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CONCLUSIONS In subjects with mild hypertension calcitonin gene-related peptide is sensitive to changes in salt intake in the physiological range . |
CONCLUSIONS Such a response seems to be linked to the individual arterial pressure response to salt , because salt-resistant patients showed reduced calcitonin gene-related peptide levels in the sodium-replete state and a more pronounced calcitonin gene-related peptide increase , closely related to plasma renin activity , during sodium deprivation . |
###19777852 |
OBJECTIVE To make a study of the effect of Chaihu Shihuang soup on blood serum level TNF , IL-6 and IL-10 of severe acute pancratitis . |
METHODS Sixty SAP cases were divided at random into treatment group and control group ( 30 cases each ) . |
METHODS The treatment group were given chai-hu-shi-huang-soup once a day ; the control group were given Dachaihu soup once daily , with both treatment period for 7 days . |
METHODS The tumor necrosis factor-alpha ( TNF-alpha ) , interleukin level 6 ( IL-6 ) and 10 ( IL-10 ) of both groups were determined before and after the treatment . |
METHODS We also had 30 healthy cases . |
RESULTS IL-10 level in both groups was lower than healthy group while TNF-alpha and IL-6 were higher than healthy group ( P < 0.01 ) . |
RESULTS After treatment , the treatment group 's TNF-alpha , IL-6 level were comparatively lower than that in the control group ( P < 0.01 ) , and IL-10 level were clearly higher than that of the control group ( P < 0.01 ) , comparison of the treatment group before treatment ( P < 0.01 ) . |
CONCLUSIONS Chaihu Shihuang soup can significantly regulate cytokine and improve early recovery of SAP . |
###24361227 |
BACKGROUND Paclitaxel and gemcitabine ( PG ) combination chemotherapy is effective as a maintenance chemotherapeutic regimen in metastatic breast cancer ( MBC ) patients because it increases progression-free survival ( PFS ) , which increases overall survival ( OS ) . |
BACKGROUND The primary purpose of our study was to investigate the association between genetic polymorphisms in the genes involved in PG pathways and clinical outcomes in MBC patients treated with PG chemotherapy . |
METHODS A total of 324 MBC patients were enrolled in this prospective multicenter trial of PG as the first-line chemotherapy . |
METHODS Eighty-five of the 324 patients from two institutes were available for analysis of single nucleotide polymorphisms ( SNPs ) . |
METHODS Germline DNA was extracted from peripheral blood mononuclear cells . |
METHODS Thirty-eight SNPs in 15 candidate genes selected from pathways that may influence the metabolism and transport of , or sensitivity , to PG were analysed . |
RESULTS The median PFS and OS of all 324 patients were 8.7 months ( 95 % confidence interval [ CI ] : 7.5-9 .6 months ) and 26.9 months ( 95 % CI : 23.6-30 .1 months ) , respectively . |
RESULTS An SNP in SLC28A3 ( rs7867504 , C/T ) was associated with OS ( CC or CT versus TT : 37 versus 21 months , p = 0.027 , hazard ratio [ HR ] 2.6 , 95 % CI : 1.1-6 .3 ) . |
RESULTS SLC29A1 GA haplotype had a significantly shorter OS ( p = 0.030 , HR 3.391 , 95 % CI : 1.13-10 .19 ) . |
RESULTS RRM1 ( ribonucleotide reductase large subunit M1 ) SNP ( rs9937 ) , and haplotypes ATAA and ATGA were significantly associated with neurotoxicity . |
CONCLUSIONS Genetic polymorphisms in SLC28A3 , SLC29A1 and RRM1 can influence the clinical outcome of MBC patients treated with PG chemotherapy . |
CONCLUSIONS Further studies on the functional mechanisms relating to these germline polymorphisms in these genes are warranted . |
###23460711 |
OBJECTIVE Elderly patients form a heterogeneous population . |
OBJECTIVE Evaluation of geriatric factors may help evaluate a patient 's health status to better adapt treatment . |
METHODS Elderly patients with previously untreated metastatic colorectal cancer ( mCRC ) were randomly assigned to receive fluorouracil ( FU ) - based chemotherapy either alone or in combination with irinotecan ( IRI ) in the Fdration Francophone de Cancrologie Digestive ( FFCD ) 2001-02 study . |
METHODS Sites participating in the geriatric substudy completed geriatric screening tools to perform prognostic factor analyses for treatment safety during the first 4 months after treatment initiation . |
RESULTS The geriatric score was calculated in 123 patients ( 44 % ) . |
RESULTS Median age was 80 years ( range , 75 to 91 years ) . |
RESULTS The Charlson comorbidity index was 1 in 75 % , Mini-Mental State Examination ( MMSE ) score was 27/30 in 31 % , and Instrumental Activities of Daily Living ( IADL ) showed impairment in 34 % of the patients . |
RESULTS Seventy-one patients ( 58 % ) had grade 3 to 4 toxicity , 41 ( 33 % ) had a dose-intensity reduction of more than 33 % , and 54 ( 44 % ) had at least one unexpected hospitalization during the first 4 months after starting treatment . |
RESULTS In multivariate analysis , significant predictive factors for grade 3-4 toxicity were IRI arm ( odds ratio [ OR ] , 5.03 ) , MMSE 27/30 ( OR , 3.84 ) , and impaired IADL ( OR , 4.67 ) ; for dose-intensity reduction of > 33 % , the significant predictive factors were alkaline phosphates > 2 upper limit of normal ( OR , 4.16 ) and IRI arm ( OR , 6.85 ) ; and for unexpected hospitalization , significant predictive factors were MMSE 27/30 ( OR , 4.56 ) and Geriatric Depression Scale 2 ( OR , 5.52 ) . |
CONCLUSIONS Geriatric factors ( MMSE and IADL ) are predictive of severe toxicity or unexpected hospitalization ( MMSE ) in a randomized prospective phase III study in mCRC . |
CONCLUSIONS These results suggest that cognitive function and autonomy impairment should be taken into account when choosing a regimen for chemotherapy . |
###1905621 |
OBJECTIVE To study the effect of aldose reductase inhibition with ponalrestat on resistance to ischemic conduction block ( RICB ) in diabetic subjects . |
METHODS Twenty-one healthy diabetic subjects without neuropathy were studied . |
METHODS Subjects were randomized to take either a double-blind trial of 600 mg ponalrestat or placebo once daily for 6 wk . |
METHODS The median nerve action potential ( MNAP ) and conduction velocity ( NCV ) , before and after 20 min of forearm ischemia , were measured at the start and finish of the study . |
RESULTS RICB ( MNAP remaining after ischemia ) decreased from 39.5 to 29.4 % in the ponalrestat-treated group ( P less than 0.05 ) and increased from 48.1 + / - 10.2 to 49.5 + / - 6.5 % in the placebo-treated group . |
RESULTS MNAP and NCV were unchanged in both groups . |
CONCLUSIONS Aldose reductase inhibition with ponalrestat partly reverses RICB in diabetes , perhaps by improving nerve hypoxia or reducing nerve energy substrates . |
###23967878 |
BACKGROUND Pain is a common symptom of chronic fatigue syndrome ( CFS ) . |
BACKGROUND We investigated the effects of the treatments used in the PACE trial [ cognitive behavioural therapy ( CBT ) , graded exercise therapy ( GET ) , adaptive pacing therapy ( APT ) and specialist medical care ( SMC ) ] on pain in CFS . |
METHODS We compared pain outcomes including individual painful symptoms , taken from the CDC criteria for CFS and co-morbid fibromyalgia . |
METHODS We modelled outcomes adjusting for baseline variables with multiple linear regression . |
RESULTS Significantly less frequent muscle pain was reported by patients following treatment with CBT compared to SMC ( mean difference = 0.38 unit change in frequency , p = 0.02 ) , GET versus SMC ( 0.42 , p = 0.01 ) and GET versus APT ( 0.37 , p = 0.01 ) . |
RESULTS Significantly less joint pain was reported following CBT versus APT ( 0.35 , p = 0.02 ) and GET versus APT ( 0.36 , p = 0.02 ) . |
RESULTS Co-morbid fibromyalgia was less frequent following GET versus SMC ( 0.03 , p = 0.03 ) . |
RESULTS The effect sizes of these differences varied between 0.25 and 0.31 for muscle pain and 0.24 and 0.26 for joint pain . |
RESULTS Treatment effects on pain were independent of ` change in fatigue ' . |
CONCLUSIONS CBT and GET were more effective in reducing the frequency of both muscle and joint pain than APT and SMC . |
CONCLUSIONS When compared to SMC , GET also reduced the frequency of co-morbid fibromyalgia ; the size of this effect on pain was small . |
###25833972 |
BACKGROUND Poor nutritional quality of complementary foods often limits growth . |
BACKGROUND Animal source foods , such as milk or meat , are often unaffordable . |
BACKGROUND Local affordable alternatives are needed . |
OBJECTIVE We evaluate the efficacy of 2 newly developed , rice-based complementary food products : WinFood ( WF ) with small fish and edible spiders and WinFood-Lite ( WF-L ) fortified with small fish , against 2 existing fortified corn-soy blend products , CSB + ( purely plant based ) and CSB + + ( 8 % dried skimmed milk ) . |
METHODS In total , 419 infants aged 6 mo were enrolled in this randomized , single-blinded study for 9 mo , designed primarily to assess increments in fat-free mass by a deuterium dilution technique and change in plasma ferritin and soluble transferrin receptor . |
METHODS Secondary endpoints were changes in anthropometric variables , including knee-heel length . |
METHODS Data were analyzed by the intention-to-treat approach . |
RESULTS There was no difference in fat-free mass increment in WF or WF-L compared with CSB + [ WF : +0.04 kg ( 95 % CI : -0.20 , 0.28 kg ) ; WF-L : +0.14 kg ( 95 % CI : -0.10 , 0.38 kg ) ] or CSB + + [ WF : -0.03 kg ( 95 % CI : -0.27 , 0.21 kg ) ; WF-L : +0.07 kg ( 95 % CI : -0.18 , 0.31 kg ) ] and no effect on iron status . |
RESULTS The 1.7-mm ( 95 % CI : -0.1 , 3.5 mm ) greater increase in knee-heel length in WF-L than in CSB + was not significant . |
CONCLUSIONS No difference was found between the locally produced products ( WF and WF-L ) and the CSBs . |
CONCLUSIONS Micronutrient fortification may be necessary , and small fish may be an affordable alternative to milk to improve complementary foods . |
CONCLUSIONS The dietary role of edible spiders needs to be further explored . |
CONCLUSIONS This trial was registered at controlled-trials . |
CONCLUSIONS com as ISRCTN19918531 . |
###24184063 |
OBJECTIVE This study investigated the effect of contingent electrical stimulation ( CES ) on present pain intensity ( PI ) , pressure pain threshold ( PPT ) , and electromyographic events per hour of sleep ( EMG/h ) on probable bruxers with masticatory myofascial pain . |
METHODS The study enrolled 15 probable bruxers with masticatory myofascial pain in 3 phases : ( 1 ) baseline EMG/h recording , ( 2 ) biofeedback treatment using a CES paradigm ( active group , n = 7 ) or inactive device ( control group , n = 8 ) , and ( 3 ) posttreatment EMG/h recording . |
METHODS PI and PPT were assessed after each phase . |
METHODS Analysis of variance models were used to compare results at a 5 % significance level . |
RESULTS Patients in the active group had 35 % lower EMG/h in P2 and 38.4 % lower EMG/h in P3 , when compared with baseline . |
RESULTS There were no differences in PI or PPT levels at any phase . |
CONCLUSIONS CES could reduce EMG activity associated with sleep bruxism in patients with masticatory myofascial pain but did not influence perceived pain . |
###21742094 |
BACKGROUND Mortality after ST-elevation myocardial infarction ( STEMI ) has reduced with reperfusion by primary percutaneous coronary intervention ( PCI ) , which may have impacted on the adverse outcomes of cardiogenic shock ( CS ) and congestive heart failure ( CHF ) . |
RESULTS In the APEX-AMI trial , 5,745 patients with STEMI and planned primary PCI were randomly assigned pexelizumab or matching placebo . |
RESULTS Post-randomization CS or CHF was adjudicated by a clinical endpoints committee . |
RESULTS Treatment assignment to pexelizumab did not influence either endpoint or mortality rates . |
RESULTS Cardiogenic shock developed in 196 patients ( 3.4 % ) at a median of 6.0 hours ( interquartile range 3.9-28 .3 ) post-randomization , and mortality at 90 days was 54.6 % . |
RESULTS Congestive heart failure occurred in 254 of patients ( 4.4 % ) at a median of 2.6 days ( IQR 1.0-16 .6 ) , and mortality through 90 days was 10.2 % ; mortality among those with neither endpoint was 2.1 % . |
RESULTS Patients with CS or CHF were older , were more often female , and had more hypertension and diabetes , but smoked less compared with non-CS/CHF patients ( all P < .05 ) . |
RESULTS Independent mortality predictors among those with CS or CHF were hyperlipidemia and a history of angina ( interaction P = .011 and .008 , respectively ) ; procedural predictors among survivors to PCI were pre-PCI Thrombolysis In Myocardial Infarction ( TIMI ) flow 0-1 and post-PCI TIMI flow < 3 ( P = .013 and < .0001 , respectively ) . |
CONCLUSIONS Survival after CS remains poor despite aggressive reperfusion . |
CONCLUSIONS Both CS and CHF remain the major causes of death among STEMI patients undergoing primary PCI . |
CONCLUSIONS Future studies should examine treatments that aim to reduce mortality in these highest risk patients . |