hcaoaf/MoleculeQA · Datasets at Hugging Face

text stringlengths 3 799
" D
3121 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCCC(CCC)C(=O)O
Question about this molecule: What is the right safety concern information about this molecule?
Option A: The risk of venous thromboembolism with oral contraceptives such as this molecule exists but remains lower than the risk of this condition during pregnancy and during the postpartum period.
Option B: It can cross the placental barrier during pregnancy, which can result in fetal bleeding, spontaneous abortion, preterm birth, stillbirth, and neonatal death.
Option C: It is generally considered a lower-risk opioid option for the treatment of moderate to severe pain due to its good tolerability profile and multimodal mechanism of action.
Option D: Rarely, serious complications may occur in some patients, including hemorrhagic pancreatitis, coagulopathies, bone marrow suppression, VPA-induced hepatotoxicity and encephalopathy.
" D
887 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CO
Question about this molecule: What is the right safety concern information about this molecule?
Option A: It is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the United States.
Option B: It is rarely used as an insecticide due to the risk of poisoning to humans and other animals.
Option C: It may result in an explosion if large quantities are involved in a fire or if the combustible material is finely divided.
Option D: Any accumulation of vapors in confined spaces may explode if ignited.
" D
784 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: OO
Question about this molecule: What is the right safety concern information about this molecule?
Option A: It is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the United States.
Option B: The risk appears to be highest in patients with current or past substance use disorders.
Option C: It can cause spontaneous combustion when it comes in contact with organic material.
Option D: It is rarely used as an insecticide due to the risk of poisoning to humans and other animals.
" C
5505 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)C
Question about this molecule: What is the right safety concern information about this molecule?
Option A: It is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the United States.
Option B: The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals.
Option C: It has been withdrawn from the market in Europe and the United States due to the risk of cardiac arrhythmias and overdose, possibly leading to death.
Option D: It has the capability or risk for eliciting hepatotoxicity in patients.
" B
3715 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O
Question about this molecule: What is the right safety concern information about this molecule?
Option A: It is associated with a potential reduction in corneal sensitivity accompanied by an increased risk of superficial punctate keratitis and subjective symptoms of discomfort.
Option B: It is generally considered a lower-risk opioid option for the treatment of moderate to severe pain due to its good tolerability profile and multimodal mechanism of action.
Option C: It can cross the placental barrier during pregnancy, which can result in fetal bleeding, spontaneous abortion, preterm birth, stillbirth, and neonatal death.
Option D: The risk of venous thromboembolism with oral contraceptives such as this molecule exists but remains lower than the risk of this condition during pregnancy and during the postpartum period.
" A
23668193 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: N(=O)[O-].[Na+]
Question about this molecule: What is the right safety concern information about this molecule?
Option A: It is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the United States.
Option B: It may result in an explosion if large quantities are involved in a fire or if the combustible material is finely divided.
Option C: Any accumulation of vapors in confined spaces may explode if ignited.
Option D: It is rarely used as an insecticide due to the risk of poisoning to humans and other animals.
" B
5282379 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C\\C(=O)O)/C)/C
Question about this molecule: What is the right safety concern information about this molecule?
Option A: The harms are generally considered to outweigh the small clinical benefit of use of it due to the risk of adverse effects.
Option B: It has been withdrawn from the market in Europe and the United States due to the risk of cardiac arrhythmias and overdose, possibly leading to death.
Option C: It is generally considered a lower-risk opioid option for the treatment of moderate to severe pain due to its good tolerability profile and multimodal mechanism of action.
Option D: It is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the United States.
" D
6432 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C(C(F)(F)F)(C(F)(F)F)(F)F
Question about this molecule: What is the right safety concern information about this molecule?
Option A: It has been withdrawn from the market in Europe and the United States due to the risk of cardiac arrhythmias and overdose, possibly leading to death.
Option B: Asphyxiation may occur because of displacement of oxygen, although the mixture is nonflammable and nontoxic.
Option C: It is generally considered a lower-risk opioid option for the treatment of moderate to severe pain due to its good tolerability profile and multimodal mechanism of action.
Option D: The harms are generally considered to outweigh the small clinical benefit of use of it due to the risk of adverse effects.
" B
33741 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN(C)C[C@H]1CCCC[C@@]1(C2=CC(=CC=C2)OC)O
Question about this molecule: What is the right safety concern information about this molecule?
Option A: The risk of venous thromboembolism with oral contraceptives such as this molecule exists but remains lower than the risk of this condition during pregnancy and during the postpartum period.
Option B: It is associated with a potential reduction in corneal sensitivity accompanied by an increased risk of superficial punctate keratitis and subjective symptoms of discomfort.
Option C: It can cross the placental barrier during pregnancy, which can result in fetal bleeding, spontaneous abortion, preterm birth, stillbirth, and neonatal death.
Option D: It is generally considered a lower-risk opioid option for the treatment of moderate to severe pain due to its good tolerability profile and multimodal mechanism of action.
" D
7111 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: C1=CC(=CC=C1C2=CC=C(C=C2)N)N
Question about this molecule: What is the right safety concern information about this molecule?
Option A: Patients treated with lorcaserin may have a higher risk of cancer.
Option B: Occupational exposure to this molecule results in an increased risk of bladder cancer.
Option C: Consumers of it were at higher risk for gastric cancer than non-consumers.
Option D: It has been withdrawn from the market in Europe and the United States due to the risk of cardiac arrhythmias and overdose, possibly leading to death.
" B
54678486 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(=O)CC(C1=CC=CC=C1)C2=C(C3=CC=CC=C3OC2=O)O
Question about this molecule: What is the right safety concern information about this molecule?
Option A: It is generally considered a lower-risk opioid option for the treatment of moderate to severe pain due to its good tolerability profile and multimodal mechanism of action.
Option B: It can cross the placental barrier during pregnancy, which can result in fetal bleeding, spontaneous abortion, preterm birth, stillbirth, and neonatal death.
Option C: The risk of venous thromboembolism with oral contraceptives such as this molecule exists but remains lower than the risk of this condition during pregnancy and during the postpartum period.
Option D: Rarely, serious complications may occur in some patients, including hemorrhagic pancreatitis, coagulopathies, bone marrow suppression, VPA-induced hepatotoxicity and encephalopathy.
" B
47811 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCCN1C[C@@H](C[C@H]2[C@H]1CC3=CNC4=CC=CC2=C34)CSC
Question about this molecule: What is the right safety concern information about this molecule?
Option A: It has been withdrawn from the market in Europe and the United States due to the risk of cardiac arrhythmias and overdose, possibly leading to death.
Option B: The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals.
Option C: It increased the risk of cardiac valvulopathy.
Option D: It has effects on increased serum potassium levels, and is associated with a risk of producing hyperkalemia.
" C
10100 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCC(=O)O[C@](CC1=CC=CC=C1)(C2=CC=CC=C2)[C@H](C)CN(C)C
Question about this molecule: What is the right safety concern information about this molecule?

" D

3121 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CCCC(CCC)C(=O)O

Question about this molecule: What is the right safety concern information about this molecule?

Option A: The risk of venous thromboembolism with oral contraceptives such as this molecule exists but remains lower than the risk of this condition during pregnancy and during the postpartum period.

Option B: It can cross the placental barrier during pregnancy, which can result in fetal bleeding, spontaneous abortion, preterm birth, stillbirth, and neonatal death.

Option C: It is generally considered a lower-risk opioid option for the treatment of moderate to severe pain due to its good tolerability profile and multimodal mechanism of action.

Option D: Rarely, serious complications may occur in some patients, including hemorrhagic pancreatitis, coagulopathies, bone marrow suppression, VPA-induced hepatotoxicity and encephalopathy.

" D

887 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CO

Question about this molecule: What is the right safety concern information about this molecule?

Option A: It is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the United States.

Option B: It is rarely used as an insecticide due to the risk of poisoning to humans and other animals.

Option C: It may result in an explosion if large quantities are involved in a fire or if the combustible material is finely divided.

Option D: Any accumulation of vapors in confined spaces may explode if ignited.

" D

784 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: OO

Question about this molecule: What is the right safety concern information about this molecule?

Option A: It is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the United States.

Option B: The risk appears to be highest in patients with current or past substance use disorders.

Option C: It can cause spontaneous combustion when it comes in contact with organic material.

Option D: It is rarely used as an insecticide due to the risk of poisoning to humans and other animals.

" C

5505 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CCCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)C

Question about this molecule: What is the right safety concern information about this molecule?

Option A: It is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the United States.

Option B: The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals.

Option C: It has been withdrawn from the market in Europe and the United States due to the risk of cardiac arrhythmias and overdose, possibly leading to death.

Option D: It has the capability or risk for eliciting hepatotoxicity in patients.

" B

3715 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O

Question about this molecule: What is the right safety concern information about this molecule?

Option A: It is associated with a potential reduction in corneal sensitivity accompanied by an increased risk of superficial punctate keratitis and subjective symptoms of discomfort.

Option B: It is generally considered a lower-risk opioid option for the treatment of moderate to severe pain due to its good tolerability profile and multimodal mechanism of action.

Option C: It can cross the placental barrier during pregnancy, which can result in fetal bleeding, spontaneous abortion, preterm birth, stillbirth, and neonatal death.

Option D: The risk of venous thromboembolism with oral contraceptives such as this molecule exists but remains lower than the risk of this condition during pregnancy and during the postpartum period.

" A

23668193 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: N(=O)[O-].[Na+]

Question about this molecule: What is the right safety concern information about this molecule?

Option A: It is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the United States.

Option B: It may result in an explosion if large quantities are involved in a fire or if the combustible material is finely divided.

Option C: Any accumulation of vapors in confined spaces may explode if ignited.

Option D: It is rarely used as an insecticide due to the risk of poisoning to humans and other animals.

" B

5282379 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C\\C(=O)O)/C)/C

Question about this molecule: What is the right safety concern information about this molecule?

Option A: The harms are generally considered to outweigh the small clinical benefit of use of it due to the risk of adverse effects.

Option B: It has been withdrawn from the market in Europe and the United States due to the risk of cardiac arrhythmias and overdose, possibly leading to death.

Option C: It is generally considered a lower-risk opioid option for the treatment of moderate to severe pain due to its good tolerability profile and multimodal mechanism of action.

Option D: It is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the United States.

" D

6432 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: C(C(F)(F)F)(C(F)(F)F)(F)F

Question about this molecule: What is the right safety concern information about this molecule?

Option A: It has been withdrawn from the market in Europe and the United States due to the risk of cardiac arrhythmias and overdose, possibly leading to death.

Option B: Asphyxiation may occur because of displacement of oxygen, although the mixture is nonflammable and nontoxic.

Option C: It is generally considered a lower-risk opioid option for the treatment of moderate to severe pain due to its good tolerability profile and multimodal mechanism of action.

Option D: The harms are generally considered to outweigh the small clinical benefit of use of it due to the risk of adverse effects.

" B

33741 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CN(C)C[C@H]1CCCC[C@@]1(C2=CC(=CC=C2)OC)O

Question about this molecule: What is the right safety concern information about this molecule?

Option A: The risk of venous thromboembolism with oral contraceptives such as this molecule exists but remains lower than the risk of this condition during pregnancy and during the postpartum period.

Option B: It is associated with a potential reduction in corneal sensitivity accompanied by an increased risk of superficial punctate keratitis and subjective symptoms of discomfort.

Option C: It can cross the placental barrier during pregnancy, which can result in fetal bleeding, spontaneous abortion, preterm birth, stillbirth, and neonatal death.

Option D: It is generally considered a lower-risk opioid option for the treatment of moderate to severe pain due to its good tolerability profile and multimodal mechanism of action.

" D

7111 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: C1=CC(=CC=C1C2=CC=C(C=C2)N)N

Question about this molecule: What is the right safety concern information about this molecule?

Option A: Patients treated with lorcaserin may have a higher risk of cancer.

Option B: Occupational exposure to this molecule results in an increased risk of bladder cancer.

Option C: Consumers of it were at higher risk for gastric cancer than non-consumers.

Option D: It has been withdrawn from the market in Europe and the United States due to the risk of cardiac arrhythmias and overdose, possibly leading to death.

" B

54678486 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CC(=O)CC(C1=CC=CC=C1)C2=C(C3=CC=CC=C3OC2=O)O

Question about this molecule: What is the right safety concern information about this molecule?

Option A: It is generally considered a lower-risk opioid option for the treatment of moderate to severe pain due to its good tolerability profile and multimodal mechanism of action.

Option B: It can cross the placental barrier during pregnancy, which can result in fetal bleeding, spontaneous abortion, preterm birth, stillbirth, and neonatal death.

Option C: The risk of venous thromboembolism with oral contraceptives such as this molecule exists but remains lower than the risk of this condition during pregnancy and during the postpartum period.

Option D: Rarely, serious complications may occur in some patients, including hemorrhagic pancreatitis, coagulopathies, bone marrow suppression, VPA-induced hepatotoxicity and encephalopathy.

" B

47811 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CCCN1C[C@@H](C[C@H]2[C@H]1CC3=CNC4=CC=CC2=C34)CSC

Question about this molecule: What is the right safety concern information about this molecule?

Option A: It has been withdrawn from the market in Europe and the United States due to the risk of cardiac arrhythmias and overdose, possibly leading to death.

Option B: The risk of hypoglycemia is increased in elderly, debilitated and malnourished individuals.

Option C: It increased the risk of cardiac valvulopathy.

Option D: It has effects on increased serum potassium levels, and is associated with a risk of producing hyperkalemia.

" C

10100 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CCC(=O)O[C@](CC1=CC=CC=C1)(C2=CC=CC=C2)[C@H](C)CN(C)C

Question about this molecule: What is the right safety concern information about this molecule?