenic in breast cancer cells, and induces growth and ER-signaling via activation of ERalpha." ], "offsets": [ [ 0, 230 ] ] } ]
[ { "id": "DS.d282.s1.e0", "type": "compound", "text": [ "5alpha-dihydrotestosterone" ], "offsets": [ [ 51, 77 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10635" } ] }, { "id": "DS.d282.s1.e2", "type": "protein", "text": [ "ERalpha" ], "offsets": [ [ 222, 229 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42132" }, { "db_name": "UniProt", "db_id": "P03372" }, { "db_name": "UniProt", "db_id": "P06211" }, { "db_name": "UniProt", "db_id": "P06212" }, { "db_name": "UniProt", "db_id": "P16058" }, { "db_name": "UniProt", "db_id": "P19785" }, { "db_name": "UniProt", "db_id": "P49884" }, { "db_name": "UniProt", "db_id": "P49885" }, { "db_name": "UniProt", "db_id": "P49886" }, { "db_name": "UniProt", "db_id": "P50240" }, { "db_name": "UniProt", "db_id": "P50241" }, { "db_name": "UniProt", "db_id": "P50242" }, { "db_name": "UniProt", "db_id": "P57717" }, { "db_name": "UniProt", "db_id": "P57753" }, { "db_name": "UniProt", "db_id": "P81559" }, { "db_name": "UniProt", "db_id": "Q29040" }, { "db_name": "UniProt", "db_id": "Q53AD2" }, { "db_name": "UniProt", "db_id": "Q91250" }, { "db_name": "UniProt", "db_id": "Q91424" }, { "db_name": "UniProt", "db_id": "Q9PVZ9" }, { "db_name": "UniProt", "db_id": "Q9QZJ5" }, { "db_name": "UniProt", "db_id": "Q9TV98" }, { "db_name": "UniProt", "db_id": "Q9YH33" }, { "db_name": "UniProt", "db_id": "Q9YHT3" }, { "db_name": "UniProt", "db_id": "Q9YHZ7" } ] } ]
[]
[]
[ { "id": "DS.d282.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d282.s1.e0", "arg2_id": "DS.d282.s1.e2", "normalized": [] } ]
DS.d283
18521741
[ { "id": "DS.d283.s0", "type": "", "text": [ "Here we demonstrate that an AR ligand, 5-alpha-dihydrotestosterone (DHT), inhibits MCF-7 breast cancer cell growth induced by insulin like growth factor 1 (IGF-I)." ], "offsets": [ [ 0, 163 ] ] } ]
[ { "id": "DS.d283.s0.e0", "type": "compound", "text": [ "5-alpha-dihydrotestosterone" ], "offsets": [ [ 39, 66 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "15" }, { "db_name": "PubChem", "db_id": "10635" } ] }, { "id": "DS.d283.s0.e1", "type": "compound", "text": [ "DHT" ], "offsets": [ [ 68, 71 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10635" } ] }, { "id": "DS.d283.s0.e3", "type": "protein", "text": [ "IGF-I" ], "offsets": [ [ 156, 161 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05017" }, { "db_name": "UniProt", "db_id": "P07455" }, { "db_name": "UniProt", "db_id": "P08025" }, { "db_name": "UniProt", "db_id": "P10763" }, { "db_name": "UniProt", "db_id": "P16545" }, { "db_name": "UniProt", "db_id": "P17085" }, { "db_name": "UniProt", "db_id": "P17647" }, { "db_name": "UniProt", "db_id": "P18254" }, { "db_name": "UniProt", "db_id": "P33712" }, { "db_name": "UniProt", "db_id": "P51457" }, { "db_name": "UniProt", "db_id": "P51458" }, { "db_name": "UniProt", "db_id": "P51462" }, { "db_name": "UniProt", "db_id": "Q02815" }, { "db_name": "UniProt", "db_id": "Q28933" }, { "db_name": "UniProt", "db_id": "Q68LC0" }, { "db_name": "UniProt", "db_id": "Q6GUL6" }, { "db_name": "UniProt", "db_id": "Q6IVA5" }, { "db_name": "UniProt", "db_id": "Q6JLX1" }, { "db_name": "UniProt", "db_id": "Q95222" } ] } ]
[]
[]
[ { "id": "DS.d283.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d283.s0.e0", "arg2_id": "DS.d283.s0.e3", "normalized": [] }, { "id": "DS.d283.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d283.s0.e1", "arg2_id": "DS.d283.s0.e3", "normalized": [] } ]
DS.d284
18521748
[ { "id": "DS.d284.s0", "type": "", "text": [ "Here, we constructed variants to test whether any of these motifs may explain why TRPM2-DeltaN does not respond to stimulation with either ADP ribose or hydrogen peroxide." ], "offsets": [ [ 0, 171 ] ] } ]
[ { "id": "DS.d284.s0.e0", "type": "protein", "text": [ "TRPM2" ], "offsets": [ [ 82, 87 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O94759" } ] }, { "id": "DS.d284.s0.e1", "type": "compound", "text": [ "hydrogen peroxide" ], "offsets": [ [ 153, 170 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "784" } ] } ]
[]
[]
[]
DS.d285
18521846
[ { "id": "DS.d285.s0", "type": "", "text": [ "We found that 2-methoxyestradiol induced the activation of JNK, ERK, and p38 MAPKs." ], "offsets": [ [ 0, 83 ] ] }, { "id": "DS.d285.s1", "type": "", "text": [ "2-methoxyestradiol-induced JNK activation was associated with the induction of apoptosis through the mitochondrial pathways as a result of increased phosphorylation (inactivation) of the anti-apoptotic Bcl-2 and Bcl-xL proteins." ], "offsets": [ [ 84, 312 ] ] }, { "id": "DS.d285.s2", "type": "", "text": [ "In comparison, 2-methoxyestradiol-induced activation of ERK and p38 in these cells was found to have a protective effect against 2-MeO-E(2)-induced apoptosis." ], "offsets": [ [ 313, 471 ] ] }, { "id": "DS.d285.s3", "type": "", "text": [ "Mechanistically, inhibition of ERK and p38 activity was associated with activation of various caspases and PARP cleavage, and it also stabilized the pro-apoptotic proteins Bax and Bim, thereby preventing them from degradation during 2-methoxyestradiol treatment." ], "offsets": [ [ 472, 734 ] ] } ]
[ { "id": "DS.d285.s0.e0", "type": "compound", "text": [ "2-methoxyestradiol" ], "offsets": [ [ 14, 32 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "66414" } ] }, { "id": "DS.d285.s0.e1", "type": "protein", "text": [ "JNK" ], "offsets": [ [ 59, 62 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P92208" }, { "db_name": "UniProt", "db_id": "Q966Y3" } ] }, { "id": "DS.d285.s0.e2", "type": "protein", "text": [ "ERK" ], "offsets": [ [ 64, 67 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P29323" } ] }, { "id": "DS.d285.s0.e3", "type": "protein", "text": [ "p38 MAPKs" ], "offsets": [ [ 73, 82 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62618" } ] }, { "id": "DS.d285.s1.e0", "type": "compound", "text": [ "2-methoxyestradiol" ], "offsets": [ [ 84, 102 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "66414" } ] }, { "id": "DS.d285.s1.e1", "type": "protein", "text": [ "JNK" ], "offsets": [ [ 111, 114 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P92208" }, { "db_name": "UniProt", "db_id": "Q966Y3" } ] }, { "id": "DS.d285.s1.e2", "type": "protein", "text": [ "Bcl-2" ], "offsets": [ [ 286, 291 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10417" }, { "db_name": "UniProt", "db_id": "P49950" } ] }, { "id": "DS.d285.s2.e0", "type": "compound", "text": [ "2-methoxyestradiol" ], "offsets": [ [ 328, 346 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "66414" } ] }, { "id": "DS.d285.s2.e1", "type": "protein", "text": [ "ERK" ], "offsets": [ [ 369, 372 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P29323" } ] }, { "id": "DS.d285.s2.e2", "type": "protein", "text": [ "p38" ], "offsets": [ [ 377, 380 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O24473" }, { "db_name": "UniProt", "db_id": "O75791" }, { "db_name": "UniProt", "db_id": "O95433" }, { "db_name": "UniProt", "db_id": "O97628" }, { "db_name": "UniProt", "db_id": "P46108" }, { "db_name": "UniProt", "db_id": "P80350" }, { "db_name": "UniProt", "db_id": "P82869" }, { "db_name": "UniProt", "db_id": "Q01552" }, { "db_name": "UniProt", "db_id": "Q04929" }, { "db_name": "UniProt", "db_id": "Q63768" }, { "db_name": "UniProt", "db_id": "Q64010" }, { "db_name": "UniProt", "db_id": "Q9LDA4" }, { "db_name": "UniProt", "db_id": "Q9Y2S7" } ] }, { "id": "DS.d285.s3.e0", "type": "protein", "text": [ "ERK" ], "offsets": [ [ 503, 506 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P29323" } ] }, { "id": "DS.d285.s3.e1", "type": "protein", "text": [ "p38" ], "offsets": [ [ 511, 514 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O24473" }, { "db_name": "UniProt", "db_id": "O75791" }, { "db_name": "UniProt", "db_id": "O95433" }, { "db_name": "UniProt", "db_id": "O97628" }, { "db_name": "UniProt", "db_id": "P46108" }, { "db_name": "UniProt", "db_id": "P80350" }, { "db_name": "UniProt", "db_id": "P82869" }, { "db_name": "UniProt", "db_id": "Q01552" }, { "db_name": "UniProt", "db_id": "Q04929" }, { "db_name": "UniProt", "db_id": "Q63768" }, { "db_name": "UniProt", "db_id": "Q64010" }, { "db_name": "UniProt", "db_id": "Q9LDA4" }, { "db_name": "UniProt", "db_id": "Q9Y2S7" } ] }, { "id": "DS.d285.s3.e2", "type": "protein", "text": [ "PARP" ], "offsets": [ [ 579, 583 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O50017" }, { "db_name": "UniProt", "db_id": "P08469" }, { "db_name": "UniProt", "db_id": "P14043" }, { "db_name": "UniProt", "db_id": "P31669" }, { "db_name": "UniProt", "db_id": "P35875" }, { "db_name": "UniProt", "db_id": "P55057" }, { "db_name": "UniProt", "db_id": "Q08824" }, { "db_name": "UniProt", "db_id": "Q11208" } ] }, { "id": "DS.d285.s3.e3", "type": "protein", "text": [ "proteins Bax" ], "offsets": [ [ 635, 647 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27297" } ] }, { "id": "DS.d285.s3.e4", "type": "protein", "text": [ "Bim" ], "offsets": [ [ 652, 655 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O54918" }, { "db_name": "UniProt", "db_id": "O88498" } ] }, { "id": "DS.d285.s3.e5", "type": "compound", "text": [ "2-methoxyestradiol" ], "offsets": [ [ 705, 723 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "66414" } ] } ]
[]
[]
[ { "id": "DS.d285.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d285.s0.e0", "arg2_id": "DS.d285.s0.e2", "normalized": [] }, { "id": "DS.d285.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d285.s0.e0", "arg2_id": "DS.d285.s0.e3", "normalized": [] }, { "id": "DS.d285.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d285.s0.e0", "arg2_id": "DS.d285.s0.e1", "normalized": [] }, { "id": "DS.d285.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d285.s1.e0", "arg2_id": "DS.d285.s1.e2", "normalized": [] }, { "id": "DS.d285.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d285.s1.e0", "arg2_id": "DS.d285.s1.e1", "normalized": [] }, { "id": "DS.d285.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d285.s2.e0", "arg2_id": "DS.d285.s2.e1", "normalized": [] }, { "id": "DS.d285.s2.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d285.s2.e0", "arg2_id": "DS.d285.s2.e2", "normalized": [] } ]
DS.d286
18521859
[ { "id": "DS.d286.s0", "type": "", "text": [ "Accumulating evidence suggests that phosphatidylinositol (PI) pathways have been involved in the secretion of dopamine (DA) and the regulation of DA transporter, which is a target of methamphetamine (METH)." ], "offsets": [ [ 0, 206 ] ] } ]
[ { "id": "DS.d286.s0.e0", "type": "compound", "text": [ "phosphatidylinositol" ], "offsets": [ [ 36, 56 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "53477912" } ] }, { "id": "DS.d286.s0.e1", "type": "compound", "text": [ "dopamine" ], "offsets": [ [ 110, 118 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "681" } ] }, { "id": "DS.d286.s0.e2", "type": "protein", "text": [ "DA transporter" ], "offsets": [ [ 146, 160 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P23977" }, { "db_name": "UniProt", "db_id": "P27922" }, { "db_name": "UniProt", "db_id": "Q01959" }, { "db_name": "UniProt", "db_id": "Q03614" }, { "db_name": "UniProt", "db_id": "Q61327" }, { "db_name": "UniProt", "db_id": "Q9GJT6" } ] }, { "id": "DS.d286.s0.e3", "type": "compound", "text": [ "methamphetamine" ], "offsets": [ [ 183, 198 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1206" }, { "db_name": "PubChem", "db_id": "10836" }, { "db_name": "PubChem", "db_id": "36604" } ] } ]
[]
[]
[ { "id": "DS.d286.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d286.s0.e3", "arg2_id": "DS.d286.s0.e2", "normalized": [] }, { "id": "DS.d286.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d286.s0.e0", "arg2_id": "DS.d286.s0.e2", "normalized": [] } ]
DS.d287
18522674
[ { "id": "DS.d287.s0", "type": "", "text": [ "Celecoxib caused a 60% reduction in testicular interstitial fluid (IF) prostaglandin E(2) (PGE (2)) concentrations, accompanied by a compensatory increase in COX-2 mRNA expression." ], "offsets": [ [ 0, 180 ] ] }, { "id": "DS.d287.s1", "type": "", "text": [ "However, celecoxib had no effect on COX-2 protein levels or LPS-induced expression of the inflammatory mediators interleukin-1beta, tumour necrosis factor-alpha or inducible nitric-oxide synthase." ], "offsets": [ [ 181, 377 ] ] }, { "id": "DS.d287.s2", "type": "", "text": [ "These data indicate that celecoxib reduces intratesticular activity of COX-2 (as indicated by PGE (2) levels) and inhibits IF formation in the testis, but has no appreciable effect on steroidogenesis or spermatogenesis, at least in the short term." ], "offsets": [ [ 378, 625 ] ] }, { "id": "DS.d287.s3", "type": "", "text": [ "These results indicate significant roles for products of the COX-2 pathway in testicular vascular control and steroidogenesis, which may have implications for men with marginal fertility taking celecoxib for extended periods, but also highlight the potential of this drug to ameliorate testicular damage caused by systemic or local inflammation." ], "offsets": [ [ 626, 971 ] ] } ]
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[]
[]
[ { "id": "DS.d287.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d287.s0.e0", "arg2_id": "DS.d287.s0.e2", "normalized": [] }, { "id": "DS.d287.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d287.s0.e0", "arg2_id": "DS.d287.s0.e1", "normalized": [] }, { "id": "DS.d287.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d287.s2.e0", "arg2_id": "DS.d287.s2.e1", "normalized": [] }, { "id": "DS.d287.s2.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d287.s2.e0", "arg2_id": "DS.d287.s2.e2", "normalized": [] }, { "id": "DS.d287.s3.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d287.s3.e1", "arg2_id": "DS.d287.s3.e0", "normalized": [] } ]
DS.d288
18528683
[ { "id": "DS.d288.s0", "type": "", "text": [ "At the end of the experiment (after 6 weeks), lung histological changes, collagen staining, the activity of glutathione reductase (GR) and contents of reduced glutathione (GSH) and hydroxyproline (Hpr) in the lung as well as serum level of tumor necrosis factor-alpha (TNF-alpha) were evaluated." ], "offsets": [ [ 0, 295 ] ] }, { "id": "DS.d288.s1", "type": "", "text": [ "The obtained data revealed that BCNU induced pathological changes and markedly increased lung collagen and level of Hpr but decreased GSH content and GR activity and increased serum TNF-alpha compared to both control and MT-administered rats." ], "offsets": [ [ 296, 538 ] ] } ]
[ { "id": "DS.d288.s0.e0", "type": "protein", "text": [ "glutathione reductase" ], "offsets": [ [ 108, 129 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O15770" }, { "db_name": "UniProt", "db_id": "P06715" }, { "db_name": "UniProt", "db_id": "P11804" }, { "db_name": "UniProt", "db_id": "P23189" }, { "db_name": "UniProt", "db_id": "P41921" }, { "db_name": "UniProt", "db_id": "P43783" }, { "db_name": "UniProt", "db_id": "P48638" }, { "db_name": "UniProt", "db_id": "P48639" }, { "db_name": "UniProt", "db_id": "P70619" }, { "db_name": "UniProt", "db_id": "P78965" }, { "db_name": "UniProt", "db_id": "Q60151" }, { "db_name": "UniProt", "db_id": "Q6BPI1" }, { "db_name": "UniProt", "db_id": "Q6C5H4" }, { "db_name": "UniProt", "db_id": "Q6FRV2" }, { "db_name": "UniProt", "db_id": "Q6HA23" }, { "db_name": "UniProt", "db_id": "Q74ZK4" }, { "db_name": "UniProt", "db_id": "Q873E8" }, { "db_name": "UniProt", "db_id": "Q94655" } ] }, { "id": "DS.d288.s0.e1", "type": "compound", "text": [ "reduced glutathione" ], "offsets": [ [ 151, 170 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d288.s0.e2", "type": "compound", "text": [ "GSH" ], "offsets": [ [ 172, 175 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d288.s0.e3", "type": "compound", "text": [ "hydroxyproline" ], "offsets": [ [ 181, 195 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "825" }, { "db_name": "PubChem", "db_id": "5810" }, { "db_name": "PubChem", "db_id": "69248" }, { "db_name": "PubChem", "db_id": "440015" } ] }, { "id": "DS.d288.s0.e4", "type": "protein", "text": [ "tumor necrosis factor" ], "offsets": [ [ 240, 261 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q8JFG3" } ] }, { "id": "DS.d288.s0.e5", "type": "protein", "text": [ "TNF-alpha" ], "offsets": [ [ 269, 278 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35734" }, { "db_name": "UniProt", "db_id": "O77510" }, { "db_name": "UniProt", "db_id": "O77764" }, { "db_name": "UniProt", "db_id": "P01375" }, { "db_name": "UniProt", "db_id": "P04924" }, { "db_name": "UniProt", "db_id": "P06804" }, { "db_name": "UniProt", "db_id": "P13296" }, { "db_name": "UniProt", "db_id": "P16599" }, { "db_name": "UniProt", "db_id": "P19101" }, { "db_name": "UniProt", "db_id": "P23383" }, { "db_name": "UniProt", "db_id": "P23563" }, { "db_name": "UniProt", "db_id": "P29553" }, { "db_name": "UniProt", "db_id": "P33620" }, { "db_name": "UniProt", "db_id": "P36939" }, { "db_name": "UniProt", "db_id": "P48094" }, { "db_name": "UniProt", "db_id": "P51435" }, { "db_name": "UniProt", "db_id": "P51742" }, { "db_name": "UniProt", "db_id": "P51743" }, { "db_name": "UniProt", "db_id": "P59684" }, { "db_name": "UniProt", "db_id": "P59693" }, { "db_name": "UniProt", "db_id": "P59694" }, { "db_name": "UniProt", "db_id": "P59695" }, { "db_name": "UniProt", "db_id": "P79337" }, { "db_name": "UniProt", "db_id": "P79374" }, { "db_name": "UniProt", "db_id": "Q06599" }, { "db_name": "UniProt", "db_id": "Q19LH4" }, { "db_name": "UniProt", "db_id": "Q1G1A2" }, { "db_name": "UniProt", "db_id": "Q1WM27" }, { "db_name": "UniProt", "db_id": "Q2MH05" }, { "db_name": "UniProt", "db_id": "Q539C2" }, { "db_name": "UniProt", "db_id": "Q75N23" }, { "db_name": "UniProt", "db_id": "Q8HZD9" }, { "db_name": "UniProt", "db_id": "Q8JFG3" }, { "db_name": "UniProt", "db_id": "Q8MKG8" }, { "db_name": "UniProt", "db_id": "Q8WNR1" }, { "db_name": "UniProt", "db_id": "Q9BEA1" } ] }, { "id": "DS.d288.s1.e0", "type": "compound", "text": [ "BCNU" ], "offsets": [ [ 328, 332 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2578" } ] }, { "id": "DS.d288.s1.e1", "type": "protein", "text": [ "Hpr" ], "offsets": [ [ 412, 415 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P0AA04" }, { "db_name": "UniProt", "db_id": "P0AA07" }, { "db_name": "UniProt", "db_id": "P11065" }, { "db_name": "UniProt", "db_id": "P77335" } ] }, { "id": "DS.d288.s1.e2", "type": "compound", "text": [ "GSH" ], "offsets": [ [ 430, 433 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d288.s1.e3", "type": "protein", "text": [ "TNF-alpha" ], "offsets": [ [ 478, 487 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35734" }, { "db_name": "UniProt", "db_id": "O77510" }, { "db_name": "UniProt", "db_id": "O77764" }, { "db_name": "UniProt", "db_id": "P01375" }, { "db_name": "UniProt", "db_id": "P04924" }, { "db_name": "UniProt", "db_id": "P06804" }, { "db_name": "UniProt", "db_id": "P13296" }, { "db_name": "UniProt", "db_id": "P16599" }, { "db_name": "UniProt", "db_id": "P19101" }, { "db_name": "UniProt", "db_id": "P23383" }, { "db_name": "UniProt", "db_id": "P23563" }, { "db_name": "UniProt", "db_id": "P29553" }, { "db_name": "UniProt", "db_id": "P33620" }, { "db_name": "UniProt", "db_id": "P36939" }, { "db_name": "UniProt", "db_id": "P48094" }, { "db_name": "UniProt", "db_id": "P51435" }, { "db_name": "UniProt", "db_id": "P51742" }, { "db_name": "UniProt", "db_id": "P51743" }, { "db_name": "UniProt", "db_id": "P59684" }, { "db_name": "UniProt", "db_id": "P59693" }, { "db_name": "UniProt", "db_id": "P59694" }, { "db_name": "UniProt", "db_id": "P59695" }, { "db_name": "UniProt", "db_id": "P79337" }, { "db_name": "UniProt", "db_id": "P79374" }, { "db_name": "UniProt", "db_id": "Q06599" }, { "db_name": "UniProt", "db_id": "Q19LH4" }, { "db_name": "UniProt", "db_id": "Q1G1A2" }, { "db_name": "UniProt", "db_id": "Q1WM27" }, { "db_name": "UniProt", "db_id": "Q2MH05" }, { "db_name": "UniProt", "db_id": "Q539C2" }, { "db_name": "UniProt", "db_id": "Q75N23" }, { "db_name": "UniProt", "db_id": "Q8HZD9" }, { "db_name": "UniProt", "db_id": "Q8JFG3" }, { "db_name": "UniProt", "db_id": "Q8MKG8" }, { "db_name": "UniProt", "db_id": "Q8WNR1" }, { "db_name": "UniProt", "db_id": "Q9BEA1" } ] } ]
[]
[]
[ { "id": "DS.d288.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d288.s1.e0", "arg2_id": "DS.d288.s1.e1", "normalized": [] }, { "id": "DS.d288.s1.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d288.s1.e0", "arg2_id": "DS.d288.s1.e3", "normalized": [] } ]
DS.d289
18528747
[ { "id": "DS.d289.s0", "type": "", "text": [ "Collectively, HMB supplementation increased concentrations of short-chain fatty acids in intestinal lumen, expression of proglucagon, GLP-2R, and eNOS genes, and net portal absorption of AA." ], "offsets": [ [ 0, 190 ] ] } ]
[ { "id": "DS.d289.s0.e0", "type": "protein", "text": [ "HMB" ], "offsets": [ [ 14, 17 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P06116" } ] }, { "id": "DS.d289.s0.e1", "type": "compound", "text": [ "short-chain fatty acids" ], "offsets": [ [ 62, 85 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "176" } ] }, { "id": "DS.d289.s0.e2", "type": "protein", "text": [ "GLP-2R" ], "offsets": [ [ 134, 140 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O95838" }, { "db_name": "UniProt", "db_id": "Q9Z0W0" } ] }, { "id": "DS.d289.s0.e3", "type": "protein", "text": [ "eNOS" ], "offsets": [ [ 146, 150 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P29473" }, { "db_name": "UniProt", "db_id": "P29474" }, { "db_name": "UniProt", "db_id": "P70313" }, { "db_name": "UniProt", "db_id": "P79209" }, { "db_name": "UniProt", "db_id": "P97270" }, { "db_name": "UniProt", "db_id": "Q28969" }, { "db_name": "UniProt", "db_id": "Q62600" } ] } ]
[]
[]
[ { "id": "DS.d289.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d289.s0.e1", "arg2_id": "DS.d289.s0.e0", "normalized": [] } ]
DS.d290
18528783
[ { "id": "DS.d290.s0", "type": "", "text": [ "In search for the pharmacophore and to analyze structure-activity relationships we synthesized a series of truncated derivatives and analogs of RB-2, including 1-amino-2-sulfo-4-ar(alk)ylaminoanthraquinones, 1-amino-2-methyl-4-arylaminoanthraquinones, 1-amino-4-bromoanthraquinone 2-sulfonic acid esters and sulfonamides, and bis-(1-amino-4-bromoanthraquinone) sulfonamides, and investigated them in preparations of rat NTPDase1, 2, and 3 using a capillary electrophoresis assay." ], "offsets": [ [ 0, 479 ] ] } ]
[ { "id": "DS.d290.s0.e0", "type": "compound", "text": [ "RB-2" ], "offsets": [ [ 144, 148 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "656725" } ] }, { "id": "DS.d290.s0.e1", "type": "compound", "text": [ "1-amino-4-bromoanthraquinone 2-sulfonic acid" ], "offsets": [ [ 252, 296 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "22628" } ] }, { "id": "DS.d290.s0.e2", "type": "protein", "text": [ "NTPDase1" ], "offsets": [ [ 420, 428 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18956" }, { "db_name": "UniProt", "db_id": "O93295" }, { "db_name": "UniProt", "db_id": "P49961" }, { "db_name": "UniProt", "db_id": "P55772" }, { "db_name": "UniProt", "db_id": "P97687" }, { "db_name": "UniProt", "db_id": "Q9MYU4" } ] } ]
[]
[]
[]
DS.d291
18533896
[ { "id": "DS.d291.s0", "type": "", "text": [ "Plasma insulin 0.05) following ingestion of GluF than after Glu alone, without any differences between the effects of either intervention on plasma glucose concentrations." ], "offsets": [ [ 0, 171 ] ] } ]
[ { "id": "DS.d291.s0.e0", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 7, 14 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d291.s0.e1", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 148, 155 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] } ]
[]
[]
[]
DS.d292
18534791
[ { "id": "DS.d292.s0", "type": "", "text": [ "No significant differences were observed in plasma concentrations of glucose, NEFA, and insulin-like growth factor or hepatic triglyceride content, but all supplements tended to decrease beta hydroxybutyrate postpartum compared to CTL cows." ], "offsets": [ [ 0, 240 ] ] } ]
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[]
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DS.d293
18534811
[ { "id": "DS.d293.s0", "type": "", "text": [ "The results showed that colchicine augmented splenic-specific IgG1 and IL-4 as well as cell proliferation but suppressed specific IgG2a and IFN-gamma levels." ], "offsets": [ [ 0, 157 ] ] } ]
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DS.d294
18534874
[ { "id": "DS.d294.s0", "type": "", "text": [ "Sunitinib malate (Pfizer, Inc.) is a multitargeted kinase inhibitor that inhibits vascular endothelial growth factor (VEGF) receptor (R)-1, 2 and 3, platelet-derived growth factor receptors (PDGFR)-alpha and beta, Flt3, RET, and Kit." ], "offsets": [ [ 0, 233 ] ] } ]
[ { "id": "DS.d294.s0.e0", "type": "compound", "text": [ "Sunitinib malate" ], "offsets": [ [ 0, 16 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5329102" } ] }, { "id": "DS.d294.s0.e1", "type": "protein", "text": [ "VEGF" ], "offsets": [ [ 118, 122 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15691" }, { "db_name": "UniProt", "db_id": "P15692" }, { "db_name": "UniProt", "db_id": "P26617" }, { "db_name": "UniProt", "db_id": "P49151" }, { "db_name": "UniProt", "db_id": "P50412" }, { "db_name": "UniProt", "db_id": "P67964" }, { "db_name": "UniProt", "db_id": "P67965" }, { "db_name": "UniProt", "db_id": "Q99PS1" }, { "db_name": "UniProt", "db_id": "Q9GKR0" }, { "db_name": "UniProt", "db_id": "Q9MYV3" } ] }, { "id": "DS.d294.s0.e2", "type": "protein", "text": [ "Flt3" ], "offsets": [ [ 214, 218 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q00342" } ] }, { "id": "DS.d294.s0.e3", "type": "protein", "text": [ "RET" ], "offsets": [ [ 220, 223 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P07949" } ] } ]
[]
[]
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DS.d295
18536700
[ { "id": "DS.d295.s0", "type": "", "text": [ "Narp deletion blocks extinction of morphine place preference conditioning." ], "offsets": [ [ 0, 74 ] ] }, { "id": "DS.d295.s1", "type": "", "text": [ "Accordingly, to assess its potential role in the long-lasting behavioral effects of drugs of abuse, we have investigated the impact of Narp deletion on sustained behavioral responses elicited by repeated morphine administration." ], "offsets": [ [ 75, 303 ] ] } ]
[ { "id": "DS.d295.s0.e0", "type": "protein", "text": [ "Narp" ], "offsets": [ [ 0, 4 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P97738" } ] }, { "id": "DS.d295.s0.e1", "type": "compound", "text": [ "morphine" ], "offsets": [ [ 35, 43 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5288826" }, { "db_name": "PubChem", "db_id": "5479215" } ] }, { "id": "DS.d295.s1.e0", "type": "protein", "text": [ "Narp" ], "offsets": [ [ 210, 214 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P97738" } ] }, { "id": "DS.d295.s1.e1", "type": "compound", "text": [ "morphine" ], "offsets": [ [ 279, 287 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5288826" }, { "db_name": "PubChem", "db_id": "5479215" } ] } ]
[]
[]
[ { "id": "DS.d295.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d295.s0.e1", "arg2_id": "DS.d295.s0.e0", "normalized": [] } ]
DS.d296
18536704
[ { "id": "DS.d296.s0", "type": "", "text": [ "Decreased dopamine D4 receptor expression increases extracellular glutamate and alters its regulation in mouse striatum." ], "offsets": [ [ 0, 120 ] ] } ]
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[]
[]
[ { "id": "DS.d296.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d296.s0.e1", "arg2_id": "DS.d296.s0.e0", "normalized": [] } ]
DS.d297
18536705
[ { "id": "DS.d297.s0", "type": "", "text": [ "injection of PACAP provoked a significant increase in plasma glucose level." ], "offsets": [ [ 0, 75 ] ] } ]
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[]
[]
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DS.d298
18536954
[ { "id": "DS.d298.s0", "type": "", "text": [ "In 17 adults on a fixed metabolic diet, an 11-day course of cinacalcet increased serum gastrin and basal gastric acid output, but not maximal gastric acid output, compared with a placebo." ], "offsets": [ [ 0, 187 ] ] } ]
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[]
[]
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DS.d299
18537150
[ { "id": "DS.d299.s0", "type": "", "text": [ "Since PSC-833 was found to be a weak inhibitor of CYP 3A4 and to have no inhibitory effects on esterases, phenol sulfotransferases, and glucuronyltransferases, it is suggested PSC-833 enhances intestinal mucosal permeation of these cyclic prodrugs by inhibiting their polarized efflux and not by inhibiting their metabolism." ], "offsets": [ [ 0, 324 ] ] } ]
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[]
[]
[]
DS.d300
18538372
[ { "id": "DS.d300.s0", "type": "", "text": [ "We showed that after treatment of HCT116 cells with a low dose of doxorubicin most of them stopped proliferation as documented by SA-beta-galactosidase activity and the lack of Ki67 expression." ], "offsets": [ [ 0, 193 ] ] } ]
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[]
[]
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DS.d302
18539357
[ { "id": "DS.d302.s0", "type": "", "text": [ "Tumor MUC1 differs from normal MUC1 by modified glycan side chains." ], "offsets": [ [ 0, 67 ] ] } ]
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