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This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The end point was BP\xa0<\xa0140/90\xa0mm Hg at 6-month follow-up. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Higher precision was observed using a modified Cockcroft-Gault equation with skeletal muscle area at L3 (R2= 0.38) or L4 (R2= 0.37) than the standard Cockcroft-Gault equation using lean (R2= 0.23), adjusted (R2= 0.23), or total (R2= 0.22) body weights. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The distribution of MCP-1 -2518 A/G genotypes complied with the Hardy-Weinberg equilibrium both in patient and healthy control groups. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Delays in seeking appropriate healthcare can increase the case fatality of acute febrile illnesses, and circuitous routes of care-seeking can have a catastrophic financial impact upon patients in low-income settings. 51% of participants were classified as multidimensionally poor (MPI>0.33). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This test detects in a timely manner newborns at risk for invasive GBS disease. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Responders are randomized to 26 weeks of double-blind continuation treatment with 3 x 300 mg/day WS 5570 or placebo. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We retrospectively reviewed the specificity of antibodies against C. trachomatis, Chlamydia psittaci, and Chlamydophila pneumoniae by microimmunofluorescence (MIF) when compared with DFA, culture, nucleic acid probe, and transcription-mediated amplification. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In the analyses of calculated risk score, BMI ‚â• 28.0 corresponded to the highest risk score of 23 points. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This retrospective study included adult patients treated with gentamicin or tobramycin with at least three drug concentrations and computed tomography (CT) imaging available. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The relative risk strength of disease based on genetic variant was revealed using odds ratio (OR) with 95% confidence interval (95%CI). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Those carrying the G allele (AG\u2009+\u2009GG) along with high lutein/zeaxanthin consumption were markedly associated with a decreased colorectal cancer risk (OR, 95% CI\u2009=\u20090.32, 0.22-0.46, P for interaction\u2009=\u20090.018), particularly for rectal cancer (OR, 95% CI\u2009=\u20090.24, 0.15-0.39, P for interaction\u2009=\u20090.004), compared with that of AA carriers with low lutein/zeaxanthin intakes. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | With improvements in diagnostic modalities such as functional imaging, oligometastatic prostate cancer is being diagnosed with greater frequency than ever before. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Furthermore, MCP-1 -2518 GG homozygotes were similarly represented among SSc patients and healthy subjects (P > .05). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | To investigate the outbreak a cohort and nested case-control study of persons who had worked at a cardboard manufacturing plant was conducted. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Pursuing this clue, we sequenced SCN4A encoding the skeletal muscle sodium channel (Nav1.4) and detected two heteroallelic mutations involving conserved residues not present in 400 normal alleles: S246L in the S4/S5 cytoplasmic linker in domain I, and V1442E in the S3/S4 extracellular linker in domain IV. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In a cross-sectional study, 27 sites were monitored bi-annually, with TB assessed by post-mortem examination for macroscopic lesions, and by culture and histopathology. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our results underline the cytotoxic effect of CRS Type 5 mediators on RTC viability, probably due to the activation of both intrinsic and extrinsic pathways of apoptosis and to the deregulation of cytokine release. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The use of vibrating insoles significantly reduced stride, stance, and swing time variability measures for elderly recurrent fallers. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In the previous study, we had showed the expression of CD133+ CD54+ CD44+ cellular subpopulation of circulating tumor cells (CTCs) was significantly associated with liver metastasis of colorectal cancer (CRC). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Because of the explosive potential of pacemakers when heated, a statutory question on the cremation form asks whether the deceased has a pacemaker and if so whether it has been removed. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The mean neutrophil counts, CRP levels, and NLR in both the patients with histologic chorioamnionitis (HCA) alone and those with HCA with funisitis were significantly higher than those in women with no placental inflammation. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This cross-sectional study was conducted in a French public university hospital. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We conducted a retrospective cohort study of 483 patients who delivered preterm neonates. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | After controlling for blood HIV-1 RNA level, seminal plasma HIV-1 RNA level was positively associated with interferon (IFN)-γ (p=0.03) and interleukin (IL)-17 (p=0.03) and negatively associated with IL-5 (p=0.0007) in seminal plasma. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Despite the efficacy of aprotinin and epsilon-aminocaproic acid shown in the present study, the blood requirements were not significantly different from those that are found when transfusions are restricted, autotransfusions are used, and blood from the operative field and extracorporeal circuit is concentrated and reinfused. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Both poor and non-poor households relied predominantly upon the (often informal) private sector for medical advice before reaching the referral hospital, but MPI poor participants were less likely to have consulted a qualified doctor. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | These advantages result in a clinically smoother course after the operation. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our aim was to study in vitro effects of CRS Type 5 plasma on renal tubular cells (RTCs), in terms of cellular death and the characterization of inflammatory plasma profile in these patients. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | CONCLUSIONS Hysterectomy should be performed at least 4 weeks after conization. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Similar to other medical societies, the Society of Thrombosis and Haemostasis Research has issued empirical recommendations on initiation, dosing, and duration of pharmacological VTE prophylaxis in COVID-19 patients. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | A total of 335 patients were included with a median (minimum, maximum) of 4 (3, 16) aminoglycoside concentrations per patient. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | During the 2011-2013 period, an observational study was performed in Healthcare students (HCSs) trained at a regional university acute-care hospital in North-Western Italy, properly immunized against HBV during infancy or adolescence, in order to evaluate the persistence of seroprotection and to assess the anamnestic response to booster vaccination. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Few studies assess built environment correlates of active commuting in low-and-middle-income countries (LMICs), but the different context could yield distinct findings. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Hierarchical linear modeling (HLM) was used to examine the effect of condition (therapeutic communal living versus usual aftercare) on wave trajectories of tolerance (i.e., universality/diversity scores). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We cultured human podocytes with sera collected from DKD patients, who displayed elevated TNF levels, and focal segmental glomerulosclerosis (FSGS) patients, whose TNF levels resembled those of healthy patients. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Further investigation in breast and other cancers are needed to understand the influence of inherited variation in mitotic genes on tumor grade and cancer risk. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Angiogenesis is a key process in the pathogenesis of inflammatory arthritis. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The epidemic curve and other data suggested an outbreak source likely occurred August 5-9, 2002. ', "Employees in the factory's offices were at greatest risk for infection (odds ratio 3.46; 95% confidence interval 1.38-9.06). ", 'The offices were undergoing renovation work around the time of likely exposure and contained straw board that had repeatedly been drilled. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We also attempted replication using BMI as a quantitative trait in our population cohort; associations with BMI at or near nominal significance were detected at two further loci near KIF2B and within FOXP2, but these did not survive correction for multiple testing. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | By contrast, significantly higher serum aldosterone and plasma renin were observed in CKDs compared with the other two groups (P < 0.001). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | At 5 years, children with stable high-BMIz or rapid BMIz gain trajectories had increased waist-to-height ratios [B(95%CI) 0.02(0.01,0.03) and 0.03(0.02,0.04)], sum of skinfolds [0.42(0.19,0.65) and 0.70(0.36,1.03)SD units], fat-mass index [0.97(0.32,1.63)SD units] and risk of obesity [relative risk 3.22(1.73,6.05) and 2.56 (1.19,5.53)], but not higher blood pressure. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | TNF-stimulated free cholesterol-dependent apoptosis in podocytes was mediated by nuclear factor of activated T cells 1 (NFATc1). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The ZCWPW1 (rs1476679) and CDS33 (rs3865444) variants were nominally associated with change on the DWRT and WFT in African-Americans. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Of the 13 patients who had a positive C. trachomatis antigen or nucleic acid test result, 9 had IgG and/or IgM titers highest against C. trachomatis, 3 had IgG titers highest against C. pneumoniae, and 1 had undetectable titers for the three chlamydial species. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Findings can guide public education to improve the safety aspects of self-medication with analgesics in dental practice. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The algorithm also provides several predictions testable in animal/human experiments. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Recovery from an acute episode is followed by 4-6 months of relapse prevention. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | From an epidemiological investigation of 49 E.\xa0coli ST410 isolates from Danish patients, we identified five possible regional outbreaks, of which one outbreak involved nine patients with blaOXA-181- and blaNDM-5-carrying B4/H24RxC isolates. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We sought to decrease DUP in rural Argentina by instituting annual training of local health agents to better identify signs of mental illness and offer earlier intervention. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our data indicate that LMC and STR males share with environmentally enriched males, an increase in thickness in infra-granular cortical layers, while STR also display a stress selective decrease in supragranular layers, in response to behavioral training as adults. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This study sought to establish comprehensive characterization of the fatal vasculopathy in Hutchinson-Gilford progeria syndrome and its relevance to normal aging. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Effective disease treatments may be heralded by normalizing trends of these noninvasive cardiovascular measures. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This was a prospective, observational study of paired blood and semen samples from 18 HIV-1 chronically infected men off antiretroviral therapy. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Therefore, we compared the postoperative numerical rating scale (NRS) of pain intensity between patients who underwent LPN and those who underwent RAPN.We included 705 patients who underwent either LPN (n\u200a=\u200a200) or RAPN (n\u200a=\u200a505) for renal tumors between January 2000 and September 2016. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Correlation of serologic titers for Chlamydia trachomatis with other tests has been based on direct fluorescence antibody (DFA) testing and culture, but not on nucleic acid-based tests that are used for screening. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | These results highlight that skeletal muscle measurements from CT images obtained in the course of care can improve the precision of aminoglycoside CL estimation over current body size scalars. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The measured parameters were arch length, arch width, Bolton's ratio, and arch form. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Nevertheless, we show that such studies are potentially valuable for the identification of variants making an appreciable contribution to complex disease. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In this study, we investigated whether hydration with sodium bicarbonate is superior to hydration with saline in addition to theophylline (both groups) in the prophylaxis of contrast-induced nephropathy (CIN). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In fully adjusted models, higher density of fruit/vegetable vendors within 400\u202fm of participant households was associated with lower systolic blood pressure [-0.09\u202fmmHg, 95% confidence interval (CI): -0.17, -0.02] and diastolic blood pressure (-0.10\u202fmmHg, 95% CI: -0.17, -0.04). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This study suggests a link between age at menarche and genome wide DNA methylation, and the difference in results between the two arrays suggests that repetitive element methylation has a role in the association. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Specifically, degree of stress is positively correlated with likelihood of being diagnosed with this condition and increasing the severity. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Both standard and morphomic measures poorly explained variability in volume (R2 < 0.06). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Significant attention has been given to the ExPEC sequence type ST131, which has been categorized as a "high-risk" clone. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Angiogenin is one of the most potent inducers of neovascularization in experimental models in vivo. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The present study tests this hypothesis across diverse timeframes, branches of immunity, and conditions of energy availability among humans. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Nor were survival outcomes significantly different in the subgroups of patients with or without ALT/AST increases or with ALT/AST elevations ‚â• 15 √ó the upper limit of normal (ULN) versus those with ALT/AST elevation < 15\u2009√ó\u2009ULN. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Thirty (56.6%) patients tolerated an early oral diet well within 24 h postoperatively; in 48 (90.6%) patients, mobilization in the first 24 hours was successful. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We believe that transesophageal echocardiography offers the cardiologist and cardiovascular surgeon the capability of more accurate preoperative and intraoperative assessment of cardiac masses. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Cortical volumes in these areas were reduced to less than half of control values, whereas average volume elsewhere in the left hemisphere deviated from control values by only 8%. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The PEEP was titrated and increased in a 2-cm H2O stepwise manner, from 6 to 14\u200acm H2O. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We performed a case-control study in patients admitted to the hospital with first stroke and community control subjects. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We present the rationale and design of an ongoing double-blind, randomized, placebo-controlled trial investigating the efficacy of Hypericum extract WS 5570 in relapse prevention in recurrent unipolar depression. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The study found that individuals who practised self-medication had stronger beliefs about the benefits of medicines and weaker beliefs in viewing medicines as harmful and overused. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Three patients had osteomalacia confirmed on bone biopsy, two of whom had characteristic biochemistry. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Two outstanding questions in this scheme are "in which directions the search tree should be expanded?", and "when should the expansion stop?". |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The aim of the study is to present clinical outcomes of patients with gastric cancer undergoing laparoscopic gastrectomy combined with the ERAS protocol. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | TBSS analyses showed widespread clusters in major white matter tracts, with positive correlations (P ≤ .05, corrected for the voxel-wise multiple comparisons) between FA values and multiple BSID subscale scores. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Surprisingly many of the naming errors reflected pure retrieval failures, without discernible semantic or associative component. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The cohort included 282 employees and subcontractors, of whom 253 (90%) provided blood samples and 214 (76%) completed questionnaires. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Conversely, the frequency of the SLC4A1Delta27 allele was higher in Liksul (0.0740) than the Wosera (0.0005) (chi(2); P < 0.0001). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | BMIz trajectories were more predictive of adiposity at 5 years than was BMIz at 2 years. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | ABCA1 overexpression or cholesterol depletion was sufficient to reduce albuminuria in mice with podocyte-specific NFATc1 activation. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Although testosterone and SHBG concentrations were associated with breast cancer risk, the concentrations of these hormones were correlated with those of oestradiol; the associations were not statistically significant after adjusting for oestradiol concentration. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Hypertension was defined as mean systolic blood pressure (SBP) and/or diastolic blood pressure (DBP) ‚â•140/90 mm Hg and/or taking anti-hypertensive medication. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Results Thirty-eight full-term infants (20 boys, 18 girls) underwent MRI examination at 2 weeks of age (14.3 days ± 1.6) and BSID measurement at 2 years of age (732 days ± 6). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | It is, however, associated with a relatively high risk of perioperative complications. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Whereas common variable immunodeficiency has been investigated in depth, there are only a few reports on milder primary antibody deficiencies such as idiopathic primary hypogammaglobulinemia and IgG subclass deficiency. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The effect of the intervention was significantly larger in patients who were younger (interaction P\xa0=\xa0.02), did not have diabetes (P\xa0=\xa0.005), had high baseline diastolic BP (P\xa0=\xa0.02), added salt less than daily in food preparation (P\xa0=\xa0.007), and took 0-2 (rather than 3-6) antihypertensive medication classes at baseline (P\xa0=\xa0.02). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | To look for evidence that angiogenin is involved in inflammatory joint disease, we examined plasma and synovial fluid (SF) samples from rheumatology patients and synovial fibroblast cell culture supernatants. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Moreover, the differences among stroke subtypes remain unclear. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Although regression analysis revealed that both tests significantly predicted subjective scores on the DHI, more LOS than SOT testing variables were important predictors of DHI results indicating disability. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We investigated whether dietary lutein/zeaxanthin intake affects colorectal cancer risk in patients with a DICER1 rs3742330 polymorphism. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | A total of 7511 patients aged ‚â• 20 years, who underwent thyroidectomy between January 2009 and December 2013 at the Asan Medical Center were retrospectively analyzed. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Through chromatin interaction mapping, we prioritized IFNA7, IFNA10, IFNA16, IFNA17, IFNA14, IFNA6, IFNA21, IFNA4, IFNE and IFNA5; these 10 most significant genes are all involved in immune system and cytokine signaling pathways. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We further show that our algorithm can explain several behavioral patterns in animals and humans, namely the effect of time-pressure on the depth of planning, the effect of reward magnitudes on the direction of planning, and the gradual shift from goal-directed to habitual behavior over the course of training. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The prevalence of self-medication with analgesics was 29.4%, with 95.6% of the participants took analgesics when necessary. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Symptoms of dizziness, unsteadiness, or imbalance have been most frequently attributed to sensory organization problems involving the use of visual, proprioceptive, and/or vestibular information for postural control. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Repeated RTX treatment in these 3 and persistent B cell depletion in the whole cohort was associated with further significant radiological improvement. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Primary care physicians especially works in lower socioeconomic\nconditions have to tell the importance of early diagnosis of breast cancer, and properly explain breast self examination\nand other screening tools. |