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Which of the following is a Radioactive anti-cancer Monoclonal antibody?

Basiliximab

Bevacizumab

Ibritumomab

Rituximab

A 52 year old woman presents to her physician for a check-up. She is recovering from a wrist fracture after a fall. Dual energy x-ray absorptiometry of the hip had shown her to have osteoporosis. She became menopausal at age 50 and did not begin hormone replacement therapy because of a strong family history of breast cancer. She now fears a future hip fracture and would like to begin a bone loss prevention regime.Which of the following pharmaceutical agents is most appropriate for this patient?

Calcitonin nasal spray

Oral conjugated estrogen

Raloxifene

Tamoxifen

All are precancerous lesions of oral cavity except -

Leukoplakia

Erythroplakia

Diffuse oral submucous fibrosis

Diffuse aphthous ulcers

In a hindsight study, the progeny of woman who took diethylstilbestrol had an increased risk for developing which of the following cancers?

Bladder cancer

Endometrial carcinoma

Ovarian carcinoma

Vaginal clear cell adenocarcinoma

Breast cancer is conservatively treated by following methods

It is based on relative size of breast tumor

Radiotherapy is given

Chemotherapy is given

Surgery is best modality of treatment

Non keratinized squamous cancer of nasopharynx belongs to which category?

Type 1

Type 2

Type 3

Type 4

Treatment with herceptin in breast cancer is indicated for

ER receptor +ve tumours

PR receptor +ve tumours

K : 67 stain +ve tumours

Tumours with over-expressed C-erb B-2 protein

Which of the following is the commonest nephropathy seen in a patient with cancer?

Minimal change disease

IgA nephropathy

Membranous nephropathy

Focal segmental glomerulosclerosis

An edentulous 72-year-old man with a 50-year history of cigarette smoking presents with a nontender, hard mass in the lateral neck. The simplest way to establish an accurate histological diagnosis of a neck mass suspected to be cancerous is

Fine needle aspiration cytology

Bone marrow biopsy

Nasopharyngoscopy

CT scan of the head and neck

A research team conducted a nation wide survey of Industries and factories. While arranging the data they observed that the most common occupational cancer was

CA skin

CA bladder

CA lung

Leukemia

Ivor Lewis operation is the treatment of choice for cancer involving _____ esophagus

Middle 1/3rd

Lower 1/3rd

Upper 1/3rd

Entire Esophagus

A 55-year-old patient presents with chronic cough. A chest x-ray film demonstrates a circular lesion near the apex of the lung. CT-guided biopsy of the lesion demonstrates a malignant tumor arising in an area of scarred lung. Which of the following type of cancer is MOST likely to be present?

Adenocarcinoma

Bronchioloalveolar carcinoma

Large cell carcinoma

Oat cell carcinoma

An investigator is studying a new biomarker test to detect breast cancer at early stages. A randomized study is conducted to compare the new test to the current standard of care. mammography, among women over 50 years ol& They conclude that breast cancer patients whose cancer was identified by the biomarker lived on average 1.5 years longer than those whose cancers were identified by mammography. If additional independent studies show that there truly was no difference in survival between the two groups, which of the following biases is most likely to have occurred?

Confounding

Insensitive test

Lead time bias

Measurement error

False about Follicular cancer:

More common in endemic areas, it is more malignant in females

FNAC cannot differentiate adenoma from carcinoma

Not encapsulated

Common at age 50 yrs

In a case-control study of a suspected association between breast cancer and the contraceptive pill, all of the following are true statements except

The control should come from a population that has the same potential for breast cancer as the cases

The control should exclude women known to be taking the pill at the time of the survey

All the controls need to be healthy

The attributing risk of breast cancer resulting from the pill may be directly measured

Most common type of cervical cancer:

Squamous cell CA

Small cell CA

Adeno CA

Adenoma

A 60-year-old man who worked for 30 years in a chemical factory complains of blood in his urine. Urine cytology discloses dysplastic cells. A bladder biopsy demonstrates transitional cell carcinoma. Which of the following carcinogens was most likely involved in the pathogenesis of bladder cancer in this patient?

Aniline dyes

Arsenic

Benzene

Cisplatinum

A 68-year-old man with prostate cancer and bone metastases presents with shaking chills and fever. The peripheral WBC count is 1,000/mL (normal = 4,000 to 11,000/mL). Which of the following terms best describes this hematologic finding?

Leukocytosis

Leukopenia

Neutrophilia

Leukemoid reaction

Poor prognostic factors in the management of cancer cervix are the following except :

Young age

Well-defferentiated squamous cell carcinoma

Hydroureter

Adenocarcinoma

Recent drug for metastatic hormone receptor(+)and HER-2 (-) metastatic breast cancer :

Palbociclib

Ipataseib

Herceptin

Buparlisib

Specific marker for prostatic cancer is -

Alkaline phosphatase

Prostate specific antigen

Acid phosphatase

CA 125

Point A & point B Manchester location are used in radiotherapy treatment of which cancer?

Kidney

Uterus

Cervix

Vagina

Most common cancer world wide -

Lung

Prostate

Liver

Kidneny

Small cell cancer commonly metastasizes to ?

Brain

Liver

Bone

Kidney

Treatment of stage I bladder cancer is

Radical cystectomy

Endoscopic removal with intravesical chemotherapy

Chemotherapy

Radiotherapy

Natural elements having anticancer propeies -

Nitrosoamines

Vit. C

V1L D

Carotene

Neutropenia develops in a patients undergoing cancer chemotherapy. Administration of which one of the following agents would accelerate recovery of neutrophil counts.

Leucovorin

Filgrastim

Prednisone

Vitamin B12

In a village of 1 lakh population, among 2,000 exposed to smoking, 20 developed lung cancer and among 8,000 unexposed people, 8 developed lung cancer. What is attributable risk-

10%

50%

90%

100%

Following surgical removal of a firm nodular cancerous swelling in the right breast and exploration of the right axilla, patient was found to have a winged right scapula. This occurred due to injury to which of the following nerve?

Subscapular muscle

Coracoid process of scapula

Long thoracic nerve

Circumflex scapular aery

In renal cell cancer gene involved in mutation

VHL

TP53

NF1

BRCA-1

The effective and safe drug for intractable pain in terminal cancer stage is :

Injectable pethidine

Injectable ketamine

Oral Brufen

Oral Morphine

Many drugs are used as rescue therapy for preventing the adverse effects of anticancer drugs. Folinic acid is used in:-

Methotrexate toxicity

Cisplatin toxicity

Doxorubicin toxicity

Cyclophosphamide toxicity

Which is the most common cancer which results in death?

Oral cancer

Breast cancer

Prostate cancer

Lung cancer

Most common cancer in children less than 10 years:

Leukemia

Neuroblastoma

Brain tumor

Wilm's tumor

Factors that protect against endometrial cancer

Obesity

Smoking

Nulliparity

Diabetes

Characteristic feature of Cancer fallopian tube :

Watery discharge P/V

Hemorrhage

Pain

Sepsis

A 42-year-old woman with metastatic breast cancer is known to have tumors in the interveebral foramina between the fouh and fifth cervical veebrae and between the fouh and fifth thoracic veebrae. Which of the following spinal nerves may be damaged?,

Fouh cervical and fouh thoracic nerves

Fifth cervical and fifth thoracic nerves

Fouh cervical and fifth thoracic nerves

Fifth cervical and fouh thoracic nerves

Necrolytic Migratory Erythema is a sign of underlying cancer due to involvement of:-

Liver

Kidney

Testis

Pancreas

Which enzymatic mutation is responsible for immoality of cancer cells?

DNA reverse transcriptase

RNA polymerase

Telomerase

DNA polymerase

A 49-year-old man suffering from carcinoma of the prostate was x -rayed. He showed areas of sclerosis and collapse of T10 and T11 veebrae in x-ray. The spread of this cancer to the above veebrae was through -

Sacral canal

Lymphatic vessels

Internal veebral plexus of veins

Superior rectal vein

Metastasis of cancer has its roots in structural abnormalities of

Glycolipids in nervous tissue

Glycoproteins on cell surface

Lipoproteins in blood

None of the above

Total gastrectomy is preferred for which type of gastric cancers

Proximal Cancer

Distal Cancer

Ulcerating cancer in the body

Polypoidal cancer in the antrum

An epidemiologic study of cancer deaths recorded in the last half of the 20th century is conducted. The number of deaths for one particular cancer had increased markedly in developed nations. More than 30% of cancer deaths in men, and more than 24% of cancer deaths in women, were caused by this neoplasm in 1998. In some nations, prevention strategies reduced deaths from this cancer. Which of the following neoplasms was most likely identified by this study?

Cerebral glioma

Bronchogenic carcinoma

Hepatocellular carcinoma

Colonic adenocarcinoma

The most common side effect of cancer chemotherapy is nausea with or without vomiting. The anticancer drugs vary in their ability to cause nausea and vomiting. Which of the following anti-cancer drugs is least likely to cause nausea and vomiting?

Chlorambucil

Cisplatin

Doxorubicin

Daunorubicin

Roopmati A56 year old female with lymph node positive breast with cancer was stated with systemic chemotherapy. 4 weeks letter should develop frequent urination suprapubic pain dysuria and hematuria.which of the following could have prevented this patients condition

Folinic acid

Mesna

Dexrazoxane

Amifostine

Test to differentiate the chromosome of normal and cancer cells:

PCR

Comparative genomic hybridization

Karyotyping

Western Blotting

Lung cancer is an industrial hazard in/for-

Chimney sweepers

Aniline industry

Gas industry

Benzol indusntry

Smoking may be associated with all of the following cancers, except:

Ca Larynx

Ca Nasopharynx

Ca Bladder

A 56-year-old woman has nausea due to chemotherapy for breast cancer. Droperidol is effective in reducing nausea because it blocks wof

5-HT 2 receptors in the CTZ

Glucocoicoid receptors in the vomiting center

Dopamine receptors in the CTZ

ACh receptors in the periphery

Type 1 gastric cancer according to Bormann's classification:

Protruding

Ulcerated

Flat

Excavated

Cancer which most commonly metastasizes to jaw bone is:

Breast

Prostatic

Lung

Kidney

A 62-year-old man presents with dark tarry stools and light-headedness. Upper endoscopy finds an ulcerating lesion in his stomach and biopsies confirm gastric cancer. Which of the following is a risk factor for carcinoma of the stomach?

Helicobacter pylori infection

high socioeconomic status

high protein diet

high alcohol consumption

Risk of breast cancer is highest in

Lobular carcinoma in situ

Proliferative disease without atypia

Proliferative disease with atypia

Atypical ductal hyperplasia

A 67-year-old man with lung cancer notices symptoms of weakness in his arms and legs. He describes difficulty in rising out of chair or going upstairs, but no pain or discomfort. On examination, proximal muscle strength is 4 out of 5 in the upper and lower limbs, but the reflexes, tone, and sensation are normal. He has a colored rash on his eyelids, and raised papules on his knuckles.For the above patient with muscle weakness, select the most likely anatomic site for the disorder.

anterior horn cell

peripheral nerve

neuromuscular junction

muscle

Which cancer has maximum propensity to spread to cervical lymph nodes ?

Nasopharyngal carcinoma

Carcinoma of hard palate

Carcinoma of soft palate

Carcinoma of mandible

Drug of choice for controlling severe pain in cancer patients is:

Morphine

Diclofenac

Ibuprofen

Codiene

A 56-year-old female with lymph-node-positive breast cancer was treated with systemic chemotherapy. Four weeks later, she developed frequent urination, suprapubic pain, dysuria, and hematuria. Which of the following could have prevented this patient's condition?

Folinic acid

Mesna

Dexrazoxane

Amifostine

Chimney sweeper's cancer is also known as

Carcinoma scrotum

Carcinoma colon

Carcinoma lung

Carcinoma penis

Which isotope is used for treating bone cancer?

Sr

Ga

1123

Tc

Screening for oral cancer comes under which level of prevention?

Primary level

Secondary level

Tertiary level

None of the above

Radiation is most commonly associated with the following thyroid cancer?

Papillary

Follicular

Medullary

Anaplastic

Ifosfamide belongs to which Group of anticancer drugs

Alkylating agent

Antimebolites

Mitotic inhibitors

Topoisomerase inhibitors

A 18-year-old girl, sexually active for the past 3 years. Her family history is negative for cancer and cardiac disease. Examination is unremarkable. Which of the following screening tests should this patient would most benefit from ?

Colonoscopy

Mammography

Pap smear

Pelvic scan

Pancoast tumour is seen with cancer of -

Apical lobe of lung

Lingual lobe

Thyroid

Pyriform fossa

A patient is brought to the emergency room following a seizure. Electrolytes show SIADH. CT Scan demonstrates a lung mass. Which of the following forms of lung cancer is most likely to cause the described electrolyte imbalance?

Adenocarcinoma

Bronchioalveolar carcinoma

Large cell carcinoma

Small cell carcinoma

A 63-year-old woman is seen in the emergency room with acute shortness of breath. There is no history of heart or lung problems in the past. She was recently diagnosed with breast cancer and is undergoing active treatment. On examination, her blood pressure is 120/80 mm Hg, pulse 100/min, and heart and lungs are normal. There are no clinical signs of deep venous thrombosis (DVT). Which of the following investigations is most likely to rule out a pulmonary embolism (PE)?

normal CXR

normal electrocardiogram (ECG)

normal ventilation-perfusion lung scan

normal ventilation scan

A 68-year-old man complains of pain upon urination. A CT scan and a biopsy provide evidence of an enlarged, cancerous prostate gland. Subsequently, he undergoes a radical prostatectomy. Postoperatively, he suffers from urinary incontinence because of paralysis of the external urethral sphincter. Which of the following nerves was injured during the operation?

Pelvic splanchnic

Sacral splanchnic

Pudendal

Superior gluteal

Which of the following immunosuppressants is not used for the treatment of cancers?

Cyclophosphamide

Cyclosporine

Methotrexate

6-Mercaptopurine

In which of the following head and neck cancers, is lymph node metastasis least common:

Tongue

Buccal mucosa

Hard palate

Lower alveolus

Increased susceptibility to breast cancer is likely to be associated with a mutation in the following gene -a) P53 b) BRCA-1 c) Retinoblastoma (Rb) d) H-Ras

ab

bc

ad

bd

In a suspected case of ovarian cancer, imaging work up is required for all of the following except:

Detection of adnexal lesion

Characterization of lesion

Staging

Assess resectability

The group of drugs used as subsidiary medicines in cancer treatment?

Amefostine

Filgrastim

Cytochalasin

All of the above

Most common site for veebral cancer is

Cervical

Lumbosacral

Thoracic

Cervicodorsal

A 6-year-old girl presents with a left breast mass. Her mother first noticed it a day before and is very concerned because both the child's maternal grandmother and maternal aunt have had breast cancer. It is firm, smoothly circumscribed, and slightly eccentric under the left areola. The right breast is unremarkable. You suggest

Immediate excisional biopsy

A mammogram

Repeat examination in 1 month

Genetic testing for breast cancer (BRCA) 1 and 2 mutations

An intravenous pyelogram (IVP) showing hydronephrosis in the work up of a patient with cervical cancer otherwise confined to a cervix of normal size would indicate stage:

I

II

III

IV

Not an epithelial cancer of ovary -

Brenner

Endometroid

mucinous

Granulosa cell tumor

If a life time probability to develop a lung cancer is 25% than what are odds of developing lung cancer in life time is-

3:01

1:03

2:02

4:01

Increased risk of endometrial and ovarian cancer is seen in

Hereditary nonpolyposis colorectal cancer

Peutz-jeghers syndrome

Cowden's syndrome

Ataxia telangiectasia

In Esophageal cancer prognosis is best determined by:

Cellular differentiation

Age of patient

T stage

Length of involvement

Cancer suppressor gene is important in which malignancy -

Retinoblastoma

Malignant melanoma

Liver carcinoma

Lung cancer

All of the following drugs are used in the treatment of metastatic breast cancer except:

Ixabepilone

Abemaciclib

Ribociclib

Sunitinib

A 42 year old man is preoccupied with his health being not in good shape. He feared that his irregular bowel functions mean he has cancer. Now he is preoccupied about having a serious heart disease, despite his physician's assurance that he has no heart disease. What is his most likely diagnosis?

Pain disorder

Hypochondriasis

Delusional disorder

Somatization disorder

Most common gene associated with pancreatic cancer

KRAS

SMAD

P53

Rb

Ifosfamide belongs to which group of anticancer drugs?

Alkylating agents

Antimetabolites

Mitotic inhibitors

Topoisomerase inhibitors

All statements about papillary thyroid cancer are true except:

It is the most common subtype of thyroid cancer

The most common variant, and the one most liable to misdiagnosis is follicular variant

Is not associated with radiation as a risk factor

Diagnosis is made by the presence of nuclear finding and not on papillae formation

Which of the following histologic types of invasive breast cancer has the best prognosis?

Medullary carcinoma

Mucinous carcinoma

Tubular carcinoma

Ductal carcinoma

Anticancer drug causing SIADH as an adverse effect is :

Vincristine

Paclitaxel

Dacarbazine

Cyclophosphamide

Absolute contraindication of conservative breast cancer therapy isa) Large pendulous breastb) History of previous radiationc) Axillary node involvementd) Subareolar lump presente) 1 st trimester pregnancy

be

ad

bc

ce

Cadmium can cause all cancer except ?

Lung

Pancreas

Prostate

Skin

A 55-year-old man presents with a solitary breast mass and biopsy reveals malignant cells. Immunohistochemical staining experiments show that the tumor cells are positive for HER2/neu and cytokeratins 4 and 11 and negative for estrogen receptors. Which of the following is thought to play a role in the development of cancer in the patient?

BRCA2 mutation

Chronic alcoholism

Gynecomastia

Hyperestrinism

A 40 year old lady with breast cancer has undergone MRM and is on Tamoxifen for 1 year. She now has presents with bleeding per vaginum 4-5 times. What is the probable cause:

Bleeding disorder

Endometrial cancer

Ovarian cancer

Cervical cancer

True about breast cancer in pregnancy:-

Occurs in 1 of every 3000 pregnant women

MC non-gynecologic malignancy associated with pregnancy

Ductal carcinoma is MC type, accounting for 75-90% of breast cancer in pregnancy

All of the above

Which of the following is used in the treatment of well differentiated thyroid cancer?

32 P

131 I

99mTc

131I-MIBG

Which one of the following types of stomach cancers carries the best prognosis -

Superficial spreading

Ulcerative types

Linitis plastica type

Polypoidal type

T3 Stage in oral cancer is -

Tumour > 2cm in greatest dimension

Tumour > 4cmin greatest dimension

Tumour > 6cmin greatest dimension

Tumour > 8cmin greatest dimension

All the following indicates early gastric cancer except

Involvement of mucosa

Involvement of mucosa and submucosa

Involvement of mucosa, submucosa and muscularis

Involvement of mucosa, submucosa and adjacent lymph nodes

A study was initiated in 1970 with a population of 5000 adults. They were enquired about their drinking habits to study the relationship of alcohol consumption to the subsequent occurrence of cancer. The study was planned for 20 years till 1990-1995. This is an example of what type of epidemiological study?

Cross-Sectional Study

Case Control Study

Current Coho Study

Retrospective Coho Study

Asbsestosis is associated with which cancer:

Lung cancer

Liver cancer

Colon cancer

Stomach cancer

MC site for Leukoplakia with high risk of oral cancer is

Buccal mucosa

Commisures

Floor of the mouth

Any of the above

Example of radiation-induced cancer is -

Papillary carcinoma thyroid

Follicular carcinoma thyroid

Lymphoma

Hepatoma