hcaoaf/MoleculeQA · Datasets at Hugging Face

text stringlengths 3 799
Option A: It has systemic protective and curative action.
Option B: It has curative, protective, and eradicant action.
Option C: It has systemic protective, curative, and eradicant action.
Option D: It works systemically and on contact as an organophosphorus insecticide and acaricide.
" D
10680 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C(C=C1)C2=CC(=O)C3=CC=CC=C3O2
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It inhibits both the manufacture and release of histamine and other allergic/inflammatory mediators.
Option B: It interacts with various anti-anginal or anti-hypertensive agents to develop potentially rapid, excessive, and/or fatal hypotensive crises.
Option C: It exhibits the action of having a delayed onset, narrow therapeutic window, need for regular monitoring and INR testing, and numerous drug-drug and drug-food interactions, which limits its effective use for stroke prevention.
Option D: It is used for the prevention and management of angina pectoris caused by coronary artery disease, but its onset of action is not rapid enough to offset an acute anginal episode.
" A
4055 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC(=O)C2=CC=CC=C2C1=O
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: Its supplements have been banned by the FDA because of their high toxicity.
Option B: It has direct actions on blood vessels and increases cardiac output.
Option C: It is commonly associated with serum enzyme elevations during therapy and to rare instances of clinically apparent acute liver injury.
Option D: It provides a totally novel mode of action with potential importance for diseases associated with ageing of the brain.
" A
151166 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC(=C(C=C1)NC2=C(C=CC=C2Cl)F)CC(=O)O
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It has direct actions on blood vessels and increases cardiac output.
Option B: It may cause liver failure.
Option C: It provides a totally novel mode of action with potential importance for diseases associated with ageing of the brain.
Option D: It causes relaxation of smooth muscle in blood vessels and the prostate.
" B
2733526 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC/C(=C(\\C1=CC=CC=C1)/C2=CC=C(C=C2)OCCN(C)C)/C3=CC=CC=C3
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity.
Option B: It has multiple actions, including activating GABA(B) receptors, enhancing NMDA current, blocking AMPA-receptor-mediated transmission, binding to the L-alpha-amino acid transporter, activating ATP-sensitive K(+) channels, activating hyperpolarization-activated cation channels, and modulating Ca(2+) current.
Option C: It exhibits the action of mediating at least some of its immunomodulatory actions via inhibition of cyclic adenosine monophosphate (cAMP)-phosphodiesterase (PDE), and consequential increase in intracellular cAMP concentrations.
Option D: It interacts with other coactivators or corepressors in the tissue and binds with different estrogen receptors, ER-alpha or ER-beta.
" D
25154714 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)[C@@H](C(=O)N1CCC[C@H]1C2=NC=C(N2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C(N5)[C@@H]6CCCN6C(=O)[C@H](C(C)C)NC(=O)OC)NC(=O)OC
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme.
Option B: It prevents RNA replication and virion assembly via binding to NS5A, a nonstructural phosphoprotein encoded by HCV.
Option C: It has systemic protective, curative, and eradicant action.
Option D: It has cardiac stimulant action without evoking vasoconstriction or tachycardia.
" B
2266 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C(CCCC(=O)O)CCCC(=O)O
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It inhibits microbial cellular protein synthesis.
Option B: It inhibits DNA synthesis.
Option C: It interferes with bacterial protein synthesis.
Option D: It inhibits bacterial protein synthesis.
" A
24934 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: [O-][Se](=O)[O-].[Na+].[Na+]
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It provides a totally novel mode of action with potential importance for diseases associated with ageing of the brain.
Option B: It is very irritating to skin and mucous membranes and has keratolytic actions.
Option C: It cancels out the green color imparted by iron impurities.
Option D: It undergoes biotransformation to form the active moiety for antifungal actions.
" C
2833 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It causes premature chain termination during translation taking place in the ribosome.
Option B: It interacts with 14-alpha demethylase.
Option C: It may be at least partially involved in a certain action.
Option D: It inhibits DNA synthesis and interacts with SH groups.
" C
34328 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1CN(CCC1(C2=CC=CC=C2)C(=O)O)CCC(C#N)(C3=CC=CC=C3)C4=CC=CC=C4
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It first acts on the mu-opioid receptors.
Option B: It activates opioid receptors in the intestine.
Option C: It selectively inhibits mitosis and cell division.
Option D: It interacts predominantly with the opioid mu-receptors.
" B
5281081 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCN(CC)C(=O)/C(=C/C1=CC(=C(C(=C1)O)O)[N+](=O)[O-])/C#N
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It has direct actions on blood vessels and increases cardiac output.
Option B: It can inhibit phosphodiesterases and may have direct actions on calcium channels.
Option C: It can act on both N-type and L-type calcium channels.
Option D: It can increase and sustain plasma levodopa concentrations.
" D
446157 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)C1=NC(=NC(=C1/C=C/[C@H](C[C@H](CC(=O)O)O)O)C2=CC=C(C=C2)F)N(C)S(=O)(=O)C
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It has less risk of drug-drug interactions compared to certain other drugs.
Option B: It has reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug interactions.
Option C: It exhibits the action of having a delayed onset, narrow therapeutic window, need for regular monitoring and INR testing, and numerous drug-drug and drug-food interactions, which limits its effective use for stroke prevention.
Option D: It exhibits the action of having a reduced propensity for involvement in drug-drug interactions owing to its primarily reductive metabolism.
" A
5610 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC(=CC=C1CCN)O
Question about this molecule: Which kind of action does this molecule have/exhibit?
Option A: It has cardiac stimulant action without evoking vasoconstriction or tachycardia.
Option B: It exhibits the actions of being an extremely potent uncoupler of oxidative phosphorylation in mitochondria and having high reactivity with thiols.
Option C: It can cause hypertensive crisis when ingested with tyramine-rich diet.
Option D: It is used for the prevention and management of angina pectoris caused by coronary artery disease, but its onset of action is not rapid enough to offset an acute anginal episode.

Option A: It has systemic protective and curative action.

Option B: It has curative, protective, and eradicant action.

Option C: It has systemic protective, curative, and eradicant action.

Option D: It works systemically and on contact as an organophosphorus insecticide and acaricide.

" D

10680 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: C1=CC=C(C=C1)C2=CC(=O)C3=CC=CC=C3O2

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: It inhibits both the manufacture and release of histamine and other allergic/inflammatory mediators.

Option B: It interacts with various anti-anginal or anti-hypertensive agents to develop potentially rapid, excessive, and/or fatal hypotensive crises.

Option C: It exhibits the action of having a delayed onset, narrow therapeutic window, need for regular monitoring and INR testing, and numerous drug-drug and drug-food interactions, which limits its effective use for stroke prevention.

Option D: It is used for the prevention and management of angina pectoris caused by coronary artery disease, but its onset of action is not rapid enough to offset an acute anginal episode.

" A

4055 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CC1=CC(=O)C2=CC=CC=C2C1=O

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: Its supplements have been banned by the FDA because of their high toxicity.

Option B: It has direct actions on blood vessels and increases cardiac output.

Option C: It is commonly associated with serum enzyme elevations during therapy and to rare instances of clinically apparent acute liver injury.

Option D: It provides a totally novel mode of action with potential importance for diseases associated with ageing of the brain.

" A

151166 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CC1=CC(=C(C=C1)NC2=C(C=CC=C2Cl)F)CC(=O)O

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: It has direct actions on blood vessels and increases cardiac output.

Option B: It may cause liver failure.

Option C: It provides a totally novel mode of action with potential importance for diseases associated with ageing of the brain.

Option D: It causes relaxation of smooth muscle in blood vessels and the prostate.

" B

2733526 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CC/C(=C(\\C1=CC=CC=C1)/C2=CC=C(C=C2)OCCN(C)C)/C3=CC=CC=C3

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: It is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity.

Option B: It has multiple actions, including activating GABA(B) receptors, enhancing NMDA current, blocking AMPA-receptor-mediated transmission, binding to the L-alpha-amino acid transporter, activating ATP-sensitive K(+) channels, activating hyperpolarization-activated cation channels, and modulating Ca(2+) current.

Option C: It exhibits the action of mediating at least some of its immunomodulatory actions via inhibition of cyclic adenosine monophosphate (cAMP)-phosphodiesterase (PDE), and consequential increase in intracellular cAMP concentrations.

Option D: It interacts with other coactivators or corepressors in the tissue and binds with different estrogen receptors, ER-alpha or ER-beta.

" D

25154714 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CC(C)[C@@H](C(=O)N1CCC[C@H]1C2=NC=C(N2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C(N5)[C@@H]6CCCN6C(=O)[C@H](C(C)C)NC(=O)OC)NC(=O)OC

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: It interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme.

Option B: It prevents RNA replication and virion assembly via binding to NS5A, a nonstructural phosphoprotein encoded by HCV.

Option C: It has systemic protective, curative, and eradicant action.

Option D: It has cardiac stimulant action without evoking vasoconstriction or tachycardia.

" B

2266 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: C(CCCC(=O)O)CCCC(=O)O

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: It inhibits microbial cellular protein synthesis.

Option B: It inhibits DNA synthesis.

Option C: It interferes with bacterial protein synthesis.

Option D: It inhibits bacterial protein synthesis.

" A

24934 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: [O-][Se](=O)[O-].[Na+].[Na+]

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: It provides a totally novel mode of action with potential importance for diseases associated with ageing of the brain.

Option B: It is very irritating to skin and mucous membranes and has keratolytic actions.

Option C: It cancels out the green color imparted by iron impurities.

Option D: It undergoes biotransformation to form the active moiety for antifungal actions.

" C

2833 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: It causes premature chain termination during translation taking place in the ribosome.

Option B: It interacts with 14-alpha demethylase.

Option C: It may be at least partially involved in a certain action.

Option D: It inhibits DNA synthesis and interacts with SH groups.

" C

34328 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: C1CN(CCC1(C2=CC=CC=C2)C(=O)O)CCC(C#N)(C3=CC=CC=C3)C4=CC=CC=C4

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: It first acts on the mu-opioid receptors.

Option B: It activates opioid receptors in the intestine.

Option C: It selectively inhibits mitosis and cell division.

Option D: It interacts predominantly with the opioid mu-receptors.

" B

5281081 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CCN(CC)C(=O)/C(=C/C1=CC(=C(C(=C1)O)O)[N+](=O)[O-])/C#N

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: It has direct actions on blood vessels and increases cardiac output.

Option B: It can inhibit phosphodiesterases and may have direct actions on calcium channels.

Option C: It can act on both N-type and L-type calcium channels.

Option D: It can increase and sustain plasma levodopa concentrations.

" D

446157 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CC(C)C1=NC(=NC(=C1/C=C/[C@H](C[C@H](CC(=O)O)O)O)C2=CC=C(C=C2)F)N(C)S(=O)(=O)C

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: It has less risk of drug-drug interactions compared to certain other drugs.

Option B: It has reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug interactions.

Option C: It exhibits the action of having a delayed onset, narrow therapeutic window, need for regular monitoring and INR testing, and numerous drug-drug and drug-food interactions, which limits its effective use for stroke prevention.

Option D: It exhibits the action of having a reduced propensity for involvement in drug-drug interactions owing to its primarily reductive metabolism.

" A

5610 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: C1=CC(=CC=C1CCN)O

Question about this molecule: Which kind of action does this molecule have/exhibit?

Option A: It has cardiac stimulant action without evoking vasoconstriction or tachycardia.

Option B: It exhibits the actions of being an extremely potent uncoupler of oxidative phosphorylation in mitochondria and having high reactivity with thiols.

Option C: It can cause hypertensive crisis when ingested with tyramine-rich diet.

Option D: It is used for the prevention and management of angina pectoris caused by coronary artery disease, but its onset of action is not rapid enough to offset an acute anginal episode.