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embedding_all-mpnet-base-v2
sequence
embedding_multi-qa-mpnet-base-dot-v1
sequence
embedding_all-MiniLM-L12-v2
sequence
24488743
4results
In the Stranger at the Door procedure , children with a history of institutional care left with a stranger at higher rates than NIG subjects ( @ % vs. @ % ; P < @ ) .
4
176,200
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24488743
4results
Children in the care as usual group left more than NIG subjects ( @ % vs. @ % ; P @ ) .
5
176,201
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24488743
4results
The differences between the foster care group ( @ % ) and the care as usual group and between foster care group and NIG were not significant .
6
176,202
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24488743
4results
In a logistic regression , early disorganized attachment behaviors , baseline developmental quotient , and caregiving quality after randomization contributed to variance at @ months .
7
176,203
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24488743
4results
In the same analysis using only children with a history of institutional care , only disorganized attachment contributed significantly to @-month indiscriminate social behaviors ( Exp -LSB- B -RSB- = @ -LSB- @ % confidence interval : @-@ @ -RSB- ) .
8
176,204
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24488743
1conclusions
Observed socially indiscriminate behaviors at @ months were associated with prolonged exposure to institutional care .
9
176,205
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24488743
1conclusions
Young children raised in conditions of deprivation who fail to develop organized attachments as toddlers are at increased risk for subsequent indiscriminate behaviors .
10
176,206
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25840499
0background
One goal of guideline-based asthma therapy is minimal use of short-acting agonist ( SABA ) medications .
0
176,207
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25840499
0background
Inner-city children with asthma are known to have high SABA use .
1
176,208
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25840499
3objective
To examine factors associated with high SABA use in inner-city children with asthma .
2
176,209
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25840499
2methods
One hundred inner-city children with persistent asthma were enrolled into a randomized controlled trial of an emergency department ( ED ) and home intervention .
3
176,210
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25840499
2methods
All children underwent serologic allergen specific IgE and salivary cotinine testing at the ED enrollment visit .
4
176,211
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25840499
2methods
Pharmacy records for the past @ months were obtained .
5
176,212
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25840499
2methods
Number of SABA fills during the past @ months was categorized into low - to moderate - vs high-use groups .
6
176,213
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25840499
2methods
SABA groups were compared by the number of symptom days and nights , allergen sensitization , and exposures .
7
176,214
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25840499
2methods
Regression models were used to predict high SABA use .
8
176,215
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25840499
4results
Mean number of SABA fills over @ months was @ .
9
176,216
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25840499
4results
Unadjusted bivariate analysis showed that high SABA users were more than @ times more likely to have an asthma hospitalization , almost @ times more likely to have an asthma intensive care unit admission , and more than @ times more likely to have prior specialty asthma care or positive cockroach sensitization than low to moderate SABA users .
10
176,217
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25840499
4results
In the final regression model , for every additional inhaled corticosteroid fill , a child was @ times more likely and a child with positive cockroach sensitization was almost @ times more likely to have high SABA use when controlling for prior intensive care unit admission , receipt of specialty care , child age , and income .
11
176,218
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25840499
1conclusions
Providers should closely monitor SABA and controller medication use , allergen sensitization , and exposures in children with persistent asthma .
12
176,219
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24674053
3objective
To compare the cardiopulmonary effects of intravenous ( IV ) and intramuscular ( IM ) medetomidine and butorphanol with or without MK-@ .
0
176,220
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24674053
2methods
Prospective , randomized experimental cross-over .
1
176,221
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24674053
2methods
Eight purpose-bred beagles ( two females , six males ) , @-@ years old and weighing @ @ kg ( mean SD ) .
2
176,222
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24674053
2methods
All dogs received four different treatments as follows : medetomidine @ g kg ( -@ ) and butorphanol tartrate @ mg kg ( -@ ) IV and IM ( MB ) , and MB combined with MK-@ ,@ g kg ( -@ ) ( MBMK ) IV and IM .
3
176,223
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24674053
2methods
Heart rate ( HR ) , arterial blood pressures ( SAP , MAP , DAP ) , central venous pressure ( CVP ) , cardiac output , respiratory rate ( fR ) , rectal temperature ( RT ) were measured and arterial blood samples were obtained for gas analysis at baseline and at @ , @ , @ , @ , @ and @ minutes after drug administration .
4
176,224
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24674053
2methods
The cardiac index ( CI ) , systemic vascular resistance index ( SVRI ) and oxygen delivery index ( DO@ I ) were calculated .
5
176,225
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24674053
2methods
After the follow-up period atipamezole @ g kg ( -@ ) IM was given to reverse sedation .
6
176,226
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24674053
4results
HR , CI and DO@ I were significantly higher with MBMK after both IV and IM administration .
7
176,227
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24674053
4results
Similarly , SAP , MAP , DAP , CVP , SVRI and RT were significantly lower after MBMK than with MB .
8
176,228
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24674053
4results
There were no differences in fR between treatments , but arterial partial pressure of oxygen decreased transiently after all treatments .
9
176,229
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24674053
4results
Recoveries were uneventful following atipamezole administration after all treatments .
10
176,230
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24674053
1conclusions
MK-@ attenuated the cardiovascular effects of a medetomidine-butorphanol combination after IV and IM administration .
11
176,231
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25011657
3objective
To evaluate adherence to therapy in acne patients using mobile phones and Short Message Service ( SMS ) to communicate .
0
176,232
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25011657
2methods
@ patients were randomly assigned to two groups : the SMS group received @ text messages twice a day for a period of @ weeks ; the control group did not receive any messages .
1
176,233
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25011657
2methods
Before and after @ weeks , the following evaluations were performed in all patients : digital photographs , the Global Acne Grading System , the Dermatology Life Quality Index , the Cardiff Acne Disability Index , the doctor-patient relationship evaluated through the Patient-Doctor Depth-of-Relationship Scale , and the adherence to treatment evaluated by asking patients how many days a week they had followed the therapy .
2
176,234
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25011657
2methods
For statistical analysis we used Student 's t test .
3
176,235
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25011657
4results
The SMS group had a better improvement of all parameters compared to the control group .
4
176,236
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25011657
1conclusions
Adherence and compliance are higher for patients who are included in a strategy of control .
5
176,237
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24440809
0background
Ondansetron , sometimes combined with acustimulation at PC@ ( Neiguan ) , is commonly used for preventing postoperative nausea and vomiting , but PC@ is not the only point that can be used for this purpose .
0
176,238
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24440809
3objective
To evaluate the combined effects of ondansetron and ST@ ( Zusanli ) acupuncture point injection on postoperative vomiting ( POV ) after laparoscopic surgery .
1
176,239
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24440809
2methods
A randomised , patient and assessor-blinded , placebo-controlled clinical study was conducted .
2
176,240
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24440809
2methods
One hundred and sixty patients undergoing laparoscopic surgery were randomly assigned to one of four groups : ( @ ) group P ( placebo-control ) : intravenous normal saline + bilateral non-acupuncture point injection of vitamin B@ ( n = @ ) ; ( @ ) group O ( ondansetron ) : intravenous ondansetron + bilateral ST@ sham injection ( n = @ ) ; ( @ ) group A ( acupuncture point injection ) : intravenous normal saline + bilateral acupuncture point injection at ST@ of vitamin B@ ( n = @ ) ; ( @ ) group C ( combination ) : intravenous ondansetron + bilateral acupuncture point injection at ST@ of vitamin B@ ( n = @ ) .
3
176,241
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24440809
2methods
Interventions were made on arrival at the postanaesthesia care unit .
4
176,242
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24440809
2methods
The primary outcome was the incidence of POV within @ h after the operation .
5
176,243
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24440809
2methods
Secondary outcomes included severity of vomiting , incidence of rescue treatment , patients ' satisfaction and the first anal exsufflation time @ h after the operation .
6
176,244
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24440809
4results
The incidence of POV within @ h postoperative period in each group was P @ % ; O @ % , A @ % and C @ % .
7
176,245
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24440809
4results
Outcomes for all intervention groups were significantly better than that for placebo ( p < @ ) .
8
176,246
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24440809
4results
For the three interventions compared with placebo , the numbers needed to treat ( NNTs ) were O , NNT = @ ; A , NNT = @ and C , NNT = @ .
9
176,247
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24440809
4results
The secondary outcomes also demonstrated greater benefits of the combined regimen , with improvement seen in all the measures .
10
176,248
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24440809
1conclusions
Ondansetron , acupuncture , and ondansetron and acupuncture combined are effective prophylaxis for POV .
11
176,249
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24601726
0background
The impact of sugar-sweetened beverages ( SSB ) on lipid metabolism when consumed in moderate amounts by normal weight subjects is debated .
0
176,250
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24601726
3objective
The objective of the study was to investigate the effect of different types of sugars in SSB on fatty acid metabolism ( ie , fatty acid synthesis and oxidation ) in healthy young men .
1
176,251
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24601726
2methods
Thirty-four normal-weight men were studied in a randomized crossover study .
2
176,252
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24601726
2methods
Four isocaloric @-week interventions with SSB were performed in random order : medium fructose ( MF ; @ g/d ) ; high fructose ( HF ; @ g/d ) , high sucrose ( HS ; @ g/d ) , and high glucose ( HG ; @g/d ) .
3
176,253
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24601726
2methods
Fasting total plasma fatty acid composition was measured after each intervention .
4
176,254
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24601726
2methods
Acylcarnitines were measured in the fasting state and after a euglycemic hyperinsulinemic clamp in nine subjects .
5
176,255
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24601726
4results
The relative abundance of palmitate ( @:@ ) and the molar fatty acid ratio of palmitate to linoleic acid ( @:@ to@ :@ ) as markers of fatty acid synthesis were increased after HF -LSB- relative abundance of palmitate : @ % @ % ( percentage of total fatty acids by weight SD ) -RSB- and MF ( @ % @ % ) compared with HS ( @ % @ % , P < @ ) , HG ( @ % @ % , P < @ ) , or baseline ( @ % @ % , P < @ ) .
6
176,256
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24601726
4results
After HS and HG , the relative abundance of palmitate was equal to baseline .
7
176,257
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24601726
4results
Fasting palmitoylcarnitine was significantly increased after HF and HS ( HF and HS vs. HG : P = @ ) , decreasing after inhibition of lipolysis by insulin in the clamp .
8
176,258
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24601726
1conclusions
When consumed in moderate amounts , fructose but not sucrose or glucose in SSB increases fatty acid synthesis ( palmitate ) , whereas fasting long-chain acylcarnitines are increased after both fructose and sucrose , indicating an impaired - oxidation flux .
9
176,259
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25465830
0background
Little is known about global patterns of critical care unit ( CCU ) care and the relationship with outcomes in patients with acute decompensated heart failure ( ADHF ) .
0
176,260
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25465830
0background
Whether a ward or a CCU admission is associated with better outcomes is unclear .
1
176,261
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25465830
2methods
Patients in the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure ( ASCEND-HF ) trial were initially hospitalized in a ward or CCU ( coronary or intensive care unit ) .
2
176,262
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25465830
2methods
Sites were geographically classified : Asia-Pacific ( AP ) , Central Europe ( CE ) , Latin America ( LA ) , North America ( NA ) , and Western-Europe ( WE ) .
3
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25465830
2methods
The primary outcome of @-day all-cause mortality or all-cause hospital readmission was adjusted using a two-stage multivariable logistic regression model with a generalized estimated equation that took sites within each country as a nested random factor .
4
176,264
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25465830
4results
Overall , @ ( @ % ) patients were admitted to a CCU and @ ( @ % ) to a ward , and this varied by region : @ % AP , @ % CE , @ % WE , @ % LA , and @ % NA .
5
176,265
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25465830
4results
The @-day death or readmission rate was @ % in ward patients and @ % in CCU patients ( risk-adjusted Odds Ratio -LSB- OR -RSB- @ : @ % CI , @-@ @ ) .
6
176,266
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25465830
4results
Compared with CCU patients in NA ( @ % @-day event rate ) , the primary outcomes were : AP ( @ % , Odds Ratio -LSB- OR -RSB- @ ; @ % confidence Interval -LSB- CI -RSB- , @ to @ ) , CE ( @ % , OR @ : @ % CI , @ to @ ) , LA ( @ % , OR @ : @ % CI , @ to @ ) , and WE ( @ % , OR @ , @ % CI , @ to @ ) .
7
176,267
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25465830
4results
No regional differences in @-day mortality were observed ; however , @-day readmission rates were highest in NA sites .
8
176,268
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25465830
1conclusions
Management of patients with ADHF varies significantly , and after adjustment , CCU care was associated with higher risk of early mortality , not explained by international differences .
9
176,269
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25465830
1conclusions
These findings may help to improve the early decisions regarding risk stratification of patients hospitalized with ADHF .
10
176,270
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26124485
3objective
Hand-foot syndrome ( HFS ) is a frequently occurring adverse event associated with anticancer drugs .
0
176,271
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26124485
3objective
This study compares a newly introduced ointment containing several antioxidants and exhibiting high radical protection factor , which has been available on the German market since @ , with urea cream for prevention of HFS in patients treated with capecitabine .
1
176,272
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26124485
2methods
Patients with GI tumors or breast cancer treated with capecitabine were included in this randomized phase III study .
2
176,273
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26124485
2methods
The primary end point was prevention of HFS of any grade within @ weeks of treatment as indicated by a standardized patient diary .
3
176,274
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26124485
2methods
The study had @ % power to show a @ % reduction of the incidence of HFS with the new ointment .
4
176,275
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26124485
2methods
Secondary end points included time to development of HFS greater than grade @ , evaluation of capecitabine dose intensity , and quality of life analyses .
5
176,276
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26124485
4results
A total of @ patients were evaluable .
6
176,277
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26124485
4results
In total , @ of @ patients experienced HFS ( @ % ) , @ % with the new ointment and @ % in the urea arm ( stratified odds ratio , @ ; P = @ ) .
7
176,278
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26124485
4results
Time to HFS greater than grade @ was comparable , but time to any-grade HFS was significantly longer in the urea group ( P = @ ) .
8
176,279
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26124485
4results
Capecitabine dose intensity , time under study , and percentage of days with correct administration of study medication were identical , as were adverse events except for HFS .
9
176,280
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26124485
4results
Skin-related quality of life was significantly worse in the group treated with the new ointment at the end of study treatment .
10
176,281
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26124485
1conclusions
This trial demonstrated that @ % urea cream was superior to the new ointment at preventing HFS over the first @ weeks of treatment with capecitabine .
11
176,282
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25225241
0background
Atrial fibrillation ( AFib ) is common in heart failure ( HF ) with preserved ejection fraction ( HFpEF ) .
0
176,283
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25225241
0background
Current AFib stroke risk prediction models include the presence of HF but do not specifically include HFpEF as a risk factor .
1
176,284
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25225241
0background
Whether a history of AFib should be used to identify patients with HFpEF who are at risk has not been established .
2
176,285
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25225241
4results
Baseline characteristics and outcomes of patients with HFpEF in the Irbesartan in Heart Failure with Preserved Ejection Fraction Trial were analyzed in relation to AFib .
3
176,286
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25225241
4results
At baseline , @ ( @ % ) had a history of AFib .
4
176,287
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25225241
4results
Of these @ ( @ % ) had history of AFib alone , whereas @ ( @ % ) had both a history and AFib on ECG ; @ ( @ % ) had neither .
5
176,288
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25225241
4results
There were no significant differences in the risk of stroke between the @ groups with a history of AFib who did or did not have AFib present on baseline ECG .
6
176,289
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25225241
4results
During a median follow-up of @ months , a fatal or nonfatal stroke occurred in @ % ( @/@ ) patients with history of AFib compared with @ % ( @/@ ) with no AFib .
7
176,290
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25225241
4results
Having a history of AFib was independently associated with higher risk of stroke ( hazard ratio , @ ; @ % confidence interval , @-@ @ ; P < @ ) compared with those with no history of AFib .
8
176,291
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25225241
1conclusions
In patients with HFpEF , a history of AFib was common and independently associated with increased risk of stroke , regardless of whether AFib was present on ECG .
9
176,292
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25225241
1conclusions
Patients with HFpEF and a history of AFib should be considered at risk .
10
176,293
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25225241
1conclusions
Further studies are needed to determine whether this risk can be safely reduced .
11
176,294
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25637376
0background
Selective kappa opioid receptor antagonism is a promising experimental strategy for the treatment of depression .
0
176,295
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25637376
0background
The kappa opioid receptor antagonist , LY@ , exhibits ~ @-fold higher affinity for kappa opioid receptors over mu opioid receptors , which is the next closest identified pharmacology .
1
176,296
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25637376
2methods
Here , we determined kappa opioid receptor pharmacological selectivity of LY@ by assessing mu opioid receptor antagonism using translational pupillometry in rats and humans .
2
176,297
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25637376
4results
In rats , morphine-induced mydriasis was completely blocked by the nonselective opioid receptor antagonist naloxone ( @mg/kg , which produced @ % mu opioid receptor occupancy ) , while @ and @ mg/kg LY@ ( which produced @ % and @ % mu opioid receptor occupancy , respectively ) only partially blocked morphine-induced mydriasis .
3
176,298
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25637376
4results
In humans , fentanyl-induced miosis was completely blocked by @mg naltrexone , and LY@ dose-dependently blocked miosis at @ and @ mg ( minimal-to-no blockade at @-@mg ) .
4
176,299
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