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embedding_all-mpnet-base-v2
sequence
embedding_multi-qa-mpnet-base-dot-v1
sequence
embedding_all-MiniLM-L12-v2
sequence
25637376
1conclusions
We demonstrate , for the first time , the use of translational pupillometry in the context of receptor occupancy to identify a clinical dose of LY@ achieving maximal kappa opioid receptor occupancy without evidence of significant mu receptor antagonism .
5
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24992750
3objective
To compare the efficacy of an acupuncture regimen for persistent allergic rhinitis ( PER ) , aimed at improving a patient 's mind or Shen in Traditional Chinese Medicine , to that of a second-generation Hi-receptor antagonist , cetirizine hydrochloride .
0
176,301
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24992750
2methods
This multicenter , randomized , controlled clinical trial on PER will be conducted at three institutions in China .
1
176,302
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24992750
2methods
The total study period will be @ weeks .
2
176,303
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24992750
2methods
After a @-week preparatory screening period , @ eligible participants with PER will be randomized to receive acupuncture or pharmacotherapy ( @:@ ) for @ weeks with a @-week follow-up .
3
176,304
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24992750
2methods
The primary outcome will be changes in @-day average total nasal symptom score .
4
176,305
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24992750
2methods
Secondary outcome measures include rhinoconjunctivitis quality of life questionnaire score and total non-nasal symptom score .
5
176,306
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24992750
4results
The presence and seriousness of psychological and emotional impairments should be considered in therapeutic programs for allergic rhinitis .
6
176,307
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24992750
4results
No clinical trial for treating allergic rhinitis via acupuncture regulation of psychological and emotional activities has been reported .
7
176,308
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24992750
1conclusions
The findings of the trial will allow us to determine the effects of the mind ( Shen ) - regulation treatment approach .
8
176,309
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24992750
1conclusions
We will also be able to confirm if the effects of acupuncture are equivalent to those of the conventional drug cetirizine hydrochloride .
9
176,310
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25516315
0background
Probiotics are microbial supplements that have shown efficacy in a wide range of applications .
0
176,311
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25516315
0background
To assess the safety and effects of enteral probiotics in critically ill neonates .
1
176,312
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25516315
2methods
A double-blind , randomized controlled trial was conducted in @ full-term infants with critical illness according to scores of neonatal acute physiology .
2
176,313
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25516315
2methods
Fifty neonatal intensive care patients were randomly assigned to receive probiotics three times daily after birth for @ days , and fifty patients were not given probiotics , but who received a placebo .
3
176,314
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25516315
2methods
The incidence of sepsis , multiple organ dysfunction syndrome ( MODS ) , nosocomial pneumonia , and necrotizing enterocolitis were recorded .
4
176,315
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25516315
2methods
The prognosis of probiotic treatment was determined based on the rate of recovery and hospital days .
5
176,316
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25516315
2methods
Serum IgA , IgG , and IgM concentrations were measured on days @ and @ .
6
176,317
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25516315
4results
Infants in the probiotics group showed a significantly reduced rate of nosocomial pneumonia ( @ % versus @ % ) and multiple organ dysfunction syndrome ( @ % versus @ % ) compared with the placebo group ( p < @ ) .
7
176,318
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25516315
4results
Significant results were demonstrated in favour of the probiotics for days of hospital stay ( @ @ d versus @ @ d ) ( p < @ ) .
8
176,319
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25516315
4results
However , there were no significant differences in the occurrence of sepsis , necrotizing enterocolitis , and recovery rate .
9
176,320
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25516315
4results
Patients given probiotics had significantly greater levels of IgA than those in the placebo group ( p < @ ) .
10
176,321
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25516315
4results
No serious adverse effects in the study population were noted .
11
176,322
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25516315
1conclusions
Supplements of probiotics to critically ill neonates could enhance immune activity , decrease occurrence of nosocomial pneumonia and MODS , and reduce days in hospital .
12
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24275612
0background
Recently , there have been investigations that have targeted improving the relatively poor validity and reliability of attentional bias measures .
0
176,324
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24275612
0background
These studies have demonstrated that individuals show elevated attentional bias to stimuli associated with their drinking history , although to date , the predictive utility of these measures has yet to be assessed .
1
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24275612
0background
The current study aimed to investigate the predictive value of an individualised alcohol Stroop task compared to that of an alcohol Stroop task with general alcohol-related words in a sample of non-dependent undergraduate drinkers .
2
176,326
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24275612
2methods
@ undergraduate social drinkers completed questionnaire measures of alcohol consumption and hazardous drinking which were combined to get an alcohol involvement measure .
3
176,327
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24275612
2methods
Participants also completed three blocked format Stroop tasks , a control Stroop ( containing soft drink-related words ) , a general alcohol Stroop ( containing a mixture of alcohol-related words ) and an individualised Stroop that contained words relating to the participants ' favourite alcoholic drink .
4
176,328
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24275612
4results
Although there was no significant difference in participants ' performance across the three different Stroop tasks , only performance on the individualised Stroop was associated with alcohol involvement .
5
176,329
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24275612
4results
Notably , the individualised Stroop predicted variance in drinking after controlling for demographics and general alcohol Stroop performance .
6
176,330
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24275612
1conclusions
This study indicates that adopting individualised stimuli into attentional bias tasks may increase their predictive validity .
7
176,331
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25440796
0background
Following acute coronary syndrome ( ACS ) , the risk for future cardiovascular events is high and is related to levels of low-density lipoprotein cholesterol ( LDL-C ) even within the setting of intensive statin treatment .
0
176,332
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25440796
0background
Proprotein convertase subtilisin/kexin type @ ( PCSK@ ) regulates LDL receptor expression and circulating levels of LDL-C .
1
176,333
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25440796
0background
Antibodies to PCSK@ can produce substantial and sustained reductions of LDL-C .
2
176,334
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25440796
0background
The ODYSSEY Outcomes trial tests the hypothesis that treatment with alirocumab , a fully human monoclonal antibody to PCSK@ , improves cardiovascular outcomes after ACS .
3
176,335
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25440796
2methods
This Phase @ study will randomize approximately @,@ patients to receive biweekly injections of alirocumab ( @-@ mg ) or matching placebo beginning @ to @ months after an index hospitalization for acute myocardial infarction or unstable angina .
4
176,336
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25440796
2methods
Qualifying patients are treated with atorvastatin @ or @ mg daily , rosuvastatin @ or @ mg daily , or the maximum tolerated and approved dose of one of these agents and fulfill one of the following criteria : LDL-C @ mg/dL , non-high-density lipoprotein cholesterol @ mg/dL , or apolipoprotein B @ mg/dL .
5
176,337
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25440796
2methods
The primary efficacy measure is time to first occurrence of coronary heart disease death , acute myocardial infarction , hospitalization for unstable angina , or ischemic stroke .
6
176,338
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25440796
2methods
The trial is expected to continue until @ primary end point events have occurred with minimum follow-up of at least @ years , providing @ % power to detect a @ % hazard reduction .
7
176,339
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25440796
2methods
Adverse events of special interest include allergic events and injection site reactions .
8
176,340
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25440796
2methods
Interim analyses are planned when approximately @ % and @ % of the targeted number of primary end points have occurred .
9
176,341
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25440796
1conclusions
ODYSSEY Outcomes will determine whether the addition of the PCSK@ antibody alirocumab to intensive statin therapy reduces cardiovascular morbidity and mortality after ACS .
10
176,342
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25926413
0background
Intrauterine growth restriction may be reduced by supplementing maternal diets during pregnancy , but few studies have assessed the impact of combined prenatal and postnatal interventions on child growth .
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176,343
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25926413
3objective
We tested a hypothesis that provision of small-quantity lipid-based nutrient supplements ( SQ-LNSs ) to mothers in pregnancy and @ mo postpartum and to their infants from @ to @ mo of age would promote infant and child growth in the study area in rural Malawi .
1
176,344
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25926413
2methods
We enrolled @ pregnant women in a randomized trial in Malawi .
2
176,345
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25926413
2methods
During pregnancy and @ mo thereafter , the women received daily @ capsule of iron-folic acid ( IFA ) , @ capsule containing @ micronutrients ( MMN ) , or one @-g sachet of SQ-LNS -LSB- lipid-based nutrient supplements ( LNS ) , containing @ MMN , protein , carbohydrates , essential fatty acids , and @ kcal -RSB- .
3
176,346
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25926413
2methods
Children in the IFA and MMN groups received no supplementation ; children in the LNS group received SQ-LNSs from @ to @ mo. .
4
176,347
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25926413
2methods
Primary outcome was child length at @ mo. .
5
176,348
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25926413
4results
At @ mo , the mean length in the IFA , MMN , and LNS groups was @ , @ , and @ cm ( P = @ ) , respectively , and the prevalence of stunting was @ % , @ % , and @ % ( P = @ ) , respectively .
6
176,349
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25926413
4results
No intergroup differences were found in the mean weight , head circumference , or midupper arm circumference or the proportions with low z scores for these variables ( P > @ ) .
7
176,350
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25926413
4results
Covariate adjustment did not change the analysis results , and the associations between the intervention and child length were not modified by maternal parity , age , or nutritional status ( P > @ ) .
8
176,351
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25926413
1conclusions
The findings do not support a hypothesis that provision of SQ-LNSs to women in pregnancy and postpartum and to children from @ to @ mo of age would promote child growth in this Malawian study area .
9
176,352
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25926413
1conclusions
This trial was registered at clinicaltrials.gov as NCT@ .
10
176,353
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25265770
0background
Femoral nerve block ( FNB ) with varying concentrations of bupivacaine is often used for postoperative analgesia after anterior cruciate ligament ( ACL ) reconstruction .
0
176,354
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25265770
3objective
To determine whether FNB using @ % or @ % bupivacaine provided better analgesia with less effect on quadriceps strengths after ACL reconstruction .
1
176,355
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25265770
2methods
One hundred patients were randomized to receive FNB with @ mL of @ % or @ % bupivacaine .
2
176,356
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25265770
2methods
Data regarding demographic , effectiveness of FNB , time to first pain , time to first analgesic , pain scores , morphine use , and recovery of sensory and motor function were recorded .
3
176,357
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25265770
4results
Median time to first morphine requirement was @ hours in @ % bupivacaine group and @ hours in @ % bupivacaine group ( p = @ ) .
4
176,358
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25265770
4results
Pain score at @ hours was lower in @ % bupivacaine group compared with @ % bupivacaine group ( p = @ ) .
5
176,359
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25265770
4results
When specify to the patellar tendon graft subgroup , the patients requiring morphine were @ % in @ % bupivacaine group and @ % in @ % bupivacaine group ( p = @ ) .
6
176,360
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25265770
4results
No differences were found in demographic data , effectiveness of FNB , time to first pain , morphine consumption , and recovery of sensorimotor function .
7
176,361
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25265770
1conclusions
FNB with @ % bupivacaine provided longer time to first analgesic and lower narcotic requirements after patellar tendon graft ACL reconstruction when compared to @ % bupivacaine .
8
176,362
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25265770
1conclusions
Both concentrations showed similar effect on quadriceps strengths .
9
176,363
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25908281
3objective
To establish a preoperative deep venous thrombosis predictor score for patients with fresh lower extremity fractures by statistical analysis .
0
176,364
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25908281
2methods
From January @ to December @ , @ @ patients with fresh lower extremity fractures were admitted to department of orthopaedic trauma , Beijing Jishuitan Hospital .
1
176,365
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25908281
2methods
They were randomly divided into two groups , the group @ ( n = @ ) was used to screen risk factors and derived a predictive models based on logistic regression , the group @ ( n = @ ) validated the models .
2
176,366
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25908281
4results
Among the patients , there were @ @ male and @ female patients , with an average age of ( @ @ ) years.Variables related to preoperative deep venous thrombosis were age , length of time before surgery , cause of injury , low/high-energy injury , location of injury , history of cardiovascular and cerebrovascular diseases , and D-Dimer .
3
176,367
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25908281
4results
The scores based on OR were : age @ years : @ point , > @ - < @ years : @ points , @ years : @ points ; length of time before surgery , < @ days :@ point , @ days :@ points ; low-energy injury :@ point , high energy injury :@ points ; location of injury , foot and ankle :@ point , calf :@ points , around the knee : @ points , femoral diaphysis and proximal femur :@ points , pelvis and acetabulum :@ points , @ sites :@ point ; history of cardiovascular and cerebrovascular diseases , yes :@ points , no :@ point .
4
176,368
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25908281
4results
D-Dimer < @ g/L :@ point , @ g/L :@ points .
5
176,369
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25908281
4results
Area under receiver operating characteristic curve was @ , critical point @ points , sensitivity was @ % , specificity was @ % .
6
176,370
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25908281
1conclusions
The score can predict the preoperative deep venous thrombosis for patients with fresh lower extremity fractures , but limited .
7
176,371
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24342265
3objective
To investigate if baseline depression moderated response to Media Smart , an @-lesson school-based program previously found to achieve a long-term risk reduction effect in young adolescents .
0
176,372
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24342265
2methods
@ Grade @ students ( M age = @ years , SD = @ ) from @ schools participated with @ classes receiving the Media Smart program ( @ girls ; @ boys ) and @ comparison classes receiving their normal lessons ( @ girls ; @ boys ) .
1
176,373
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24342265
2methods
Shape and weight concern , media internalization , body dissatisfaction , dieting , ineffectiveness , and perceived pressure were the outcome variables .
2
176,374
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24342265
4results
Moderation was indicated by significant interaction effects for group ( Media Smart ; Control ) moderator ( high depression ; low depression ) time ( post-program ; @-month follow-up ; @-year follow-up ) , with baseline entered as a covariate .
3
176,375
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24342265
4results
Such effects were found for shape and weight concern , media internalization , body dissatisfaction , ineffectiveness and perceived pressure .
4
176,376
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24342265
4results
Post-hoc testing found high depression Media Smart participants scored significantly lower than their control counterparts at post-program on shape and weight concern , media internalization and dieting , whereas low depression Media Smart participants scored significantly lower on shape and weight concern at @-year follow-up .
5
176,377
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24342265
1conclusions
Media Smart achieved a reduction in eating disorder risk factors for high-depression participants and a reduced rate of growth in risk factor scores for low-depression participants .
6
176,378
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24342265
1conclusions
Trial registry name : Australian New Zealand Clinical Trials Registry .
7
176,379
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24342265
1conclusions
URL : http://www.anzctr.org.au .
8
176,380
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24342265
1conclusions
Registration identification number : ACTRN@ .
9
176,381
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24824900
3objective
The purpose of this study was to determine the effects of early outpatient exercise on muscle mass , function , and fractional synthetic rate in severely burned children .
0
176,382
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24824900
2methods
Forty-seven children with @ % total body surface area burn performed a @-wk standard of care rehabilitation ( SOC , n = @ ) or rehabilitative exercise training ( RET , n = @ ) immediately after hospital discharge .
1
176,383
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24824900
2methods
Dual-energy x-ray absorptiometry was used to assess lean body mass ( LBM ) at discharge , posttreatment , and @ months post-burn .
2
176,384
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24824900
2methods
Muscle function was evaluated with a Biodex Isokinetic Dynamometer , and peak aerobic fitness ( VO@peak ) was measured using a modified Bruce treadmill protocol posttreatment .
3
176,385
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24824900
2methods
Stable isotope infusion studies were performed in a subset of patients ( SOC , n = @ ; RET , n = @ ) at discharge and posttreatment to determine mixed-muscle fractional synthetic rate .
4
176,386
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24824900
4results
Relative peak torque ( RET , @ @ Nmkg , vs SOC , @ @ Nmkg ) and VO@peak ( RET , @ @ mLkgmin , vs SOC , @ @ mLkgmin ) were greater at posttreatment with RET compared with those with SOC .
5
176,387
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24824900
4results
In addition , RET increased whole-body ( @ % @ % ) and leg ( @ % @ % ) LBM compared with SOC .
6
176,388
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24824900
4results
Furthermore , the percentage change in whole-body ( @ % @ % ) and leg ( @ % @ % ) LBM from discharge to @ months post-burn was greater with RET compared to SOC .
7
176,389
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24824900
4results
Muscle fractional synthetic rate decreased from discharge to posttreatment in both groups ( @ % @ % per day vs @ @ % per day ) ; however , no differences were observed between treatment groups at each time point .
8
176,390
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24824900
1conclusions
Early outpatient exercise training implemented at hospital discharge represents an effective intervention to improve muscle mass and function after severe burn injury .
9
176,391
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24425420
0background
This study compared generalized complex fractionated atrial electrograms ( CFAE ) ablation versus a selective CFAE ablation strategy targeting areas of continuous electric activity .
0
176,392
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24425420
4results
Subjects with symptomatic , persistent/high-burden paroxysmal atrial fibrillation ( AF ) were enrolled at @ centers ( n = @ ) and randomized to @ of @ arms .
1
176,393
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24425420
4results
For group I , all CFAE regions with an interval confidence level > @ were ablated followed by pulmonary vein isolation ( PVI ) .
2
176,394
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24425420
4results
For group II , only CFAE sites with continuous electric activity were ablated followed by PVI .
3
176,395
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24425420
4results
For PVI , all @ PV antra were isolated with confirmed entrance block .
4
176,396
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24425420
4results
Subjects were followed for @ year with a visit , ECG , and @-hour Holter every @ months .
5
176,397
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24425420
4results
Symptoms were confirmed by loop recording .
6
176,398
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24425420
4results
The primary end point was freedom from arrhythmia > @ seconds at @ year .
7
176,399
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