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This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | It is possible that qualified doctors were more likely to recognize the potential seriousness of AFI, and warn patients of the possible need for escalation. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Cases 11, 12, and 13 had no current symptoms of bone disease but there was severe reduction in bone mineral density and a potential increase in these individuals’ lifetime risk of fracture. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Self-reported snoring and snorting/gasping each provide an aspect of sleep apnea. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Patients have identified under-staffing, poor physical facilities, behavior of service providers, and inability to provide essential medicines directly as causes of this low opinion. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Indeed, the data shows that humans stop expanding a branch of the model once they encounter a large punishment. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Early detection and prevention are the most important control strategies of cancer in the twenty-first century. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Numerous studies have attempted to identify useful biomarkers for HCA through the analyses of amniotic fluid and maternal blood [11], [23]–[25]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Six case-control studies showed that dietary intake or serum levels of either lutein only30–32 or lutein/zeaxanthin33–35 were not associated with CRC risk. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In particular, we showed the activation of two distinct apoptotic pathways which could be proved to be an important contribution of the development of CRS Type 5 and might play a role in the pathophysiological mechanism of this syndrome. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | To maintain mobility in vertebrae that have not been grafted, in our study removing the metal is only indicated with long-segment dorsal instrumentation after ventral bony regrowth in the lumbar spinal region [12]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Education potentially provides opportunities for employment and social support, and thus can contribute to a sense of good QoL. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | vur is equal to zero for γ-values of zero and one, and reaches a maximum for an intermediate value of γ (its exact value depends on other parameters). |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In addition, diagnosis of HCA through histologic examination of the placenta is possible only after delivery; thus, the method is not suited for rapid prenatal diagnosis of intrauterine inflammation, nor can it be used in neonatal treatment in patients diagnosed with neonatal sepsis. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Changes in infragranular cortex are consistent with the literature. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We have previously described that Indian children had smaller birth sizes and lower BMI in infancy compared to Chinese children28; this may potentially explain the relationship between Indian ethnicity and a low BMIz trajectory, which is the result of BMI tracking. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We found that patients in the PA group reported having less limping than patients in the LA group, which may be explained by the disturbance of the abductor muscles (Masonis and Bourne 2002, Edmunds and Boscainos 2011, Amlie et al 2014). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The most common sensory deficit was vestibular, with 36% scoring in the abnormal range (Fig. 1). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In that study, the SYS and NED groups both contained 213 individuals. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | To our knowledge, this is the first study showing that local TNF contributes to lipid-mediated podocyte injury in FSGS and DKD by a dual mechanism that requires both reduced ABCA1 expression and reduced SOAT1 activity. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | LUMA assesses methylation of a specific restriction enzyme site (HpaII, CCGG), which occurs most frequently in CpG island promoters – also covered by the 450 K array – but also in repetitive elements. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In support of the hypothesis that these relationships are driven by direct competition for energetic resources, negative associations between specific measures of immunity and growth were stronger when involving more costly forms of immune function and were evident only when examined over timeframes corresponding to synchronous energy use. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The retrospective nature of our present study did not allow us to specify the form of postoperative pain control and compare opioid demand. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Therefore, preoperative use of gabapentin may have a place in the treatment of postoperative pain (Dahl, Mathiesen, & Moiniche, 2004; Ho, Gan, & Habib, 2006; Milch, 2005) and has been given as a single dose (Dirks et al., 2002; Hurley, Cohen, Williams, Rowlingson, & Wu, 2006; Rorarius et al., 2004) or as an adjunct to epidural analgesia (Turan, Kaya, Karamanlioglu, Pamukcu, & Apfel, 2006). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Adolescence is accompanied by rapid and varied changes in physical growth, sexual maturity, hormone levels, and psychological issues [33], [34]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The extreme weakness or apparent absence of one acetabular wall represents the only absolute contraindication for the use of this threaded component. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This was necessary to avoid the pitfall of only including data of persons who could perform the measure, which would have biased the results towards those with a better outcome. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Furthermore, the tendency of parathyroid hormone to reduce serum phosphate will decrease the calcium:phosphate product,20 further diminishing one of the important driving forces for mineralisation of bone osteoid. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In 13 cases the displayed pH value was more than 8.00, and in seven cases the display showed only -. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The pathways paired in predicting for distant metastasis were the xenobiotic metabolism and integrin-linked kinase (ILK) signaling pathways. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Metabolic bone disease remains a significant and common complication of coeliac disease. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | There may also be additional confounding factors we did not consider but that still affected the FA-BSID relationships. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our study is a retrospective analysis of returned questionnaires. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Multimodal pain therapy is effective (Citation, 2005), and a multimodal approach that incorporates newer therapies is generally accepted in clinical practice. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We hope that these findings can stimulate further research on prayer in the field of CP clarifying the possible role of personal religious activities in the pain management of patients. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This N400 abnormality was not present in a parallel non-verbal part of the experiment where object pictures were matched to other object pictures. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In a study by Przkora et al of oxandrolone and exercise in pediatric burn patients, it was reported that both the subjects with exercise training and subjects with oxandrolone and exercise training had significantly increased peak oxygen consumption [16]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | There are a number of anatomic and behavioral differences that exist between the rat and human. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Thus, our measures in the rat model provide important insights that may further our understanding of Parkinson disease, the process of aging, and the influence of these on the intricate act of deglutition. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Anatomical differences relevant to deglutition between the rat and human are found in the oral cavity, pharynx and larynx. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | All of these consequences were more common for poorer households. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In contrast, loss-of-function defects consistently occur in only a subset of periodic paralysis: those with features of hypokalemic periodic paralysis (HypoPP) due to mutations in Nav1.4 (28, 29). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In particular, it is apparent that those who benefited the most from the intervention were those who were younger, those who did not have diabetes, those who had uncontrolled DBP at baseline, those who reported low salt intake, and those on fewer antihypertensive medications. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our observation may be similar to Maria’s. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The discovery and description of the mechanisms by which BIM, as well as other oncosuppressors, are inactivated in specific types of cancers may be of great importance to define evidence-based cancer treatment protocols. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Nevertheless, the success rates of these medical treatments have peaked at 70-80% (10, 20), and the relapse rate in patients with sputum conversion at the completion of medical treatment is high (21). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Therefore, the data need validation in a larger multicenter confirmatory trial. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Implications for nosology Although this study is not about semantic PPA or semantic dementia, it should be pointed out that the semantic variant of PPA, in fully developed or possibly prodromal form, was detected in 7 of 11 patients and comprised the single largest diagnostic group. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | These mutations are independently distributed and heterozygosity for SLC4A1Δ27 does not influence heterozygosity or homozygosity for GYPCΔex3. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In the present study, we focused on the possibility that ANP indirectly inhibits tumor cell metastases through effects on nontumor cells. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our replication of the obesity association of deletions including SH2B1 and the finding of limited evidence to support 2 further associations, together with recent successes in other disorders including attention deficit hyperactivity disorder [43], demonstrate that analysis of carefully-selected cohorts has the potential to reveal novel, rare, causal GSVs. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Osteointegration of the grit-blasted titanium surface is excellent and provides rapid secondary stability. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Not surprisingly, the no-hormonal therapy group functioned psychologically worse than the hormonal therapy group (the Schizophrenia and Masculinity/Femininity scales in the FtMs, and the Psychasthenia and Hypomania scales in the FtMs). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The different association between both availability and accessibility of different food vendors with cardiovascular risk factor in different countries may be due to various social, cultural, economic factors which affect food sale, purchasing and consumption patterns (Turner et al, 2019). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | No more than 5% of the patients referred to our department for myocardial perfusion SPECT are unable to complete this examination in the biker position, mostly because of extreme physical exhaustion or hip problems hampering their sitting astride the camera armchair. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | As in other settings, only those patients likely to suffer mortality or substantial morbidity due to their disease should be considered for aggressive treatment, which should only be offered in the setting of an institutional-review-board-approved clinical trial or prospective registry. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In our survey, a high proportion (70.7%) of the HCSs, enrolled in the study at the preventive medical examination, had persistence of seroprotective levels against HBV after more than 20 y since the administration of primary vaccination course. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Besides the significant increase of members of Ruminococcaceae spp. and Bifidobacteriaceae spp., our findings also showed a significant decrease of two representatives from the Lachnospiraceae family under walnut consumption. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Oxford House settings should not only be thought of as developing new reference groups, but also new family units, and this involves far more extensive interactions than mere social contact. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Future efforts should take into account newer guidelines, the cost-benefit aspects, and the Hawai‘i-specific resources. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Antioxidant activity neutralizes the ROS and negates the effect on fertilization and cleavage rates in the first two cleavage divisions. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The inferably suppressive effect of E2 versus placebo on ACTH secretion was confirmed by E2 concentration-dependent inhibition of ACTH secretion both in the combined cohort (48 adults) and in the women's cohort alone (n = 24). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The lung seems to be the target organ for SARS-CoV-2, and patients may develop acute lung injury and ARDS upon infection. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Multiple multivariable adjusted logistic regressions analyses supported the roles of sleep habits, including sleep duration, daytime napping, snoring, snorting/gasping as significant risk factors for all stoke, ischemic stroke and hemorrhagic stroke. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Blinding of both the patients and the principal investigator performing the analyses was maintained almost completely throughout the trial, due to the nature of the self-reported outcomes and through the discretion of the hospital personnel. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Significant increases in the abundance of Bifidobacterium spp. and Lactobacillus spp. could also be observed in fecal samples as a consequence of both raw almond and almond skin supplementation [47]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | It was reported in this study that slightly more than one-quarter of the participants (29.4%) practised self-medication with analgesics. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | HMGB1 and IL-6 are involved in the pathogenesis of pandemic H1N1 influenza-associated encephalopathy, and the levels of these inflammatory cytokines in serum can be used as biomarkers for inflammation severity [citation]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, there is no consensus about the optimal combination regimen, and a systematic comparison of regimens is needed. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, if BMD is known, the clinical utility of these genetic risk scores for fracture prediction is limited in older adults. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The short chain fatty acid butyric acid is generated from fermentation of indigestible polysaccharides [30] and provides energy for intestinal epithelial cells and contributes to host health by facilitating maintenance of colon epithelial integrity and controlling inflammatory processes [31,32]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | When planning the study, we considered it as problematic from an ethical viewpoint to withhold these potent prophylactic regimes from the study participants at increased risk of CIN. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Increased attention must be paid to the metabolic, inflammatory, and hormonal pathways shaping obesity that interact with structural causes of poor energy balance [17]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Similarly, metastasis-directed therapies such as SBRT carry a low risk of toxic effects and provide excellent local control. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | BMI may actually predict sedentary behavior [20]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This issue is relevant because it is unknown whether cardiac vein branches not visualized were not present because of venous anatomic variation or present but not visualized. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This case series further develops the efficacy profile of RTX and supports cyclophosphamide avoidance in appropriate patients by providing a rationale for use of a reduced dosing regimen of RTX in persistent pulmonary granulomatous inflammation. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our study adds to the growing evidence that untreated HIV-1 infection in men is associated with genital compartment inflammation. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Nearly half patients (74/146) have hypokalemia in our study, but we found there was a linear relationship between LogARR and serum potassium. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The procedure may reinforce gender affirmation with better social recognition. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | A history of three well-defined previous episodes of depression within the last 5 years before study inclusion is required to obtain a patient sample with sufficient predicted morbidity to provide reasonable power for a comparison of relapse (Montgomery and Kasper, 1998). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This compared to rates in the literature obtained in 31,000 children of 12.1% for children aged 6 to 11 months and 1.1% for children aged 4 years 18. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Likewise, the effects of maternal separation and temperature exposure in their respective impact on endocrine, morphological and behavioral changes will have to be differentiated. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In any case, our results on NGAL values and its connection with outcome were limited for the small size of the study: in fact, a minimum of 25 events are required to draw reliable conclusion in case of outcome analysis. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Second, more ETC + navigation participants who had initially said that they did not have a time frame in mind for quitting reported that they now had a time frame in mind for quitting, relative to ETC-control participants (37% vs. 7%). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Unlike typically found for “handled” rat, the animals in the study by Gibbs and Kolb did not show behavioral improvements by adulthood. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Because most current chemotherapeutic agents are cytotoxic and cause many side effects, chemotherapy cannot be used during surgical resection to prevent cancer recurrence. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Commensurate with this more pronounced defect in excitability, the leftward (hyperpolarized) shift for inactivation was much greater for V1442E (-30 mV, Fig. 5A) than the -10 mV shift observed for R672 mutants in HypoPP. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In conclusion, despite its relatively high surgical complication rate, patients with NTM lung disease whose disease is localized to one lung and who can tolerate resectional surgery might be considered for surgery, if there has been a poor response to drug therapy or if the patients develop significant disease-related complications such as hemoptysis. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Thus, once introduced in animals, carbapenemase genes may be coselected by the use of other classes of antibiotics, which could increase the prevalence of CPE in animals. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The level of CEAs reflects the degree of cancer disease and provides a reference for the diagnosis of the distant‐stage disease, evaluation of the prognosis, and monitoring the recurrence during the follow‐up 25, 26. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The use of aprotinin has been linked with a higher incidence of both perioperative myocardial infarction and early vein graft closure 26. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | By applying the modified TSP approach to analyze the reported data from the largest retrospective study to date that has evaluated for an association between gene expression in primary tumor and disease progression after RRP, we identified two pairs of genes whose relative expression predicts such tumor progression. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This finding has policy and practical implications. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Since 1999, psychological interventions (guided imagery, distraction, self hypnosis) have been introduced by a clinical psychologist during one session 5 to 10 days before LSS; patients and family members were then encouraged to practice on their own the specific interventions as taught by the psychologist. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Additionally, the P-values for the trend analysis reflected a positive association with atopic dermatitis. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We recommend that dentists should refer to relevant guidelines on prescribing analgesics for dental pain [28,29]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Similar caveats should perhaps also be attached to the growing number of studies investigating common GSVs [36], [37], [39]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, study conditions are hardly comparable due to the different walnut serving sizes and varying study durations. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Moreover, the distribution of peripheral B-cell patterns among AFM was similar to that among IPH and IgGSD patients and indicated that some AFM have a defect in later stages of peripheral B-cell development. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Isolates from PO10-3 had an additional carbapenemase gene, blaNDM-5. |