hcaoaf/MoleculeQA · Datasets at Hugging Face

text stringlengths 3 799
Option A: It inhibits the accumulation of the pro-inflammatory iNOS protein.
Option B: It exhibits the action of concentrating its anti-inflammatory action at the site of application due to being a privalate salt.
Option C: It has cardiac stimulant action without evoking vasoconstriction or tachycardia.
Option D: It has vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions.
" A
5280497 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCCCC[C@@H](/C=C/[C@@H]1[C@H]([C@@H]2C[C@@H](O2)O1)C/C=C\\CCCC(=O)O)O
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It stimulates activation of new platelets and increases platelet aggregation.
Option B: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter.
Option C: It mediates smooth muscle relaxation and bronchodilation.
Option D: It mediates a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis.
" A
10743861 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCCCC(C)/C=C/C(=O)NC1=C[C@@]([C@H]2[C@@H](C1=O)O2)(/C=C/C=C/C=C/C(=O)NC3=C(CCC3=O)O)O
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It acts as an anti-inflammatory agent and antibiotic.
Option B: It is an anti-arrhythmia drug and a sodium channel blocker.
Option C: It is a calcium-channel blocker and vasodilator.
Option D: It acts as an L-type calcium channel blocker.
" A
53355241 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@@H]1[C@H](C(=O)O[C@H]1[C@H]([C@@H](C)[C@H]2CC[C@@H]3[C@@]2(CC[C@H]4[C@H]3CCC5=CC(=O)C=C[C@]45C)COC(=O)C)O)C
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It exhibits the action of concentrating its anti-inflammatory action at the site of application due to being a privalate salt.
Option B: It has vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions.
Option C: It has cardiac stimulant action without evoking vasoconstriction or tachycardia.
Option D: It inhibits the accumulation of the pro-inflammatory iNOS protein.
" D
10219 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC[C@H]1CN2CCC3=CC(=C(C=C3[C@@H]2C[C@@H]1C[C@@H]4C5=CC(=C(C=C5CCN4)OC)OC)OC)OC
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It inhibits SARS-CoV2, Zika and Ebola virus replication and displays antimalarial, antineoplastic and antiamoebic properties.
Option B: It is an inhibitor of SARS coronavirus main proteinase and inhibits SARS-CoV-2 replication in cell culture.
Option C: It prevents the interaction of HIV-1 gp120 and chemokine receptor 5 (CCR5) necessary for CCR5-tropic HIV-1 to enter cells.
Option D: It inhibits the increase in promoter activity observed following overexpression of PKCdelta, constitutively active Ras, or MEKK1.
" A
3385 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=C(C(=O)NC(=O)N1)F
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It inhibits acetylcholinesterase.
Option B: It acts by inhibition of cholinesterase activity.
Option C: It inhibits cholinesterase enzyme.
Option D: It inhibits DNA synthesis by blocking the conversion of deoxyuridylic acid to thymidylic acid.
" D
135411330 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C2C(=C1)C=CC(=N2)/C=C/C3=CC=CC=C3O
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter.
Option B: It exerts a dose-dependent antagonism of the cysteinyl leukotriene pathway, preferentially antagonizing cysteinyl leukotriene receptor 1.
Option C: It is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity.
Option D: It exerts a dose-dependent antagonism of the cysteinyl leukotriene pathway and preferentially antagonizes cysteinyl leukotriene receptor 1.
" D
11363812 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C[C@]12CCC3=C([C@@]1(CC[C@@H]2[C@@H](CC[C@@H](C(C)(C)O)O)C(=O)O)C)CC[C@@H]4[C@@]3(CCC(=O)C4(C)C)C
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It exhibits antiinflammatory activity against cylooxygenase-1 (COX-1) and cylooxygenase-2 (COX-2).
Option B: It exhibits the action of mediating at least some of its immunomodulatory actions via inhibition of cyclic adenosine monophosphate (cAMP)-phosphodiesterase (PDE), and consequential increase in intracellular cAMP concentrations.
Option C: It has multiple actions, including activating GABA(B) receptors, enhancing NMDA current, blocking AMPA-receptor-mediated transmission, binding to the L-alpha-amino acid transporter, activating ATP-sensitive K(+) channels, activating hyperpolarization-activated cation channels, and modulating Ca(2+) current.
Option D: It is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity.
" A
10796739 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CN=CC(=C1N)CO
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It competes with serotonin at receptor sites in smooth muscle.
Option B: It causes relaxation of smooth muscle in blood vessels and the prostate.
Option C: It has direct actions on blood vessels and increases cardiac output.
Option D: It restores axonal conduction after spinal cord injury.
" D
439530 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN(C)C1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)NC(=O)[C@H](CC4=CC=C(C=C4)OC)N)O
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It interacts with 14-α demethylase.
Option B: It causes premature chain termination during translation taking place in the ribosome.
Option C: It interacts with 14-alpha demethylase.
Option D: It inhibits DNA synthesis and interacts with SH groups.
" B
2856102 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCOC(=O)C1=C(NC(=C(C1C2=C(C(=C(C(=C2F)F)F)F)F)C(=O)OCC)C)C
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It is commonly associated with serum enzyme elevations during therapy and to rare instances of clinically apparent acute liver injury.
Option B: It exhibits the action of acting as an inhibitor of cholinesterase and being highly toxic by all routes of exposure.
Option C: It induces a variety of defects including those affecting morphology and egg laying.
Option D: It provides a totally novel mode of action with potential importance for diseases associated with ageing of the brain.
" C
1884 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC2=C(C=C1Cl)NC(=CC2=O)C(=O)O
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter.
Option B: It is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity.
Option C: It has multiple actions, including activating GABA(B) receptors, enhancing NMDA current, blocking AMPA-receptor-mediated transmission, binding to the L-alpha-amino acid transporter, activating ATP-sensitive K(+) channels, activating hyperpolarization-activated cation channels, and modulating Ca(2+) current.
Option D: It antagonizes the strychnine-insensitive glycine site of the NMDA receptor and prevents neurodegeneration produced by quinolinic acid.
" D
6082 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C(C1=C(C=CC(=C1)OC)OC)O)N
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter.
Option B: It acts directly at alpha-adrenoceptors with selectivity for the alpha-1 adrenoceptor subtype similar to phenylephrine.
Option C: It antagonizes the strychnine-insensitive glycine site of the NMDA receptor and prevents neurodegeneration produced by quinolinic acid.
Option D: It is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity.

Option A: It inhibits the accumulation of the pro-inflammatory iNOS protein.

Option B: It exhibits the action of concentrating its anti-inflammatory action at the site of application due to being a privalate salt.

Option C: It has cardiac stimulant action without evoking vasoconstriction or tachycardia.

Option D: It has vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions.

" A

5280497 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CCCCC[C@@H](/C=C/[C@@H]1[C@H]([C@@H]2C[C@@H](O2)O1)C/C=C\\CCCC(=O)O)O

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: It stimulates activation of new platelets and increases platelet aggregation.

Option B: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter.

Option C: It mediates smooth muscle relaxation and bronchodilation.

Option D: It mediates a cytotoxic action on colorectal cancer cells by inducing cell arrest and apoptosis.

" A

10743861 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CCCCC(C)/C=C/C(=O)NC1=C[C@@]([C@H]2[C@@H](C1=O)O2)(/C=C/C=C/C=C/C(=O)NC3=C(CCC3=O)O)O

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: It acts as an anti-inflammatory agent and antibiotic.

Option B: It is an anti-arrhythmia drug and a sodium channel blocker.

Option C: It is a calcium-channel blocker and vasodilator.

Option D: It acts as an L-type calcium channel blocker.

" A

53355241 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: C[C@@H]1[C@H](C(=O)O[C@H]1[C@H]([C@@H](C)[C@H]2CC[C@@H]3[C@@]2(CC[C@H]4[C@H]3CCC5=CC(=O)C=C[C@]45C)COC(=O)C)O)C

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: It exhibits the action of concentrating its anti-inflammatory action at the site of application due to being a privalate salt.

Option B: It has vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions.

Option C: It has cardiac stimulant action without evoking vasoconstriction or tachycardia.

Option D: It inhibits the accumulation of the pro-inflammatory iNOS protein.

" D

10219 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CC[C@H]1CN2CCC3=CC(=C(C=C3[C@@H]2C[C@@H]1C[C@@H]4C5=CC(=C(C=C5CCN4)OC)OC)OC)OC

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: It inhibits SARS-CoV2, Zika and Ebola virus replication and displays antimalarial, antineoplastic and antiamoebic properties.

Option B: It is an inhibitor of SARS coronavirus main proteinase and inhibits SARS-CoV-2 replication in cell culture.

Option C: It prevents the interaction of HIV-1 gp120 and chemokine receptor 5 (CCR5) necessary for CCR5-tropic HIV-1 to enter cells.

Option D: It inhibits the increase in promoter activity observed following overexpression of PKCdelta, constitutively active Ras, or MEKK1.

" A

3385 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: C1=C(C(=O)NC(=O)N1)F

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: It inhibits acetylcholinesterase.

Option B: It acts by inhibition of cholinesterase activity.

Option C: It inhibits cholinesterase enzyme.

Option D: It inhibits DNA synthesis by blocking the conversion of deoxyuridylic acid to thymidylic acid.

" D

135411330 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: C1=CC=C2C(=C1)C=CC(=N2)/C=C/C3=CC=CC=C3O

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter.

Option B: It exerts a dose-dependent antagonism of the cysteinyl leukotriene pathway, preferentially antagonizing cysteinyl leukotriene receptor 1.

Option C: It is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity.

Option D: It exerts a dose-dependent antagonism of the cysteinyl leukotriene pathway and preferentially antagonizes cysteinyl leukotriene receptor 1.

" D

11363812 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: C[C@]12CCC3=C([C@@]1(CC[C@@H]2[C@@H](CC[C@@H](C(C)(C)O)O)C(=O)O)C)CC[C@@H]4[C@@]3(CCC(=O)C4(C)C)C

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: It exhibits antiinflammatory activity against cylooxygenase-1 (COX-1) and cylooxygenase-2 (COX-2).

Option B: It exhibits the action of mediating at least some of its immunomodulatory actions via inhibition of cyclic adenosine monophosphate (cAMP)-phosphodiesterase (PDE), and consequential increase in intracellular cAMP concentrations.

Option C: It has multiple actions, including activating GABA(B) receptors, enhancing NMDA current, blocking AMPA-receptor-mediated transmission, binding to the L-alpha-amino acid transporter, activating ATP-sensitive K(+) channels, activating hyperpolarization-activated cation channels, and modulating Ca(2+) current.

Option D: It is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity.

" A

10796739 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: C1=CN=CC(=C1N)CO

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: It competes with serotonin at receptor sites in smooth muscle.

Option B: It causes relaxation of smooth muscle in blood vessels and the prostate.

Option C: It has direct actions on blood vessels and increases cardiac output.

Option D: It restores axonal conduction after spinal cord injury.

" D

439530 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CN(C)C1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)NC(=O)[C@H](CC4=CC=C(C=C4)OC)N)O

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: It interacts with 14-α demethylase.

Option B: It causes premature chain termination during translation taking place in the ribosome.

Option C: It interacts with 14-alpha demethylase.

Option D: It inhibits DNA synthesis and interacts with SH groups.

" B

2856102 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CCOC(=O)C1=C(NC(=C(C1C2=C(C(=C(C(=C2F)F)F)F)F)C(=O)OCC)C)C

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: It is commonly associated with serum enzyme elevations during therapy and to rare instances of clinically apparent acute liver injury.

Option B: It exhibits the action of acting as an inhibitor of cholinesterase and being highly toxic by all routes of exposure.

Option C: It induces a variety of defects including those affecting morphology and egg laying.

Option D: It provides a totally novel mode of action with potential importance for diseases associated with ageing of the brain.

" C

1884 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: C1=CC2=C(C=C1Cl)NC(=CC2=O)C(=O)O

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter.

Option B: It is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity.

Option C: It has multiple actions, including activating GABA(B) receptors, enhancing NMDA current, blocking AMPA-receptor-mediated transmission, binding to the L-alpha-amino acid transporter, activating ATP-sensitive K(+) channels, activating hyperpolarization-activated cation channels, and modulating Ca(2+) current.

Option D: It antagonizes the strychnine-insensitive glycine site of the NMDA receptor and prevents neurodegeneration produced by quinolinic acid.

" D

6082 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CC(C(C1=C(C=CC(=C1)OC)OC)O)N

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: It exhibits the actions of being a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter.

Option B: It acts directly at alpha-adrenoceptors with selectivity for the alpha-1 adrenoceptor subtype similar to phenylephrine.

Option C: It antagonizes the strychnine-insensitive glycine site of the NMDA receptor and prevents neurodegeneration produced by quinolinic acid.

Option D: It is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity.