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36196607 | Development of a Roadmap for the Antimicrobial Usage Monitoring System for Medical Institutions in Korea: a Delphi Study. | It is necessary to develop a roadmap for antimicrobial usage monitoring in order to perform monitoring of antimicrobial use at the national level properly. Therefore, this study aimed to develop a roadmap for establishing surveillance and monitoring of antimicrobial use in medical institutions at the national level. |
36196608 | Prediction of Adverse Outcomes among Women in the Third Trimester of Pregnancy with Coronavirus Disease 2019. | This study aimed pare the clinical and laboratory characteristics of two groups of women (favorable and adverse e groups) in the third trimester of pregnancy with coronavirus disease 2019 (COVID-19) and to investigate the predictors of specific adverse es. |
36196609 | Body Weight is Inversely Associated with Anti-SARS-CoV-2 Antibody Levels after BNT162b2 mRNA Vaccination in Young and Middle Aged Adults. | This study aimed to determine factors affecting serum levels of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies 2 months after coronavirus disease 2019 (COVID-19) vaccination in young and middle aged healthy adults. |
36196610 | Diagnostic Performance, Stability, and Usability of Self-Collected Combo Swabs and Saliva for Coronavirus Disease 2019 Diagnosis: A Case-Control Study. | Self-sampling procedures to detect severe acute respiratory syndrome coronavirus 2 is important for patients who have difficulty visiting the hospital and may decrease the burden for health care workers (HCWs). The objective of this study was to evaluate the diagnostic performance, stability and usability of self-collected nasal and bo swabs and saliva specimens. |
36196611 | The Incidence and Risk Factors of Renal Insufficiency among Korean HIV infected Patients: The Korea HIV/AIDS Cohort Study. | Renal insufficiency is one of mon issues in people living with human immunodeficiency virus (PLHIV). We studied the incidence and risk factors for renal insufficiency in male PLHIV using the Korea HIV/acquired immunodeficiency syndrome (AIDS) Cohort Study. Among the 830 enrolled patients, 32 (3.9%) cases of renal insufficiency occurred over 9576 patient-years of follow-up. The incidence of renal insufficiency in HIV-infected men in this study was 3.3 per 1000 patient-years. Diabetes mellitus, dyslipidemia, tenofovir or non-nucleoside reverse transcriptase inhibitor exposure for >1 year, and AIDS-defining illness were risk factors for renal insufficiency. |
36196612 | Preliminary Guidelines for the Clinical Evaluation and Management of Long COVID. | Long-lasting coronavirus disease 2019 (COVID-19) symptoms beyond 12 weeks, the so-called 'long COVID' have been increasingly reported worldwide. Long COVID can be manifested in various forms, and there is an increasing demand for proper assessment and management. However, it is challenging when trying to determine the best-practice standards of care based on the current evidence because there is no internationally agreed clinical definition or clear treatment pathway. Therefore, the present guidelines have been drafted to provide advice on diagnosis and management based on the latest updated available evidence and the consensus of expert opinion. So far, no standard test and drug treatment can be strongly mended for patients with long COVID because of a lack of evidence. The present guidelines provide advice based on 12 key questions, including appropriate interventions for long COVID that can be used in clinical practice. Continuous careful observation and studies related to long COVID are needed for the long-term impact of COVID-19 and proper management for long COVID to be determined. |
36196613 | Contemporary management of ventricular electrical storm in Europe: results of a European Heart Rhythm Association Survey. | Electrical storm (ES) is a predictor of mortality, and its treatment is challenging. Moreover, not all potential therapeutic strategies are available in all hospitals, and a standardized approach among European centres is lacking. The aim of this European Heart Rhythm Association (EHRA) survey was to assess the current management of patients with ES both in the acute and post-acute phases in 102 different European centres. A 20-item online questionnaire was sent out to the EHRA Research Network Centres. The median number of patients with ES treated annually per centre is 10 (IQR 5-15). The possibility of using autonomic modulation (e.g. percutaneous stellate ganglion block or thoracic epidural anaesthesia) for the acute ES treatment is available in only 29.3% of the centres. Moreover, although over 80% of centres perform ventricular tachycardia ablation, this procedure is available 24/7 in only 16.5% of the hospitals. There is a significant heterogeneity among centres regarding the availability of AADs and their use before deciding to proceed with a non-AAD strategy; specifically, 4.4% of centres use only one drug, 33.3% use two drugs, and 12.2% >two drugs, while about 50% of the centres decide based on individual patient's characteristics. Regarding the type of AADs used for the acute and post-acute management of ES patients, important variability is reported depending upon the underlying heart disease. Most patients considered for percutaneous ablation have structural heart disease. Only 46% of centres refer patients to psychological counselling after ES. |
36196615 | X-ray photoelectron spectroscopy of morpholinium ionic liquids: impact of a long alkyl side substituent on the cation-anion interactions. | In this study, X-ray photoelectron spectroscopy is used to analyse nine morpholinium ionic liquids, which are of great interest in green chemistry because of their low toxicity and high recyclability. The effect of the alkyl chain length on the aliphatic C 1s binding energy and the impact of the anion basicity on the cationic N 1s and O 1s binding energies are investigated. It is concluded that by changing the basicity of the anion, there is a more notable change in the electronic environment of the oxygen centre. The impact of a long alkyl side substituent on the cation-anion interactions is also discussed. It is observed that there is an intense charge shielding effect of the alkyl side chain in the cases of octyl and dodecyl substituents, which is reflected in the reduced Br 3d |
36196614 | Booster Vaccination Against SARS-CoV-2 Induces Potent Immune Responses in People With Human Immunodeficiency Virus. | People with human immunodeficiency virus (HIV) on antiretroviral therapy (ART) with good CD4 T-cell counts make effective immune responses following vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). There are few data on longer term responses and the impact of a booster dose. |
36196616 | A very-long-chain fatty acid synthesis gene, SD38, influences plant height by activating ethylene biosynthesis in rice. | As an important trait in crop breeding, plant height is associated with lodging resistance and yield. With the identification and cloning of several semi-dwarfing genes, increasing numbers of semi-dwarf cultivars have emerged, which has led to a 'green revolution' in rice (Oryza sativa) production. In this study, we identified a rice semi-dwarf mutant, semi-dwarf 38 (sd38), which showed significantly reduced cell length. SD38 encodes a fatty acid elongase, β-ketoacyl-CoA synthase, which is involved in the synthesis of very-long-chain fatty acids (VLCFAs). Expression analysis showed that SD38 was localized on the membrane of the endoplasmic reticulum, and was expressed in all analyzed tissues with differential abundance. The mutation of SD38 affected lipid metabolism in the sd38 mutant. A plementarity test in Saccharomyces cerevisiae indicated that SD38 was capable plementing the deficiency of ELO3p activity in BY4741-elo3 knockout yeast cells by participating in the synthesis of C24:0 VLCFA. Significant changes were observed in the expression of genes involved in ethylene synthesis, which resulted in reduced content of the ethylene precursor 1-aminocyclopropane-1-carboxylic acid (ACC) in the sd38 mutant. Exogenously supplied VLCFA (C24:0) increased the expression levels of OsACS3, OsACS4, and OsACO7 and the plant height of sd38 mutant seedlings, similar to the effect of exogenous application of ACC and ethephon. These results reveal a relationship among VLCFAs, ethylene biosynthesis, and plant height and improve our understanding of plant height development in crops. |
36196617 | Carbon dioxide capture with zeotype materials. | The accumulation of carbon dioxide (CO |
36196619 | Tools for manipulation and positioning of microtissues. | Complex three-dimensional (3D) |
36196618 | The GATA factor ELT-3 specifies endoderm in Caenorhabditis angaria in an ancestral gene network. | Endoderm specification in Caenorhabditis elegans occurs through a network in which maternally provided SKN-1/Nrf, with additional input from POP-1/TCF, activates the GATA factor cascade MED-1,2→END-1,3→ELT-2,7. Orthologues of the MED, END and ELT-7 factors are found only among nematodes closely related to C. elegans, raising the question of how gut is specified in their absence in more distant species in the genus. We find that the C. angaria, C. portoensis and C. monodelphis orthologues of the GATA factor gene elt-3 are expressed in the early E lineage, just before their elt-2 orthologues. In C. angaria, Can-pop-1(RNAi), Can-elt-3(RNAi) and a Can-elt-3 null mutation result in a penetrant 'gutless' phenotype. Can-pop-1 is necessary for Can-elt-3 activation, showing that it acts upstream. Forced early E lineage expression of Can-elt-3 in C. elegans can direct the expression of a Can-elt-2 transgene and rescue an elt-7 end-1 end-3; elt-2 quadruple mutant strain to viability. Our results demonstrate an ancestral mechanism for gut specification and differentiation in Caenorhabditis involving a simpler POP-1→ELT-3→ELT-2 gene network. |
36196622 | Coronal-plane leg alignment in adolescence and the effects of activity: A full leg length MRI study. | The aim of this study was to explore the association between developing coronal-plane leg alignment and activity levels during adolescence. We performed a cross-sectional cohort study with individuals from soccer club academies and an age-matched control population. e measures were the hip knee angle (HKA), medial proximal tibial physeal angle (MPTPhyA), lateral distal femoral physeal angle (LDFPhyA) on full leg length magnetic reasonance imagine scans, and the physical activity questionnaire (PAQ) score. The prised 57 elite male soccer players, 34 male and 34 female controls aged 11-21 years. Mean HKA became more varus with age, with little change after 16 years or skeletal maturity. Skeletally mature elite male soccer players were significantly more varus than male controls with a HKA 2.28° less than male controls (p < 0.001). Skeletally mature male controls had a HKA 1.34° less than female controls (p < 0.001). A negative correlation existed between HKA and PAQ score (coefficient -0.24, p = 0.029). A positive correlation existed between HKA and MPTPhyA (coefficient 0.32, p = 0.008). In conclusion, high activity levels during adolescence are associated with the development of varus leg alignment. Mean HKA es more varus with age until skeletal maturity. The development of varus alignment may represent a physiological adaptation to load at the proximal tibial physis. Clinical Significance: A time period may exist for intervention before the development of varus leg alignment in young athletes, such as training load modification or proximal tibial morphology monitoring. |
36196623 | A medium-weight deep convolutional neural network-based approach for onset epileptic seizures classification in EEG signals. | Epileptic condition can be detected in EEG data seconds before it occurs, according to evidence. To e the related long-term mortality and morbidity from epileptic seizures, it is critical to make an initial diagnosis, uncover underlying causes, and avoid applicable risk factors. Progress in diagnosing onset epileptic seizures can ensure that seizures and destroyed damages are detectable at the time of manifestation. Previous seizure detection models had problems with the presence of multiple features, the lack of an appropriate signal descriptor, and the time-consuming analysis, all of which led to uncertainty and different interpretations. Deep learning has recently made tremendous progress in categorizing and detecting epilepsy. |
36196621 | Machine learning classification reveals robust morphometric biomarker of glial and neuronal arbors. | Neurons and glia are the two main cell classes in the nervous systems of most animals. Although functionally distinct, neurons and glia are both characterized by multiple branching arbors stemming from the cell bodies. Glial processes are generally known to form smaller trees than neuronal dendrites. However, the full extent of morphological differences between neurons and glia in multiple species and brain regions has not yet been characterized, nor is it known whether these cells can be reliably distinguished based on geometric features alone. Here, we show that multiple supervised learning algorithms deployed on a large database of morphological reconstructions can systematically classify neuronal and glial arbors with nearly perfect accuracy and precision. Moreover, we report multiple morphometric properties, both size related and size independent, that differ substantially between these cell types. In particular, we newly identify an individual morphometric measurement, Average Branch Euclidean Length that can robustly separate neurons from glia across multiple animal models, a broad diversity of experimental conditions, and anatomical areas, with the notable exception of the cerebellum. We discuss the practical utility and physiological interpretation of this discovery. |
36196624 | Ionic Signal Amplification of DNA in a Nanopore. | Ionic signal amplification is a key challenge for single-molecule analyses by solid-state nanopore sensing. Here, a permittivity gradient approach for amplifying ionic blockade characteristics of DNA in a nanofluidic channel is reported. The transmembrane ionic current response is found to change substantially through modifying the liquid permittivity at one side of a pore with an organic solvent. Imposing positive liquid permittivity gradients with respect to the direction of DNA electrophoresis, this study observes the resistive ionic signals to e larger due to the varying contributions of molecular counterions. On the contrary, negative gradients render adverse effects causing conductive ionic current pulses upon polynucleotide translocations. Most importantly, both the positive and negative gradients are demonstrated to be capable of amplifying the ionic signals by an order of magnitude with a 1.3-fold difference in the transmembrane liquid dielectric constants. This phenomenon allows a novel way to enhance the single-molecule sensitivity of nanopore sensing that may be useful in analyzing secondary structures and genome sequence of DNA by ionic current measurements. |
36196625 | ISL1/SHH/CXCL12 signaling regulates myogenic cell migration during mouse tongue development. | Migration of myoblasts derived from the occipital somites is essential for tongue morphogenesis. However, the molecular mechanisms of myoblast migration remain elusive. In this study, we report that deletion of Isl1 in the mouse mandibular epithelium leads to aglossia due to myoblast migration defects. Isl1 regulates the expression pattern of chemokine ligand 12 (Cxcl12) in the first branchial arch through the Shh/Wnt5a cascade. Cxcl12+ mesenchymal cells in Isl1ShhCre embryos were unable to migrate to the distal region, but instead clustered in a relatively small proximal domain of the mandible. CXCL12 serves as a bidirectional cue for myoblasts expressing its receptor CXCR4 in a concentration-dependent manner, attracting Cxcr4+ myoblast invasion at low concentrations but repelling at high concentrations. The accumulation of Cxcl12+ mesenchymal cells resulted in high local concentrations of CXCL12, which prevented Cxcr4+ myoblast invasion. Furthermore, transgenic activation of Ihh alleviated defects in tongue development and rescued myoblast migration, confirming the functional involvement of Hedgehog signaling in tongue development. In summary, this study provides the first line of genetic evidence that the ISL1/SHH/CXCL12 axis regulates myoblast migration during tongue development. |
36196626 | Recent advances in the treatment of childhood asthma: a clinical pharmacology perspective. | Childhood asthma is plex heterogenous inflammatory disease that can pose a large burden on patients and their caregivers. There is a strong need to adapt asthma treatment to the individual patient taking into account underlying inflammatory profiles, moving from a 'one size fits all' approach toward a much-needed personalized approach. |
36196627 | Flexible Omnidirectional Self-Powered Photodetectors Enabled by Solution-Processed Two-Dimensional Layered PbI | Realizing omnidirectional self-powered photodetectors is central to advancing next-generation portable and smart photodetector systems. However, the traditional omnidirectional photodetector is typically achieved by plex hemispherical microlens on multiple photodetectors, which makes the detection system cumbersome and restricts its application in the portable field. Here, facile and high-performance flexible omnidirectional self-powered photodetectors are achieved by solution-processed two-dimensional (2D) layered PbI |
36196628 | Impact of Metabolic Syndrome on Left Ventricular Deformation and Myocardial Energetic Efficiency Compared Between Women and Men: An MRI Study. | Metabolic and hemodynamic alterations in metabolic syndrome (MetS) can cause a reduced myocardial energetic efficiency (MEE). Indexed MEE (MEEi), as a simple estimate of MEE, is emerging as a novel and useful imaging parameter. |
36196629 | [Ethical Duties in Disaster Preparedness.] | The experience of the COVID-19 pandemic and the horizon of expectations in relation to climate change reminds us that it is a collective responsibility to anticipate to the best of our ability and knowledge the risks of foreseeable disasters and their potential impacts on munities. The article will examine the meaning and status of moral duties regarding disaster preparedness by adopting a disaster ethics approach which draws on the interrelationship of bioethics with public health ethics and looks at the full cycle of disaster management and the corresponding cycle of protection of victims and professionals. After discussing some normative controversies panying well-known classifications of disasters and characterizing the ethical turn to preparedness in disaster management, it will be argued that preparedness duties include obligations relating to planning, anticipation, and prevention of disasters and that they are derivative and positive duties involving a series of prospective, shared and institutionally mediated responsibilities. |
36196630 | Engrailed homeobox 1 transcriptional regulation of COL22A1 inhibits nasopharyngeal carcinoma cell senescence through the G1/S phase arrest. | EN1 is well known as a transcription factor in other tumours, but its role in NPC is unclear. In this study, we first used bioinformatics to analyse GEO data to obtain the differentially expressed gene EN1, and subsequently verified that EN1 was highly expressed in nasopharyngeal carcinoma cells by tissue microarrays as well as cell lines. Further, we down-regulated the expression of EN1 in cells for RNA sequencing. The analysis of sequencing results using KEGG and GO revealed significant changes in cell proliferation and cycle function after downregulation of EN1. Meanwhile, we found that cells underwent senescence after inhibition of EN1 under electron microscopy and the SA-β-gal assays. Based on the sequencing results, we verified that EN1 can promote the proliferation and cycle of NPC cells in cell function experiments and animal experiments. To investigate how EN1 affects cell senescence, we found that EN1 transcriptional regulation of COL22A1 regulated cell proliferation and cycle via CDK4/6-cyclin D1-Rb signalling pathway by dual luciferase reporter, Immunoblotting and rescue experiment. Accordingly, we uncovered that EN1 could serve as a target for the regulation of senescence in NPC. |
36196631 | [The role of solidarity in a pandemic.] | Solidarity is part of the map of values and ethical principles of the COVID-19 pandemic that has devastated the world since the end of 2019. Solidarity has been behind the justification for public health measures such as confinement, quarantines, lockdowns, the mandatory use of masks, and the financing, distribution and inoculation of vaccines against the virus; it has also been used to pensation, intergenerational sacrifices, the importance of public health care and even mutual aid between citizens, institutions and countries to face the worst effects of the pandemic. However, solidarity has been used interchangeably as a descriptive and normative, motivational and justificatory, sentimental and political, moral and legal idea, thus increasing confusion about its meaning, use and scope. This article reviews the rhetorical use of solidarity during the pandemic, shows the contradictions derived from that use, and sheds light on the normative use it should have in order to more rigorously address responses to future pandemics. |
36196632 | [COVID-19, black swans and the anticipation of health disasters: future problems and the future as a problem in Public Health ethics.] | The COVID-19 pandemic has recalled the importance of prevention and preparedness for highly disastrous events munity health. Several emerging phenomena pose prospective threats to public health. However, the largely future-oriented character of problems, for instance, such as antibiotic resistance, the impact of climate change on health, or the bioengineering of pathogens generates difficulties of analysis. What are the ethical and epistemological challenges raised by future public health problems? How should the moral problems of potentially catastrophic future scenarios be addressed? This article argues in favour of adopting anticipatory ethical approaches from public health ethics. First, it will be argued that addressing these future problems requires reflection on the future as an ethical and epistemic problem. Second, the characteristics of the emerging anticipatory ethics in the fields of ethics of technology and bioethics will be clarified. Third, the application of foresight and anticipatory methodologies in public health ethics debates will be defended. Finally, some reflections will be offered to strengthen anticipatory normative analyses to prevent and address in advance the adverse effects of future health crises. |
36196633 | [Prevention: with citizen participation.] | Learning from the SARS-CoV-2 consequences is essential in order to anticipate future pandemics. Moreover, it is pelling reason to make substantive improvements in both public health and prevention systems. However, preparedness seems a difficult task when people show pandemic fatigue or question decisions that would affect their personal sphere. To deal with such reactions, it seems important to leave open some avenues for citizens' involvement, a strategy mended by the World Health Organization and the European Commission. Here the main argument is in favor of a civic approach of prevention: 1) Preparedness to anticipate future pandemics is a duty; 2) But, so far, it is not a priority issue for the political agenda; 3) Neither is citizens' collaboration in the governance of health policy. Therefore, we could ask about the channels munication and participation that are available to citizens, entities or stakeholders, to discuss public health issues. |
36196634 | [Motivational deficits in the promotion of public health? A matter for reflection on religion and COVID-19.] | The paper is aimed to analyze if religion plays a relevant role in health promotion and, thus, if it can be included in the interpretations on the positive role of religions in the public sphere. In this regard, Habermas refers to a crisis of meaning in secular societies that has been caused, among other reasons, by individualistic and selfish lifestyles that fail to encourage a moral action when it goes beyond the law. In contrast, it seems that the strong social ties of munities foster solidarity and altruistic attitudes, which could be interpreted as a sign of greater social cohesion; but is it really like that? Pandemic and its consequences help to assess whether the religious element (analyzed as belief, belonging, bonding and behavior) has created positive attitudes in the face of the health challenges pliance with rules of social distance, vaccination) or, on the contrary, the motivational deficits of some societies have to do with other factors not related to the religious/secular dichotomy. |
36196635 | [History repeats itself: an ethic for two pandemics.] | The emergence of the human immunodeficiency virus (HIV) in the 1980s brought ethical conflicts that meant a bioethics challenge. Among others, issues of confidentiality, stigmatization, justice, duty of care and investigation arose. Bioethical reflection had been focused on conflicts involving respect for individual autonomy, nevertheless HIV highlighted the needs of munity. Almost four decades later, the COVID-19 pandemic has brought the ethical conflicts typical of public health back to the bioethical scene. Quarantines, various restrictions on mobility, the obligation of masks, poorly protected health care, rationing of scarce resources, rushed research, the vaccines allocation, stigmatization and discrimination, the immune passport, or the moralization of infectious disease have highlighted the need for an ethical framework that helps to reflect and justify public health decisions. In this article we review and analyze the ethical conflicts that arose with HIV and how they have reappeared and been reinterpreted with the COVID-19 pandemic. |
36196636 | [The ethics of health nudges: a discussion about their acceptability in public health.] | In behavioral science, the term nudge refers to any aspect of decision architecture that predictably alters people's behavior to improve the chooser's own welfare without forbidding or significantly restricting their choices. Its promoters invoke libertarian paternalism, which means, on the one hand, that the behavior of the individual is guided without counting on his autonomy, but, on the other hand, that this form of influence does not reach the point of restricting freedom of choice when it is manifest. This paper analyzes the role of nudges in the field of health policies. A cognitive analysis of these nudges is carried out and are distinguished the clinical nudges (those that take place within the healthcare professional and patient relationship) from the public health nudges (specific to public health policies). The ethical aspects of both categories of nudge will be analyzed to point out some of their virtues and the ethical challenges they face. This study focuses in particular on public health nudges, to consider whether it is reasonable, and with what limits, their implementation in health crises (for example, pandemics). Analyzing that public policies face the dilemma between preserving freedom at the expense of health or, on the contrary, prioritize health to the point of limiting freedom. It is raised whether in this context greater restrictions on individual freedoms should be allowed (for example, through mandatory lockdowns and quarantines, imposed vaccinations, forced tests) or whether to use nudges as an intermediate solution and less harmful to individual rights to promote health measures. |
36196638 | [Pandemia, ignorancia y sufrimiento evitable.] | COVID-19 pandemics gave us relevant lessons that are going to leave a durable mark in our individual and collective experience. Those lessons are both practical and endowed with a moral import. But the pandemic has left a trail of experiences poorly elaborated that leads, with some urgency, to forced silence and to the cancellation of emotional trauma. The aim of this paper was to disentangle plex relationship that arises, under conditions of uncertainty, between knowledge and ignorance, both from the perspective of experts and of policy makers, and even of the ordinary people, struck or not by the SARS-CoV-2 virus. To that end, I distinguish between three different levels of analysis (agency, institutions, and ideological frameworks) so to argue that the mismatches that occur in all of them, and between them, are sources of avoidable harm. The purpose of this exploration was, therefore, to bring to the floor, relying on the conceptual tools of the political epistemology, both the aspects of the traumatic experience that still lack an adequate elaboration and the features that provide an improved resilience for individuals and societies in tackling with the frightful consequences of the pandemic. |
36196639 | Absence of atrial smooth muscle in the heart of the loggerhead sea turtle (Caretta caretta): a re-evaluation of its role in diving physiology. | Contraction of atrial smooth muscle in the hearts of semi-aquatic emydid turtles regulates ventricular filling, and it has been proposed that it could regulate stroke volume during characteristic rapid transitions in cardiac output associated with diving. For this hypothesis to be supported, atrial smooth muscle should be widely distributed in diving Testudines. To further understand the putative function and evolutionary significance of endocardial smooth muscle in Testudines, we studied the hearts of loggerhead sea turtles, Caretta caretta (n=7), using immunohistochemistry and histology. Surprisingly, we found no evidence of prominent atrial smooth muscle in C. caretta. However, smooth muscle was readily identified in the sinus venosus. Our results suggest that atrial smooth muscle does not contribute to the diving capabilities of C. caretta, indicating that the possible roles of smooth muscle in emydid turtle hearts require a re-evaluation. In sea turtles, the sinus venosus may instead contribute to regulate cardiac filling. |
36196640 | DUX4 expression activates JNK and p38 MAP kinases in myoblasts. | Facioscapulohumeral muscular dystrophy (FSHD) is caused by misexpression of the DUX4 transcription factor in skeletal muscle that results in transcriptional alterations, abnormal phenotypes and cell death. To gain insight into the kinetics of DUX4-induced stresses, we activated DUX4 expression in myoblasts and performed longitudinal RNA sequencing paired with proteomics and phosphoproteomics. This analysis revealed changes in cellular physiology upon DUX4 activation, including DNA damage and altered mRNA splicing. Phosphoproteomic analysis uncovered rapid widespread changes in protein phosphorylation following DUX4 induction, indicating that alterations in kinase signaling might play a role in DUX4-mediated stress and cell death. Indeed, we demonstrate that two stress-responsive MAP kinase pathways, JNK and p38, are activated in response to DUX4 expression. Inhibition of each of these pathways ameliorated DUX4-mediated cell death in myoblasts. These findings uncover that the JNK pathway is involved in DUX4-mediated cell death and provide additional insights into the role of the p38 pathway, a clinical target for the treatment of FSHD. |
36196641 | [Milk donation and pandemic: human milk as a global good.] | The human milk donation has been an undervalued and very biasedly examined subject until relatively recently, parison with other types of human donation (organs, tissues, fluids), not being recognized its dimension of bodily altruistic and philanthropic act in the same way as other (mildly) analogous realities, as well as in its approach from the perspective of feminist and gender studies. On the other hand, although the COVID-19 pandemic and the various lockdown processes have had an onerous impact on human breastfeeding in general, we find data on the global increase in breastfeeding donation as a specific altruistic gesture during the pandemic in Spain and, even, on the decisions in the plicated moments of the state of alarm about donating one's own milk in the tragedy of perinatal death. These altruistic donations contribute to carrying out the fulfillment of what has already been declared a human right and one of the social investments with the most advantageous cost-benefit index. The recognized, intensified and amplified need for milk banks in a pandemic brings to the fore in a specific way the condition of human milk as capital physiological resource, and, ultimately, as a global good. This article is dedicated to delving into a critical hermeneutics of milk donation in light of the pandemic and as an opportunity to rethink the studies of recent decades in this regard. |
36196642 | [Scope and limits of the technologization of care: lessons from a pandemic.] | During the COVID-19 pandemic, technology has been used to carry out numerous activities. These uses have often been poorly planned, as the urgency of the situation did not allow for careful considerations. Technology has helped us to maintain many aspects of life that the pandemic had done difficult; however, it has also brought some new problems, especially when es to situations of vulnerability and care settings. In this article we analyse the nature and use of technology in assistive and care settings during the pandemic, its basis, its scope, and its limitations. To do so, we study the specific case of the use of digital video-calling platforms during the forced isolations caused by the pandemic. |
36196643 | [Health from ecological justice: from the regeneration of wild nature to the prevention of future pandemics.] | The aim of this article is to explore a philosophical perspective on health linked to the restoration of wild nature, especially on the basis of some lessons that can be drawn from the spread of recent zoonotic diseases. The first section presents the relationship that the COVID-19 pandemic has maintained with social justice, venturing the thesis that ecological justice is a dimension that should be incorporated with deeper attention. To justify this, the following sections propose, first at the conceptual level, to approach a concept of health that is plural, dynamic and interdependent, and, then at the pragmatic level, to take as a reference the casuistry that shows an inverse correlation between the presence of wild biodiversity in a territory and contagion by zoonoses. In sum, these thoughts may lead to justify anticipatory duties for future pandemics and a responsibility for global health that deserve to be analyzed from an ethical point of view. |
36196644 | Connect Four: Tetraarylated Dihydropentalenes and Triarylated Monocyclic Pentafulvenes from Cyclopentadienes and Enones. | In search of novel pentalenide ligands for use in organometallic chemistry and homogeneous catalysis, we report the scope of a straightforward base-promoted Michael annulation of cyclopentadienes with α,β-unsaturated ketones that allows the introduction of symmetrical as well as unsymmetrical aryl and alkyl substitution patterns including electron-donating as well as electron-withdrawing substituents. More than 16 examples of various isomers of 1,3,4,6-tetraarylated dihydropentalenes have been synthesized in isolated yields of up to 78%, representing a substantial expansion of the range of dihydropentalene scaffolds known to date. Double bond isomerization between the two pentacyclic rings in 1,2-dihydropentalenes with electronically different substituents occurred depending on the polarization of the molecule. The melting points of the air-stable dihydropentalenes decrease, and their solubilities in organic solvents improve with increasing substitution and decreasing symmetry of the molecule. petitive pseudo-retro-aldol pathway produces 1,3,6-triarylated monocyclic pentafulvenes as side products in yields of 9-68%, which can be cleanly isolated (8 new examples) and used for other synthetic purposes, including separate cyclization to other dihydropentalenes. |
36196645 | [The carelessness and the inhospitable. Inhabiting times of pandemic.] | The pandemic has placed us in a situation of estrangement from ourselves. We have been acutely aware of our vulnerability and fragility. Through the stories of lived experiences, we have learned about and witnessed tragic circumstances in which inhospitality and neglect have e evident. We have been shocked by the awareness of the lack of recognition, paniment and e. Institutional decisions have prioritized public health, the good for all, but have forgotten the biographies of people, full of suffering. And this has produced a moral damage, a loss of trust, a feeling of injustice that we have not been able to fight against. This is why it is necessary to build hospitality, which can be achieved through care. Care with a political dimension that takes charge of reality and transforms society. The key is a responsibility in solidarity. Faced with the possibility of dehumanizing ourselves, we seek hospitality as an alternative way of narrating lives that have to be reconstructed, that have to relearn how to take care of each other amidst the multiple possibilities of estrangement that threaten us. Hospitality is at the heart of a narrative ethics at the height of our times. |
36196646 | Can virtual-reality simulation ensure transthoracic echocardiography skills before trainees examine patients? | This study aimed to develop and gather the validity evidence for a standardised simulation-based skills test in transthoracic echocardiography and to establish a credible pass/fail score. |
36196647 | Diabetes Mellitus is Associated With Higher Serum Neurofilament Light Chain Levels in the General US Population. | Serum neurofilament light chain (sNfL) levels are biomarkers of neuroaxonal injury in multiple neurological diseases. |
36196648 | Intestinal Calcium Absorption Decreases After Laparoscopic Sleeve Gastrectomy Despite Optimization of Vitamin D Status. | Laparoscopic sleeve gastrectomy (LSG), now the monly performed bariatric operation, is a highly effective treatment for obesity. While Roux-en-Y gastric bypass is known to impair intestinal fractional calcium absorption (FCA) and negatively affect bone metabolism, LSG's effects on calcium homeostasis and bone health have not been well characterized. |
36196650 | Ultrasound-guided versus conventional peribulbar anaesthesia in cataract surgery: A randomised controlled study. | Blind ophthalmic anaesthetic techniques may have plications. |
36196649 | Withdrawal: A key consideration in evaluating whether highly processed foods are addictive. | Researchers are currently debating whether theories of addiction pulsive overeating of highly processed (HP) foods (i.e., industrially created foods high in refined carbohydrates and/or fat), which contributes to obesity and diet-related disease. A subset of individuals consumes HP foods with behavioral phenotypes that mirror substance use disorders. Withdrawal, the emergence of aversive physical and psychological symptoms upon reduction or cessation of substance use, is a ponent of addiction that was central to historical debates about other substances' addictive potential (e.g., nicotine and cocaine). However, no one has systematically considered evidence for whether HP foods cause withdrawal, which represents a key knowledge gap regarding the utility of addiction models for pulsive overeating. Thus, we reviewed evidence for whether animals and humans exhibit withdrawal when reducing or eliminating HP food intake. Controlled experimental evidence indicates animals experience HP food withdrawal marked by neural reward changes and behaviors consistent with withdrawal from other addictive substances. In humans, preliminary evidence supports subjective withdrawal-like experiences. However, most current human research is limited to retrospective recall. Further experimental research is needed to evaluate this construct. We outline future research directions to investigate HP food withdrawal in humans and consider potential clinical implications. |
36196651 | [Feminist public health, another view on the pandemic.] | Theorists of the ethics and politics of care, with their feminist and intersectional analyses, have spent decades trying to leave their mark on clinical practice and political structures . In them, extensive processes of humanization of the relationship between professionals and people who need their care are required, without neglecting inequalities due to gender, social class or belonging to vulnerable minority groups that go through health and disease experiences in munity. society. It is evident that our institutions must be extensively rethought in their foundations; from nursing homes to highly technological ICUs; from the saturation of primary care to the lack of specialized personnel. In areas such as nursing, great emphasis is placed on models based on interdependence and the particular context to generate another care framework , while fighting for hierarchies and invisibilities related to highly feminized professions . Not surprisingly, the reflections that follow are signed by three women with hybrid profiles who have dedicated part of our working life to the field of primary and hospital care (both in nursing and in physiotherapy) and, in turn, to research and teaching in bioethics, philosophy and humanities. We have experienced in our flesh the contradictions between a will to serve and some axes of oppression connatural to the institutions. |
36196653 | Modified Stranski-Krastanov Growth of Amino Acid Arrays toward Piezoelectric Energy Harvesting. | Biomolecule-based piezoelectric nanostructures emerged as a new class of energy-converse materials, and designing tailored piezoelectric amino acid arrays is essential to achieve efficient electrical-mechanical coupling and fulfill their application potential. However, the controlled growth of amino acid nanostructures is still challenging due to the limited understanding of their growth mechanism. Herein, we base on the Stranski-Krastanov (S-K) growth mode and propose a mechanism for the growth of ordered amino acid array structures via physical vapor deposition. The growth of vertical valine sheet arrays is examined by changing the substrate temperature, chamber pressure, and source-substrate distance, and a "layer-plus-sheet" growth process is revealed. The modified S-K growth mode is applied to fabricate other amino acid nanostructures like leucine and isoleucine. The growth mode not only explains the formation of uniform and controllable morphology of amino acid structures but also leads to the significant enhancement of their piezoelectric properties. The maximal effective piezoelectric constant of valine sheets is 11.4 pm V |
36196652 | Floppy iris syndrome associated with specific medication intake: A narrative review. | Intraoperative floppy iris syndrome (IFIS) is a cataract plication that remains a challenge for eye surgeons. It is caused by the antagonism of alfa-1-adrenergic receptors within the dilator muscle of the iris, thus preventing the iris from dilation during a cataract surgery. The long-term blocking alfa-1 adrenergic receptors by the chronic use of a number of systemic medications may lead to permanent anatomical atrophy of the dilator muscle of the iris. The mon drugs associated with the development of IFIS are tamsulosin and other alpha-1 adrenergic receptor antagonists prescribed to patients with low urinary tract symptoms (LUTS). There are other systemic medications that have been reported to have increased risk for IFIS. It is crucial for the ophthalmologist to identify the high-risk patients prone to develop IFIS. Its presence plicate the course of cataract surgery, ultimately negatively affecting visual e. Cataract surgery should be performed by an experienced eye surgeon using alternative pharmacological and surgical techniques. Interdisciplinary cooperation is essential to mitigate plications. Patients should be informed by their physicians about the need to report a medication history to their eye specialists, especially before cataract surgery. |
36196654 | How the public evaluates media representations of uncertain science: An integrated explanatory framework. | Understanding how to portray uncertain science to the public is a pressing goal for munication. This pared US public audience reactions to a news article depicting a novel discovery in neurogenomics as certain or uncertain, with statements of (un)certainty attributed to either affiliated or unaffiliated scientists. The uncertainty disclosure had no main effect on perceived news article credibility, scientist trustworthiness, objectivity of the scientists' depiction, or willingness to participate in genomic research. However, news credibility and scientist objectivity ratings were higher for uncertainty disclosure attributed to the affiliated scientists. Participants with greater preference for information about uncertainty found the scientists more trustworthy, their depictions more balanced, and the news article more credible when the research was described as uncertain, and these effects were stronger for affiliated scientist attribution. Findings underscore the important roles of disclosure source and audience characteristics in public reactions to media representations of scientific uncertainty. |
36196655 | Application of time domain nuclear magnetic resonance (TD-NMR) for study of the distillation curve of petroleum. | Crude oil distillates are a highly useful industrial product, mainly for energy generation. Unfortunately, they are rarely studied, mainly due to the low accessibility to products directly obtained from the distillation process, which is a laborious, expensive, and time-consuming operation. This work presents and discusses the use of time-domain nuclear magnetic resonance (TD-NMR) as a simple, affordable, and straightforward tool for the development of correlations supported on the transverse relaxation time (T |
36196656 | PlantRNA 2.0: an updated database dedicated to tRNAs of photosynthetic eukaryotes. | PlantRNA ( is prehensive database of transfer RNA (tRNA) gene sequences retrieved from fully annotated nuclear, plastidial and mitochondrial genomes of photosynthetic organisms. In the first release (PlantRNA 1.0), tRNA genes from 11 organisms were annotated. In this second version, the annotation was implemented to 51 photosynthetic species covering the whole phylogenetic tree of photosynthetic organisms, from the most basal group of Archeplastida, the glaucophyte Cyanophora paradoxa, to various land plants. tRNA genes from lower photosynthetic organisms such as streptophyte algae or lycophytes as well as extremophile photosynthetic species such as Eutrema parvulum were incorporated in the database. As a whole, about 37 000 tRNA genes were accurately annotated. In the frame of the tRNA genes annotation from the genome of the Rhodophyte Chondrus crispus, non-canonical splicing sites in the D- or T-regions of tRNA molecules were identified and experimentally validated. As for PlantRNA prehensive biological information including 5'- and 3'-flanking sequences, A and B box sequences, region of transcription initiation and poly(T) transcription termination stretches, tRNA intron sequences and tRNA mitochondrial import are included. |
36196662 | Predictive models for social functioning in healthy young adults: A machine learning study integrating neuroanatomical, cognitive, and behavioral data. | Poor social functioning is an emerging public health problem associated with physical and mental health consequences. Developing prognostic tools is critical to identify individuals at risk for poor social functioning and guide interventions. We aimed to inform prediction models of social functioning by evaluating models relying on bio-behavioral data using machine learning. With data from the Human Connectome Project Healthy Young Adult sample (age 22-35, N = 1,101), we built Support Vector Regression models to estimate social functioning from variable sets of brain morphology to behavior with plexity: 1) brain-only model, 2) brain-cognition model, 3) cognition-behavioral model, and bined brain-cognition-behavioral model. Predictive accuracy of each model was assessed and the importance of individual variables for model performance was determined. bined and cognition-behavioral models significantly predicted social functioning, whereas the brain-only and brain-cognition models did not. Negative affect, psychological wellbeing, extraversion, withdrawal, and cortical thickness of the rostral middle-frontal and superior-temporal regions were the most important predictors in bined model. Results demonstrate that social functioning can be accurately predicted using machine learning methods. Behavioral markers may be more significant predictors of social functioning than brain measures for healthy young adults and may represent important leverage points for preventative intervention. |
36196663 | Responding to warming in polar oceans: A commentary on Molina et al. (2022). | Antarctic marine species live in one of the most thermally stable environments on Earth. They have evolved in these cold stable conditions for many millions of years. The long period for evolution, the isolation and mixing of populations produced by glacial cycles and the environmental heterogeneity in terms of light, productivity and physical disturbance, has produced a diverse fauna with an estimated 20 000 species, or more, living on the seabed. It has also produced a fauna that is possibly the most sensitive to warming on Earth in an environment that is changing faster than most, if not all, others. There is a great need to understand this threatened biodiversity and to find ways to mitigate the future prospects of species loss in this special environment that supports unique biology including the only vertebrate species on Earth that live without haemoglobin. |
36196664 | The diffusion mechanism of water in conductive metal-organic frameworks. | Water is one of the most important guest molecules in metal-organic frameworks (MOFs) since it often serves as a solvent for ions and other molecules. Studying the diffusion mechanism of water molecules in conductive MOFs (c-MOFs) is fundamental to harnessing the potential of c-MOFs in designing next generation energy storage devices. In this work, using molecular dynamics simulations, we show that water follows the Fickian-type of diffusion mechanism in different types of c-MOFs. We investigate the effect of the stacking and metal center type on the water diffusion coefficient in c-MOFs. Water in c-MOFs with eclipsed stacking is shown to have 21.5% higher diffusion coefficient than in c-MOFs with slipped-parallel stacking, and 4-8% higher diffusion coefficient than in bulk water. The physical reasons behind the reduced water diffusion coefficient in slipped-parallel stacking c-MOFs are the higher number of hydrogen bonds near the inner surface and the zig-zag geometry. This work provides a molecular insight into the water dynamics and water structure inside multiple types of c-MOFs. |
36196665 | Optogenetic Protein Cleavage in Zebrafish Embryos. | A wide array of optogenetic tools are available that allow for precise spatiotemporal control over cellular processes. These tools are particularly important to zebrafish researchers who take advantage of the embryo's transparency. However, photocleavable optogenetic proteins have not been utilized in zebrafish. We demonstrate successful optical control of protein cleavage in embryos using PhoCl, a photocleavable fluorescent protein. This optogenetic tool offers temporal and spatial control over protein cleavage events, which we demonstrate in light-triggered protein translocation and light-triggered apoptosis. |
36196666 | Examining the relationship between cognitive inflexibility and internalizing and externalizing symptoms in autistic children and adolescents: A systematic review and meta-analysis. | Compared to neurotypical peers, autistic adolescents show greater cognitive inflexibility (CI) which manifests at the behavioral and cognitive level and potentially increases vulnerability for the development of internalizing (INT) and externalizing (EXT) symptoms. This systematic review and meta-analysis explored the association between CI and INT/EXT in autistic adolescents. PubMed, EMBASE, MEDLINE, PsycINFO and Web of Science databases were searched to identify relevant studies until April 2022 (PROSPERO protocol: CRD42021277294). Systematic review included 21 studies (n = 1608) of CI and INT, and 15 studies (n = 1115) of CI and EXT. A pooled effect size using Pearson's correlation between CI and INT/EXT was calculated and the moderating effects of age, sex, IQ and study quality were investigated using meta-regressions. Sensitivity analyses pleted to investigate the impact of measure variance for CI and co-occurring ADHD on the overall effects. Greater CI is associated with increased INT (nine studies; n = 833; r = 0.39 (moderate effect), 95% confidence interval [0.32, 0.46]) and EXT (six studies; n = 295; r = 0.48 (large effect), 95% confidence interval [0.38, 0.58]). Results withheld when only using parental reports of CI and excluding autistic adolescents with co-occurring ADHD. Increased CI may be a transdiagnostic vulnerability factor that can increase autistic adolescents' rigid or perseverative patterns of unhelpful cognition and behaviors and reduce their ability to access psychological interventions. Addressing CI may improve autistic children and adolescents' engagement with psychological therapy for co-occurring mental health difficulties. |
36196667 | Epidemiology of Rickettsia spp. in Atlantic rainforest areas of island and seashore mainland, southern Brazil. | Non-fatal cases of rickettsial infection with different clinical features than the classic BSF (Brazilian Spotted Fever) have been reported in seashore areas of Paraná state, southern Brazil. In addition, Amblyomma ovale tick infected by Rickettsia parkeri strain Atlantic rainforest has been also described in this area. Accordingly, the aim of this study was to investigate the occurrence of anti-Rickettsia spp. antibodies in human and dog populations, and Rickettsia spp. infection in ticks from oceanic islands and seashore mainland cities of southern Brazil. Serum samples were collected from 328 persons and their 282 dogs from three islands and two seashore mainland cities. A total of 211 ticks were collected from dogs, identified as A. ovale and R. sanguineus. In overall, 40 of 328 (12.2%) human samples were seropositive for Rickettsia spp., including 21 of 190 (11.1%) on islands and 19 of 138 (13.7%) on seashore mainland, and 62 of 282 (22.0%) dog samples, including 31 of 153 (20.3%) on islands and 31 of 129 (24.0%) in seashore mainland areas. In overall, nine of 82 (11.0%) ticks were positive to real-time PCR assay targeting a fragment of the rickettsial gltA gene, including two of 64 (3.1%) Rickettsia sanguineus and seven of 18 (38.9%) A. ovale, of which four were infected with the R. parkeri strain Atlantic rainforest. Despite no association between risk factors and Rickettsia spp. seropositivity was found in human beings, access to natural areas (p = .011) and tick infestation (p = .004) was significantly associated to dog seropositivity. The serological and molecular findings herein have confirmed previous tick and clinical case reports and enlarged the geographical occurrence of A. ovale infected by R. parkeri strain Atlantic rainforest in oceanic islands and seashore mainland cities of Paraná State, indicating a new likely transmission area of this new rickettsial infection in human beings and dogs of southern Brazil. |
36196668 | An advanced primary explosive and secondary explosive based on a zwitterionic pyrazole-triazole derivative. | Two zwitterionic energetic materials containing a pyrazole-triazole backbone were synthesized and fully characterized. Compound 3 can serve as an ideal secondary explosive due to its high position temperature (>200 °C), low impact sensitivity (>40 J), and excellent calculated detonation velocity (9090 m s |
36196669 | Effects of transgenic cotton lines expressing dsAgCYP6CY3-P1 on the growth and detoxification ability of Aphis gossypii glover. | The pest Aphis gossypii Glover globally causes considerable economic losses on various crops by its feeding damage and disease transmission. Transgenic plants that produce double-stranded RNA (dsRNA) targeted to insect genes are being developed as a pest control strategy. In this study, we evaluated the effects of transgenic cotton-mediated RNA interference (RNAi) on the growth and detoxification ability of A. gossypii after the transgenic cotton lines expressing dsAgCYP6CY3-P1 (the TG cotton lines) were obtained on the basis of exploring the functions of CYP6CY3 in our previous research. |
36196671 | Correction: Visualization of intercellular cargo transfer using upconverting nanoparticles. | Correction for 'Visualization of intercellular cargo transfer using upconverting nanoparticles' by Yeongchang Goh |
36196672 | Seasonal turnover and insights into the overwintering biology of wireworms (Coleoptera: Elateridae) in the Canadian Prairies. | The long-lived terricolous larvae of click beetles, colloquially called wireworms, pose a significant threat to agriculture worldwide. Several economically important pest species have been documented in the Canadian Prairies, including Hypnoidus bicolor, Limonius californicus and Hypnoidus abbreviatus. However, most monitoring activities are performed in the early spring and there is evidence from other geographical regions of seasonal shifts in wireworm position and prevalence. Further, little is known about the overwintering physiology or behaviors of wireworms, which undoubtedly contribute to their population dynamics. |
36196670 | Iatrogenic ureteric injury during abdominal or pelvic surgery: a meta-analysis. | To assess the incidence of ureteric injuries, clinical value of prophylactic ureteric stenting and impact of intra- or postoperative detection of ureteric injuries in patients treated with gynaecological or colorectal surgery. |
36196673 | Psychological resilience in older adults with type 2 diabetes from the Look AHEAD Trial. | There is growing interest in identifying factors associated with healthy aging. This cross-sectional study evaluated associations of psychological resilience with factors associated with aging in older adults with type 2 diabetes mellitus (T2DM). |
36196674 | Evolution of testicular asymmetry during puberty in adolescents without and with a left varicocele. | To assess the evolution of the Testicular Atrophy Index (TAI) in adolescent boys with and without a left varicocele with special attention for the currently postulated cut-off value of 20%. |
36196676 | Carbon doping endows silicon oxide with enhanced redox kinetics of polysulfides. | Carbon-doped SiO |
36196677 | Oxidation and de-alloying of PtMn particle models: a computational investigation. | We present putational study of the energetics and mechanisms of oxidation of Pt-Mn systems. We use slab models and simulate the oxidation process over the most stable (111) facet at a given Pt |
36196678 | Application and mechanisms of metal-based nanoparticles in the control of bacterial and fungal crop diseases. | Nanotechnology is a young branch of the discipline generated by nanomaterials. Its development has greatly contributed to technological progress and product innovation in the field of agriculture. The antimicrobial properties of nanoparticles (NPs) can be used to develop nanopesticides for plant protection. Plant diseases caused by bacterial and fungal infestations are the main types of crop diseases. Once infected, they will seriously threaten crop growth, reduce yield and quality, and affect food safety, posing a health risk to humans. We reviewed the application of metal-based nanoparticles in inhibiting plant pathogenic bacteria and fungi, and discuss the antibacterial mechanisms of metal-based nanoparticles from two aspects: the direct interaction between nanoparticles and pathogens, and the indirect effects of inducing plant resilience to disease. © 2022 Society of Chemical Industry. |
36196679 | The relationship between organizational commitment and work engagement among clinical nurses in China: A cross-sectional study. | This study aims to investigate the levels of mitment and work engagement among clinical nurses in tertiary hospitals and explore the relationship between them. |
36196680 | Treatment endpoints for chronic hepatitis D. | Management of chronic hepatitis D (CHD) has entered a new era. In this new era, the virus entry inhibitor bulevirtide has received conditional approval as a treatment pensated CHD. Three phase 3 studies with two pounds are ongoing for the treatment of CHD. In this context, surrogate markers of treatment efficacy have been well defined for chronic hepatitis B (CHB) (7) and chronic hepatitis C (8) but not for CHD. The aim of this review is to give a perspective on treatment endpoints in CHD. For this, we took guidance from CHB studies and tried to make suggestions which differed according to finite versus prolonged treatment durations and also took into account the different characteristics of the pounds. |
36196681 | 'Trial by fire': An online survey exploring confidence of junior doctors in managing toxicology presentations to the emergency department. | The often unknown nature of acute drug intoxication, especially with illicit drugs and emerging novel psychoactive substances, can present a significant challenge for emergency clinicians. Less experienced clinicians are particularly vulnerable to the diagnostic dilemmas plex toxicology emergencies. We sought to better understand the confidence of junior doctors in assessing and managing toxicological emergencies across two emergency departments in Perth, Australia. |
36196682 | Photogenerated carrier dynamics at the B | Developing van der Waals (vdW) heterostructures is an excellent approach for optimizing exceptional optoelectronic and photocatalytic properties of materials; therefore, researching the interface dynamics of charge carriers at the two-dimensional vdW heterojunction is of great significance. In this work, we perform time-dependent |
36196683 | Correction: | Correction for ' |
36196684 | RNA-sequencing analysis reveals the potential molecular mechanism of RAD54B in the proliferation of inflamed human dental pulp cells. | To investigate the role of RAD54B in the proliferation of inflamed human dental pulp cells (hDPCs) induced by lipopolysaccharide (LPS). |
36196685 | Influence of airway trolley organization on efficiency and team performance: A randomized, crossover simulation study. | Failed management of unanticipated difficult airway situations contributes to significant anesthesia-related morbidity and mortality. Optimization of design and layout of difficult airway trolleys (DATs) may influence es during airway emergencies. The main objective of the current study was to evaluate whether a difficult airway algorithm-based DAT with integrated cognitive aids improves efficiency and team performance in difficult airway scenarios. |
36196686 | Base-triggerable lauryl sarcosinate-dodecyl sulfate catanionic liposomes: structure, biophysical characterization, and drug entrapment/release studies. | Equimolar mixtures of oppositely charged single-chain amphiphiles form a variety of phases, including vesicles. Such catanionic mixed lipid systems show high stability and exhibit versatile physicochemical properties. In the present study we have investigated the aggregation behaviour of lauryl sarcosinate hydrochloride (LS·HCl) in aqueous dispersion as well as its interaction with the anionic surfactant sodium dodecyl sulfate (SDS). The CMC of LS·HCl was estimated to be ∼5 mM by isothermal titration calorimetry (ITC) and fluorescence spectroscopy using pyrene as the fluorescent probe. Turbidimetric and ITC studies on the interaction of LS·HCl with SDS demonstrated that the two surfactants form an equimolar plex. The crystal structure of the lauryl sarcosinate-dodecyl sulfate plex revealed that plex is stabilized by classical N-H⋯O as well as C-H⋯O hydrogen bonds, besides the electrostatic attraction between LS (cation) and DS (anion) and dispersion interactions between the hydrocarbon chains. Differential scanning calorimetry studies revealed that the phase transition of the equimolar plex is significantly pared to the analogous LG-DS and plexes in the fully hydrated state. Dynamic light scattering, atomic force microscopy and transmission electron microscopy studies demonstrated that the LS-DS plex forms stable medium-sized vesicles (diameter of ∼300-500 nm). |
36196687 | Horizontal expansion of biicosahedral M | For metal nanoclusters with the "cluster of clusters" intramolecular evolution pattern, most efforts have been made towards the vertical superposition of icosahedral nanobuilding blocks ( |
36196688 | Long-term outcome of paediatric anti-N-methyl-D-aspartate receptor encephalitis. | To study long-term clinical and cognitive es of patients with anti-N-methyl-d-aspartate receptor encephalitis (NMDAR-E), an acute autoimmune neurological disease with severe acute presentations. |
36196690 | Retraction Note: LncRNA RUSC1-AS1 promotes the proliferation of breast cancer cells by epigenetic silence of KLF2 and CDKN1A. | The article "LncRNA RUSC1-AS1 promotes the proliferation of breast cancer cells by epigenetic silence of KLF2 and CDKN1A, by C.-C. Hu, Y.-W. Liang, J.-L. Hu, L.-F. Liu, J.-W. Liang, R. Wang, published in Eur Rev Med Pharmacol Sci 2019; 23 (15): 6602-6611-DOI: 10.26355/eurrev_201908_18548-PMID: 31378902" has been retracted by the authors. After publication, the article was questioned on PubPeer. Concerns were raised about Figure 2, Table I, and the reliability of the published results. The same authors stated that they want to rearrange the manuscript and provide readers with a more precise model. |
36196691 | The evolution of European legislation on doping: new challenges in the age of NPS. | The fight against doping in sport, formally started in 1960 with the constitution of the International Olympic Committee (IOC) and culminated in 1999 with the birth of the World Anti-Doping Agency missioned to chair various activities, including the publication of the annual list of prohibited substances and methods for doping. In Europe, as early as 1967, the Committee of Ministers of the Council of Europe adopted a resolution to stigmatise the intake of substances foreign to the body for the sole purpose of artificially and unfairly influencing sports performance. In 2002, the Council of Europe adopted an Additional Protocol to the 1989 Strasbourg Convention against Doping to ensure mutual recognition of doping controls and to strengthen the enforcement of the Convention. In Italy, the Law of 14 December 2000 n. 376 "Discipline of the health protection of sports activities and the fight against doping", defines doping as "the administration or intake of drugs or biologically or pharmacologically active substances and the adoption or submission to medical practices not justified by pathological conditions and suitable to modify the psychophysical or biological conditions of the organism in order to alter the athletic performance of athletes". The same law regulates the use of drugs or biologically or pharmacologically active substances and update an annual list in agreement with WADA. The article aims to analyse the legislation from a national perspective, offering plete a view as possible of the current situation. |
36196692 | Ethics of digital therapeutics (DTx). | Digital therapeutics (DTx) are a subset of digital health which are often coupled with artificial intelligence (A.I.) techniques and machine learning systems. DTx differ mon wellness apps or medication reminder tools in that they require "rigorous" clinical evidence. They are emerging as a new treatment option and are being applied in a variety of areas, including type II diabetes, hypertension, chronic respiratory problems, obesity, insomnia, Alzheimer's disease, various types of dementia or addiction (smoking, alcohol, drugs), anxiety, depression, autism, learning disabilities, and attention deficits. Today, there are roughly 35 to 40 products on the market, 8 of which approved by regulatory agencies. The value of the global DTx market was estimated at USD 1.8 billion in 2018, and it is expected to reach USD 8.9 billion by 2027. Implementing DTx across healthcare systems raises a number of ethical concerns. The present article aims to provide an overview of the main ethical issues pertaining the assessment, implementation, and use of this emerging technology. The final purpose is to support and facilitate an open and transparent deliberation with regard to DTx. |
36196693 | A literature review of hypertensive retinopathy: systemic correlations and new technologies. | Hypertensive retinopathy (HR) is the mon ocular manifestation of systemic arterial hypertension. This paper aims to summarize the current knowledge of HR, reviewing its classical features, such as epidemiology, pathophysiology, clinical manifestations, classifications, management and the most significant systemic correlations. We also provide an update on the latest advances in new technologies focusing on novel instrumental classifications. |
36196694 | Study on the application of the Internet + nursing service in family rehabilitation of common bone and joint diseases in the elderly. | To explore the feasibility of the Internet + nursing service mode in family rehabilitation of elderly patients with osteoarthritic diseases. |
36196695 | Hydration status assessment and impinging factors among university students in the UAE. | Insufficient water intake has been a global health concern as it is linked to numerous adverse health consequences. Risk factors for dehydration include low fluid intake, sun and heat exposure which is a key element especially in the Gulf region. The aim of this study was to identify the prevalence and the impinging factors of hypohydration among college students in UAE. |
36196696 | Correlation of mortality with Pro-BNP and precipitating factors of acute heart failure in patients presenting to a medical emergency of tertiary care hospital: an observational study from north India. | Acute heart failure is a syndrome defined as the new onset de novo heart failure or worsening [acutely pensated heart failure (ADHF)] leading to symptoms and signs of HF, mostly related to systemic congestion as based on the European Society of Cardiology (ESC) definition. India has a huge burden of heart failure patients. Several factors have been identified as precipitating acute HF hospitalizations. These include myocardial ischemia, no adherence to medications, arrhythmias, infection, uncontrolled hypertension (HTN), anemia, renal impairment, and diet. However, there is a dearth of studies assessing their effect on mortality in patients admitted with acute heart failure. Many previous studies have shown that BNP and NT-pro-BNP are independent predictors of mortality and other cardiac es in patients with heart failure (HF) and ADHF. However, no studies have provided any clear direction with respect to the critical cut-off values that suggest high mortality. Comprehensive knowledge of the correlation of Pro-BNP and precipitating factors of heart failure with mortality can help in prognostication and clinical management of AHF patients. |
36196697 | Systematic evaluation of influencing factors for Chinese rural doctors' job satisfaction and turnover intention: based on the two-factor theory. | In China, rural doctors (RDs) perform crucial health care missions. However, they have received less attention than their colleagues in urban public hospitals. In this specific group, a severe challenge occurs in sync with a high turnover rate and deficient job satisfaction. |
36196698 | A practical study regarding the effect of adaptive roller-skating on emotion regulation ability of autistic children. | Our aim is to analyze the effect of adaptive roller-skating on emotional regulation of autistic children. |
36196699 | Predictive value of immature granulocyte and delta neutrophil index in the diagnosis of complicated acute cholecystitis. | plicated gallbladder disorders are associated with increased mortality and morbidity. Thus, this study was aimed at evaluating the predictive value of immature granulocyte count and delta neutrophil index in the prediction plicated cholecystitis. |
36196700 | Gingerol fractions bioactivity against butanone cytotoxicity induced in newborns of mice. | Accumulating studies have demonstrated the potential activity of ginger in treating and managing several diseases but little is known about its protective effects against teratogenicity of chemical toxins. Thus, in this study, we have evaluated the protective effect of gingerol fraction (GF) against methyl ethyl ketone (MEK) induced teratogenic effects in newborns of mice. |
36196701 | Magnesium yields opposite effects on the nuclear and cytosolic cascades of apoptosis in different rat brain regions. | Magnesium is considered as potential neuroprotective and therapeutic agent, but certain studies have provided evidence of its apoptotic effectiveness in neurons. We aimed to evaluate the possible apoptotic effects of long-term magnesium use in healthy adult rat brains. |
36196702 | Abnormal hyperplasia of chondrocytes in a rat model of glucocorticoid-induced osteonecrosis of the femoral head. | The aim of our study was to determine whether abnormal hyperplasia of chondrocytes occurs in glucocorticoid-induced osteonecrosis of the femoral head (GC-ONFH) using a well-established rat model. |
36196703 | CBCT based study to analyze and classify root canal morphology of maxillary molars - A retrospective study. | The study aims to evaluate maxillary molars' root and root canal morphology among the Saudi population using Cone-Beam Computed Tomography scanning (CBCT). |
36196704 | Awareness of current mobile apps for smoking cessation among the dental and medical practitioners in Saudi Arabia. | This study aimed at assessing whether the dental and medical practitioners in Saudi Arabia are aware of the smoking cessation smartphone applications and their opinions about this method used in smoking cessation. |
36196705 | Young's syndrome, a rare syndrome that can cause infertility and mimics cystic fibrosis and immotile-cilia syndrome: a case report. | Young's syndrome (YS) is a rare, inherited monly seen in middle-aged men with chronic rhinosinusitis, nasal polyps, decreased fertility due to azoospermia, and bronchiectasis. In this paper, we present a case of YS of unknown cause together with a literature review. |
36196706 | The pathophysiological role of inflammatory parameters in patients with varicocele. | Varicocele is the abnormal enlargement of the pampiniform plexus in the scrotum and is one of the diseases that have negative consequences on reproduction in men today. The aim of this study is to investigate the pathophysiological role of inflammatory parameters in patients diagnosed with varicocele. |
36196707 | Effects of a combination of resveratrol and alpha-lipoic acid on body weight and adipose composition in women with PCOS: a preliminary pilot study. | Polycystic ovary syndrome is associated with reproductive and metabolic dysfunction; in fact, treatment aims in PCOS focus on optimizing healthy weight, improving underlying hormonal disturbances, preventing future reproductive and plications, and improving quality of life. |
36196708 | Impact of Enoxaparin +α Lipoic acid combination on oxidative stress, follicle development and apoptotic damage in ovarian ischemia reperfusion model. | With this study we aimed at investigating the impact of enoxaparin (E) and α-lipoic acid (α-LA) on ischemia/reperfusion (I/R) damage in an experimental ovarian torsion (T) detorsion (D) model. |
36196709 | DNA repair gene (XRCC1 and XPD) polymorphism and risk of primary ovarian failure. | DNA repair genes may be related with the onset of primary ovarian failure (POF). The study was planned to investigate whether the polymorphisms in the DNA repair genes modulate the risk of POF. |
36196710 | Association between asymptomatic hyperuricemia and knee osteoarthritis in older outpatients. | To investigate the association between asymptomatic hyperuricemia and knee osteoarthritis in older outpatients in Vietnam. |
36196711 | Effects of adding hypertonic saline solutions and/or etilefrine to standard diuretics therapy in cirrhotic patients with ascites. | The renin-angiotensin-aldosterone system (RAAS) activation is the milestone in ascites formation. Hypertonic saline solution (HSS) has attracted considerable interest over the last years in ascites control. Other therapeutic models and concepts have been introduced to e diuretic resistance and control ascites. We aimed to evaluate the effects of adding HSS infusion and/or etilefrine to oral diuretics therapy on inflammatory and metabolic pathways, renal and systemic hemodynamics, and clinical es by estimating the changes in selected biochemical and biological markers in cirrhotic patients with ascites. |
36196712 | Diffusion-weighted imaging of the liver in assessing chronic liver disease: effects of fat and iron deposition on ADC values. | This study was designed to evaluate whether fat and iron affect the apparent diffusion coefficient (ADC) values of the liver parenchyma in the settings of fibrosis and inflammation. |
36196713 | An alternative method for measuring total respiratory resistance during quiet breathing: a feasibility and validation study. | Determining the respiratory system's mechanical properties with minimal patient effort has been an important field of investigation addressing patients unable to perform pulmonary function testing and in light of the preventive measures due to the recent pandemic. The current study aimed to present an alternative method for total respiratory resistance measurement during tidal pare it with airway resistance (Raw), measured by body plethysmography, and validate the procedure in three groups of subjects with normal, constrictive and obstructive respiratory patterns in spirometry. |
36196714 | The diagnostic values of lung ultrasound for ARDS. | Acute respiratory distress syndrome (ARDS) is a critical monly found in many clinical cases, with a mortality rate of approximately 50%. Early diagnosis and intervention are important for improving ARDS prognosis. In this study, the applications of lung ultrasound in ARDS diagnosis and assessment are reviewed to clarify its key clinical values and application prospects. |
36196715 | An intubation method for mono-pulmonary ventilation in patients with difficult airway. | This study aimed pare the clinical effect between thermal softening PVC double-lumen tube (DLT) and single-lumen tube (SLT) guided by laryngoscope and bronchoscopy in patients with difficult airways. |