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This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Despite considerable challenges that face the interpretation of clinicoanatomical correlations in neurodegenerative diseases, the current results suggest that at least parts of the left anterior temporal neocortex should be inserted into the temporosylvian language network where they are likely to play critical roles in linking words to their object referents and in sharpening the taxonomic acuity of naming and word comprehension. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | PCA pumps were initiated at St. Jude in 1989. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The results presented support the notion of a complex basis of CVID and related milder PAD disorders, in which an accumulation of multiple genetic and/or environmental factors contributes to the final phenotype.3,15,16 Monogenic defects have only been identified in a minority of cases with CVID.14 Remarkably, some relatives with the same monogenic defect were found to be asymptomatic or suffer from a milder PAD phenotype such as IgGSD 20–23. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In the current study, the parkinsonian rats also demonstrated aberrant tongue movements to process the bolus significantly more than both the young adult and old groups. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Of particularly interest will be behavioral changes and morphological alterations of relevance to mental health disorders such as depression, autism and schizophrenia (Courchesne, Pierce, Schumann, Redcay, Buckwalter, Kennedy, & Morgan, 2007; Eastwood, 2004; Kalia, 2005; Kinney et al 2008; Rapoport, Addington, Frangou, & Psych, 2005). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Moreover, patients prefer an early solid diet rather than a liquid oral diet. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | As indicated above, mechanisms associated with these cortical changes may have significance for the further understanding of and subsequent therapeutic approaches to a number of different mental health disorders. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The enhanced inactivation of V1442E can be explained by a mutation-induced bias in the voltage-dependent motion of IV/S4 toward the outward conformation. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Although Park (2006) focuses on other personal aspects of religion (e.g., intrinsic religiousness), it is likely that the same underlying mechanism is present in the relation between prayer and pain tolerance. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In our study, younger age was associated with worse general QoL, while there was no significant difference in general QoL between female and male participants. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This methodology, once validated in further studies, may be particularly valuable in important patient subpopulations in which empirical dose decisions are especially challenging, such as frail or nonambulatory patient populations with very low serum creatinine values and corresponding uncertainty in estimated creatinine clearance. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This inflammation-tradeoff hypothesis for explaining the dual burden paradox is supported by several lines of evidence, including the ubiquity of recurrent inflammation among children in the developing world (16), the increased deposition of immunologically important central body fat (56) during both chronic inflammation and stunting (51, 57), and the negative effect of proinflammatory cytokines on circulating levels of insulin-like growth factor-1 (58), itself critical in promoting fat oxidation (59). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our results provide potentially useful information of postoperative pain characteristics in the 2 surgical methods. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The potential interaction between gliadin and HLA genotype is being assessed in a randomized, controlled trial of gluten-containing vs. gluten-free diets (citation). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The short chain fatty acid butyrate may beneficially affect metabolic and inflammatory processes and, thus, obesity, diabetes and inflammatory bowel diseases [36,37]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | It is also difficult to repeat the scan in the same imaging session if the acquisition is aborted or image quality is suboptimal [13]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Aldosterone-induced renal injury has been demonstrated in previous clinical study that a mineralocorticoid receptor inhibitor reduced albuminuria independent of blood pressure reduction [27-29]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This dual burden of poor childhood growth and adult obesity is thought by some to reflect an adaptive adjustment early in life to a “thrifty” metabolic phenotype that promotes fat accumulation to hedge against future energy deficits (17, 53, 55). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Standardizing laboratory techniques has been the focus of working groups such as the Semen Best Practices Working Group at the National Institutes of Health, and will provide much needed guidance for future studies. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Evidence in favor of immunogenetic mechanisms include the observation that, in HLA-DQ8 transgenic mice sensitized to gluten, gliadin exposure led to increased contraction of smooth muscle to electrical field stimulation and carbachol (35). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Wan and coworkers in 2003 showed that the mechanisms of tissue injury related to systemic disorders, such as sepsis, seem to be related to a direct activity induced by circulating mediators with both pro- and anti-inflammatory properties able to interact in a dynamic manner and to induce multiple organ failure [21]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | While the primary aldosteronism patients accompanying chronic Kidney disease still have been demonstrated high serum aldosterone and ARR levels, low PRA, and no clear association of hypokalemia. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | As with our STR-B males, the cryo-anesthesia exposed rats used by Kolb & Cioe were behaviorally tested prior to euthanasia for histological assessments. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We believe that transesophageal echocardiography can provide useful information for medical management and surgical intervention of intracardiac tumors. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The results of this study confirm previous findings on efficacy of other modified pollen allergen extracts [8,25], because highly significant increases in pellitory pollen allergen-specific IgG and IgG4 antibody concentrations were measured after just 1 year of treatment. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | It should be noted that early Ig replacement therapy might interfere with the natural progression of the disease. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In conclusion, the most prevalent arch form in this Saudi sample was the narrow tapered form, followed by the narrow ovoid form. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The intervention strategy that we evaluated was highly effective overall as previously reported and intervention effectiveness did not vary in most of the subgroups we examined for this analysis[citation]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Few studies have explored the association of neighborhood food environments with diabetes. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Based on these findings, two genetic risk scores (GRS63 and GRS16) were developed (15). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Clinicians often follow a “rule-of-thumb” method, in which excessive growth is indicated by crossing major percentile lines on a standard growth chart38. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Moreover, increased PWV is predictive of subsequent cardiovascular events. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | For these reasons, generalizability of findings to settings beyond Australia may be limited. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | No specific long-acting opioid has been conclusively shown to be superior for treating chronic pain (Chou, Clark, & Helfand, 2003). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Non-verbal object associations appeared relatively spared. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our results and those of previous studies suggest that SNPs and point mutations in those gene regions contribute to melanoma tumorigenesis (56). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Only minor improvements in C-statistics (AUC) for all fractures were seen when the GRS63 was added to a base model including age, weight and height but not BMD. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Slow growth and resultant small body size during development may reduce the risk of starvation by lowering somatic maintenance costs (68). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Finally, future studies will also have to investigate how changes in cortical morphology and plasticity may be related to specific endocrine alterations. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Truck drivers have poor healthy eating and physical activity behaviors and high BMIs, largely due to the limitations of their work environment. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Embryos cultured in a high oxygen concentration had fewer cells, perturbed cell signaling and abnormal energy metabolism, indicating a cultured environment-induced differential expression pattern [21]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We found that ECPs had smaller BMI and waist circumference than NECPs. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The inheritance pattern for this case of congenital myasthenic syndrome cannot be unambiguously established. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | To our knowledge there are no data on rates of visual problems by ethnic populations among pre-school children in Hawai‘i. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Anomias caused by pure retrieval failures We used a particularly rigorous definition of retrieval anomia. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Future studies should improve upon these methodological flaws. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In our study, EIT electrodes were placed around the thorax at the level of the xiphoid process, due to its good approximation of global lung behavior18 and due to its avoidance of imaging potential organ movements below the diaphragm[Citation]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Finally, we only revealed correlations between early neuroimaging and later neurodevelopment but did not test the predictive ability of early neuroimaging. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Nowadays, genes regulating the heart development include 4 types: signal, cell adhesion, ion channels molecules and transcription factor. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our findings in IPH and IgGSD patients are compatible with previous published information on milder forms of PAD.9,10,40,41 IPH and IgGSD patients showed an abnormal distribution of naïve and memory B- and T-cell subsets, similar to that observed in CVID patients, albeit to a lesser extent with a block later in B-cell development and a less pronounced T-cell skewing towards memory subsets. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Expenses usually rise steeply after admission, and families face the added burdens of time away from work and accommodation far from home for those who accompany the patient [32]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Abnormal miRNA expression is suspected to promote cellular carcinoma by affecting proliferation, apoptosis, mitosis, and cell-cycle progression46,47. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Proinflammatory cytokines, such as TNF-α, IL-6, and HMGB1, play important roles in the occurrence and development of biological injury and pathological inflammation processes. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Future studies should also focus on various food environment measures to shed light on the causal pathways by which food environment impacts on cardiovascular risk factors. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The quantitative histological data pertaining to SB CD3, CD8, and (tryptase-positive) mast cells (no. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The cortisol responses of young men are more pronounced than are those of young women after psychological stress [29]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | There was only one cognitive test used to assess each cognitive domain, and the tests were administered at a stage of life at which most individuals would not have experienced extensive cognitive decline particularly during the relatively short 6-year follow-up period. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We should also note the absence of ethnic minority status. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | When considered together with E2 under pulsatile cortisol feedback, T opposed several of the main negative effects of E2. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The lack of a correlation between measures of body weight or morphomic measures and aminoglycoside volume of distribution in this study is concerning, given that aminoglycoside doses are frequently calculated to target a specific maximum concentration of drug in serum (Cmax) using weight-based doses and weight-based estimates of volume. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, these kinds of mechanisms are only identifiable in longitudinal studies. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Further, strong support from close friends was associated with lower symptoms of social anxiety among adolescents. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This point was anecdotally illustrated by a patient with semantic PPA who was visited at her home and found capable of making appropriate use of objects similar to those she could not name or define during her clinical evaluation (Mesulam et al, 2009). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Therefore, this group likely did not receive the same additional attention that patients with diabetes received. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The side effects of both medications are minimized by starting at a low dosage and increasing the dose every 3 to 5 days until pain relief is achieved or the maximum dose is reached. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The precise mechanisms responsible for the therapeutic effects of SIT remain a matter of research. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Inaccuracy in GSV calling, with an appreciable frequency of both false positive and false negative calls, results in inflated P-values and an increased rate of false-positive associations (Text S2; Figure S4). |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Yet the costs and added value of large scale donor KIR genotyping would need to be acknowledged and shared amongst the Networks of Donor Centers and their Transplant Center customers. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Isolates within these two PO10s were collected from patients within the same region. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our study has several strengths. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Indeed, apparent seasonality in TB prevalence actually reflected differences in the proportion of older animals present in the population, reaching up to 13·2% in March 2002. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Many of the tests were also the same ones recommended by expert panels 7,10,11. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Secondly, the coroner's form E does not contain the statutory pacemaker question. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The prevalence of vole TB averaged 3·87% from the longitudinal study, and 9·09% from the cross-sectional study at Kielder Forest. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The morphological effect that was selective to STR-B mice in our study and most closely corresponded to the baseline corticosterone levels at PND 7, was the significant decrease in cortical layers II/III thickness, following adult behavioral experience. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | While interpreting the results, this should be considered, especially given that the association of emotion dysregulation (goal difficulties, impulse and limited strategies), dispositional mindfulness (observing and nonjudge) and social support source (classmates, parents and teachers) with social anxiety symptoms in the multiple regression models was small. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | On the other hand, a very small sample of subjects resulted “non-responder” to HBV vaccination after the completion of the second immunization cycle (data not showed). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | No cats or other animals had been identified in or around the building for several years preceding the outbreak. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This study identified deficits in the LOS and SOT tests among our cohort, who were predominantly classified with mild to moderate TBI, and were found to be at chronic stages post-injury. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, unless a mechanism exists to repeatedly reaerosolize the source, fomites are likely to pose a risk even when they are not heavily contaminated, and this view is supported by the general principles that govern the dispersion and settling out of dust particles or sporelike forms (17,37). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Neither straw nor building material is a common source of outbreaks of Q fever. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In the absence of confirmed VTE or ECMO therapy, anticoagulation at treatment dosages can currently not be recommended on a routine basis. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The use of this test on transsexual populations relies on: i) the availability of both female and male norms, ii) the identification of response distortion from the 3 validity scales, and iii) the availability of a specific Masculinity/Femininity clinical scale, which is especially pertinent to the assessment of transgender individuals. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, we did not find differences in the FEV1/FVC and DLCO between the oxandrolone-treated group and the control group. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Another potential explanation is that aberrant methylation associated with age at menarche is unrelated to the methylation changes relevant to breast cancer, or that the association with age at menarche is in fact confounded by other determinants of methylation levels. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our finding that ANP has anti-inflammatory action (i.e., suppression of LPS-induced E-selectin) in vascular endothelial cells in mice is consistent with these studies. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, it is also possible that some important changes taking place in early life and which are associated with age at menarche – in particular nutrition – have a detectable effect on methylation levels. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We recently reported a lower blood requirement per patient (7 units vs 14 units)3 after using a series of blood-saving techniques. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This is important because increased BMI and waist circumference are the most important risk factors for type 2 diabetes [35,36,37]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Patel et al found that density of full service and fast food restaurants within 1000 m buffer was not related with overweight/obese in Delhi, India (Patel et al, 2017). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Phosphoinositide 3 kinase/protein kinase B pathway is a key regulator in which mesoblastema, original cells of heart development in embryo stage, specially express transcription factors in heart[citation]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The proportion of ECPs in the current study was lower than among Spanish elderly individuals with increased risk for cardiovascular diseases [10], US adults who were mostly females and well educated [6] and among US adults who had hypercholesterolemia [9]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Had these cases been re-classified, the assessment of the primary outcome measures would have been unchanged. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The cardboard manufactured by the factory was produced at temperatures that made survival of C. burnetii sporelike forms impossible so customers were not considered to be at increased risk. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Granulomata consist of neutrophils, giant cells, monocyte-derived tissue macrophages, B cells and CD4+CD28− T cells.18 The activation of T cells in an unbalanced Th1 phenotype and maturation of dendritic cells by PR3, exaggerating this Th1 response, have previously highlighted Th1 cells as critical mediators of granuloma pathogenesis in GPA.18,19 Indeed, both CD4+ Th1 and Th17 cells have been implicated as important orchestrators of granulomatous inflammation. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | A growing body of research indicates that immune-mediated, inflammatory, and apoptotic mechanisms may play a role in the pathogenesis of CRS Type 5 [14]. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | There is a clear need for public health professionals to work closely with other disciplines on research, policy, and practice that will lead to joint efforts to meet societal needs. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Eight of the children with a “refer” recommendation had bilateral ametropic risk factors. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Data on these variables were unavailable or inaccurate, and therefore they were not included in the model. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Actually, ARR as screening test in primary aldosteronism is suffering great challenges, the influence not only comes from inherence, but also exterior has been verified. |