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embedding_all-mpnet-base-v2
sequence
embedding_multi-qa-mpnet-base-dot-v1
sequence
embedding_all-MiniLM-L12-v2
sequence
24425420
4results
For both group I and II , CFAE ablation prolonged AF cycle length ( @ versus @ ms ; P = @ ) and resulted in similar rates of AF termination ( @ % versus @ % ; P = @ ) .
8
176,400
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24425420
4results
Radiofrequency duration during CFAE ablation was significantly less in group II ( @ versus @ minutes ; P = @ ) .
9
176,401
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24425420
4results
At @-year follow-up , freedom from AF/atrial flutter/atrial tachycardia recurrence was significantly higher in group I versus group II after @ procedure ( @ % versus @ % ; P = @ ) .
10
176,402
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24425420
4results
There were also significantly fewer repeat procedures in group I ( @ % versus @ % ; P = @ ) .
11
176,403
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24425420
1conclusions
Continuous electric activity ablation + PVI result in a similar incidence of acute AF termination with significantly less radiofrequency time .
12
176,404
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24425420
1conclusions
However , incidence of repeat procedures and long-term recurrence of AF/atrial flutter/atrial tachycardia are significantly lower using generalized CFAE ablation + PVI .
13
176,405
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24425420
1conclusions
Clinical Trial Registration - URL : http://www.clinicaltrials.gov .
14
176,406
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24425420
1conclusions
Unique identifier : NCT@ .
15
176,407
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24262684
3objective
To determine if the use of a Bakri balloon at cesarean delivery ( CD ) for placenta previa is associated with a reduced need for additional surgical or pharmacologic measures and less blood loss than usual practices .
0
176,408
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24262684
2methods
In a randomized controlled trial , @ women undergoing CD for placenta previa were randomly allocated @:@ into an intervention arm ( prophylactic Bakri balloon immediately following placental delivery ) or a control arm ( use of any usual surgical/pharmacologic measures to achieve hemostasis ) .
1
176,409
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24262684
2methods
The primary outcomes were a clinician 's decision to undertake further intervention to control bleeding , and the difference between preoperative and postoperative hemoglobin levels .
2
176,410
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24262684
4results
Although fewer women in the intervention group required additional measures to achieve hemostasis during CD , the difference between the groups was not significant ( relative risk @ ; @ % confidence interval , @-@ @ ) .
3
176,411
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24262684
4results
The change in hemoglobin level among women in the intervention arm was also similar to that among controls ( @ g/dL ; @ % confidence interval , -@ to @ ) .
4
176,412
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24262684
1conclusions
The prophylactic use of a Bakri balloon at CD for placenta previa tended to be of benefit , with no evidence of harm or patient dissatisfaction , but the need for additional medical/surgical measures to control blood loss was not significantly reduced .
5
176,413
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24262684
1conclusions
Australian New Zealand Clinical Trials Registry : ACTRN@ .
6
176,414
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24439980
0background
Exercise training is recommended for chronic heart failure ( HF ) patients to improve functional status and reduce risk of adverse outcomes .
0
176,415
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24439980
0background
Elevated plasma levels of amino-terminal pro-brain natriuretic peptide ( NT-proBNP ) , high-sensitivity C-reactive protein ( hs-CRP ) , and cardiac troponin T ( cTnT ) are associated with increased risk of adverse outcomes in this patient population .
1
176,416
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24439980
0background
Whether exercise training leads to improvements in biomarkers and how such improvements relate to clinical outcomes are unclear .
2
176,417
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24439980
4results
Amino-terminal pro-brain natriuretic peptide , hs-CRP , and cTnT levels were assessed at baseline and @ months in a cohort of @ subjects from the HF-ACTION study , a randomized clinical trial of exercise training versus usual care in chronic HF patients with reduced left ventricular ejection fraction ( < @ % ) .
3
176,418
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24439980
4results
Linear and logistic regressions were used to assess @-month biomarker levels as a function of baseline value , treatment assignment ( exercise training vs usual care ) , and volume of exercise .
4
176,419
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24439980
4results
Linear regression and Cox proportional hazard modeling were used to evaluate the relations between changes in biomarker levels and clinical outcomes of interest that included change in peak oxygen consumption ( peak VO@ ) , hospitalizations , and mortality .
5
176,420
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24439980
4results
Exercise training was not associated with significant changes in levels of NT-proBNP ( P = @ ) , hs-CRP ( P = @ ) , or detectable cTnT levels ( P = @ ) at @ months .
6
176,421
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24439980
4results
Controlling for baseline biomarker levels or volume of exercise did not alter these findings .
7
176,422
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24439980
4results
Decreases in plasma concentrations of NT-proBNP , but not hs-CRP or cTnT , were associated with increases in peak VO@ ( P < @ ) at @ months and decreased risk of hospitalizations or mortality ( P @ ) , even after adjustment for a comprehensive set of known predictors .
8
176,423
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24439980
1conclusions
Exercise training did not lead to meaningful changes in biomarkers of myocardial stress , inflammation , or necrosis in patients with chronic HF .
9
176,424
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24439980
1conclusions
Only improvements in NT-proBNP translated to reductions in peak VO@ and reduced risk of clinical events .
10
176,425
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25411289
0background
Biofortification is a strategy to relieve vitamin A ( VA ) deficiency .
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176,426
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25411289
0background
Biofortified maize contains enhanced provitamin A concentrations and has been bioefficacious in animal and small human studies .
1
176,427
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25411289
3objective
The study sought to determine changes in total body reserves ( TBRs ) of vitamin A with consumption of biofortified maize .
2
176,428
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25411289
2methods
A randomized , placebo-controlled biofortified maize efficacy trial was conducted in @ rural Zambian children .
3
176,429
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25411289
2methods
The paired ( @ ) C-retinol isotope dilution test , a sensitive biomarker for VA status , was used to measure TBRs before and after a @-d intervention .
4
176,430
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25411289
2methods
Treatments were white maize with placebo oil ( VA - ) , orange maize with placebo ( orange ) , and white maize with VA in oil -LSB- @ g retinol activity equivalents ( RAEs ) in @ L daily -RSB- ( VA + ) .
5
176,431
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25411289
4results
In total , @ children completed the trial and were analyzed for TBRs ( n = @ or @/group ) .
6
176,432
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25411289
4results
Change in TBR residuals were not normally distributed ( P < @ ) ; median changes ( @ % CI ) were as follows : VA - , @ ( -@ , @ ) mol ; orange , @ ( @ , @ ) mol ; and VA + , @ ( @ , @ ) mol .
7
176,433
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25411289
4results
Nonparametric analysis showed no statistical difference between VA + and orange ( P = @ ) ; both were higher than VA - ( P = @ ) .
8
176,434
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25411289
4results
Median ( @ % CI ) calculated liver reserves at baseline were @ ( @ , @ ) mol/g liver , with @ % > @ mol/g , the subtoxicity cutoff ; none were < @ mol/g , the deficiency cutoff .
9
176,435
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25411289
4results
The calculated bioconversion factor was @ g - carotene equivalents/@ g retinol by using the middle @ quintiles of change in TBRs from each group .
10
176,436
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25411289
4results
Serum retinol did not change in response to intervention ( P = @ ) but was reduced with elevated C-reactive protein ( P = @ ) and -@ - acid glycoprotein ( P = @ ) at baseline .
11
176,437
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25411289
1conclusions
- Carotene from maize was efficacious when consumed as a staple food in this population and could avoid the potential for hypervitaminosis A that was observed with the use of preformed VA from supplementation and fortification .
12
176,438
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25411289
1conclusions
Use of more sensitive methods other than serum retinol alone , such as isotope dilution , is required to accurately assess VA status , evaluate interventions , and investigate the interaction of VA status and infection .
13
176,439
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25411289
1conclusions
This trial was registered at clinicaltrials.gov as NCT@ .
14
176,440
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24224521
0background
Submassive pulmonary embolism ( PE ) has a low mortality rate but can degrade functional capacity .
0
176,441
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24224521
3objective
The present study aims to provide rationale , methodology , and initial findings of a multicentre , randomised trial of fibrinolysis for PE that used a composite end-point , including quality of life measures .
1
176,442
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24224521
2methods
This investigator-initiated study was funded by a contract between a corporate partner and the investigator 's hospital ( the prime site ) .
2
176,443
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24224521
2methods
The investigator was the Food and Drug Administration ( FDA ) sponsor .
3
176,444
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24224521
2methods
The prime site subcontracted , indemnified , and trained consortia members .
4
176,445
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24224521
2methods
Consenting , normotensive patients with PE and right ventricular strain ( by echocardiography or biomarkers ) received low-molecular-weight heparin and random assignment to a single bolus of tenecteplase or placebo in double-blinded fashion .
5
176,446
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24224521
2methods
The outcomes were : ( i ) in-hospital rate of intubation , vasopressor support , and major haemorrhage , or ( ii ) at @ days , death , recurrent PE , or composite that defined poor quality of life ( echocardiography , @ min walk test and surveys ) .
6
176,447
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24224521
2methods
The planned sample size was n = @ .
7
176,448
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24224521
4results
Eight sites enrolled @ patients over @ years .
8
176,449
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24224521
4results
The ratio of patients screened for each enrolled was @ to @ , equating to @ h screening time per patient enrolled .
9
176,450
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24224521
4results
Primary barrier to enrolment was the cost of screening .
10
176,451
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24224521
4results
Two patients died ( @ % , @ % CI -LSB- @-@ % -RSB- ) , one developed shock , but @ ( @ % , @ % CI : -LSB- @-@ % -RSB- ) had a poor quality of life .
11
176,452
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24224521
1conclusions
An investigator-initiated , FDA-regulated , multicentre trial of fibrinolysis for submassive PE was conducted , but was limited by screening costs and a low mortality rate .
12
176,453
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24224521
1conclusions
Quality of life measurements might represent a more important patient-centred end-point .
13
176,454
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25082132
0background
Crashes are the leading cause of death for teens , and parent-based interventions are a promising approach .
0
176,455
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25082132
0background
We assess the effectiveness of Steering Teens Safe , a parent-focused program to increase safe teen driving .
1
176,456
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25082132
2methods
Steering Teens Safe aimed to improve parental communication with teens about safe driving using motivational interviewing techniques in conjunction with @ safe driving lessons .
2
176,457
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25082132
2methods
A randomized controlled trial involved @ parent-teen dyads ( @ intervention and @ control ) .
3
176,458
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25082132
2methods
Intervention parents received a @-minute session to learn the program with four follow-up phone sessions , a DVD , and a workbook .
4
176,459
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25082132
2methods
Control parents received a standard brochure about safe driving .
5
176,460
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25082132
2methods
Scores were developed to measure teen-reported quantity and quality of parental communication about safe driving .
6
176,461
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25082132
2methods
The main outcome measure was a previously validated Risky Driving Score reported by teens .
7
176,462
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25082132
2methods
Because the Score was highly skewed , a generalized linear model based on a gamma distribution was used for analysis .
8
176,463
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25082132
4results
Intervention teens ranked their parent 's success in talking about driving safety higher than control teens ( p = @ ) and reported that their parents talked about more topics ( non-significant difference ) .
9
176,464
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25082132
4results
The Risky Driving Score was @ % lower in intervention compared to control teens ( @ % CI = @ , @ ) .
10
176,465
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25082132
4results
Interaction between communication quantity and the intervention was examined .
11
176,466
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25082132
4results
Intervention teens who reported more successful communication had a @ % lower Risky Driving Score ( @ % CI = @ , @ ) than control parents with less successful communication .
12
176,467
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25082132
1conclusions
This program had a positive although not strong effect , and it may hold the most promise in partnership with other programs , such as Driver 's Education or Graduated Driver 's License policies .
13
176,468
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24297946
3objective
Deep molecular response ( MR ( @ ) ) defines a subgroup of patients with chronic myeloid leukemia ( CML ) who may stay in unmaintained remission after treatment discontinuation .
0
176,469
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24297946
3objective
It is unclear how many patients achieve MR ( @ ) under different treatment modalities and whether MR ( @ ) predicts survival .
1
176,470
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24297946
2methods
Patients from the randomized CML-Study IV were analyzed for confirmed MR ( @ ) which was defined as @ log reduction of BCR-ABL on the international scale ( IS ) and determined by reverse transcriptase polymerase chain reaction in two consecutive analyses .
2
176,471
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24297946
2methods
Landmark analyses were performed to assess the impact of MR ( @ ) on survival .
3
176,472
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24297946
4results
Of @,@ randomly assigned patients , @,@ were assessable .
4
176,473
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24297946
4results
After a median observation time of @ months , @-year overall survival ( OS ) was @ % , @-year progression-free-survival was @ % , and @-year OS was @ % .
5
176,474
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24297946
4results
The cumulative incidence of MR ( @ ) after @ years was @ % ( median , @ years ) ; confirmed MR ( @ ) was @ % .
6
176,475
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24297946
4results
MR ( @ ) was reached more quickly with optimized high-dose imatinib than with imatinib @ mg/day ( P = @ ) .
7
176,476
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24297946
4results
Independent of treatment approach , confirmed MR ( @ ) at @ years predicted significantly higher survival probabilities than @ % to @ % IS , which corresponds to complete cytogenetic remission ( @-year OS , @ % v @ % ; P = @ ) .
8
176,477
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24297946
4results
High-dose imatinib and early major molecular remission predicted MR ( @ ) .
9
176,478
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24297946
4results
No patient with confirmed MR ( @ ) has experienced progression .
10
176,479
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24297946
1conclusions
MR ( @ ) is a new molecular predictor of long-term outcome , is reached by a majority of patients treated with imatinib , and is achieved more quickly with optimized high-dose imatinib , which may provide an improved therapeutic basis for treatment discontinuation in CML .
11
176,480
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25590323
3objective
To compare the efficacy and safety of endoscopic dacryocystorhinostomy ( En-DCR ) with different stent materials for lacrimal sac intubation in primary nasolacrimal ductal obstructions .
0
176,481
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25590323
2methods
Randomized controlled study with three parallel groups .
1
176,482
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25590323
2methods
Level of evidence is @b .
2
176,483
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25590323
2methods
A total of @ patients ( five bilateral ) with primary nasolacrimal duct obstruction ( NLDO ) at a tertiary referral center scheduled for En-DCR were to allocated into three stent groups with a sealed envelope and were randomized into three treatments : silicone , Prolene ( polypropylene ) , and otologic T-tube .
3
176,484
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25590323
2methods
Ophthalmology and otolaryngology clinics evaluated the patients preoperatively and postoperatively with endoscopes , lacrimal system syringing , and dacryocystography .
4
176,485
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25590323
2methods
The success of the stents was evaluated @ months after surgery with symptom relief and ostial patency .
5
176,486
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25590323
2methods
Complications were also noted .
6
176,487
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25590323
4results
The overall success rate of the En-DCR in the stent groups was @ % ( @/@ ) ; specifically , @ % ( @/@ ) with silicone , @ % ( @/@ ) with Prolene , and @ % ( @/@ ) with T-tube .
7
176,488
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25590323
4results
The efficacy of the procedures with the T-tube was significantly lower than that of the Prolene and silicone ( p = @ , ( @ ) test ) .
8
176,489
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25590323
4results
There were no significant differences between the silicone and Prolene ( p = @ , ( @ ) test ) .
9
176,490
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25590323
4results
Prolene was found to be related with orbital complications .
10
176,491
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25590323
4results
Spontaneous loss is a particular complication of otologic T-tube and highly portends to failure .
11
176,492
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25590323
1conclusions
The results of our study suggest that efficacy , defined as anatomic and functional success , is equally high for silicone and Prolene stents and lower for otologic T-tube in En-DCR .
12
176,493
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24751304
0background
Little is known about the longer-term effects of adjunctive benzodiazepines on symptom response during treatment in patients with bipolar disorders .
0
176,494
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24751304
2methods
The study sample consisted of @ patients with bipolar I or II disorder enrolled in a @-month , randomized , multi-site comparison of lithium - and quetiapine-based treatment .
1
176,495
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24751304
2methods
Changes in clinical measures ( BISS total and subscales , CGI-BP , and CGI-Efficacy Index ) were compared between participants who did and did not receive benzodiazepine treatment at baseline or during follow-up .
2
176,496
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24751304
2methods
Selected outcomes were also compared between patients who did and did not initiate benzodiazepines during follow-up using stabilized inverse probability weighted analyses .
3
176,497
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24751304
4results
Significant improvement in all outcome measures occurred within each benzodiazepine exposure group .
4
176,498
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24751304
4results
Benzodiazepine users ( at baseline or during follow-up ) experienced significantly less improvement in BISS total , BISS irritability , and CGI-BP scores than did benzodiazepine non-users .
5
176,499
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