Datasets:

enelpol

/

rag-mini-bioasq-with-metadata

like 2

Follow

Enelpol 10

Which part of the TNFR2 gene is genetically associated with Systemic Lupus Erythematosus?

There is a TNFR2 3' flanking region polymorphism in systemic lupus erythematosus.

what is the role of GATA-4 in regeneration of the heart after myocardial infarction?

GATA-4 is implicated in cardiogenic differentiation of cardiac c-kit+AT2+ cells that represent approximately 0.19% of total cardiac cells in infarcted heart. GATA-4 overexpression in mesenchymal stem cells increases both survival and angiogenic potential in ischemic myocardium and may therefore represent a novel and efficient therapeutic approach for postinfarct regenaration. In addition, interventions, such as hypergravity and 5-Aza treatment, induce expression of early muscle and cardiac markers like GATA-4 in BMSCs. A subpopulation of primitive cells from rat heart, expressing c-kit and myogenic transcriptional factors, GATA-4 and MEF 2C, exhibit a high in vitro proliferative potential. Progeny of these implanted cells have been shown to migrate along the infarcted scar, reconstitute regenerated cardiomyocytes with incorporation into host myocardium, and inhibit cardiac remodeling with decreased scar formation. In another study, TGF-beta has been shown to conduct the myogenic differentiation of stem cells by upregulating GATA-4 and NKx-2.5 expression and the intramyocardial implantation of TGF-beta-preprogrammed stem cells effectively assisted the myocardial regeneration. Furthermore, G-CSF treatment in postinfarcted murine hearts appears to be an effective approach for treating heart failure and also leads to induction of GATA-4 resulting in expression of various sarcomeric proteins.

Which method for subsampling of NGS reads requires only gene counts?

SamExploreR : exploring reproducibility and robustness of RNA-seq results based on SAM files.We introduce the subseq r package, which uses a novel efficient approach to perform this subsampling and to calculate informative metrics at each depth required to inform a broad range of functional and evolutionary studies.Our methods are broadly applicable for polymorphism discovery in moderate to large genomes even at highly diverged loci, and we established by subsampling the illumina sbs coverage depth related questions for the experimental design.SubSeq : determining appropriate sequencing depth through efficient read subsampling.

Which receptor is inhibited by bimagrumab?

Bimagrumab is a fully human monoclonal antibody that blocks the activin type II receptors, preventing the activity of myostatin and other negative skeletal muscle regulators.

What is the 4D nucleome project?

The 4D Nucleome Network aims to develop and apply approaches to map the structure and dynamics of the human and mouse genomes in space and time with the goal of gaining deeper mechanistic insights into how the nucleus is organized and functions. The project will develop and benchmark experimental and computational approaches for measuring genome conformation and nuclear organization, and investigate how these contribute to gene regulation and other genome functions. Validated experimental technologies will be combined with biophysical approaches to generate quantitative models of spatial genome organization in different biological states, both in cell populations and in single cells.

Is ABCE1 involved in ribosomal recycling?

Yes, recent studies have identified ABCE1 as a ribosome-recycling factor important for translation termination in mammalian cells, yeast and also archaea

What are congenital disorders of glycosylation?

Congenital disorders of glycosylation (CDG) are a growing group of inherited metabolic disorders where enzymatic defects in the formation or processing of glycolipids and/or glycoproteins lead to variety of different diseases. More than 100 rare human genetic disorders that result from deficiencies in the different glycosylation pathways are known today. The patients have hundreds of misglycosylated products, which afflict a myriad of processes, including cell signaling, cell-cell interaction, and cell migration.

What is the mechanism of action of Tezepelumab?

Tezepelumab is human monoclonal antibody specific for the epithelial-cell-derived cytokine thymic stromal lymphopoietin (TSLP).

How do the plasma concentrations of amantadine extended release and amantadine immediate release compare?

When it is given at bedtime, it reaches plasma concentration approximately twice the level achieved by amantadine immediate release.

Is the protein pelota a ribosomal rescue factor?

Yes, in eukaryotes, Pelota (Dom34 in yeast) and Hbs1 are responsible for solving general problems of ribosomal stall in translation.

Which web-based pedigree editors are available?

Pedigreejs and Madeline 2.0 Pedigree Drawing Engine (PDE)

What does bDMARD stand for?

bDMARDs are biologic disease-modifying antirheumatic drugs.

What is known about food intolerance and gluten ?

Celiac disease, with a prevalence around 1% of the general population, is the most common genetically-induced food intolerance in the world. Triggered by the ingestion of gluten in genetically predisposed individuals. Emerging research into a syndrome known as nonceliac gluten sensitivity suggests a heterogeneous condition with some features of celiac disease but often categorized as FGIDs, including IBS.

Which signaling pathway does LY294002 inhibit?

LY294002, can block the PI3K/AKT signaling pathway.

Is the Wnt protein modified by notum?

Yes, Notum deacylates Wnt proteins to suppress signalling activity.

Are long non coding RNAs as conserved in sequence as protein coding genes?

No. Most long non coding RNAs (lncRNAs) are under lower sequence constraints than protein-coding genes.

What is the definition of minimal absent words?

An absent word of a word y of length n is a word that does not occur in y. It is a minimal absent word if all its proper factors occur in y. Minimal absent words have been computed in genomes of organisms from all domains of life; their computation also provides a fast alternative for measuring approximation in sequence comparison.

How many genes belong to the KRAB-ZNF family in the human genome?

The KRAB-ZNF family is a multisubunit protein family comprised of 70 co-regulated genes, denoted KLR1-ZNF15, that is represented by multigene families in the human genome.

Which disease is linked to mutations within BRAG1?

Mutations in BRAG1 have been identified in families with X-linked intellectual disability (XLID).

Is deletion at 6q24.2-26 associated with shorter survival for ovarian cancer patients?

No, the 6q24.2-26 deletion is an independent marker of favorable outcome in high-grade serous ovarian carcinoma (HGSOC) patients with potential clinical value as it can be analyzed by FISH on tumor sections and guide the selection of patients towards more conservative therapeutic strategies in order to reduce side-effects and improve quality of life.

Does p85α homodimerize?

p110α-free p85α homodimerizes

What is filgotinib?

Filgotinib is an oral selective Janus kinase inhibitor. It has been tested in patients with rheumatoid arthritis and Chroni's disease, and has been shown to be safe and efficacious.

Which medical diagnostic tests are used to test kidney function?

Most common tests used in diagnosing normal kidney function include blood tests such as serum creatinine levels, glomerular filtration rate (GFR) and blood urea nitrogen (BUN) levels, also medical imaging tests like ultrasound and CT Scan. Additionally kidney biopsy is used in more direct but invasive approach. Lastly, and probably the most relevant tests to kidney function are urine tests along the lines of urinalysis, urine protein levels and microalbuminuria creatinine clearance.

Is Lysine-specific demethylase 1 (LSD1) a critical regulator of hematopoiesis?

Yes. Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation of erythroid, granulomonocytic and megakaryocytic progenitors.

Signaling of which pathways is inhibited by Dupilumab?

Dupilumab, a fully human anti-interleukin-4 receptor α monoclonal antibody, inhibits interleukin-4 and interleukin-13 signalling. It is used for treatment of atopic or allergic diseases.

Can you summarize Myasthenia Gravis?

Myasthenia gravis (MG) is a neuromuscular disease which affects the central nervous system, dorsal root ganglia of the spinal cord, heart and in certain cases the pancreas. Two thirds of MG cases result from sporadic genetic mutations, not inheritance, but their offspring may inherit it from them.

Is Tisagenlecleucel effective for B-Cell Lymphoma?

Yes, CD19-targeting CAR T-cell therapy tisagenlecleucel produces durable responses in patients with relapsed and refractory diffuse large B-cell lymphoma.

What pathological phenotype could potentially concomitant pomegranate juice and rosuvastatin use cause?

Concomitant use of rosuvastatin and pomegranate juice has been hypothesized to be associated with the development of rhabdomyolysis in a case report.

What is the most common N6-methyladenosine (m6A) methylation modification site of RUNX1T1?

The RRACH motif is the most common N6-methyladenosine (m6A) methylation modification site of RUNX1T1.

Which protein is encoded by the protein APOBEC3C?

The gene APOBEC3C codes for: apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3C

What is the Formalin test used for?

And persistent pain produced by peripheral tissue injury and inflammation was modeled by formalin test.

What is "long-COVID"?

"Long-COVID" is a complex condition where the affected individuals do not recover for several weeks or months following the onset of symptoms suggestive of COVID-19, and the symptoms are not explained by an alternative diagnosis. Persistent physical symptoms following acute COVID-19 are common and typically include fatigue, dyspnea, chest pain, and cough. Headache, joint pain, myalgias, and loss of smell have also been reported. Common psychological and cognitive symptoms include poor concentration, cognitive impairment/confusion, insomnia, and overall reduced quality of life.

How is CTCF activated post-translationally?

The chromatin insulator protein CTCF carries a post-translational modification: poly(ADP-ribosyl)ation.

What is ASTRAL Score?

ASTRAL Score is used to predict prognosis of stroke patients.

What is the function of the protein PIEZO1?

Piezo1 is a key element of the mechanotransduction process and can transduce mechanical signals into biological signals by mediating Ca2+ influx, which in turn regulates cytoskeletal remodeling and stress alterations.

List the major families of Histones.

Five histone families (H1, H2A, H2B, H3, and H4).

Which metabolic pathways have been associated with Systemic Lupus Erythematosus?

Genetic polymorphisms of the xenobiotic metabolic pathway involved in estrogen metabolism might contribute towards pathophysiology of systemic lupus erythematosus (SLE). According to the analysis on metabolic pathway, SLE could cause significant changes in unsaturated fatty acid and amino acid metabolism pathway. Results suggest reducing FLI1 in lupus decreases the pathogenicity of T cells by decreasing TCR-specific activation and IL-4 production in part through the modulation of glycosphingolipid metabolism

List the four most important interferonopathies

Aicardi-Goutières syndrome chilblain lupus ubiquitin specific peptidase 18 (USP18)-deficiency Singleton-Merten syndrome

Which are the known human transmembrane nucleoporins?

Transmembrane nucleoporins (NUPs) are integral membrane components of the eukaryotic nuclear pore, playing an important role in the Nuclear Pore Complex (NPC) assembly. Even though the NPC is a conserved feature of all eukaryotes, different lineages possess some distinct transmembrane NUP subunits. Currently, four human transmembrane NUPs have been characterized, namely: NDC1 (also known as TMEM48 or NET3 or hNDC1), POM121 (also known as Nup121), GP210 (also known as Nuclear pore membrane glycoprotein 210 or Nuclear envelope pore membrane protein POM 210, POM210 or Nup210) and TMEM33 (or DB83).

Is carpal tunnel syndrome a type of nerve entrapment?

Carpal tunnel syndrome (CTS) is the most frequent entrapment neuropathy in humans.

Which resource has been developed in order to study the transcriptional regulation of GABAergic cell fate?

Subpallial Enhancer Transgenic Lines is a data and tool resource to study transcriptional regulation of GABAergic cell fate.

Have C12orf65 mutations been associated with axonal neuropathy and optic atrophy?

Novel C12orf65 mutations in patients with axonal neuropathy and optic atrophy

Is Rad4/XPC a DNA damage sensing protein?

Yes, DNA damage recognition is achieved by the Rad4/XPC nucleotide excision repair complex.

Does radiation for tinea capitis increases brain tumor risk?

Yes, radiation therapy for tinea capitis is associated with increased risk of meningiomas and gliomas.

How are induced pluripotent stem cells used in the study and treatment of cardiovascular diseases?

The major goal within the field of cardiovascular regenerative medicine is to replace lost or damaged cardiac muscle and coronaries following ischaemic disease. At present, de novo cardiomyocytes can be generated either in vitro, using directed differentiation of embryonic stem cells or induced pluripotent stem cells, or in vivo via direct reprogramming of resident adult cardiac fibroblast or ectopic stimulation of resident cardiac stem or progenitor cells. The production of human cardiac progenitor cells and cardiomyocytes from human pluripotent stem cells provides an amenable source of cells for applications in drug discovery, disease modeling, regenerative medicine, and cardiotoxicity screening. In addition, the ability to derive human-induced pluripotent stem cells from somatic tissues, combined with current high-throughput screening and pharmacogenomics, may help realize the use of these cells to fulfill the potential of personalized medicine. Human induced pluripotent stem cells (iPSC) provide a unique opportunity to study "disease in a dish" within a defined genetic and environmental background. Patient-derived iPSCs have been successfully used to model cardiomyopathies, rhythm disorders and vascular disorders. Long-QT syndrome and catecholaminergic polymorphic ventricular tachycardia are two heart rhythm disorders that have been already successfully modeled by several groups using this approach, which will likely serve to model other mono- or polygenetic cardiovascular disorders in the future. The use of iPSC-derived cardiomyocytes to study genetic cardiovascular disorders will enable a deeper and more applicable understanding of the molecular mechanisms of human disease, as well as improving our ability to achieve successful cell-based therapies.

Does the word ovine refers to goats?

Ovine refers to sheep.

Could bioprinting be used in regenerative medicine against bone disease?

The developments in bioprinting (3D cell printing) techniques will be used in regenerative medicine and may allow the fabrication of customized implants for patients suffering in bone diseases in the future, once several technological limitations are addressed.

What type of arrhythmia is known as bidirectional ventricular tachycardia (BDVT)?

Bidirectional ventricular tachycardia (BVT), which is characterized by an alternating beat-to-beat ECG QRS axis, is a rare but intriguing arrhythmia associated with digitalis toxicity, familial catecholaminergic polymorphic ventricular tachycardia (CPVT), and several other conditions that predispose cardiac myocytes to delayed afterdepolarizations (DADs) and triggered activity. Bidirectional ventricular tachycardia (BVT) is an uncommon type of polymorphic ventricular tachycardia (PVT). Based on similarity of electrocardiographic features, bidirectional ventricular tachycardia has been considered a variant of long QT syndrome. Evidence from human and animal studies attributes BVT to alternating ectopic foci originating from the distal His-Purkinje system in the left and/or right ventricle, respectively. This "ping pong" mechanism of reciprocating bigeminy readily produces the characteristic ECG pattern of BVT and its degeneration to polymorphic VT if additional sites develop bigeminy.

What is the link between lithium use during pregnancy and Ebstein anomaly?

It is generally believed that lithium use is associated with increased risk of Ebstein anomaly. However, more recent studies challenge this association.

Which individuals show preferential colonization of the Prevotellaceae bacteria in their guts?

Although the distinction of enterotypes as either discrete clusters or a continuum will require additional investigation, numerous studies have demonstrated the co-exclusion of the closely related Prevotellaceae and Bacteroides genera in the gut microbiota of healthy human subjects where Prevotella appears to be a discriminatory taxon for residence in more agrarian societies.

In which aspects of the immune response is m6A methylation implicated?

m6A is a novel regulator of immune system homeostasis and activation. m6A modifications and m6A modifying proteins play a critical role in pathogen recognition, immune cell activation, immune cell fate decisions, and immune reactions. These modifications modulate the fate decisions of innate and adaptive immune cells and regulate immune responses in immune-associated diseases, including viral infections and cancer.

What can Nothobranchius furzeri be used as a model system for?

N. furzeri an interesting model system to investigate the effects of experimental manipulations on longevity and age-related pathologies. N. furzeri could represent a model system for studying the genetic control of life-history traits in natural populations. N. furzeri could be a very useful model for comparative genomics of aging. It can be employed to test the effects of experimental manipulation on aging and apharmacological research.

PH motifs in which genes endow breast cancer growth?

Although emerging roles of protease-activated receptor1&2 (PAR1&2) in cancer are recognized, their underlying signalling events are poorly understood. Signal-binding motifs in PAR1&2 are critical for breast cancer growth. This occurs via the association of the pleckstrin homology (PH) domain with Akt/PKB as a key signalling event of PARs. Other PH-domain signal-proteins such as Etk/Bmx and Vav3 also associate with PAR1 and PAR2 through their PH domains. PAR1 and PAR2 bind with priority to Etk/Bmx. A point mutation in PAR2, H349A, but not in R352A, abrogates PH-protein association and is sufficient to markedly reduce PAR2-instigated breast tumour growth in vivo and placental extravillous trophoblast (EVT) invasion in vitro. Similarly, the PAR1 mutant hPar1-7A, which is unable to bind the PH domain, reduces mammary tumours and EVT invasion, endowing these motifs with physiological significance and underscoring the importance of these previously unknown PAR1 and PAR2 PH-domain-binding motifs in both pathological and physiological invasion processes.

What does polyadenylate-binding protein 4 (PABP4) bind to?

PABP4 binds mRNA poly(A) tails.

List Alkaptonuria Triad.

Alkaptonuria is a rare inherited genetic disorder of tyrosine metabolism characterized by a triad of homogentisic aciduria, ochronosis, and arthritis.

Is there a dependence between chromatin organization and dorsoventral gene expression in Drosophila?

No. There is independence of chromatin conformation and gene regulation during Drosophila dorsoventral patterning

Which algorithm has been developed for detecting expansions of tandem repeats?

Identifying large expansions of short tandem repeats (STRs), such as those that cause amyotrophic lateral sclerosis (ALS) and fragile X syndrome, is challenging for short-read whole-genome sequencing (WGS) data. A solution to this problem is an important step toward integrating WGS into precision medicine. For that purpose, ExpansionHunter has been developed as a software tool that, using PCR-free WGS short- read data, can genotype repeats at the locus of interest, even if the expanded repeat is larger than the read length.

What is the "Proteomic ruler"?

The MS signal of histones can be used as a "proteomic ruler" because it is proportional to the amount of DNA in the sample, which in turn depends on the number of cells. As a result, our proteomic ruler approach adds an absolute scale to the MS readout and allows estimation of the copy numbers of individual proteins per cell.

What is Genomicus?

Genomicus had been developed as a database and a browser to study gene synteny in modern and ancestral genomes. It allows easy comparative genomic visualization in >150 eukaryote genomes and in four different phyla (Vertebrate, Fungi, Metazoan and Plants). It provides a way to explore spatial information related to gene organization within and between genomes and temporal relationships related to gene and genome evolution. For the specific vertebrate phylum, it also provides access to ancestral gene order reconstructions and conserved non-coding elements information. The graphical modules of Genomicus show how it is capable of revealing differential gene loss and gain, segmental or genome duplications and facilitate the study of the evolution of a locus through homology relationships. The Genomicus server provides access to ancestral gene orders, as well as computationally predicted regulatory interactions, thanks to the representation of conserved non-coding elements with their putative gene targets.

Does the interaction of MOV10 and RNASEH2 promote L1 retrotransposition?

MOV10 interacts with RNASEH2, and their interplay is crucial for restricting L1 retrotransposition.

Are the Fanconi anemia genes a part of the same signalling pathway?

The FA genes code for proteins that act in complexes to coordinate the repair of damaged DNA

What are the characteristics of the "Universal Proteomics Standard 2" (UPS2)?

The UPS2 proteomic dynamic range standard was introduced by the Association of Biomolecular Resource Facilities Proteomics Standards Research Group in 2006 and it has a dynamic range of 5 orders of magnitude.

What is the genetic basis of tuberous sclerosis?

The genetic basis of tuberous sclerosis has been attributed to mutations in one of two unlinked genes, TSC1 and TSC2. The functions of the TSC1 and TSC2 gene products, hamartin and tuberin, respectively, have remained ill defined until recently. Genetic, biochemical, and biologic analyses have highlighted their role as negative regulators of the mTOR signaling pathway. Tuberin, serving as a substrate of AKT and AMPK, mediates mTOR activity by coordinating inputs from growth factors and energy availability in the control of cell growth, proliferation, and survival. Emerging evidence also suggests that the TSC 1/2 complex may play a role in modulating the activity of beta-catenin and TGFbeta. These findings provide novel functional links between the TSC genes and other tumor suppressors.

Which protein is the E3-ubiquitin ligase that targets the tumor suppressor p53 for proteasomal degradation?

The p53 tumour suppressor protein is tightly controlled by the E3 ubiquitin ligase, mouse double minute 2 (MDM2). The RING domain E3 ubiquitin ligase Mdm2 is the master regulator of the tumor suppressor p53. It targets p53 for proteasomal degradation, restraining the potent activity of p53 and enabling cell survival and proliferation. p53 is inactivated in many human malignancies through missense mutations or overexpression of the human homologue of Mdm2 (Hdm2), an E3 ubiquitin ligase that ubiquitinates p53, thereby promoting its proteasomal degradation.

Is Semagacestat effective for treatment of Alzheimer's disease?

No. In clinical trial semagacestat did not improve cognitive status, and patients receiving the higher dose had significant worsening of functional ability. Semagacestat was associated with more adverse events, including skin cancers and infections.

Do mutations of AKT1 occur in meningiomas?

Yes, AKT1 mutation occurs in meningiomas.

List 4 monoclonal antibodies in development for the prevention of migraine.

Four monoclonal antibodies targeting either the CGRP ligand or receptor are being studied for migraine prevention: ALD403 (eptinezumab), AMG 334 (erenumab), LY2951742 (galcanezumab), and TEV-48125 (fremanezumab)

Does trimetazidine protect from myocardial injury after percutaneous coronary intervention?

Oral trimetazidine 35 mg twice daily over several years in patients receiving optimal medical therapy, after successful PCI, does not influence the recurrence of angina or the outcome; these findings should be taken into account when considering the place of trimetazidine in clinical practice.

Is resistance training usually associated with increasing muscle hypertrophy?

Traditional resistance exercises have been widely used to promote muscle strength and hypertrophy.

Does BNN27 promote memory loss?

No. The novel dehydroepiandrosterone (DHEA) derivative BNN27 counteracts delay-dependent and scopolamine-induced recognition memory deficits in rats.

What is the genetic basis of progeria?

Hutchinson-Gilford progeria syndrome is a rare, sporadic, autosomal dominant syndrome that involves premature aging, generally leading to death at approximately 13 years of age due to myocardial infarction or stroke. The genetic basis of most cases of this syndrome is a change from glycine GGC to glycine GGT in codon 608 of the lamin A (LMNA) gene, which activates a cryptic splice donor site to produce abnormal lamin A; this disrupts the nuclear membrane and alters transcription.

What memory problems are reported in the " Gulf war syndrome"?

Loss of memory and dysmnesia are memory problems reported in the " Gulf war syndrome". Patients suffering from this syndrome often have other nonspecific symptoms such as fatigue, skin rash, headache, muscle and joint pain and sexual dysfunction.

Is amiodarone a class I anti-arrhythmic drug?

Although considered to be a class III anti-arrhythmic, amiodarone also has class I, II and IV actions, which gives it a unique pharmacological and anti-arrhythmic profile

What is Dupuytren's contracture?

Dupuytren's contracture is a progressive hand condition that affects how much you can move or straighten your fingers. It is a benign fibroproliferative disease leads to hyperplasia of the collagen fibers of the fascia of the palm, which can result in severe impairment of the functionality of the hand.

Which workflow in Bioconductor has been developed for accessing human RNA-seq samples?

The recount2 resource is composed of over 70,000 uniformly processed human RNA-seq samples spanning TCGA and SRA, including GTEx.

Do the proteins Talin and Amot interact?

Yes, Amot binds Talin

What is the function of the YY1 transcriptional regulator?

The ubiquitous transcription factor Yin Yang 1 (YY1) is known to have a fundamental role in normal biologic processes such as embryogenesis, differentiation, replication, and cellular proliferation. YY1 is a transcription factor that can activate or repress transcription of a variety of genes and is involved in several developmental processes. YY1 overexpression and/or activation is associated with unchecked cellular proliferation, resistance to apoptotic stimuli, tumorigenesis and metastatic potential. YY1, in addition to its regulatory roles in normal biologic processes, may possess the potential to act as an initiator of tumorigenesis and may thus serve as both a diagnostic and prognostic tumor marker; furthermore, it may provide an effective target for antitumor chemotherapy and/or immunotherapy.

Describe the web application VICTOR

VICTOR is a free, dependency-free visual analytics web application that allows the visual comparison of the results of various clustering algorithms. It can handle multiple cluster set results simultaneously and compare them using ten different metrics. Clustering results can be filtered and compared with the use of data tables or interactive heatmaps, bar plots, correlation networks, sankey and circos plots.

What is the role of alcohol acyl transferases in fruit aroma?

Volatile esters, a major class of compounds contributing to the aroma of many fruit, are synthesized by alcohol acyl-transferases (AAT). The expression of all Cm-AAT genes is up-regulated during ripening and inhibited in antisense ACC oxidase melons and in fruit treated with the ethylene antagonist 1-methylcyclopropene (1-MCP), indicating a positive regulation by ethylene.

List T-UCRs that have been implicated in breast cancer

Long non-coding RNAs (lncRNAs) are transcripts longer than 200 bp with no protein-coding capacity. Transcribed ultraconserved regions (T-UCRs) are a type of lncRNA and are conserved among human, chick, dog, mouse and rat genomes. These sequences are involved in cancer biology and tumourigenesis. Overexpression of one specific T-UCRs named uc.63 is associated with bad outcome in luminal A subtype of breast cancer patients. Uc.38 negatively regulates the expression of the pre-B-cell leukaemia homeobox 1 (PBX1) protein and subsequently affects the expression of Bcl-2 family members, ultimately inducing breast cancer cell apoptosis.

In which cellular compartment do stress granules localize?

cytoplasm

Are mucins glycosylated proteins?

Yes, Many members of the mucin family are evolutionarily conserved and are often aberrantly expressed and glycosylated in various benign and malignant pathologies leading to tumor invasion, metastasis, and immune evasion.

What is the function of penicillinase, also known as beta lactamase?

Beta-lactamases are a family of serine enzymes that hydrolyse beta-lactam antibiotics following an acylation-deacylation mechanism.

What are 7 symptoms of yellow fever?

Yellow fever is considered to be a hemorrhagic fever and illness is characterized by fever, headache, myalgia, gastrointestinal symptoms, hepatic and renal dysfunction, multi-organ failure, shock and coagulopathy.

Is there any algorithm for enhancer identification from chromatin state?

yes

In which condition was protein S100A7 originally identified?

Psoriasin (S100A7) was originally identified in psoriasis.

Has istadefylline been considered as a treatment for Parkinson's disease?

Yes, istradefylline is a new drug developed for the treatment of Parkinson's disease.

What distinguishes RIDLs from other transpozable elements?

Here, we link these two concepts by proposing that exonic TEs act as RNA domains that are essential for lncRNA function. We term such elements Repeat Insertion Domains of LncRNAs (RIDLs).

Which server is used for simulation of macromolecular diffusional association?

Macromolecular interactions play a crucial role in biological systems. Simulation of diffusional association (SDA) is a software for carrying out Brownian dynamics simulations that can be used to study the interactions between two or more biological macromolecules. webSDA allows users to run Brownian dynamics simulations with SDA to study bimolecular association and encounter complex formation, to compute association rate constants, and to investigate macromolecular crowding using atomically detailed macromolecular structures. webSDA facilitates and automates the use of the SDA software, and offers user-friendly visualization of results.

What is the function of PARP1?

parp1 is the most abundant and best-characterized member of the family of parp enzymes. the poly(adp-ribose) polymerases (parps) catalyze poly(adp-ribosyl)ation, a post-translational modification of proteins.

What is the association between number of pregnancies and rheumatoid arthritis

Greater parity significantly reduced the odds of RA. A larger number of pregnancies and late menopause show a protective effect, delaying the onset of the disease.

Which company developed ivosidenib?

Ivosidenib has been developed by Agios Pharmaceuticals.

Which interleukin is blocked by Siltuximab?

Siltuximab is a monoclonal antibody that binds to interleukin-6 with high affinity and specificity.

Which brain tumors does neuroligin-3 promote?

Neuroligin-3 promotes the growth of high-grade gliomas.

Is Thalidomide currently a marketed drug?

Several mechanisms for the teratogenic action of thalidomide are currently under review, but this mode of action of the drug still remains unclear and we review evidence-based hypotheses for the teratogenicity of thalidomide. Thalidomide is considered the drug of choice for the treatment of ENL, but for other conditions, it is recommended only when resistance to the currently available form of therapy is encountered. THE USE OF A DRUG WITH A TEMPORARY MARKETING AUTHORISATION: Thalidomide is currently available in France for nominative or cohort use with a temporary marketing authorisation (TMA). Examples of the basis for such regulation are drawn from historical situations (thalidomide, benoxaprofen) as well as currently marketed drugs (arylpropionic acids, disopyramide, indacrinone). In 1998 the US Food and Drug Administration approved thalidomide exclusively for the treatment of ENL, and strict conditions were stipulated for its use in order to prevent teratogenic adverse effects. The US Food and Drug Administration (FDA) has approved Thalomid (thalidomide) capsules for the acute treatment of the cutaneous manifestations of moderate to severe ENL. The revival of thalidomide began shortly after the drug was withdrawn from the market because of its teratogenic properties.

What is the treatment of neuropathic pain in children?

It is unclear if any treatment is registered for pediatric use. The reported treatments are: Oxcarbazepine Opioids alone, in rotations or with Analgesics (e.g. Ketamine and Lidocaine infusion) Opioids and Benzodiazepines Pregabalin - is one of the first drugs registered for the treatment of neuropathic pain. It is unclear if Pregabalin is registered for the treatment of neuropathic pain in children specifically but it is being used in practice. Tricyclic Antidepressants Lidocaine 5% patches for chronic localized neuropathic pain

What is a "cytokine storm"?

During infectious processes, the production of inflammatory cytokines including tumor necrosis factor (TNF), interleukin-1b (IL-1b), gamma interferon (IFNg) and chemokines orchestrates the anti-infectious innate immune response. However, an overzealous production, leading up to a cytokine storm, can be deleterious and contributes to mortality consecutive to sepsis or toxic shock syndrome.

List the two most important hematological features of the Evans syndrome

Evans syndrome is a rare autoimmune disorder, which is characterized by immune thrombocytopenia and autoimmune hemolytic anemia.

Which molecule is targeted by Camrelizumab?

Camrelizumab is a humanised antibody that targets programmed death-1 (PD-1) ligand.

Is MIS-C or Multisystem Inflammatory syndrome in children a complication of Covid-19?

Is MIS-C or Multisystem Inflammatory Syndrome in children a complication of Covid-19? Yes, it is.