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Which biomarkers are currently used for Duchenne Muscular Dystrophy?

MRI measurements can be used as biomarkers of disease severity in ambulant patients with DMD. malate dehydrogenase 2 as candidate prognostic biomarker for Duchenne muscular dystrophy

What tissue is commonly affected in Marfan's syndrome

Marfan syndrome (MS) is a connective tissue disorder that affects thousands of adolescents

Rachmilewitz Index is used for which diseases?

Rachmilewitz Index is used for assessment of endoscopic disease activity of patients with ulcerative colitis.

What is the basis of the methidiumpropyl-EDTA sequencing (MPE-seq) method?

MPE-seq (methidiumpropyl-EDTA sequencing) is a new method for the genome-wide characterization of chromatin that involves the digestion of nuclei with MPE-Fe(II) followed by massively parallel sequencing of the whole genome. Like micrococcal nuclease (MNase), MNase preferentially cleaves the linker DNA between nucleosomes. However, there are differences in the cleavage of nuclear chromatin by MP e-seq relative to MNase. Moreover, unlike MNase, MPe-seq cleaves nuclear DNA

What is the reason for the abundance of operons in the genome of C. elegans?

Our data shows that transcription proceeds in some ways as if operons were composed of multiple adjacent single genes. Recent hypothesis proposes that operons provide an evolutionary advantage via the conservation of machinery during recovery from growth arrested states.

What is MULTOVL?

MULTOVL is an application suite that detects and statistically analyses multiple overlaps of genomic regions in a fast and efficient manner. The package supports the detection of multiple region intersections, unions and 'solitary' genomic regions. The significance of actually observed overlaps is estimated by comparing them with empirical null distributions generated by random shuffling of the input regions.

What are the uber-operons?

Uber-operons are groups of functionally or transcriptionally related operons, whose gene sets are conserved across multiple reference genomes. Many of the uber-operons correspond to parts of known regulons or biological pathways or are involved in highly related biological processes based on their Gene Ontology (GO) assignments.

What is the effect of SAHA treatment in Huntington's disease?

Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, protects dopaminergic neurons from neurotoxin-induced damage. SAHA is predominantly an inhibitor of class I HDACs. However, it can also bind to class IIa HDACs and has been shown to degrade class IIa HDACs at the protein level in vitro. The neuroprotective effects of SAHA were mediated in part by promoting release of neurotrophic factors from astroglia through inhibition of histone deacetylation. SAHA can lead to the degradation of class IIa HDACs 4 and 5 via RANBP2 mediated proteasome degradation in vitro.

Are breaks in double stranded DNA associated with ionizing radiation?

Yes, double-strand breaks in double stranded DNA may be associated with ionizing radiation risk.

Is SARS virus interacting with ACE2 encoded protein?

Yes, The infection of target cells by the SARS CoV is mediated through the interaction of the viral Spike (S) protein (1255 amino acids) and its cellular receptor, angiotensin-converting enzyme 2 (ACE2).

What is the indication of Daonil (Glibenclamide)?

Glibenclamide is an antidiabetic and antiglycemic, used in severe NIDDM, and increasingly viewed as a rational alternative to insulin therapy.

Mutation of which gene is implicated in the Brain-lung-thyroid syndrome?

Brain-lung-thyroid syndrome (BLTS) characterized by congenital hypothyroidism, respiratory distress syndrome, and benign hereditary chorea is caused by thyroid transcription factor 1 (NKX2-1/TTF1) mutations.

Which agents are included in the FLAMSA chemotherapy regimen?

Fludarabine, cytarabine and amsacrine are included in the FLAMSA chemotherapy regimen.

Is Pfh1 a component of the replisome?

No. Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity. DNA replication through hard-to-replicate sites, including both highly transcribed RNA Pol II and Pol III genes, requires the S. pombe Pfh1 helicase.

List the two most important synaptic markers.

postsynaptic density 95 synaptophysin

Which types of cancer can be recognized and treated by the use of immunotherapy?

When normal cells turn into cancer cells, some of the antigens on their surface change. These cells, like many body cells, constantly shed bits of protein from their surface into the circulatory system. Often, tumor antigens are among the shed proteins. These shed antigens prompt action from immune defenders, including cytotoxic T cells, natural killer cells, and macrophages. According to one theory, patrolling cells of the immune system provide continuous bodywide surveillance, catching and eliminating cells that undergo malignant transformation. Tumors develop when this immune surveillance breaks down or is overwhelmed. A new approach to cancer therapy uses antibodies that have been specially made to recognize specific cancers such as Melanoma, Leukaemia, Lung Cancer, Colorectal Cancer, Breast Cancer, Head Cancer and Pancreatic Cancer.

What is the content of the REPAIRtoire database?

The REPAIRtoire database collects and organizes the following types of information: (i) DNA damage linked to environmental mutagenic and cytotoxic agents, (ii) pathways comprising individual processes and enzymatic reactions involved in the removal of damage, (iii) proteins participating in DNA repair and (iv) diseases correlated with mutations in genes encoding DNA repair proteins. REPAIRtoire provides also links to publications and external databases.

What is the COUGER tool?

COUGER takes as input two sets of genomic regions bound by paralogous TFs, and it identifies a small set of putative co-factors that best distinguish the two sets of sequences.

Which SLC family is FLVCR1 a member of?

Feline leukemia virus subgroup C receptor (FLVCR1) is a member of the SLC49 family.

Which are the predominant rotavirus genotypes around the world?

The predominant RV genotypes circulating all over the world are G1P[8], G2P[4], G3P[8], G4P[8], and G9P[8], while G12[P6] and G12[P8] are emerging genotypes.

What animal is thought to be the host for the Coronavirus causing MERS?

The animal thought to be the host for the Coronavirus causing MERS is camels.

Which genes are more frequently affected by somatic mutations in Chronic Lymphocytic Leukemia

TP53, ATM, NOTCH1, XPO1, MYD88, KLHL6, SF3B1, ZMYM3, MAPK1, FBXW7 and DDX3X

Does gavestinel improve outcomes of stroke patients?

No. In a randomized clinical trial, treatment with gavestinel within 6 hours of acute ischaemic stroke did not improve outcome.

What is the genus for the common European honey bee?

The genus and species of the European honey bee is Apis mellifera.

What is Telangiectasia?

Telangiectasia (macroscopically visible dilated skin vessels)

In which yeast chromosome does the rDNA cluster reside?

Chromosome XII context is important for rDNA function in yeast

Is the FIP virus thought to be a mutated strain for the Feline enteric Coronavirus?

yes, Feline infectious peritonitis (FIP) results from mutations in the viral genome during a common feline enteric coronavirus (FECV) infection.

What is the effect of Satb1 knock-out in mice?

inhibited cell viability and migration

Are selenium supplements recommended for prostate cancer prevention?

No. The SELECT study failed to show any significant risk reduction for prostate cancers ascribable to selenium and vitamin E supplementations.

Is aganglionic megacolon a feature of Down syndrome?

Down syndrome (DS) is recognized by characteristic facial features, intellectual disability, and an increased risk for cardiac malformations and duodenal atresia. Recently, Hirschsprung disease (HSCR), or congenital aganglionic megacolon, has been seen more often among patients with DS.

Is there a genetic cause of craniostenosis?

9There a a number of different genetic mutations or syndromes(Saethre-Chotzen, Aperts, Crouzon, Pfeiffer) associated with craniostenosis.

What is NTI, Nerve Tissue Contrast Index

The Nerve Tissue Index NTI is a ratio of average brightness levels of surrounding tissue and the median nerve, both calculated on the basis of a ultrasound image.

What is CIBERSORT used for?

CIBERSORT is a versatile computational method for characterizing cell composition of complex tissues from their gene expression profiles.

What is the CEGA catalog?

CEGA is a catalog of conserved elements from genomic alignments. Harnessing the power of multiple species comparisons to detect genomic elements under purifying selection, CEGA provides a comprehensive set of CNCs identified at different radiations along the vertebrate lineage. Evolutionary constraint is identified using threshold-free phylogenetic modeling of unbiased and sensitive global alignments of genomic synteny blocks identified using protein orthology. The dynamic CEGA web interface displays alignments, genomic locations, as well as biologically relevant data to help prioritize and select CNCs of interest for further functional investigations.

Down's syndrome occurs when an individual has an extra copy or part of a copy of chromosome 21, yes or no?

Yes, Downs syndrome is caused by a duplication or all or part of chromosome 21.

Is celecoxib effective for amyotrophic lateral sclerosis?

No. In a clinical trial, celecoxib did not have a beneficial effect on patients with amyotrophic lateral sclerosis.

What is the Timothy syndrome?

Timothy syndrome is a multisystem disorder characterized by cardiac, hand/foot, facial, and neurodevelopmental features. The two forms are type 1 (classic) and type 2, a rare form caused by mutations in a transcript variant of the same gene. Cardiac findings include a rate-corrected QT interval of between 480 ms and 700 ms and congenital heart defects (patent ductus arteriosus, patent foramen ovale, ventricular septal defect, tetralogy of Fallot, hypertrophic cardiomyopathy). Hand/foot findings are unilateral or bilateral cutaneous syndactyly variably involving fingers two (index), three (middle), four (ring), and five (little) and bilateral cutaneous syndactyly of toes two and three. Facial findings include flat nasal bridge, low-set ears, thin upper lip, and round face. Neuropsychiatric involvement includes global developmental delays and autism spectrum disorders. Ventricular tachyarrhythmia is the leading cause of death, followed by infection and complications of intractable hypoglycemia. Average age of death is 2.5 years.

What is the purpose of the Ottawa Ankle Rule?

Ottawa Ankle Rules is a clinical decision tool used to minimize unnecessary radiographs in ankle and foot injuries. It shows the areas of tenderness to be evaluated in ankle trauma patients to determine the need for imaging.

Are Notch mutations related to T-cell Acute Lymphoblastic Leukemia (T-ALL)?

Notch1 is a transmembrane receptor that is frequently mutated in human T-cell acute lymphoblastic leukemia (T-ALL). Activating mutations in NOTCH1, an essential regulator of T cell development, are frequently found in human T cell acute lymphoblastic leukemia (T-ALL).

Are reduced-nicotine cigarettes effective for smoking cessation?

Yes, reduced-nicotine cigarettes are effective for smoking cessation.

What is magnetoreception?

Magnetoreception is an enigmatic, poorly understood sensory ability, described mainly on the basis of behavioural studies in animals of diverse taxa. The ability to perceive geomagnetic fields (GMFs) represents a fascinating biological phenomenon. Studies on transgenic flies have provided evidence that photosensitive Cryptochromes (Cry) are involved in the response to magnetic fields (MFs). The photoreceptor protein cryptochrome is thought to host, upon light absorption, a radical pair that is sensitive to very weak magnetic fields, endowing migratory birds with a magnetic compass sense.

Has Glucose-6-phosphate dehydrogenase (G6PD) deficiency an X-linked inheritance?

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the commonest red cell enzymopathy in humans and has an X-linked inheritance.

Does low T3 negatively affect prognosis of patients after cardiac surgery?

Low cardiac output syndrome after cardiac surgery for congenital heart diseases is associated with decreased T3 Low T3 concentrations are associated with occurrence of post operative atrial fibrillation Low T3 concentrations are inversely correlated with the days of post operative hospitalization

Have mutations in the GARS gene been identified to cause Charcot-Marie-Tooth Disease Type 2D (CMT2D)?

Charcot-Marie-Tooth disease type 2D (CMT2D) is caused by missense mutations in the glycyl-tRNA synthetase gene (GARS).

What virus is the Gardisil vaccine used for?

Gardisil is a quadrivalent HPV vaccine would have been useful in the prevention of infections with human papillomavirus.

List cohesinopathies

Roberts syndrome (RBS), Cornelia de Lange Syndrome (CdLS), Warsaw Breakage Syndrome (WABS) and Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome.

What is the purpose of the LINCS Project?

The Library of Integrated Network-Based Cellular Signatures (LINCS) project aims to create a network-based understanding of biology by cataloging changes in gene expression and signal transduction that occur when cells are exposed to a variety of perturbations.

Which gene is associated with Muenke syndrome?

Muenke syndrome has been related to a mutation on the Fibroblast Growth Factor Receptor (FGFR3) gene.

What is the ubiquitin proteome?

The ubiquitin proteome is the entire set ubiquitinated proteins and of their respective ubiquitination sites.

Are there negative enhancers?

Yes, negative enhancers are also called gene silencers.

Which myosin isozymes are located within the pericuticular necklace of the hair cell?

The hair cell is located in the inner ear, a tissue that is particularly reliant on actin-rich structures and unconventional myosin isozymes. Within the pericuticular necklace, a domain of the hair cell, certain unconventional myosin isozymes are located, namely myosins-Ibeta, myosin-VI, and myosin-VIIa.

What is the systemic nickel allergy syndrome?

A severe form of this allergy is the Systemic nickel allergy syndrome, clinically characterized by cutaneous manifestions (contact dermatitis, pompholyx, hand dermatitis dyshydrosis, urticaria) with chronic course and systemic symptoms (headache, asthenia, itching, and gastrointestinal disorders related to histopathological alterations of gastrointestinal mucosa, borderline with celiac disease).

Which cell types are known to be driving Rheumatoid Arthritis?

Macrophages, T cells and their respective cytokines play a pivotal role in RA. Rheumatoid arthritis synovial fibroblasts (RASFs) constitute a quite unique cell type that distinguishes RA from other inflammatory conditions of the joints. Activated synovial fibroblasts (SFs) have the ability to invade joint cartilage, actively contributing to joint destruction in RA.

Is Obeticholic Acid used for treatment of Primary Biliary Cholangitis?

Yes, obeticholic acid is a farnesoid-X receptor agonist that is approved for the treatment of primary biliary cholangitis in combination with ursodeoxycholic acid in adults with an inadequate response to ursodeoxycholic acid, or as monotherapy in adults unable to tolerate ursodeoxycholic acid.

Which deficiency is the cause of restless leg syndrome?

It has been well-documented that iron deficiency is the cause of restless leg syndrome. Magnesium and ferritin were also associated with restless leg syndrome.

What is the result of the interaction between TSC1 and PLK1?

Phosphorylated TSC1 (hamartin) interacts with Plk1 independent of TSC2 (tuberin), with all three proteins present in a complex, and negatively regulates the protein levels of Plk1, to control centrosome duplication.

Is the TFR1 gene dispensable for erythropoiesis?

Yes. The TFR1 gene is a key part of the mechanism by which the body delivers iron to the red blood cells. It is not dispensable for erythropoiesis.

Which genes are the main markers of primitive Endoderm (prEN) formation?

The genes involved in primitive endoderm (prEN) formation are fgf4, lrp2, gata4, pdgfra, p dgfrα, gATA6, nanog, pDgfralpha, egam1 and dab2.

Which is the main calcium binding protein of the sarcoplasmic reticulum?

Calsequestrin is the major calcium-binding protein of cardiac and skeletal muscles whose function is to sequester Ca(2+ )in the lumen of the sarcoplasmic reticulum (SR).

What type of enzyme is peroxiredoxin 2 (PRDX2)?

Peroxiredoxin 2 (PRDX2) is an antioxidant enzyme that uses cysteine residues to decompose peroxides. Peroxiredoxin-2 (PRDX2), an enzyme reducing hydrogen peroxide and lipid peroxides Peroxiredoxin 2 (Prx2) is a thiol-dependent peroxidase.

Describe RCandy

RCandy is a platform-independent R package for rapid, simple, and flexible visualisation of recombination events in bacterial genomes.

What is dovitinib?

Dovitinib (TKI258) is a tyrosine kinase receptor inhibitor with potent activity against fibroblast growth factor receptor (FGFR) and vascular endothelial growth factor receptor (VEGFR).

What is the proteoglycan Tsukushi?

Tsukushi (TSK), a member of the small leucine-rich repeat proteoglycan (SLRP) family, plays multifunctional roles by interacting with signaling molecules during development. In lung cancer cells, TSK is expressed more highly than the other SLRPs family members, and regulates the EMT and proliferation. Thus, TSK may be a key coordinator of multiple pathways and an important structural element in the lung cancer microenvironment. Gain- and loss-of-function analyses showed that the small leucine-rich proteoglycan, tsukushi, contributes to vitamin K2-mediated enhancement of collagen accumulation.

Which disease is treated with Nusinersen?

Nusinersen us used for treatment of Spinal Muscular Atrophy.

Which are the most widely used computational methods for the identification of CRMs (cis-regulatory modules)?

Computational methods attempting to identify instances of cis-regulatory modules (CRMs) in the genome face a challenging problem of searching for potentially interacting transcription factor binding sites while knowledge of the specific interactions involved remains limited. When discriminating CRMs from non-coding regions, those methods considering evolutionary conservation have a stronger predictive power than methods designed to be run on a single genome. Furthermore, most methods appear to be sensitive to the composition and structure of the genome to which they are applied. CisMiner allows to perform a blind search of CRMs without any prior information about target CRMs nor limitation in the number of motifs.

Where does REGN5458 bind to?

The bispecific antibody REGN5458 binds to B-cell maturation antigen (BCMA) and CD3.

What is the function of the protein encoded by the gene PABPC4?

The main function of PABPC4 is in mRNA stability and translation initiation. PABPC4 may also play a role in chronic inflammation and in the pathogenesis of colorectal cancer.

Mutations in which gene form the genetic basis of the DOORS syndrome?

Mutations in TBC1D24 seem to be an important cause of DOORS syndrome and can cause diverse phenotypes. Thus, individuals with DOORS syndrome without deafness and seizures but with the other features should still be screened for TBC1D24 mutations. More information is needed to understand the cellular roles of TBC1D24 and identify the genes responsible for DOORS phenotypes in individuals who do not have a mutation in TBC1D24.

Can gene therapy restore auditory function?

Yes, gene therapy can restore auditory function.

Is neurofilament light marker for disease?

Yes, Serum neurofilament light chain (sNfL) is a marker of neuroaxonal injury leading to numerous diseases such as frontotemporal dementia (FTD) and Multiple sclerosis (MS).

Which organizations approved Tagsedi in 2018?

In 2018 Tagsedi was approved by the United States Food and Drug Agency, Health Canada, and European Commission.

Is cadherin a plasma membrane marker?

Yes, cadherin is a plasma membrane protein marker.

What is the efficacy of oxaliplatin monotherapy in the management of colorectal cancer?

Oxaliplatin is a promising treatment option for patients with metastatic colorectal cancer. It appears to be particularly advantageous (in terms of response rate and duration of progression-free survival) when used in combination with fluorouracil/calcium folinate as both a first- and second-line option, although preliminary studies have failed to show any survival advantage over fluorouracil/calcium folinate alone. Promising results have been found in studies of the drug as monotherapy, and oxaliplatin may also prove useful in the neoadjuvant setting in patients with unresectable liver metastases; however, data are limited at present

What is the mechanism of action of Solriamfetol?

Solriamfetol is a selective norepinephrine-dopamine reuptake inhibitor. It is used to treat excessive sleepiness in obstructive sleep apnea and narcolepsy patients.

Is Li–Fraumeni syndrome a rare, autosomal recessive, hereditary disorder that predisposes carriers to cancer development?

Li-Fraumeni syndrome is a rare, autosomal DOMINANT, hereditary disorder that predisposes carriers to cancer development.

Is phospholamban phosphorylated by Protein kinase A?

Phospholamban (PLB) is a sarcoplasmic reticulum (SR) protein that is phosphorylated at Ser16 by PKA. Phosphorylation of PLB by PKA reverses the inhibitory action of PLB.

Which are the APOBEC3 protein family members able to inhibit Vif-deficient HIV-1 replication?

APOBEC3G, APOBEC3F, APOBEC3DE, APOBEC3A, and APOBEC3H haplotypes II, V, and VII, provide protection against Vif-deficient HIV-1, through hypermutation of the viral genome, inhibition of reverse transcription, and inhibition of viral DNA integration into the host genome.

Which epigenetic mark is deposited by PRC2?

H3K27me3 is the major histone methyltransferase activity of PRC2.

What is the synonym of the lubag disease?

Lubag disease is also known as X-linked dystonia-parkinsonism (XDP). This disease is characterized by dystonia and parkinsonism, and afflicts Filipino men, and rarely, women originating principally from the Panay Island.

Does association with the nuclear pore promote gene silencing?

MicroRNA (miRNA)-guided mRNA repression, mediated by the miRNA-induced silencing complex (miRISC), is an important component of post-transcriptional gene silencing. The nucleoporin Nup358 plays an important role in this process

Which class of genomic elements was assessed as part of the FANTOM6 project?

Long noncoding RNAs (lncRNAs) constitute the majority of transcripts in the mammalian genomes, and yet, their functions remain largely unknown. As part of the FANTOM6 project, the expression of 285 lncRNAs was systematically knocked down in human dermal fibroblasts. Cellular growth, morphological changes, and transcriptomic responses were quantified using Capped Analysis of Gene Expression (CAGE).

What is ECMO?

Extracorporeal membrane oxygenation (ECMO) is an increasingly prevalent treatment for acute respiratory failure (ARF)

Does Amblyopia affect the eye?

Amblyopia, also called lazy eye, is a disorder of sight in which the brain fails to process inputs from one eye and over time favors the other eye. It results in decreased vision in an eye that otherwise typically appears normal

Is there any involvement of the long non-coding RNA Gomafu in schizophrenia?

Yes. The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing.

Describe the mechanism of action of apalutamide.

Apalutamide is a second-generation antiandrogen that inhibits the binding of androgen to androgen receptor (AR), nuclear translocation of the androgen-AR complex, and binding of AR transcription complex to DNA-binding sites and transcription elements. It does not show antagonist-to-agonist switch like bicalutamide. It is emerging as additional new option to treat castration-resistant prostate cancer.

Is the protein FAK (Focal Adhesion Kinase) phosphorylated?

yes, the protein FAK (Focal Adhesion Kinase) is phosphorylated.

Which is the transcriptome of RNA polymerase III?

RNA polymerase III (Pol III) transcribes a limited set of short genes in eukaryotes producing abundant small RNAs, mostly tRNA. The originally defined yeast Pol III transcriptome appears to be expanding owing to the application of new methods. Newly identified Pol III transcripts include small nucleolar RNAs, microRNAs, short interspersed nuclear element-encoded or tRNA-derived RNAs and novel classes of ncRNA that can display significant sequence complementarity to protein-coding genes and might thus regulate their expression.

Which is the main ligand for the glucocorticoid receptor?

Glucocorticoids (GC) such as cortisol regulate multiple physiological functions, notably those involved in development, metabolism, inflammatory processes and stress, and exert their effects upon binding to the glucocorticoid receptor (GR, encoded by NR3C1 gene in humans).

Is LRP1 interacting with Urokinase receptor?

Yes

Roflumilast Cream is effective for which disease?

Roflumilast Cream has been shown to be effective for psoriasis.

Which gene is responsible for red hair?

Variants of the melanocyte-stimulating hormone receptor gene are associated with red hair and fair skin in humans.

Which proteins are the different members of the NF-kappaB family of transcription factors?

Nuclear factor kappa B (NFκB) is a dimeric transcription factor comprised of five family members RelA (p65), RelB, c-Rel, NF-kB1/p50 and NF-kB2/p52.

Which signalling pathway is involved in Tuberous Sclerosis?

Tuberous Sclerosis is a multisystem genetic disorder caused by mutation in TSC1 or TSC2 gene, that leads to hyperactivation of the mTOR signalling pathway, and subsequent dysregulation of cell growth control.

What are the effects of STEF depletion?

The mechanisms regulating the actin cap are currently poorly understood. STEF/TIAM2, a Rac1 selective guanine nucleotide exchange factor, localises at the nuclear envelope, co-localising with the key perinuclear proteins Nesprin-2G and Non-muscle myosin IIB (NMMIIB), where it regulates perinuclear Rac1 activity. STEF depletion reduces apical perinuclear actin cables (a phenotype rescued by targeting active Rac1 to the nuclear envelope), decreases nuclear stiffness and reduces expression of TAZ-regulated genes, indicating an alteration in mechanosensing pathways as a consequence of disruption of the actin cap.

Describe the syndrome that is caused by biallelic variants in HPDL

Biallelic HPDL variants cause a syndrome varying from juvenile-onset pure hereditary spastic paraplegia to infantile-onset spastic tetraplegia associated with global developmental delays.

What is vcfanno?

Vcfanno flexibly extracts and summarizes attributes from multiple annotation files and integrates the annotations within the INFO column of the original VCF file. Substantial performance gains are reported by annotating ~85,000 variants per second with 50 attributes from 17 commonly used genome annotation resources. Vcfanno is available at https://github.com/brentp/vcfanno under the MIT license.

Which human tissue synthesize CRP?

CRP is predominantly produced in the liver in a native pentameric form (nCRP).

What does iBAQ stand for in proteomic analysis?

iBAQ stands for intensity-based absolute quantification.

Is acupotomy used to treat muscle stiffness?

Yes. Acupotomy has been widely used to treat nerve entrapment syndrome. URL_0

Does triiodothyronine play a regulatory role in insulin secretion from pancreas?

YES