hcaoaf/MoleculeQA · Datasets at Hugging Face

text stringlengths 3 799
Option A: The harms are generally considered to outweigh the small clinical benefit of use of it due to the risk of adverse effects.
Option B: It has been withdrawn from the market in Europe and the United States due to the risk of cardiac arrhythmias and overdose, possibly leading to death.
Option C: It is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the United States.
Option D: It is generally considered a lower-risk opioid option for the treatment of moderate to severe pain due to its good tolerability profile and multimodal mechanism of action.
" B
10180 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCN(CC)CCNC1=C2C(=C(C=C1)C)SC3=CC=CC=C3C2=O
Question about this molecule: What is the right testing information about this molecule?
Option A: Sensitivity to Methylchloroisothiazolinone may be identified with a clinical patch test.
Option B: Patients eligible for this treatment are selected by testing the presence of IDH2 mutations in the blood or bone marrow.
Option C: Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver.
Option D: It is currently being tested as a radiation sensitizer.
" D
2206 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=CC(=O)N(N1C)C2=CC=CC=C2
Question about this molecule: What is the right testing information about this molecule?
Option A: Sensitivity to Methylchloroisothiazolinone may be identified with a clinical patch test.
Option B: Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver.
Option C: Patients eligible for this treatment are selected by testing the presence of IDH2 mutations in the blood or bone marrow.
Option D: It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of cushing syndrome.
" B
33344 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CN1C(=O)C=C(S1)Cl
Question about this molecule: What is the right testing information about this molecule?
Option A: Patients eligible for this treatment are selected by testing the presence of IDH2 mutations in the blood or bone marrow.
Option B: Sensitivity to Methylchloroisothiazolinone may be identified with a clinical patch test.
Option C: Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver.
Option D: It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of cushing syndrome.
" B
281 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: [C-]#[O+]
Question about this molecule: What is the right testing information about this molecule?
Option A: It is currently being tested as a radiation sensitizer.
Option B: Patients eligible for this treatment are selected by testing the presence of IDH2 mutations in the blood or bone marrow.
Option C: Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver.
Option D: The DLCO test is both convenient and simple for the patient to undergo.
" D
119570 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCCN[C@H]1CCC2=C(C1)SC(=N2)N
Question about this molecule: How can the molecule be used for therapeutic use
Option A: It is efficacious in treating various Parkinson's symptoms such as tremor, rigidity, and bradykinesia (slow movement).
Option B: It is used for the treatment of allergic conditions such as pruritus, urticaria, dermatoses, and histamine-mediated pruritus.
Option C: It can be used for the therapy of leprosy and dermatitis herpetiformis.
Option D: It is commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta blockers.
" A
2520 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC
Question about this molecule: How can the molecule be used for therapeutic use
Option A: It is used for treatment of hypertension, angina pectoris and superventricular tachyarrhythmias.
Option B: It can be used for the therapy of leprosy and dermatitis herpetiformis.
Option C: It can be used to treat hypertension and angina pectoris.
Option D: It can be used in the therapy of hypertension and angina pectoris.
" A
1548887 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC\\1=C(C2=C(/C1=C\\C3=CC=C(C=C3)S(=O)C)C=CC(=C2)F)CC(=O)O
Question about this molecule: How can the molecule be used for therapeutic use
Option A: It is used in the treatment of acute pain and chronic arthritis.
Option B: It is used for the therapy of chronic arthritis.
Option C: It is used in therapy of chronic arthritis.
Option D: It is used predominantly to treat chronic arthritis.
" D
208898 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCCCC1=C(C2=C(O1)C=CC(=C2)NS(=O)(=O)C)C(=O)C3=CC=C(C=C3)OCCCN(CCCC)CCCC
Question about this molecule: How can the molecule be used for therapeutic use
Option A: It is efficacious in treating various Parkinson's symptoms such as tremor, rigidity, and bradykinesia (slow movement).
Option B: It restores the motor disturbances induced by neuroleptics, in particular the hyperkinesia.
Option C: It works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation.
Option D: It can be used for the therapy of leprosy and dermatitis herpetiformis.
" C
25154714 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(C)[C@@H](C(=O)N1CCC[C@H]1C2=NC=C(N2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C(N5)[C@@H]6CCCN6C(=O)[C@H](C(C)C)NC(=O)OC)NC(=O)OC
Question about this molecule: How can the molecule be used for therapeutic use
Option A: It can be used as first-line therapy in patients with genotype 3 without cirrhosis and second-line therapy in genotype 3 patients with compensated cirrhosis.
Option B: It is used for the treatment of allergic conditions such as pruritus, urticaria, dermatoses, and histamine-mediated pruritus.
Option C: It is used in the therapy of edema, particularly in patients with cirrhosis in which hyperaldosteronism appears to play a major role.
Option D: It can be used for the therapy of leprosy and dermatitis herpetiformis.
" A
5291 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5
Question about this molecule: How can the molecule be used for therapeutic use
Option A: It can be used in combination with other agents as therapy of tuberculosis, particularly in once or twice weekly regimens.
Option B: It can lead to complete hematologic responses in patients with CML.
Option C: It provides a new and promising therapy for the treatment of PPD in adult females.
Option D: It can be used as therapy, both oral and intravenous, in human health and disease.
" B
92786 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@@H]4[C@@]3(CC[C@H](C4)O)C)C
Question about this molecule: How can the molecule be used for therapeutic use
Option A: It is commonly used as a first line therapy in the treatment of hypertension.
Option B: It provides a new and promising therapy for the treatment of PPD in adult females.
Option C: It is used for the treatment of hypertension.
Option D: It is marketed for the treatment of hypertension.
" B
4095 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.
Molecule SMILES: CCC(=O)C(CC(C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2
Question about this molecule: How can the molecule be used for therapeutic use
Option A: It is used for the treatment of hypertension.
Option B: It is used for the treatment of opioid addiction.
Option C: It is used for the treatment of schizophrenia symptoms.
Option D: It is used in the treatment of schizophrenia in adult patients.

Option A: The harms are generally considered to outweigh the small clinical benefit of use of it due to the risk of adverse effects.

Option B: It has been withdrawn from the market in Europe and the United States due to the risk of cardiac arrhythmias and overdose, possibly leading to death.

Option C: It is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the United States.

Option D: It is generally considered a lower-risk opioid option for the treatment of moderate to severe pain due to its good tolerability profile and multimodal mechanism of action.

" B

10180 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CCN(CC)CCNC1=C2C(=C(C=C1)C)SC3=CC=CC=C3C2=O

Question about this molecule: What is the right testing information about this molecule?

Option A: Sensitivity to Methylchloroisothiazolinone may be identified with a clinical patch test.

Option B: Patients eligible for this treatment are selected by testing the presence of IDH2 mutations in the blood or bone marrow.

Option C: Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver.

Option D: It is currently being tested as a radiation sensitizer.

" D

2206 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CC1=CC(=O)N(N1C)C2=CC=CC=C2

Question about this molecule: What is the right testing information about this molecule?

Option A: Sensitivity to Methylchloroisothiazolinone may be identified with a clinical patch test.

Option B: Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver.

Option C: Patients eligible for this treatment are selected by testing the presence of IDH2 mutations in the blood or bone marrow.

Option D: It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of cushing syndrome.

" B

33344 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CN1C(=O)C=C(S1)Cl

Question about this molecule: What is the right testing information about this molecule?

Option A: Patients eligible for this treatment are selected by testing the presence of IDH2 mutations in the blood or bone marrow.

Option B: Sensitivity to Methylchloroisothiazolinone may be identified with a clinical patch test.

Option C: Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver.

Option D: It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of cushing syndrome.

" B

281 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: [C-]#[O+]

Question about this molecule: What is the right testing information about this molecule?

Option A: It is currently being tested as a radiation sensitizer.

Option B: Patients eligible for this treatment are selected by testing the presence of IDH2 mutations in the blood or bone marrow.

Option C: Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver.

Option D: The DLCO test is both convenient and simple for the patient to undergo.

" D

119570 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CCCN[C@H]1CCC2=C(C1)SC(=N2)N

Question about this molecule: How can the molecule be used for therapeutic use

Option A: It is efficacious in treating various Parkinson's symptoms such as tremor, rigidity, and bradykinesia (slow movement).

Option B: It is used for the treatment of allergic conditions such as pruritus, urticaria, dermatoses, and histamine-mediated pruritus.

Option C: It can be used for the therapy of leprosy and dermatitis herpetiformis.

Option D: It is commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta blockers.

" A

2520 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC

Question about this molecule: How can the molecule be used for therapeutic use

Option A: It is used for treatment of hypertension, angina pectoris and superventricular tachyarrhythmias.

Option B: It can be used for the therapy of leprosy and dermatitis herpetiformis.

Option C: It can be used to treat hypertension and angina pectoris.

Option D: It can be used in the therapy of hypertension and angina pectoris.

" A

1548887 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CC\\1=C(C2=C(/C1=C\\C3=CC=C(C=C3)S(=O)C)C=CC(=C2)F)CC(=O)O

Question about this molecule: How can the molecule be used for therapeutic use

Option A: It is used in the treatment of acute pain and chronic arthritis.

Option B: It is used for the therapy of chronic arthritis.

Option C: It is used in therapy of chronic arthritis.

Option D: It is used predominantly to treat chronic arthritis.

" D

208898 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CCCCC1=C(C2=C(O1)C=CC(=C2)NS(=O)(=O)C)C(=O)C3=CC=C(C=C3)OCCCN(CCCC)CCCC

Question about this molecule: How can the molecule be used for therapeutic use

Option A: It is efficacious in treating various Parkinson's symptoms such as tremor, rigidity, and bradykinesia (slow movement).

Option B: It restores the motor disturbances induced by neuroleptics, in particular the hyperkinesia.

Option C: It works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation.

Option D: It can be used for the therapy of leprosy and dermatitis herpetiformis.

" C

25154714 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CC(C)[C@@H](C(=O)N1CCC[C@H]1C2=NC=C(N2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C(N5)[C@@H]6CCCN6C(=O)[C@H](C(C)C)NC(=O)OC)NC(=O)OC

Question about this molecule: How can the molecule be used for therapeutic use

Option A: It can be used as first-line therapy in patients with genotype 3 without cirrhosis and second-line therapy in genotype 3 patients with compensated cirrhosis.

Option B: It is used for the treatment of allergic conditions such as pruritus, urticaria, dermatoses, and histamine-mediated pruritus.

Option C: It is used in the therapy of edema, particularly in patients with cirrhosis in which hyperaldosteronism appears to play a major role.

Option D: It can be used for the therapy of leprosy and dermatitis herpetiformis.

" A

5291 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5

Question about this molecule: How can the molecule be used for therapeutic use

Option A: It can be used in combination with other agents as therapy of tuberculosis, particularly in once or twice weekly regimens.

Option B: It can lead to complete hematologic responses in patients with CML.

Option C: It provides a new and promising therapy for the treatment of PPD in adult females.

Option D: It can be used as therapy, both oral and intravenous, in human health and disease.

" B

92786 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@@H]4[C@@]3(CC[C@H](C4)O)C)C

Question about this molecule: How can the molecule be used for therapeutic use

Option A: It is commonly used as a first line therapy in the treatment of hypertension.

Option B: It provides a new and promising therapy for the treatment of PPD in adult females.

Option C: It is used for the treatment of hypertension.

Option D: It is marketed for the treatment of hypertension.

" B

4095 "Please complete the following question answering task: You are given a SMILES of a molecule and a question about it with several options, please analysis the structure of the molecule and choose the right answer for the question from given options.

Molecule SMILES: CCC(=O)C(CC(C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2

Question about this molecule: How can the molecule be used for therapeutic use

Option A: It is used for the treatment of hypertension.

Option B: It is used for the treatment of opioid addiction.

Option C: It is used for the treatment of schizophrenia symptoms.

Option D: It is used in the treatment of schizophrenia in adult patients.