hcaoaf/MoleculeQA · Datasets at Hugging Face

text stringlengths 3 799
Option A: It is used as one of the widely used antitussives and to study the involvement of glutamate receptors in neurotoxicity.
Option B: It is useful in research for the selection of animal cells that express the E.
Option C: It is used in contemporary research regarding novel methods to stabilize mesalazine and to decrease inflammatory activity, potentially reducing the risk of colorectal cancer in conditions like ulcerative colitis.
Option D: It has been used to research obesity and energy balance, and exerts some local analgesia effects.
" D
4075 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC(=C(C=C1N)C(=O)O)O
Question about this molecule: How can the molecule be used for research
Option A: It can be conjugated to dyes for confocal microscopy and used to visualize sites of DNA damage. It has been explored for development of antisense oligonucleotides that can be cross-linked specifically to a mutant mRNA sequence without affecting normal transcripts differing at even a single base pair.
Option B: It has been used to research obesity and energy balance, and exerts some local analgesia effects.
Option C: It is used in contemporary research regarding novel methods to stabilize mesalazine and to decrease inflammatory activity, potentially reducing the risk of colorectal cancer in conditions like ulcerative colitis.
Option D: It is used as one of the widely used antitussives and to study the involvement of glutamate receptors in neurotoxicity.
" C
4095 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCC(=O)C(CC(C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2
Question about this molecule: What is the right safety concern information about this molecule?
Option A: The risk appears to be highest in patients with current or past substance use disorders.
Option B: It is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the United States.
Option C: Prolonged use of it may result in dependence.
Option D: It has the capability or risk for eliciting hepatotoxicity in patients.
" C
5486971 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)C[C@@H](CC(=O)O)CN
Question about this molecule: What is the right safety concern information about this molecule?
Option A: It has the capability or risk for eliciting hepatotoxicity in patients.
Option B: It has been withdrawn from the market in Europe and the United States due to the risk of cardiac arrhythmias and overdose, possibly leading to death.
Option C: It is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the United States.
Option D: The risk appears to be highest in patients with current or past substance use disorders.
" D
2313 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=N2)OCC(=O)O
Question about this molecule: What is the right safety concern information about this molecule?
Option A: It is generally considered a lower-risk opioid option for the treatment of moderate to severe pain due to its good tolerability profile and multimodal mechanism of action.
Option B: It has the capability or risk for eliciting hepatotoxicity in patients.
Option C: It has been withdrawn from the market in Europe and the United States due to the risk of cardiac arrhythmias and overdose, possibly leading to death.
Option D: It is associated with a potential reduction in corneal sensitivity accompanied by an increased risk of superficial punctate keratitis and subjective symptoms of discomfort.
" B
9395 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCOP(=O)(OCC)OC1=CC=C(C=C1)[N+](=O)[O-]
Question about this molecule: What is the right safety concern information about this molecule?
Option A: The harms are generally considered to outweigh the small clinical benefit of use of it due to the risk of adverse effects.
Option B: It has been withdrawn from the market in Europe and the United States due to the risk of cardiac arrhythmias and overdose, possibly leading to death.
Option C: It is rarely used as an insecticide due to the risk of poisoning to humans and other animals.
Option D: It is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the United States.
" C
5732 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC=C(C=C1)C2=C(N3C=C(C=CC3=N2)C)CC(=O)N(C)C
Question about this molecule: What is the right safety concern information about this molecule?
Option A: It is generally considered a lower-risk opioid option for the treatment of moderate to severe pain due to its good tolerability profile and multimodal mechanism of action.
Option B: It is associated with a potential reduction in corneal sensitivity accompanied by an increased risk of superficial punctate keratitis and subjective symptoms of discomfort.
Option C: It has a low risk of drug withdrawal, drug dependence, and drug tolerance.
Option D: The harms are generally considered to outweigh the small clinical benefit of use of it due to the risk of adverse effects.
" C
65028 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCC(CC)O[C@@H]1C=C(C[C@@H]([C@H]1NC(=O)C)N)C(=O)OCC
Question about this molecule: What is the right safety concern information about this molecule?
Option A: It is associated with a potential reduction in corneal sensitivity accompanied by an increased risk of superficial punctate keratitis and subjective symptoms of discomfort.
Option B: It has been withdrawn from the market in Europe and the United States due to the risk of cardiac arrhythmias and overdose, possibly leading to death.
Option C: It is generally considered a lower-risk opioid option for the treatment of moderate to severe pain due to its good tolerability profile and multimodal mechanism of action.
Option D: The harms are generally considered to outweigh the small clinical benefit of use of it due to the risk of adverse effects.
" D
271 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: [Ca+2]
Question about this molecule: What is the right safety concern information about this molecule?
Option A: It is generally considered a lower-risk opioid option for the treatment of moderate to severe pain due to its good tolerability profile and multimodal mechanism of action.
Option B: Long-term deficiency of it can lead to osteoporosis and an increased risk of fractures.
Option C: It is associated with a potential reduction in corneal sensitivity accompanied by an increased risk of superficial punctate keratitis and subjective symptoms of discomfort.
Option D: It has been withdrawn from the market in Europe and the United States due to the risk of cardiac arrhythmias and overdose, possibly leading to death.
" B
15130 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC[C@@H](C(C[C@H](C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2)OC(=O)C
Question about this molecule: What is the right safety concern information about this molecule?
Option A: The harms are generally considered to outweigh the small clinical benefit of use of it due to the risk of adverse effects.
Option B: It is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the United States.
Option C: It has been withdrawn from the market in Europe and the United States due to the risk of cardiac arrhythmias and overdose, possibly leading to death.
Option D: It was withdrawn from use in the European Union due to its high risk of QT interval prolongation.
" D
1548943 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)/C=C/CCCCC(=O)NCC1=CC(=C(C=C1)O)OC
Question about this molecule: What is the right safety concern information about this molecule?
Option A: Patients treated with lorcaserin may have a higher risk of cancer.
Option B: It is generally considered a lower-risk opioid option for the treatment of moderate to severe pain due to its good tolerability profile and multimodal mechanism of action.
Option C: It has been withdrawn from the market in Europe and the United States due to the risk of cardiac arrhythmias and overdose, possibly leading to death.
Option D: Consumers of it were at higher risk for gastric cancer than non-consumers.
" D
2519 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1C=NC2=C1C(=O)N(C(=O)N2C)C
Question about this molecule: What is the right safety concern information about this molecule?
Option A: Consumers of it were at higher risk for gastric cancer than non-consumers.
Option B: Patients treated with lorcaserin may have a higher risk of cancer.
Option C: Pregnant women and chronically ill individuals should exercise restraint in their use of it.
Option D: It is generally considered a lower-risk opioid option for the treatment of moderate to severe pain due to its good tolerability profile and multimodal mechanism of action.
" C
2727 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)Cl
Question about this molecule: What is the right safety concern information about this molecule?
Option A: It is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the United States.
Option B: It has the capability or risk for eliciting hepatotoxicity in patients.
Option C: It has been withdrawn from the market in Europe and the United States due to the risk of cardiac arrhythmias and overdose, possibly leading to death.
Option D: The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals.

Option A: It is used as one of the widely used antitussives and to study the involvement of glutamate receptors in neurotoxicity.

Option B: It is useful in research for the selection of animal cells that express the E.

Option C: It is used in contemporary research regarding novel methods to stabilize mesalazine and to decrease inflammatory activity, potentially reducing the risk of colorectal cancer in conditions like ulcerative colitis.

Option D: It has been used to research obesity and energy balance, and exerts some local analgesia effects.

" D

4075 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: C1=CC(=C(C=C1N)C(=O)O)O

Question about this molecule: How can the molecule be used for research

Option A: It can be conjugated to dyes for confocal microscopy and used to visualize sites of DNA damage. It has been explored for development of antisense oligonucleotides that can be cross-linked specifically to a mutant mRNA sequence without affecting normal transcripts differing at even a single base pair.

Option B: It has been used to research obesity and energy balance, and exerts some local analgesia effects.

Option C: It is used in contemporary research regarding novel methods to stabilize mesalazine and to decrease inflammatory activity, potentially reducing the risk of colorectal cancer in conditions like ulcerative colitis.

Option D: It is used as one of the widely used antitussives and to study the involvement of glutamate receptors in neurotoxicity.

" C

4095 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CCC(=O)C(CC(C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2

Question about this molecule: What is the right safety concern information about this molecule?

Option A: The risk appears to be highest in patients with current or past substance use disorders.

Option B: It is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the United States.

Option C: Prolonged use of it may result in dependence.

Option D: It has the capability or risk for eliciting hepatotoxicity in patients.

" C

5486971 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CC(C)C[C@@H](CC(=O)O)CN

Question about this molecule: What is the right safety concern information about this molecule?

Option A: It has the capability or risk for eliciting hepatotoxicity in patients.

Option B: It has been withdrawn from the market in Europe and the United States due to the risk of cardiac arrhythmias and overdose, possibly leading to death.

Option C: It is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the United States.

Option D: The risk appears to be highest in patients with current or past substance use disorders.

" D

2313 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=N2)OCC(=O)O

Question about this molecule: What is the right safety concern information about this molecule?

Option A: It is generally considered a lower-risk opioid option for the treatment of moderate to severe pain due to its good tolerability profile and multimodal mechanism of action.

Option B: It has the capability or risk for eliciting hepatotoxicity in patients.

Option C: It has been withdrawn from the market in Europe and the United States due to the risk of cardiac arrhythmias and overdose, possibly leading to death.

Option D: It is associated with a potential reduction in corneal sensitivity accompanied by an increased risk of superficial punctate keratitis and subjective symptoms of discomfort.

" B

9395 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CCOP(=O)(OCC)OC1=CC=C(C=C1)[N+](=O)[O-]

Question about this molecule: What is the right safety concern information about this molecule?

Option A: The harms are generally considered to outweigh the small clinical benefit of use of it due to the risk of adverse effects.

Option B: It has been withdrawn from the market in Europe and the United States due to the risk of cardiac arrhythmias and overdose, possibly leading to death.

Option C: It is rarely used as an insecticide due to the risk of poisoning to humans and other animals.

Option D: It is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the United States.

" C

5732 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CC1=CC=C(C=C1)C2=C(N3C=C(C=CC3=N2)C)CC(=O)N(C)C

Question about this molecule: What is the right safety concern information about this molecule?

Option A: It is generally considered a lower-risk opioid option for the treatment of moderate to severe pain due to its good tolerability profile and multimodal mechanism of action.

Option B: It is associated with a potential reduction in corneal sensitivity accompanied by an increased risk of superficial punctate keratitis and subjective symptoms of discomfort.

Option C: It has a low risk of drug withdrawal, drug dependence, and drug tolerance.

Option D: The harms are generally considered to outweigh the small clinical benefit of use of it due to the risk of adverse effects.

" C

65028 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CCC(CC)O[C@@H]1C=C(C[C@@H]([C@H]1NC(=O)C)N)C(=O)OCC

Question about this molecule: What is the right safety concern information about this molecule?

Option A: It is associated with a potential reduction in corneal sensitivity accompanied by an increased risk of superficial punctate keratitis and subjective symptoms of discomfort.

Option B: It has been withdrawn from the market in Europe and the United States due to the risk of cardiac arrhythmias and overdose, possibly leading to death.

Option C: It is generally considered a lower-risk opioid option for the treatment of moderate to severe pain due to its good tolerability profile and multimodal mechanism of action.

Option D: The harms are generally considered to outweigh the small clinical benefit of use of it due to the risk of adverse effects.

" D

271 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: [Ca+2]

Question about this molecule: What is the right safety concern information about this molecule?

Option A: It is generally considered a lower-risk opioid option for the treatment of moderate to severe pain due to its good tolerability profile and multimodal mechanism of action.

Option B: Long-term deficiency of it can lead to osteoporosis and an increased risk of fractures.

Option C: It is associated with a potential reduction in corneal sensitivity accompanied by an increased risk of superficial punctate keratitis and subjective symptoms of discomfort.

Option D: It has been withdrawn from the market in Europe and the United States due to the risk of cardiac arrhythmias and overdose, possibly leading to death.

" B

15130 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CC[C@@H](C(C[C@H](C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2)OC(=O)C

Question about this molecule: What is the right safety concern information about this molecule?

Option A: The harms are generally considered to outweigh the small clinical benefit of use of it due to the risk of adverse effects.

Option B: It is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the United States.

Option C: It has been withdrawn from the market in Europe and the United States due to the risk of cardiac arrhythmias and overdose, possibly leading to death.

Option D: It was withdrawn from use in the European Union due to its high risk of QT interval prolongation.

" D

1548943 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CC(C)/C=C/CCCCC(=O)NCC1=CC(=C(C=C1)O)OC

Question about this molecule: What is the right safety concern information about this molecule?

Option A: Patients treated with lorcaserin may have a higher risk of cancer.

Option B: It is generally considered a lower-risk opioid option for the treatment of moderate to severe pain due to its good tolerability profile and multimodal mechanism of action.

Option C: It has been withdrawn from the market in Europe and the United States due to the risk of cardiac arrhythmias and overdose, possibly leading to death.

Option D: Consumers of it were at higher risk for gastric cancer than non-consumers.

" D

2519 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CN1C=NC2=C1C(=O)N(C(=O)N2C)C

Question about this molecule: What is the right safety concern information about this molecule?

Option A: Consumers of it were at higher risk for gastric cancer than non-consumers.

Option B: Patients treated with lorcaserin may have a higher risk of cancer.

Option C: Pregnant women and chronically ill individuals should exercise restraint in their use of it.

Option D: It is generally considered a lower-risk opioid option for the treatment of moderate to severe pain due to its good tolerability profile and multimodal mechanism of action.

" C

2727 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)Cl

Question about this molecule: What is the right safety concern information about this molecule?

Option A: It is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the United States.

Option B: It has the capability or risk for eliciting hepatotoxicity in patients.

Option C: It has been withdrawn from the market in Europe and the United States due to the risk of cardiac arrhythmias and overdose, possibly leading to death.

Option D: The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals.