sayyid14/MedMCQACancer · Datasets at Hugging Face

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0	All are true about Cancer breast, except:	Affected sibling is a risk factor	Paget's disease of nipple is intraductal type of CA	Common in aged nulliparous	Increased incidence with prolonged breast feeding	3
1	National program for prevention and control of Cancer, Diabetes, Cardiovascular disease and stroke (NPCDCS), true is -	Separate centre for stroke, DM, cancer	Implementation in some 5 states over 10 districts	District hospital has specialised facilities	Subcentre has facility for diagnosis and treatment	2
2	Hereditary non-polyposis colorectal cancer (HNPCC) has an increased risk of all the following except	Endometrium	Ovary	Stomach	Pancreas	3
3	All the following are the risk factors for cervical cancer except	Young age at first intercourse	Multiple sexual paners	Low parity	Low socioeconomic status	2
4	50 year old male with positive family history of prostate cancer has come to you for a screening test. The screening test done to pickup prostate cancer is	DRE	PSA	DRE + PSA	Endorectal coil MRI with T1 and T2 W images	2
5	A patient with cervix cancer is missed by a screening test and later diagnosed with advanced disease. This time interval is called ?	Lead time	Screening time	Serial interval	Generation time	0
6	Mrs Shikha, 50-years-old woman is diagnosed with cervical cancer. Which lymph node group would be the first involved in metastatic spread of this disease beyond the cervix and uterus? NOT RELATED -anatomy	Common iliac nodes	Parametrial nodes	External iliac node	Paracervical or ureteral nodes	3
7	Drug used in cancer chemotherapy induced vomiting is?	Aprepitant	Dexamethasone	Ondansetrin	All of the above	3
8	Anticoagulant of choice for prophylaxis of venous thromboembolism in patient with cancer surgery is:-	Heparin sulfate	Protamine sulfate	Low molecular weight heparin	Warfarin	2
9	Hypercalcemia is most commonly associated in which of the following cancers?	Renal cell cancer	Carcinoma stomach	Squamous cell carcinoma of lung	Hepatocellular carcinoma	2
10	A female undergone surgery for left breast cancer 3 yrs back now developed blue nodule on same side	Lymphangiosarcoma	Recurrence	Hemangioma	Cellulitis	0
11	16 yr unmarried girl came for vaccination against cervical cancer. Which vaccine to he given:	Gardasil	Rabivac	Biovac	Tvac	0
12	Which of the following anti–cancer drug is NOT 'S'–phase specific ?	Methotrexate	Mercaptopurine	Ifosfamide	Thioguanine	2
13	Krukenberg tumor is associated mostly with which cancer?	Stomach	Breast	Liver	Pancreas	0
14	Which cancer is most commonly associated with increased estrogen levels?	Cervix	Ovarian	Breast	GTN	2
15	The dose of radiation for point A for early and locally advancing cervical cancer during brachytherapy according to ABS guidelines is:	70-75Gy- 75-80Gy	75-75Gy- 80-85Gy	80-85Gy- 85-90Gy	85-90Gy- 90-95Gy	2
16	Most common radiation induced cancer:	Thyroid Carcinoma	Breast Carcinoma	Leukemia	Sarcomas	2
17	30 out of 50 smokers and 10 out of 50 non smokers develop lung cancer. What is odd's Ratio	4	2.8	6	7	2
18	A 70 year old male chronic smoker is diagnosed of having cancer of the urinary bladder. It is confined to the trigone and extention is upto the submucosa. The management would be -	Complete Transurethral resction	Complete Transurethral resection with intravesical chemotherapy	Palliative Radiotherapy	Radical Cystectomy	1
19	Ten days after an exploratory laparotomy and lysis of adhesions, a patient, who previously underwent a low anterior resection for rectal cancer followed by postoperative chemoradiation, is noted to have succus draining from the wound. She appears to have adequate source control--she is afebrile with a normal white blood count. The output from the fistula is approximately 150 cc per day. Which of the following factors is most likely to prevent closure of the enterocutaneous fistula?	Previous radiation	Previous chemotherapy	Recent surgery	History of malignancy	0
20	The first step when doing a pneumonectomy for cancer of the bronchus is to:	Ligate the pulmonary vein	Ligate pulmonary aery	Divide the bronchus	Perform lymph node clearance	1
21	Which of the following anticancer drug can cause flagellated dermatitis?	Cisplatin	L-asparginase	Doxorubicin	Bleomycin	3
22	In stage III ovarian cancer patient with upper abdominal disease < 5cm, management of choice is	Debulking surgery	Mantle cell irradiation	Abdomino-pelvic radiotherapy	Neo-adjuvant chemotherapy	0
23	The commonest cancer of oral cavity is	Adenocarcinoma	Melanoma	Sarcoma	Squaous cell carcinoma	3
24	Radiation induced thyroid cancer is -	Papillary	Follicular	Anaplastic	Medullary	0
25	The most common histologic type of thyroid cancer is -	Medullary type	Follicular type	Papillary type	Anaplastic type	2
26	Which type of Human papilloma virus is most commonly associated with Cervical cancer ?	HPV 16	HPV 24	HPV 32	HPV 36	0
27	Osteosclerotic metastasis is common in cancer of:	Prostate	Lungs	Malignant melanoma	Renal cell carcinoma	0
28	Hypercalcemia is seen in which cancer	RCC	Carcinoma stomach	Small cell carcinoma lung	Hepatocellular carcinoma	0
29	The following is not one of the 4 key cell cycle regulators which are dysregulated in a variety of human cancers	P16/INK4a	Cyclin D	P21	RB	2
30	About the treatment of esophageal cancer, false statement is:	5% of patients survive 5 years after the diagnosis	The efficacy of primary radiation therapy for squamous cell carcinomas is similar to that of radical surgery	Surgical resection of all gross tumor is feasible in only 45% of cases	Chemotherapy is highly effective and sometimes curable	3
31	Monoclonal antibody used in Head and neck cancer is:-	Pembrolizumab	Trastuzumab	Rituximab	Ocralizumab	0
32	The most common histologic type of thyroid cancer is	Medullary type	Follicular type	Papillary type	Anaplastic type	2
33	High-risk breast cancer female investigation of choice is?	MRI	USG	Mammography	Clinical examination	0
34	Gene associated with autosomal dominant breast cancer?	PTEN and KAI	BRCA 1 and 2	APC	P53	1
35	8000 rads dosage in Cancer cervix is given to -	Point A	Point B	Side walls of pelvis	None of the above	0
36	Anticancer drug also used in RA, produces acrolein in urine that leads to hemorrhagic cystitis	Cyclophosphamide	Busulfan	Procarbazine	Mesna	0
37	Precancerous lesion of gall bladder is	Porcelain gall bladder	Mirrizi syndrome	Cholesterosis	Acalculous Cholecystitis	0
38	In cancer colon investigation of choice is:	CT scan	Barium enema	Colonoscopy	X-ray	2
39	Use of oral contraceptives increases the risk of which cancer -	Colon	Ovary	Breast	All of the above	2
40	Which of the following is the most common cancer of thyroid	Anaplastic carcinoma	Follicular carcinoma	Papillary carcinoma	Medullary carcinoma	2
41	M/C ovarian cancer associated with endometriosis:	Endometroid tumor	Clear cell tumor	Germ cell tumor	Brenner tumor	1
42	Antifungal used as cancer chemotherapeutic agent is :	Flucytosine	Nystatin	Voriconazole	Terbinafine	0
43	True about tongue cancer:	Most common type is adenocarcinoma	Cervical lymph node metastasis is universally present	MC site is on Lateral margin	Slurring of speech is a common complaint	2
44	A 69 year old male presents with an episode of slurring of speech which lasted for 12 hours and then resolved.He is heavy smoker having smoked 60 cigarettes per day for 40 years. He had a single episode of haemoptysis 4 weeks previously and has underlying lung cancer with brain metastases and is referred for an urgent CT chest. An ECG was performed which showed new AF. All blood tests including cardiac biomarkers were normal. Chest CT is shown. Which of the following is most probable diagnosis?	Left atrial myxoma	Left atrial thrombus	Infective endocarditis	Rhabdomyoma	1
45	A pateint with cervix cancer is mised by a screeing test and later diagnosed with advanced disease. This time interval is called	Lead time	Screening time	Serial interval	Generation time	0
46	Which of the following anticancer drug can result in "disulfiram reaction"	Lomustine	L-Asparginase	Procarbazine	Busulfan	2
47	Several weeks after surgical dissection of her left axilla for the removal of lymph nodes for staging and treatment of her breast cancer, a 32-year-old woman was told by her general physician that she had "winging" of her left scapula when she pushed against resistance during her physical examination. She told the physician that she had also experienced difficulty lately in raising her right arm above her head when she was combing her hair. In a subsequent consult visit with her surgeon, she was told that a nerve was accidentally injured during the diagnostic surgical procedure and that this produced her scapular abnormality and inability to raise her arm normally. What was the origin of this nerve?	The upper trunk of her brachial plexus	The posterior division of the middle trunk	Roots of the brachial plexus	The posterior cord of the brachial plexus	2
48	In exocrine pancreatic cancer, the commonest tumour marker to be elevated as -	CA-125	CEA	CA-15-3	CA-19-9	3
49	Preferred method of contraception for a female with family H/O ovarian cancer :	POP	Cu IUCD	OCP	Barrier method	2
50	Which of the following is a precancerous condition of cancer stomach?	Peptic ulcer	Chronic gastric atrophy	Achalasia cardia	Curling's Ulcer	1
51	All of the following anticancer drugs are cell cycle non-specific except?	Cisplatin	Vincristine	Mitomycin-C	Cyclophosphamide	1
52	All of the following are hormonal agents used against breast cancer except -	Latrazole	Exemestane	Taxol	Tamoxifen	2
53	A 70-year-old man has smoked for years despite a chronic productive cough. One day, he notices blood in his sputum and goes to see his physician. A chest x-ray reveals a mass in the left lung, which is biopsied during a fiberoptic bronchoscopy. Assuming that this patient's cancer is etiologically related to his smoking, which of the following diagnoses are most likely to be returned by the pathology laboratory?	Adenocarcinoma or bronchioloalveolar carcinoma	Adenocarcinoma or small cell carcinoma	Bronchioloalveolar carcinoma or small cell carcinoma	Small cell carcinoma or squamous cell carcinoma	3
54	Which enzymatic mutation is responsible for immortality of cancer cells?	DNA reverse transcriptase	RNA polymerase	Telomerase	DNA polymerase	2
55	Strong correlation with colorectal cancer is seen in	Peutz-Jegher's polyp	Familial polyposis coli	Juvenile polyposis	Hyperplastic polyp	1
56	Which of the following is the investigation of choice for assessment of depth of penetration and perirectal node involvement in rectal cancer?	MRI scan	CT scan pelvis	Double contrast barium enema	Transrectal ultrasound	0
57	Patient because of positive biopsy findings and negative workup undergoes a radical prostatectomy. The pathology repo reveals Gleason score 9/10 and involvement of several pelvic lymph nodes. Which is the most likely site for prostatic cancer metastasis?	Liver	Kidney	Lung	Bone	3
58	The following anticancer drug has high emetogenic potential	Chlorambucil	Vincristine	6-Mercaptopurine	Cisplatin	3
59	The following condition of GB is precancerous -	Cholesterosis	Porcelain gall bladder	Biliary atresia	Choledochal cyst	1
60	Which of the following is a metastasis suppressor gene in relation to prostate cancer	KAI - 1	NM 23	KISS	p53	0
61	The following condition of GB is precancerous	Cholesterosis	Porcelain gall bladder	Biliary atresia	Choledochal cyst	1
62	Smoking is a risk factor for all cancer except:	Esophagus	Urinary bladder	Pancreas	Gallbladder	3
63	Which of the following anticancer drugs acts by hypomethylation?	Gemcitabine	5-FU	Decitabine	Homoharringotonine	2
64	First symptom in vulval cancer is-	Pain	Pruritus	Ulceration	Bloody discharge	1
65	A 58 year old male presents with hematuria. He s diagnosed of having bladder cancer which extends muscle deep. The best treatment is	Intravesical Chemotherapy	Neoadjuvant chemotherapy followed by radical cystectomy	Radiotherapy	Tranurethral resection	1
66	A 56-year-old woman with a history of breast cancer that was treated 5 years ago with lumpectomy and radiation but with no chemotherapy returns with bone pain, fatigue, and weakness. A complete blood count reveals severe anemia, as well as decreased white blood cells and platelets. Examination of a peripheral blood smear reveals small numbers of nucleated red cells, as well as an occasional "blast" cell and myelocyte. A likely cause of the hematologic abnormalities is	chloramphenicol.	Diphyllobothrium latum infestation.	megaloblastic anemia.	myelophthisic anemia.	3
67	All the following are hormonal agents used against breast cancer EXCEPT :	Letrozole	Exemestane	Taxol	Tamoxifen	2
68	Which group of anticancer drugs temozolomide belong to :	Oral alkylating agent	Antitumor Antibiotic	Antimetabolite	Mitotic Spindle Inhibitor	0
69	According to AJCC 8th edition, staging of 2 cm size pancreatic cancer if it involves poal vein in:	T1	T2	T3	T4	0
70	Nanotechnology has found tremendous application in the diagnosis of cancers because of all of following advantages, except	Nanocrystals exibit bright, photostable fluorescence	Nonocrystals have a narrow spectrum wavelength	Peak spectrum wavelength is tunable	Nanocrystals exhibit a narrow difference between their excitation and emission peak spectra	3
71	A 30 year old female presented with unilateral breast cancer associated with axillary lymph node enlargement. Modified radical mastectomy was done, fuher treatment plan will be:	Observation and follow up	Adriamycin based chemotherapy followed by tamoxifen depending on estrogen/progesterone receptor status	Adriamycin based chemotherapy only	Tamoxifen only	1
72	Most common histological subtype of cancer endometrium is :	Mucinous carcinoma	Clear cell carcinoma	Squamous cell carcinoma	Endometrioid adenocarcinoma	3
73	Most common lung cancers in non smokers is	Squamous cell carcinoma	Bronchoalveolar carcinoma	Small cell carcinoma	Adenocarcinoma	3
74	Which of the following is FALSE regarding breast cancer during pregnancy?	Axillary lymph node metastases in 75% of affected women	Mammography is sensitivity during pregnancy	Radiation cannot be considered for treatment	Less than 25% of the breast nodules are cancerous	1
75	A patient with oral cancer, had ipsilateral lymph node measuring 2 cm, single in number with capsular spread. According to TNM staging it is included under:	Nx	N1	N2	N3	3
76	Cell cycle specific anti-cancerous drug is?	Cyclophosphamide	Vincristine	Nitrogen mustard	Doxorubicin.	1
77	Commonest cancer in burn scar is -	Sq. cell Ca	Fibrosarcoma	Adenoa Ca	Adeno-squamous Ca	0
78	The postoperative quality of life (QOL) scores of 200 prostate cancer patients have a mean of 60 and a standard detion of 10. How many patients are expected to have a QOL score between 40 and 80?	190	136	120	140	0
79	Which one of the following is the most sensitive and specific screening test to detect breast cancer?	Regular X-ray	Self breast examination	Mammography	Regular biopsy	2
80	Origin of cancer cells in Krukenberg tumour is from: March 2013	Ovarian carcinoma	Gastric carcinoma	Duodenal carcinoma	Pancreatic carcinoma	1
81	Pseudomyxoma peritonii is seen in which ovarian cancer?	Serous cystadenocarcinoma	Mucinous cystadenocarcinoma	Brenner Tumor	Fibroma	1
82	EBV is associated with which type of cancer?	Nasopharyngeal carcinoma	Epidermodysplasia	Kaposi sarcoma	null	0
83	Cadmium can cause all cancer except-	Lung	Pancreas	Prostate	Skin	3
84	Most common type of HPV associated with cervical cancer ?	6, 11	5, 8	16, 18	6, 8	2
85	Which of the following pathologic findings is/are the strongest contraindication to breast preservation (lumpectomy with breast radiation) as primary treatment for a newly diagnosed breast cancer?	Grade 3, poorly differentiated, infiltrating ductal carcinoma	Extensive intraductal cancer around the invasive lesion	Tumor size less than 3 cm	Positive surgical margin for invasive cancer	3
86	If a 95% confidence interval for prevalence of cancer smokers aged> 65 years is 56% to 76%, the chance that the prevalence could be less than 56% is-	Nil	44%	2.50%	5%	2
87	Which of the following is a triple negative breast cancer -	Colloid Cancer	Secretory cell cancer	Acinic Cell Carcinoma	Mucinous Carcinoma	1
88	Example for radiation induced cancer is:	Papillary carcinoma thyroid	Follicular carcinoma thyroid	Lymphoma	Hepatoma	0
89	A 70-year-old woman with a history of ovarian cancer presents with diarrhea. She completed radiation therapy for her cancer 3 months ago. Physical examination shows cachexia, hyperactive bowel sounds, and generalized pallor. The stools are found to contain blood. A CBC shows decreased hemoglobin (7.8 g/dL) and decreased mean corpuscular volume (70 mm3). Which of the following is the most likely cause of GI bleeding in this patient?	Angiodysplasia	Hemorrhoids	Ischemic colitis	Radiation enterocolitis	3
90	Arrange the following causes of NCD deaths as per decreasing order of frequency? A. Cancers B. Cardiovascular diseases C. Diabetes D. Respiratory diseases	A>D>C>B	D>A>B>C	B>A>D>C	C>B>D>A	2
91	Virus causing cervical cancer in the ectocervix -	HPV16	HPV17	HPV11	HPV19	0
92	Which of the following strategy has been recommended to reduce the heredity risk for ovarian cancer in women with BRCA -1 and BRCA - 2 mutations :	Use of oral contraceptive pills	Screening with transvaginal ultrasound	Screening with CA - 125	Prophylactic oophorectomy	3
93	Precancerous lesion of bone among the following is	Paget disease	Chronic osteomyelitis	Benign giant cell tumor	All of the above	3
94	Cancer management in which of following malignancies has dramatically increased the survival?	Esophagus carcinoma	Glioblastoma multiforme	ALL in children	Cholangiocarcinoma	2
95	Example for radiation induced cancer is ?	Papillary carcinoma thyroid	Follicular carcinoma thyroid	Lymphoma	Hepatoma	0
96	Smoking predisposes to all of the following cancers except -	Carcinoma larynx	Carcinoma bladder	Carcinoma stomach	Lymphoma	3
97	A 70-year-old male Rohan with advanced visceral cancer dies of extensive myocardial infarction. Autopsy also reveals sterile non-destructive vegetations along the mitral leaflet edges. The pathogenesis of this patient's vegetations is most similar to that of:	Hypercalcemia of malignancy	Distant metastases	Trousseau syndrome	Raynaud's phenomenon	2
98	A patient with cancer developed extreme degree of radiation toxicity. Further history revealed that the dose adjustment of a particular drug was missed during the course of radiotherapy. Which of the following drugs required a dose adjustment during radiotherapy in order to prevent radiation toxicity?	Vincristine	Dactinomycin	Cyclophosphamide	6- Mercaptopurine	1
99	Anticancer drug causing nephrotoxicity: September 2009	Imitanib	Irinotecan	fosfestrol	Cisplatin	3

0

All are true about Cancer breast, except:

Affected sibling is a risk factor

Paget's disease of nipple is intraductal type of CA

Common in aged nulliparous

Increased incidence with prolonged breast feeding

3

1

National program for prevention and control of Cancer, Diabetes, Cardiovascular disease and stroke (NPCDCS), true is -

Separate centre for stroke, DM, cancer

Implementation in some 5 states over 10 districts

District hospital has specialised facilities

Subcentre has facility for diagnosis and treatment

2

Hereditary non-polyposis colorectal cancer (HNPCC) has an increased risk of all the following except

Endometrium

Ovary

Stomach

Pancreas

3

All the following are the risk factors for cervical cancer except

Young age at first intercourse

Multiple sexual paners

Low parity

Low socioeconomic status

2

4

50 year old male with positive family history of prostate cancer has come to you for a screening test. The screening test done to pickup prostate cancer is

DRE

PSA

DRE + PSA

Endorectal coil MRI with T1 and T2 W images

2

5

A patient with cervix cancer is missed by a screening test and later diagnosed with advanced disease. This time interval is called ?

Lead time

Screening time

Serial interval

Generation time

0

6

Mrs Shikha, 50-years-old woman is diagnosed with cervical cancer. Which lymph node group would be the first involved in metastatic spread of this disease beyond the cervix and uterus? NOT RELATED -anatomy

Common iliac nodes

Parametrial nodes

External iliac node

Paracervical or ureteral nodes

3

7

Drug used in cancer chemotherapy induced vomiting is?

Aprepitant

Dexamethasone

Ondansetrin

All of the above

3

8

Anticoagulant of choice for prophylaxis of venous thromboembolism in patient with cancer surgery is:-

Heparin sulfate

Protamine sulfate

Low molecular weight heparin

Warfarin

2

9

Hypercalcemia is most commonly associated in which of the following cancers?

Renal cell cancer

Carcinoma stomach

Squamous cell carcinoma of lung

Hepatocellular carcinoma

2

10

A female undergone surgery for left breast cancer 3 yrs back now developed blue nodule on same side

Lymphangiosarcoma

Recurrence

Hemangioma

Cellulitis

0

11

16 yr unmarried girl came for vaccination against cervical cancer. Which vaccine to he given:

Gardasil

Rabivac

Biovac

Tvac

0

12

Which of the following anti–cancer drug is NOT 'S'–phase specific ?

Methotrexate

Mercaptopurine

Ifosfamide

Thioguanine

2

13

Krukenberg tumor is associated mostly with which cancer?

Stomach

Breast

Liver

Pancreas

0

14

Which cancer is most commonly associated with increased estrogen levels?

Cervix

Ovarian

Breast

GTN

2

15

The dose of radiation for point A for early and locally advancing cervical cancer during brachytherapy according to ABS guidelines is:

70-75Gy- 75-80Gy

75-75Gy- 80-85Gy

80-85Gy- 85-90Gy

85-90Gy- 90-95Gy

2

16

Most common radiation induced cancer:

Thyroid Carcinoma

Breast Carcinoma

Leukemia

Sarcomas

2

17

30 out of 50 smokers and 10 out of 50 non smokers develop lung cancer. What is odd's Ratio

4

2.8

6

7

2

18

A 70 year old male chronic smoker is diagnosed of having cancer of the urinary bladder. It is confined to the trigone and extention is upto the submucosa. The management would be -

Complete Transurethral resction

Complete Transurethral resection with intravesical chemotherapy

Palliative Radiotherapy

Radical Cystectomy

1

19

Ten days after an exploratory laparotomy and lysis of adhesions, a patient, who previously underwent a low anterior resection for rectal cancer followed by postoperative chemoradiation, is noted to have succus draining from the wound. She appears to have adequate source control--she is afebrile with a normal white blood count. The output from the fistula is approximately 150 cc per day. Which of the following factors is most likely to prevent closure of the enterocutaneous fistula?

Previous radiation

Previous chemotherapy

Recent surgery

History of malignancy

0

20

The first step when doing a pneumonectomy for cancer of the bronchus is to:

Ligate the pulmonary vein

Ligate pulmonary aery

Divide the bronchus

Perform lymph node clearance

1

21

Which of the following anticancer drug can cause flagellated dermatitis?

Cisplatin

L-asparginase

Doxorubicin

Bleomycin

3

22

In stage III ovarian cancer patient with upper abdominal disease < 5cm, management of choice is

Debulking surgery

Mantle cell irradiation

Abdomino-pelvic radiotherapy

Neo-adjuvant chemotherapy

0

23

The commonest cancer of oral cavity is

Adenocarcinoma

Melanoma

Sarcoma

Squaous cell carcinoma

3

24

Radiation induced thyroid cancer is -

Papillary

Follicular

Anaplastic

Medullary

0

25

The most common histologic type of thyroid cancer is -

Medullary type

Follicular type

Papillary type

Anaplastic type

2

26

Which type of Human papilloma virus is most commonly associated with Cervical cancer ?

HPV 16

HPV 24

HPV 32

HPV 36

0

27

Osteosclerotic metastasis is common in cancer of:

Prostate

Lungs

Malignant melanoma

Renal cell carcinoma

0

28

Hypercalcemia is seen in which cancer

RCC

Carcinoma stomach

Small cell carcinoma lung

Hepatocellular carcinoma

0

29

The following is not one of the 4 key cell cycle regulators which are dysregulated in a variety of human cancers

P16/INK4a

Cyclin D

P21

RB

2

30

About the treatment of esophageal cancer, false statement is:

5% of patients survive 5 years after the diagnosis

The efficacy of primary radiation therapy for squamous cell carcinomas is similar to that of radical surgery

Surgical resection of all gross tumor is feasible in only 45% of cases

Chemotherapy is highly effective and sometimes curable

3

31

Monoclonal antibody used in Head and neck cancer is:-

Pembrolizumab

Trastuzumab

Rituximab

Ocralizumab

0

32

The most common histologic type of thyroid cancer is

Medullary type

Follicular type

Papillary type

Anaplastic type

2

33

High-risk breast cancer female investigation of choice is?

MRI

USG

Mammography

Clinical examination

0

34

Gene associated with autosomal dominant breast cancer?

PTEN and KAI

BRCA 1 and 2

APC

P53

1

35

8000 rads dosage in Cancer cervix is given to -

Point A

Point B

Side walls of pelvis

None of the above

0

36

Anticancer drug also used in RA, produces acrolein in urine that leads to hemorrhagic cystitis

Cyclophosphamide

Busulfan

Procarbazine

Mesna

0

37

Precancerous lesion of gall bladder is

Porcelain gall bladder

Mirrizi syndrome

Cholesterosis

Acalculous Cholecystitis

0

38

In cancer colon investigation of choice is:

CT scan

Barium enema

Colonoscopy

X-ray

2

39

Use of oral contraceptives increases the risk of which cancer -

Colon

Ovary

Breast

All of the above

2

40

Which of the following is the most common cancer of thyroid

Anaplastic carcinoma

Follicular carcinoma

Papillary carcinoma

Medullary carcinoma

2

41

M/C ovarian cancer associated with endometriosis:

Endometroid tumor

Clear cell tumor

Germ cell tumor

Brenner tumor

1

42

Antifungal used as cancer chemotherapeutic agent is :

Flucytosine

Nystatin

Voriconazole

Terbinafine

0

43

True about tongue cancer:

Most common type is adenocarcinoma

Cervical lymph node metastasis is universally present

MC site is on Lateral margin

Slurring of speech is a common complaint

2

44

A 69 year old male presents with an episode of slurring of speech which lasted for 12 hours and then resolved.He is heavy smoker having smoked 60 cigarettes per day for 40 years. He had a single episode of haemoptysis 4 weeks previously and has underlying lung cancer with brain metastases and is referred for an urgent CT chest. An ECG was performed which showed new AF. All blood tests including cardiac biomarkers were normal. Chest CT is shown. Which of the following is most probable diagnosis?

Left atrial myxoma

Left atrial thrombus

Infective endocarditis

Rhabdomyoma

1

45

A pateint with cervix cancer is mised by a screeing test and later diagnosed with advanced disease. This time interval is called

Lead time

Screening time

Serial interval

Generation time

0

46

Which of the following anticancer drug can result in "disulfiram reaction"

Lomustine

L-Asparginase

Procarbazine

Busulfan

2

47

Several weeks after surgical dissection of her left axilla for the removal of lymph nodes for staging and treatment of her breast cancer, a 32-year-old woman was told by her general physician that she had "winging" of her left scapula when she pushed against resistance during her physical examination. She told the physician that she had also experienced difficulty lately in raising her right arm above her head when she was combing her hair. In a subsequent consult visit with her surgeon, she was told that a nerve was accidentally injured during the diagnostic surgical procedure and that this produced her scapular abnormality and inability to raise her arm normally. What was the origin of this nerve?

The upper trunk of her brachial plexus

The posterior division of the middle trunk

Roots of the brachial plexus

The posterior cord of the brachial plexus

2

48

In exocrine pancreatic cancer, the commonest tumour marker to be elevated as -

CA-125

CEA

CA-15-3

CA-19-9

3

49

Preferred method of contraception for a female with family H/O ovarian cancer :

POP

Cu IUCD

OCP

Barrier method

2

50

Which of the following is a precancerous condition of cancer stomach?

Peptic ulcer

Chronic gastric atrophy

Achalasia cardia

Curling's Ulcer

1

51

All of the following anticancer drugs are cell cycle non-specific except?

Cisplatin

Vincristine

Mitomycin-C

Cyclophosphamide

1

52

All of the following are hormonal agents used against breast cancer except -

Latrazole

Exemestane

Taxol

Tamoxifen

2

53

A 70-year-old man has smoked for years despite a chronic productive cough. One day, he notices blood in his sputum and goes to see his physician. A chest x-ray reveals a mass in the left lung, which is biopsied during a fiberoptic bronchoscopy. Assuming that this patient's cancer is etiologically related to his smoking, which of the following diagnoses are most likely to be returned by the pathology laboratory?

Adenocarcinoma or bronchioloalveolar carcinoma

Adenocarcinoma or small cell carcinoma

Bronchioloalveolar carcinoma or small cell carcinoma

Small cell carcinoma or squamous cell carcinoma

3

54

Which enzymatic mutation is responsible for immortality of cancer cells?

DNA reverse transcriptase

RNA polymerase

Telomerase

DNA polymerase

2

55

Strong correlation with colorectal cancer is seen in

Peutz-Jegher's polyp

Familial polyposis coli

Juvenile polyposis

Hyperplastic polyp

1

56

Which of the following is the investigation of choice for assessment of depth of penetration and perirectal node involvement in rectal cancer?

MRI scan

CT scan pelvis

Double contrast barium enema

Transrectal ultrasound

0

57

Patient because of positive biopsy findings and negative workup undergoes a radical prostatectomy. The pathology repo reveals Gleason score 9/10 and involvement of several pelvic lymph nodes. Which is the most likely site for prostatic cancer metastasis?

Liver

Kidney

Lung

Bone

3

58

The following anticancer drug has high emetogenic potential

Chlorambucil

Vincristine

6-Mercaptopurine

Cisplatin

3

59

The following condition of GB is precancerous -

Cholesterosis

Porcelain gall bladder

Biliary atresia

Choledochal cyst

1

60

Which of the following is a metastasis suppressor gene in relation to prostate cancer

KAI - 1

NM 23

KISS

p53

0

61

The following condition of GB is precancerous

Cholesterosis

Porcelain gall bladder

Biliary atresia

Choledochal cyst

1

62

Smoking is a risk factor for all cancer except:

Esophagus

Urinary bladder

Pancreas

Gallbladder

3

63

Which of the following anticancer drugs acts by hypomethylation?

Gemcitabine

5-FU

Decitabine

Homoharringotonine

2

64

First symptom in vulval cancer is-

Pain

Pruritus

Ulceration

Bloody discharge

1

65

A 58 year old male presents with hematuria. He s diagnosed of having bladder cancer which extends muscle deep. The best treatment is

Intravesical Chemotherapy

Neoadjuvant chemotherapy followed by radical cystectomy

Radiotherapy

Tranurethral resection

1

66

A 56-year-old woman with a history of breast cancer that was treated 5 years ago with lumpectomy and radiation but with no chemotherapy returns with bone pain, fatigue, and weakness. A complete blood count reveals severe anemia, as well as decreased white blood cells and platelets. Examination of a peripheral blood smear reveals small numbers of nucleated red cells, as well as an occasional "blast" cell and myelocyte. A likely cause of the hematologic abnormalities is

chloramphenicol.

Diphyllobothrium latum infestation.

megaloblastic anemia.

myelophthisic anemia.

3

67

All the following are hormonal agents used against breast cancer EXCEPT :

Letrozole

Exemestane

Taxol

Tamoxifen

2

68

Which group of anticancer drugs temozolomide belong to :

Oral alkylating agent

Antitumor Antibiotic

Antimetabolite

Mitotic Spindle Inhibitor

0

69

According to AJCC 8th edition, staging of 2 cm size pancreatic cancer if it involves poal vein in:

T1

T2

T3

T4

0

70

Nanotechnology has found tremendous application in the diagnosis of cancers because of all of following advantages, except

Nanocrystals exibit bright, photostable fluorescence

Nonocrystals have a narrow spectrum wavelength

Peak spectrum wavelength is tunable

Nanocrystals exhibit a narrow difference between their excitation and emission peak spectra

3

71

A 30 year old female presented with unilateral breast cancer associated with axillary lymph node enlargement. Modified radical mastectomy was done, fuher treatment plan will be:

Observation and follow up

Adriamycin based chemotherapy followed by tamoxifen depending on estrogen/progesterone receptor status

Adriamycin based chemotherapy only

Tamoxifen only

1

72

Most common histological subtype of cancer endometrium is :

Mucinous carcinoma

Clear cell carcinoma

Squamous cell carcinoma

Endometrioid adenocarcinoma

3

73

Most common lung cancers in non smokers is

Squamous cell carcinoma

Bronchoalveolar carcinoma

Small cell carcinoma

Adenocarcinoma

3

74

Which of the following is FALSE regarding breast cancer during pregnancy?

Axillary lymph node metastases in 75% of affected women

Mammography is sensitivity during pregnancy

Radiation cannot be considered for treatment

Less than 25% of the breast nodules are cancerous

1

75

A patient with oral cancer, had ipsilateral lymph node measuring 2 cm, single in number with capsular spread. According to TNM staging it is included under:

Nx

N1

N2

N3

3

76

Cell cycle specific anti-cancerous drug is?

Cyclophosphamide

Vincristine

Nitrogen mustard

Doxorubicin.

1

77

Commonest cancer in burn scar is -

Sq. cell Ca

Fibrosarcoma

Adenoa Ca

Adeno-squamous Ca

0

78

The postoperative quality of life (QOL) scores of 200 prostate cancer patients have a mean of 60 and a standard detion of 10. How many patients are expected to have a QOL score between 40 and 80?

190

136

120

140

0

79

Which one of the following is the most sensitive and specific screening test to detect breast cancer?

Regular X-ray

Self breast examination

Mammography

Regular biopsy

2

80

Origin of cancer cells in Krukenberg tumour is from: March 2013

Ovarian carcinoma

Gastric carcinoma

Duodenal carcinoma

Pancreatic carcinoma

1

81

Pseudomyxoma peritonii is seen in which ovarian cancer?

Serous cystadenocarcinoma

Mucinous cystadenocarcinoma

Brenner Tumor

Fibroma

1

82

EBV is associated with which type of cancer?

Nasopharyngeal carcinoma

Epidermodysplasia

Kaposi sarcoma

null

0

83

Cadmium can cause all cancer except-

Lung

Pancreas

Prostate

Skin

3

84

Most common type of HPV associated with cervical cancer ?

6, 11

5, 8

16, 18

6, 8

2

85

Which of the following pathologic findings is/are the strongest contraindication to breast preservation (lumpectomy with breast radiation) as primary treatment for a newly diagnosed breast cancer?

Grade 3, poorly differentiated, infiltrating ductal carcinoma

Extensive intraductal cancer around the invasive lesion

Tumor size less than 3 cm

Positive surgical margin for invasive cancer

3

86

If a 95% confidence interval for prevalence of cancer smokers aged> 65 years is 56% to 76%, the chance that the prevalence could be less than 56% is-

Nil

44%

2.50%

5%

2

87

Which of the following is a triple negative breast cancer -

Colloid Cancer

Secretory cell cancer

Acinic Cell Carcinoma

Mucinous Carcinoma

1

88

Example for radiation induced cancer is:

Papillary carcinoma thyroid

Follicular carcinoma thyroid

Lymphoma

Hepatoma

0

89

A 70-year-old woman with a history of ovarian cancer presents with diarrhea. She completed radiation therapy for her cancer 3 months ago. Physical examination shows cachexia, hyperactive bowel sounds, and generalized pallor. The stools are found to contain blood. A CBC shows decreased hemoglobin (7.8 g/dL) and decreased mean corpuscular volume (70 mm3). Which of the following is the most likely cause of GI bleeding in this patient?

Angiodysplasia

Hemorrhoids

Ischemic colitis

Radiation enterocolitis

3

90

Arrange the following causes of NCD deaths as per decreasing order of frequency? A. Cancers B. Cardiovascular diseases C. Diabetes D. Respiratory diseases

A>D>C>B

D>A>B>C

B>A>D>C

C>B>D>A

2

91

Virus causing cervical cancer in the ectocervix -

HPV16

HPV17

HPV11

HPV19

0

92

Which of the following strategy has been recommended to reduce the heredity risk for ovarian cancer in women with BRCA -1 and BRCA - 2 mutations :

Use of oral contraceptive pills

Screening with transvaginal ultrasound

Screening with CA - 125

Prophylactic oophorectomy

3

93

Precancerous lesion of bone among the following is

Paget disease

Chronic osteomyelitis

Benign giant cell tumor

All of the above

3

94

Cancer management in which of following malignancies has dramatically increased the survival?

Esophagus carcinoma

Glioblastoma multiforme

ALL in children

Cholangiocarcinoma

2

95

Example for radiation induced cancer is ?

Papillary carcinoma thyroid

Follicular carcinoma thyroid

Lymphoma

Hepatoma

0

96

Smoking predisposes to all of the following cancers except -

Carcinoma larynx

Carcinoma bladder

Carcinoma stomach

Lymphoma

3

97

A 70-year-old male Rohan with advanced visceral cancer dies of extensive myocardial infarction. Autopsy also reveals sterile non-destructive vegetations along the mitral leaflet edges. The pathogenesis of this patient's vegetations is most similar to that of:

Hypercalcemia of malignancy

Distant metastases

Trousseau syndrome

Raynaud's phenomenon

2

98

A patient with cancer developed extreme degree of radiation toxicity. Further history revealed that the dose adjustment of a particular drug was missed during the course of radiotherapy. Which of the following drugs required a dose adjustment during radiotherapy in order to prevent radiation toxicity?

Vincristine

Dactinomycin

Cyclophosphamide

6- Mercaptopurine

1

99

Anticancer drug causing nephrotoxicity: September 2009

Imitanib

Irinotecan

fosfestrol

Cisplatin

3