sayyid14/MedMCQACancer · Datasets at Hugging Face

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100	Most common cancer in men is	Bladder cancer	Colorectal cancer	Prostate cancer	Oral cancer	2
101	The study of smoking as a cause of lung cancer, 90 cases were taken, 75 were smokers and among 100 controls 40 were smokers. Calculate the odds ratio ?	2	4.5	7.5	10	2
102	The commonest pre-malignant condition of oral cancer is	Leukoplakia	Aphthous ulcer	Lichen planus	Erythro-leukoplakia	0
103	Which Lung Cancer resembles Pneumonia with Air Bronchogram sign?	Squamous Cell Ca	Large Cell CA	Small Cell Ca	Bronchoalveolar CA	3
104	For the following statements, select the most likely type of thyroid cancer.Has the best prognosis of all thyroid malignancies.	anaplastic thyroid cancer	follicular cancer of the thyroid	lymphoma of the thyroid	papillary cancer of the thyroid	3
105	Most common histological subtype of lung cancer associated with pancoast tumor?	Small cell cancer	Squamous cell cancer	Adenocarcinoma	Carcinoid tumor	1
106	Roopa Devi, a 65-year-old female with lymph-node-positive breast cancer was treated with systemic chemotherapy. Four weeks later, she developed frequent urination, suprapubic pain, dysuria, and hematuria. Which of the following could have prevented this patient's condition?	Folinic acid	Mesns	Dexrazoxane	Amifostine	1
107	All are precancerous lesions of oral cavity except	Leukoplakia	Erythroplakia	Diffuse oral submucous fibrosis	Diffuse aphthous ulcers	3
108	A 25-year-old woman has recently moved to a new city. She comes today for her first routine visit and annual physical assessment. She feels well, reports no new symptoms, and her past medical history is negative. Her only medication is the oral contraceptive pill; she is currently in university and drinks on a social basis. She reports smoking in her teens but quit 7 years ago. The physical examination is completely normal. She asks you about screening tests for cancer at her age. Which of the following cancer screening tests are recommended for her age group?	mammography every 5 years	Pap smear at least every 3 years	stool for occult blood	chest x-ray (CXR) every 3 years	1
109	A 50-year-old woman is discovered to have metastatic breast cancer. One week after receiving her first dose of chemotherapy, she develops bacterial pneumonia. Which of the following best explains this patient's susceptibility to bacterial infection?	Depletion of serum complement	Impaired neutrophil respiratory burst	Inhibition of clotting factor activation	Neutropenia	3
110	The use of tamoxifen for breast cancer can cause all of the following adverse effects, except:	The use of tamoxifen for breast cancer can cause all of the following adverse effects, except:	Endometrial carcinoma	Carcinoma in contralateral breast	Cataract	2
111	Women with Plummer Vinson develops which cancer ?	Pyriform fossa	Esophagus	Subglottis	Epiglottis	1
112	A 33-year-old woman discovers a lump in her left breast on self-examination. Her mother and sister both had breast cancer. A mammogram demonstrates an ill-defined density in the outer quadrant of the left breast, with microcalcifications. Needle aspiration reveals the presence of malignant, ductal epithelial cells. Genetic screening identifies a mutation in BRCA1. In addition to cell cycle control, BRCA1 protein promotes which of the following cellular functions?	Apoptosis	Cell Adhesion	DNA Repair	Gene Transcription	2
113	Stage lb cervical cancer is diagnosed in a young woman. Assuming that the cancer is confirmed to the cervix and that intraoperative biopsies are negative, which of the following structure would not be removed during the radical hysterectomy?	Uterosacral and uterovesical ligaments	Pelvic nodes	The entire parametrium on both sides of the cervix	Both ovaries	3
114	A 34-year-old man complains of sudden attacks of dizziness, blurred vision, and excruciating headaches of 4 months in duration. During one of these attacks, his blood pressure was 180/120 mm Hg. The patient's father had been treated for thyroid cancer about 15 years ago. Laboratory studies show normal serum levels of aldosterone, renin, and angiotensin. A 24-hour urinalysis reveals increased metanephrines. Episodic hypeension in this patient is most likely caused by a tumor in which of the following endocrine organs?	Adrenal	Kidney	Parathyroid	Pituitary	0
115	In which the following head and neck cancers, is lymph node metastasis least common	Tongue	Buccal mucosa	Hard palate	Lower alveolus	2
116	Cancer cells express Telomerase which is:	RNA-dependent DNA polymerase	DNA-dependent DNA polymerase	DNA-dependent DNA polymerase	RNA-dependent DNA polymerase	3
117	Young's operation of Penile cancer is	Total amputation of penis with Bilateral ilio - inguinal Block dissection	Total amputation of penis with Unilateral ilio - inguinal Block dissection	Partial amputation of penis with Bilateral ilio - inguinal Block dissection	Partial amputation of penis with Unilateral ilio - inguinal Block dissection	2
118	Which of the following statements are True or False? 1. Genetic polymorphisms of the P450 enzyme system, specifically CYP1A1, or chromosome fragility are associated with the development of lung cancer. 2. Cigarette smoking increases the risk of squamous and small cell lung cancer cell types only. 3. Varenicline-nicotinic acetylcholine receptor paial agonist is used for nicotine dependence. 4. Low-dose, noncontrast, thin-slice helical or spiral chest CT has emerged as a possible new tool for lung cancer screening. 5. Extrathoracic metastatic disease is found at autopsy in 20% of patients with squamous carcinoma.	1,2,3 True & 4,5 False	1,3,4 True & 4,5 False	2,4,5 True & 1,3-False	2,5 True & 1,3,4-False	1
119	Most common type of lung cancer is?	Small cell carcinoma	Adenocarcinoma	Squamous cell carcinoma	Large cell carcinoma	1
120	A 50 year old male with positive family history of prostate cancer has come to you for a screening test. The MOST sensitive screening test to pickup prostate cancer is:	DRE	PSA	DRE + PSA	Endorectal Coil MRI with TtW and T2W images	2
121	The most likely cause for suture leak after colon resection and anastomosis for cancer sigmoid is ?	Subclinical malnutrition	Infection of anastomotic site	Mechanical disruption due to colonic pressure and contractility	Ischaemia	3
122	A 65-year-old man dies after a protracted battle with meta- static colon carcinoma. At autopsy, the liver is filled with multiple nodules of cancer, many of which display central necrosis (umbilication). Which of the following best explains the pathogenesis of tumor umbilication in this patient?	Biphasic tumor	Chronic inflammation	Granulomatous inflammation	Ischemia and infarction	3
123	A patient was given radiotherapy for head and neck cancer. After 6 months chemotherapy was staed. The patient presented with the features shown in Figure after sta of chemotherapy. It is likely due to which drug?	Doxorubicin	Cisplatin	Imatinib	Methotrexate	0
124	Lung cancer most commonly associated with smoking ?	Small cell carcinoma	Adenocarcinoma	Squamous cell carcinoma	Large cell carcinoma	2
125	Cancer caused by chronic parasitic infection -	Cholangiocarcinoma	Hepatic cell Ca	Ca GB	Ca pancreas	0
126	Following surgical removal of a firm nodular cancer swelling in the right breast and exploration of the right axilla, on examination the patient was found to have a winged right scapula. Most likely this could have occurred due to injury to the :	Subscapular muscle	Coracoid process of scapula	Long thoracic nerve	Circumflex scapular artery	2
127	A 50-year-old woman who was obese and hypertensive, came with complaints of bleeding and abdomen pain, diagnosed to be endometrial cancer. Which of the following gene is mutated?	P53	PTEN	Beta catenin	CHD4	1
128	BRAF mutation is seen in 60% of cancers of	Malignant melanoma	Basal cell carcinoma	Squamous cell carcinoma	Teratoma	0
129	In a case-control study of a suspected association between breast cancer and the contraceptive pill, all of the following are true statements except-	The control should come from a population that has the same potential for breast cancer as the cases	The control should exclude women known to be taking the pill at the time of the survey	All the controls need to be healthy	The attributable risk of breast cancer resulting from the pill may be directly measured	3
130	A 78-year-old man underwent surgical repair of an abdominal aoic aneurysm. Postoperatively he developed left lower quadrant pain along with urgency to defecate and had frequent episodes of passage of bright red blood per rectum. He has a history of prostate cancer for which he had received radiation therapy several years ago. Colonoscopy findings of the patient are shown below.X ray abdomen was also done. What is the most likely cause of his symptoms?	Radiation proctitis	Clostridium difficile colitis	Ischemic colitis	Acute diveiculitis	2
131	A 55-year-old woman with cancer of the cervix undergoes hysterectomy and is found to have pelvic lymph nodes involved with cancer. She then receives a course of external beam radiation (4500 rads). When the physician counsels her prior to her radiation treatment, she should be told of all the possible complications of radiation enteritis. Which of the following is generally not associated with radiation injury?	Malabsorption	Intussusception	Ulceration	Fistulization	1
132	Inherited cancer syndrome include all except?	Retinoblastom	Neurofibroma	Xeroderma pigmentosa	Familial polyposis coli	1
133	Marker for ovarian cancer is	CA 125	Ca 19 - 19	Ca 15 - 5	Hypercalcemia	0
134	Anti cancer drug causing nephrotoxicity ?	Cyclophosphamide	Busulfan	Cisplatin	Procarbazine	2
135	Anticancer drug with disulfuram like action -	Procarbazine	Nitrosurea	5 FU	Methotrexate	0
136	In a prospective study comprising 10,000 subjects, 6000 subjects were put on beta carotene and 4000 were not. 3 out of the first 6000 developed lung cancer and 2 out of the second 4000 developed lung cancer. What is the interpretation of the above results ?	Beta carotene is protective in lung cancer	Beta carotene and Lung cancer have no relation to each other	The study design is not sufficient to draw any meaningful conclusions	Beta carotene is carcinogenic	1
137	Which of the following test is unable to differentiate between 'in situ' breast cancer and invasive disease:	Core needle biopsy	FNAC	Excisional biopsy	null	1
138	Antifolate cancer drug are -	Methotrexate	Azathioprine	Cycl osporin	Vincristine	0
139	The American Cancer Society recommends annual screening mammography for healthy women older than___________years NOT RELATED-GYN	30	40	50	55	1
140	Roughly what percentage of patient with metastatic epithelial ovarian cancer will be benefited by treatment with an alkylating agent :	Less than 10 percent	25 to 49 percent	50 to 74 percent	75 to 89 percent	2
141	Most common type of cervical cancer	Squamous cell CA	Small cell CA	Adeno CA	Adenoma	0
142	A drug used in estrogen-dependent breast cancer	Clomiphene citrate	Tamoxifen	Estrogen	Adriamycin	1
143	Which of the following drugs is not used for the treatment of cancer	Cyclophosphamide	Cyclosporine	Methotrexate	6-mercaptopurine	1
144	A 54-year old woman complains of hot flashes and night sweats. Her last menstrual period was 2 years ago. She also has migraine headaches and a family history of breast cancer her maternal aunt. What is the appropriate treatment for her?	Hysterectomy	Endometrial biopsy	Medroxyprogesterone acetate	Estrogen cream	2
145	During endoscopic biopsy of a distal esophageal cancer, perforation of the esophagus is suspected when the patient complains of significant new substernal pain. An immediate chest film reveals air in the mediastinum. You would recommend	Placement of a nasogastric tube to the levels of perforations, antibiotics, and close observation	Spit fistula (cervical pharyngostomy) and gastrostomy	Left thoracotomy, pleural patch oversewing of the perforation, and drainage of the mediastinum.	Esophagogastrectomy celiotomy and right thoracotomy	3
146	A patient with cancer developed extreme degree of radiation toxicity. Fuher history revealed that the dose adjustment of a paicular drug was missed during the course of radiotherapy. Which of the following drugs required a dose adjustment during radiotherapy in order to prevent radiation toxicity?	Vincristine	Dactinomycin	Cyclophosphamide	6-Mercaptopurine	1
147	A 35 year old man feels that he is about to die because he is suffering from gastric cancer. All his radiological investigations prove the contrary. Which is the most probable diagnosis?	Somatic symptom disorder	Illness anxiety disorder	Conversion disorder	Delusional disorder	1
148	Anticancer drug causing lung fibrosis is:	Bleomycin	Cisplatin	Fulvestrant	Tamoxifen	0
149	Down's syndrome predisposes to _____cancer –	AML	CML	ALL	All of these	3
150	Which of the following radioisotopes is commonly used as a source for external beam radiotherapy in the treatment of cancer patients –	Strontium–89	Radium–226	Cobalt–59	Cobalt–60	3
151	The mechanism of anticancer action of fluorouracil is:	Cross linking of double stranded DNA and the resulting inhibition of DNA replication and transcription	Cytotoxicity resulting from a metabolite that interferes with the production of dTMP	Irreversible inhibition of dihydrofolic acid reductase	Inhibiting the formation of mitotic spindle	1
152	Anticancer macrolide is	Sirolimus	Cycloserine	Roxythromycin	Azithromycin	0
153	Killing of Thyroid Cancer cells By I-131 is mainly by	Alpha Rays	X rays	Beta Rays	Gamma Rays	2
154	Schistosoma haematobium is most commonly associated with which of the following bladder cancers?	Squamous cell carcinoma	Adenocarcinoma	Small cell carcinoma	Transitional cell carcinoma	0
155	30 yrs female presented with unilateral breast cancer associated with axilary lymph node enlargement. Modified radical mastectomy was done, fuhur traeatment plan will be	Observation and followup	Adriamycin based chemotherapy followed by tamoxifen depending on estrogen\/progesterone receptor status	Adriamycin based chemotherapy only	Tamoxifen only	1
156	Morphologically diagnostic feature of cancer cells -	T Size	T Mitotic activity	T Cytoplasm	T Lysosomes	1
157	In a post operative case of early stage endometrial cancer, radiation is advised in	Stage 1A Grade I	Stage IA Grade II	Stage IA Grade III	All the above	2
158	30 yrs female presented with unilateral breast cancer associated with axilary lymph node enlargement. Modified radical mastectomy was done, fuher treatment plan will be	Observation and followup	Adriamycin based chemotherapy followed by tamoxifen depending on estrogen/progesterone receptor status	Adriamycin based chemotherapy only	Tamoxifen only	1
159	A 26-year-old healthy man comes to your clinic for an annual wellness examination. He does not take any medications. He smokes half pack of cigarettes daily. He tells you that his father died of colon cancer at the age of 45. He also has a 25-year-old cousin who recently had colonoscopy for rectal bleeding was found to have multiple polyps and is scheduled for total colectomy. Your patient wants to know if he can inherit colon cancer and if there is a way to find out if he is at risk. You talk to him about how some cancers can be caused by genetic mutations. For what genetic mutation is this patient at highest risk?	MEN1	RET	APC	MSH	2
160	Most common type of thyroid cancer is:	Papillary carcinoma	Follicular carcinoma	Anaplastic carcinoma	Medullary carcinoma	0
161	In the reconstruction following excision of previously irradiated cheek cancer the flap will be	Local tongue	Cervical	Forehead	Pectoralis major myocutaneous	3
162	A 37-year-old woman is suffering from carcinoma of the uterus(fundus area) . Cancer cells are likely to metastasize directly to which of the following lymph nodes?,	External iliac nodes	Internal iliac nodes	Superficial inguinal nodes	Aoic (lumbar) nodes	2
163	A 54 year old man presents to a physician with headaches. A complete blood count demonstrates a hematocrit of 62%. The peripheral smear showed normocellular erythrocytes, with increased reticulocytes and nucleated red cells. Bone marrow biopsy demonstrates increased numbers of erythrocytic precursors. Cancer of which of the following organs would be most likely to cause these findings?	Colon	Kidney	Ovary	Prostate	1
164	Which of the following Human papilloma virus subtypes are not covered by Quadrivalent Anti-cervical cancer vaccine?	Type 6	Type 7	Type 11	Type 16	1
165	Drug useful in breast cancer is ?	Tamoxifen	Cyproterone	Testosterone	Chlorambucil	0
166	An old woman is required to receive 4 cycles of cancer chemotherapy. After her first cycle, she developed chemotherapy induced thrombocytopenia. Then in the next cycle, it would be appropriate to give this patient:	Darbopoietin alpha	Filgrastim (G-CSF)	Iron dextran	Oprelvekin (IL-11)	3
167	A tableau was held in a village to educate the villagers about early detection of oral cancer. This type of health education is called:	Symposium	Seminar	Role play	Learning by doing	2
168	Which of the following is not a premalignant condition oral cancer?	Leukoplakia	Erythroplakia	Oral submucous fibrosis	Systemic Sclerosis	3
169	All of the following anticancer drugs are Cell cycle NON-specific EXCEPT: - March 2013	Doxorubacin	Vincristine	Mitomycin-C	Cyclophosphamide	1
170	Most common cancer of anus:	Adenocarcinoma	Squamous cell CA	Basal cell CA	Melanoma	1
171	Which of the following is not a premalignant condition oral cancer-	Leukoplakia	Erythroplakia	Oral submucous fibrosis	Systemic Sclerosis	3
172	Commonest cancer in burn scar is	Squamous cell carcinoma	Fibrosarcoma	Adenocarcinoma	Adenosquamous carcinoma	0
173	Breast cancer mainly spreads to the veebrae	Aerial route	Direct Invasion	Batsons venous plexus	Via Axillary lymph nodes	2
174	This type of endometrial hyperplasia leads to increased risk of endometrial cancer:	Simple	Proliferative	Atypical	Secretive	2
175	Early gastric cancer generally indicates :	Gastric adencarcinoma detected early	Gastric adenocarcinoma confined to the mucosa	Gastric adenocarcinoma confined to the mucosa & submucosa	Gastric adenocarcinoma less than 1 cm. In size	2
176	Radiation is most commonly associated with which of the following cancer ?	Leukemia	Lymphoma	Lung carcinoma	Osteoblastoma	0
177	White lesion with definite precancerous potential	Leukoplakia	Discoid lupus Erythematosus	Lichen Planus	All of the above	0
178	Mammography was performed in 45 year old female for screening of breast cancer. The finding is suggestive of	Benign lesion	Malignant lesion	Indeterminate	No opinion can be given	1
179	Most commonly associated human papilloma virus with Cancer Cervix is?	HPV 16	HPV 24	HPV 32	HPV 36	0
180	Most common bladder cancer -	SCC	Transitional cell carcinoma	Sarcoma	Lymphoma	1
181	Point A and point B Manchester location are important for treatment of which cancer –	Cervix	Vagina	Ovary	Uterus	0
182	Most common lung cancer associated with ectopic ACTH is	Small cell cancer	Carcinoid	Squamous cell carcinoma	Adenocarcinoma	1
183	Which is the most common oncogene involved in human cancer?	RET	RAS	RB	pS3	1
184	The treatment of choice for squamous cell anal cancer?	Laser fulgaration	Chemoradiotherapy	Abdominoperennial resection	Platinum-based chemotherapy	1
185	National Cancer Awareness day is celebrated on:	7th May	31st May	7th November	31st November	0
186	Marker of small cell cancer of lung is -	Chromogranin	Cytokeratin	Vimentin	Desmin	0
187	An old woman is required to receive 4 cycles of cancer chemotherapy. After her first cycle, she developed chemotherapy-induced thrombocytopenia. Then in the next cycle, it would be appropriate to give this patient :	Darbepoetin alpha	Filgrastim (G-CSF)	Iron dextran	Oprelvekin (IL-11)	3
188	In a post menopausal woman with ER positive breast cancer most appropriate drug would be -	Aromatase inhibitor	Tamoxifen	Herceptin	Flutamide	0
189	Habits and customs are conducive to cancer as evident below except	Kangri cancer in Kashmir due to hot pot in winter	Penile cancer and cervical cancer following circumcision	Penile cancer and cervical cancer following circumcision	Lung cancer due to smoking	1
190	Radiation is most commonly associated with which of following cancer?	Leukemia	Lymphoma	Lung carcinoma	Osteoblastoma	0
191	Which of the following about tobacco and oral cancer are true? i. MC histological type - adenocarcinoma ii. Dose-response relationship iii. Synergistic interaction with alcohol iv. Associated with mutations in p53 gene. No association with smokeless tobacco	i, ii, iii, iv	ii, iii, iv	ii, iii	i, iii, iv,	1
192	In cases of Cancer breast with Her-2 neu amplification when will you do FISH?	HER 2 neu 1 +	HER 2 neu 2+	Irrespective of Her 2 neu	HER 2 neu 3+	1
193	The type of ultraviolet radiation (UV) that is known to induce skin cancer is	UV - A	UV - B	UV - C	UV - D	1
194	A 34-year-old man complains of sudden attacks of dizziness, blurred vision, and excruciating headaches of 4 months in duration. During one of these attacks, his blood pressure was 180/120 mm Hg. The patient's father had been treated for thyroid cancer about 15 years ago. Laboratory studies show normal serum levels of aldosterone, renin, and angiotensin. A 24-hour urinalysis reveals increased metanephrines. Episodic hypertension in this patient is most likely caused by a tumor in which of the following endocrine organs?	Adrenal	Kidney	Parathyroid	Pituitary	0
195	70yrs old patient diagnosed with ovarian cancer. Surgical staging involving inguinal lymph nodes	Stage IIIA	Stage IIIB	Stage IVA	Stage IV B	3
196	A new screening test for the breast cancer is approved. Calculate sensitivity and specificity, based on the findings given below.	Sensitivity 82% Specificity 40%	Sensitivity 80% Specificity 96%	Sensitivity 84% Specificity 76%	Sensitivity 90% Specificity 80%	1
197	Statistically impoant risk factors identified for breast cancer-	Early age at marriage	Females of non vegetarian diet	Those who have not breast fed their children	Smoking	2
198	Drug used for prostate cancer is -	Flutamide	Medroxyprogesterone	Goserelin	All of the above	3
199	True about treatment of follicular cancer:	Metastatic follicular cancer can be detected by I-131	Metastatic follicular cancer can be treated by I-131	Adriamycin and taxol are used as chemotherapeutic agents	All of the above	3

100

Most common cancer in men is

Bladder cancer

Colorectal cancer

Prostate cancer

Oral cancer

2

101

The study of smoking as a cause of lung cancer, 90 cases were taken, 75 were smokers and among 100 controls 40 were smokers. Calculate the odds ratio ?

2

4.5

7.5

10

2

102

The commonest pre-malignant condition of oral cancer is

Leukoplakia

Aphthous ulcer

Lichen planus

Erythro-leukoplakia

0

103

Which Lung Cancer resembles Pneumonia with Air Bronchogram sign?

Squamous Cell Ca

Large Cell CA

Small Cell Ca

Bronchoalveolar CA

3

104

For the following statements, select the most likely type of thyroid cancer.Has the best prognosis of all thyroid malignancies.

anaplastic thyroid cancer

follicular cancer of the thyroid

lymphoma of the thyroid

papillary cancer of the thyroid

3

105

Most common histological subtype of lung cancer associated with pancoast tumor?

Small cell cancer

Squamous cell cancer

Adenocarcinoma

Carcinoid tumor

1

106

Roopa Devi, a 65-year-old female with lymph-node-positive breast cancer was treated with systemic chemotherapy. Four weeks later, she developed frequent urination, suprapubic pain, dysuria, and hematuria. Which of the following could have prevented this patient's condition?

Folinic acid

Mesns

Dexrazoxane

Amifostine

1

107

All are precancerous lesions of oral cavity except

Leukoplakia

Erythroplakia

Diffuse oral submucous fibrosis

Diffuse aphthous ulcers

3

108

A 25-year-old woman has recently moved to a new city. She comes today for her first routine visit and annual physical assessment. She feels well, reports no new symptoms, and her past medical history is negative. Her only medication is the oral contraceptive pill; she is currently in university and drinks on a social basis. She reports smoking in her teens but quit 7 years ago. The physical examination is completely normal. She asks you about screening tests for cancer at her age. Which of the following cancer screening tests are recommended for her age group?

mammography every 5 years

Pap smear at least every 3 years

stool for occult blood

chest x-ray (CXR) every 3 years

1

109

A 50-year-old woman is discovered to have metastatic breast cancer. One week after receiving her first dose of chemotherapy, she develops bacterial pneumonia. Which of the following best explains this patient's susceptibility to bacterial infection?

Depletion of serum complement

Impaired neutrophil respiratory burst

Inhibition of clotting factor activation

Neutropenia

3

110

The use of tamoxifen for breast cancer can cause all of the following adverse effects, except:

Endometrial carcinoma

Carcinoma in contralateral breast

Cataract

2

111

Women with Plummer Vinson develops which cancer ?

Pyriform fossa

Esophagus

Subglottis

Epiglottis

1

112

A 33-year-old woman discovers a lump in her left breast on self-examination. Her mother and sister both had breast cancer. A mammogram demonstrates an ill-defined density in the outer quadrant of the left breast, with microcalcifications. Needle aspiration reveals the presence of malignant, ductal epithelial cells. Genetic screening identifies a mutation in BRCA1. In addition to cell cycle control, BRCA1 protein promotes which of the following cellular functions?

Apoptosis

Cell Adhesion

DNA Repair

Gene Transcription

2

113

Stage lb cervical cancer is diagnosed in a young woman. Assuming that the cancer is confirmed to the cervix and that intraoperative biopsies are negative, which of the following structure would not be removed during the radical hysterectomy?

Uterosacral and uterovesical ligaments

Pelvic nodes

The entire parametrium on both sides of the cervix

Both ovaries

3

114

A 34-year-old man complains of sudden attacks of dizziness, blurred vision, and excruciating headaches of 4 months in duration. During one of these attacks, his blood pressure was 180/120 mm Hg. The patient's father had been treated for thyroid cancer about 15 years ago. Laboratory studies show normal serum levels of aldosterone, renin, and angiotensin. A 24-hour urinalysis reveals increased metanephrines. Episodic hypeension in this patient is most likely caused by a tumor in which of the following endocrine organs?

Adrenal

Kidney

Parathyroid

Pituitary

0

115

In which the following head and neck cancers, is lymph node metastasis least common

Tongue

Buccal mucosa

Hard palate

Lower alveolus

2

116

Cancer cells express Telomerase which is:

RNA-dependent DNA polymerase

DNA-dependent DNA polymerase

RNA-dependent DNA polymerase

3

117

Young's operation of Penile cancer is

Total amputation of penis with Bilateral ilio - inguinal Block dissection

Total amputation of penis with Unilateral ilio - inguinal Block dissection

Partial amputation of penis with Bilateral ilio - inguinal Block dissection

Partial amputation of penis with Unilateral ilio - inguinal Block dissection

2

118

Which of the following statements are True or False? 1. Genetic polymorphisms of the P450 enzyme system, specifically CYP1A1, or chromosome fragility are associated with the development of lung cancer. 2. Cigarette smoking increases the risk of squamous and small cell lung cancer cell types only. 3. Varenicline-nicotinic acetylcholine receptor paial agonist is used for nicotine dependence. 4. Low-dose, noncontrast, thin-slice helical or spiral chest CT has emerged as a possible new tool for lung cancer screening. 5. Extrathoracic metastatic disease is found at autopsy in 20% of patients with squamous carcinoma.

1,2,3 True & 4,5 False

1,3,4 True & 4,5 False

2,4,5 True & 1,3-False

2,5 True & 1,3,4-False

1

119

Most common type of lung cancer is?

Small cell carcinoma

Adenocarcinoma

Squamous cell carcinoma

Large cell carcinoma

1

120

A 50 year old male with positive family history of prostate cancer has come to you for a screening test. The MOST sensitive screening test to pickup prostate cancer is:

DRE

PSA

DRE + PSA

Endorectal Coil MRI with TtW and T2W images

2

121

The most likely cause for suture leak after colon resection and anastomosis for cancer sigmoid is ?

Subclinical malnutrition

Infection of anastomotic site

Mechanical disruption due to colonic pressure and contractility

Ischaemia

3

122

A 65-year-old man dies after a protracted battle with meta- static colon carcinoma. At autopsy, the liver is filled with multiple nodules of cancer, many of which display central necrosis (umbilication). Which of the following best explains the pathogenesis of tumor umbilication in this patient?

Biphasic tumor

Chronic inflammation

Granulomatous inflammation

Ischemia and infarction

3

123

A patient was given radiotherapy for head and neck cancer. After 6 months chemotherapy was staed. The patient presented with the features shown in Figure after sta of chemotherapy. It is likely due to which drug?

Doxorubicin

Cisplatin

Imatinib

Methotrexate

0

124

Lung cancer most commonly associated with smoking ?

Small cell carcinoma

Adenocarcinoma

Squamous cell carcinoma

Large cell carcinoma

2

125

Cancer caused by chronic parasitic infection -

Cholangiocarcinoma

Hepatic cell Ca

Ca GB

Ca pancreas

0

126

Following surgical removal of a firm nodular cancer swelling in the right breast and exploration of the right axilla, on examination the patient was found to have a winged right scapula. Most likely this could have occurred due to injury to the :

Subscapular muscle

Coracoid process of scapula

Long thoracic nerve

Circumflex scapular artery

2

127

A 50-year-old woman who was obese and hypertensive, came with complaints of bleeding and abdomen pain, diagnosed to be endometrial cancer. Which of the following gene is mutated?

P53

PTEN

Beta catenin

CHD4

1

128

BRAF mutation is seen in 60% of cancers of

Malignant melanoma

Basal cell carcinoma

Squamous cell carcinoma

Teratoma

0

129

In a case-control study of a suspected association between breast cancer and the contraceptive pill, all of the following are true statements except-

The control should come from a population that has the same potential for breast cancer as the cases

The control should exclude women known to be taking the pill at the time of the survey

All the controls need to be healthy

The attributable risk of breast cancer resulting from the pill may be directly measured

3

130

A 78-year-old man underwent surgical repair of an abdominal aoic aneurysm. Postoperatively he developed left lower quadrant pain along with urgency to defecate and had frequent episodes of passage of bright red blood per rectum. He has a history of prostate cancer for which he had received radiation therapy several years ago. Colonoscopy findings of the patient are shown below.X ray abdomen was also done. What is the most likely cause of his symptoms?

Radiation proctitis

Clostridium difficile colitis

Ischemic colitis

Acute diveiculitis

2

131

A 55-year-old woman with cancer of the cervix undergoes hysterectomy and is found to have pelvic lymph nodes involved with cancer. She then receives a course of external beam radiation (4500 rads). When the physician counsels her prior to her radiation treatment, she should be told of all the possible complications of radiation enteritis. Which of the following is generally not associated with radiation injury?

Malabsorption

Intussusception

Ulceration

Fistulization

1

132

Inherited cancer syndrome include all except?

Retinoblastom

Neurofibroma

Xeroderma pigmentosa

Familial polyposis coli

1

133

Marker for ovarian cancer is

CA 125

Ca 19 - 19

Ca 15 - 5

Hypercalcemia

0

134

Anti cancer drug causing nephrotoxicity ?

Cyclophosphamide

Busulfan

Cisplatin

Procarbazine

2

135

Anticancer drug with disulfuram like action -

Procarbazine

Nitrosurea

5 FU

Methotrexate

0

136

In a prospective study comprising 10,000 subjects, 6000 subjects were put on beta carotene and 4000 were not. 3 out of the first 6000 developed lung cancer and 2 out of the second 4000 developed lung cancer. What is the interpretation of the above results ?

Beta carotene is protective in lung cancer

Beta carotene and Lung cancer have no relation to each other

The study design is not sufficient to draw any meaningful conclusions

Beta carotene is carcinogenic

1

137

Which of the following test is unable to differentiate between 'in situ' breast cancer and invasive disease:

Core needle biopsy

FNAC

Excisional biopsy

null

1

138

Antifolate cancer drug are -

Methotrexate

Azathioprine

Cycl osporin

Vincristine

0

139

The American Cancer Society recommends annual screening mammography for healthy women older than___________years NOT RELATED-GYN

30

40

50

55

1

140

Roughly what percentage of patient with metastatic epithelial ovarian cancer will be benefited by treatment with an alkylating agent :

Less than 10 percent

25 to 49 percent

50 to 74 percent

75 to 89 percent

2

141

Most common type of cervical cancer

Squamous cell CA

Small cell CA

Adeno CA

Adenoma

0

142

A drug used in estrogen-dependent breast cancer

Clomiphene citrate

Tamoxifen

Estrogen

Adriamycin

1

143

Which of the following drugs is not used for the treatment of cancer

Cyclophosphamide

Cyclosporine

Methotrexate

6-mercaptopurine

1

144

A 54-year old woman complains of hot flashes and night sweats. Her last menstrual period was 2 years ago. She also has migraine headaches and a family history of breast cancer her maternal aunt. What is the appropriate treatment for her?

Hysterectomy

Endometrial biopsy

Medroxyprogesterone acetate

Estrogen cream

2

145

During endoscopic biopsy of a distal esophageal cancer, perforation of the esophagus is suspected when the patient complains of significant new substernal pain. An immediate chest film reveals air in the mediastinum. You would recommend

Placement of a nasogastric tube to the levels of perforations, antibiotics, and close observation

Spit fistula (cervical pharyngostomy) and gastrostomy

Left thoracotomy, pleural patch oversewing of the perforation, and drainage of the mediastinum.

Esophagogastrectomy celiotomy and right thoracotomy

3

146

A patient with cancer developed extreme degree of radiation toxicity. Fuher history revealed that the dose adjustment of a paicular drug was missed during the course of radiotherapy. Which of the following drugs required a dose adjustment during radiotherapy in order to prevent radiation toxicity?

Vincristine

Dactinomycin

Cyclophosphamide

6-Mercaptopurine

1

147

A 35 year old man feels that he is about to die because he is suffering from gastric cancer. All his radiological investigations prove the contrary. Which is the most probable diagnosis?

Somatic symptom disorder

Illness anxiety disorder

Conversion disorder

Delusional disorder

1

148

Anticancer drug causing lung fibrosis is:

Bleomycin

Cisplatin

Fulvestrant

Tamoxifen

0

149

Down's syndrome predisposes to _____cancer –

AML

CML

ALL

All of these

3

150

Which of the following radioisotopes is commonly used as a source for external beam radiotherapy in the treatment of cancer patients –

Strontium–89

Radium–226

Cobalt–59

Cobalt–60

3

151

The mechanism of anticancer action of fluorouracil is:

Cross linking of double stranded DNA and the resulting inhibition of DNA replication and transcription

Cytotoxicity resulting from a metabolite that interferes with the production of dTMP

Irreversible inhibition of dihydrofolic acid reductase

Inhibiting the formation of mitotic spindle

1

152

Anticancer macrolide is

Sirolimus

Cycloserine

Roxythromycin

Azithromycin

0

153

Killing of Thyroid Cancer cells By I-131 is mainly by

Alpha Rays

X rays

Beta Rays

Gamma Rays

2

154

Schistosoma haematobium is most commonly associated with which of the following bladder cancers?

Squamous cell carcinoma

Adenocarcinoma

Small cell carcinoma

Transitional cell carcinoma

0

155

30 yrs female presented with unilateral breast cancer associated with axilary lymph node enlargement. Modified radical mastectomy was done, fuhur traeatment plan will be

Observation and followup

Adriamycin based chemotherapy followed by tamoxifen depending on estrogen\/progesterone receptor status

Adriamycin based chemotherapy only

Tamoxifen only

1

156

Morphologically diagnostic feature of cancer cells -

T Size

T Mitotic activity

T Cytoplasm

T Lysosomes

1

157

In a post operative case of early stage endometrial cancer, radiation is advised in

Stage 1A Grade I

Stage IA Grade II

Stage IA Grade III

All the above

2

158

30 yrs female presented with unilateral breast cancer associated with axilary lymph node enlargement. Modified radical mastectomy was done, fuher treatment plan will be

Observation and followup

Adriamycin based chemotherapy followed by tamoxifen depending on estrogen/progesterone receptor status

Adriamycin based chemotherapy only

Tamoxifen only

1

159

A 26-year-old healthy man comes to your clinic for an annual wellness examination. He does not take any medications. He smokes half pack of cigarettes daily. He tells you that his father died of colon cancer at the age of 45. He also has a 25-year-old cousin who recently had colonoscopy for rectal bleeding was found to have multiple polyps and is scheduled for total colectomy. Your patient wants to know if he can inherit colon cancer and if there is a way to find out if he is at risk. You talk to him about how some cancers can be caused by genetic mutations. For what genetic mutation is this patient at highest risk?

MEN1

RET

APC

MSH

2

160

Most common type of thyroid cancer is:

Papillary carcinoma

Follicular carcinoma

Anaplastic carcinoma

Medullary carcinoma

0

161

In the reconstruction following excision of previously irradiated cheek cancer the flap will be

Local tongue

Cervical

Forehead

Pectoralis major myocutaneous

3

162

A 37-year-old woman is suffering from carcinoma of the uterus(fundus area) . Cancer cells are likely to metastasize directly to which of the following lymph nodes?,

External iliac nodes

Internal iliac nodes

Superficial inguinal nodes

Aoic (lumbar) nodes

2

163

A 54 year old man presents to a physician with headaches. A complete blood count demonstrates a hematocrit of 62%. The peripheral smear showed normocellular erythrocytes, with increased reticulocytes and nucleated red cells. Bone marrow biopsy demonstrates increased numbers of erythrocytic precursors. Cancer of which of the following organs would be most likely to cause these findings?

Colon

Kidney

Ovary

Prostate

1

164

Which of the following Human papilloma virus subtypes are not covered by Quadrivalent Anti-cervical cancer vaccine?

Type 6

Type 7

Type 11

Type 16

1

165

Drug useful in breast cancer is ?

Tamoxifen

Cyproterone

Testosterone

Chlorambucil

0

166

An old woman is required to receive 4 cycles of cancer chemotherapy. After her first cycle, she developed chemotherapy induced thrombocytopenia. Then in the next cycle, it would be appropriate to give this patient:

Darbopoietin alpha

Filgrastim (G-CSF)

Iron dextran

Oprelvekin (IL-11)

3

167

A tableau was held in a village to educate the villagers about early detection of oral cancer. This type of health education is called:

Symposium

Seminar

Role play

Learning by doing

2

168

Which of the following is not a premalignant condition oral cancer?

Leukoplakia

Erythroplakia

Oral submucous fibrosis

Systemic Sclerosis

3

169

All of the following anticancer drugs are Cell cycle NON-specific EXCEPT: - March 2013

Doxorubacin

Vincristine

Mitomycin-C

Cyclophosphamide

1

170

Most common cancer of anus:

Adenocarcinoma

Squamous cell CA

Basal cell CA

Melanoma

1

171

Which of the following is not a premalignant condition oral cancer-

Leukoplakia

Erythroplakia

Oral submucous fibrosis

Systemic Sclerosis

3

172

Commonest cancer in burn scar is

Squamous cell carcinoma

Fibrosarcoma

Adenocarcinoma

Adenosquamous carcinoma

0

173

Breast cancer mainly spreads to the veebrae

Aerial route

Direct Invasion

Batsons venous plexus

Via Axillary lymph nodes

2

174

This type of endometrial hyperplasia leads to increased risk of endometrial cancer:

Simple

Proliferative

Atypical

Secretive

2

175

Early gastric cancer generally indicates :

Gastric adencarcinoma detected early

Gastric adenocarcinoma confined to the mucosa

Gastric adenocarcinoma confined to the mucosa & submucosa

Gastric adenocarcinoma less than 1 cm. In size

2

176

Radiation is most commonly associated with which of the following cancer ?

Leukemia

Lymphoma

Lung carcinoma

Osteoblastoma

0

177

White lesion with definite precancerous potential

Leukoplakia

Discoid lupus Erythematosus

Lichen Planus

All of the above

0

178

Mammography was performed in 45 year old female for screening of breast cancer. The finding is suggestive of

Benign lesion

Malignant lesion

Indeterminate

No opinion can be given

1

179

Most commonly associated human papilloma virus with Cancer Cervix is?

HPV 16

HPV 24

HPV 32

HPV 36

0

180

Most common bladder cancer -

SCC

Transitional cell carcinoma

Sarcoma

Lymphoma

1

181

Point A and point B Manchester location are important for treatment of which cancer –

Cervix

Vagina

Ovary

Uterus

0

182

Most common lung cancer associated with ectopic ACTH is

Small cell cancer

Carcinoid

Squamous cell carcinoma

Adenocarcinoma

1

183

Which is the most common oncogene involved in human cancer?

RET

RAS

RB

pS3

1

184

The treatment of choice for squamous cell anal cancer?

Laser fulgaration

Chemoradiotherapy

Abdominoperennial resection

Platinum-based chemotherapy

1

185

National Cancer Awareness day is celebrated on:

7th May

31st May

7th November

31st November

0

186

Marker of small cell cancer of lung is -

Chromogranin

Cytokeratin

Vimentin

Desmin

0

187

An old woman is required to receive 4 cycles of cancer chemotherapy. After her first cycle, she developed chemotherapy-induced thrombocytopenia. Then in the next cycle, it would be appropriate to give this patient :

Darbepoetin alpha

Filgrastim (G-CSF)

Iron dextran

Oprelvekin (IL-11)

3

188

In a post menopausal woman with ER positive breast cancer most appropriate drug would be -

Aromatase inhibitor

Tamoxifen

Herceptin

Flutamide

0

189

Habits and customs are conducive to cancer as evident below except

Kangri cancer in Kashmir due to hot pot in winter

Penile cancer and cervical cancer following circumcision

Lung cancer due to smoking

1

190

Radiation is most commonly associated with which of following cancer?

Leukemia

Lymphoma

Lung carcinoma

Osteoblastoma

0

191

Which of the following about tobacco and oral cancer are true? i. MC histological type - adenocarcinoma ii. Dose-response relationship iii. Synergistic interaction with alcohol iv. Associated with mutations in p53 gene. No association with smokeless tobacco

i, ii, iii, iv

ii, iii, iv

ii, iii

i, iii, iv,

1

192

In cases of Cancer breast with Her-2 neu amplification when will you do FISH?

HER 2 neu 1 +

HER 2 neu 2+

Irrespective of Her 2 neu

HER 2 neu 3+

1

193

The type of ultraviolet radiation (UV) that is known to induce skin cancer is

UV - A

UV - B

UV - C

UV - D

1

194

A 34-year-old man complains of sudden attacks of dizziness, blurred vision, and excruciating headaches of 4 months in duration. During one of these attacks, his blood pressure was 180/120 mm Hg. The patient's father had been treated for thyroid cancer about 15 years ago. Laboratory studies show normal serum levels of aldosterone, renin, and angiotensin. A 24-hour urinalysis reveals increased metanephrines. Episodic hypertension in this patient is most likely caused by a tumor in which of the following endocrine organs?

Adrenal

Kidney

Parathyroid

Pituitary

0

195

70yrs old patient diagnosed with ovarian cancer. Surgical staging involving inguinal lymph nodes

Stage IIIA

Stage IIIB

Stage IVA

Stage IV B

3

196

A new screening test for the breast cancer is approved. Calculate sensitivity and specificity, based on the findings given below.

Sensitivity 82% Specificity 40%

Sensitivity 80% Specificity 96%

Sensitivity 84% Specificity 76%

Sensitivity 90% Specificity 80%

1

197

Statistically impoant risk factors identified for breast cancer-

Early age at marriage

Females of non vegetarian diet

Those who have not breast fed their children

Smoking

2

198

Drug used for prostate cancer is -

Flutamide

Medroxyprogesterone

Goserelin

All of the above

3

199

True about treatment of follicular cancer:

Metastatic follicular cancer can be detected by I-131

Metastatic follicular cancer can be treated by I-131

Adriamycin and taxol are used as chemotherapeutic agents

All of the above

3