id
stringlengths 7
11
| context
stringlengths 24
527
| is_mult_event
bool 2
classes | annotations
list |
---|---|---|---|
21887897_2 | A fatal poisoning case involving etizolam, phenobarbital, promethazine and chlorpromazine is presented. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"involving\"]], \"start\": [[23]], \"entity_id\": [\"T9\"]}, \"Treatment\": {\"text\": [[\"etizolam, phenobarbital, promethazine and chlorpromazine\"]], \"start\": [[33]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"etizolam\"], [\"phenobarbital\"], [\"promethazine\"], [\"chlorpromazine\"]], \"start\": [[33], [43], [58], [75]], \"entity_id\": [\"T12\", \"T13\", \"T14\", \"T15\"]}}, \"Effect\": {\"text\": [[\"A fatal poisoning\"]], \"start\": [[0]], \"entity_id\": [\"T8\"]}, \"Subject\": {\"text\": [[\"A fatal poisoning case\"]], \"start\": [[0]], \"entity_id\": [\"T10\"]}, \"Severity\": {\"text\": [[\"fatal\"]], \"start\": [[2]], \"entity_id\": [\"T11\"], \"value\": \"Medium\"}}"
}
]
}
] |
19116715_3 | Rituximab-based therapy for gemcitabine-induced hemolytic uremic syndrome in a patient with metastatic pancreatic adenocarcinoma: a case report. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[40]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"gemcitabine\"]], \"start\": [[28]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"gemcitabine\"]], \"start\": [[28]], \"entity_id\": [\"T8\"]}, \"Disorder\": {\"text\": [[\"metastatic pancreatic adenocarcinoma\"]], \"start\": [[92]], \"entity_id\": [\"T9\"]}}, \"Effect\": {\"text\": [[\"hemolytic uremic syndrome\"]], \"start\": [[48]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"patient with metastatic pancreatic adenocarcinoma\"]], \"start\": [[79]], \"entity_id\": [\"T6\"]}}"
}
]
}
] |
19390192_1 | Leukopenia due to parvovirus B19 in a Crohn's disease patient using azathioprine. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"due\"]], \"start\": [[11]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Leukopenia\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Subject\": {\"text\": [[\"parvovirus B19 in a Crohn's disease patient\"]], \"start\": [[18]], \"entity_id\": [\"T5\"], \"Disorder\": {\"text\": [[\"parvovirus B19\"]], \"start\": [[18]], \"entity_id\": [\"T1\"]}}, \"Treatment\": {\"text\": [[\"azathioprine\"]], \"start\": [[68]], \"entity_id\": [\"T6\"], \"Disorder\": {\"text\": [[\"Crohn's disease\"]], \"start\": [[38]], \"entity_id\": [\"T7\"]}, \"Drug\": {\"text\": [[\"azathioprine\"]], \"start\": [[68]], \"entity_id\": [\"T8\"]}}}"
}
]
}
] |
1477441_3 | Fixed drug eruption of the scrotum due to methylphenidate. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"due\"]], \"start\": [[35]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Fixed drug eruption of the scrotum\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"methylphenidate\"]], \"start\": [[42]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"methylphenidate\"]], \"start\": [[42]], \"entity_id\": [\"T6\"]}}}"
}
]
}
] |
3470173_2 | Cytarabine-induced cerebellar syndrome: case report and literature review. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[11]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"Cytarabine\"]], \"start\": [[0]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"Cytarabine\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"cerebellar syndrome\"]], \"start\": [[19]], \"entity_id\": [\"T5\"]}}"
}
]
}
] |
10513720_2 | We report a case of glaucoma induced by doxetaxel therapy for metastatic breast cancer. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[29]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"a case\"]], \"start\": [[10]], \"entity_id\": [\"T3\"]}, \"Effect\": {\"text\": [[\"glaucoma\"]], \"start\": [[20]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"doxetaxel therapy for metastatic breast cancer\"]], \"start\": [[40]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"doxetaxel\"]], \"start\": [[40]], \"entity_id\": [\"T9\"]}, \"Disorder\": {\"text\": [[\"metastatic breast cancer\"]], \"start\": [[62]], \"entity_id\": [\"T7\"]}}}"
}
]
}
] |
8301877_3 | Myoclonus was induced and enhanced by L-dopa, developing into generalized seizures. | false | [
{
"events": [
{
"event_id": "E2",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E2\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced and enhanced\"]], \"start\": [[14]], \"entity_id\": [\"T9\"]}, \"Treatment\": {\"text\": [[\"L-dopa\"]], \"start\": [[38]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"L-dopa\"]], \"start\": [[38]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"developing into generalized seizures\", \"Myoclonus\"]], \"start\": [[46, 0]], \"entity_id\": [\"T8\"]}}"
}
]
}
] |
15494638_4 | During analysis of 28 patients receiving CAP with concomitant radiation (XRT) for pancreatic cancer (resected or locally advanced), two patients developed signs and symptoms consistent with peripheral neuropathy. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[145]], \"entity_id\": [\"T11\"]}, \"Treatment\": {\"text\": [[\"CAP with concomitant radiation (XRT)\"]], \"start\": [[41]], \"entity_id\": [\"T9\"], \"Disorder\": {\"text\": [[\"pancreatic cancer\"]], \"start\": [[82]], \"entity_id\": [\"T10\"]}, \"Drug\": {\"text\": [[\"CAP\"]], \"start\": [[41]], \"entity_id\": [\"T14\"]}, \"Route\": {\"text\": [[\"concomitant radiation\"]], \"start\": [[50]], \"entity_id\": [\"T15\"]}}, \"Subject\": {\"text\": [[\"two patients\"]], \"start\": [[132]], \"entity_id\": [\"T8\"], \"Population\": {\"text\": [[\"two\"]], \"start\": [[132]], \"entity_id\": [\"T13\"]}}, \"Effect\": {\"text\": [[\"peripheral neuropathy\"]], \"start\": [[190]], \"entity_id\": [\"T12\"]}}"
}
]
}
] |
25515435_8 | A liver biopsy in 2012 revealed marked fibrosis, leading the patient to start hepatitis C treatment with peginterferon alfa-2a, ribavirin and boceprevir. | true | [
{
"events": [
{
"event_id": "E1",
"event_type": "Potential_therapeutic_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"treatment\"]], \"start\": [[90]], \"entity_id\": [\"T10\"]}, \"Subject\": {\"text\": [[\"fibrosis, leading the patient\"]], \"start\": [[39]], \"entity_id\": [\"T9\"]}, \"Treatment\": {\"text\": [[\"peginterferon alfa-2a, ribavirin and boceprevir\"]], \"start\": [[105]], \"entity_id\": [\"T11\"], \"Disorder\": {\"text\": [[\"fibrosis\"]], \"start\": [[39]], \"entity_id\": [\"T8\"]}, \"Drug\": {\"text\": [[\"peginterferon alfa-2a\"], [\"ribavirin\"], [\"boceprevir\"]], \"start\": [[105], [128], [142]], \"entity_id\": [\"T12\", \"T13\", \"T14\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"and\"]], \"start\": [[138]], \"entity_id\": [\"T15\"]}, \"Drug\": {\"text\": [[\"ribavirin\"], [\"boceprevir\"], [\"peginterferon alfa-2a\"]], \"start\": [[128], [142], [105]], \"entity_id\": [\"T13\", \"T14\", \"T12\"]}}]}}"
}
]
}
] |
15494638_19 | Knowledge regarding potential adverse effects of CAP is paramount and dose modification is indicated with development of neurotoxicity. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"adverse effects\"]], \"start\": [[30]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"CAP\"]], \"start\": [[49]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"CAP\"]], \"start\": [[49]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"neurotoxicity\"]], \"start\": [[121]], \"entity_id\": [\"T7\"]}, \"Speculated\": {\"text\": [[\"potential\"]], \"start\": [[20]], \"entity_id\": [\"T9\"], \"value\": true}}"
}
]
}
] |
11111942_2 | We present a case of significant over-anticoagulation temporally associated with a bout of protracted diarrhea in a patient on warfarin therapy. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"over-anticoagulation\"]], \"start\": [[33]], \"entity_id\": [\"T7\"]}, \"Effect\": {\"text\": [[\"protracted diarrhea\"]], \"start\": [[91]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"warfarin\"]], \"start\": [[127]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"warfarin\"]], \"start\": [[127]], \"entity_id\": [\"T8\"]}}}"
}
]
}
] |
11160777_1 | New oral therapies for type 2 diabetes mellitus: | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Potential_therapeutic_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"for\"]], \"start\": [[19]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"oral therapies\"]], \"start\": [[4]], \"entity_id\": [\"T3\"], \"Disorder\": {\"text\": [[\"type 2 diabetes mellitus\"]], \"start\": [[23]], \"entity_id\": [\"T4\"]}, \"Route\": {\"text\": [[\"oral\"]], \"start\": [[4]], \"entity_id\": [\"T7\"]}}}"
}
]
}
] |
10679548_3 | The case histories are presented of two patients who developed lung disease associated with the use of nitrofurantoin with histological features of bronchiolitis obliterans organising pneumonia (BOOP), a rare but recognised form of drug induced injury. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[53]], \"entity_id\": [\"T10\"]}, \"Treatment\": {\"text\": [[\"the use of nitrofurantoin\"]], \"start\": [[92]], \"entity_id\": [\"T8\"], \"Drug\": {\"text\": [[\"nitrofurantoin\"]], \"start\": [[103]], \"entity_id\": [\"T12\"]}}, \"Subject\": {\"text\": [[\"two patients\"]], \"start\": [[36]], \"entity_id\": [\"T7\"], \"Population\": {\"text\": [[\"two\"]], \"start\": [[36]], \"entity_id\": [\"T11\"]}}, \"Effect\": {\"text\": [[\"lung disease\", \"with histological features of bronchiolitis obliterans organising pneumonia (BOOP)\"]], \"start\": [[63, 118]], \"entity_id\": [\"T9\"]}}"
}
]
}
] |
7226916_1 | A 57-year-old woman with right bundle branch block +LPH and ventricular premature contractions developed complete heart block (CHB) following administration of disopyramide phosphate (Norpace). | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[95]], \"entity_id\": [\"T8\"]}, \"Subject\": {\"text\": [[\"A 57-year-old woman with right bundle branch block +LPH and ventricular premature contractions\"]], \"start\": [[0]], \"entity_id\": [\"T7\"], \"Age\": {\"text\": [[\"57-year-old\"]], \"start\": [[2]], \"entity_id\": [\"T11\"]}, \"Gender\": {\"text\": [[\"woman\"]], \"start\": [[14]], \"entity_id\": [\"T12\"]}, \"Disorder\": {\"text\": [[\"right bundle branch block +LPH\"], [\"ventricular premature contractions\"]], \"start\": [[25], [60]], \"entity_id\": [\"T13\", \"T14\"]}}, \"Effect\": {\"text\": [[\"complete heart block (CHB)\"]], \"start\": [[105]], \"entity_id\": [\"T9\"]}, \"Treatment\": {\"text\": [[\"disopyramide phosphate (Norpace)\"]], \"start\": [[160]], \"entity_id\": [\"T10\"], \"Drug\": {\"text\": [[\"disopyramide phosphate\"]], \"start\": [[160]], \"entity_id\": [\"T15\"]}}}"
}
]
}
] |
14700673_3 | METHODS: In an institutional practice setting, two women, aged 25 and 45, developed acute myopia after starting topiramate for epilepsy. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[74]], \"entity_id\": [\"T4\"]}, \"Subject\": {\"text\": [[\"two women, aged 25 and 45\"]], \"start\": [[47]], \"entity_id\": [\"T3\"], \"Population\": {\"text\": [[\"two\"]], \"start\": [[47]], \"entity_id\": [\"T8\"]}, \"Gender\": {\"text\": [[\"women\"]], \"start\": [[51]], \"entity_id\": [\"T9\"]}, \"Age\": {\"text\": [[\"aged 25 and 45\"]], \"start\": [[58]], \"entity_id\": [\"T10\"]}}, \"Effect\": {\"text\": [[\"acute myopia\"]], \"start\": [[84]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"topiramate\"]], \"start\": [[112]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"topiramate\"]], \"start\": [[112]], \"entity_id\": [\"T11\"]}, \"Disorder\": {\"text\": [[\"epilepsy\"]], \"start\": [[127]], \"entity_id\": [\"T12\"]}}}"
}
]
}
] |
16411025_2 | Diffusion-weighted MRI correlates of subacute methotrexate-related neurotoxicity. | false | [
{
"events": [
{
"event_id": "E2",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E2\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"related\"]], \"start\": [[59]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"subacute\", \"neurotoxicity\"]], \"start\": [[37, 67]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"methotrexate\"]], \"start\": [[46]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"methotrexate\"]], \"start\": [[46]], \"entity_id\": [\"T3\"]}}}"
}
]
}
] |
16298824_3 | ARDS is rarely associated with rituximab infusion for lympho-proliferative disorders, but it should be considered by those administering rituximab, especially when a patient develops severe pulmonary symptoms soon after infusion. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[214]], \"entity_id\": [\"T8\"]}, \"Subject\": {\"text\": [[\"a patient\"]], \"start\": [[164]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"ARDS\", \"severe pulmonary symptoms\"]], \"start\": [[0, 183]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"infusion\"], [\"rituximab\"]], \"start\": [[220], [137]], \"entity_id\": [\"T9\", \"T10\"], \"Route\": {\"text\": [[\"infusion\"]], \"start\": [[220]], \"entity_id\": [\"T13\"]}, \"Drug\": {\"text\": [[\"rituximab\"]], \"start\": [[137]], \"entity_id\": [\"T11\"]}}}"
}
]
}
] |
7351000_3 | Seven of the eight cases of acute leukemia occurred in a series of 553 patients treated with Treosulfan for ovarian cancer in the period from 1970 to 1977 and followed closely for a total of 1159 patient-years up to February 1978. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"occurred\"]], \"start\": [[43]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"acute leukemia\"]], \"start\": [[28]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"Treosulfan\"]], \"start\": [[93]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"Treosulfan\"]], \"start\": [[93]], \"entity_id\": [\"T10\"]}, \"Disorder\": {\"text\": [[\"ovarian cancer\"]], \"start\": [[108]], \"entity_id\": [\"T11\"]}}, \"Subject\": {\"text\": [[\"Seven of the eight cases\"]], \"start\": [[0]], \"entity_id\": [\"T6\"], \"Population\": {\"text\": [[\"eight\"]], \"start\": [[13]], \"entity_id\": [\"T7\"]}}}"
}
]
}
] |
6833205_2 | Desipramine-associated SIADH in an elderly woman: case report. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[12]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"Desipramine\"]], \"start\": [[0]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"Desipramine\"]], \"start\": [[0]], \"entity_id\": [\"T9\"]}}, \"Effect\": {\"text\": [[\"SIADH\"]], \"start\": [[23]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"an elderly woman\"]], \"start\": [[32]], \"entity_id\": [\"T6\"], \"Age\": {\"text\": [[\"elderly\"]], \"start\": [[35]], \"entity_id\": [\"T7\"]}, \"Gender\": {\"text\": [[\"woman\"]], \"start\": [[43]], \"entity_id\": [\"T8\"]}}}"
}
]
}
] |
16146480_1 | Can propofol precipitate pancreatitis in patients with Cushing's syndrome? | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"precipitate\"]], \"start\": [[13]], \"entity_id\": [\"T4\"]}, \"Subject\": {\"text\": [[\"patients with Cushing's syndrome?\"]], \"start\": [[41]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"propofol\"]], \"start\": [[4]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"propofol\"]], \"start\": [[4]], \"entity_id\": [\"T8\"]}, \"Disorder\": {\"text\": [[\"Cushing's syndrome\"]], \"start\": [[55]], \"entity_id\": [\"T10\"]}}, \"Effect\": {\"text\": [[\"pancreatitis\"]], \"start\": [[25]], \"entity_id\": [\"T6\"]}, \"Speculated\": {\"text\": [[\"Can\"]], \"start\": [[0]], \"entity_id\": [\"T9\"], \"value\": true}}"
}
]
}
] |
23552010_3 | This case presents the possibility of anaphylaxis to topical 5-FU treatments and/or the interaction with angiotensin converting enzyme inhibitors. | true | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"to\"]], \"start\": [[50]], \"entity_id\": [\"T9\"]}, \"Effect\": {\"text\": [[\"anaphylaxis\"]], \"start\": [[38]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"5-FU\", \"angiotensin converting enzyme inhibitors\"]], \"start\": [[61, 105]], \"entity_id\": [\"T8\"], \"Drug\": {\"text\": [[\"5-FU\"], [\"angiotensin converting enzyme inhibitors\"]], \"start\": [[61], [105]], \"entity_id\": [\"T10\", \"T11\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"interaction\"]], \"start\": [[88]], \"entity_id\": [\"T12\"]}, \"Drug\": {\"text\": [[\"angiotensin converting enzyme inhibitors\"], [\"5-FU\"]], \"start\": [[105], [61]], \"entity_id\": [\"T11\", \"T10\"]}}]}, \"Speculated\": {\"text\": [[\"possibility\"]], \"start\": [[23]], \"entity_id\": [\"T13\"], \"value\": true}}"
}
]
}
] |
15331204_8 | After stopping indapamide, glucose tolerance impairing may be reversed. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Potential_therapeutic_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"stopping\"]], \"start\": [[6]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"indapamide, glucose tolerance impairing\"]], \"start\": [[15]], \"entity_id\": [\"T5\"], \"Disorder\": {\"text\": [[\"glucose tolerance impairing\"]], \"start\": [[27]], \"entity_id\": [\"T3\"]}, \"Drug\": {\"text\": [[\"indapamide\"]], \"start\": [[15]], \"entity_id\": [\"T9\"]}}, \"Speculated\": {\"text\": [[\"may\"]], \"start\": [[55]], \"entity_id\": [\"T7\"], \"value\": true}}"
}
]
}
] |
11424102_3 | We describe a case of needle-track cutaneous seeding of hepatocellular carcinoma (HCC) after sonographically guided percutaneous ethanol injection (PEI). | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[87]], \"entity_id\": [\"T7\"]}, \"Effect\": {\"text\": [[\"needle-track cutaneous seeding of hepatocellular carcinoma\"]], \"start\": [[22]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"sonographically guided percutaneous ethanol injection\"]], \"start\": [[93]], \"entity_id\": [\"T8\"], \"Route\": {\"text\": [[\"injection\"]], \"start\": [[137]], \"entity_id\": [\"T9\"]}, \"Drug\": {\"text\": [[\"ethanol\"]], \"start\": [[129]], \"entity_id\": [\"T10\"]}}}"
}
]
}
] |
8083821_3 | Zidovudine use in pregnancy: a report on 104 cases and the occurrence of birth defects. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"occurrence\"]], \"start\": [[59]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"Zidovudine\"]], \"start\": [[0]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"Zidovudine\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"birth defects\"]], \"start\": [[73]], \"entity_id\": [\"T5\"]}}"
}
]
}
] |
2369419_1 | A patient with seropositive rheumatoid arthritis developed ascites while taking weekly doses of methotrexate (MTX). | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[49]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"A patient with seropositive rheumatoid arthritis\"]], \"start\": [[0]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"ascites\"]], \"start\": [[59]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"taking weekly doses of methotrexate (MTX)\"]], \"start\": [[73]], \"entity_id\": [\"T7\"], \"Disorder\": {\"text\": [[\"seropositive rheumatoid arthritis\"]], \"start\": [[15]], \"entity_id\": [\"T8\"]}, \"Freq\": {\"text\": [[\"weekly\"]], \"start\": [[80]], \"entity_id\": [\"T9\"]}, \"Drug\": {\"text\": [[\"methotrexate\"]], \"start\": [[96]], \"entity_id\": [\"T10\"]}}}"
}
]
}
] |
18453852_1 | High incidence of adverse events in healthy volunteers receiving rifampicin and adjusted doses of lopinavir/ritonavir tablets. | true | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"receiving\"]], \"start\": [[55]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"rifampicin and adjusted doses of lopinavir/ritonavir tablets\"]], \"start\": [[65]], \"entity_id\": [\"T8\"], \"Drug\": {\"text\": [[\"rifampicin\"], [\"lopinavir\"], [\"ritonavir\"]], \"start\": [[65], [98], [108]], \"entity_id\": [\"T11\", \"T13\", \"T14\"]}, \"Route\": {\"text\": [[\"tablets\"]], \"start\": [[118]], \"entity_id\": [\"T12\"]}, \"Dosage\": {\"text\": [[\"adjusted doses\"]], \"start\": [[80]], \"entity_id\": [\"T16\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"and\"]], \"start\": [[76]], \"entity_id\": [\"T15\"]}, \"Drug\": {\"text\": [[\"rifampicin\"], [\"lopinavir\"], [\"ritonavir\"]], \"start\": [[65], [98], [108]], \"entity_id\": [\"T11\", \"T13\", \"T14\"]}}]}, \"Subject\": {\"text\": [[\"healthy volunteers\"]], \"start\": [[36]], \"entity_id\": [\"T9\"]}, \"Effect\": {\"text\": [[\"High incidence of adverse events\"]], \"start\": [[0]], \"entity_id\": [\"T10\"]}}"
}
]
}
] |
14735388_2 | We report here a case of TEN after administration of ciprofloxacin. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"administration\"]], \"start\": [[35]], \"entity_id\": [\"T6\"]}, \"Subject\": {\"text\": [[\"a case\"]], \"start\": [[15]], \"entity_id\": [\"T3\"]}, \"Effect\": {\"text\": [[\"TEN\"]], \"start\": [[25]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"ciprofloxacin\"]], \"start\": [[53]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"ciprofloxacin\"]], \"start\": [[53]], \"entity_id\": [\"T7\"]}}}"
}
]
}
] |
20120657_3 | Zidovudine induced pure red cell aplasia: a case report. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[11]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"Zidovudine\"]], \"start\": [[0]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"Zidovudine\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"pure red cell aplasia\"]], \"start\": [[19]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"a case\"]], \"start\": [[42]], \"entity_id\": [\"T7\"]}}"
}
]
}
] |
17406804_1 | A case of recall pneumonitis induced by gemcitabine is reported. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[29]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"gemcitabine\"]], \"start\": [[40]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"gemcitabine\"]], \"start\": [[40]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"recall pneumonitis\"]], \"start\": [[10]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"A case\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}}"
}
]
}
] |
7893301_1 | Albuterol-induced hypokalemia and its potential cardiac toxicity are discussed briefly. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[10]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"Albuterol\"]], \"start\": [[0]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"Albuterol\"]], \"start\": [[0]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"hypokalemia and its potential cardiac toxicity\"]], \"start\": [[18]], \"entity_id\": [\"T7\"]}}"
}
]
}
] |
9653495_15 | In the absence of an ideal dose-intense FU monotherapy regimen, monthly FU with low-dose LV provides a simple and economical means by which to achieve adequate FU efficacy in the treatment of advanced colorectal cancer. | true | [
{
"events": [
{
"event_id": "E1",
"event_type": "Potential_therapeutic_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"treatment\"]], \"start\": [[179]], \"entity_id\": [\"T8\"]}, \"Treatment\": {\"text\": [[\"monthly FU with low-dose LV\"]], \"start\": [[64]], \"entity_id\": [\"T10\"], \"Disorder\": {\"text\": [[\"advanced colorectal cancer\"]], \"start\": [[192]], \"entity_id\": [\"T9\"]}, \"Freq\": {\"text\": [[\"monthly\"]], \"start\": [[64]], \"entity_id\": [\"T11\"]}, \"Drug\": {\"text\": [[\"FU\"], [\"LV\"]], \"start\": [[72], [89]], \"entity_id\": [\"T12\", \"T14\"]}, \"Dosage\": {\"text\": [[\"low-dose\"]], \"start\": [[80]], \"entity_id\": [\"T15\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"with\"]], \"start\": [[75]], \"entity_id\": [\"T13\"]}, \"Drug\": {\"text\": [[\"FU\"], [\"LV\"]], \"start\": [[72], [89]], \"entity_id\": [\"T12\", \"T14\"]}}]}}"
}
]
}
] |
12503933_6 | OBJECTIVE: To report a patient developing fulminant liver failure while being treated with clarithromycin for pneumonia. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"treated\"]], \"start\": [[78]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"fulminant liver failure\"]], \"start\": [[42]], \"entity_id\": [\"T3\"]}, \"Subject\": {\"text\": [[\"a patient\"]], \"start\": [[21]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"clarithromycin\"]], \"start\": [[91]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"clarithromycin\"]], \"start\": [[91]], \"entity_id\": [\"T7\"]}, \"Disorder\": {\"text\": [[\"pneumonia\"]], \"start\": [[110]], \"entity_id\": [\"T8\"]}}}"
}
]
}
] |
6529939_3 | The abnormal rhythm disappeared with the withdrawal of propranolol and when the drug was restarted a 2/1 S-A block was seen. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"seen\"]], \"start\": [[119]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"propranolol\"]], \"start\": [[55]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"propranolol\"]], \"start\": [[55]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"2/1 S-A block\"]], \"start\": [[101]], \"entity_id\": [\"T4\"]}}"
}
]
}
] |
19826099_3 | The Naranjo probability scale indicated a probable relationship between apnea and exposure to lamotrigine through breast-feeding in this infant. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"a probable relationship\"]], \"start\": [[40]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"apnea\"]], \"start\": [[72]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"lamotrigine through breast-feeding\"]], \"start\": [[94]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"lamotrigine\"]], \"start\": [[94]], \"entity_id\": [\"T8\"]}, \"Route\": {\"text\": [[\"breast-feeding\"]], \"start\": [[114]], \"entity_id\": [\"T10\"]}}, \"Subject\": {\"text\": [[\"in this infant\"]], \"start\": [[129]], \"entity_id\": [\"T6\"], \"Age\": {\"text\": [[\"infant\"]], \"start\": [[137]], \"entity_id\": [\"T7\"]}}, \"Speculated\": {\"text\": [[\"probable\"]], \"start\": [[42]], \"entity_id\": [\"T9\"], \"value\": true}}"
}
]
}
] |
16757971_2 | Listeria brain abscess, Pneumocystis pneumonia and Kaposi's sarcoma after temozolomide. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[68]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"temozolomide\"]], \"start\": [[74]], \"entity_id\": [\"T8\"], \"Drug\": {\"text\": [[\"temozolomide\"]], \"start\": [[74]], \"entity_id\": [\"T10\"]}}, \"Effect\": {\"text\": [[\"Listeria brain abscess, Pneumocystis pneumonia and Kaposi's sarcoma\"]], \"start\": [[0]], \"entity_id\": [\"T9\"]}}"
}
]
}
] |
9920368_3 | Since amiodarone was first marketed in 1992 in Japan, the incidence of amiodarone-induced thyrotoxicosis (AIT) has been increasing. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[82]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"amiodarone\"]], \"start\": [[71]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"amiodarone\"], [\"amiodarone\"]], \"start\": [[71], [6]], \"entity_id\": [\"T8\", \"T9\"]}}, \"Effect\": {\"text\": [[\"thyrotoxicosis (AIT)\"]], \"start\": [[90]], \"entity_id\": [\"T7\"]}}"
}
]
}
] |
7619765_2 | The occurrence of a myocardial infarction is reported after chemotherapy containing etoposide, in a man with no risk factors for coronary heart disease. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[54]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"chemotherapy containing etoposide\"]], \"start\": [[60]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"etoposide\"]], \"start\": [[84]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"myocardial infarction\"]], \"start\": [[20]], \"entity_id\": [\"T4\"]}, \"Subject\": {\"text\": [[\"a man with no risk factors for coronary heart disease\"]], \"start\": [[98]], \"entity_id\": [\"T5\"], \"Gender\": {\"text\": [[\"man\"]], \"start\": [[100]], \"entity_id\": [\"T7\"]}}}"
}
]
}
] |
889156_1 | The use of beclomethasone diproprionate inhaler complicated by the development of an eosinophilic pneumonia reaction. | false | [
{
"events": [
{
"event_id": "E2",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E2\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"development\"]], \"start\": [[67]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"beclomethasone diproprionate inhaler\"]], \"start\": [[11]], \"entity_id\": [\"T4\"], \"Route\": {\"text\": [[\"inhaler\"]], \"start\": [[40]], \"entity_id\": [\"T5\"]}, \"Drug\": {\"text\": [[\"beclomethasone diproprionate\"]], \"start\": [[11]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"eosinophilic pneumonia reaction\"]], \"start\": [[85]], \"entity_id\": [\"T6\"]}}"
}
]
}
] |
7577414_1 | Nephrotic syndrome related to systemic lupus erythematosus after griseofulvin therapy. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[59]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"griseofulvin\"]], \"start\": [[65]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"griseofulvin\"]], \"start\": [[65]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"Nephrotic syndrome related to systemic lupus erythematosus\"]], \"start\": [[0]], \"entity_id\": [\"T7\"]}}"
}
]
}
] |
9554064_3 | Theoretical basal ganglia toxicologic mechanisms of methanol poisoning are reviewed, and the role of brain imaging studies will regard to diagnosis, prognosis and impact on management is discussed. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"mechanisms\"]], \"start\": [[38]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"methanol\"]], \"start\": [[52]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"methanol\"]], \"start\": [[52]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"poisoning\"]], \"start\": [[61]], \"entity_id\": [\"T4\"]}}"
}
]
}
] |
8485005_3 | We report a case of drug-induced Kaposi's sarcoma (KS) on the sole of the right foot in a 71-year-old man, treated for 6 months with corticosteroid therapy (prednisolone 25 mg/day) for pericardial effusion. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[25]], \"entity_id\": [\"T10\"]}, \"Subject\": {\"text\": [[\"a case of\", \"a 71-year-old man\", \"for pericardial effusion\"]], \"start\": [[10, 88, 181]], \"entity_id\": [\"T9\"], \"Age\": {\"text\": [[\"71-year-old\"]], \"start\": [[90]], \"entity_id\": [\"T13\"]}, \"Gender\": {\"text\": [[\"man\"]], \"start\": [[102]], \"entity_id\": [\"T14\"]}}, \"Effect\": {\"text\": [[\"Kaposi's sarcoma (KS)\"]], \"start\": [[33]], \"entity_id\": [\"T11\"]}, \"Treatment\": {\"text\": [[\"6 months with corticosteroid therapy (prednisolone 25 mg/day)\"]], \"start\": [[119]], \"entity_id\": [\"T12\"], \"Duration\": {\"text\": [[\"6 months\"]], \"start\": [[119]], \"entity_id\": [\"T16\"]}, \"Dosage\": {\"text\": [[\"25 mg/day\"]], \"start\": [[170]], \"entity_id\": [\"T17\"]}, \"Drug\": {\"text\": [[\"prednisolone\"]], \"start\": [[157]], \"entity_id\": [\"T19\"]}, \"Disorder\": {\"text\": [[\"pericardial effusion\"]], \"start\": [[185]], \"entity_id\": [\"T20\"]}}}"
}
]
}
] |
16196187_3 | We present a case of acute epinephrine toxicity resulting in acute myocardial ischemia in a young boy with combined variable immunodeficiency syndrome who developed severe allergic reaction to intravenous immunoglobulin, and was subsequently given epinephrine by mistake intravenously rather than subcutaneously. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"toxicity\"]], \"start\": [[39]], \"entity_id\": [\"T7\"]}, \"Subject\": {\"text\": [[\"a young boy with combined variable immunodeficiency syndrome\"]], \"start\": [[90]], \"entity_id\": [\"T6\"], \"Age\": {\"text\": [[\"young\"]], \"start\": [[92]], \"entity_id\": [\"T10\"]}, \"Gender\": {\"text\": [[\"boy\"]], \"start\": [[98]], \"entity_id\": [\"T11\"]}}, \"Treatment\": {\"text\": [[\"acute epinephrine\", \"intravenous immunoglobulin, and was subsequently given epinephrine by mistake intravenously rather than subcutaneously\"]], \"start\": [[21, 193]], \"entity_id\": [\"T8\"], \"Drug\": {\"text\": [[\"epinephrine\"], [\"immunoglobulin\"]], \"start\": [[27], [205]], \"entity_id\": [\"T13\", \"T19\"]}, \"Disorder\": {\"text\": [[\"combined variable immunodeficiency syndrome\"]], \"start\": [[107]], \"entity_id\": [\"T15\"]}, \"Route\": {\"text\": [[\"intravenously\"], [\"intravenous\"]], \"start\": [[271], [193]], \"entity_id\": [\"T16\", \"T18\"]}}, \"Effect\": {\"text\": [[\"acute myocardial ischemia\", \"severe allergic reaction\"]], \"start\": [[61, 165]], \"entity_id\": [\"T9\"]}}"
}
]
}
] |
8363533_1 | Albeit rare among Western patients, such lithium-associated thyroid dysfunctions appeared to be more likely to occur in Hong Kong Chinese. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[49]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"lithium\"]], \"start\": [[41]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"lithium\"]], \"start\": [[41]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"thyroid dysfunctions\"]], \"start\": [[60]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"Hong Kong Chinese\"]], \"start\": [[120]], \"entity_id\": [\"T6\"], \"Race\": {\"text\": [[\"Hong Kong Chinese\"]], \"start\": [[120]], \"entity_id\": [\"T7\"]}}}"
}
]
}
] |
25671244_2 | Metaxalone has only recently been associated with serotonin syndrome. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[34]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"serotonin syndrome\"]], \"start\": [[50]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"Metaxalone\"]], \"start\": [[0]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"Metaxalone\"]], \"start\": [[0]], \"entity_id\": [\"T8\"]}}}"
}
]
}
] |
19235747_1 | Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is reported in up to 18.6% of patients treated with intravenous bisphosphonates and can result in significant morbidity. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"related\"]], \"start\": [[15]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"osteonecrosis of the jaw (BRONJ)\"]], \"start\": [[23]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"18.6% of patients\"]], \"start\": [[77]], \"entity_id\": [\"T6\"], \"Population\": {\"text\": [[\"18.6%\"]], \"start\": [[77]], \"entity_id\": [\"T3\"]}}, \"Treatment\": {\"text\": [[\"intravenous bisphosphonates\"]], \"start\": [[108]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"Bisphosphonate\"], [\"bisphosphonates\"]], \"start\": [[0], [120]], \"entity_id\": [\"T8\", \"T10\"]}, \"Route\": {\"text\": [[\"intravenous\"]], \"start\": [[108]], \"entity_id\": [\"T9\"]}}, \"Severity\": {\"text\": [[\"significant\"]], \"start\": [[154]], \"entity_id\": [\"T11\"], \"value\": \"High\"}}"
}
]
}
] |
8691927_3 | Growth and adrenal suppression in asthmatic children treated with high-dose fluticasone propionate. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Potential_therapeutic_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"in\"]], \"start\": [[31]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"Growth and adrenal suppression\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Subject\": {\"text\": [[\"asthmatic children\"]], \"start\": [[34]], \"entity_id\": [\"T4\"], \"Age\": {\"text\": [[\"children\"]], \"start\": [[44]], \"entity_id\": [\"T8\"]}}, \"Treatment\": {\"text\": [[\"high-dose fluticasone propionate\"]], \"start\": [[66]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"fluticasone propionate\"]], \"start\": [[76]], \"entity_id\": [\"T9\"]}, \"Dosage\": {\"text\": [[\"high-dose\"]], \"start\": [[66]], \"entity_id\": [\"T10\"]}, \"Disorder\": {\"text\": [[\"asthmatic\"]], \"start\": [[34]], \"entity_id\": [\"T11\"]}}}"
}
]
}
] |
14674674_1 | A diagnosis of infliximab-induced lupus was made and the drug treatment was withdrawn. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[26]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"infliximab\"]], \"start\": [[15]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"infliximab\"]], \"start\": [[15]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"lupus\"]], \"start\": [[34]], \"entity_id\": [\"T5\"]}}"
}
]
}
] |
10510156_2 | AIMS: To identify the human cytochrome P450 enzyme (s) involved in the in vitro metabolism of rosiglitazone, a potential oral antidiabetic agent for the treatment of type 2 diabetes-mellitus. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Potential_therapeutic_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"potential oral\"]], \"start\": [[112]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"rosiglitazone\"]], \"start\": [[95]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"rosiglitazone\"]], \"start\": [[95]], \"entity_id\": [\"T10\"]}, \"Disorder\": {\"text\": [[\"type 2 diabetes-mellitus.\"]], \"start\": [[167]], \"entity_id\": [\"T11\"]}, \"Route\": {\"text\": [[\"oral\"]], \"start\": [[122]], \"entity_id\": [\"T12\"]}}}"
}
]
}
] |
2011096_5 | Neurotoxicity can occur at any time using high-dose cytosine therapy. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"occur\"]], \"start\": [[18]], \"entity_id\": [\"T7\"]}, \"Effect\": {\"text\": [[\"Neurotoxicity\"]], \"start\": [[0]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"high-dose cytosine\"]], \"start\": [[42]], \"entity_id\": [\"T6\"], \"Dosage\": {\"text\": [[\"high-dose\"]], \"start\": [[42]], \"entity_id\": [\"T9\"]}, \"Drug\": {\"text\": [[\"cytosine\"]], \"start\": [[52]], \"entity_id\": [\"T10\"]}}}"
}
]
}
] |
3677571_15 | The possibility of phenytoin hypersensitivity reactions should be considered when patients receiving phenytoin have unusual symptoms, particularly fever, rash, and lymphadenopathy. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"receiving\"]], \"start\": [[91]], \"entity_id\": [\"T11\"]}, \"Effect\": {\"text\": [[\"phenytoin hypersensitivity\", \"fever, rash, and lymphadenopathy\"]], \"start\": [[19, 147]], \"entity_id\": [\"T10\"]}, \"Treatment\": {\"text\": [[\"phenytoin\"]], \"start\": [[101]], \"entity_id\": [\"T12\"], \"Drug\": {\"text\": [[\"phenytoin\"]], \"start\": [[101]], \"entity_id\": [\"T14\"]}}, \"Speculated\": {\"text\": [[\"possibility\"]], \"start\": [[4]], \"entity_id\": [\"T13\"], \"value\": true}}"
}
]
}
] |
9360190_2 | Magnesium tocolysis as the cause of urinary calculus during pregnancy. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"cause\"]], \"start\": [[27]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"Magnesium tocolysis\"]], \"start\": [[0]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"Magnesium\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"urinary calculus during pregnancy\"]], \"start\": [[36]], \"entity_id\": [\"T5\"]}}"
}
]
}
] |
14601701_1 | Ocular ethambutol toxicity. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"toxicity\"]], \"start\": [[18]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"toxicity\"]], \"start\": [[18]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"Ocular ethambutol\"]], \"start\": [[0]], \"entity_id\": [\"T4\"], \"Route\": {\"text\": [[\"Ocular\"]], \"start\": [[0]], \"entity_id\": [\"T7\"]}, \"Drug\": {\"text\": [[\"ethambutol\"]], \"start\": [[7]], \"entity_id\": [\"T8\"]}}}"
}
]
}
] |
8891729_1 | Fatal intravascular autoimmune hemolytic anemia after fludarabine treatment for chronic lymphocytic leukemia. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[48]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Fatal intravascular autoimmune hemolytic anemia\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"fludarabine treatment\"]], \"start\": [[54]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"fludarabine\"]], \"start\": [[54]], \"entity_id\": [\"T7\"]}, \"Disorder\": {\"text\": [[\"chronic lymphocytic leukemia\"]], \"start\": [[80]], \"entity_id\": [\"T8\"]}}, \"Severity\": {\"text\": [[\"Fatal\"]], \"start\": [[0]], \"entity_id\": [\"T9\"], \"value\": \"High\"}}"
}
]
}
] |
14557583_1 | A 74-year-old patient with idiopathic Parkinson's disease was evaluated for unintended sleep episodes that occurred after long-term treatment with 400 mg/day of L-dopa. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"after\"]], \"start\": [[116]], \"entity_id\": [\"T6\"]}, \"Subject\": {\"text\": [[\"A 74-year-old patient with idiopathic Parkinson's disease\"]], \"start\": [[0]], \"entity_id\": [\"T3\"], \"Age\": {\"text\": [[\"74-year-old\"]], \"start\": [[2]], \"entity_id\": [\"T7\"]}}, \"Treatment\": {\"text\": [[\"long-term treatment with 400 mg/day of L-dopa\"]], \"start\": [[122]], \"entity_id\": [\"T4\"], \"Disorder\": {\"text\": [[\"idiopathic Parkinson's disease\"]], \"start\": [[27]], \"entity_id\": [\"T8\"]}, \"Dosage\": {\"text\": [[\"400 mg/day\"]], \"start\": [[147]], \"entity_id\": [\"T9\"]}, \"Drug\": {\"text\": [[\"L-dopa\"]], \"start\": [[161]], \"entity_id\": [\"T10\"]}, \"Duration\": {\"text\": [[\"long-term treatment\"]], \"start\": [[122]], \"entity_id\": [\"T11\"]}}, \"Effect\": {\"text\": [[\"unintended sleep episodes\"]], \"start\": [[76]], \"entity_id\": [\"T5\"]}}"
}
]
}
] |
6683487_2 | Thrombotic thrombocytopenic purpura (TTP) developed in a patient with seropositive rheumatoid arthritis (RA) after 2 1/2 months of treatment with penicillamine. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[42]], \"entity_id\": [\"T10\"]}, \"Effect\": {\"text\": [[\"Thrombotic thrombocytopenic purpura (TTP)\"]], \"start\": [[0]], \"entity_id\": [\"T9\"]}, \"Subject\": {\"text\": [[\"a patient with seropositive rheumatoid arthritis (RA)\"]], \"start\": [[55]], \"entity_id\": [\"T11\"]}, \"Treatment\": {\"text\": [[\"2 1/2 months of treatment with penicillamine\"]], \"start\": [[115]], \"entity_id\": [\"T12\"], \"Disorder\": {\"text\": [[\"rheumatoid arthritis\"]], \"start\": [[83]], \"entity_id\": [\"T13\"]}, \"Drug\": {\"text\": [[\"penicillamine\"]], \"start\": [[146]], \"entity_id\": [\"T14\"]}, \"Duration\": {\"text\": [[\"2 1/2 months\"]], \"start\": [[115]], \"entity_id\": [\"T1\"]}}}"
}
]
}
] |
9337441_1 | Phenolphthalein-induced toxic epidermal necrolysis. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[16]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"Phenolphthalein\"]], \"start\": [[0]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"Phenolphthalein\"]], \"start\": [[0]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"toxic epidermal necrolysis\"]], \"start\": [[24]], \"entity_id\": [\"T6\"]}}"
}
]
}
] |
1536494_2 | We present a case of ethylenediamine-induced delayed hypersensitivity reaction in a 46-year-old woman who received parenteral aminophylline for an acute asthma exacerbation. | true | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[37]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"ethylenediamine\"]], \"start\": [[21]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"ethylenediamine\"]], \"start\": [[21]], \"entity_id\": [\"T11\"]}}, \"Effect\": {\"text\": [[\"delayed hypersensitivity reaction\"]], \"start\": [[45]], \"entity_id\": [\"T6\"]}, \"Subject\": {\"text\": [[\"a 46-year-old woman\"]], \"start\": [[82]], \"entity_id\": [\"T7\"], \"Age\": {\"text\": [[\"46-year-old\"]], \"start\": [[84]], \"entity_id\": [\"T9\"]}, \"Gender\": {\"text\": [[\"woman\"]], \"start\": [[96]], \"entity_id\": [\"T10\"]}}}"
},
{
"event_id": "E2",
"event_type": "Potential_therapeutic_event",
"event_data": "{\"event_id\": \"E2\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"received\"]], \"start\": [[106]], \"entity_id\": [\"T13\"]}, \"Subject\": {\"text\": [[\"a 46-year-old woman\"]], \"start\": [[82]], \"entity_id\": [\"T7\"], \"Age\": {\"text\": [[\"46-year-old\"]], \"start\": [[84]], \"entity_id\": [\"T9\"]}, \"Gender\": {\"text\": [[\"woman\"]], \"start\": [[96]], \"entity_id\": [\"T10\"]}}, \"Treatment\": {\"text\": [[\"parenteral aminophylline\"]], \"start\": [[115]], \"entity_id\": [\"T14\"], \"Disorder\": {\"text\": [[\"acute asthma exacerbation\"]], \"start\": [[147]], \"entity_id\": [\"T8\"]}, \"Route\": {\"text\": [[\"parenteral\"]], \"start\": [[115]], \"entity_id\": [\"T15\"]}, \"Drug\": {\"text\": [[\"aminophylline\"]], \"start\": [[126]], \"entity_id\": [\"T16\"]}}}"
}
]
}
] |
8730143_2 | Physicians should be aware of the potentially lethal side effects of dapsone. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"of\"]], \"start\": [[66]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"dapsone\"]], \"start\": [[69]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"dapsone\"]], \"start\": [[69]], \"entity_id\": [\"T8\"]}}, \"Effect\": {\"text\": [[\"lethal side effects\"]], \"start\": [[46]], \"entity_id\": [\"T5\"]}, \"Speculated\": {\"text\": [[\"potentially\"]], \"start\": [[34]], \"entity_id\": [\"T6\"], \"value\": true}, \"Severity\": {\"text\": [[\"lethal\"]], \"start\": [[46]], \"entity_id\": [\"T7\"], \"value\": \"High\"}}"
}
]
}
] |
3753891_1 | Acute myocardial necrosis during administration of amsacrine. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"during\"]], \"start\": [[26]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Acute myocardial necrosis\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"amsacrine\"]], \"start\": [[51]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"amsacrine\"]], \"start\": [[51]], \"entity_id\": [\"T6\"]}}}"
}
]
}
] |
12699871_2 | Rapid identification of speech loss linked to FK506 may be important because reduction or cessation of the drug may be associated with reverse of speech loss. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"linked\"]], \"start\": [[36]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"speech loss\"]], \"start\": [[24]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"FK506\"]], \"start\": [[46]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"FK506\"]], \"start\": [[46]], \"entity_id\": [\"T7\"]}}}"
}
]
}
] |
667809_2 | Fatal pulmonary fibrosis following 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapy. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"following\"]], \"start\": [[25]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"pulmonary fibrosis\"]], \"start\": [[6]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapy\"]], \"start\": [[35]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)\"]], \"start\": [[35]], \"entity_id\": [\"T7\"]}}, \"Severity\": {\"text\": [[\"Fatal\"]], \"start\": [[0]], \"entity_id\": [\"T8\"], \"value\": \"High\"}}"
}
]
}
] |
8862924_4 | The increasing prevalence of methamphetamine abuse and the severity of the associated ulcers should alert ophthalmologists to the problem of methamphetamine-related keratitis. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"related\"]], \"start\": [[157]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"associated ulcers\", \"keratitis\"]], \"start\": [[75, 165]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"methamphetamine abuse\", \"methamphetamine\"]], \"start\": [[29, 141]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"methamphetamine\"], [\"methamphetamine\"]], \"start\": [[29], [141]], \"entity_id\": [\"T9\", \"T10\"]}}, \"Severity\": {\"text\": [[\"severity\"]], \"start\": [[59]], \"entity_id\": [\"T8\"], \"value\": \"Medium\"}}"
}
]
}
] |
15735923_5 | MDS was diagnosed 8.4 months after beginning TMZ. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"diagnosed\"]], \"start\": [[8]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"MDS\"]], \"start\": [[0]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"8.4 months after beginning TMZ\"]], \"start\": [[18]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"TMZ\"]], \"start\": [[45]], \"entity_id\": [\"T7\"]}, \"Time_elapsed\": {\"text\": [[\"8.4 months\"]], \"start\": [[18]], \"entity_id\": [\"T8\"]}}}"
}
]
}
] |
8979664_3 | Uveitis associated with rifabutin therapy: a clinical alert. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[8]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Uveitis\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"rifabutin therapy\"]], \"start\": [[24]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"rifabutin\"]], \"start\": [[24]], \"entity_id\": [\"T6\"]}}}"
}
]
}
] |
18698687_3 | We report a case of a patient with ciprofloxacin-induced SJS and acute onset of VBDS, and reviewed the related literature. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[49]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"ciprofloxacin\"]], \"start\": [[35]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"ciprofloxacin\"]], \"start\": [[35]], \"entity_id\": [\"T10\"]}}, \"Effect\": {\"text\": [[\"SJS\"], [\"acute onset of VBDS\"]], \"start\": [[57], [65]], \"entity_id\": [\"T7\", \"T8\"]}, \"Subject\": {\"text\": [[\"a patient\"]], \"start\": [[20]], \"entity_id\": [\"T9\"]}}"
}
]
}
] |
8880251_3 | This case supports the assessment that MH and diabetes are associated diseases and that cresol could possibly trigger MH. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"trigger\"]], \"start\": [[110]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"cresol\"]], \"start\": [[88]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"cresol\"]], \"start\": [[88]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"MH\"]], \"start\": [[118]], \"entity_id\": [\"T4\"]}, \"Speculated\": {\"text\": [[\"possibly\"]], \"start\": [[101]], \"entity_id\": [\"T7\"], \"value\": true}}"
}
]
}
] |
12150593_1 | Neonatal mydriasis: intravenous lidocaine adverse reaction. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"adverse reaction\"]], \"start\": [[42]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"Neonatal mydriasis\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"lidocaine\"]], \"start\": [[32]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"lidocaine\"]], \"start\": [[32]], \"entity_id\": [\"T6\"]}}, \"Subject\": {\"text\": [[\"Neonatal\"]], \"start\": [[0]], \"entity_id\": [\"T7\"], \"Age\": {\"text\": [[\"Neonatal\"]], \"start\": [[0]], \"entity_id\": [\"T8\"]}}}"
}
]
}
] |
3417739_1 | Acute renal failure in a patient treated by continuous povidone-iodine mediastinal irrigation. | true | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"in\"]], \"start\": [[20]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Acute renal failure\"]], \"start\": [[0]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"a patient\"]], \"start\": [[23]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"continuous povidone-iodine mediastinal irrigation\"]], \"start\": [[44]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"povidone\"], [\"iodine\"]], \"start\": [[55], [64]], \"entity_id\": [\"T8\", \"T9\"]}, \"Route\": {\"text\": [[\"irrigation\"]], \"start\": [[83]], \"entity_id\": [\"T10\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"-\"]], \"start\": [[63]], \"entity_id\": [\"T11\"]}, \"Drug\": {\"text\": [[\"povidone\"], [\"iodine\"]], \"start\": [[55], [64]], \"entity_id\": [\"T8\", \"T9\"]}}]}}"
}
]
}
] |
7577414_2 | To our knowledge, this is the first case of griseofulvin-exacerbated lupus in which nephrotic syndrome has been observed. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"exacerbated\"]], \"start\": [[57]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"griseofulvin\"]], \"start\": [[44]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"griseofulvin\"]], \"start\": [[44]], \"entity_id\": [\"T9\"]}}, \"Effect\": {\"text\": [[\"lupus\", \"nephrotic syndrome\"]], \"start\": [[69, 84]], \"entity_id\": [\"T7\"]}, \"Subject\": {\"text\": [[\"the first case\"]], \"start\": [[26]], \"entity_id\": [\"T10\"]}, \"Speculated\": {\"text\": [[\"To our knowledge\"]], \"start\": [[0]], \"entity_id\": [\"T8\"], \"value\": true}}"
}
]
}
] |
12630660_6 | After reviewing the literature we suggest the CPM was a complication of lithium toxicity which affected the lateral geniculate nucleus which produced blindness. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"complication\"]], \"start\": [[56]], \"entity_id\": [\"T9\"]}, \"Effect\": {\"text\": [[\"CPM\", \"lithium toxicity\", \"blindness\"]], \"start\": [[46, 72, 150]], \"entity_id\": [\"T8\"]}, \"Treatment\": {\"text\": [[\"lithium\"]], \"start\": [[72]], \"entity_id\": [\"T10\"], \"Drug\": {\"text\": [[\"lithium\"]], \"start\": [[72]], \"entity_id\": [\"T11\"]}}, \"Speculated\": {\"text\": [[\"suggest\"]], \"start\": [[34]], \"entity_id\": [\"T7\"], \"value\": true}}"
}
]
}
] |
1267457_1 | A 71-year-old man, who had a history of a previous bullous drug reaction to a sulfonamide, began receiving an ophthalmic preparation that contained sulfacetamide sodium. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"reaction\"]], \"start\": [[64]], \"entity_id\": [\"T6\"]}, \"Subject\": {\"text\": [[\"A 71-year-old man\"]], \"start\": [[0]], \"entity_id\": [\"T3\"], \"Age\": {\"text\": [[\"71-year-old\"]], \"start\": [[2]], \"entity_id\": [\"T7\"]}, \"Gender\": {\"text\": [[\"man\"]], \"start\": [[14]], \"entity_id\": [\"T8\"]}}, \"Treatment\": {\"text\": [[\"sulfonamide\"]], \"start\": [[78]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"sulfonamide\"], [\"sulfacetamide sodium\"]], \"start\": [[78], [148]], \"entity_id\": [\"T9\", \"T10\"]}}, \"Effect\": {\"text\": [[\"bullous\"]], \"start\": [[51]], \"entity_id\": [\"T5\"]}}"
}
]
}
] |
9022114_4 | The authors report on two patients with corneal ulcers refractory to conventional treatment while the patients were undergoing oral colchicine therapy. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"undergoing\"]], \"start\": [[116]], \"entity_id\": [\"T4\"]}, \"Subject\": {\"text\": [[\"two patients\"]], \"start\": [[22]], \"entity_id\": [\"T3\"], \"Population\": {\"text\": [[\"two\"]], \"start\": [[22]], \"entity_id\": [\"T7\"]}}, \"Treatment\": {\"text\": [[\"oral colchicine therapy\"]], \"start\": [[127]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"colchicine\"]], \"start\": [[132]], \"entity_id\": [\"T8\"]}, \"Route\": {\"text\": [[\"oral\"]], \"start\": [[127]], \"entity_id\": [\"T9\"]}}, \"Effect\": {\"text\": [[\"corneal ulcers\"]], \"start\": [[40]], \"entity_id\": [\"T6\"]}}"
}
]
}
] |
2937155_3 | Vancomycin-induced vasculitis. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[11]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"Vancomycin\"]], \"start\": [[0]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"Vancomycin\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"vasculitis\"]], \"start\": [[19]], \"entity_id\": [\"T5\"]}}"
}
]
}
] |
8641617_2 | Based on our findings, it is thus concluded that cisplatin may cause C. difficile colitis. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"cause\"]], \"start\": [[63]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"cisplatin\"]], \"start\": [[49]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"cisplatin\"]], \"start\": [[49]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"C. difficile colitis\"]], \"start\": [[69]], \"entity_id\": [\"T5\"]}, \"Speculated\": {\"text\": [[\"may\"]], \"start\": [[59]], \"entity_id\": [\"T6\"], \"value\": true}}"
}
]
}
] |
7249424_2 | Nephrotic syndrome associated with lithium therapy. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[19]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Nephrotic syndrome\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"lithium therapy\"]], \"start\": [[35]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"lithium\"]], \"start\": [[35]], \"entity_id\": [\"T6\"]}}}"
}
]
}
] |
10728450_1 | We report 2 patients who developed polyarteritis nodosa following vaccination against hepatitis B. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[25]], \"entity_id\": [\"T4\"]}, \"Subject\": {\"text\": [[\"2 patients\"]], \"start\": [[10]], \"entity_id\": [\"T3\"], \"Population\": {\"text\": [[\"2\"]], \"start\": [[10]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"polyarteritis nodosa\"]], \"start\": [[35]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"vaccination against hepatitis B\"]], \"start\": [[66]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"vaccination against hepatitis B\"]], \"start\": [[66]], \"entity_id\": [\"T8\"]}}}"
}
]
}
] |
7594371_3 | We recommend the cautious use of ketorolac in patients with underlying illnesses where NSAID-induced ototoxicity could result in adverse otologic consequences. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"where\"]], \"start\": [[81]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"ketorolac\"]], \"start\": [[33]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"ketorolac\"]], \"start\": [[33]], \"entity_id\": [\"T9\"]}}, \"Subject\": {\"text\": [[\"patients with underlying illnesses\"]], \"start\": [[46]], \"entity_id\": [\"T4\"], \"Disorder\": {\"text\": [[\"underlying illnesses\"]], \"start\": [[60]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"NSAID-induced ototoxicity could result in adverse otologic consequences\"]], \"start\": [[87]], \"entity_id\": [\"T5\"]}, \"Speculated\": {\"text\": [[\"could\"]], \"start\": [[113]], \"entity_id\": [\"T8\"], \"value\": true}}"
}
]
}
] |
19660974_1 | Colitis as a manifestation of infliximab-associated disseminated cryptococcosis. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[41]], \"entity_id\": [\"T8\"]}, \"Effect\": {\"text\": [[\"Colitis\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"infliximab\"]], \"start\": [[30]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"infliximab\"]], \"start\": [[30]], \"entity_id\": [\"T9\"]}}}"
}
]
}
] |
8276031_2 | A 15-month-old girl with rhinopharyngitis was treated with a nasal solution containing the imidazoline derivative naphazoline. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Potential_therapeutic_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"treated\"]], \"start\": [[46]], \"entity_id\": [\"T7\"]}, \"Subject\": {\"text\": [[\"A 15-month-old girl with rhinopharyngitis\"]], \"start\": [[0]], \"entity_id\": [\"T6\"], \"Age\": {\"text\": [[\"15-month-old\"]], \"start\": [[2]], \"entity_id\": [\"T9\"]}, \"Gender\": {\"text\": [[\"girl\"]], \"start\": [[15]], \"entity_id\": [\"T10\"]}}, \"Treatment\": {\"text\": [[\"a nasal solution containing the imidazoline derivative naphazoline\"]], \"start\": [[59]], \"entity_id\": [\"T8\"], \"Disorder\": {\"text\": [[\"rhinopharyngitis\"]], \"start\": [[25]], \"entity_id\": [\"T11\"]}, \"Drug\": {\"text\": [[\"imidazoline derivative\"]], \"start\": [[91]], \"entity_id\": [\"T12\"]}, \"Route\": {\"text\": [[\"naphazoline\"]], \"start\": [[114]], \"entity_id\": [\"T13\"]}}}"
}
]
}
] |
9804082_1 | Three diabetic cases of acute dizziness due to initial administration of voglibose. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"due\"]], \"start\": [[40]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"Three diabetic cases\"]], \"start\": [[0]], \"entity_id\": [\"T3\"], \"Population\": {\"text\": [[\"Three\"]], \"start\": [[0]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"acute dizziness\"]], \"start\": [[24]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"initial administration of voglibose\"]], \"start\": [[47]], \"entity_id\": [\"T6\"], \"Drug\": {\"text\": [[\"voglibose\"]], \"start\": [[73]], \"entity_id\": [\"T9\"]}, \"Disorder\": {\"text\": [[\"diabetic\"]], \"start\": [[6]], \"entity_id\": [\"T10\"]}}}"
}
]
}
] |
14607011_1 | Fatal cold medication intoxication in an infant. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"in\"]], \"start\": [[35]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"Fatal cold medication intoxication\"]], \"start\": [[0]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"cold medication\"]], \"start\": [[6]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"cold medication\"]], \"start\": [[6]], \"entity_id\": [\"T11\"]}}, \"Subject\": {\"text\": [[\"infant\"]], \"start\": [[41]], \"entity_id\": [\"T8\"], \"Age\": {\"text\": [[\"infant\"]], \"start\": [[41]], \"entity_id\": [\"T9\"]}}}"
}
]
}
] |
7779233_1 | Case study: a modified topical treatment regimen for sodium warfarin-induced necrotizing fasciitis. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[69]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"sodium warfarin\"]], \"start\": [[53]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"sodium warfarin\"]], \"start\": [[53]], \"entity_id\": [\"T6\"]}}, \"Effect\": {\"text\": [[\"necrotizing fasciitis\"]], \"start\": [[77]], \"entity_id\": [\"T5\"]}}"
}
]
}
] |
16211208_2 | Marked QT prolongation and torsades de pointes secondary to acute ischemia in an elderly man taking dofetilide for atrial fibrillation: a cautionary tale. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"taking\"]], \"start\": [[93]], \"entity_id\": [\"T10\"]}, \"Treatment\": {\"text\": [[\"dofetilide\"]], \"start\": [[100]], \"entity_id\": [\"T7\"], \"Drug\": {\"text\": [[\"dofetilide\"]], \"start\": [[100]], \"entity_id\": [\"T14\"]}, \"Disorder\": {\"text\": [[\"atrial fibrillation\"]], \"start\": [[115]], \"entity_id\": [\"T15\"]}}, \"Subject\": {\"text\": [[\"an elderly man\"]], \"start\": [[78]], \"entity_id\": [\"T8\"], \"Age\": {\"text\": [[\"elderly\"]], \"start\": [[81]], \"entity_id\": [\"T11\"]}, \"Gender\": {\"text\": [[\"man\"]], \"start\": [[89]], \"entity_id\": [\"T12\"]}}, \"Effect\": {\"text\": [[\"Marked QT prolongation and torsades de pointes secondary to acute ischemia\"]], \"start\": [[0]], \"entity_id\": [\"T9\"]}}"
}
]
}
] |
18431096_1 | Methylphenidate and dextroamphetamine-induced peripheral vasculopathy. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[38]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"Methylphenidate and dextroamphetamine\"]], \"start\": [[0]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"dextroamphetamine\"], [\"Methylphenidate\"]], \"start\": [[20], [0]], \"entity_id\": [\"T7\", \"T8\"]}}, \"Effect\": {\"text\": [[\"peripheral vasculopathy\"]], \"start\": [[46]], \"entity_id\": [\"T6\"]}}"
}
]
}
] |
8969033_3 | The reversal of heparin by protamine may cause severe hemodynamic deterioration, characterized by systemic hypotension, pulmonary hypertension, and bronchoconstriction. | true | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"cause\"]], \"start\": [[41]], \"entity_id\": [\"T10\"]}, \"Effect\": {\"text\": [[\"severe hemodynamic deterioration\", \"systemic hypotension, pulmonary hypertension, and bronchoconstriction\"]], \"start\": [[47, 98]], \"entity_id\": [\"T9\"]}, \"Treatment\": {\"text\": [[\"The reversal of heparin by protamine\"]], \"start\": [[0]], \"entity_id\": [\"T12\"], \"Drug\": {\"text\": [[\"heparin\"], [\"protamine\"]], \"start\": [[16], [27]], \"entity_id\": [\"T16\", \"T17\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"reversal\"]], \"start\": [[4]], \"entity_id\": [\"T15\"]}, \"Drug\": {\"text\": [[\"heparin\"], [\"protamine\"]], \"start\": [[16], [27]], \"entity_id\": [\"T16\", \"T17\"]}}]}, \"Speculated\": {\"text\": [[\"may\"]], \"start\": [[37]], \"entity_id\": [\"T11\"], \"value\": true}}"
}
]
}
] |
19826099_1 | OBJECTIVE: To report a case of severe apnea in an infant exposed to lamotrigine through breast-feeding. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"in\"]], \"start\": [[44]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"severe apnea\"]], \"start\": [[31]], \"entity_id\": [\"T3\"]}, \"Subject\": {\"text\": [[\"an infant\"]], \"start\": [[47]], \"entity_id\": [\"T4\"], \"Age\": {\"text\": [[\"infant\"]], \"start\": [[50]], \"entity_id\": [\"T7\"]}}, \"Treatment\": {\"text\": [[\"exposed to lamotrigine through breast-feeding\"]], \"start\": [[57]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"lamotrigine\"]], \"start\": [[68]], \"entity_id\": [\"T8\"]}, \"Route\": {\"text\": [[\"breast-feeding\"]], \"start\": [[88]], \"entity_id\": [\"T9\"]}}, \"Severity\": {\"text\": [[\"severe\"]], \"start\": [[31]], \"entity_id\": [\"T10\"], \"value\": \"Medium\"}}"
}
]
}
] |
1316047_1 | Hemodynamic collapse following labetalol administration in preeclampsia. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"following\"]], \"start\": [[21]], \"entity_id\": [\"T6\"]}, \"Effect\": {\"text\": [[\"Hemodynamic collapse\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"labetalol\"]], \"start\": [[31]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"labetalol\"]], \"start\": [[31]], \"entity_id\": [\"T7\"]}, \"Disorder\": {\"text\": [[\"preeclampsia\"]], \"start\": [[59]], \"entity_id\": [\"T8\"]}}}"
}
]
}
] |
18801826_3 | We report a case of a 35-year old female who developed new onset type II diabetes mellitus with hyperosmolar hyperglycaemic coma and acute renal failure following treatment with a SGA for a first manic episode. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[45]], \"entity_id\": [\"T10\"]}, \"Subject\": {\"text\": [[\"35-year old female\"]], \"start\": [[22]], \"entity_id\": [\"T9\"], \"Age\": {\"text\": [[\"35-year old\"]], \"start\": [[22]], \"entity_id\": [\"T13\"]}, \"Gender\": {\"text\": [[\"female\"]], \"start\": [[34]], \"entity_id\": [\"T14\"]}}, \"Effect\": {\"text\": [[\"type II diabetes mellitus with hyperosmolar hyperglycaemic coma and acute renal failure\"]], \"start\": [[65]], \"entity_id\": [\"T11\"]}, \"Treatment\": {\"text\": [[\"treatment with a SGA\"]], \"start\": [[163]], \"entity_id\": [\"T12\"], \"Drug\": {\"text\": [[\"SGA\"]], \"start\": [[180]], \"entity_id\": [\"T15\"]}}}"
}
]
}
] |
8503421_3 | We report the occurrence of renal failure due to cholesterol crystal embolization following thrombolytic therapy with intravenous recombinant tissue-type plasminogen activator (t-PA). | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"occurrence\"]], \"start\": [[14]], \"entity_id\": [\"T7\"]}, \"Treatment\": {\"text\": [[\"thrombolytic therapy with intravenous recombinant tissue-type plasminogen activator (t-PA)\"]], \"start\": [[92]], \"entity_id\": [\"T9\"], \"Route\": {\"text\": [[\"intravenous\"]], \"start\": [[118]], \"entity_id\": [\"T10\"]}, \"Drug\": {\"text\": [[\"recombinant tissue-type plasminogen activator\"]], \"start\": [[130]], \"entity_id\": [\"T11\"]}}, \"Effect\": {\"text\": [[\"renal failure due to cholesterol crystal embolization\"]], \"start\": [[28]], \"entity_id\": [\"T8\"]}}"
}
]
}
] |
9161656_8 | The asthma resolved within 24 hours following three albuterol inhalations. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Potential_therapeutic_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"resolved\"]], \"start\": [[11]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"three albuterol inhalations\"]], \"start\": [[46]], \"entity_id\": [\"T6\"], \"Disorder\": {\"text\": [[\"asthma\"]], \"start\": [[4]], \"entity_id\": [\"T7\"]}, \"Dosage\": {\"text\": [[\"three\"]], \"start\": [[46]], \"entity_id\": [\"T8\"]}, \"Drug\": {\"text\": [[\"albuterol\"]], \"start\": [[52]], \"entity_id\": [\"T9\"]}, \"Time_elapsed\": {\"text\": [[\"within 24 hours\"]], \"start\": [[20]], \"entity_id\": [\"T10\"]}, \"Route\": {\"text\": [[\"inhalations\"]], \"start\": [[62]], \"entity_id\": [\"T4\"]}}}"
}
]
}
] |
2875665_2 | Administration of amantadine was associated with psychotic decompensations in two schizophrenic patients being maintained on concomitant neuroleptic medication. | true | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[33]], \"entity_id\": [\"T10\"]}, \"Treatment\": {\"text\": [[\"concomitant neuroleptic medication\", \"amantadine\"]], \"start\": [[125, 18]], \"entity_id\": [\"T9\"], \"Drug\": {\"text\": [[\"amantadine\"], [\"neuroleptic\"]], \"start\": [[18], [137]], \"entity_id\": [\"T15\", \"T16\"]}, \"Combination\": [{\"event_id\": \"E2\", \"event_type\": \"Combination\", \"Trigger\": {\"text\": [[\"concomitant\"]], \"start\": [[125]], \"entity_id\": [\"T17\"]}, \"Drug\": {\"text\": [[\"neuroleptic\"], [\"amantadine\"]], \"start\": [[137], [18]], \"entity_id\": [\"T16\", \"T15\"]}}]}, \"Effect\": {\"text\": [[\"psychotic decompensations\"]], \"start\": [[49]], \"entity_id\": [\"T11\"]}, \"Subject\": {\"text\": [[\"two schizophrenic patients\"]], \"start\": [[78]], \"entity_id\": [\"T12\"], \"Population\": {\"text\": [[\"two\"]], \"start\": [[78]], \"entity_id\": [\"T13\"]}, \"Disorder\": {\"text\": [[\"schizophrenic\"]], \"start\": [[82]], \"entity_id\": [\"T14\"]}}}"
}
]
}
] |
6998294_1 | Clinicians should be aware of fasting hypoglycemia as an unusual but potentially serious complication of disopyramide therapy. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"complication\"]], \"start\": [[89]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"disopyramide\"]], \"start\": [[105]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"disopyramide\"]], \"start\": [[105]], \"entity_id\": [\"T9\"]}}, \"Effect\": {\"text\": [[\"fasting hypoglycemia\"]], \"start\": [[30]], \"entity_id\": [\"T4\"]}, \"Speculated\": {\"text\": [[\"potentially\"]], \"start\": [[69]], \"entity_id\": [\"T7\"], \"value\": true}}"
}
]
}
] |
1569260_1 | To the best of our knowledge, this is the first reported patient with captopril-induced pemphigus in whom no new lesions developed after subsequent treatment with enalapril. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induced\"]], \"start\": [[80]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"captopril\"]], \"start\": [[70]], \"entity_id\": [\"T3\"], \"Drug\": {\"text\": [[\"captopril\"]], \"start\": [[70]], \"entity_id\": [\"T7\"]}}, \"Effect\": {\"text\": [[\"pemphigus\"]], \"start\": [[88]], \"entity_id\": [\"T5\"]}, \"Subject\": {\"text\": [[\"patient\"]], \"start\": [[57]], \"entity_id\": [\"T6\"]}}"
}
]
}
] |
9494448_5 | Fortunately, a hypersensitivity reaction to one formulation of cyclosporine does not preclude use of a different formulation. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"to\"]], \"start\": [[41]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"hypersensitivity reaction\"]], \"start\": [[15]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"one formulation of cyclosporine\"]], \"start\": [[44]], \"entity_id\": [\"T4\"], \"Drug\": {\"text\": [[\"cyclosporine\"]], \"start\": [[63]], \"entity_id\": [\"T6\"]}}}"
}
]
}
] |
11302479_1 | She developed a severe urticarial rash 3 weeks following initiation of therapy with Enoxaparin. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[4]], \"entity_id\": [\"T3\"]}, \"Effect\": {\"text\": [[\"urticarial rash\"]], \"start\": [[23]], \"entity_id\": [\"T4\"]}, \"Treatment\": {\"text\": [[\"Enoxaparin\"]], \"start\": [[84]], \"entity_id\": [\"T5\"], \"Time_elapsed\": {\"text\": [[\"3 weeks following\"]], \"start\": [[39]], \"entity_id\": [\"T6\"]}, \"Drug\": {\"text\": [[\"Enoxaparin\"]], \"start\": [[84]], \"entity_id\": [\"T7\"]}}, \"Severity\": {\"text\": [[\"severe\"]], \"start\": [[16]], \"entity_id\": [\"T8\"], \"value\": \"High\"}}"
}
]
}
] |
9545161_3 | Fatal toxic epidermal necrolysis related to lamotrigine administration. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"related to\"]], \"start\": [[33]], \"entity_id\": [\"T4\"]}, \"Effect\": {\"text\": [[\"Fatal toxic epidermal necrolysis\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Treatment\": {\"text\": [[\"lamotrigine administration\"]], \"start\": [[44]], \"entity_id\": [\"T5\"], \"Drug\": {\"text\": [[\"lamotrigine\"]], \"start\": [[44]], \"entity_id\": [\"T7\"]}}, \"Severity\": {\"text\": [[\"Fatal\"]], \"start\": [[0]], \"entity_id\": [\"T6\"], \"value\": \"Medium\"}}"
}
]
}
] |
11918514_3 | OBJECTIVE: To document a case of serotonin syndrome (SS) associated with mirtazapine monotherapy, review the previously reported cases of SS associated with this tetracyclic antidepressant, and discuss the possible pathogenic mechanisms leading to this serious adverse drug reaction. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"associated\"]], \"start\": [[57]], \"entity_id\": [\"T7\"]}, \"Subject\": {\"text\": [[\"a case\"]], \"start\": [[23]], \"entity_id\": [\"T5\"]}, \"Effect\": {\"text\": [[\"serotonin syndrome (SS)\"]], \"start\": [[33]], \"entity_id\": [\"T6\"]}, \"Treatment\": {\"text\": [[\"mirtazapine monotherapy\"]], \"start\": [[73]], \"entity_id\": [\"T8\"], \"Drug\": {\"text\": [[\"mirtazapine\"]], \"start\": [[73]], \"entity_id\": [\"T9\"]}}}"
}
]
}
] |
15331204_6 | CONCLUSION: Therapy with indapamide may induce diabetes in essential hypertension patients. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"induce\"]], \"start\": [[40]], \"entity_id\": [\"T10\"]}, \"Effect\": {\"text\": [[\"diabetes\"]], \"start\": [[47]], \"entity_id\": [\"T8\"]}, \"Treatment\": {\"text\": [[\"indapamide\"]], \"start\": [[25]], \"entity_id\": [\"T9\"], \"Drug\": {\"text\": [[\"indapamide\"]], \"start\": [[25]], \"entity_id\": [\"T14\"]}, \"Disorder\": {\"text\": [[\"essential hypertension\"]], \"start\": [[59]], \"entity_id\": [\"T15\"]}}, \"Subject\": {\"text\": [[\"essential hypertension patients\"]], \"start\": [[59]], \"entity_id\": [\"T11\"]}, \"Speculated\": {\"text\": [[\"may\"]], \"start\": [[36]], \"entity_id\": [\"T13\"], \"value\": true}}"
}
]
}
] |
11033836_2 | Placebo-controlled clinical trials of recombinant human interleukin-11 (rhIL-11, also known as oprelvekin [Neumega]) in patients with nonmyeloid malignancies have demonstrated significant efficacy in preventing postchemotherapy platelet nadirs of < or = 20,000/microL, and reducing the need for platelet transfusions while continuing chemotherapy without dose reductions. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Potential_therapeutic_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Potential_therapeutic_event\", \"Trigger\": {\"text\": [[\"preventing\"]], \"start\": [[200]], \"entity_id\": [\"T15\"]}, \"Subject\": {\"text\": [[\"patients with nonmyeloid malignancies\"]], \"start\": [[120]], \"entity_id\": [\"T12\"], \"Disorder\": {\"text\": [[\"nonmyeloid malignancies\"]], \"start\": [[134]], \"entity_id\": [\"T17\"]}}, \"Treatment\": {\"text\": [[\"recombinant human interleukin-11 (rhIL-11, also known as oprelvekin [Neumega])\"]], \"start\": [[38]], \"entity_id\": [\"T11\"], \"Disorder\": {\"text\": [[\"postchemotherapy platelet nadirs of < or = 20,000/microL\"]], \"start\": [[211]], \"entity_id\": [\"T16\"]}, \"Drug\": {\"text\": [[\"recombinant human interleukin-11\"]], \"start\": [[38]], \"entity_id\": [\"T13\"]}}}"
}
]
}
] |
115078_1 | A patient with rheumatoid arthritis developed an acute intrahepatic cholestasis after 100 mg of sodium aurothiomalate. | false | [
{
"events": [
{
"event_id": "E1",
"event_type": "Adverse_event",
"event_data": "{\"event_id\": \"E1\", \"event_type\": \"Adverse_event\", \"Trigger\": {\"text\": [[\"developed\"]], \"start\": [[36]], \"entity_id\": [\"T7\"]}, \"Subject\": {\"text\": [[\"A patient with rheumatoid arthritis\"]], \"start\": [[0]], \"entity_id\": [\"T3\"]}, \"Effect\": {\"text\": [[\"acute intrahepatic cholestasis\"]], \"start\": [[49]], \"entity_id\": [\"T5\"]}, \"Treatment\": {\"text\": [[\"100 mg of sodium aurothiomalate\"]], \"start\": [[86]], \"entity_id\": [\"T8\"], \"Disorder\": {\"text\": [[\"rheumatoid arthritis\"]], \"start\": [[15]], \"entity_id\": [\"T4\"]}, \"Dosage\": {\"text\": [[\"100 mg\"]], \"start\": [[86]], \"entity_id\": [\"T10\"]}, \"Drug\": {\"text\": [[\"sodium aurothiomalate\"]], \"start\": [[96]], \"entity_id\": [\"T11\"]}}}"
}
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}
] |