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Breast cancer is epidemiologically commoner with ?

Smoking

Nulliparity

Oral contraceptives

Multiparity

Which of the following is given to treat thrombocytopenia secondary to anti cancer therapy and is known to stimulate progressive megakaryocytes

Filgrastin

Oprelvekin

Erythropoietin

Iron dextran

The gene for Breast Cancer (BRCA) is present on chromosome:

21

17

15

9

Papillary carcinoma thyroid: a. Most common thyroid cancer b. Psammoma bodies seen c. Encapsulated d. Blood borne metastasis is common

ab

bc

cd

da

Least common quadrant in cancer breast is

Upper outer

Lower outer

Sub areolar

Lower inner

The following anticancer drug is naturally obtained from plants?

Cisplatin

Tretinoin

Vincristine

Omalizumab

Which of the following test is unable to differentiate between 'in situ' breast cancer and invasive disease

Core needle biopsy

FNAC

Excisional biopsy

A 65 year old male was diagnosed with prostate cancer three years back and was treated by surgery and hormone therapy. Presently he has developed urinary symptoms and progressive backache. What is the tumor marker, which can be indicative of disease relapse -

CA 125

Beta-HCG

Carcinoembryonic antigen (CEA)

PSA

Bladder cancer can occur in those who are working in chimney for 25 years. Which is the best study for this relationship ?

Meta-analysis

Cross-sectional study

Randomized control trial with double blinding

Coho study

Which of the following is a new drug approved for the treatment of Breast Cancer?

Trametinib

Ruxolitinib

Palbociclib

Cobimetinib

Anti cancer drug causing nephrotoxicity

Cyclophosphamide

Busulfan

Cisplatin

Procarbazine

First symptom of vulval cancer is -

Pruritis

Ulcerated lesion

Mass in the groin

White discharge

Increased risk of cancer is seen in which of the following?

Fibroadenoma of breast

Bronchial asthma

Chronic ulcerative colitis

Leiomyoma of the uterus

Hot flashes in prostate cancer are seen after treatment with:a) Surgical castrationb) Androgen receptor blockerc) Radical prostatectomyd) Estrogen and Cyproterone acetate

ab

a

ad

bc

Treatment modalities for ovarian cancers is :

Staging laparotomy

Surgery

Chemotherapy

Combined approach

Cancers are usually associated with:

Mutations in intronic genes

Hypomethylation of oncogenes

Methylation of tumor suppressor genes

Loss of heterogenicity

All of the following are pre-cancerous conditions of the lids except

Solar keratosis

Naevus

Xeroderma pigmentosa

Carcinoma-in-situ

A 47-year-old woman with a family history of breast cancer mutations in the BRCA1 and BRCA2 genes has made a decision to have an elective hysterectomy as a prophylactic treatment. During ligation of the uterine artery which of the following adjacent structures must the surgeon be careful not to injure?

Ureter

Internal iliac artery

Internal iliac lymph nodes

Obturator nerve

Majority of bladder cancers are:

Adenocarcinoma

Adenosquamous carcinoma

Squamous carcinoma

Transitional cell carcinoma

Preferred treatment approach for locally advanced head and neck cancers is ?

Radiotherapy alone

Surgery alone

Induction chemotherapy followed by radiotherapy / surgery

Concomitant chemotherapy with radiotherapy

Increased risk of cancer is seen in

Fibroadenoma of breast

Bronchial asthma

Chronic ulcerative colitis

Leiomyoma of the uterus

All of the following agents are used in the treatment of prostate cancer Except

Diethylstilbestrol (DES)

Leuprolide

Flutamide

Tamoxifen

Which of the following type of thyroid cancer metastasize to the bone MOST commonly?

Follicular

Papillary

Huhle cell tumor

Anaplastic

All of the following are components of corpus cancer syndrome, EXCEPT:

Multiparity

Diabetes

Hypeension

Obesity

Which of the following is used to treat hormone- responsive breast cancer?

Cyptroterone acetate

Clomiphene citrate

Diethylstibestrol

Tamoxifen

Drug used in cancer chemotherapy induced vomiting is ?

Aprepitant

Dexamethasone

Ondansetron

All of the above

Drug of choice for Neutropenia due to cancer chemotherapy:

Vitamin B-12

IL 11

Filgrastim

Erythopoie tin

Which of the following anticancer drug causes hemolytic uremic syndrome:

Vincristine

Vinblastine

Cisplatin

Mitomycin C

Smoking increase the risk of all of the following cancer's, except:

Ca Larynx

Ca Nasopharynx

Ca Bladder

Ca Esophagus

Occupational cancer involve following organs except -

Lung

Breast

Bladder

Liver

Neuromuscular disorder is related to which type of lung cancer ?

Adeno carcinoma

Squamous cell carcinoma

Small cell carcinoma

Bronchoavelolar carcinoma

Which of the following is true about medullary cancer thyroid?

MET gene Positive

Elevated levels of serum calcitonin+

MEN I syndrome associated

Most common thyroid cancer

The cancerogenic chemical that has a very long latent period is -

Benzopyrine

Vinyl chloride

Asbestos

Estrogens

All of the following are precancerous lesions for carcinoma oral cavity except:-

Erythroplakia

Speckled erythroplakia

Discoid lupus erythematosus

Chronic hyperplastic candidiasis

Roopmati, A 56–year–old female with lymph-node-positive breast cancer was treated with systemic chemotherapy. Four weeks later, she developed frequent urination, suprapubic pain, dysuria, and hematuria. Which of the following could have prevented this patient's condition?

Folinic acid

Mesna

Dexrazoxane

Amifostine

Commonest cancer in which metastasis is seen in the brain is -

Breast

Lung

Kidney

Intestines

Familial clustering of pancreatic cancer has been repoed, and a growing number of inherited genetic defects are recognized to increase pancreatic cancer risk. The disorder with maximum risk of pancreatic cancer by the age of 70 is:

Peutz-Jeghers syndrome

Hereditary pancreatitis

Familial atypical multiple-mole melanoma syndrome

Hereditary breast and ovarian cancer

The stage of cancer endometrium with invasion of 10 mm of myometrium is:

Ia

Ib

IIb

IIa

Risk for endometrial cancer is:a) Obesityb) Pregnancy before 20 years agec) PCODd) Combined OC pillse) Artificial menopause

a

ac

ad

b

Most common site for colon cancer is ?

Caecum

Transverse colon

Rectosiigmoid

Ascending colon

Which radio isotope is used for treating bone cancer?

Sr

I 123

Ga

Tc

Occupational cancer involve following organs except-

Lung

Breast

Bladder

Liver

Most common radio-isotopes used as a source for external beam radiotherapy in the treatment of cancer:

Strontium-89

Radium-226

Cobalt-59

Cobalt-60

Methotrexate is what class of anti cancer drug -

Alkylating agents

Antimetabolites

Microtubule damaging agents

Topoisomerase inhibitors

Lung cancer is an industrial hazard in/for –

Chimney sweepers

Aniline industry

Gas industry

Benzol industry

Nitrosoureas used in the treatment of cancer are?

Carmustine

5FU

Methotrexate

Cisplatin

Which of the following are associated with Bladder cancer

Naphthylamines

Nickel

Arsenic

Lead

PAP smear is used for screening of Cervical cancer. It is classified under which level of prevention:-

Primary

Secondary

Teiary

Primordial

Most common anatomocal lesion of tongue cancer is

Anterior third

Lateral margin

Dorsum

Posterior third

The most common pure germ cell cancer of the ovary is:

Choriocarcinoma

Dysgerminoma

Embryonal cell tumor

Malignant teratoma

A 55-year-old woman with metastatic lung cancer presents with dyspnea and pedal edema. On examination, the JVP is at 10 cm, with a negative Kussmaul sign. The heart sounds are diminished and the lungs have bibasilar crackles. The ECG shows QRS complexes of variable height.For the above patient with shortness of breath and peripheral edema, select the most likely diagnosis.

cardiac tamponade

constrictive pericarditis

restrictive cardiomyopathy

right ventricle myocardial infarction (RVMI)

Which of the following is the most common type of head and neck cancer

Squamous cell carcinoma

Adenocarcinoma

Adenoid cystic carcinoma

Melanoma

Immunohistochemical markers are used in various cancers. Her-2/Neu immunohistochemistry in breast cancer is used for:

Diagnosing purpose

Predicting response to therapy

Screening of Ca breast

Recurrence of Ca breast

Precancerous lesion of gall bladder is-

Porcelain gall bladder

Mirrizi syndrome

Cholesterosis

Acalculous Cholecystitis

A 45-year-old premenopausal woman undergoes a left breast lumpectomy for a 1.5 cm, lymph node positive, hormone sensitive invasive breast cancer. She receives chemotherapy, radiotherapy, and is on tamoxifen. Recommended follow-up after therapy should always include:

Blood tumor markers drawn every 3-6 months after treatment.

Routine monitoring of liver function tests (LFTs) every 3-6 months after treatment.

Yearly bone scans.

Routine clinical examination every 3-6 months for the first 5 years after treatment as well as continued yearly mammography.

Most important prognostic factor of cancer esophagus:

Length of growth

Depth of involvement

Histology grading

Immunohistochemistry

Cancer management in which of following malignancies has dramatically increased the survival ?

Esophagus carcinoma

Glioblastoma multiforme

ALL in children

Cholangiocarcinoma

A 67-year-old woman is evaluated for obstructive jaundice. The cholangiographic findings indicate that she has a cancer of the lower end of the CBD. Clinical examination would most likely reveal which of the following?

Enlarged gallbladder

Shrunken gallbladder

Enlarged pancreas

Shrunken pancreas

A study has been done to establish the relationship between smoking and lung cancer. It was found that the association was more in people who exercise less and less in people exercise more. In this situation, exercise is a

Bias

Confounding

Effect modifier

Collinear factor

Which of the following stage of breast cancer corresponds with following features? 1. Breast mass of 6 X 3 cm 2. Hard mobile axillary lymph node on ipsilateral side 3. Ipsilateral supraclavicular lymph node

T4 N2 M0

T3 N1 M1

T3 N3 M0

T3 N2 M1

Most common type of renal cancer is

Medullary

papillary

chromophobe

Clear cell cancer

Whole-body iodine scan after total thyroidectomy is not recommended for which thyroid cancer ?

Papillary thyroid cancer

Anaplastic thyroid cancer

Medullary thyroid cancer

Follicular thyroid cancer

Among males, which of the following is the most common cancer by incidence?

Prostate

Colon

Lung

Oropharynx

Worst prognosis among all the breast cancer is

Mucinous carcinoma

Triple negative breast carcinoma

Inflammatory breast carcinoma

Medullary breast carcinoma

Predisposing factor for esophageal cancer is all except:

Mediastinal fibrosis

Diveicula

Caustic alkali burn

HPV

Intestinal polyps that can potentially grow into cancer

Adenomatous polyp

Hyperplastic polyp

Juvenile polyp

Hamartomatous polyp

A 67-year-old woman is being treated for metastatic ovarian cancer with cisplatin and cyclophosphamide. To prevent nausea and vomiting, she is given an agent that selectively antagonizes 5-hydroxytryptamine-3 (5-HT3) receptors. Which of the following drugs is this patient most likely taking?

Dimenhydrinate

Dronabinol

Metoclopramide

Ondansetron

The MOST frequent cancer associated with asbestos exposure?

Lung cancer

Pleural mesothelioma

Peritoneal mesothelioma

Adenocarcinoma esophagus

If rapidly progressive cancers are missed by a screening test, which type of bias will occur?

Lead-time bias

Length bias

Selection bias

Surveillance bias

rug used in estrogen dependent breast cancer

Tamoxifen

Clomiphene citrate

Estrogen

Adriamycin

Which of the following drugs has been found to increase the survival in locally advanced pancreatic cancer?

Doxorubicin

Streptozocin

Gemcitabine

Paclitaxel

Antiemetic used in vomiting induced by anticancer drugs is:

Ondansetron

Cisapride

Metoclopramide

Tritluopromazine

Cells cultured from patients with this disorder exhibit low activity for the nucleotide excision repair process. This autosomal recessive genetic disease includes marked sensitivity to sunlight (Ultra voilet light) with subsequent formation of multiple skin cancers and premature death, the disorder is –

Acute intermittent porphyria

Alkaptonuria

Xeroderma pigmentosa

Ataxia - Telangiectasa

Cancer cells derive nutrition from:

Anaerobic glycolysis

Oxidative phosphorylation

Increase in mitochondria

Aerobic Glycolysis

In a well designed clinical trial of treatment of ovarian cancer, remission rate at one year is similar for a new drug and usual care, The P-value is 0.4. This means that

Both treatments are effective

Neither treatment is effective

The statistical power of study is 60%

The best estimate treatment effect is 0.4

Anticancer drugs of plant origin is/are : a) Vincristine b) Isotretinoin c) Bleomycin d) Methotrexate

ac

a

b

ab

Point A and point B Manchester location are important for treatment of_______ cancer.

Cervix

Vagina

Ovary

All of the above

Which of the following is the most common histologic type of thyroid cancer ?

Anaplastic type

Medullary type

Follicular type

Papillary type

Pulsatile mets seen in w hich cancer-

Lung cancer

Prostate cancer

Renal cancer

Breast cancer

Which one of the following is the most sensitive and specific screening test to detect breast cancer-

Regular X-ray

Self breast examination

Mammography

Regular biopsy

Which cancer develops in chronic ulcer -

Malignant melanoma

Basal cell CA

Squamous cell CA

Kaposi sarcoma

A 26-year-old man is diagnosed with adeno- carcinoma of the stomach. He wants to know what could have caused him to develop this condition. He does an internet search. Which of the following is a risk factor for developing gastric cancer?

Exposure to ionizing radiation

Blood group B

A diet high in fiber

pylori infection

Lynch syndrome is associated with cancers of :

Breast, colon, ovary

Breast, endometrium, ovary

Breast, colon, endometrium

Colon, endometrium, ovary

The most indicative test for prostate cancer is:

A thorough digital rectal examination

Magnetic resonance imaging (MRI)

Excretory urography

Prostate-specific antigen

Which of the following mutations in a tumour suppressor agent by apoptosis regulation causes breast cancer?

p43

p53

p73

p83

Skin cancers develop due to sunlight exposure induced by

UVA rays

UVD rays

UVC rays

UVB rays

Hypercalcemia occurs in which type of lung cancer?

Oat cell

Giant cell

Squamous cell

Alveolar cell

All are precancerous for carcinoma bladder except -

Tuberculosis bladder

Aniline dyes

Schistosomiasis

All

A patient is receiving external beam radiation for treatment of metastatic endometrial cancer. The treatment field includes the entire pelvis. Which of the following tissues within this radiation field is the most radiosensitive?

Vagina

Ovary

Bladder

Rectum

Which thyroid cancer Occurs after radiation exposure?

Follicular

Papillary

Medullary

Anaplastic

To detect distant metastasis in pancreatic cancer the imaging modality which is BEST used is:

MRCP

Dual phase, contrast-enhanced spiral CT

EUS

Positron-emission tomography with fluorodeoxyglucose positron emission tomography

Most impoant dose limiting toxicity of cancer chemotherapy is

Gastronomy toxicity

Neurotoxiciity

Bone marrow suppression

Nephrotoxicity

Bellini duct cancer is seen in which of the following?

Liver

Kidney

Hea

Spleen

Diagnostic tumor marker for medullary thyroid cancer :

BRAF

VMA

Calcitonin

Melatonin - 1

The phenomenon by which the cancer cells are able to sustain and proliferate under adverse conditions of hypoxia is ?

Warburg

Wanton

Wormian

Wolf

A lady undergoes radical hysterectomy for stage lb ca cervix. It was found that cancer extends to lower pa of body of uterus and upper pa of cervix next step of management will be:

Chemotherapy

Radiotherapy

Chemoradiation

Follow-up

Investigation of choice for colon cancer is

CECT

Barium enema

Barium swallow

Colonoscopy

All of the following are risk factors for the development of Endometrial cancer, EXCEPT:

Fibromyoma

Endometrial hyperplasia

Dysgerminoma

Granulosa cell tumor

Which of the following is a cardiotoxic anticancer drug?

Bleomycin

Doxorubicin

5 FU

Dactinomycin

Which of the following cancer can cause referred otalgia i.e. Referred pain in the Ear?

Ca larynx

Ca pharynx

Ca oral cavity

All of the above