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36196367

Coping efficacy is associated with the domain specificity in risk-taking behaviors during the COVID-19 pandemic.

The current study is to explore the associations between the threat to life and risk-taking behaviors across different domains during the coronavirus disease (COVID-19), and the role of the perceived threat and coping efficacy in these associations based on protection motivation theory. This study conducted an online survey on 2983 participants from 30 provinces in China. It found that people's risk-taking behaviors in the wake of the COVID-19 pandemic could be divided into stimulating risk-taking (SRT) behaviors and instrumental risk-taking (IRT) behaviors. The exposure level to the COVID-19 pandemic was negatively related to SRT behaviors in natural/physical, gambling, safety, moral, and reproductive domains, but not related to IRT behaviors in financial and petition domains. Two parallel routes were found in domain-specific risk-taking behaviors when people were faced with a life-threatening epidemic. Specifically, perceived threat consistently mediated the positive relationship between exposure level and risk-taking behaviors across domains. In contrast, coping efficacy mediated the negative relationship between exposure level and SRT behaviors but positive associations with IRT behaviors. These findings indicated that coping efficacy, rather than perceived threat is the factor that explains the people's domain-specific risk-taking behaviors in the context of the epidemic. The study holds implications for emergency policy-making that targets disaster risk reduction by increasing the public coping efficacy, which could prevent unnecessary SRT behaviors and improve necessary IRT behaviors in business and investment for economic recoveries.

36196363

The current state of glioma data registries.

The landscape of glioma research has evolved in the past 20 years to include numerous large, multi-institutional, database piling either clinical data on glioma patients, molecular data on glioma specimens, or bination of both. While these strategies can provide a wealth of information for glioma research, obtaining information regarding data availability and access specifications can be challenging.

36196364

T cell receptor dynamic and transcriptional determinants of T cell expansion in glioma-infiltrating T cells.

Glioblastoma (GBM) is characterized by low numbers of glioma-infiltrating lymphocytes (GIL) with a dysfunctional phenotype. Whether this dysfunctional phenotype is fixed or can be reversed upon

36196368

An ensemble LSTM-based AQI forecasting model with decomposition-reconstruction technique via CEEMDAN and fuzzy entropy.

Air quality affects people's daily life. Air quality index (AQI) is an essential indicator for controlling air pollution and ensuring public health, whose accurate forecasting can provide timely air pollution warnings and remind people to take protective measures against air pollution in advance. To address this issue, this paper developed a new ensemble learning model for AQI forecasting. In this study, (1) the signal position plete ensemble empirical mode position with adaptive noise (CEEMDAN) is introduced to pose the nonlinear and nonstationary AQI history data series into several more regular and more stable subseries firstly. (2) Fuzzy entropy (FE) is selected as the feature indicator to bine the subseries with similar trends to avoid the problem of position and reduce puting time. (3) An ensemble long short-term memory (LSTM) neural network is established to forecast each reconstructed subseries, whose values are superimposed to predict the AQI value eventually. To validate the predicting performance of the proposed model, daily AQI data of Wuhan, China, dating from January 1, 2019, to February 28, 2022, is used as the experiment case. parative analysis is made between the proposed model and mon-used forecasting models. Benchmarking results of the numerical study demonstrate that the proposed model is superior to the other forecasting models with better AQI prediction accuracy.

36196369

Characterization of sabatolimab, a novel immunotherapy with immuno-myeloid activity directed against TIM-3 receptor.

Sabatolimab is a humanized monoclonal antibody (hIgG4, S228P) directed against human T-cell immunoglobulin domain and mucin domain-3 (TIM-3). Herein, we describe the development and characterization of sabatolimab.

36196370

Prevalence of inverse psoriasis subtype with immune checkpoint inhibitors.

Cutaneous immune-related adverse events (irAEs) are the mon irAEs caused by immune-checkpoint inhibitors (ICI). Psoriasiform eruptions, both

36196371

Study of the Side Effects of Pfizer and Oxford COVID-19 Vaccines in the Eastern Province of Saudi Arabia.

The COVID-19 pandemic imposed global concern and became one of the deadliest pandemics of the twenty-first century. Several vaccines were developed against SARS-CoV-2 to counteract the effects of this virus. This study aims to determine the post-vaccination side effects of the mon COVID-19 vaccines used in the Eastern province of Saudi Arabia.

36196373

Study on Chronic Obstructive Pulmonary Disease and Lung Cancer: Web of Science-Based Bibliometric and Visual Analysis.

Chronic obstructive pulmonary disease (COPD) is one of the main risk factors for lung carcinomas. This study aimed to analyze and construct a model to assess scientific publications on the relationship between COPD and lung carcinomas.

36196372

Effectiveness and Tolerability of Anlotinib Plus PD-1 Inhibitors for Patients with Previously Treated Metastatic Soft-Tissue Sarcoma.

This study was to investigate the effectiveness and tolerability of anlotinib plus PD-1 inhibitors for patients with previously treated metastatic soft tissue a (STS).

36196374

Transcatheter Atrial Septal Defect Closure Before Versus After Adulthood.

To evaluate the long-term e of patients who underwent percutaneous transcatheter closure of secundum atrial septal defects during teenage life versus adulthood.

36196376

EAGS: An extracting auxiliary knowledge graph model in multi-turn dialogue generation.

Multi-turn dialogue generation is an essential and challenging subtask of text generation in the question answering system. Existing methods focused on extracting latent topic-level relevance or utilizing relevant external background knowledge. However, they are prone to ignore the fact that relying too much on latent aspects will lose subjective key information. Furthermore, there is not so much relevant external knowledge that can be used for referencing or a graph that plete entity links. Dependency tree is a special structure that can be extracted from sentences, it covers the explicit key information of sentences. Therefore, in this paper, we proposed the EAGS model, bines the subjective pivotal information from the explicit dependency tree with sentence implicit semantic information. The EAGS model is a knowledge graph enabled multi-turn dialogue generation model, and it doesn't need extra external knowledge, it can not only extract and build a dependency knowledge graph from existing sentences, but also prompt the node representation, which is shared with Bi-GRU each time step word embedding in node semantic level. We store the specific domain subgraphs built by the EAGS, which can be retrieved as external knowledge graph in the future multi-turn dialogue generation task. We design a multi-task training approach to enhance semantics and structure local feature extraction, and balance with the global features. Finally, we conduct experiments on Ubuntu large-scale English multi-turn munity dataset and English Daily dialogue dataset. Experiment results show that our EAGS model performs well on both automatic evaluation and human pared with the existing baseline models.

36196377

Adult quality of life patterns and trajectories during the COVID-19 pandemic in Germany.

Early investigations of subjective well-being responses to the COVID-19 pandemic indicated average deterioration but also high variability related to vulnerability of population groups and pandemic phase. Thus, we aimed to gain new insights into the characteristics of certain groups and their differences in subjective well-being response patterns over time. First, we performed Latent Class Analyses with baseline survey data of 2,137 adults (mean age = 40.98,

36196378

Understanding cultural factors in mental health during the COVID-19 pandemic: when collectivism meets a tight culture.

The long-standing pathogen prevalence hypothesis suggests that collectivism can protect from epidemics and pandemics in terms of psychological well-being. However, studies exploring the protective mechanism induced when collectivism meets cultural tightness (the strength of social norms and tolerance for deviant behavior) are few. Therefore, this study aimed to investigate the protective effect of collectivism in detail considering loose and tight cultural contexts. The prised 2001 Chinese participants (

36196379

Current anxiety problems and organized activity participation among U.S. adolescents.

The study objectives were to examine the relationships between healthcare provider-confirmed current anxiety problems and organized activity participation including sports, clubs/organizations, and other activities. We used data from the 2018-2019 National Survey of Children's Health including 24,356 adolescents 12-17 years old. Poisson and logistic regression analyses were conducted. About 13% of adolescents had current anxiety problems. Poisson regression results indicated that adolescents with anxiety problems were less likely to participate in a higher total number of organized pared to children without anxiety problems. Similarly, logistic regression results indicated that adolescents with anxiety problems were at reduced odds of participating in at least one organized pared to adolescents without anxiety problems. Specific to activity type, adolescents with anxiety problems were at reduced odds of participating in sports and clubs/organizations. Study findings should be considered when creating and munity health promotion and education prevention programs and interventions for adolescents.

36196380

The Effort for Radiation Protection Increases the Value of Interventional Radiology.

Radiation protection is one of the most essential efforts for radiologists. The newest update of medical radiation protection in Japan focused on the field of interventional radiology. In this situation, it is required to choose for interventional radiologists to participate in it reluctantly or proactively. To enhance the value of interventional radiology in society, our effort mitment to learning, collaborating, and assuming our awesome responsibility is requested. We will contribute to the safety of medical facilities and society.

36196381

Successful Closure of External Iliac Artery Perforation with Super-selective Transcatheter Coil Embolization.

We present two cases of external iliac artery perforation occurring after endovascular interventions successfully treated with direct closure using super-selective transcatheter coil embolization. Two patients, one 78-year-old man and one 78-year-old woman, underwent cardiac catheterization via the right femoral approach for coronary artery disease and atrial fibrillation. Following the procedures, both patients suffered severe acute hypotension, and puted tomography revealed a massive retroperitoneal hematoma due to perforation of the right external iliac artery. We attempted direct perforation site closure with super-selective transcatheter embolization using microcoils and plete hemostasis in both cases. Our technique could be an alternative treatment option for external iliac artery perforations associated with the endovascular intervention.

36196382

Venous Rupture Following Transcatheter Arterial Embolization for Inferior Mesenteric Type II Arteriovenous Malformation.

We treated a 64-year-old man who had an inferior mesenteric arteriovenous malformation with multiple shunts. As multiple varicosities in the draining vein became enlarged, two dilated shunts on the superior rectal and sigmoid colon arteries were coil embolized. Two days after embolization, a varicosity near the shunt (65 mm diameter) ruptured, causing intra-abdominal hemorrhage and surgical hemostasis. There were thrombi in the ruptured varicosity and its draining vein. The likely cause was a pressure increase in the pletely thrombosed varicosity due to shunt blood flow from the remaining shunts after embolization.

36196383

Radiation Exposure and Protection in Computed Tomography Fluoroscopy.

Computed tomography (CT) fluoroscopy-guided procedures, such as those used for percutaneous biopsy, drainage, and radiofrequency ablation, are highly safe and quite often very successful due to the precision offered by the real-time, high-resolution tomographic images. Even so, international guidelines raised concerns regarding operator exposure to high doses of radiation during these procedures. In light of these concerns, operators conducting CT fluoroscopy-guided procedures not only need to be cognizant of the exposure risk but also exhibit sufficient knowledge of radiation protection. This paper reviews the current literature on experimental and clinical studies of radiation exposure doses to operators during CT fluoroscopy-guided procedures. In addition to the literature review, this paper also introduces different approaches that can be implemented to ensure appropriate radiation protection.

36196384

Percutaneous Transsplenic Embolization of Gastric Varices in Left-sided Portal Hypertension.

An 81-year-old man with previously diagnosed cancer of the pancreatic body presented with melena and anemia. Upper gastrointestinal endoscopy showed gastric varices with bleeding in the entire stomach. puted tomography identified a splenic vein occlusion resulting from invasion by the pancreatic body cancer and dilated collateral pathways from the splenic hilum to the gastric fundus. The patient was diagnosed with gastric varices associated with left-sided portal hypertension caused by obstruction of the splenic vein and underwent percutaneous transsplenic embolization with

36196385

Combined Transhepatic and Transsplenic Recanalization of Chronic Portal Vein Occlusion to Treat Jejunal Varices: A Report of Two Cases.

We report two cases of chronic portal vein occlusion with jejunal varices successfully treated using percutaneous intervention with bined transhepatic and transsplenic approach. Case 1 was a 60-year-old man with uncontrolled jejunal variceal bleeding, and case 2 was a 79-year-old man with anastomotic jejunal variceal bleeding and cholangitis. Single access via the transhepatic or transsplenic route failed to allow catheter advancement through the occlusion. After introducing pull-through access via the transhepatic and transsplenic routes, a metallic stent was could be used to dilate the occluded portal vein. Anastomotic jejunal varices functioning as hepatopetal collaterals were embolized after the establishment of antegrade portal flow. No symptom relapse was observed during the follow-up period (31 months for case 1 and 34 months for case 2).

36196386

Practical Radiation Protection for Interventional Radiologist.

As per the International Commission on Radiological Protection 2010 mendation, it was stated that "interventional radiologists performing difficult procedures with high workloads may be exposed to high doses" and that education and training of medical staffs in radiation exposure is "an urgent priority." There are many reports on the textbook aspects of radiation protection, but reports on the practical aspects of radiation protection have remained to be scarce. Various methods of reducing radiation exposure are described as "useful" or "can be reduced," but the priority of these methods and the "extent" to which they contribute to reducing radiation exposure are not clear. Thus, in this article, we will look into the protection of interventional radiologist from radiation exposure in a practical way, giving priority to clarity rather than academic accuracy.

36196387

Radiation Protection of the Eye Lens in Fluoroscopy-guided Interventional Procedures.

The medical staff involved in fluoroscopy-guided procedures are at potential risks of radiation-induced cataract. Therefore, proper monitoring of the lens doses is critical, and radiation protection should be provided to the maximum extent that is reasonably achievable. The collar dosimeter is necessary to avoid underestimation of the lens dose, and the third dosimeter behind the protective eyewear would be helpful for those who are likely to exceed the dose limit. The reduction of the patient doses will correspondingly reduce the staff doses. Proper placement of the ceiling-mounted shields and minimization of the face-to-glass gap are the keys to effective shielding. The optimization of procedures and devices that help maintain a distance from the irradiated area and to prevent the looking-up posture will substantially reduce the lens dose.

36196388

Dosimetry of Occupational Eye Lens Dose Using a Novel Direct Eye Dosimeter, DOSIRIS, during Interventional Radiology Procedures.

In response to the mendation by the International Commission on Radiological Protection to lower the equivalent eye dose limit, the Japanese Government in April 2021 lowered the equivalent dose limit for the eye lens for occupational exposure. A considerable number of interventional radiology operators are exposed to levels above the new limit. For this reason, a need exists to more accurately evaluate eye lens dose in interventional radiology operators by using a novel direct eye dosimeter, the DOSIRIS™(IRSN, France), which is capable of measuring a 3-mm dose equivalent under protective glasses. The DOSIRIS is a thermoluminescent dosimeter that exhibits good energy dependence and better directional properties than other dosimeters. Dosimetry using DOSIRIS might be accurate patible with the latest regulations.

36196389

Successful Treatment of Subcapsular Hepatic Hemorrhage Concomitant with Diffuse Arterioportal Shunt by Transcatheter Arterial Embolization.

We present a case of subcapsular hepatic hemorrhage with a itant diffuse arterioportal shunt successfully treated with transcatheter arterial embolization. An 85-year-old man with duodenal carcinoma developed hemorrhagic shock three days after pancreaticoduodenectomy. puted tomography revealed an extensive subcapsular hepatic hematoma with extravasation. At the same time, diagnostic angiography showed innumerable foci of petechial extravasation from disrupted isolated arteries and the right inferior phrenic artery. In addition, orbid diffuse arterioportal shunt in the hematoma area was detected. We performed transcatheter arterial embolization on the peripheral side of the hepatic artery while preserving the proximal portion. Subsequently, the transcatheter arterial embolization for the right inferior phrenic artery was also performed. Complete hemostasis and occlusion of the arterioportal shunt were successful without fulminant liver failure.

36196390

How does the COVID-19 affect earnings management: Empirical evidence from China.

Using China's A-share panies from 2018 to 2020, this paper examines the impact of COVID-19 on earnings management. The results reveal that: (1) The COVID-19 shock intensifies earnings management, which is reflected in the increasing accrual-based earnings management and real earnings management. Moreover, when enterprises face a higher degree of financial constraints, this shock effect is more evident. (2) Enterprises in industries and regions where COVID-19 is more severe are more affected by the suspension of work and production caused by the epidemic prevention policies, so these enterprises choose accrual-based earnings management through accounting items rather than carrying out earnings management through real activities. (3) Further analysis finds that, enterprises with more investment opportunities have more evident earnings management caused by the COVID-19 shock. However, high-quality auditing has an inhibitory effect on accrual-based earnings management caused by the COVID-19 shock but has no inhibitory effect on real earnings management.

36196391

Individual-Level Trajectories of Religiosity during Adolescence and Their Implications for Purpose.

parison studies suggest that adolescent religiosity has been declining over recent decades; however, work is needed on individual differences in patterns of change in religiosity throughout adolescence. The current study seeks to evaluate religiosity trends for adolescents as they transition from 6

36196393

Phosphorus uptake and toxicity are delimited by mycorrhizal symbiosis in P-sensitive

Many plant species from regions with ancient, highly weathered nutrient-depleted soils have specialized adaptations for acquiring phosphorus (P) and are sensitive to excess P supply. Mycorrhizal associations may regulate P uptake at high external P concentrations, potentially reducing P toxicity. We predicted that excess P application will negatively impact species from the nutrient-depleted Jarrah forest of Western Australia and that mycorrhizal inoculation will reduce P toxicity by regulating P uptake. For seedlings of the N

36196395

Growth-limiting drought stress induces time-of-day-dependent transcriptome and physiological responses in hybrid poplar.

Drought stress negatively impacts the health of long-lived trees. Understanding the genetic mechanisms that underpin response to drought stress is requisite for selecting or enhancing climate change resilience. We aimed to determine how hybrid poplars respond to prolonged and uniform exposure to drought; how responses to moderate and more severe growth-limiting drought stresses differed; and how drought responses change throughout the day. We established hybrid poplar trees (

36196396

Physiological, biochemical and phytohormone responses of

The

36196397

A spectacular new species of

We have discovered a spectacular new species of frog in the genus

36196398

The preclinical pharmacological study of a novel intravenous anesthetic, ET-26 hydrochloride, in aged rats.

ET-26 hydrochloride (ET-26HCl) is a novel analogue of etomidate approved for clinical trials. However, all results from recent studies were plished in young adult animals. The objective of this study was to evaluate the efficacy and safety of ET-26HCl in aged rats.

36196399

Macrophages play a key role in tissue repair and regeneration.

Tissue regeneration after body injury has always been plex problem to resolve for mammals. In adult mammals, the repair process after tissue injury is often panied by continuous and extensive fibrosis, which leads to scars. This process has been shown to severely hinder regeneration. Macrophages, as widely distributed innate immune cells, not only play an important role in various pathological processes, but also participate in the repair process before tissue regeneration and coordinate the regeneration process after repair. This review will discuss the various forms and indispensability of macrophages involved in repair and regeneration, and how macrophages play a role in the repair and regeneration of different tissues.

36196400

Mode-specific effects of concentric and eccentric isokinetic training of the hamstring muscle at slow angular velocity on the functional hamstrings-to-quadriceps ratio-a randomized trial.

Previous studies have examined the mode specificity of eccentric and concentric isokinetic training, but have reported conflicting results. Few studies have reported that eccentric and concentric isokinetic training are mode-specific,

36196402

Evaluation of total immunoglobulin G and subclass antibodies in an enzyme-linked immunosorbent assay for serodiagnosis of human amebic liver abscess.

Amebic liver abscess (ALA) caused by

36196403

Mutualist- and antagonist-mediated selection contribute to trait diversification of flowers.

Flowers are generally short-lived, and they all face a multidimensional challenge because they have to attract pel them to vector pollen with minimal investment in rewards, and repel floral enemies during this short time window. Their displays are plex selection, either consistent or conflicting, to maximize reproductive fitness under heterogeneous environments. The phenological or morphological mismatches between flowers and visitors will influence petition, resource access, mating success and, ultimately, population munity dynamics. To better understand the effects of the plant visitors on floral traits, it is necessary to determine the functional significance of specific floral traits for the visitors; how plants respond to both mutualists and antagonists through adaptive changes; and to evaluate the net fitness effects of biological mutualisms and antagonism on plants. In this review, we bring together insights from fields as diverse as floral biology, insect behavioral responses, and evolutionary biology to explain the processes and patterns of floral diversity evolution. Then, we discuss the ecological significance of plant responses to mutualists and antagonists from munity perspective, and propose a set of research questions that can guide the research field to integrate studies of plant defense and reproduction.

36196404

The validity and reliability of the Test of Memory Strategies among Italian healthy adults.

Previous literature has shown that executive functions (EF) are related to performance in memory (M) tasks. Nevertheless, there is a shortage of psychometric tests that examine these two constructs simultaneously. The Test of Memory Strategies (TMS; previously validated in Spain and Portugal) could be a useful verbal learning task that evaluates these two constructs at once. In this study, we aimed to evaluate the psychometric properties of the TMS in an Italian adult sample.

36196405

Tolerability in Glaucoma Patients Switched from Preserved to Preservative-Free Prostaglandin-Timolol Combination: A Prospective Real-Life Study.

To evaluate the effect of switching from preserved prostaglandin analog-timolol binations (PG-timolol FCs) to preservative-free latanoprost-timolol FC (PF-LT) on intraocular pressure (IOP), ocular surface health, and tolerability in a and ocular hypertension (OH) patients with the concurrent ocular surface disease (OSD).

36196406

Retinitis Pigmentosa in the Puerto Rican Population: A Geographic Distribution.

Previous studies have reported on retinitis pigmentosa (RP) in Puerto Rico. Information on the geographic distribution of RP mutations in Puerto Rico may lead to higher rates of diagnosis and co-management. We aimed to evaluate whether there are areas with increased incidence of genes leading to RP in the Island.

36196407

Integrated scoring approach to assess radiotherapy plan quality for breast cancer treatment.

Proposal of an integrated scoring approach assessing the quality of different treatment techniques in a radiotherapy parison. This scoring method incorporates all dosimetric indices of planning target volumes (PTVs) as well as organs at risk (OARs) and provides a single quantitative measure to select an ideal plan.

36196408

The outcome of radiation therapy as a primary treatment in orbital lymphoma: a systematic review.

The extranodal marginal-zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT) is the mon orbital and adnexal lymphomas. Radiotherapy is one of the most preferred treatment options for orbital lymphomas since they are localized and radiation sensitive. The objective of this study is to evaluate how radiation therapy affected the e of orbital MALT lymphoma.

36196409

Thyroid function following radiation therapy in breast cancer patients: risk of radiation-induced hypothyroidism.

Radiation exposure to the thyroid gland seems unavoidable in breast cancer (BC) patients receiving radiation therapy (RT) to the supraclavicular (SC) region. Hence, this study aimed to evaluate the effects of SC region RT on thyroid function and the prevalence of radiation-induced hypothyroidism (RIHT) in BC patients at regular intervals post-treatment.

36196410

Treatment-integrated imaging, radiomics, and personalised radiotherapy: the future is at hand.

Since the introduction puted tomography for planning purposes in the 1970s, we have been observing a continuous development of different imaging methods in radiotherapy. The current achievements of imaging technologies in radiotherapy enable more than just improvement of accuracy on the planning stage. Through integrating imaging with treatment machines, they allow advanced control methods of dose delivery during the treatment. This article reviews how the integration of existing and novel forms of imaging changes radiotherapy and how these advances can allow a more individualised approach to cancer therapy. We believe that the significant challenge for the next decade is the continued integration of a range of different imaging devices into linear accelerators. These imaging modalities should show intra-fraction changes in body morphology and inter-fraction metabolic changes. As the use of these more advanced, integrated machines grows, radiotherapy delivery will e more accurate, thus resulting in better clinical es: higher cure rates with fewer side effects.

36196411

Intraoperative radiation therapy for early-stage breast cancer: a single-institution experience.

To assess es and toxicity after low-energy intraoperative radiotherapy (IORT) for early-stage breast cancer (ESBC).

36196412

Examination of the dose distribution of volumetric modulated arc radiotherapy using a high-definition multi-leaf collimator for breast cancer patients with irradiated regional lymph nodes.

A high-definition multi-leaf collimator (HD-MLC) with 5- and 10-mm fine MLCs is useful for radiotherapy. However, it is difficult to irradiate the mammary gland and supraclavicular region using a HD-MLC because of the narrow field of volumetric modulated arc radiotherapy (VMAT). Therefore, we aimed to evaluate the dose distribution of the VMAT dose using a HD-MLC in 15 patients with left breast cancer undergoing postoperative irradiation of breast and regional lymph nodes, including the internal mammary node.

36196413

Anatomy-based prediction method for determining ipsilateral lung doses in postoperative breast radiation therapy assisted by diagnostic computed tomography images.

This study aimed to investigate whether ipsilateral lung doses (ILDs) could be predicted by anatomical indexes measured using puted tomography (CT) prior to the planning stage of breast radiation therapy (RT).

36196414

Biochemical failure and toxicity in treatment with brachytherapy and external beam radiotherapy compared with radical prostatectomy in localized prostate cancer.

Localized prostate cancer (T1-3N0M0) has therapeutic options such as radical prostatectomy (RP), external beam radiation therapy (EBRT) and brachytherapy (BT). However, the evidence of the e of these treatments is limited and no studies have been paring biochemical failure (BF) and toxicity associated with surgical treatment and EBRT + high-dose brachytherapy (HDBT) in the region.

36196415

A dosemetric and radiobiological impact of VMAT and 3DCRT on lumbosacral plexuses, an underestimated organ at risk in cervical cancer patients.

The purpose of this study was to evaluate dosimetric and radiobiological difference between volumetric modulated arc therapy (VMAT) and 3-dimensional conformal radiotherapy (3DCRT) in organ at risk (OAR) lumbosacral plexus (LSP) in cervical cancer patients.

36196416

Glioblastoma - treatment and obstacles.

Glioblastoma is the mon and aggressive primary tumor in adults. A narrative review of all the relevant papers known was conducted.

36196419

Evaluation of results and costs of high precision radiotherapy (VMAT) compared with conventional radiotherapy (3D) in the treatment of cancer patients with spinal cord compression of metastatic origin.

The aim of this study was to evaluate the results and economic costs of using volumetric modulated arc therapy (VMAT) (5 fr × 5 pared with other conventional 3D radiotherapy schemes such as "5 × 4 Gy" and "10 × 3 Gy".

36196418

Bone health assessment with dual energy X-ray absorptiometry in men with high-risk prostate carcinoma commencing adjuvant androgen deprivation therapy.

Androgen deprivation therapy (ADT) is a ponent of therapy for patients with high-risk prostate carcinoma, but it may be deleterious for bone health. We sought to determine the frequency of dual energy x-ray absorptiometry (DXA) scanning in mencing adjuvant ADT for treatment of high-risk prostate cancer at a large integrated regional cancer centre.

36196420

Prognostic factors for post-recurrence survival among patients with locally advanced cervical cancer who underwent definitive concurrent chemoradiation.

The prognostic factors affecting post-recurrence survival (PRS) in patients with locally advanced cervical cancer (LACC) who receive concurrent chemoradiation (CCRT) are not well established. This study aimed to assess the prognostic factors for PRS in patients with recurrent LACC who underwent CCRT as the primary treatment.

36196421

Treatment of benign tumours and related pathologies with radiotherapy: experience of the General Hospital of Mexico.

Benign diseases include tumours or localized growths with low potential for progression. The use of radiotherapy (RT) at a low dose (LD) or intermediate dose for benign pathologies has been widely proposed and studied. Currently, the use of RT is limited mainly to hyperproliferative and inflammatory diseases as a first or second line of treatment.

36196422

Impact of COVID-19 on the curative treatment of prostate cancer: a national cross-sectional study.

COVID-19 pandemic affected access to cancer treatment worldwide. However, there is a lack of data about the impact in developing countries. The objective was to evaluate COVID-19 impact on curative prostate cancer (Pca) treatment in Brazil.

36196423

The use of the normal tissue non-complication probability (NTCP0) methodology as a new alternative of assessing side-effects in brachytherapy treatments.

The NTCP methodology evaluating side-effects (S-Es) was initially used in radiotherapy (RT), and later was extended to brachytherapy (BT). The NTCP0 methodology has been recently introduced in RT. Given the advantages, this methodology could replace NTCP.

36196424

Repeat single-fraction stereotactic radiosurgery for recurrent vestibular schwannoma.

Data are scarce on the efficacy of a second radiosurgery (SRS) treatment of vestibular schwannoma that has progressed following initial treatment with SRS. We sought to report the e of our repeat SRS series with long-term imaging follow-up.

36196425

Radiosurgery for multiple brain metastases using volumetric modulated arc therapy: a single institutional series.

Patients with brain metastases (BM) live longer due to improved diagnosis and oncologic treatments. The association of volumetric modulated arc therapy (VMAT) and image-guided radiation therapy (IGRT) with brain radiosurgery (SRS) plex dose distributions and faster treatment delivery to multiple lesions.

36196427

Deep inspiration breath hold in post-operative radiotherapy for right breast cancer: a retrospective analysis.

The aim of our study is to determine whether deep inspiration breath hold (DIBH) is effective for reducing exposure of the heart, left coronary artery (LAD) and both lungs in right breast radiotherapy.

36196428

Profile of Secondary Bacterial and Fungal Infections in Hospitalized COVID-19 Patients in a Tertiary Care Centre.

SARS CoV-2, a novel corona virus, has emerged in December 2019. The COVID-19 associated mortality is documented in elderly with co morbidities. To have better insight on this issue, the secondary bacterial infections with multi-drug-resistant bacteria in COVID-19 patients need to be studied to evaluate the impact of these infections on the e.

36196429

Ratiometric fluorescent Si-FITC nanoprobe for immunoassay of SARS-CoV-2 nucleocapsid protein.

Coronavirus disease 2019 (COVID-19) highlights the importance of rapid and reliable diagnostic assays for the management of virus transmission. Here, we developed a one-pot hydrothermal method to prepare Si-FITC nanoparticles (NPs) for the fluorescent immunoassay of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid protein (N protein). The synthesis of Si-FITC NPs did not need post-modification, which addressed the issue of quantum yield reduction during the coupling reaction. Si-FITC NPs showed two distinct peaks, Si fluorescence at

36196430

Equivalent Formulations of Optimal Control Problems with Maximum Cost and Applications.

We revisit the optimal control problem with maximum cost with the objective to provide different equivalent reformulations suitable to numerical methods. We propose two reformulations in terms of extended Mayer problems with state constraints, and another one in terms of a differential inclusion with upper-semi-continuous right member without state constraint. For the latter we also propose a scheme that approximates from below the optimal value. These approaches are illustrated and discussed in several examples.

36196432

Measuring Support for Women's Political Leadership: Gender of Interviewer Effects Among African Survey Respondents.

Public opinion surveys are a fundamental tool to measure support for women's political rights. This article focuses on perceptions of women's suitability for leadership. To what extent do influential cross-country surveys that include such items suffer from measurement errors stemming from gender of interviewer effects? Building on the literature on social desirability, we expect that respondents are more likely to express preference for men's suitability as political leaders with male interviewers and more likely to state support for women's leadership when interviewed by a woman. We hypothesize that these processes are conditioned by having one's spouse present, by age differences between respondents and interviewers, as well as by respondents' levels of education. Analyzing Afrobarometer data, we generally find support for our claims. In addition, it seems that men are slightly more affected by such effects than women are. These gender of interviewer effects persist when analyzing alternative survey rounds and are insensitive to various fixed effects specifications and robustness tests. For the analysis of survey data, we suggest that researchers using gender-related items should control for gender of interviewer effects. We propose parative survey programs pay even more attention to interviewer characteristics and the interview situation in their protocols.

36196433

The Domestic Impact of International Shaming: Evidence from Climate Change and Human Rights.

Do international shaming efforts affect citizens' support for government policies? While it is a frequent claim in the literature that shaming works through domestic politics, we know little about how and when international criticism affects domestic public opinion. We address this question through an originally designed survey experiment in Sweden, which pares the effects of international shaming in two issue areas-human rights and climate change, and (ii) tests whether government responses to criticism moderate the impact of shaming. Our main findings are fourfold. First, we find substantial effects of international shaming on domestic public opinion. These effects hold across both issue areas and irrespective of whether citizens support government parties or not. Second, human rights shaming has a stronger impact on citizens' support for government policies than climate shaming. Third, shaming is most effective among citizens who are more supportive of climate action, human rights, and international cooperation. Finally, our findings are mixed with respect to the effect of government responses. While government responses do not moderate the effects of human rights shaming, they seem to mitigate the effects of climate shaming.

36196434

Effects of Preconditioning on RBC Deformability in Critically Ill Patients.

RBCs from critically ill patients have depressed deformability, especially in sepsis. Prolonged exposure of RBCs from healthy volunteers to physiologic shear stress (the preconditioning technique) has been associated with improved deformability, but the effect of preconditioning on RBCs from critically ill patients with or without sepsis has never been studied.

36196435

Screening for Social Risk Factors in the ICU During the Pandemic.

Due to limitations in data collected through electronic health records, the social risk factors (SRFs) that predate severe illness and restrict access to critical care services are poorly understood.

36196431

Trauma Pancreático Penetrante Severo-Revisión Retrospectiva de Una Serie de Casos Manejados Con Una Estrategia Simplificada en un Centro de Trauma Nivel 1.

Pancreatic trauma has a low incidence in both closed and penetrating injuries. The risk for morbidity and mortality is associated with injury severity of multiple organ injuries.

36196436

Bariatric surgery outcomes following organ transplantation: A review study.

Weight gain is a frequent plication following a solid organ transplant which can be solved by bariatric surgery. The es of bariatric surgery among patients with an organ transplant history are always a challengeable subject for surgeons and surgery candidates. In this review article, we aim to investigate the existence literature about the rates of morbidity and mortality, plications in terms of graft function, remission in diabetes, hypertension, pulmonary and cardiovascular disorders, hepatic and renal functions, and immunosuppressive stability, as well as the safety of bariatric surgery among patients.

36196437

Diet and nutrition against inflammatory bowel disease: Trick or treat(ment)?

Even if the relationships between nutrition and inflammatory bowel disease (IBD) remain underexplored, the current literature is providing, day by day, much more evidence on the effects of various diets in both prevention and treatment of such illnesses. Wrong dietary habits, together with other environmental factors such as pollution, breastfeeding, smoke, and/or antibiotics, are among the theoretical pathogenetic causes of IBD, whose multifactorial aetiology has been already confirmed. While some of these risk factors are potentially reversible, some others cannot be avoided, and efficient treatments e necessary to prevent IBD spread or recurrence. Furthermore, the drugs currently available for treatment of such disease provide low-to-no effect against the symptoms, making the illnesses still strongly disabling. Whether nutrition and specific diets will prove to effectively interrupt the course of IBD has still to be clarified and, in this sense, further research concerning the applications of such dietary interventions is still needed.

36196438

Performance of a serological IgM and IgG qualitative test for COVID-19 diagnosis: An experimental study in Brazil.

Qualitative antibody tests are an easy, point-of-care diagnostic method that is useful in diagnosing coronavirus disease 2019, especially in situations where reverse transcription-polymerase chain reaction is negative. However, some factors are able to affect its sensitivity and accuracy, which may contribute to these tests not being used as a first-line diagnostic tool.

36196439

Activity of meropenem/vaborbactam and comparators against non-carbapenemase-producing carbapenem-resistant Enterobacterales isolates from Europe.

Carbapenem-resistant Enterobacterales (CRE) isolates have disseminated worldwide. CREs usually produce a carbapenemase; however, some isolates are negative for known carbapenemases. In this study, we evaluated the activity of meropenem/vaborbactam parators against CREs without a carbapenemase (nonCP CREs) collected from European hospitals from 2016 to 2019.

36196440

Antimicrobial susceptibility and neonatal sepsis in a tertiary care facility in Nigeria: a changing trend?

Neonatal sepsis remains one of the leading causes of morbidity and mortality in neonates, especially in developing countries.

36196441

Antibiotic prescribing amongst South African general practitioners in private practice: an analysis of a health insurance database.

To investigate the appropriateness of antibiotic prescribing among GPs in the private primary healthcare sector in South Africa.

36196442

Determining the

Antimicrobials for bloodstream infections due to ESBL- and AmpC-producing

36196443

Gaps and barriers in the implementation and functioning of antimicrobial stewardship programmes: results from an educational and behavioural mixed methods needs assessment in France, the United States, Mexico and India.

Evidence shows limited adherence to antimicrobial stewardship (AMS) principles.

36196444

Prevalence of carbapenemase genes among carbapenem-nonsusceptible

To evaluate the prevalence of acquired β-lactamase genes and susceptibility profiles of carbapenem-nonsusceptible

36196445

A retrospective study of

A synergistic bination of a penicillin and gentamicin (AG) or ceftriaxone (AC) is used in the management of

36196448

Knee meniscus regeneration using autogenous injection of uncultured adipose tissue-derived regenerative cells.

The low healing potential of mature menisci necessitates traditional surgical removal (meniscectomy) to eliminate acute or chronic degenerative tears. However, removal of meniscal tissue is main factor causing osteoarthritis. Adipose tissue-derived regenerative cells (ADRCs), a heterogeneous cell population that includes multipotent adipose-derived stem cells and other progenitor cells, were easily isolated in large amounts from autologous adipose tissue, and same-day processing without culture or expansion was possible. This study investigated the regenerative potential of autologous ADRCs for use in meniscus defects.

36196447

Pathogenesis and potential therapeutic application of stem cells transplantation in Huntington's disease.

Huntington's disease (HD) is a progressive neurodegenerative disorder which is caused due to repetitive CAG or glutamine expression along the coding region of the Huntington gene. This disease results in certain movement abnormalities, affective disturbances, dementia and cognitive impairments. To this date, there is no proper cure for this rare and fatal neurological condition but there have been certain advancements in the field of genetic animal model research studies to elucidate the understanding of the pathogenesis of this condition. Currently, HD follows a certain therapeutic approach which just relieves the symptoms but doesn't cure the underlying cause of the disease. Stem cell therapy can be a breakthrough in developing a potential cure for this condition. In this review, we have discussed the pathogenesis and the efficacy and clinical practicality of the therapeutic application of stem cell transplantation in Huntington's disease. The application of this groundbreaking therapy on genetically altered animal models has been listed and analyzed in brief.

36196449

Efficient reprogramming of human fibroblasts using RNA reprogramming with DAPT and iDOT1L under normoxia conditions.

Human induced pluripotent stem cells (hiPSCs) are generated through the reprogramming of somatic cells expressing a defined set of transcription factors. The advent of autologous iPSCs has enabled the generation of patient-specific iPSC lines and is expected to contribute to the exploration of cures and causes of diseases, drug screening, and tailor-made regenerative medicines. Efficient control of hiPSC derivation is beneficial for industrial applications. However, the mechanisms underlying somatic cell reprogramming remain unknown, while reprogramming efficiency remains extremely low, especially in human cells.

36196450

Time-frequency co-movement and risk connectedness among cryptocurrencies: new evidence from the higher-order moments before and during the COVID-19 pandemic.

ovements and connectedness is critical for providing significant implications for crypto-portfolio risk management. However, most existing research focuses on the lower-order moment nexus (i.e. the return and volatility interactions). For the first time, this study investigates the higher-order ovements and risk connectedness among cryptocurrencies before and during the COVID-19 pandemic in both the time and frequency domains. bine the realized moment measures and wavelet coherence, and the newly proposed time-varying parameter vector autoregression-based frequency connectedness approach (Chatziantoniou et al. in Integration and risk transmission in the market for crude oil a time-varying parameter frequency connectedness approach. Technical report, University of Pretoria, Department of Economics, 2021) using intraday high-frequency data. The empirical results demonstrate that ovement of realized volatility between BTC and other cryptocurrencies is stronger than that of the realized skewness, realized kurtosis, and signed jump variation. ovements among cryptocurrencies are both time-dependent and frequency-dependent. Besides the volatility spillovers, the risk spillovers of high-order moments and jumps are also significant, although their magnitudes vary with moments, making them moment-dependent as well and are lower than volatility connectedness. Frequency connectedness demonstrates that the risk connectedness is mainly transmitted in the short term (1-7 days). Furthermore, the total dynamic connectedness of all realized moments is time-varying and has been significantly affected by the outbreak of the COVID-19 pandemic. Several practical implications are drawn for crypto investors, portfolio managers, regulators, and policymakers in optimizing their investment and risk management tactics.

36196451

A Bayesian-based classification framework for financial time series trend prediction.

Financial time series have been extensively studied within the past decades; however, the advent of machine learning and deep neural networks opened new horizons to apply puting techniques to extract more insights from the underlying patterns of price data. This paper presents a tri-state labeling approach to classify the underlying patterns in price data into up, down and no-action classes. The introduction of a no-action state in our novel approach alleviates the burden of denoising the dataset as a preprocessing task. The performance of our labeling algorithm is experimented with using machine learning and deep learning models. The framework is augmented by applying the Bayesian optimization technique for the selection of the best tuning values of the hyperparameters. The price trend prediction module generates the required trading signals. The results show that the average annualized Sharpe ratio as the trading performance metric is about 2.823, indicating the framework produces excellent cumulative returns.

36196452

[Adverse reactions to drugs used for COVID-19 in five Latin American countriesReações adversas a medicamentos utilizados para a COVID-19 em cinco países da América Latina].

Characterize and describe reports of suspected adverse reactions to a group of drugs used in Colombia, Costa Rica, Cuba, Chile, El Salvador, Mexico, and Peru to treat or prevent coronavirus disease (COVID-19) between 1 March and 31 August 2020.

36196454

Spatio-temporal analysis of air quality and its relationship with COVID-19 lockdown over Dublin.

Air pollution has e one of the biggest challenges for human and environmental health. Major pollutants such as Nitrogen Dioxide (NO

36196455

Skin hyperpigmentation after sclerotherapy with polidocanol: A systematic review.

Skin hyperpigmentation after sclerotherapy with polidocanol-containing sclerosants is mon local side effect. Sclerotherapists should be familiar with factors that trigger hyperpigmentation after sclerotherapy with polidocanol-containing sclerosants. A systematic literature review of works reporting hyperpigmentation after sclerotherapy for telangiectasias, reticular veins, side branches and truncal varices with polidocanol-containing sclerosants was performed. Reported incidence rates, follow-up periods and potentially triggering factors were assessed and analysed. The search yielded 1687 results; of these, 27 reports met the inclusion criteria. The incidence of hyperpigmentation seemed to increase with higher concentrations of polidocanol and was more evident after sclerotherapy for epifascial veins than for intrafascial truncal veins when the polidocanol concentration was more than 0.25%. Regarding sclerotherapy for telangiectasias and reticular veins, the incidence of hyperpigmentation ranged between 2% and 25% for polidocanol 0.25% (liquid and foam), between 12.5% and 67.9% for polidocanol 0.5% (liquid and foam) and between 13% and 73% for polidocanol 1% (liquid and foam). Regarding truncal veins, the incidence ranged from 7% to 45.8% for polidocanol 1% (liquid and foam), from 16% to 17% for polidocanol 2% (foam) and from 7.4% to 32.5% for polidocanol 3% (liquid and foam). Regarding the treatment of side branches, the incidence of hyperpigmentation ranged from 5.6% to 53% for both foam and liquid sclerotherapy. Regarding the duration of hyperpigmentation, there are few data describing reticular veins and telangiectasias. Hyperpigmentation persisting for more than 6 months has been reported to have an incidence of up to 7.5%. Hyperpigmentation persisting for more than 1 year after foam polidocanol 1%-3% treatment for truncal veins has an incidence ranging from 8.1% to 17.5%. Other factors such as higher volumes pression therapy after treatment seem to have a minor influence. Data regarding hyperpigmentation after polidocanol-related sclerotherapy are poor and should be improved by higher-quality research.

36196456

Long non-coding RNA FABP5P3/miR-22 axis improves TGFβ1-induced fatty acid oxidation deregulation and fibrotic changes in proximal tubular epithelial cells of renal fibrosis.

Severe hydronephrosis increases the risk of urinary tract infection and irretrievable renal fibrosis. While TGFβ1-mediated fibrotic changes in proximal tubular epithelial cells and fatty acid oxidation (FAO) deregulation contribute to renal fibrosis and hydronephrosis. Firstly, a few elements were analyzed in this paper, including differentially-expressed long non-coding RNAs (lncRNAs), and miRNAs correlated to CPT1A, RXRA, and NCOA1. This paper investigated TGFβ1 effects on lncRNA FABP5P3, CPT1A, RXRA, and NCOA1 expression and fibrotic changes in HK-2 cells and FABP5P3 overexpression effects on TGFβ1-induced changes. Moreover, this paper predicted and proved that miR-22 binding to lncRNA FABP5P3, 3'UTR of CPT1A, RXRA, and NCOA1 was validated. The dynamic effects of the FABP5P3/miR-22 axis on TGFβ1-induced changes were investigated. A Renal fibrosis model was established in unilateral ureteral obstruction (UUO) mice, and FABP5P3 effects were investigated. Eventually, this paper concluded that TGFβ1 inhibited lncRNA FABP5P3, CPT1A, RXRA, and NCOA1 expression, induced fibrotic changes in HK-2 cells, and induced metabolic reprogramming within HK-2 cells, especially lower FAO. FABP5P3 overexpression partially reversed TGFβ1-induced changes. miR-22 targeted lncRNA FABP5P3, CPT1A, RXRA, and NCOA1. LncRNA FABP5P3 counteracted miR-22 inhibition of CPT1A, NCOA1, and RXRA petitive binding. TGFβ1 stimulation induced the activation of TGFβ/SMAD and JAG/Notch signaling pathways; Nocth2 knockdown reversed TGFβ1 suppression on lncRNA FABP5P3. FABP5P3 overexpression attenuated renal fibrosis in unilateral ureteral obstruction mice. The LncRNA FABP5P3/miR-22 axis might be a potent target for improving the FAO deregulation and fibrotic changes in proximal TECs under TGFβ1 stimulation.

36196458

Building collaborative relationships with family caregivers of hospitalized older persons with delirium superimposed on dementia: A qualitative study.

To explore experiences of family caregivers providing support to older persons with delirium superimposed on dementia in acute care hospitals, their role in detection and management of this condition, and support they require.

36196459

Mothering in the context of intimate partner violence: A feminist intersectional critique of the nursing literature.

To describe how mothers and mothering in the context of IPV are conceptualized in the nursing research and practice literature with attention to underlying ideologies, biases and potential harms.

36196460

Dexmedetomidine protects cells from Angiotensin II-induced smooth muscle cell phenotype switch and endothelial cell dysfunction.

Abdominal aortic aneurysm (AAA) is a vascular disorder greatly threatening life of the elderly population. Dexmedetomidine (DEX), an α2-adrenergic receptor agonist, has been shown to suppress AAA development. Nevertheless, the signaling pathways that might be mediated by DEX in AAA has not been clarified. Vascular smooth muscle cells (VSMCs) and endothelial cells (ECs) were treated with Angiotensin II (Ang II) to mimic AAA

36196462

Association of epicardial adipose tissue with proteomics, coronary flow reserve, cardiac structure and function, and quality of life in heart failure with preserved ejection fraction: insights from the PROMIS-HFpEF study.

Epicardial adipose tissue (EAT) may play a role in the pathophysiology of heart failure with preserved ejection fraction (HFpEF). We investigated associations of EAT with proteomics, coronary flow reserve (CFR), cardiac structure and function, and quality of life (QoL) in the prospective multinational PROMIS-HFpEF cohort.

36196463

Targets and management of hypertension in heart failure: focusing on the stages of heart failure.

Hypertension is highly prevalent worldwide and is the major risk factor for heart failure (HF). More than half of the patients with HF in Asia suffer from hypertension. According to the 2022 American Heart Association/American College of Cardiology/Heart Failure Society of America HF guideline, there are four stages of HF, including at risk for HF (stage A), pre-HF (stage B), symptomatic HF (stage C), and advanced HF (stage D). Given the high prevalence of hypertension as well as HF and the stronger association between hypertension and cardiovascular diseases in pared to the west, measures to prevent and alleviate the progression to clinical HF, especially controlling the blood pressure (BP), are of priority for Asian populations. After reviewing evidence-based studies, we propose a BP target of less than 130/80 mmHg for patients at stages A, B, and C. However, relatively higher BP may represent an opportunity to maximize guideline-directed medical therapy (GDMT), which could potentially result in a better prognosis for patients at stage D. Traditional antihypertensive drugs are the cornerstones for the management of hypertension at stages A and B. Notably, calcium channel blockers (CCBs) are inferior to other drug classes for the preventing of HF, whereas diuretics are superior to others. For patients at stage C, GDMT is essential which also helps the control of BP. In particular, sodium-glucose cotransporter-2 (SGLT2) inhibitors are newer therapies mended for the treatment of HF and presumably even in hypertension to prevent HF. Regarding patients at stage D, GDMT is also mended if tolerable and measures should be taken to improve hemodynamics.

36196464

The role of renal nerve stimulation in percutaneous renal denervation for hypertension: A mini-review.

Recent trials have demonstrated the efficacy and safety of percutaneous renal sympathetic denervation (RDN) for blood pressure (BP)-lowering in patients with uncontrolled hypertension. Nevertheless, major challenges exist, such as the wide variation of BP-lowering responses following RDN (from strong response to no response) and lack of feasible and reproducible peri-procedural predictors for patient response. Both animal and human studies have demonstrated different patterns of BP responses following renal nerve stimulation (RNS), possibly related to varied regional proportions of sympathetic and parasympathetic nerve tissues along the renal arteries. Animal studies of RNS have shown that rapid electrical stimulation of the renal arteries caused renal artery vasoconstriction and increased norepinephrine secretion with a itant increase in BP, and the responses were attenuated after RDN. Moreover, selective RDN at sites with strong RNS-induced BP increases led to a more efficient BP-lowering effect. In human, when RNS was performed before and after RDN, blunted changes in RNS-induced BP responses were noted after RDN. The systolic BP response induced by RNS before RDN and blunted systolic BP response to RNS after RDN, at the site with maximal RNS-induced systolic BP response before RDN, both correlated with the 24-h ambulatory BP reductions 3-12 months following RDN. In summary, RNS-induced BP changes, before and after RDN, could be used to assess the immediate effect of RDN and predict BP reductions months following RDN. prehensive, large-scale and long term trials are needed to verify these findings.

36196465

The HOPE Asia network 2022 up-date consensus statement on morning hypertension management.

Morning hypertension is an important clinical target in the management of hypertension for perfect 24-h blood pressure (BP) control. Morning hypertension is generally categorized into two types: "morning surge" type and "sustained nocturnal and morning hypertension" type. The "morning surge" type is characterized by an exaggerated morning blood pressure surge (MBPS), and the "sustained nocturnal and morning hypertension" type with continuous hypertension from nighttime to morning (non-dipper/riser type). They can be detected by home and ambulatory blood pressure measurements (HBPM and ABPM). These two forms of morning hypertension both increase the risk of cardiovascular and renal diseases, but may occur via different pathogenic mechanisms and are associated with different conditions. Morning hypertension should be treated to achieve a morning BP level of < 135/85 mmHg, regardless of the office BP. The second target morning BP levels is < 125/75 mmHg for high-risk patients with morning hypertension and itant diseases. Morning hypertension is more frequently found in Asians, than in Westerners. Thus, the management of morning hypertension is especially important in Asia. The detection of morning hypertension and the individual home BP-guided treatment approach targeting morning BP bination with ABPM, and the optimal treatment of morning hypertension would reduce cardiovascular events in Asia.

36196467

Role of α1-blockers in the current management of hypertension.

There is emerging evidence that α1-blockers can be safely used in the treatment of hypertension. These drugs can be used in almost all hypertensive patients for blood pressure control. However, there are several special indications. Benign prostatic hyperplasia is pelling indication of α1-blockers, because of the dual treatment effect on both high blood pressure and lower urinary tract symptoms. Many patients with resistant hypertension would require α1-blockers as add-on therapy. Primary aldosteronism screen is a rapidly increasing clinical demand in the management of hypertension, where α1-blockers are useful for blood pressure control in the preparation for the measurement of plasma aldosterone and renin. Nonetheless, α1-blockers have to be used under several considerations. Among the currently available agents, only long-acting α1-blockers, such as doxazosin gastrointestinal therapeutic system 4-8 mg daily and terazosin 2-4 mg daily, should be chosen. Orthostatic hypotension is a concern with the use of α1-blockers especially in the elderly, and requires careful initial bedtime dosing and avoiding overdosing. Fluid retention is potentially also a concern, which may be e bining an α1-blocker with a diuretic.

36196468

2022 Thai Hypertension Society guidelines on home blood pressure monitoring.

In 2021, the Universal Health Coverage Payment Scheme of Thailand approved home blood pressure monitoring (HBPM) devices for reimbursement. National utilization of HBPM devices will begin in 2022. This article provides the mendations for HBPM from the Thai Hypertension Society. In this report, the authors review the benefits of HBPM and mend confirming the diagnosis of hypertension by HBPM. Devices for HBPM should be the automated and validated upper arm cuff devices. HBPM should be ideally done for seven consecutive days before each clinic visit and take at least two readings (1 min apart) in the morning and before going to bed. The average blood pressure (BP) of 125-134/75-84 mmHg is classified as high normal BP and hypertension is BP of 135/85 mmHg or more. Target BP levels depend on the age of the patients; that is, < 125/75 mmHg for patients aged 18-65 years old, and <135/85 mmHg for patients over 65 years of age.

36196469

Who should be screened for primary aldosteronism? A comprehensive review of current evidence.

Arterial hypertension is a major risk factor for cardiovascular disease. The prevalence of primary aldosteronism (PA) ranges from 5% to 10% in the general hypertensive population and is regarded as one of the mon causes of secondary hypertension. There are two major causes of PA: bilateral adrenal hyperplasia and aldosterone-producing adenoma. The diagnosis of prises screening, confirmatory testing, and subtype differentiation. The Endocrine Society Practice Guidelines for the diagnosis and treatment of PA mends screening of patients at an increased risk of PA. These categories include patients with stage 2 and 3 hypertension, drug-resistant hypertension, hypertensive with spontaneous or diuretic-induced hypokalemia, hypertension with adrenal incidentaloma, hypertensive with a family history of early onset hypertension or cerebrovascular accident at a young age, and all hypertensive first-degree relatives of patients with PA. Recently, several studies have linked PA with obstructive sleep apnea and atrial fibrillation unexplained by structural heart defects and/or other conditions known to cause the arrhythmia, which may be partly responsible for the higher rates of cardiovascular and cerebrovascular accidents in patients with PA. The aim of this review is to discuss which patients should be screened for PA, focusing not only on well-established guidelines but also on additional groups of patients with a potentially higher prevalence of PA, as has been reported in recent research.

36196470

Hypertensive emergencies in Asia: A brief review.

Hypertensive emergency is one of the most challenging conditions to treat in the emergency department (ED). From previous studies, about 1%-3% of hypertensive individuals experienced hypertensive emergencies. Its prevalence varied by country and region throughout Asia. Asian populations have more different biological and cultural backgrounds than Caucasians and even within Asian countries. However, there is a scarcity of research on clinical features, treatment, and es in multinational Asian populations. The authors aimed to review the current evidence about epidemiology, clinical characteristics and es, and practice guidelines in Asia. Five observational studies and nine clinical practice guidelines across Asia were reviewed. The prevalence of hypertensive emergencies ranged from .1% to 1.5%. Stroke was the mon target organ involvement in Asians who presented with hypertensive emergencies. Although most hypertensive emergency patients required hospitalization, the mortality rate was low. Given the current lack of data among Asian countries, a multinational data repository and Asian guidelines on hypertensive emergency management are mandatory.

36196472

Standardized home blood pressure monitoring: Rationale behind the 722 protocol.

Home blood pressure (HBP) has been recognized as a prognostic predictor for cardiovascular events, and integrated into the diagnosis and management of hypertension. With increasing accessibility of oscillometric blood pressure devices, HBP monitoring is easy to perform, more likely to obtain reliable estimation of blood pressures, and feasible to document long-term blood pressure pared to office and ambulatory blood pressures. To obtain reliable HBP estimates, a standardized HBP monitoring protocol is essential. A consensus regarding the optimal duration and frequency of HBP monitoring is yet to be established. Based on the current evidence, the "722" protocol, which stands for two measurements on one occasion, two occasions a day (morning and evening), and over a consecutive of 7 days, is monly used in clinical studies and mended in relevant guidelines and consensus documents. HBP monitoring based on the "722" protocol fulfills the minimal requirement of blood pressure measurements to achieve agreement of blood pressure classifications defined by office blood pressures and to predict cardiovascular risks. In the Taiwan HBP consensus, the frequency of repeating the "722" protocol of HBP monitoring according to different scenarios of hypertension management, from every 2 weeks to 3 months, is mended. It is reasonable to conclude that the "722" protocol for HBP monitoring is clinically justified and can serve as a basis for standardized HBP monitoring.

36196473

Highlights of the 2022 Vietnamese Society of Hypertension guidelines for the diagnosis and treatment of arterial hypertension: The collaboration of the Vietnamese Society of Hypertension (VSH) task force with the contribution of the Vietnam National Heart Association (VNHA): The collaboration of the Vietnamese Society of Hypertension (VSH) task force with the contribution of the Vietnam National Heart Association (VNHA).

Hypertension is uncontrolled in over 50% hypertensive population in Vietnam which indicated pelling need for new hypertension guidelines. The highlights posed of three parts: the diagnosis of arterial hypertension, the mendation of home blood pressure monitoring, and the treatment of hypertension. Our guideline applied flexibility based upon the "essential" and "optimal" concepts in the diagnosis and management of hypertensive patients according to the socio-economic status of Vietnam. Hypertension is defined as an office systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg which is equivalent to a 24-hr ambulatory blood pressure monitoring average of ≥130/80 mmHg or home blood pressure monitoring average of ≥135/85 mmHg. We established an integrated hypertensive diagnostic algorithm for adults with the optimal option by the role of out-of-office blood pressure measurement, especially home blood pressure monitoring, which is fully mended in this guideline. The threshold and target of hypertension treatment were individualized in safety range and effective evidence-based medicine. We also update for the management of resistant hypertension, hypertension in diabetic patients, hypertension with heart failure, and with orbidities. Vietnam has tried on the best strategy for improving the control of hypertension and recently received several achievements in the world, especially in the Asian region. Because the conditions for conducting our national data have not been fully conducted, we have to adapt from existing guidelines so there are still certain limitations that need to be supplemented and adjusted in the ing version.

36196471

Neurodegenerative diseases and blood pressure variability: A comprehensive review from HOPE Asia.

Asia has an enormous number of older people and is the primary contributor to the rise in neurodegenerative diseases such as Alzheimer's and Parkinson's disease. The therapy of many neurodegenerative diseases has not yet progressed to the point where it is possible to alter the course of the disease. Mid-life hypertension is an important predictor of later-life cognitive impairment and brain neurodegenerative conditions. These findings highlight the pivotal role of preventing and managing hypertension as a risk factor for neurodegenerative disease. Autonomic dysfunction, neuropsychiatric and sleep disturbances can arise in neurodegenerative diseases, resulting in blood pressure variability (BPV). The BPV itself can worsen the progression of the disease. In older people with neurodegenerative disease and hypertension, it is critical to consider 24-h blood pressure monitoring and personalized blood pressure therapy.

36196474

Central hypertension is a non-negligible cardiovascular risk factor.

High blood pressure (BP) confers cardiovascular risk. However, the clinical value of central BP remains debatable. In this article, we aim to briefly review the prognosis, diagnosis, and treatment of central hypertension. Central and brachial BPs are closely correlated. In most prospective investigations, elevated central and peripheral BPs were similarly associated with adverse es. e-driven thresholds of the central systolic BP estimated by the type I device were on average 10 mmHg lower than their brachial counterparts. Cross-classification based on the central and brachial BPs identified that nearly 10% of patients had discrepancy in their status of central and brachial hypertension. Irrespective of the brachial BP status, central hypertension was associated with increased cardiovascular risk, highlighting the importance of central BP assessment in the management of hypertensive patients. Newer antihypertensive agents, such as renin-angiotensin-aldosterone system inhibitors and calcium channel blockers, were more efficacious than older agents in central BP reduction. Clinical trials are warranted to demonstrate whether controlling central hypertension with an optimized antihypertensive drug treatment will be beneficial beyond the control of brachial hypertension.

36196475

Effectiveness of salt substitute on cardiovascular outcomes: A systematic review and meta-analysis.

Hypertension-related death is the leading cause of mortality worldwide, making blood pressure (BP) control an important issue. Salt substitute is a non-pharmaceutical strategy to improve hypertension control. The goal of this study was to evaluate the effect of salt substitute on BP and cardiovascular disease. The authors searched the Cochrane Library and PubMed databases through March 2022, and assessed the risk-of-bias for included studies by the Cochrane risk-of-bias tool. Twenty-three randomized controlled trials with 32073 patients were included in our systematic review. A meta-analysis with random effects was performed to analyze the effects of salt substitute on systolic and diastolic BP, 24-h urinary sodium and potassium, and cardiovascular and all-cause mortality. In the random-effects model, participants consuming salt substitute showed significant reduction in systolic BP (mean difference (MD) -4.80 mmHg, 95% confidence interval (CI) -6.12 to -3.48, P < 0.0001) and diastolic BP (MD -1.48 mmHg, 95% CI -2.06 to -0.90, pared with participants consuming normal salt. In the urine electrolyte analysis, the salt substitute group had significant reduction in 24-h urine sodium (MD -22.96 mmol/24-h, P = 0.0001) and significant elevation in 24-h urine potassium (MD 14.41 mmol/24-h, P < 0.0001). Of the five studies with mortality e data, salt substitute significantly reduced all-cause mortality (hazard ratio 0.88, P = 0.0003). In conclusion, our analyses showed that salt substitute has a strong effect on lowering BP and reducing all-cause mortality. By modifying the daily diet with salt substitute, the authors can improve BP control by using this non-pharmaceutical management.