sayyid14/MedMCQACancer · Datasets at Hugging Face

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400	A study found that an inverse relation exists between consumption of vegetables containing beta-carotene and development of cancer. This finding could also be because of other factors like fibers, which are also consumed by people along with the vegetables and which also prevents the development of cancer. This is an example of:	Multifactorial association	Differential misclassification	Confounding factor	Common association	2
401	A 59-year-old man is diagnosed with prostate cancer following a digital rectal examination. For the resection of prostate cancer, it is impoant to know that the prostatic ducts open into or on which of the following structures:	Membranous pa of the urethra	Seminal colliculus	Spongy urethra	Prostatic sinus	3
402	Which group of anticancer drugs temozolomide belong to:	Oral alkylating agent	Antitumor Antibiotic	Antimetabolite	Mitotic Spindle Inhibitor	0
403	In which variety of lung cancer cranial irradiation is also given in treatment?	Squamous cell carcinoma	Small cell cancer	Non small cell cancer	Ademocarcinoma	1
404	All of the following drugs are components of the MOPP cancer Chemotherapy regimen EXCEPT:	Procarbazine	Vincristine	Mechlorethamine	Methotrexate	3
405	A 58 year old woman has been diagnosed with locally advanced breast cancer and has been recommended for chemotherapy. She has five years history of myocardial infarction and congestive hea failure. Which antinoeplastic drug should be best avoided -	Anthracycline	Alkylating agent	Platinum compound	Bisphosphonates	0
406	Most unorable/poor prognosis is seen in which type of breast cancer: September 2007	Tubular carcinoma	Medullary carcinoma	Colloid carcinoma	Inflammatory carcinoma	3
407	True about genetics of cancer -	Topoisomerase II is useful for breaking double stranded DNA	Increased telomerase activity enhances anti tumour effect	Maximum synthesis of DNA occurs during G2 phase	Transition from G2 to M phase is important in blockage of cancer spread	0
408	Increased susceptibility to breast cancer is likely to be associated with a mutation in the following gene-	P53	BRCA-1	Retinoblastoma(Rb)	H-Ras	0
409	A 88 year-old woman from Mexico is admitted to the hospital following a bout of severe vomiting and generalized weakness. Initial laboratory values reveal elevated Cat levels. The referring physician tells you that she has breast cancer and her bone scan indicates metastasis to bone. The most likely cause of hypercalcemia is:	Increased PTH production	Increased responsiveness of the PTH receptor 1	Increased PTHrP production	Decreased responsiveness to calcitonin	2
410	In a population of 10,000, beta carotene was given to 6000 people. The remainder did not receive any carotene. 3 out of the first group later suffered from lung cancer while 2 out of the secornd group (non-recepients) also got lung cancer. What is your reasonable conclusion?	Beta carotene and lung cancer have no relation to each other	The p value is not significant	The study is not designed properly	Beta carotene is associated with lung cancer	0
411	Which one of the following enzyme is used as an anti-cancer drug	Alpha-1-antitrypsin	Streptokinase	Asparginase	Papain	2
412	In which of the following perineural invasion in head and neck cancer most commonly seen.	Adenocarcinoma	Adenoid cystic Ca	Basal cell Ca	Squamous Cell Ca	1
413	Which of the following is the investigation of choice for assessment of depth of penetration and perirectal nodes in rectal cancer	Trans rectal ultrasound	CT Scan pelvis	MRI Scan	Double contrast Barium enema	2
414	A patient was given anti- cancer therapy and developed neutropenia which of the following drug can be used to prevent neutropenia in next cycle of chemotherapy?	Filgrastim	Prednisolone	Vitamin B12	Folic Acid	0
415	Which of the following is the most effective intravesical therapy for superficial bladder cancer	Epirubicin	Mitomycin C	Thiotepa	BCG	3
416	In which of the following is medullary thyroid cancer is the most aggressive form -	MEN type I	MEN type II a	MEN type II b	Sporadic cases	2
417	Which of the following strategy has been recommended to reduce the heredity risk for ovarian cancer in women with BRCA -1 and BRCA-2 mutations :	Use of oral contraceptive pills	Screening with transvaginal ultrasound	Sreening with CA -125	Prophylactic oophorectomy	3
418	The most common paraneoplastic syndrome associated with lung cancer?	SIADH	Cushings syndrome	Hypercalcemia	Polycythemia	2
419	According to AJCC 8th edition, staging of 2 cm size Pancreatic cancer if it involves portal vein is?	T1	T2	T3	T4	0
420	Which of the following is precancerous lesion	Pachydermia of larynx	Scleroma larynx	Laryngitis sicca	Keratosis of larynx	3
421	Hydroxyurea mechanism of action in cancer is by inhibiting the enzyme ?	Ribonucleotide diphosphate reductase	Ribonucleotide oxidase	DNA lyase	DNA synthetase	0
422	The mechanism of anti cancer action of fluoruracil is	Cross linking of double standard DNA and the resulting inhibition of DNA replication and transcription	Cytotoxicity resulting from metabolite that interferes with the production of dTMP	Irreversible inhibition of dihydrofolic acid reductase	Selective action of DNA polymerase	2
423	Which of the following Human papilloma virus subtypes are not covered by Quadrivalent Anti- cervical cancer vaccine?	Type 6	Type 7	Type 11	Type 16	1
424	Leucovorin is used for side effect reduction in which anticancer drug?	Methotrexate	5-FU	Adriamycin	Cisplatin	0
425	Urinary bladder cancer is caused by which species of schistosome -	S. hematobium	S. mansoni	S. japonicum	All of the above	0
426	30 yrs female presented with unilateral breast cancer associated with axilary lymph node enlargement. Modified radical mastectomy was done, further treatment plan will be	Observation and follow-up	Adriamycin based chemotherapy followed by tamoxifen depending on estrogen/progesterone receptor status	Adriamycin based chemotherapy only	Tamoxifen only	1
427	Most common lung cancer in non-smokers is:September 2010	Adenocarcinoma	Squamous cell carcinoma	Oat cell carcinoma	None of the above	0
428	Not a carcinogenic for cancer of Head & Neck -	Alcohol	Smoking	Tobacco	Unflourinated water	3
429	When assessing a patient’s needs for psychologic support after the patient has been diagnosed with stage I cancer of the colon, which question by the nurse will provide the most information?	“Can you tell me what has been helpful to you in the past when coping with stressful events?”	“How long ago were you diagnosed with this cancer?”	“Are you familiar with the stages of emotional adjustment to a diagnosis like cancer of the colon?”	“How do you feel about having a possibly terminal illness?”	0
430	Which of the following does not alter the &;T&; stage in breast cancer?	Peaud's orange	Skin ulceration	Pectoral muscle involvement	Serratus anterior muscle muscle involvement	2
431	Which cancer is caused by Schistosoma hematobium-	Colorectal cancer	Bile duct carcinoma	Pancreatic cancer	Urinary bladder cancer	3
432	A 52-year-old man presents with a chronic cough and shortness of breath. He admits to smoking two packs of cigarettes a day for 30 years. Pulmonary function tests reveal chronic obstructive pulmonary disease. In counseling this patient, you advise him to stop smoking immediately You also mention that, in addition to emphysema, which of the following organs carries a significantly increased risk of smoking-related cancer?	Brain	Liver	Pancreas	Skin	2
433	All are true about renal cell cancer except	Invades renal vein	Hematuria may occur	Arises from proximal convoluted tubule	More common in females	3
434	All are precancerous for carcinoma bladder except -a) Tuberculosis bladderb) Aniline dyesc) Schistosomiasisd) Chronic ulcer	b	ad	ac	ab	1
435	Most common primary for metastatic colorectal cancer is ?	Squeamous cell carcinoma of lung	Hepatocellular cancer	Adenocarcinoma of lung	Renal cell cancer	1
436	Which will develop into lung cancer:	Asbestosis	Silicosis	Byssinosis	Benzene exposure	0
437	Child with kidney transplant developed lympho-proliferative cancer. This is due to which viral infection -	CMV	Varicella	HPV	EBV	3
438	Early warning signs of Cancer that public should be aware of include all except	Persistent cough	Lump or hard area in breast	Unexplained weight gain	Change in Wa/mole	2
439	Patient came to eye OPD with recurrent chalazion. Which of the following type of cancer to be excluded in these patients	Basal cell carcinoma	Sebaceous cell carcinoma	Malignant melanoma	Squamous cell carcinoma	1
440	33 year old female patient presents with irregular vaginal bleeding. On examination, papillary lesion is seen on cervix. Further biopsy and staging reveals stage IB1 cervical cancer. She is nulliparous and desires fertility. What would you recommend	Cervical conization alone.	Radical trachelectomy and pelvic lymph node dissection.	Cervical conization and pelvic lymph node dissection.	Radical trachelectomy alone.	1
441	While advancing there is increased chance of developing cancers. Tumorigenesis in aging is due to:	Telomerase reactivation	Telomerase inactivation	Increased apoptosis	Suppression of proto-oncogenes	0
442	The most common cancer, affecting both male and females of the world, is:	Cancer of the pancreas	Buccal mucosa cancer	Lung cancer	Colo-rectal cancer	2
443	If Hemoccult test is negative for screening of colonic cancer, no fuher test is done. If the hemoccult test is positive the individual will have a second stool sample tested with Hemoccult II test. If this second sample is positive for blood, the individual will be referred for more extensive evaluation. The effect of net sensitivity and net specificity of this method of screening is	Net sensitivity and net specificity are both increased	Net sensitivity is decreased and net specificity is increased	Net sensitivity is increased and net specificity is decreased	Net sensitivity remains the same and net specificity is increased	1
444	Which of the following is most sensitive to radiation induced cancer?	Skin	Thyroid	Nerve	Female breast	3
445	Xeroradiography is used in... cancer detection.	Stomach	Breast	Colonic	Pancreatic	1
446	Sentinel lymph node biopsy is useful for the following cancer-	Cervix	Vulva	Vagina	Endometrial	1
447	Screening of cervical cancer at PHC levels is by:	History	Coloposcopy	Pap smear	CT Scan	2
448	A 74-year-old man with a history of smoking notices blood in his chronic daily sputum production. He has no fever or chills, but has lost 10 lb in the past 6 months. On examination, he has bilateral expiratory wheezes, and his fingers are clubbed. There are no lymph nodes and the remaining examination is normal. CXR reveals a left hilar mass. Which of the following suggests that the tumor is a small cell lung cancer?	syndrome of inappropriate antidiuretic hormone (SIADH) secretion	acanthosis nigricans	Cushing's syndrome	leukemoid reaction	0
449	Arrange the incidence of various types of breast cancers in increasing incidence. a. PTEN ( Cowden disease )b. Sporadic breast cancerc. Hereditary breast cancerd. BRCA1e. BRCA2f. Familial breast cancer	a,b,c,d,e,f	a,d,b,c,f,e	c,a,f,d,b,e	a,c,f,e,d,b	3
450	MC cancer due to Radiation –	Leukaemia	Bronchogenic Ca	Thyroid Ca	Breast cancer	0
451	A 65-year-old male is diagnosed as having prostatic cancer based on transrectal biopsy of a 1 cm palpable nodule. Which of the following statement(s) are true concerning his management?	If the tumour is confined within the prostatic capsule, radical prostatectomy is an appropriate option	If positive lymph nodes are detected on laparoscopic pelvic lymph node dissection, radical prostatectomy is indicated	Radical prostatectomy is invariably associated with impotence	There is currently no role for orchidectomy in the management of prostatic cancer	0
452	Hyperglycemia is seen in which of the following lung cancer	SCC	Small cell carcinoma	Adenocarcinoma	Large cell carcinoma	1
453	CAR-T cells are used in the treatment of which of the following cancers?	Acute lymphoblastic leukemia	Soft tissue sarcoma	Medulloblastoma	Small cell lung carcinoma	0
454	Nowadays radium is not used in the Rx of cancer because:	It decays faster and needs frequent replacement	It decays into daughter Radon which is a constant hazard	It has a very long half life	It is a very unstable element	1
455	Which among the following is the most common thyroid cancer?	Papillary	Medullary	Follicular	Anaplatic	0
456	High risk breast cancer female investigation of choice is ?	MRI	USG	Mammography	Clinical examination	0
457	Which cancer is predisposed by radon exposure?	Lung	Cervix	Oral cavity	Bladder	0
458	Roopmati, A 56-year-old female with lymph-node-positive breast cancer was treated with systemic chemotherapy. Four weeks later, she developed frequent urination, suprapubic pain, dysuria, and hematuria. Which of the following could have prevented this patient's condition?	Folinic acid	Mesna	Dexrazoxane	Amifostine	1
459	The BRCA-1 gene associated with breast cancer and ovarian cancer, is located on:	17q	17 p	22q	18q	0
460	Oral contraceptive pills give protection against which of the following cancer ?	Hepatic	Ovary	Cervix	Breast	1
461	The association between oral cancer and tobacco chewing was found to be as follows	0.65	0.8	1.3	2.25	3
462	90% of bladder cancer arise from ?	Squamous cells	Glandular cells	Transitional cells	Smooth muscle cells	2
463	Undescended testis increases the risk of which cancer	Teratoma	Seminoma	Yolk sac tumor	Lymphoma	1
464	Which of the following drugs is useful for treatment of advanced prostrate cancer	Hydroxyurea	Cisplatin	Paclitaxel	Carboplatin	0
465	Which enzymatic mutation is responsible for immortality of cancer cells :	DNA reverse transciptase	RNA polymerase	Telomerase	DNA polymerase	2
466	Smoking may be associated with all of the following cancers, except	Ca Larynx	Ca Nasopharynx	Ca Bladder	null	3
467	Marker of small cell cancer of lung is	Chromogranin	Cytokeratin	Dermin	Vimentin	0
468	A 58-year-old postmenopausal woman is diagnosed with carcinoma of the distal gastrointestinal tract. During surgery lymph nodes from the sacral, internal iliac, and inguinal lymph node groups were removed and sent for histopathologic examination. The pathology report revealed positive cancerous cells only at the inguinal lymph nodes. Which of the following parts of the gastrointestinal tract were most likely affected?	Cutaneous portion of anal canal	Distal rectum	Mucosal zone of anal canal	Pectinate line of anal canal	0
469	Origin of cancer cells in Krukenberg tumour is from:March 2013	Ovarian carcinoma	Gastric carcinoma	Duodenal carcinoma	Pancreatic carcinoma	1
470	Highly aggressive and lethal thyroid cancer:	Papillary	Follicular	Medullary	Anaplastic	3
471	In a village of 1 lakh population, among 2,000 exposed to smoking, 20 developed lung cancer and among 8,000 unexposed people, 8 developed lung cancer. What is attributable risk -	10%	50%	90%	100%	2
472	Which of the following drugs is used as an immunosuppressant but lacks anticancer activity?	Methotrexate	6-Mercaptopurine	Azathioprine	5-Fluorouracil	2
473	Triple assessment for cancer of breast includes which of the following?	History, Clinical examination and mammogram	History, Clinical examination and FNAC	USG, Mammogram and FNAC	Clinical Examination, Mammogram and FNAC	3
474	First symptom invulval cancer is-	Pain	Pruritis	Ulcer	Blood discharge	1
475	In screening of oral cancer not true about exfoliative cytology is?	Keratin interrupts cell collection	It is not very good diagnostic toot	Greater numbers of cells are not superficial	Cells include trans-epithelial cells	3
476	All of the following anticancer agents cause bone marrow suppression except	Chlorambucil	Danorubicin	Doxorubicin	Flutamide	3
477	Which of the following is most common cancer leading to death?	Lung cancer	Oral cancer	Skin cancer	Prostate cancer	0
478	Anticancer drug that causes lung fibrosis is :	Bleomycin	Cisplatin	Fulvestrant	Tamoxifen	0
479	Management of stage II endometrial cancer is	TAH + BSO	Unilateral salpingo oophorectomy + TAH	Modified radical hysterectomy	Chemotherapy only	2
480	Most common lung cancer seen in patients of asbestose related lung disease?	Adenocarcinoma of lung	Mesothelioma	Large cell cancer	Small cell cancer	0
481	Which of the following is inappropriate indication for concomitant chemotherapy in case of head and neck cancer?	Primary treatment for patient with unresectable disease	As an organ safeguarding method of t/t	Postoperative case of intermediate stage resectable tumour	Metastatic advanced head and neck cancer	3
482	The usual dose of radiation delivered to point A in cervical cancer management is	2000 to 4000	4000 to 6000	7000 to 8000	8000 to 10000	2
483	Which of the following anticancer drug causes nephrotoxicity as an adverse effect?	Imatinib	Irinotecan	Bleomycin	Cisplatin	3
484	Paraneoplastic syndrome not seen in renal cell cancer is?	Acanthosis nigricans	Amyloidosis	Polycythemia	Hypeention	0
485	The most likely cause for suture leak after colon resection and anastomosis for cancer sigmoid is -	Subclinical malnutrition	Infection of anastomotic site	Mechanical disruption due to colonic pressure and contractility	Ischaemia	3
486	How much is the risk of ovarian cancer increased above normal in a woman with non autosomal dominant genotype with one first degree relative with ovarian cancer :	2 - 3 times	5 times	10 times	20 times	0
487	People with high risk for development of breast cancer should be treated by prophylactic administration of :	Tamoxifen	Aminoglutethimide	Diethylstilbestrol	Flutamide	0
488	A 50-year-old patient has recently undergone a mastectomy for a 2.5 cm multicentric breast cancer with three positive axillary lymph nodes (stage IIB). A metastatic survey is done, and is negative, and she receives adjuvant chemotherapy. The most common site for distant metastasis would be:	Brain	Bone	Lung	Gastrointestinal tract	1
489	MC cancer due to Radiation:	Leukaemia	Bronchogenic Ca	Thyroid Ca	Breast cancer	0
490	A 50-year-old woman has a lumpectomy following mammographic discovery of a carcinoma of the breast. Which of the following is a well-known characteristic or association of breast cancer?	Low-fat diet	Positive family history	Excessive thinness	Multiparity	1
491	Cancer not associated with BRCA 2 mutation?	Ovarian	Prostate	Bile duct	Liposarcoma	3
492	Predisposing factor for Breast cancer are all EXCEPT: March 2013	Abscess	Positive family history	Nulliparity	High socio-economic status	0
493	Cancer that arises from C-cells of thyroid	Follicular	anaplastic	Papillary	Medullary	3
494	In radiation therapy, it is desirable to use linear accelerators in treating cancers. Which rays are produced by linear accelerators?	X rays	Beta rays	Gamma rays	Neutrons	0
495	Contraceptive method that can prevent cancer cervix-	Condom	OCP	Mini Pills	Tubectomy	0
496	Cancer cells derive its nutrition from	a) Glycolysis	b) Oxidative phosphorylation	c) Increase in mitochondria	d) TCA	0
497	Hormonal therapy used in breast cancer are: a) Danazol b) Cyproterone acetate c) Tamoxifen d) LHRH analogue e) Methotrexate	ab	ae	ad	cd	3
498	Ifosfamide belongs to which group of anticancer drugs-	Alkylating agents	Antiimetobolites	Mitotic inhibitors	Topoisomerase inhibitors	0
499	What is the investigation of choice for the diagnosis of colon cancer?	Barium enema	Colonoscopy + biopsy	USG	CT scan	1

400

A study found that an inverse relation exists between consumption of vegetables containing beta-carotene and development of cancer. This finding could also be because of other factors like fibers, which are also consumed by people along with the vegetables and which also prevents the development of cancer. This is an example of:

Multifactorial association

Differential misclassification

Confounding factor

Common association

2

401

A 59-year-old man is diagnosed with prostate cancer following a digital rectal examination. For the resection of prostate cancer, it is impoant to know that the prostatic ducts open into or on which of the following structures:

Membranous pa of the urethra

Seminal colliculus

Spongy urethra

Prostatic sinus

3

402

Which group of anticancer drugs temozolomide belong to:

Oral alkylating agent

Antitumor Antibiotic

Antimetabolite

Mitotic Spindle Inhibitor

0

403

In which variety of lung cancer cranial irradiation is also given in treatment?

Squamous cell carcinoma

Small cell cancer

Non small cell cancer

Ademocarcinoma

1

404

All of the following drugs are components of the MOPP cancer Chemotherapy regimen EXCEPT:

Procarbazine

Vincristine

Mechlorethamine

Methotrexate

3

405

A 58 year old woman has been diagnosed with locally advanced breast cancer and has been recommended for chemotherapy. She has five years history of myocardial infarction and congestive hea failure. Which antinoeplastic drug should be best avoided -

Anthracycline

Alkylating agent

Platinum compound

Bisphosphonates

0

406

Most unorable/poor prognosis is seen in which type of breast cancer: September 2007

Tubular carcinoma

Medullary carcinoma

Colloid carcinoma

Inflammatory carcinoma

3

407

True about genetics of cancer -

Topoisomerase II is useful for breaking double stranded DNA

Increased telomerase activity enhances anti tumour effect

Maximum synthesis of DNA occurs during G2 phase

Transition from G2 to M phase is important in blockage of cancer spread

0

408

Increased susceptibility to breast cancer is likely to be associated with a mutation in the following gene-

P53

BRCA-1

Retinoblastoma(Rb)

H-Ras

0

409

A 88 year-old woman from Mexico is admitted to the hospital following a bout of severe vomiting and generalized weakness. Initial laboratory values reveal elevated Cat levels. The referring physician tells you that she has breast cancer and her bone scan indicates metastasis to bone. The most likely cause of hypercalcemia is:

Increased PTH production

Increased responsiveness of the PTH receptor 1

Increased PTHrP production

Decreased responsiveness to calcitonin

2

410

In a population of 10,000, beta carotene was given to 6000 people. The remainder did not receive any carotene. 3 out of the first group later suffered from lung cancer while 2 out of the secornd group (non-recepients) also got lung cancer. What is your reasonable conclusion?

Beta carotene and lung cancer have no relation to each other

The p value is not significant

The study is not designed properly

Beta carotene is associated with lung cancer

0

411

Which one of the following enzyme is used as an anti-cancer drug

Alpha-1-antitrypsin

Streptokinase

Asparginase

Papain

2

412

In which of the following perineural invasion in head and neck cancer most commonly seen.

Adenocarcinoma

Adenoid cystic Ca

Basal cell Ca

Squamous Cell Ca

1

413

Which of the following is the investigation of choice for assessment of depth of penetration and perirectal nodes in rectal cancer

Trans rectal ultrasound

CT Scan pelvis

MRI Scan

Double contrast Barium enema

2

414

A patient was given anti- cancer therapy and developed neutropenia which of the following drug can be used to prevent neutropenia in next cycle of chemotherapy?

Filgrastim

Prednisolone

Vitamin B12

Folic Acid

0

415

Which of the following is the most effective intravesical therapy for superficial bladder cancer

Epirubicin

Mitomycin C

Thiotepa

BCG

3

416

In which of the following is medullary thyroid cancer is the most aggressive form -

MEN type I

MEN type II a

MEN type II b

Sporadic cases

2

417

Which of the following strategy has been recommended to reduce the heredity risk for ovarian cancer in women with BRCA -1 and BRCA-2 mutations :

Use of oral contraceptive pills

Screening with transvaginal ultrasound

Sreening with CA -125

Prophylactic oophorectomy

3

418

The most common paraneoplastic syndrome associated with lung cancer?

SIADH

Cushings syndrome

Hypercalcemia

Polycythemia

2

419

According to AJCC 8th edition, staging of 2 cm size Pancreatic cancer if it involves portal vein is?

T1

T2

T3

T4

0

420

Which of the following is precancerous lesion

Pachydermia of larynx

Scleroma larynx

Laryngitis sicca

Keratosis of larynx

3

421

Hydroxyurea mechanism of action in cancer is by inhibiting the enzyme ?

Ribonucleotide diphosphate reductase

Ribonucleotide oxidase

DNA lyase

DNA synthetase

0

422

The mechanism of anti cancer action of fluoruracil is

Cross linking of double standard DNA and the resulting inhibition of DNA replication and transcription

Cytotoxicity resulting from metabolite that interferes with the production of dTMP

Irreversible inhibition of dihydrofolic acid reductase

Selective action of DNA polymerase

2

423

Which of the following Human papilloma virus subtypes are not covered by Quadrivalent Anti- cervical cancer vaccine?

Type 6

Type 7

Type 11

Type 16

1

424

Leucovorin is used for side effect reduction in which anticancer drug?

Methotrexate

5-FU

Adriamycin

Cisplatin

0

425

Urinary bladder cancer is caused by which species of schistosome -

S. hematobium

S. mansoni

S. japonicum

All of the above

0

426

30 yrs female presented with unilateral breast cancer associated with axilary lymph node enlargement. Modified radical mastectomy was done, further treatment plan will be

Observation and follow-up

Adriamycin based chemotherapy followed by tamoxifen depending on estrogen/progesterone receptor status

Adriamycin based chemotherapy only

Tamoxifen only

1

427

Most common lung cancer in non-smokers is:September 2010

Adenocarcinoma

Squamous cell carcinoma

Oat cell carcinoma

None of the above

0

428

Not a carcinogenic for cancer of Head & Neck -

Alcohol

Smoking

Tobacco

Unflourinated water

3

429

When assessing a patient’s needs for psychologic support after the patient has been diagnosed with stage I cancer of the colon, which question by the nurse will provide the most information?

“Can you tell me what has been helpful to you in the past when coping with stressful events?”

“How long ago were you diagnosed with this cancer?”

“Are you familiar with the stages of emotional adjustment to a diagnosis like cancer of the colon?”

“How do you feel about having a possibly terminal illness?”

0

430

Which of the following does not alter the &;T&; stage in breast cancer?

Peaud's orange

Skin ulceration

Pectoral muscle involvement

Serratus anterior muscle muscle involvement

2

431

Which cancer is caused by Schistosoma hematobium-

Colorectal cancer

Bile duct carcinoma

Pancreatic cancer

Urinary bladder cancer

3

432

A 52-year-old man presents with a chronic cough and shortness of breath. He admits to smoking two packs of cigarettes a day for 30 years. Pulmonary function tests reveal chronic obstructive pulmonary disease. In counseling this patient, you advise him to stop smoking immediately You also mention that, in addition to emphysema, which of the following organs carries a significantly increased risk of smoking-related cancer?

Brain

Liver

Pancreas

Skin

2

433

All are true about renal cell cancer except

Invades renal vein

Hematuria may occur

Arises from proximal convoluted tubule

More common in females

3

434

All are precancerous for carcinoma bladder except -a) Tuberculosis bladderb) Aniline dyesc) Schistosomiasisd) Chronic ulcer

b

ad

ac

ab

1

435

Most common primary for metastatic colorectal cancer is ?

Squeamous cell carcinoma of lung

Hepatocellular cancer

Adenocarcinoma of lung

Renal cell cancer

1

436

Which will develop into lung cancer:

Asbestosis

Silicosis

Byssinosis

Benzene exposure

0

437

Child with kidney transplant developed lympho-proliferative cancer. This is due to which viral infection -

CMV

Varicella

HPV

EBV

3

438

Early warning signs of Cancer that public should be aware of include all except

Persistent cough

Lump or hard area in breast

Unexplained weight gain

Change in Wa/mole

2

439

Patient came to eye OPD with recurrent chalazion. Which of the following type of cancer to be excluded in these patients

Basal cell carcinoma

Sebaceous cell carcinoma

Malignant melanoma

Squamous cell carcinoma

1

440

33 year old female patient presents with irregular vaginal bleeding. On examination, papillary lesion is seen on cervix. Further biopsy and staging reveals stage IB1 cervical cancer. She is nulliparous and desires fertility. What would you recommend

Cervical conization alone.

Radical trachelectomy and pelvic lymph node dissection.

Cervical conization and pelvic lymph node dissection.

Radical trachelectomy alone.

1

441

While advancing there is increased chance of developing cancers. Tumorigenesis in aging is due to:

Telomerase reactivation

Telomerase inactivation

Increased apoptosis

Suppression of proto-oncogenes

0

442

The most common cancer, affecting both male and females of the world, is:

Cancer of the pancreas

Buccal mucosa cancer

Lung cancer

Colo-rectal cancer

2

443

If Hemoccult test is negative for screening of colonic cancer, no fuher test is done. If the hemoccult test is positive the individual will have a second stool sample tested with Hemoccult II test. If this second sample is positive for blood, the individual will be referred for more extensive evaluation. The effect of net sensitivity and net specificity of this method of screening is

Net sensitivity and net specificity are both increased

Net sensitivity is decreased and net specificity is increased

Net sensitivity is increased and net specificity is decreased

Net sensitivity remains the same and net specificity is increased

1

444

Which of the following is most sensitive to radiation induced cancer?

Skin

Thyroid

Nerve

Female breast

3

445

Xeroradiography is used in... cancer detection.

Stomach

Breast

Colonic

Pancreatic

1

446

Sentinel lymph node biopsy is useful for the following cancer-

Cervix

Vulva

Vagina

Endometrial

1

447

Screening of cervical cancer at PHC levels is by:

History

Coloposcopy

Pap smear

CT Scan

2

448

A 74-year-old man with a history of smoking notices blood in his chronic daily sputum production. He has no fever or chills, but has lost 10 lb in the past 6 months. On examination, he has bilateral expiratory wheezes, and his fingers are clubbed. There are no lymph nodes and the remaining examination is normal. CXR reveals a left hilar mass. Which of the following suggests that the tumor is a small cell lung cancer?

syndrome of inappropriate antidiuretic hormone (SIADH) secretion

acanthosis nigricans

Cushing's syndrome

leukemoid reaction

0

449

Arrange the incidence of various types of breast cancers in increasing incidence. a. PTEN ( Cowden disease )b. Sporadic breast cancerc. Hereditary breast cancerd. BRCA1e. BRCA2f. Familial breast cancer

a,b,c,d,e,f

a,d,b,c,f,e

c,a,f,d,b,e

a,c,f,e,d,b

3

450

MC cancer due to Radiation –

Leukaemia

Bronchogenic Ca

Thyroid Ca

Breast cancer

0

451

A 65-year-old male is diagnosed as having prostatic cancer based on transrectal biopsy of a 1 cm palpable nodule. Which of the following statement(s) are true concerning his management?

If the tumour is confined within the prostatic capsule, radical prostatectomy is an appropriate option

If positive lymph nodes are detected on laparoscopic pelvic lymph node dissection, radical prostatectomy is indicated

Radical prostatectomy is invariably associated with impotence

There is currently no role for orchidectomy in the management of prostatic cancer

0

452

Hyperglycemia is seen in which of the following lung cancer

SCC

Small cell carcinoma

Adenocarcinoma

Large cell carcinoma

1

453

CAR-T cells are used in the treatment of which of the following cancers?

Acute lymphoblastic leukemia

Soft tissue sarcoma

Medulloblastoma

Small cell lung carcinoma

0

454

Nowadays radium is not used in the Rx of cancer because:

It decays faster and needs frequent replacement

It decays into daughter Radon which is a constant hazard

It has a very long half life

It is a very unstable element

1

455

Which among the following is the most common thyroid cancer?

Papillary

Medullary

Follicular

Anaplatic

0

456

High risk breast cancer female investigation of choice is ?

MRI

USG

Mammography

Clinical examination

0

457

Which cancer is predisposed by radon exposure?

Lung

Cervix

Oral cavity

Bladder

0

458

Roopmati, A 56-year-old female with lymph-node-positive breast cancer was treated with systemic chemotherapy. Four weeks later, she developed frequent urination, suprapubic pain, dysuria, and hematuria. Which of the following could have prevented this patient's condition?

Folinic acid

Mesna

Dexrazoxane

Amifostine

1

459

The BRCA-1 gene associated with breast cancer and ovarian cancer, is located on:

17q

17 p

22q

18q

0

460

Oral contraceptive pills give protection against which of the following cancer ?

Hepatic

Ovary

Cervix

Breast

1

461

The association between oral cancer and tobacco chewing was found to be as follows

0.65

0.8

1.3

2.25

3

462

90% of bladder cancer arise from ?

Squamous cells

Glandular cells

Transitional cells

Smooth muscle cells

2

463

Undescended testis increases the risk of which cancer

Teratoma

Seminoma

Yolk sac tumor

Lymphoma

1

464

Which of the following drugs is useful for treatment of advanced prostrate cancer

Hydroxyurea

Cisplatin

Paclitaxel

Carboplatin

0

465

Which enzymatic mutation is responsible for immortality of cancer cells :

DNA reverse transciptase

RNA polymerase

Telomerase

DNA polymerase

2

466

Smoking may be associated with all of the following cancers, except

Ca Larynx

Ca Nasopharynx

Ca Bladder

null

3

467

Marker of small cell cancer of lung is

Chromogranin

Cytokeratin

Dermin

Vimentin

0

468

A 58-year-old postmenopausal woman is diagnosed with carcinoma of the distal gastrointestinal tract. During surgery lymph nodes from the sacral, internal iliac, and inguinal lymph node groups were removed and sent for histopathologic examination. The pathology report revealed positive cancerous cells only at the inguinal lymph nodes. Which of the following parts of the gastrointestinal tract were most likely affected?

Cutaneous portion of anal canal

Distal rectum

Mucosal zone of anal canal

Pectinate line of anal canal

0

469

Origin of cancer cells in Krukenberg tumour is from:March 2013

Ovarian carcinoma

Gastric carcinoma

Duodenal carcinoma

Pancreatic carcinoma

1

470

Highly aggressive and lethal thyroid cancer:

Papillary

Follicular

Medullary

Anaplastic

3

471

In a village of 1 lakh population, among 2,000 exposed to smoking, 20 developed lung cancer and among 8,000 unexposed people, 8 developed lung cancer. What is attributable risk -

10%

50%

90%

100%

2

472

Which of the following drugs is used as an immunosuppressant but lacks anticancer activity?

Methotrexate

6-Mercaptopurine

Azathioprine

5-Fluorouracil

2

473

Triple assessment for cancer of breast includes which of the following?

History, Clinical examination and mammogram

History, Clinical examination and FNAC

USG, Mammogram and FNAC

Clinical Examination, Mammogram and FNAC

3

474

First symptom invulval cancer is-

Pain

Pruritis

Ulcer

Blood discharge

1

475

In screening of oral cancer not true about exfoliative cytology is?

Keratin interrupts cell collection

It is not very good diagnostic toot

Greater numbers of cells are not superficial

Cells include trans-epithelial cells

3

476

All of the following anticancer agents cause bone marrow suppression except

Chlorambucil

Danorubicin

Doxorubicin

Flutamide

3

477

Which of the following is most common cancer leading to death?

Lung cancer

Oral cancer

Skin cancer

Prostate cancer

0

478

Anticancer drug that causes lung fibrosis is :

Bleomycin

Cisplatin

Fulvestrant

Tamoxifen

0

479

Management of stage II endometrial cancer is

TAH + BSO

Unilateral salpingo oophorectomy + TAH

Modified radical hysterectomy

Chemotherapy only

2

480

Most common lung cancer seen in patients of asbestose related lung disease?

Adenocarcinoma of lung

Mesothelioma

Large cell cancer

Small cell cancer

0

481

Which of the following is inappropriate indication for concomitant chemotherapy in case of head and neck cancer?

Primary treatment for patient with unresectable disease

As an organ safeguarding method of t/t

Postoperative case of intermediate stage resectable tumour

Metastatic advanced head and neck cancer

3

482

The usual dose of radiation delivered to point A in cervical cancer management is

2000 to 4000

4000 to 6000

7000 to 8000

8000 to 10000

2

483

Which of the following anticancer drug causes nephrotoxicity as an adverse effect?

Imatinib

Irinotecan

Bleomycin

Cisplatin

3

484

Paraneoplastic syndrome not seen in renal cell cancer is?

Acanthosis nigricans

Amyloidosis

Polycythemia

Hypeention

0

485

The most likely cause for suture leak after colon resection and anastomosis for cancer sigmoid is -

Subclinical malnutrition

Infection of anastomotic site

Mechanical disruption due to colonic pressure and contractility

Ischaemia

3

486

How much is the risk of ovarian cancer increased above normal in a woman with non autosomal dominant genotype with one first degree relative with ovarian cancer :

2 - 3 times

5 times

10 times

20 times

0

487

People with high risk for development of breast cancer should be treated by prophylactic administration of :

Tamoxifen

Aminoglutethimide

Diethylstilbestrol

Flutamide

0

488

A 50-year-old patient has recently undergone a mastectomy for a 2.5 cm multicentric breast cancer with three positive axillary lymph nodes (stage IIB). A metastatic survey is done, and is negative, and she receives adjuvant chemotherapy. The most common site for distant metastasis would be:

Brain

Bone

Lung

Gastrointestinal tract

1

489

MC cancer due to Radiation:

Leukaemia

Bronchogenic Ca

Thyroid Ca

Breast cancer

0

490

A 50-year-old woman has a lumpectomy following mammographic discovery of a carcinoma of the breast. Which of the following is a well-known characteristic or association of breast cancer?

Low-fat diet

Positive family history

Excessive thinness

Multiparity

1

491

Cancer not associated with BRCA 2 mutation?

Ovarian

Prostate

Bile duct

Liposarcoma

3

492

Predisposing factor for Breast cancer are all EXCEPT: March 2013

Abscess

Positive family history

Nulliparity

High socio-economic status

0

493

Cancer that arises from C-cells of thyroid

Follicular

anaplastic

Papillary

Medullary

3

494

In radiation therapy, it is desirable to use linear accelerators in treating cancers. Which rays are produced by linear accelerators?

X rays

Beta rays

Gamma rays

Neutrons

0

495

Contraceptive method that can prevent cancer cervix-

Condom

OCP

Mini Pills

Tubectomy

0

496

Cancer cells derive its nutrition from

a) Glycolysis

b) Oxidative phosphorylation

c) Increase in mitochondria

d) TCA

0

497

Hormonal therapy used in breast cancer are: a) Danazol b) Cyproterone acetate c) Tamoxifen d) LHRH analogue e) Methotrexate

ab

ae

ad

cd

3

498

Ifosfamide belongs to which group of anticancer drugs-

Alkylating agents

Antiimetobolites

Mitotic inhibitors

Topoisomerase inhibitors

0

499

What is the investigation of choice for the diagnosis of colon cancer?

Barium enema

Colonoscopy + biopsy

USG

CT scan

1