id
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2 classes
annotations
list
21887897_2
A fatal poisoning case involving etizolam, phenobarbital, promethazine and chlorpromazine is presented.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"involving\"]], \"start\": [[23]], \"entity_id\": [\"T9\"]}, \"Treatment\": {\"text\": [[\"etizolam, phenobarbital, promethazine and chlorpromazine\"]], \"start\": [[33]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"etizolam\"], [\"phenobarbital\"], [\"promethazine\"], [\"chlorpromazine\"]], \"start\": [[33], [43], [58], [75]], \"entity_id\": [\"T12\", \"T13\", \"T14\", \"T15\"]}}, \"Effect\": {\"text\": [[\"A fatal poisoning\"]], \"start\": [[0]], \"entity_id\": [\"T8\"]}, \"Subject\": {\"text\": [[\"A fatal poisoning case\"]], \"start\": [[0]], \"entity_id\": [\"T10\"]}, \"Severity\": {\"text\": [[\"fatal\"]], \"start\": [[2]], \"entity_id\": [\"T11\"], \"value\": \"Medium\"}}" } ] } ]
19116715_3
Rituximab-based therapy for gemcitabine-induced hemolytic uremic syndrome in a patient with metastatic pancreatic adenocarcinoma: a case report.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[40]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"gemcitabine\"]], \"start\": [[28]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"gemcitabine\"]], \"start\": [[28]], \"entity_id\": [\"T8\"]}, \"Disorder\": {\"text\": [[\"metastatic pancreatic adenocarcinoma\"]], \"start\": [[92]], \"entity_id\": [\"T9\"]}}, \"Effect\": {\"text\": [[\"hemolytic uremic syndrome\"]], \"start\": [[48]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"patient with metastatic pancreatic adenocarcinoma\"]], \"start\": [[79]], \"entity_id\": [\"T6\"]}}" } ] } ]
19390192_1
Leukopenia due to parvovirus B19 in a Crohn's disease patient using azathioprine.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"due\"]], \"start\": [[11]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Leukopenia\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Subject\": {\"text\": [[\"parvovirus B19 in a Crohn's disease patient\"]], \"start\": [[18]], \"entity_id\": [\"T5\"], \"Disorder\": {\"text\": [[\"parvovirus B19\"]], \"start\": [[18]], \"entity_id\": [\"T1\"]}}, \"Treatment\": {\"text\": [[\"azathioprine\"]], \"start\": [[68]], \"entity_id\": [\"T6\"], \"Disorder\": {\"text\": [[\"Crohn's disease\"]], \"start\": [[38]], \"entity_id\": [\"T7\"]}, \"Drug\": {\"text\": [[\"azathioprine\"]], \"start\": [[68]], \"entity_id\": [\"T8\"]}}}" } ] } ]
1477441_3
Fixed drug eruption of the scrotum due to methylphenidate.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"due\"]], \"start\": [[35]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Fixed drug eruption of the scrotum\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"methylphenidate\"]], \"start\": [[42]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"methylphenidate\"]], \"start\": [[42]], \"entity_id\": [\"T6\"]}}}" } ] } ]
3470173_2
Cytarabine-induced cerebellar syndrome: case report and literature review.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[11]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"Cytarabine\"]], \"start\": [[0]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"Cytarabine\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"cerebellar syndrome\"]], \"start\": [[19]], \"entity_id\": [\"T5\"]}}" } ] } ]
10513720_2
We report a case of glaucoma induced by doxetaxel therapy for metastatic breast cancer.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[29]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"a case\"]], \"start\": [[10]], \"entity_id\": [\"T3\"]}, \"Effect\": {\"text\": [[\"glaucoma\"]], \"start\": [[20]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"doxetaxel therapy for metastatic breast cancer\"]], \"start\": [[40]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"doxetaxel\"]], \"start\": [[40]], \"entity_id\": [\"T9\"]}, \"Disorder\": {\"text\": [[\"metastatic breast cancer\"]], \"start\": [[62]], \"entity_id\": [\"T7\"]}}}" } ] } ]
8301877_3
Myoclonus was induced and enhanced by L-dopa, developing into generalized seizures.
false
[ { "events": [ { "event_id": "E2", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E2\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced and enhanced\"]], \"start\": [[14]], \"entity_id\": [\"T9\"]}, \"Treatment\": {\"text\": [[\"L-dopa\"]], \"start\": [[38]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"L-dopa\"]], \"start\": [[38]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"developing into generalized seizures\", \"Myoclonus\"]], \"start\": [[46, 0]], \"entity_id\": [\"T8\"]}}" } ] } ]
15494638_4
During analysis of 28 patients receiving CAP with concomitant radiation (XRT) for pancreatic cancer (resected or locally advanced), two patients developed signs and symptoms consistent with peripheral neuropathy.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[145]], \"entity_id\": [\"T11\"]}, \"Treatment\": {\"text\": [[\"CAP with concomitant radiation (XRT)\"]], \"start\": [[41]], \"entity_id\": [\"T9\"], \"Disorder\": {\"text\": [[\"pancreatic cancer\"]], \"start\": [[82]], \"entity_id\": [\"T10\"]}, \"Drug\": {\"text\": [[\"CAP\"]], \"start\": [[41]], \"entity_id\": [\"T14\"]}, \"Route\": {\"text\": [[\"concomitant radiation\"]], \"start\": [[50]], \"entity_id\": [\"T15\"]}}, \"Subject\": {\"text\": [[\"two patients\"]], \"start\": [[132]], \"entity_id\": [\"T8\"], \"Population\": {\"text\": [[\"two\"]], \"start\": [[132]], \"entity_id\": [\"T13\"]}}, \"Effect\": {\"text\": [[\"peripheral neuropathy\"]], \"start\": [[190]], \"entity_id\": [\"T12\"]}}" } ] } ]
25515435_8
A liver biopsy in 2012 revealed marked fibrosis, leading the patient to start hepatitis C treatment with peginterferon alfa-2a, ribavirin and boceprevir.
true
[ { "events": [ { "event_id": "E1", "event_type": "Potential_therapeutic_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"treatment\"]], \"start\": [[90]], \"entity_id\": [\"T10\"]}, \"Subject\": {\"text\": [[\"fibrosis, leading the patient\"]], \"start\": [[39]], \"entity_id\": [\"T9\"]}, \"Treatment\": {\"text\": [[\"peginterferon alfa-2a, ribavirin and boceprevir\"]], \"start\": [[105]], \"entity_id\": [\"T11\"], \"Disorder\": {\"text\": [[\"fibrosis\"]], \"start\": [[39]], \"entity_id\": [\"T8\"]}, \"Drug\": {\"text\": [[\"peginterferon alfa-2a\"], [\"ribavirin\"], [\"boceprevir\"]], \"start\": [[105], [128], [142]], \"entity_id\": [\"T12\", \"T13\", \"T14\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"and\"]], \"start\": [[138]], \"entity_id\": [\"T15\"]}, \"Drug\": {\"text\": [[\"ribavirin\"], [\"boceprevir\"], [\"peginterferon alfa-2a\"]], \"start\": [[128], [142], [105]], \"entity_id\": [\"T13\", \"T14\", \"T12\"]}}]}}" } ] } ]
15494638_19
Knowledge regarding potential adverse effects of CAP is paramount and dose modification is indicated with development of neurotoxicity.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"adverse effects\"]], \"start\": [[30]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"CAP\"]], \"start\": [[49]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"CAP\"]], \"start\": [[49]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"neurotoxicity\"]], \"start\": [[121]], \"entity_id\": [\"T7\"]}, \"Speculated\": {\"text\": [[\"potential\"]], \"start\": [[20]], \"entity_id\": [\"T9\"], \"value\": true}}" } ] } ]
11111942_2
We present a case of significant over-anticoagulation temporally associated with a bout of protracted diarrhea in a patient on warfarin therapy.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"over-anticoagulation\"]], \"start\": [[33]], \"entity_id\": [\"T7\"]}, \"Effect\": {\"text\": [[\"protracted diarrhea\"]], \"start\": [[91]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"warfarin\"]], \"start\": [[127]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"warfarin\"]], \"start\": [[127]], \"entity_id\": [\"T8\"]}}}" } ] } ]
11160777_1
New oral therapies for type 2 diabetes mellitus:
false
[ { "events": [ { "event_id": "E1", "event_type": "Potential_therapeutic_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"for\"]], \"start\": [[19]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"oral therapies\"]], \"start\": [[4]], \"entity_id\": [\"T3\"], \"Disorder\": {\"text\": [[\"type 2 diabetes mellitus\"]], \"start\": [[23]], \"entity_id\": [\"T4\"]}, \"Route\": {\"text\": [[\"oral\"]], \"start\": [[4]], \"entity_id\": [\"T7\"]}}}" } ] } ]
10679548_3
The case histories are presented of two patients who developed lung disease associated with the use of nitrofurantoin with histological features of bronchiolitis obliterans organising pneumonia (BOOP), a rare but recognised form of drug induced injury.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[53]], \"entity_id\": [\"T10\"]}, \"Treatment\": {\"text\": [[\"the use of nitrofurantoin\"]], \"start\": [[92]], \"entity_id\": [\"T8\"], \"Drug\": {\"text\": [[\"nitrofurantoin\"]], \"start\": [[103]], \"entity_id\": [\"T12\"]}}, \"Subject\": {\"text\": [[\"two patients\"]], \"start\": [[36]], \"entity_id\": [\"T7\"], \"Population\": {\"text\": [[\"two\"]], \"start\": [[36]], \"entity_id\": [\"T11\"]}}, \"Effect\": {\"text\": [[\"lung disease\", \"with histological features of bronchiolitis obliterans organising pneumonia (BOOP)\"]], \"start\": [[63, 118]], \"entity_id\": [\"T9\"]}}" } ] } ]
7226916_1
A 57-year-old woman with right bundle branch block +LPH and ventricular premature contractions developed complete heart block (CHB) following administration of disopyramide phosphate (Norpace).
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[95]], \"entity_id\": [\"T8\"]}, \"Subject\": {\"text\": [[\"A 57-year-old woman with right bundle branch block +LPH and ventricular premature contractions\"]], \"start\": [[0]], \"entity_id\": [\"T7\"], \"Age\": {\"text\": [[\"57-year-old\"]], \"start\": [[2]], \"entity_id\": [\"T11\"]}, \"Gender\": {\"text\": [[\"woman\"]], \"start\": [[14]], \"entity_id\": [\"T12\"]}, \"Disorder\": {\"text\": [[\"right bundle branch block +LPH\"], [\"ventricular premature contractions\"]], \"start\": [[25], [60]], \"entity_id\": [\"T13\", \"T14\"]}}, \"Effect\": {\"text\": [[\"complete heart block (CHB)\"]], \"start\": [[105]], \"entity_id\": [\"T9\"]}, \"Treatment\": {\"text\": [[\"disopyramide phosphate (Norpace)\"]], \"start\": [[160]], \"entity_id\": [\"T10\"], \"Drug\": {\"text\": [[\"disopyramide phosphate\"]], \"start\": [[160]], \"entity_id\": [\"T15\"]}}}" } ] } ]
14700673_3
METHODS: In an institutional practice setting, two women, aged 25 and 45, developed acute myopia after starting topiramate for epilepsy.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[74]], \"entity_id\": [\"T4\"]}, \"Subject\": {\"text\": [[\"two women, aged 25 and 45\"]], \"start\": [[47]], \"entity_id\": [\"T3\"], \"Population\": {\"text\": [[\"two\"]], \"start\": [[47]], \"entity_id\": [\"T8\"]}, \"Gender\": {\"text\": [[\"women\"]], \"start\": [[51]], \"entity_id\": [\"T9\"]}, \"Age\": {\"text\": [[\"aged 25 and 45\"]], \"start\": [[58]], \"entity_id\": [\"T10\"]}}, \"Effect\": {\"text\": [[\"acute myopia\"]], \"start\": [[84]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"topiramate\"]], \"start\": [[112]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"topiramate\"]], \"start\": [[112]], \"entity_id\": [\"T11\"]}, \"Disorder\": {\"text\": [[\"epilepsy\"]], \"start\": [[127]], \"entity_id\": [\"T12\"]}}}" } ] } ]
16411025_2
Diffusion-weighted MRI correlates of subacute methotrexate-related neurotoxicity.
false
[ { "events": [ { "event_id": "E2", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E2\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"related\"]], \"start\": [[59]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"subacute\", \"neurotoxicity\"]], \"start\": [[37, 67]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"methotrexate\"]], \"start\": [[46]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"methotrexate\"]], \"start\": [[46]], \"entity_id\": [\"T3\"]}}}" } ] } ]
16298824_3
ARDS is rarely associated with rituximab infusion for lympho-proliferative disorders, but it should be considered by those administering rituximab, especially when a patient develops severe pulmonary symptoms soon after infusion.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[214]], \"entity_id\": [\"T8\"]}, \"Subject\": {\"text\": [[\"a patient\"]], \"start\": [[164]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"ARDS\", \"severe pulmonary symptoms\"]], \"start\": [[0, 183]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"infusion\"], [\"rituximab\"]], \"start\": [[220], [137]], \"entity_id\": [\"T9\", \"T10\"], \"Route\": {\"text\": [[\"infusion\"]], \"start\": [[220]], \"entity_id\": [\"T13\"]}, \"Drug\": {\"text\": [[\"rituximab\"]], \"start\": [[137]], \"entity_id\": [\"T11\"]}}}" } ] } ]
7351000_3
Seven of the eight cases of acute leukemia occurred in a series of 553 patients treated with Treosulfan for ovarian cancer in the period from 1970 to 1977 and followed closely for a total of 1159 patient-years up to February 1978.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"occurred\"]], \"start\": [[43]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"acute leukemia\"]], \"start\": [[28]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"Treosulfan\"]], \"start\": [[93]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"Treosulfan\"]], \"start\": [[93]], \"entity_id\": [\"T10\"]}, \"Disorder\": {\"text\": [[\"ovarian cancer\"]], \"start\": [[108]], \"entity_id\": [\"T11\"]}}, \"Subject\": {\"text\": [[\"Seven of the eight cases\"]], \"start\": [[0]], \"entity_id\": [\"T6\"], \"Population\": {\"text\": [[\"eight\"]], \"start\": [[13]], \"entity_id\": [\"T7\"]}}}" } ] } ]
6833205_2
Desipramine-associated SIADH in an elderly woman: case report.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[12]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"Desipramine\"]], \"start\": [[0]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"Desipramine\"]], \"start\": [[0]], \"entity_id\": [\"T9\"]}}, \"Effect\": {\"text\": [[\"SIADH\"]], \"start\": [[23]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"an elderly woman\"]], \"start\": [[32]], \"entity_id\": [\"T6\"], \"Age\": {\"text\": [[\"elderly\"]], \"start\": [[35]], \"entity_id\": [\"T7\"]}, \"Gender\": {\"text\": [[\"woman\"]], \"start\": [[43]], \"entity_id\": [\"T8\"]}}}" } ] } ]
16146480_1
Can propofol precipitate pancreatitis in patients with Cushing's syndrome?
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"precipitate\"]], \"start\": [[13]], \"entity_id\": [\"T4\"]}, \"Subject\": {\"text\": [[\"patients with Cushing's syndrome?\"]], \"start\": [[41]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"propofol\"]], \"start\": [[4]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"propofol\"]], \"start\": [[4]], \"entity_id\": [\"T8\"]}, \"Disorder\": {\"text\": [[\"Cushing's syndrome\"]], \"start\": [[55]], \"entity_id\": [\"T10\"]}}, \"Effect\": {\"text\": [[\"pancreatitis\"]], \"start\": [[25]], \"entity_id\": [\"T6\"]}, \"Speculated\": {\"text\": [[\"Can\"]], \"start\": [[0]], \"entity_id\": [\"T9\"], \"value\": true}}" } ] } ]
23552010_3
This case presents the possibility of anaphylaxis to topical 5-FU treatments and/or the interaction with angiotensin converting enzyme inhibitors.
true
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"to\"]], \"start\": [[50]], \"entity_id\": [\"T9\"]}, \"Effect\": {\"text\": [[\"anaphylaxis\"]], \"start\": [[38]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"5-FU\", \"angiotensin converting enzyme inhibitors\"]], \"start\": [[61, 105]], \"entity_id\": [\"T8\"], \"Drug\": {\"text\": [[\"5-FU\"], [\"angiotensin converting enzyme inhibitors\"]], \"start\": [[61], [105]], \"entity_id\": [\"T10\", \"T11\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"interaction\"]], \"start\": [[88]], \"entity_id\": [\"T12\"]}, \"Drug\": {\"text\": [[\"angiotensin converting enzyme inhibitors\"], [\"5-FU\"]], \"start\": [[105], [61]], \"entity_id\": [\"T11\", \"T10\"]}}]}, \"Speculated\": {\"text\": [[\"possibility\"]], \"start\": [[23]], \"entity_id\": [\"T13\"], \"value\": true}}" } ] } ]
15331204_8
After stopping indapamide, glucose tolerance impairing may be reversed.
false
[ { "events": [ { "event_id": "E1", "event_type": "Potential_therapeutic_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"stopping\"]], \"start\": [[6]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"indapamide, glucose tolerance impairing\"]], \"start\": [[15]], \"entity_id\": [\"T5\"], \"Disorder\": {\"text\": [[\"glucose tolerance impairing\"]], \"start\": [[27]], \"entity_id\": [\"T3\"]}, \"Drug\": {\"text\": [[\"indapamide\"]], \"start\": [[15]], \"entity_id\": [\"T9\"]}}, \"Speculated\": {\"text\": [[\"may\"]], \"start\": [[55]], \"entity_id\": [\"T7\"], \"value\": true}}" } ] } ]
11424102_3
We describe a case of needle-track cutaneous seeding of hepatocellular carcinoma (HCC) after sonographically guided percutaneous ethanol injection (PEI).
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[87]], \"entity_id\": [\"T7\"]}, \"Effect\": {\"text\": [[\"needle-track cutaneous seeding of hepatocellular carcinoma\"]], \"start\": [[22]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"sonographically guided percutaneous ethanol injection\"]], \"start\": [[93]], \"entity_id\": [\"T8\"], \"Route\": {\"text\": [[\"injection\"]], \"start\": [[137]], \"entity_id\": [\"T9\"]}, \"Drug\": {\"text\": [[\"ethanol\"]], \"start\": [[129]], \"entity_id\": [\"T10\"]}}}" } ] } ]
8083821_3
Zidovudine use in pregnancy: a report on 104 cases and the occurrence of birth defects.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"occurrence\"]], \"start\": [[59]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"Zidovudine\"]], \"start\": [[0]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"Zidovudine\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"birth defects\"]], \"start\": [[73]], \"entity_id\": [\"T5\"]}}" } ] } ]
2369419_1
A patient with seropositive rheumatoid arthritis developed ascites while taking weekly doses of methotrexate (MTX).
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[49]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"A patient with seropositive rheumatoid arthritis\"]], \"start\": [[0]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"ascites\"]], \"start\": [[59]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"taking weekly doses of methotrexate (MTX)\"]], \"start\": [[73]], \"entity_id\": [\"T7\"], \"Disorder\": {\"text\": [[\"seropositive rheumatoid arthritis\"]], \"start\": [[15]], \"entity_id\": [\"T8\"]}, \"Freq\": {\"text\": [[\"weekly\"]], \"start\": [[80]], \"entity_id\": [\"T9\"]}, \"Drug\": {\"text\": [[\"methotrexate\"]], \"start\": [[96]], \"entity_id\": [\"T10\"]}}}" } ] } ]
18453852_1
High incidence of adverse events in healthy volunteers receiving rifampicin and adjusted doses of lopinavir/ritonavir tablets.
true
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"receiving\"]], \"start\": [[55]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"rifampicin and adjusted doses of lopinavir/ritonavir tablets\"]], \"start\": [[65]], \"entity_id\": [\"T8\"], \"Drug\": {\"text\": [[\"rifampicin\"], [\"lopinavir\"], [\"ritonavir\"]], \"start\": [[65], [98], [108]], \"entity_id\": [\"T11\", \"T13\", \"T14\"]}, \"Route\": {\"text\": [[\"tablets\"]], \"start\": [[118]], \"entity_id\": [\"T12\"]}, \"Dosage\": {\"text\": [[\"adjusted doses\"]], \"start\": [[80]], \"entity_id\": [\"T16\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"and\"]], \"start\": [[76]], \"entity_id\": [\"T15\"]}, \"Drug\": {\"text\": [[\"rifampicin\"], [\"lopinavir\"], [\"ritonavir\"]], \"start\": [[65], [98], [108]], \"entity_id\": [\"T11\", \"T13\", \"T14\"]}}]}, \"Subject\": {\"text\": [[\"healthy volunteers\"]], \"start\": [[36]], \"entity_id\": [\"T9\"]}, \"Effect\": {\"text\": [[\"High incidence of adverse events\"]], \"start\": [[0]], \"entity_id\": [\"T10\"]}}" } ] } ]
14735388_2
We report here a case of TEN after administration of ciprofloxacin.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"administration\"]], \"start\": [[35]], \"entity_id\": [\"T6\"]}, \"Subject\": {\"text\": [[\"a case\"]], \"start\": [[15]], \"entity_id\": [\"T3\"]}, \"Effect\": {\"text\": [[\"TEN\"]], \"start\": [[25]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"ciprofloxacin\"]], \"start\": [[53]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"ciprofloxacin\"]], \"start\": [[53]], \"entity_id\": [\"T7\"]}}}" } ] } ]
20120657_3
Zidovudine induced pure red cell aplasia: a case report.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[11]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"Zidovudine\"]], \"start\": [[0]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"Zidovudine\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"pure red cell aplasia\"]], \"start\": [[19]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"a case\"]], \"start\": [[42]], \"entity_id\": [\"T7\"]}}" } ] } ]
17406804_1
A case of recall pneumonitis induced by gemcitabine is reported.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[29]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"gemcitabine\"]], \"start\": [[40]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"gemcitabine\"]], \"start\": [[40]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"recall pneumonitis\"]], \"start\": [[10]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"A case\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}}" } ] } ]
7893301_1
Albuterol-induced hypokalemia and its potential cardiac toxicity are discussed briefly.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[10]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"Albuterol\"]], \"start\": [[0]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"Albuterol\"]], \"start\": [[0]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"hypokalemia and its potential cardiac toxicity\"]], \"start\": [[18]], \"entity_id\": [\"T7\"]}}" } ] } ]
9653495_15
In the absence of an ideal dose-intense FU monotherapy regimen, monthly FU with low-dose LV provides a simple and economical means by which to achieve adequate FU efficacy in the treatment of advanced colorectal cancer.
true
[ { "events": [ { "event_id": "E1", "event_type": "Potential_therapeutic_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"treatment\"]], \"start\": [[179]], \"entity_id\": [\"T8\"]}, \"Treatment\": {\"text\": [[\"monthly FU with low-dose LV\"]], \"start\": [[64]], \"entity_id\": [\"T10\"], \"Disorder\": {\"text\": [[\"advanced colorectal cancer\"]], \"start\": [[192]], \"entity_id\": [\"T9\"]}, \"Freq\": {\"text\": [[\"monthly\"]], \"start\": [[64]], \"entity_id\": [\"T11\"]}, \"Drug\": {\"text\": [[\"FU\"], [\"LV\"]], \"start\": [[72], [89]], \"entity_id\": [\"T12\", \"T14\"]}, \"Dosage\": {\"text\": [[\"low-dose\"]], \"start\": [[80]], \"entity_id\": [\"T15\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"with\"]], \"start\": [[75]], \"entity_id\": [\"T13\"]}, \"Drug\": {\"text\": [[\"FU\"], [\"LV\"]], \"start\": [[72], [89]], \"entity_id\": [\"T12\", \"T14\"]}}]}}" } ] } ]
12503933_6
OBJECTIVE: To report a patient developing fulminant liver failure while being treated with clarithromycin for pneumonia.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"treated\"]], \"start\": [[78]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"fulminant liver failure\"]], \"start\": [[42]], \"entity_id\": [\"T3\"]}, \"Subject\": {\"text\": [[\"a patient\"]], \"start\": [[21]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"clarithromycin\"]], \"start\": [[91]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"clarithromycin\"]], \"start\": [[91]], \"entity_id\": [\"T7\"]}, \"Disorder\": {\"text\": [[\"pneumonia\"]], \"start\": [[110]], \"entity_id\": [\"T8\"]}}}" } ] } ]
6529939_3
The abnormal rhythm disappeared with the withdrawal of propranolol and when the drug was restarted a 2/1 S-A block was seen.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"seen\"]], \"start\": [[119]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"propranolol\"]], \"start\": [[55]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"propranolol\"]], \"start\": [[55]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"2/1 S-A block\"]], \"start\": [[101]], \"entity_id\": [\"T4\"]}}" } ] } ]
19826099_3
The Naranjo probability scale indicated a probable relationship between apnea and exposure to lamotrigine through breast-feeding in this infant.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"a probable relationship\"]], \"start\": [[40]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"apnea\"]], \"start\": [[72]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"lamotrigine through breast-feeding\"]], \"start\": [[94]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"lamotrigine\"]], \"start\": [[94]], \"entity_id\": [\"T8\"]}, \"Route\": {\"text\": [[\"breast-feeding\"]], \"start\": [[114]], \"entity_id\": [\"T10\"]}}, \"Subject\": {\"text\": [[\"in this infant\"]], \"start\": [[129]], \"entity_id\": [\"T6\"], \"Age\": {\"text\": [[\"infant\"]], \"start\": [[137]], \"entity_id\": [\"T7\"]}}, \"Speculated\": {\"text\": [[\"probable\"]], \"start\": [[42]], \"entity_id\": [\"T9\"], \"value\": true}}" } ] } ]
16757971_2
Listeria brain abscess, Pneumocystis pneumonia and Kaposi's sarcoma after temozolomide.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[68]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"temozolomide\"]], \"start\": [[74]], \"entity_id\": [\"T8\"], \"Drug\": {\"text\": [[\"temozolomide\"]], \"start\": [[74]], \"entity_id\": [\"T10\"]}}, \"Effect\": {\"text\": [[\"Listeria brain abscess, Pneumocystis pneumonia and Kaposi's sarcoma\"]], \"start\": [[0]], \"entity_id\": [\"T9\"]}}" } ] } ]
9920368_3
Since amiodarone was first marketed in 1992 in Japan, the incidence of amiodarone-induced thyrotoxicosis (AIT) has been increasing.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[82]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"amiodarone\"]], \"start\": [[71]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"amiodarone\"], [\"amiodarone\"]], \"start\": [[71], [6]], \"entity_id\": [\"T8\", \"T9\"]}}, \"Effect\": {\"text\": [[\"thyrotoxicosis (AIT)\"]], \"start\": [[90]], \"entity_id\": [\"T7\"]}}" } ] } ]
7619765_2
The occurrence of a myocardial infarction is reported after chemotherapy containing etoposide, in a man with no risk factors for coronary heart disease.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[54]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"chemotherapy containing etoposide\"]], \"start\": [[60]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"etoposide\"]], \"start\": [[84]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"myocardial infarction\"]], \"start\": [[20]], \"entity_id\": [\"T4\"]}, \"Subject\": {\"text\": [[\"a man with no risk factors for coronary heart disease\"]], \"start\": [[98]], \"entity_id\": [\"T5\"], \"Gender\": {\"text\": [[\"man\"]], \"start\": [[100]], \"entity_id\": [\"T7\"]}}}" } ] } ]
889156_1
The use of beclomethasone diproprionate inhaler complicated by the development of an eosinophilic pneumonia reaction.
false
[ { "events": [ { "event_id": "E2", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E2\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"development\"]], \"start\": [[67]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"beclomethasone diproprionate inhaler\"]], \"start\": [[11]], \"entity_id\": [\"T4\"], \"Route\": {\"text\": [[\"inhaler\"]], \"start\": [[40]], \"entity_id\": [\"T5\"]}, \"Drug\": {\"text\": [[\"beclomethasone diproprionate\"]], \"start\": [[11]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"eosinophilic pneumonia reaction\"]], \"start\": [[85]], \"entity_id\": [\"T6\"]}}" } ] } ]
7577414_1
Nephrotic syndrome related to systemic lupus erythematosus after griseofulvin therapy.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[59]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"griseofulvin\"]], \"start\": [[65]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"griseofulvin\"]], \"start\": [[65]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"Nephrotic syndrome related to systemic lupus erythematosus\"]], \"start\": [[0]], \"entity_id\": [\"T7\"]}}" } ] } ]
9554064_3
Theoretical basal ganglia toxicologic mechanisms of methanol poisoning are reviewed, and the role of brain imaging studies will regard to diagnosis, prognosis and impact on management is discussed.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"mechanisms\"]], \"start\": [[38]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"methanol\"]], \"start\": [[52]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"methanol\"]], \"start\": [[52]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"poisoning\"]], \"start\": [[61]], \"entity_id\": [\"T4\"]}}" } ] } ]
8485005_3
We report a case of drug-induced Kaposi's sarcoma (KS) on the sole of the right foot in a 71-year-old man, treated for 6 months with corticosteroid therapy (prednisolone 25 mg/day) for pericardial effusion.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[25]], \"entity_id\": [\"T10\"]}, \"Subject\": {\"text\": [[\"a case of\", \"a 71-year-old man\", \"for pericardial effusion\"]], \"start\": [[10, 88, 181]], \"entity_id\": [\"T9\"], \"Age\": {\"text\": [[\"71-year-old\"]], \"start\": [[90]], \"entity_id\": [\"T13\"]}, \"Gender\": {\"text\": [[\"man\"]], \"start\": [[102]], \"entity_id\": [\"T14\"]}}, \"Effect\": {\"text\": [[\"Kaposi's sarcoma (KS)\"]], \"start\": [[33]], \"entity_id\": [\"T11\"]}, \"Treatment\": {\"text\": [[\"6 months with corticosteroid therapy (prednisolone 25 mg/day)\"]], \"start\": [[119]], \"entity_id\": [\"T12\"], \"Duration\": {\"text\": [[\"6 months\"]], \"start\": [[119]], \"entity_id\": [\"T16\"]}, \"Dosage\": {\"text\": [[\"25 mg/day\"]], \"start\": [[170]], \"entity_id\": [\"T17\"]}, \"Drug\": {\"text\": [[\"prednisolone\"]], \"start\": [[157]], \"entity_id\": [\"T19\"]}, \"Disorder\": {\"text\": [[\"pericardial effusion\"]], \"start\": [[185]], \"entity_id\": [\"T20\"]}}}" } ] } ]
16196187_3
We present a case of acute epinephrine toxicity resulting in acute myocardial ischemia in a young boy with combined variable immunodeficiency syndrome who developed severe allergic reaction to intravenous immunoglobulin, and was subsequently given epinephrine by mistake intravenously rather than subcutaneously.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"toxicity\"]], \"start\": [[39]], \"entity_id\": [\"T7\"]}, \"Subject\": {\"text\": [[\"a young boy with combined variable immunodeficiency syndrome\"]], \"start\": [[90]], \"entity_id\": [\"T6\"], \"Age\": {\"text\": [[\"young\"]], \"start\": [[92]], \"entity_id\": [\"T10\"]}, \"Gender\": {\"text\": [[\"boy\"]], \"start\": [[98]], \"entity_id\": [\"T11\"]}}, \"Treatment\": {\"text\": [[\"acute epinephrine\", \"intravenous immunoglobulin, and was subsequently given epinephrine by mistake intravenously rather than subcutaneously\"]], \"start\": [[21, 193]], \"entity_id\": [\"T8\"], \"Drug\": {\"text\": [[\"epinephrine\"], [\"immunoglobulin\"]], \"start\": [[27], [205]], \"entity_id\": [\"T13\", \"T19\"]}, \"Disorder\": {\"text\": [[\"combined variable immunodeficiency syndrome\"]], \"start\": [[107]], \"entity_id\": [\"T15\"]}, \"Route\": {\"text\": [[\"intravenously\"], [\"intravenous\"]], \"start\": [[271], [193]], \"entity_id\": [\"T16\", \"T18\"]}}, \"Effect\": {\"text\": [[\"acute myocardial ischemia\", \"severe allergic reaction\"]], \"start\": [[61, 165]], \"entity_id\": [\"T9\"]}}" } ] } ]
8363533_1
Albeit rare among Western patients, such lithium-associated thyroid dysfunctions appeared to be more likely to occur in Hong Kong Chinese.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[49]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"lithium\"]], \"start\": [[41]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"lithium\"]], \"start\": [[41]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"thyroid dysfunctions\"]], \"start\": [[60]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"Hong Kong Chinese\"]], \"start\": [[120]], \"entity_id\": [\"T6\"], \"Race\": {\"text\": [[\"Hong Kong Chinese\"]], \"start\": [[120]], \"entity_id\": [\"T7\"]}}}" } ] } ]
25671244_2
Metaxalone has only recently been associated with serotonin syndrome.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[34]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"serotonin syndrome\"]], \"start\": [[50]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"Metaxalone\"]], \"start\": [[0]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"Metaxalone\"]], \"start\": [[0]], \"entity_id\": [\"T8\"]}}}" } ] } ]
19235747_1
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is reported in up to 18.6% of patients treated with intravenous bisphosphonates and can result in significant morbidity.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"related\"]], \"start\": [[15]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"osteonecrosis of the jaw (BRONJ)\"]], \"start\": [[23]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"18.6% of patients\"]], \"start\": [[77]], \"entity_id\": [\"T6\"], \"Population\": {\"text\": [[\"18.6%\"]], \"start\": [[77]], \"entity_id\": [\"T3\"]}}, \"Treatment\": {\"text\": [[\"intravenous bisphosphonates\"]], \"start\": [[108]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"Bisphosphonate\"], [\"bisphosphonates\"]], \"start\": [[0], [120]], \"entity_id\": [\"T8\", \"T10\"]}, \"Route\": {\"text\": [[\"intravenous\"]], \"start\": [[108]], \"entity_id\": [\"T9\"]}}, \"Severity\": {\"text\": [[\"significant\"]], \"start\": [[154]], \"entity_id\": [\"T11\"], \"value\": \"High\"}}" } ] } ]
8691927_3
Growth and adrenal suppression in asthmatic children treated with high-dose fluticasone propionate.
false
[ { "events": [ { "event_id": "E1", "event_type": "Potential_therapeutic_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"in\"]], \"start\": [[31]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"Growth and adrenal suppression\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Subject\": {\"text\": [[\"asthmatic children\"]], \"start\": [[34]], \"entity_id\": [\"T4\"], \"Age\": {\"text\": [[\"children\"]], \"start\": [[44]], \"entity_id\": [\"T8\"]}}, \"Treatment\": {\"text\": [[\"high-dose fluticasone propionate\"]], \"start\": [[66]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"fluticasone propionate\"]], \"start\": [[76]], \"entity_id\": [\"T9\"]}, \"Dosage\": {\"text\": [[\"high-dose\"]], \"start\": [[66]], \"entity_id\": [\"T10\"]}, \"Disorder\": {\"text\": [[\"asthmatic\"]], \"start\": [[34]], \"entity_id\": [\"T11\"]}}}" } ] } ]
14674674_1
A diagnosis of infliximab-induced lupus was made and the drug treatment was withdrawn.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[26]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"infliximab\"]], \"start\": [[15]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"infliximab\"]], \"start\": [[15]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"lupus\"]], \"start\": [[34]], \"entity_id\": [\"T5\"]}}" } ] } ]
10510156_2
AIMS: To identify the human cytochrome P450 enzyme (s) involved in the in vitro metabolism of rosiglitazone, a potential oral antidiabetic agent for the treatment of type 2 diabetes-mellitus.
false
[ { "events": [ { "event_id": "E1", "event_type": "Potential_therapeutic_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"potential oral\"]], \"start\": [[112]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"rosiglitazone\"]], \"start\": [[95]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"rosiglitazone\"]], \"start\": [[95]], \"entity_id\": [\"T10\"]}, \"Disorder\": {\"text\": [[\"type 2 diabetes-mellitus.\"]], \"start\": [[167]], \"entity_id\": [\"T11\"]}, \"Route\": {\"text\": [[\"oral\"]], \"start\": [[122]], \"entity_id\": [\"T12\"]}}}" } ] } ]
2011096_5
Neurotoxicity can occur at any time using high-dose cytosine therapy.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"occur\"]], \"start\": [[18]], \"entity_id\": [\"T7\"]}, \"Effect\": {\"text\": [[\"Neurotoxicity\"]], \"start\": [[0]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"high-dose cytosine\"]], \"start\": [[42]], \"entity_id\": [\"T6\"], \"Dosage\": {\"text\": [[\"high-dose\"]], \"start\": [[42]], \"entity_id\": [\"T9\"]}, \"Drug\": {\"text\": [[\"cytosine\"]], \"start\": [[52]], \"entity_id\": [\"T10\"]}}}" } ] } ]
3677571_15
The possibility of phenytoin hypersensitivity reactions should be considered when patients receiving phenytoin have unusual symptoms, particularly fever, rash, and lymphadenopathy.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"receiving\"]], \"start\": [[91]], \"entity_id\": [\"T11\"]}, \"Effect\": {\"text\": [[\"phenytoin hypersensitivity\", \"fever, rash, and lymphadenopathy\"]], \"start\": [[19, 147]], \"entity_id\": [\"T10\"]}, \"Treatment\": {\"text\": [[\"phenytoin\"]], \"start\": [[101]], \"entity_id\": [\"T12\"], \"Drug\": {\"text\": [[\"phenytoin\"]], \"start\": [[101]], \"entity_id\": [\"T14\"]}}, \"Speculated\": {\"text\": [[\"possibility\"]], \"start\": [[4]], \"entity_id\": [\"T13\"], \"value\": true}}" } ] } ]
9360190_2
Magnesium tocolysis as the cause of urinary calculus during pregnancy.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"cause\"]], \"start\": [[27]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"Magnesium tocolysis\"]], \"start\": [[0]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"Magnesium\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"urinary calculus during pregnancy\"]], \"start\": [[36]], \"entity_id\": [\"T5\"]}}" } ] } ]
14601701_1
Ocular ethambutol toxicity.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"toxicity\"]], \"start\": [[18]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"toxicity\"]], \"start\": [[18]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"Ocular ethambutol\"]], \"start\": [[0]], \"entity_id\": [\"T4\"], \"Route\": {\"text\": [[\"Ocular\"]], \"start\": [[0]], \"entity_id\": [\"T7\"]}, \"Drug\": {\"text\": [[\"ethambutol\"]], \"start\": [[7]], \"entity_id\": [\"T8\"]}}}" } ] } ]
8891729_1
Fatal intravascular autoimmune hemolytic anemia after fludarabine treatment for chronic lymphocytic leukemia.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[48]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Fatal intravascular autoimmune hemolytic anemia\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"fludarabine treatment\"]], \"start\": [[54]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"fludarabine\"]], \"start\": [[54]], \"entity_id\": [\"T7\"]}, \"Disorder\": {\"text\": [[\"chronic lymphocytic leukemia\"]], \"start\": [[80]], \"entity_id\": [\"T8\"]}}, \"Severity\": {\"text\": [[\"Fatal\"]], \"start\": [[0]], \"entity_id\": [\"T9\"], \"value\": \"High\"}}" } ] } ]
14557583_1
A 74-year-old patient with idiopathic Parkinson's disease was evaluated for unintended sleep episodes that occurred after long-term treatment with 400 mg/day of L-dopa.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[116]], \"entity_id\": [\"T6\"]}, \"Subject\": {\"text\": [[\"A 74-year-old patient with idiopathic Parkinson's disease\"]], \"start\": [[0]], \"entity_id\": [\"T3\"], \"Age\": {\"text\": [[\"74-year-old\"]], \"start\": [[2]], \"entity_id\": [\"T7\"]}}, \"Treatment\": {\"text\": [[\"long-term treatment with 400 mg/day of L-dopa\"]], \"start\": [[122]], \"entity_id\": [\"T4\"], \"Disorder\": {\"text\": [[\"idiopathic Parkinson's disease\"]], \"start\": [[27]], \"entity_id\": [\"T8\"]}, \"Dosage\": {\"text\": [[\"400 mg/day\"]], \"start\": [[147]], \"entity_id\": [\"T9\"]}, \"Drug\": {\"text\": [[\"L-dopa\"]], \"start\": [[161]], \"entity_id\": [\"T10\"]}, \"Duration\": {\"text\": [[\"long-term treatment\"]], \"start\": [[122]], \"entity_id\": [\"T11\"]}}, \"Effect\": {\"text\": [[\"unintended sleep episodes\"]], \"start\": [[76]], \"entity_id\": [\"T5\"]}}" } ] } ]
6683487_2
Thrombotic thrombocytopenic purpura (TTP) developed in a patient with seropositive rheumatoid arthritis (RA) after 2 1/2 months of treatment with penicillamine.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[42]], \"entity_id\": [\"T10\"]}, \"Effect\": {\"text\": [[\"Thrombotic thrombocytopenic purpura (TTP)\"]], \"start\": [[0]], \"entity_id\": [\"T9\"]}, \"Subject\": {\"text\": [[\"a patient with seropositive rheumatoid arthritis (RA)\"]], \"start\": [[55]], \"entity_id\": [\"T11\"]}, \"Treatment\": {\"text\": [[\"2 1/2 months of treatment with penicillamine\"]], \"start\": [[115]], \"entity_id\": [\"T12\"], \"Disorder\": {\"text\": [[\"rheumatoid arthritis\"]], \"start\": [[83]], \"entity_id\": [\"T13\"]}, \"Drug\": {\"text\": [[\"penicillamine\"]], \"start\": [[146]], \"entity_id\": [\"T14\"]}, \"Duration\": {\"text\": [[\"2 1/2 months\"]], \"start\": [[115]], \"entity_id\": [\"T1\"]}}}" } ] } ]
9337441_1
Phenolphthalein-induced toxic epidermal necrolysis.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[16]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"Phenolphthalein\"]], \"start\": [[0]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"Phenolphthalein\"]], \"start\": [[0]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"toxic epidermal necrolysis\"]], \"start\": [[24]], \"entity_id\": [\"T6\"]}}" } ] } ]
1536494_2
We present a case of ethylenediamine-induced delayed hypersensitivity reaction in a 46-year-old woman who received parenteral aminophylline for an acute asthma exacerbation.
true
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[37]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"ethylenediamine\"]], \"start\": [[21]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"ethylenediamine\"]], \"start\": [[21]], \"entity_id\": [\"T11\"]}}, \"Effect\": {\"text\": [[\"delayed hypersensitivity reaction\"]], \"start\": [[45]], \"entity_id\": [\"T6\"]}, \"Subject\": {\"text\": [[\"a 46-year-old woman\"]], \"start\": [[82]], \"entity_id\": [\"T7\"], \"Age\": {\"text\": [[\"46-year-old\"]], \"start\": [[84]], \"entity_id\": [\"T9\"]}, \"Gender\": {\"text\": [[\"woman\"]], \"start\": [[96]], \"entity_id\": [\"T10\"]}}}" }, { "event_id": "E2", "event_type": "Potential_therapeutic_event", "event_data": "{\"event_id\": \"E2\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"received\"]], \"start\": [[106]], \"entity_id\": [\"T13\"]}, \"Subject\": {\"text\": [[\"a 46-year-old woman\"]], \"start\": [[82]], \"entity_id\": [\"T7\"], \"Age\": {\"text\": [[\"46-year-old\"]], \"start\": [[84]], \"entity_id\": [\"T9\"]}, \"Gender\": {\"text\": [[\"woman\"]], \"start\": [[96]], \"entity_id\": [\"T10\"]}}, \"Treatment\": {\"text\": [[\"parenteral aminophylline\"]], \"start\": [[115]], \"entity_id\": [\"T14\"], \"Disorder\": {\"text\": [[\"acute asthma exacerbation\"]], \"start\": [[147]], \"entity_id\": [\"T8\"]}, \"Route\": {\"text\": [[\"parenteral\"]], \"start\": [[115]], \"entity_id\": [\"T15\"]}, \"Drug\": {\"text\": [[\"aminophylline\"]], \"start\": [[126]], \"entity_id\": [\"T16\"]}}}" } ] } ]
8730143_2
Physicians should be aware of the potentially lethal side effects of dapsone.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"of\"]], \"start\": [[66]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"dapsone\"]], \"start\": [[69]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"dapsone\"]], \"start\": [[69]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"lethal side effects\"]], \"start\": [[46]], \"entity_id\": [\"T5\"]}, \"Speculated\": {\"text\": [[\"potentially\"]], \"start\": [[34]], \"entity_id\": [\"T6\"], \"value\": true}, \"Severity\": {\"text\": [[\"lethal\"]], \"start\": [[46]], \"entity_id\": [\"T7\"], \"value\": \"High\"}}" } ] } ]
3753891_1
Acute myocardial necrosis during administration of amsacrine.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"during\"]], \"start\": [[26]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Acute myocardial necrosis\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"amsacrine\"]], \"start\": [[51]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"amsacrine\"]], \"start\": [[51]], \"entity_id\": [\"T6\"]}}}" } ] } ]
12699871_2
Rapid identification of speech loss linked to FK506 may be important because reduction or cessation of the drug may be associated with reverse of speech loss.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"linked\"]], \"start\": [[36]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"speech loss\"]], \"start\": [[24]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"FK506\"]], \"start\": [[46]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"FK506\"]], \"start\": [[46]], \"entity_id\": [\"T7\"]}}}" } ] } ]
667809_2
Fatal pulmonary fibrosis following 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapy.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"following\"]], \"start\": [[25]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"pulmonary fibrosis\"]], \"start\": [[6]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapy\"]], \"start\": [[35]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)\"]], \"start\": [[35]], \"entity_id\": [\"T7\"]}}, \"Severity\": {\"text\": [[\"Fatal\"]], \"start\": [[0]], \"entity_id\": [\"T8\"], \"value\": \"High\"}}" } ] } ]
8862924_4
The increasing prevalence of methamphetamine abuse and the severity of the associated ulcers should alert ophthalmologists to the problem of methamphetamine-related keratitis.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"related\"]], \"start\": [[157]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"associated ulcers\", \"keratitis\"]], \"start\": [[75, 165]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"methamphetamine abuse\", \"methamphetamine\"]], \"start\": [[29, 141]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"methamphetamine\"], [\"methamphetamine\"]], \"start\": [[29], [141]], \"entity_id\": [\"T9\", \"T10\"]}}, \"Severity\": {\"text\": [[\"severity\"]], \"start\": [[59]], \"entity_id\": [\"T8\"], \"value\": \"Medium\"}}" } ] } ]
15735923_5
MDS was diagnosed 8.4 months after beginning TMZ.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"diagnosed\"]], \"start\": [[8]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"MDS\"]], \"start\": [[0]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"8.4 months after beginning TMZ\"]], \"start\": [[18]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"TMZ\"]], \"start\": [[45]], \"entity_id\": [\"T7\"]}, \"Time_elapsed\": {\"text\": [[\"8.4 months\"]], \"start\": [[18]], \"entity_id\": [\"T8\"]}}}" } ] } ]
8979664_3
Uveitis associated with rifabutin therapy: a clinical alert.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[8]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Uveitis\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"rifabutin therapy\"]], \"start\": [[24]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"rifabutin\"]], \"start\": [[24]], \"entity_id\": [\"T6\"]}}}" } ] } ]
18698687_3
We report a case of a patient with ciprofloxacin-induced SJS and acute onset of VBDS, and reviewed the related literature.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[49]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"ciprofloxacin\"]], \"start\": [[35]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"ciprofloxacin\"]], \"start\": [[35]], \"entity_id\": [\"T10\"]}}, \"Effect\": {\"text\": [[\"SJS\"], [\"acute onset of VBDS\"]], \"start\": [[57], [65]], \"entity_id\": [\"T7\", \"T8\"]}, \"Subject\": {\"text\": [[\"a patient\"]], \"start\": [[20]], \"entity_id\": [\"T9\"]}}" } ] } ]
8880251_3
This case supports the assessment that MH and diabetes are associated diseases and that cresol could possibly trigger MH.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"trigger\"]], \"start\": [[110]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"cresol\"]], \"start\": [[88]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"cresol\"]], \"start\": [[88]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"MH\"]], \"start\": [[118]], \"entity_id\": [\"T4\"]}, \"Speculated\": {\"text\": [[\"possibly\"]], \"start\": [[101]], \"entity_id\": [\"T7\"], \"value\": true}}" } ] } ]
12150593_1
Neonatal mydriasis: intravenous lidocaine adverse reaction.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"adverse reaction\"]], \"start\": [[42]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"Neonatal mydriasis\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"lidocaine\"]], \"start\": [[32]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"lidocaine\"]], \"start\": [[32]], \"entity_id\": [\"T6\"]}}, \"Subject\": {\"text\": [[\"Neonatal\"]], \"start\": [[0]], \"entity_id\": [\"T7\"], \"Age\": {\"text\": [[\"Neonatal\"]], \"start\": [[0]], \"entity_id\": [\"T8\"]}}}" } ] } ]
3417739_1
Acute renal failure in a patient treated by continuous povidone-iodine mediastinal irrigation.
true
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"in\"]], \"start\": [[20]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Acute renal failure\"]], \"start\": [[0]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"a patient\"]], \"start\": [[23]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"continuous povidone-iodine mediastinal irrigation\"]], \"start\": [[44]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"povidone\"], [\"iodine\"]], \"start\": [[55], [64]], \"entity_id\": [\"T8\", \"T9\"]}, \"Route\": {\"text\": [[\"irrigation\"]], \"start\": [[83]], \"entity_id\": [\"T10\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"-\"]], \"start\": [[63]], \"entity_id\": [\"T11\"]}, \"Drug\": {\"text\": [[\"povidone\"], [\"iodine\"]], \"start\": [[55], [64]], \"entity_id\": [\"T8\", \"T9\"]}}]}}" } ] } ]
7577414_2
To our knowledge, this is the first case of griseofulvin-exacerbated lupus in which nephrotic syndrome has been observed.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"exacerbated\"]], \"start\": [[57]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"griseofulvin\"]], \"start\": [[44]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"griseofulvin\"]], \"start\": [[44]], \"entity_id\": [\"T9\"]}}, \"Effect\": {\"text\": [[\"lupus\", \"nephrotic syndrome\"]], \"start\": [[69, 84]], \"entity_id\": [\"T7\"]}, \"Subject\": {\"text\": [[\"the first case\"]], \"start\": [[26]], \"entity_id\": [\"T10\"]}, \"Speculated\": {\"text\": [[\"To our knowledge\"]], \"start\": [[0]], \"entity_id\": [\"T8\"], \"value\": true}}" } ] } ]
12630660_6
After reviewing the literature we suggest the CPM was a complication of lithium toxicity which affected the lateral geniculate nucleus which produced blindness.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"complication\"]], \"start\": [[56]], \"entity_id\": [\"T9\"]}, \"Effect\": {\"text\": [[\"CPM\", \"lithium toxicity\", \"blindness\"]], \"start\": [[46, 72, 150]], \"entity_id\": [\"T8\"]}, \"Treatment\": {\"text\": [[\"lithium\"]], \"start\": [[72]], \"entity_id\": [\"T10\"], \"Drug\": {\"text\": [[\"lithium\"]], \"start\": [[72]], \"entity_id\": [\"T11\"]}}, \"Speculated\": {\"text\": [[\"suggest\"]], \"start\": [[34]], \"entity_id\": [\"T7\"], \"value\": true}}" } ] } ]
1267457_1
A 71-year-old man, who had a history of a previous bullous drug reaction to a sulfonamide, began receiving an ophthalmic preparation that contained sulfacetamide sodium.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"reaction\"]], \"start\": [[64]], \"entity_id\": [\"T6\"]}, \"Subject\": {\"text\": [[\"A 71-year-old man\"]], \"start\": [[0]], \"entity_id\": [\"T3\"], \"Age\": {\"text\": [[\"71-year-old\"]], \"start\": [[2]], \"entity_id\": [\"T7\"]}, \"Gender\": {\"text\": [[\"man\"]], \"start\": [[14]], \"entity_id\": [\"T8\"]}}, \"Treatment\": {\"text\": [[\"sulfonamide\"]], \"start\": [[78]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"sulfonamide\"], [\"sulfacetamide sodium\"]], \"start\": [[78], [148]], \"entity_id\": [\"T9\", \"T10\"]}}, \"Effect\": {\"text\": [[\"bullous\"]], \"start\": [[51]], \"entity_id\": [\"T5\"]}}" } ] } ]
9022114_4
The authors report on two patients with corneal ulcers refractory to conventional treatment while the patients were undergoing oral colchicine therapy.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"undergoing\"]], \"start\": [[116]], \"entity_id\": [\"T4\"]}, \"Subject\": {\"text\": [[\"two patients\"]], \"start\": [[22]], \"entity_id\": [\"T3\"], \"Population\": {\"text\": [[\"two\"]], \"start\": [[22]], \"entity_id\": [\"T7\"]}}, \"Treatment\": {\"text\": [[\"oral colchicine therapy\"]], \"start\": [[127]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"colchicine\"]], \"start\": [[132]], \"entity_id\": [\"T8\"]}, \"Route\": {\"text\": [[\"oral\"]], \"start\": [[127]], \"entity_id\": [\"T9\"]}}, \"Effect\": {\"text\": [[\"corneal ulcers\"]], \"start\": [[40]], \"entity_id\": [\"T6\"]}}" } ] } ]
2937155_3
Vancomycin-induced vasculitis.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[11]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"Vancomycin\"]], \"start\": [[0]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"Vancomycin\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"vasculitis\"]], \"start\": [[19]], \"entity_id\": [\"T5\"]}}" } ] } ]
8641617_2
Based on our findings, it is thus concluded that cisplatin may cause C. difficile colitis.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"cause\"]], \"start\": [[63]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"cisplatin\"]], \"start\": [[49]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"cisplatin\"]], \"start\": [[49]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"C. difficile colitis\"]], \"start\": [[69]], \"entity_id\": [\"T5\"]}, \"Speculated\": {\"text\": [[\"may\"]], \"start\": [[59]], \"entity_id\": [\"T6\"], \"value\": true}}" } ] } ]
7249424_2
Nephrotic syndrome associated with lithium therapy.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[19]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Nephrotic syndrome\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"lithium therapy\"]], \"start\": [[35]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"lithium\"]], \"start\": [[35]], \"entity_id\": [\"T6\"]}}}" } ] } ]
10728450_1
We report 2 patients who developed polyarteritis nodosa following vaccination against hepatitis B.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[25]], \"entity_id\": [\"T4\"]}, \"Subject\": {\"text\": [[\"2 patients\"]], \"start\": [[10]], \"entity_id\": [\"T3\"], \"Population\": {\"text\": [[\"2\"]], \"start\": [[10]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"polyarteritis nodosa\"]], \"start\": [[35]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"vaccination against hepatitis B\"]], \"start\": [[66]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"vaccination against hepatitis B\"]], \"start\": [[66]], \"entity_id\": [\"T8\"]}}}" } ] } ]
7594371_3
We recommend the cautious use of ketorolac in patients with underlying illnesses where NSAID-induced ototoxicity could result in adverse otologic consequences.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"where\"]], \"start\": [[81]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"ketorolac\"]], \"start\": [[33]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"ketorolac\"]], \"start\": [[33]], \"entity_id\": [\"T9\"]}}, \"Subject\": {\"text\": [[\"patients with underlying illnesses\"]], \"start\": [[46]], \"entity_id\": [\"T4\"], \"Disorder\": {\"text\": [[\"underlying illnesses\"]], \"start\": [[60]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"NSAID-induced ototoxicity could result in adverse otologic consequences\"]], \"start\": [[87]], \"entity_id\": [\"T5\"]}, \"Speculated\": {\"text\": [[\"could\"]], \"start\": [[113]], \"entity_id\": [\"T8\"], \"value\": true}}" } ] } ]
19660974_1
Colitis as a manifestation of infliximab-associated disseminated cryptococcosis.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[41]], \"entity_id\": [\"T8\"]}, \"Effect\": {\"text\": [[\"Colitis\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"infliximab\"]], \"start\": [[30]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"infliximab\"]], \"start\": [[30]], \"entity_id\": [\"T9\"]}}}" } ] } ]
8276031_2
A 15-month-old girl with rhinopharyngitis was treated with a nasal solution containing the imidazoline derivative naphazoline.
false
[ { "events": [ { "event_id": "E1", "event_type": "Potential_therapeutic_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"treated\"]], \"start\": [[46]], \"entity_id\": [\"T7\"]}, \"Subject\": {\"text\": [[\"A 15-month-old girl with rhinopharyngitis\"]], \"start\": [[0]], \"entity_id\": [\"T6\"], \"Age\": {\"text\": [[\"15-month-old\"]], \"start\": [[2]], \"entity_id\": [\"T9\"]}, \"Gender\": {\"text\": [[\"girl\"]], \"start\": [[15]], \"entity_id\": [\"T10\"]}}, \"Treatment\": {\"text\": [[\"a nasal solution containing the imidazoline derivative naphazoline\"]], \"start\": [[59]], \"entity_id\": [\"T8\"], \"Disorder\": {\"text\": [[\"rhinopharyngitis\"]], \"start\": [[25]], \"entity_id\": [\"T11\"]}, \"Drug\": {\"text\": [[\"imidazoline derivative\"]], \"start\": [[91]], \"entity_id\": [\"T12\"]}, \"Route\": {\"text\": [[\"naphazoline\"]], \"start\": [[114]], \"entity_id\": [\"T13\"]}}}" } ] } ]
9804082_1
Three diabetic cases of acute dizziness due to initial administration of voglibose.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"due\"]], \"start\": [[40]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"Three diabetic cases\"]], \"start\": [[0]], \"entity_id\": [\"T3\"], \"Population\": {\"text\": [[\"Three\"]], \"start\": [[0]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"acute dizziness\"]], \"start\": [[24]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"initial administration of voglibose\"]], \"start\": [[47]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"voglibose\"]], \"start\": [[73]], \"entity_id\": [\"T9\"]}, \"Disorder\": {\"text\": [[\"diabetic\"]], \"start\": [[6]], \"entity_id\": [\"T10\"]}}}" } ] } ]
14607011_1
Fatal cold medication intoxication in an infant.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"in\"]], \"start\": [[35]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"Fatal cold medication intoxication\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"cold medication\"]], \"start\": [[6]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"cold medication\"]], \"start\": [[6]], \"entity_id\": [\"T11\"]}}, \"Subject\": {\"text\": [[\"infant\"]], \"start\": [[41]], \"entity_id\": [\"T8\"], \"Age\": {\"text\": [[\"infant\"]], \"start\": [[41]], \"entity_id\": [\"T9\"]}}}" } ] } ]
7779233_1
Case study: a modified topical treatment regimen for sodium warfarin-induced necrotizing fasciitis.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[69]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"sodium warfarin\"]], \"start\": [[53]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"sodium warfarin\"]], \"start\": [[53]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"necrotizing fasciitis\"]], \"start\": [[77]], \"entity_id\": [\"T5\"]}}" } ] } ]
16211208_2
Marked QT prolongation and torsades de pointes secondary to acute ischemia in an elderly man taking dofetilide for atrial fibrillation: a cautionary tale.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"taking\"]], \"start\": [[93]], \"entity_id\": [\"T10\"]}, \"Treatment\": {\"text\": [[\"dofetilide\"]], \"start\": [[100]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"dofetilide\"]], \"start\": [[100]], \"entity_id\": [\"T14\"]}, \"Disorder\": {\"text\": [[\"atrial fibrillation\"]], \"start\": [[115]], \"entity_id\": [\"T15\"]}}, \"Subject\": {\"text\": [[\"an elderly man\"]], \"start\": [[78]], \"entity_id\": [\"T8\"], \"Age\": {\"text\": [[\"elderly\"]], \"start\": [[81]], \"entity_id\": [\"T11\"]}, \"Gender\": {\"text\": [[\"man\"]], \"start\": [[89]], \"entity_id\": [\"T12\"]}}, \"Effect\": {\"text\": [[\"Marked QT prolongation and torsades de pointes secondary to acute ischemia\"]], \"start\": [[0]], \"entity_id\": [\"T9\"]}}" } ] } ]
18431096_1
Methylphenidate and dextroamphetamine-induced peripheral vasculopathy.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[38]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"Methylphenidate and dextroamphetamine\"]], \"start\": [[0]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"dextroamphetamine\"], [\"Methylphenidate\"]], \"start\": [[20], [0]], \"entity_id\": [\"T7\", \"T8\"]}}, \"Effect\": {\"text\": [[\"peripheral vasculopathy\"]], \"start\": [[46]], \"entity_id\": [\"T6\"]}}" } ] } ]
8969033_3
The reversal of heparin by protamine may cause severe hemodynamic deterioration, characterized by systemic hypotension, pulmonary hypertension, and bronchoconstriction.
true
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"cause\"]], \"start\": [[41]], \"entity_id\": [\"T10\"]}, \"Effect\": {\"text\": [[\"severe hemodynamic deterioration\", \"systemic hypotension, pulmonary hypertension, and bronchoconstriction\"]], \"start\": [[47, 98]], \"entity_id\": [\"T9\"]}, \"Treatment\": {\"text\": [[\"The reversal of heparin by protamine\"]], \"start\": [[0]], \"entity_id\": [\"T12\"], \"Drug\": {\"text\": [[\"heparin\"], [\"protamine\"]], \"start\": [[16], [27]], \"entity_id\": [\"T16\", \"T17\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"reversal\"]], \"start\": [[4]], \"entity_id\": [\"T15\"]}, \"Drug\": {\"text\": [[\"heparin\"], [\"protamine\"]], \"start\": [[16], [27]], \"entity_id\": [\"T16\", \"T17\"]}}]}, \"Speculated\": {\"text\": [[\"may\"]], \"start\": [[37]], \"entity_id\": [\"T11\"], \"value\": true}}" } ] } ]
19826099_1
OBJECTIVE: To report a case of severe apnea in an infant exposed to lamotrigine through breast-feeding.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"in\"]], \"start\": [[44]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"severe apnea\"]], \"start\": [[31]], \"entity_id\": [\"T3\"]}, \"Subject\": {\"text\": [[\"an infant\"]], \"start\": [[47]], \"entity_id\": [\"T4\"], \"Age\": {\"text\": [[\"infant\"]], \"start\": [[50]], \"entity_id\": [\"T7\"]}}, \"Treatment\": {\"text\": [[\"exposed to lamotrigine through breast-feeding\"]], \"start\": [[57]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"lamotrigine\"]], \"start\": [[68]], \"entity_id\": [\"T8\"]}, \"Route\": {\"text\": [[\"breast-feeding\"]], \"start\": [[88]], \"entity_id\": [\"T9\"]}}, \"Severity\": {\"text\": [[\"severe\"]], \"start\": [[31]], \"entity_id\": [\"T10\"], \"value\": \"Medium\"}}" } ] } ]
1316047_1
Hemodynamic collapse following labetalol administration in preeclampsia.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"following\"]], \"start\": [[21]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"Hemodynamic collapse\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"labetalol\"]], \"start\": [[31]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"labetalol\"]], \"start\": [[31]], \"entity_id\": [\"T7\"]}, \"Disorder\": {\"text\": [[\"preeclampsia\"]], \"start\": [[59]], \"entity_id\": [\"T8\"]}}}" } ] } ]
18801826_3
We report a case of a 35-year old female who developed new onset type II diabetes mellitus with hyperosmolar hyperglycaemic coma and acute renal failure following treatment with a SGA for a first manic episode.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[45]], \"entity_id\": [\"T10\"]}, \"Subject\": {\"text\": [[\"35-year old female\"]], \"start\": [[22]], \"entity_id\": [\"T9\"], \"Age\": {\"text\": [[\"35-year old\"]], \"start\": [[22]], \"entity_id\": [\"T13\"]}, \"Gender\": {\"text\": [[\"female\"]], \"start\": [[34]], \"entity_id\": [\"T14\"]}}, \"Effect\": {\"text\": [[\"type II diabetes mellitus with hyperosmolar hyperglycaemic coma and acute renal failure\"]], \"start\": [[65]], \"entity_id\": [\"T11\"]}, \"Treatment\": {\"text\": [[\"treatment with a SGA\"]], \"start\": [[163]], \"entity_id\": [\"T12\"], \"Drug\": {\"text\": [[\"SGA\"]], \"start\": [[180]], \"entity_id\": [\"T15\"]}}}" } ] } ]
8503421_3
We report the occurrence of renal failure due to cholesterol crystal embolization following thrombolytic therapy with intravenous recombinant tissue-type plasminogen activator (t-PA).
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"occurrence\"]], \"start\": [[14]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"thrombolytic therapy with intravenous recombinant tissue-type plasminogen activator (t-PA)\"]], \"start\": [[92]], \"entity_id\": [\"T9\"], \"Route\": {\"text\": [[\"intravenous\"]], \"start\": [[118]], \"entity_id\": [\"T10\"]}, \"Drug\": {\"text\": [[\"recombinant tissue-type plasminogen activator\"]], \"start\": [[130]], \"entity_id\": [\"T11\"]}}, \"Effect\": {\"text\": [[\"renal failure due to cholesterol crystal embolization\"]], \"start\": [[28]], \"entity_id\": [\"T8\"]}}" } ] } ]
9161656_8
The asthma resolved within 24 hours following three albuterol inhalations.
false
[ { "events": [ { "event_id": "E1", "event_type": "Potential_therapeutic_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"resolved\"]], \"start\": [[11]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"three albuterol inhalations\"]], \"start\": [[46]], \"entity_id\": [\"T6\"], \"Disorder\": {\"text\": [[\"asthma\"]], \"start\": [[4]], \"entity_id\": [\"T7\"]}, \"Dosage\": {\"text\": [[\"three\"]], \"start\": [[46]], \"entity_id\": [\"T8\"]}, \"Drug\": {\"text\": [[\"albuterol\"]], \"start\": [[52]], \"entity_id\": [\"T9\"]}, \"Time_elapsed\": {\"text\": [[\"within 24 hours\"]], \"start\": [[20]], \"entity_id\": [\"T10\"]}, \"Route\": {\"text\": [[\"inhalations\"]], \"start\": [[62]], \"entity_id\": [\"T4\"]}}}" } ] } ]
2875665_2
Administration of amantadine was associated with psychotic decompensations in two schizophrenic patients being maintained on concomitant neuroleptic medication.
true
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[33]], \"entity_id\": [\"T10\"]}, \"Treatment\": {\"text\": [[\"concomitant neuroleptic medication\", \"amantadine\"]], \"start\": [[125, 18]], \"entity_id\": [\"T9\"], \"Drug\": {\"text\": [[\"amantadine\"], [\"neuroleptic\"]], \"start\": [[18], [137]], \"entity_id\": [\"T15\", \"T16\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"concomitant\"]], \"start\": [[125]], \"entity_id\": [\"T17\"]}, \"Drug\": {\"text\": [[\"neuroleptic\"], [\"amantadine\"]], \"start\": [[137], [18]], \"entity_id\": [\"T16\", \"T15\"]}}]}, \"Effect\": {\"text\": [[\"psychotic decompensations\"]], \"start\": [[49]], \"entity_id\": [\"T11\"]}, \"Subject\": {\"text\": [[\"two schizophrenic patients\"]], \"start\": [[78]], \"entity_id\": [\"T12\"], \"Population\": {\"text\": [[\"two\"]], \"start\": [[78]], \"entity_id\": [\"T13\"]}, \"Disorder\": {\"text\": [[\"schizophrenic\"]], \"start\": [[82]], \"entity_id\": [\"T14\"]}}}" } ] } ]
6998294_1
Clinicians should be aware of fasting hypoglycemia as an unusual but potentially serious complication of disopyramide therapy.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"complication\"]], \"start\": [[89]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"disopyramide\"]], \"start\": [[105]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"disopyramide\"]], \"start\": [[105]], \"entity_id\": [\"T9\"]}}, \"Effect\": {\"text\": [[\"fasting hypoglycemia\"]], \"start\": [[30]], \"entity_id\": [\"T4\"]}, \"Speculated\": {\"text\": [[\"potentially\"]], \"start\": [[69]], \"entity_id\": [\"T7\"], \"value\": true}}" } ] } ]
1569260_1
To the best of our knowledge, this is the first reported patient with captopril-induced pemphigus in whom no new lesions developed after subsequent treatment with enalapril.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[80]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"captopril\"]], \"start\": [[70]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"captopril\"]], \"start\": [[70]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"pemphigus\"]], \"start\": [[88]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"patient\"]], \"start\": [[57]], \"entity_id\": [\"T6\"]}}" } ] } ]
9494448_5
Fortunately, a hypersensitivity reaction to one formulation of cyclosporine does not preclude use of a different formulation.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"to\"]], \"start\": [[41]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"hypersensitivity reaction\"]], \"start\": [[15]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"one formulation of cyclosporine\"]], \"start\": [[44]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"cyclosporine\"]], \"start\": [[63]], \"entity_id\": [\"T6\"]}}}" } ] } ]
11302479_1
She developed a severe urticarial rash 3 weeks following initiation of therapy with Enoxaparin.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[4]], \"entity_id\": [\"T3\"]}, \"Effect\": {\"text\": [[\"urticarial rash\"]], \"start\": [[23]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"Enoxaparin\"]], \"start\": [[84]], \"entity_id\": [\"T5\"], \"Time_elapsed\": {\"text\": [[\"3 weeks following\"]], \"start\": [[39]], \"entity_id\": [\"T6\"]}, \"Drug\": {\"text\": [[\"Enoxaparin\"]], \"start\": [[84]], \"entity_id\": [\"T7\"]}}, \"Severity\": {\"text\": [[\"severe\"]], \"start\": [[16]], \"entity_id\": [\"T8\"], \"value\": \"High\"}}" } ] } ]
9545161_3
Fatal toxic epidermal necrolysis related to lamotrigine administration.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"related to\"]], \"start\": [[33]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Fatal toxic epidermal necrolysis\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"lamotrigine administration\"]], \"start\": [[44]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"lamotrigine\"]], \"start\": [[44]], \"entity_id\": [\"T7\"]}}, \"Severity\": {\"text\": [[\"Fatal\"]], \"start\": [[0]], \"entity_id\": [\"T6\"], \"value\": \"Medium\"}}" } ] } ]
11918514_3
OBJECTIVE: To document a case of serotonin syndrome (SS) associated with mirtazapine monotherapy, review the previously reported cases of SS associated with this tetracyclic antidepressant, and discuss the possible pathogenic mechanisms leading to this serious adverse drug reaction.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[57]], \"entity_id\": [\"T7\"]}, \"Subject\": {\"text\": [[\"a case\"]], \"start\": [[23]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"serotonin syndrome (SS)\"]], \"start\": [[33]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"mirtazapine monotherapy\"]], \"start\": [[73]], \"entity_id\": [\"T8\"], \"Drug\": {\"text\": [[\"mirtazapine\"]], \"start\": [[73]], \"entity_id\": [\"T9\"]}}}" } ] } ]
15331204_6
CONCLUSION: Therapy with indapamide may induce diabetes in essential hypertension patients.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induce\"]], \"start\": [[40]], \"entity_id\": [\"T10\"]}, \"Effect\": {\"text\": [[\"diabetes\"]], \"start\": [[47]], \"entity_id\": [\"T8\"]}, \"Treatment\": {\"text\": [[\"indapamide\"]], \"start\": [[25]], \"entity_id\": [\"T9\"], \"Drug\": {\"text\": [[\"indapamide\"]], \"start\": [[25]], \"entity_id\": [\"T14\"]}, \"Disorder\": {\"text\": [[\"essential hypertension\"]], \"start\": [[59]], \"entity_id\": [\"T15\"]}}, \"Subject\": {\"text\": [[\"essential hypertension patients\"]], \"start\": [[59]], \"entity_id\": [\"T11\"]}, \"Speculated\": {\"text\": [[\"may\"]], \"start\": [[36]], \"entity_id\": [\"T13\"], \"value\": true}}" } ] } ]
11033836_2
Placebo-controlled clinical trials of recombinant human interleukin-11 (rhIL-11, also known as oprelvekin [Neumega]) in patients with nonmyeloid malignancies have demonstrated significant efficacy in preventing postchemotherapy platelet nadirs of < or = 20,000/microL, and reducing the need for platelet transfusions while continuing chemotherapy without dose reductions.
false
[ { "events": [ { "event_id": "E1", "event_type": "Potential_therapeutic_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"preventing\"]], \"start\": [[200]], \"entity_id\": [\"T15\"]}, \"Subject\": {\"text\": [[\"patients with nonmyeloid malignancies\"]], \"start\": [[120]], \"entity_id\": [\"T12\"], \"Disorder\": {\"text\": [[\"nonmyeloid malignancies\"]], \"start\": [[134]], \"entity_id\": [\"T17\"]}}, \"Treatment\": {\"text\": [[\"recombinant human interleukin-11 (rhIL-11, also known as oprelvekin [Neumega])\"]], \"start\": [[38]], \"entity_id\": [\"T11\"], \"Disorder\": {\"text\": [[\"postchemotherapy platelet nadirs of < or = 20,000/microL\"]], \"start\": [[211]], \"entity_id\": [\"T16\"]}, \"Drug\": {\"text\": [[\"recombinant human interleukin-11\"]], \"start\": [[38]], \"entity_id\": [\"T13\"]}}}" } ] } ]
115078_1
A patient with rheumatoid arthritis developed an acute intrahepatic cholestasis after 100 mg of sodium aurothiomalate.
false
[ { "events": [ { "event_id": "E1", "event_type": "Adverse_event", "event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[36]], \"entity_id\": [\"T7\"]}, \"Subject\": {\"text\": [[\"A patient with rheumatoid arthritis\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Effect\": {\"text\": [[\"acute intrahepatic cholestasis\"]], \"start\": [[49]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"100 mg of sodium aurothiomalate\"]], \"start\": [[86]], \"entity_id\": [\"T8\"], \"Disorder\": {\"text\": [[\"rheumatoid arthritis\"]], \"start\": [[15]], \"entity_id\": [\"T4\"]}, \"Dosage\": {\"text\": [[\"100 mg\"]], \"start\": [[86]], \"entity_id\": [\"T10\"]}, \"Drug\": {\"text\": [[\"sodium aurothiomalate\"]], \"start\": [[96]], \"entity_id\": [\"T11\"]}}}" } ] } ]