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split_0_train_400 | split_0_train_400 | [
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"These results confirm that contrast enhancement can significantly improve the quality of Doppler examination and colour - coded duplex sonography of both the intracranial and extracranial vessels ."
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] | [] | [] | [] | [] |
split_0_train_401 | split_0_train_401 | [
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"However , the use of Albunex in neurosonology will be of limited value due to its relatively short duration ."
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109
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] | [] | [] | [] | [] |
split_0_train_402 | split_0_train_402 | [
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"Vancomycin - resistant Enterococcus in liver transplant patients ."
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66
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split_0_train_403 | split_0_train_403 | [
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"BACKGROUND :"
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split_0_train_404 | split_0_train_404 | [
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"text": [
"Vancomycin - resistant Enterococcus ( VRE ) infection is emerging in the transplant population , and there is no effective antibiotic therapy available ."
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0,
153
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] | [] | [] | [] | [] |
split_0_train_405 | split_0_train_405 | [
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"The aims of this retrospective review were to (1) investigate the outcome of and (2) identify common characteristics associated with VRE infection and colonization in orthotopic liver transplant ( OLTx ) candidates ."
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0,
216
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split_0_train_406 | split_0_train_406 | [
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"text": [
"METHODS :"
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9
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split_0_train_407 | split_0_train_407 | [
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"From October 1994 through September 1998 , 126 isolates of VRE were identified in 42 of 234 OLTx recipients and 5 OLTx candidates who did not proceed to transplantation ."
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0,
170
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}
] | [] | [] | [] | [] |
split_0_train_408 | split_0_train_408 | [
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"Data were collected by patient chart review or from a computerized hospital database ."
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] | [] | [] | [] | [] |
split_0_train_409 | split_0_train_409 | [
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"RESULTS :"
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9
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split_0_train_410 | split_0_train_410 | [
{
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"The 1 - year mortality rate with VRE infection was 82 % , and with VRE colonization , 7 % ."
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0,
91
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}
] | [] | [] | [] | [] |
split_0_train_411 | split_0_train_411 | [
{
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"text": [
"This mortality rate contrasts with a 14 % 1 - year mortality for non - VRE transplant patients ( P < 0.01 , infected patients and colonized patients ) ."
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152
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split_0_train_412 | split_0_train_412 | [
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"Characteristics of VRE colonized and infected patients included recent prior vancomycin ( 87 % ) , coinfection by other microbial pathogens ( 74 % ) , recent prior susceptible enterococcal infection ( 72 % ) , concurrent fungal infection ( 62 % ) , additional post - OLTx laparotomies ( 47 % ) , and renal failure ( Cr > 2.5 mg / dL or need for dialysis ; 43 % ) ."
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] | [] | [] | [] | [] |
split_0_train_413 | split_0_train_413 | [
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"text": [
"Biliary complications were seen in 52 % of post - OLTx VRE - infected or VRE-colonized patients ( versus 22 % in non - VRE transplant patients , P < 0.05 ) ."
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157
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split_0_train_414 | split_0_train_414 | [
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"text": [
"CONCLUSION :"
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split_0_train_415 | split_0_train_415 | [
{
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"VRE infection is associated with a very high mortality rate after liver transplantation ."
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split_0_train_416 | split_0_train_416 | [
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"The incidence of biliary complications prior to VRE isolation is very high in VRE - infected and VRE-colonized patients ."
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121
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] | [] | [] | [] | [] |
split_0_train_417 | split_0_train_417 | [
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"text": [
"The most common characteristics of VRE patients were recent prior vancomycin use , recent prior susceptible enterococcal infection , coinfection with other microbial pathogens , and concurrent fungal infection ."
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211
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split_0_train_418 | split_0_train_418 | [
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"With no proven effective antimicrobial therapy for VRE , stringent infection control measures , including strict and limited use of vancomycin , must be practiced ."
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164
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] | [] | [] | [] | [] |
split_0_train_419 | split_0_train_419 | [
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"text": [
"Tracking oxygen effects on MR signal in blood and skeletal muscle during hyperoxia exposure ."
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93
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split_0_train_420 | split_0_train_420 | [
{
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"text": [
"Blood and muscle T1 and T2 relaxivity was examined under normoxic ( air ; 20.8 % O2 ) and hyperoxic ( 100 % O2 ) conditions to determine whether the oxygenation state of blood in the large vessels and in the microcirculation can be monitored in vivo ."
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split_0_train_421 | split_0_train_421 | [
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"text": [
"The femoral artery / vein and the soleus and gastrocnemius muscles were examined in healthy human male volunteers ."
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0,
115
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] | [] | [] | [] | [] |
split_0_train_422 | split_0_train_422 | [
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"text": [
"Arterial blood T1 decreased with hyperoxia , while venous blood T2 increased , due to increased dissolved O2 and decreased deoxyhemoglobin , respectively ."
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"deoxyhemoglobin"
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123,
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split_0_train_423 | split_0_train_423 | [
{
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"text": [
"A biexponential T2 model of muscle is proposed , where the short T2 component reflects primarily the intracellular and interstitial compartments ( in fast exchange ) , and the long T2 reflects blood ."
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0,
200
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split_0_train_424 | split_0_train_424 | [
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"text": [
"In this model , the long T2 component increased with hyperoxia exposure ."
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73
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split_0_train_425 | split_0_train_425 | [
{
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"This was more evident in slow twitch ( soleus ) than in fast twitch ( gastrocnemius ) muscle ."
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94
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split_0_train_426 | split_0_train_426 | [
{
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"It is concluded that changes in the long T2 component reflect change in the microcirculation oxygenation state ."
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0,
112
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] | [] | [] | [] | [] |
split_0_train_427 | split_0_train_427 | [
{
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"text": [
"A study of the renal sodium excretion during the normal menstrual cycle using method of passive leg rising ."
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108
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}
] | [] | [] | [] | [] |
split_0_train_428 | split_0_train_428 | [
{
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"text": [
"12 healthy women ( age 18 - 38 years ) were examined using the 2-hour's method of passive leg rising ( PLR ) in follicular ( FP ) and luteal ( LP ) phases of normal ovulatory cycle ."
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0,
182
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split_0_train_429 | split_0_train_429 | [
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"Renal and hormonal response to PLR was investigated ."
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53
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split_0_train_430 | split_0_train_430 | [
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"There was a significant increase of diuresis ( from 53 +/- 9 ml / h to 298 +/- 27 ml / h in FP , from 69 +/- 12 to 324 +/- 28 ml / h in LP ) and natriuresis ( from 4.5 +/- 0.9 to 9.8 +/- 1 mmol / h in FP , from 5.7 +/- 0.3 to 12.1 +/- 1.1 mmol / h in LP ) , simultaneously with a decrease of plasma renin activity ( PRA ) and plasma aldosterone ( PA ) in both FP and LP ."
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299,
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split_0_train_431 | split_0_train_431 | [
{
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"text": [
"Baseline PRA was mildly and PA was significantly higher in LP compared to FP ."
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0,
78
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split_0_train_432 | split_0_train_432 | [
{
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"Urinary osmolarity , heart rate and systolic blood pressure dropped significantly ."
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83
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split_0_train_433 | split_0_train_433 | [
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"Renal and hormonal response to PLR were identical in the two phases of the menstrual cycle ."
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92
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split_0_train_434 | split_0_train_434 | [
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"text": [
"Authors conclude that 1/PLR causes significant diuresis and natriuresis due to central volume expansion and may be used as a simple stimulating test of renal sodium excretion , 2 / renal sodium retention does not occur in the LP of normal ovulatory cycle ."
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split_0_train_435 | split_0_train_435 | [
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"Identification and structure of the Marek 's disease virus serotype 2 glycoprotein M gene : comparison with glycoprotein M genes of Herpesviridae family ."
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split_0_train_436 | split_0_train_436 | [
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"text": [
"We determined the nucleotide sequence of a portion of BamHI - C fragment of Marek 's disease virus serotype 2 ( MDV2 ) strain HPRS24 which was suspected to contain the homologue of the herpes simplex virus type 1 ( HSV-1 ) gene UL10 , encoding glycoprotein M ( gM ) ."
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"gM"
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261,
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] | [] | [] | [] |
split_0_train_437 | split_0_train_437 | [
{
"id": "split_0_train_437_passage",
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"text": [
"An open reading frame whose translation product exhibited significant similarities to HSV-1 gM protein and respective proteins of other herpesviruses of 37.5 % and 45.5 % to 31.8 % , respectively , was identified ."
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"id": "split_0_train_586_entity",
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"text": [
"gM"
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92,
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split_0_train_438 | split_0_train_438 | [
{
"id": "split_0_train_438_passage",
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"text": [
"A number of distinct transcriptional consensus sequences were found upstream of the first putative start codon of MDV2 UL10 protein ."
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{
"id": "split_0_train_587_entity",
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"UL10"
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119,
123
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split_0_train_439 | split_0_train_439 | [
{
"id": "split_0_train_439_passage",
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"text": [
"In transcriptional analysis , the gene was transcribed into an 1.5 kb RNA ."
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[
0,
75
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}
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split_0_train_440 | split_0_train_440 | [
{
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"The primary translation product comprises 424 amino acids with a predicted molecular weight of 46.9 kDa ."
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105
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split_0_train_441 | split_0_train_441 | [
{
"id": "split_0_train_441_passage",
"type": "progene_text",
"text": [
"The predicted MDV2 UL10 protein contains eight hydrophobic domains with sufficient length and hydrophobicity to span the lipid bilayer conserved in the genomes of all herpesviruses which have been sequenced so far ."
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"id": "split_0_train_588_entity",
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"UL10"
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19,
23
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split_0_train_442 | split_0_train_442 | [
{
"id": "split_0_train_442_passage",
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"text": [
"In the region located between the first and second hydrophobic domains , two potential N - linked glycosylation sites were presented ."
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0,
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] | [] | [] | [] | [] |
split_0_train_443 | split_0_train_443 | [
{
"id": "split_0_train_443_passage",
"type": "progene_text",
"text": [
"Interestingly , highly charged residues were abundantly possessed in the carboxy - terminal part of the MDV2 UL10 protein ."
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123
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{
"id": "split_0_train_589_entity",
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"UL10"
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109,
113
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}
] | [] | [] | [] |
split_0_train_444 | split_0_train_444 | [
{
"id": "split_0_train_444_passage",
"type": "progene_text",
"text": [
"By comparison of the amino acid sequence of the MDV2 UL10 gene with the homologues from other herpesviruses , the data might contribute for further evidence of the evolution of herpesviruses from a common progenitor and an ancient example of MDV2 belonging to the Alphaherpesvirinae subfamily ."
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{
"id": "split_0_train_590_entity",
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"text": [
"UL10"
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53,
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}
] | [] | [] | [] |
split_0_train_445 | split_0_train_445 | [
{
"id": "split_0_train_445_passage",
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"text": [
"In addition , the existence of corresponding genes in human , mammalian , and avian herpesvirus genomes , suggests indirectly an important role for gM in the natural life cycle of the virus ."
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[
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191
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{
"id": "split_0_train_591_entity",
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"text": [
"gM"
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[
148,
150
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split_0_train_446 | split_0_train_446 | [
{
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"text": [
"Escherichia coli mutants lacking all possible combinations of eight penicillin binding proteins : viability , characteristics , and implications for peptidoglycan synthesis ."
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174
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{
"id": "split_0_train_592_entity",
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68,
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split_0_train_447 | split_0_train_447 | [
{
"id": "split_0_train_447_passage",
"type": "progene_text",
"text": [
"The penicillin binding proteins ( PBPs ) synthesize and remodel peptidoglycan , the structural component of the bacterial cell wall ."
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"offsets": [
[
0,
133
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}
] | [
{
"id": "split_0_train_593_entity",
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4,
31
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{
"id": "split_0_train_594_entity",
"type": "progene_text",
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"PBPs"
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34,
38
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split_0_train_448 | split_0_train_448 | [
{
"id": "split_0_train_448_passage",
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"text": [
"Much is known about the biochemistry of these proteins , but little is known about their biological roles ."
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107
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] | [] | [] | [] | [] |
split_0_train_449 | split_0_train_449 | [
{
"id": "split_0_train_449_passage",
"type": "progene_text",
"text": [
"To better understand the contributions these proteins make to the physiology of Escherichia coli , we constructed 192 mutants from which eight PBP genes were deleted in every possible combination ."
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197
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{
"id": "split_0_train_595_entity",
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"PBP"
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143,
146
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split_0_train_450 | split_0_train_450 | [
{
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"text": [
"The genes encoding PBPs 1a , 1b , 4 , 5 , 6 , and 7 , AmpC , and AmpH were cloned , and from each gene an internal coding sequence was removed and replaced with a kanamycin resistance cassette flanked by two res sites from plasmid RP4 ."
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] | [
{
"id": "split_0_train_596_entity",
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"text": [
"PBPs 1a , 1b , 4 , 5 , 6 , and 7"
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19,
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{
"id": "split_0_train_597_entity",
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{
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"text": [
"AmpH"
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[
65,
69
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],
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}
] | [] | [] | [] |
split_0_train_451 | split_0_train_451 | [
{
"id": "split_0_train_451_passage",
"type": "progene_text",
"text": [
"Deletion of individual genes was accomplished by transferring each interrupted gene onto the chromosome of E. coli via lambda phage transduction and selecting for kanamycin - resistant recombinants ."
],
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[
0,
199
]
]
}
] | [] | [] | [] | [] |
split_0_train_452 | split_0_train_452 | [
{
"id": "split_0_train_452_passage",
"type": "progene_text",
"text": [
"Afterwards , the kanamycin resistance cassette was removed from each mutant strain by supplying ParA resolvase in trans , yielding a strain in which a long segment of the original PBP gene was deleted and replaced by an 8 - bp res site ."
],
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[
0,
237
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]
}
] | [
{
"id": "split_0_train_599_entity",
"type": "progene_text",
"text": [
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96,
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{
"id": "split_0_train_600_entity",
"type": "progene_text",
"text": [
"PBP"
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[
180,
183
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_453 | split_0_train_453 | [
{
"id": "split_0_train_453_passage",
"type": "progene_text",
"text": [
"These kanamycin - sensitive mutants were used as recipients in further rounds of replacement mutagenesis , resulting in a set of strains lacking from one to seven PBPs ."
],
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[
0,
169
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]
}
] | [
{
"id": "split_0_train_601_entity",
"type": "progene_text",
"text": [
"PBPs"
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163,
167
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],
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}
] | [] | [] | [] |
split_0_train_454 | split_0_train_454 | [
{
"id": "split_0_train_454_passage",
"type": "progene_text",
"text": [
"In addition , the dacD gene was deleted from two septuple mutants , creating strains lacking eight genes ."
],
"offsets": [
[
0,
106
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]
}
] | [
{
"id": "split_0_train_602_entity",
"type": "progene_text",
"text": [
"dacD"
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[
18,
22
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_455 | split_0_train_455 | [
{
"id": "split_0_train_455_passage",
"type": "progene_text",
"text": [
"The only deletion combinations not produced were those lacking both PBPs 1a and 1b because such a combination is lethal ."
],
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[
0,
121
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]
}
] | [
{
"id": "split_0_train_603_entity",
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"text": [
"PBPs 1a and 1b"
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"offsets": [
[
68,
82
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],
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}
] | [] | [] | [] |
split_0_train_456 | split_0_train_456 | [
{
"id": "split_0_train_456_passage",
"type": "progene_text",
"text": [
"Surprisingly , all other deletion mutants were viable even though , at the extreme , 8 of the 12 known PBPs had been eliminated ."
],
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[
0,
129
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]
}
] | [
{
"id": "split_0_train_604_entity",
"type": "progene_text",
"text": [
"PBPs"
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[
103,
107
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_457 | split_0_train_457 | [
{
"id": "split_0_train_457_passage",
"type": "progene_text",
"text": [
"Furthermore , when both PBPs 2 and 3 were inactivated by the beta-lactams mecillinam and aztreonam , respectively , several mutants did not lyse but continued to grow as enlarged spheres , so that one mutant synthesized osmotically resistant peptidoglycan when only 2 of 12 PBPs ( PBPs 1b and 1c ) remained active ."
],
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[
0,
315
]
]
}
] | [
{
"id": "split_0_train_605_entity",
"type": "progene_text",
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24,
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{
"id": "split_0_train_606_entity",
"type": "progene_text",
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{
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"type": "progene_text",
"text": [
"PBPs 1b and 1c"
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[
281,
295
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_458 | split_0_train_458 | [
{
"id": "split_0_train_458_passage",
"type": "progene_text",
"text": [
"These results have important implications for current models of peptidoglycan biosynthesis , for understanding the evolution of the bacterial sacculus , and for interpreting results derived by mutating unknown open reading frames in genome projects ."
],
"offsets": [
[
0,
250
]
]
}
] | [] | [] | [] | [] |
split_0_train_459 | split_0_train_459 | [
{
"id": "split_0_train_459_passage",
"type": "progene_text",
"text": [
"In addition , members of the set of PBP mutants will provide excellent starting points for answering fundamental questions about other aspects of cell wall metabolism ."
],
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[
0,
168
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]
}
] | [
{
"id": "split_0_train_608_entity",
"type": "progene_text",
"text": [
"PBP"
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"offsets": [
[
36,
39
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_460 | split_0_train_460 | [
{
"id": "split_0_train_460_passage",
"type": "progene_text",
"text": [
"A human Raf - responsive zinc - finger protein that binds to divergent sequences ."
],
"offsets": [
[
0,
82
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]
}
] | [
{
"id": "split_0_train_609_entity",
"type": "progene_text",
"text": [
"Raf - responsive zinc - finger protein"
],
"offsets": [
[
8,
46
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_461 | split_0_train_461 | [
{
"id": "split_0_train_461_passage",
"type": "progene_text",
"text": [
"LZ321 , a human liver cDNA , encodes a protein that bound to a Drosophila tramtrack binding site , GGTCCT ."
],
"offsets": [
[
0,
107
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]
}
] | [
{
"id": "split_0_train_610_entity",
"type": "progene_text",
"text": [
"LZ321"
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[
0,
5
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_462 | split_0_train_462 | [
{
"id": "split_0_train_462_passage",
"type": "progene_text",
"text": [
"The sequence of LZ321 matched that of RREB1 , a transcription factor that bound to a Ras responsive element ( RRE ) very different from the sequence with which we isolated LZ321 ."
],
"offsets": [
[
0,
179
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]
}
] | [
{
"id": "split_0_train_611_entity",
"type": "progene_text",
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16,
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{
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38,
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{
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"text": [
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48,
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{
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"type": "progene_text",
"text": [
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85,
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"type": "progene_text",
"text": [
"LZ321"
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172,
177
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_463 | split_0_train_463 | [
{
"id": "split_0_train_463_passage",
"type": "progene_text",
"text": [
"We therefore examined the binding of RREB1 / LZ321 to different ligands ."
],
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[
0,
73
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]
}
] | [
{
"id": "split_0_train_616_entity",
"type": "progene_text",
"text": [
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37,
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{
"id": "split_0_train_617_entity",
"type": "progene_text",
"text": [
"LZ321"
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"offsets": [
[
45,
50
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_464 | split_0_train_464 | [
{
"id": "split_0_train_464_passage",
"type": "progene_text",
"text": [
"It bound to the GGTCCT - containing ligand and to the RRE with similar affinities ( Kd50 - 60 nM ) , but did not bind to a consensus RREB1 binding site ."
],
"offsets": [
[
0,
153
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]
}
] | [
{
"id": "split_0_train_618_entity",
"type": "progene_text",
"text": [
"RREB1"
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"offsets": [
[
133,
138
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_465 | split_0_train_465 | [
{
"id": "split_0_train_465_passage",
"type": "progene_text",
"text": [
"The RREB1 / LZ321 protein contains four C2H2zinc - fingers , the C - terminal two of which retained specific DNA binding to both ligands ."
],
"offsets": [
[
0,
138
]
]
}
] | [
{
"id": "split_0_train_619_entity",
"type": "progene_text",
"text": [
"RREB1"
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4,
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},
{
"id": "split_0_train_620_entity",
"type": "progene_text",
"text": [
"LZ321"
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"offsets": [
[
12,
17
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_466 | split_0_train_466 | [
{
"id": "split_0_train_466_passage",
"type": "progene_text",
"text": [
"A trimer of the GGTCCT site functioned as an enhancer in both CV-1 and H4IIE-C3 cells ."
],
"offsets": [
[
0,
87
]
]
}
] | [] | [] | [] | [] |
split_0_train_467 | split_0_train_467 | [
{
"id": "split_0_train_467_passage",
"type": "progene_text",
"text": [
"Thus RREB1 / LZ321 could function as a downstream activator in the Ras - Raf signaling pathway through different cis - acting elements ."
],
"offsets": [
[
0,
136
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]
}
] | [
{
"id": "split_0_train_621_entity",
"type": "progene_text",
"text": [
"RREB1"
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5,
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{
"id": "split_0_train_622_entity",
"type": "progene_text",
"text": [
"LZ321"
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13,
18
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{
"id": "split_0_train_623_entity",
"type": "progene_text",
"text": [
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67,
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},
{
"id": "split_0_train_624_entity",
"type": "progene_text",
"text": [
"Raf"
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"offsets": [
[
73,
76
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_468 | split_0_train_468 | [
{
"id": "split_0_train_468_passage",
"type": "progene_text",
"text": [
"A longer human protein , Finb , contains RREB1 / LZ321 , and there are close homologs in both chicken and Drosophila , arguing that it plays important roles ."
],
"offsets": [
[
0,
158
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]
}
] | [
{
"id": "split_0_train_625_entity",
"type": "progene_text",
"text": [
"Finb"
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25,
29
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{
"id": "split_0_train_626_entity",
"type": "progene_text",
"text": [
"RREB1"
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41,
46
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{
"id": "split_0_train_627_entity",
"type": "progene_text",
"text": [
"LZ321"
],
"offsets": [
[
49,
54
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_469 | split_0_train_469 | [
{
"id": "split_0_train_469_passage",
"type": "progene_text",
"text": [
"The ability of transcription factors such as RREB1 / LZ321 to bind diverse sequences gives them the potential to regulate previously unsuspected genes ."
],
"offsets": [
[
0,
152
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]
}
] | [
{
"id": "split_0_train_628_entity",
"type": "progene_text",
"text": [
"transcription factors"
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15,
36
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},
{
"id": "split_0_train_629_entity",
"type": "progene_text",
"text": [
"RREB1"
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45,
50
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{
"id": "split_0_train_630_entity",
"type": "progene_text",
"text": [
"LZ321"
],
"offsets": [
[
53,
58
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_470 | split_0_train_470 | [
{
"id": "split_0_train_470_passage",
"type": "progene_text",
"text": [
"Bovine papillomavirus E2 protein activates a complex growth - inhibitory program in p53 - negative HT-3 cervical carcinoma cells that includes repression of cyclin A and cdc25A phosphatase genes and accumulation of hypophosphorylated retinoblastoma protein ."
],
"offsets": [
[
0,
258
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]
}
] | [
{
"id": "split_0_train_631_entity",
"type": "progene_text",
"text": [
"E2 protein"
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22,
32
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],
"normalized": []
},
{
"id": "split_0_train_632_entity",
"type": "progene_text",
"text": [
"p53"
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[
84,
87
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],
"normalized": []
},
{
"id": "split_0_train_633_entity",
"type": "progene_text",
"text": [
"cyclin A"
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[
157,
165
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],
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},
{
"id": "split_0_train_634_entity",
"type": "progene_text",
"text": [
"cdc25A phosphatase"
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170,
188
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},
{
"id": "split_0_train_635_entity",
"type": "progene_text",
"text": [
"retinoblastoma protein"
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"offsets": [
[
234,
256
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],
"normalized": []
}
] | [] | [] | [] |
split_0_train_471 | split_0_train_471 | [
{
"id": "split_0_train_471_passage",
"type": "progene_text",
"text": [
"The bovine papillomavirus E2 protein can inhibit the proliferation of HT-3 cells , a p53 - negative cervical carcinoma cell line containing integrated human papillomavirus type 30 DNA ."
],
"offsets": [
[
0,
185
]
]
}
] | [
{
"id": "split_0_train_636_entity",
"type": "progene_text",
"text": [
"E2 protein"
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[
26,
36
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],
"normalized": []
},
{
"id": "split_0_train_637_entity",
"type": "progene_text",
"text": [
"p53"
],
"offsets": [
[
85,
88
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_472 | split_0_train_472 | [
{
"id": "split_0_train_472_passage",
"type": "progene_text",
"text": [
"Here , we analyzed HT-3 cells to explore the mechanism of p53 - independent E2 - mediated growth inhibition ."
],
"offsets": [
[
0,
109
]
]
}
] | [
{
"id": "split_0_train_638_entity",
"type": "progene_text",
"text": [
"p53"
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58,
61
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},
{
"id": "split_0_train_639_entity",
"type": "progene_text",
"text": [
"E2"
],
"offsets": [
[
76,
78
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_473 | split_0_train_473 | [
{
"id": "split_0_train_473_passage",
"type": "progene_text",
"text": [
"Expression of the E2 protein repressed expression of the endogenous human papillomavirus type 30 E6 / E7 genes ."
],
"offsets": [
[
0,
112
]
]
}
] | [
{
"id": "split_0_train_640_entity",
"type": "progene_text",
"text": [
"E2 protein"
],
"offsets": [
[
18,
28
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],
"normalized": []
},
{
"id": "split_0_train_641_entity",
"type": "progene_text",
"text": [
"E6"
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"offsets": [
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97,
99
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],
"normalized": []
},
{
"id": "split_0_train_642_entity",
"type": "progene_text",
"text": [
"E7"
],
"offsets": [
[
102,
104
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_474 | split_0_train_474 | [
{
"id": "split_0_train_474_passage",
"type": "progene_text",
"text": [
"This was accompanied by hypophosphorylation and increased accumulation of p105Rb and repression of E2F1 expression ."
],
"offsets": [
[
0,
116
]
]
}
] | [
{
"id": "split_0_train_643_entity",
"type": "progene_text",
"text": [
"p105Rb"
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74,
80
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"normalized": []
},
{
"id": "split_0_train_644_entity",
"type": "progene_text",
"text": [
"E2F1"
],
"offsets": [
[
99,
103
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_475 | split_0_train_475 | [
{
"id": "split_0_train_475_passage",
"type": "progene_text",
"text": [
"The E2 protein also caused reduced cyclin - dependent kinase ( cdk ) 2 activity , but this did not appear to be due to increased expression of cdk inhibitors ."
],
"offsets": [
[
0,
159
]
]
}
] | [
{
"id": "split_0_train_645_entity",
"type": "progene_text",
"text": [
"E2 protein"
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[
4,
14
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],
"normalized": []
},
{
"id": "split_0_train_646_entity",
"type": "progene_text",
"text": [
"cyclin - dependent kinase ( cdk ) 2"
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[
35,
70
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],
"normalized": []
},
{
"id": "split_0_train_647_entity",
"type": "progene_text",
"text": [
"cdk inhibitors"
],
"offsets": [
[
143,
157
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_476 | split_0_train_476 | [
{
"id": "split_0_train_476_passage",
"type": "progene_text",
"text": [
"Rather , expression of cyclin A , which regulates cdk2 activity , and the cdc25A and cdc25B phosphatases , which are thought to activate cdk2 , was significantly reduced at both the RNA and protein levels in response to E2 expression ."
],
"offsets": [
[
0,
235
]
]
}
] | [
{
"id": "split_0_train_648_entity",
"type": "progene_text",
"text": [
"cyclin A"
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[
23,
31
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},
{
"id": "split_0_train_649_entity",
"type": "progene_text",
"text": [
"cdk2"
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50,
54
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],
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},
{
"id": "split_0_train_650_entity",
"type": "progene_text",
"text": [
"cdc25A"
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[
74,
80
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],
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},
{
"id": "split_0_train_651_entity",
"type": "progene_text",
"text": [
"cdc25B phosphatases"
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85,
104
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{
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137,
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{
"id": "split_0_train_653_entity",
"type": "progene_text",
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"E2"
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220,
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"normalized": []
}
] | [] | [] | [] |
split_0_train_477 | split_0_train_477 | [
{
"id": "split_0_train_477_passage",
"type": "progene_text",
"text": [
"The E2 protein reduced expression of cdc25A and cdc25B in both HT-3 and HeLa cells , but not in cells that were not growth - inhibited by the E2 protein ."
],
"offsets": [
[
0,
154
]
]
}
] | [
{
"id": "split_0_train_654_entity",
"type": "progene_text",
"text": [
"E2 protein"
],
"offsets": [
[
4,
14
]
],
"normalized": []
},
{
"id": "split_0_train_655_entity",
"type": "progene_text",
"text": [
"cdc25A"
],
"offsets": [
[
37,
43
]
],
"normalized": []
},
{
"id": "split_0_train_656_entity",
"type": "progene_text",
"text": [
"cdc25B"
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"offsets": [
[
48,
54
]
],
"normalized": []
},
{
"id": "split_0_train_657_entity",
"type": "progene_text",
"text": [
"E2 protein"
],
"offsets": [
[
142,
152
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_478 | split_0_train_478 | [
{
"id": "split_0_train_478_passage",
"type": "progene_text",
"text": [
"E2 point mutants unable to inhibit cell growth did not repress cdc25A and cdc25B expression , nor did the cell cycle inhibitors hydroxyurea and mimosine ."
],
"offsets": [
[
0,
154
]
]
}
] | [
{
"id": "split_0_train_658_entity",
"type": "progene_text",
"text": [
"E2"
],
"offsets": [
[
0,
2
]
],
"normalized": []
},
{
"id": "split_0_train_659_entity",
"type": "progene_text",
"text": [
"cdc25A"
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[
63,
69
]
],
"normalized": []
},
{
"id": "split_0_train_660_entity",
"type": "progene_text",
"text": [
"cdc25B"
],
"offsets": [
[
74,
80
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_479 | split_0_train_479 | [
{
"id": "split_0_train_479_passage",
"type": "progene_text",
"text": [
"Based on these results and the known properties of cell cycle components , we propose a model to account for E2 - induced growth inhibition of cervical carcinoma cell lines ."
],
"offsets": [
[
0,
174
]
]
}
] | [
{
"id": "split_0_train_661_entity",
"type": "progene_text",
"text": [
"E2"
],
"offsets": [
[
109,
111
]
],
"normalized": []
}
] | [] | [] | [] |
split_0_train_480 | split_0_train_480 | [
{
"id": "split_0_train_480_passage",
"type": "progene_text",
"text": [
"Wrist measurement of blood pressure : some critical remarks to oscillometry ."
],
"offsets": [
[
0,
77
]
]
}
] | [] | [] | [] | [] |
split_0_train_481 | split_0_train_481 | [
{
"id": "split_0_train_481_passage",
"type": "progene_text",
"text": [
"Oscillometric blood pressure measuring devices worn at the wrist are preferred by a growing part of hypertensive patients for self - measurement because of their compactness and ease of use ."
],
"offsets": [
[
0,
191
]
]
}
] | [] | [] | [] | [] |
split_0_train_482 | split_0_train_482 | [
{
"id": "split_0_train_482_passage",
"type": "progene_text",
"text": [
"However , little is known about the accuracy of such instruments ."
],
"offsets": [
[
0,
66
]
]
}
] | [] | [] | [] | [] |
split_0_train_483 | split_0_train_483 | [
{
"id": "split_0_train_483_passage",
"type": "progene_text",
"text": [
"The accuracy of such devices was evaluated by measuring the blood pressure at the end of a coronary angiography procedure in 27 subjects nearly simultaneously in the aortic arch , using a Statham P23 transducer , and at the wrist , using the blood pressure watch ( BPW ) by NAIS-Matsushita ."
],
"offsets": [
[
0,
291
]
]
}
] | [] | [] | [] | [] |
split_0_train_484 | split_0_train_484 | [
{
"id": "split_0_train_484_passage",
"type": "progene_text",
"text": [
"Four replicate comparative measurements were performed in each subject ."
],
"offsets": [
[
0,
72
]
]
}
] | [] | [] | [] | [] |
split_0_train_485 | split_0_train_485 | [
{
"id": "split_0_train_485_passage",
"type": "progene_text",
"text": [
"On average , the blood pressure measured by the BPW was found to be higher : systolic + 1.2 +/- ( SD ) 10.2 mm Hg , diastolic + 4.1 +/- 7.2 mm Hg ."
],
"offsets": [
[
0,
147
]
]
}
] | [] | [] | [] | [] |
split_0_train_486 | split_0_train_486 | [
{
"id": "split_0_train_486_passage",
"type": "progene_text",
"text": [
"The correlation coefficient between the two methods was 0.85 for the systolic and 0.84 for the diastolic pressure , but 39 % of the systolic and 22 % of the diastolic differences were outside the range of +/-1 SD ."
],
"offsets": [
[
0,
214
]
]
}
] | [] | [] | [] | [] |
split_0_train_487 | split_0_train_487 | [
{
"id": "split_0_train_487_passage",
"type": "progene_text",
"text": [
"There was no correlation between systolic differences and blood pressure or patients ' variables , but multiple regression analysis revealed that the diastolic blood pressure differences were negatively correlated with the aortic diastolic pressure ( r = 0.89 , p < 0.001 ) , indicating that the BPW is less accurate to detect lower values ."
],
"offsets": [
[
0,
341
]
]
}
] | [] | [] | [] | [] |
split_0_train_488 | split_0_train_488 | [
{
"id": "split_0_train_488_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
] | [] | [] | [] | [] |
split_0_train_489 | split_0_train_489 | [
{
"id": "split_0_train_489_passage",
"type": "progene_text",
"text": [
"(1 )"
],
"offsets": [
[
0,
4
]
]
}
] | [] | [] | [] | [] |
split_0_train_490 | split_0_train_490 | [
{
"id": "split_0_train_490_passage",
"type": "progene_text",
"text": [
"Though the average systolic and diastolic deviations between both methods and the relative correlation coefficients suggest that the BPW is to be used carefully for monitoring blood pressure , the great variability of differences and the inability of the BPW to detect lower diastolic blood pressure calls for a mandatory validation test by an approved protocol before this new device can be recommended for general use ."
],
"offsets": [
[
0,
421
]
]
}
] | [] | [] | [] | [] |
split_0_train_491 | split_0_train_491 | [
{
"id": "split_0_train_491_passage",
"type": "progene_text",
"text": [
"(2 )"
],
"offsets": [
[
0,
4
]
]
}
] | [] | [] | [] | [] |
split_0_train_492 | split_0_train_492 | [
{
"id": "split_0_train_492_passage",
"type": "progene_text",
"text": [
"On the basis of our results for wrist oscillometry with the BPW and data reported in the literature for upper - arm oscillometric devices , we recommend to use oscillometric devices only when they were validated properly ."
],
"offsets": [
[
0,
222
]
]
}
] | [] | [] | [] | [] |
split_0_train_493 | split_0_train_493 | [
{
"id": "split_0_train_493_passage",
"type": "progene_text",
"text": [
"In particular , the oscillometric measurement should be employed with caution for epidemiological studies or for investigation of population groups ( e.g. , children or pregnant women ) that are expected to display lower diastolic pressures ."
],
"offsets": [
[
0,
242
]
]
}
] | [] | [] | [] | [] |
split_0_train_494 | split_0_train_494 | [
{
"id": "split_0_train_494_passage",
"type": "progene_text",
"text": [
"A multi - centre evaluation of the card indirect agglutination test for trypanosomiasis ( TrypTect CIATT ) ."
],
"offsets": [
[
0,
108
]
]
}
] | [] | [] | [] | [] |
split_0_train_495 | split_0_train_495 | [
{
"id": "split_0_train_495_passage",
"type": "progene_text",
"text": [
"A version of the card indirect agglutination test for trypanosomiasis , the TrypTect CIATT , was evaluated for the diagnosis of Trypanosoma brucei gambiense and T. b. rhodesiense sleeping sickness ."
],
"offsets": [
[
0,
198
]
]
}
] | [] | [] | [] | [] |
split_0_train_496 | split_0_train_496 | [
{
"id": "split_0_train_496_passage",
"type": "progene_text",
"text": [
"The results of this antigen - detection test indicated high relative sensitivity ( 99.3 % ) and specificity ( 99.4 % ) , and also much higher prevalences of infection in the general population of endemic foci ( 27.9 % for T. b. gambiense and 21.8 % for T. b. rhodesiense ) than detected by parasitological diagnosis ( 1.6 % and 1.1 % , respectively ) ."
],
"offsets": [
[
0,
352
]
]
}
] | [] | [] | [] | [] |
split_0_train_497 | split_0_train_497 | [
{
"id": "split_0_train_497_passage",
"type": "progene_text",
"text": [
"TrypTect CIATT detected ( and could therefore be used for the diagnosis of ) non - patent infections ."
],
"offsets": [
[
0,
102
]
]
}
] | [] | [] | [] | [] |
split_0_train_498 | split_0_train_498 | [
{
"id": "split_0_train_498_passage",
"type": "progene_text",
"text": [
"Among the suspected cases ( i.e. those initially found to be parasite - negative but to be antigen - positive ) , trypanosomes were detected in 29 ( 4.2 % ) of those checked at a 3 - month follow - up , and 17 more such suspects when they were followed up at 6 - 18 months ."
],
"offsets": [
[
0,
274
]
]
}
] | [] | [] | [] | [] |
split_0_train_499 | split_0_train_499 | [
{
"id": "split_0_train_499_passage",
"type": "progene_text",
"text": [
"Moreover , a high proportion of blood samples from a random sample of the rest of the suspects tested positive for trypanosome - specific DNA by PCR ( 79.9 % for T. b. gambiense and 13.9 % for T. b. rhodesiense ) ."
],
"offsets": [
[
0,
214
]
]
}
] | [] | [] | [] | [] |