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Hormonal therapy is useful if Cancer breast expresses ...

Estrogen receptor

Progesterone receptor

Selling Her 2 neu

VEGF

Which one of the following conditions is considered to be definitely precancerous in the larynx?

Vocal nodules

Subglottic hemangiomas

Leukoplakia

Vocal polyp

The anticancer drug belonging to inorganic metal complexes?

Dacarbazine

Cisplatin

Methotrexate

Vincristine

Which of the following anti-cancer drug is NOT 's'-phase specific:

Methotrexate

Mercaptopurine

Ifosfamide

Thioguanine

Best screening marker of prostate cancer is

a - feto protein

Prostate specific antigen

CA-19-20

CA-125-26

Which of the following agents is used for the treatment of Thrombocytopenia secondary to myelosupressive cancer chemotherapy

Filgrastim

Sargramostim

Oprelvekin

Erythropoetin

Sunder, a young male was diagnosed as suffering from acute myeloid leukemia. He was staed on induction chemotherapy with Anticancer drugs. Induction regimen was successful. Two months later, he presents to OPD with swelling of both the feet and breathlessness on climbing the stairs. He also complains the he had to wake up many times because of breathlessness. Which of the following is most likely responsible for this patient's symptoms?

Cisplatin

Methotrexate

Doxorubicin

Vincristine

A 68-year-old man has a long history of prostate cancer that was metastatic at the time of diagnosis. Over the past 2 months, he has had significant weight loss, loss of appetite, and loss of energy. His current spectrum of conditions can be attributed to which of the following

Platelet-derived growth factor

Fibroblast growth factor

Interleukin-2

Tumor necrosis factor-a

25 year old woman undergoes pap smear at screening camp for cervical cancer. Her test report comes out to be inadequate cervical cytology. What is the appropriate follow up for the patient

Refer for colposcopy

Repeat cervical cytology in 3 months

Repeat cervical cytology in 6 months

Repeat cervical cytology in 3 years

A 56 yr old smoker had renal clear cell cancer. His LFT showed SGOT/PT - 65/45, ALP-465 but USS abdomen does not showed any liver metastasis. What is the likely diagnosis?

Hutchinsons syndrome

Stauffers syndrome

Goldenhar Syndrome

Cornelia De Lange Syndrome

LHRH analogue used in breast cancer -

Cetrorelix

Anastrazole

Leuprolide

Tamoxifen

Which of the following anticancer drugs is not derived from plants?

Irinotecan

Doxorubicin

Paclitaxel

Etoposide

Roopa Devi, a 65-year-old female with ovarian cancer is being treated with cisplatin-based chemotherapy. All of the following are used to limit the toxicity of cisplatin except:

N-acetylcysteine

Slow rate of infusion

Chloride diuresis

Amifostine

Investigation of choice to know depth of cancer invasion is

CECT

MRI

Barium

EUS

The Lymph node to be involved in Cancer Gall bladder to be called as M1 Stage?

Inter aortocaval node

Superior mesenteric node

Coeliac node

Pancreatico duodenal node

Which enzymatic mutation is responsible for immortality of cancer cells:

DNA reverse transcriptase

RNA polymerase

Telomerase

DNA polymerase

Ifosfamide belong to which group of anticancer drugs

Alkylating agents

Antimetabolites

Metotic inhibitors

Topoisomerase inhibitors

Herceptin is used for w hich cancer -

Breast

Thyroid

Cervical

Ovarian

A 72-year-old woman presented with skin changes over her left breast. She had a history of breast cancer 5 years earlier and was treated with a lumpectomy and radiation therapy. What is the diagnosis?

Inflammatory breast cancer

Mastitis

Radiation-induced angiosarcoma

Fat necrosis

The cancerogenic chemical that has a very long latent period is –

Benzopyrine

Vinyl chloride

Asbestos

Estrogens

Trismus in oral cancer patients is severe in those treated with -

Surgery and Radiotherapy

Chemotherapy alone

Surgery alone

Not related to treatment

Not a carcinogen for bladder cancer?

Benzidine

Isopropyl alcohol

Acrolein

Phenacetin

Which of the following is used in the treatment of differentiated thyroid cancer

131I

99mTc

32P

131I-MIBG

Scrotal cancer is seen in which occupation traditionally:

Coal worker

Painters

Chimney cleaners

Spinners of cotton

Most commonly used cordiotoxic anticancer drug-

Doxorubicin

Vincristine

L-Asparginase

Paclitaxol

Which of the following is the investigation of choice for assessment of depth of penetration and perirectal nodes in rectal cancer -

Trans rectal ultrasound

CT Scan pelvis

MRI Scan

Double contrast Barium enema

All are precancerous except -

Lichen planus

Verrucous carcinoma

Submucous fibrosis

Leukoplakia

Simplest investigation to be performed for suspected cancer stomach:

Double contrast radiography

Plain X ray

CT scan

Endoscopy

Management of stage 11B cancer cervix is?

Radiotherapy

Radiotherapy with combination with chemotherapy

Chemotherapy

Hysterectomy

Skin cancers develop due to sun light exposure induced by

UV A rays

UV B rays

UV C rays

UV D rays

Precancerous potential in Plummer- Vinson's syndrome may be due to change in the epithelium like:

Atrophy

Hypertrophy

Acanthosis

All the above

All of the following are pre-cancerous conditions of the lids except:

Naevi

Solar keratosis

Xeroderma pigmentosa

Carcinoma-in-situ

Investigation of choice for High-risk cancer in the female is:

MRI

CT-PET

Mammography

USG

Which of the following is the MOST common histological variant of prostate cancer?

Adenocarcinoma

Sarcoma

Seminoma

Squamous cell carcinoma

A study revealed lesser incidence of carcinoma colon in pure vegetarians than non vegetarians by which it was concluded that (-carotene is protective against cancer. This may not be true because the vegetarian subjects may be consuming high fibre diet which is protective against cancer. This is an example of:

Multifactorial causation

Causal association

Confounding factor

Common association

Approved drug for prostate cancer is

Bicalutamide

Apalutamide

Ibalizumab

Ivacaftor

Which of the following statements regarding cancer therapy with interleukin 2 (IL-2) is true?

It is a B-cell growth factor

It induces a major response in patients with metastatic breast cancer

It induces a major response in patients with metastatic colon cancer

It induces a major response in patients with metastatic melanoma

A patient complains of difficulty breathing through his nose and bony pain in his cheeks, near his nose. Physical examination and CT of the head reveal mass lesions involving the nose, pharynx, and sinuses. CT-guided biopsy demonstrates a non- keratinizing, squamous cell carcinoma. Which of the following disorders is associated with the same oncogenic virus that is the likely cause of this patient's cancer?

Adult T-cell leukaemia

Burkitt's lymphoma

Cervical carcinoma

Hepatocellular carcinoma

Most common variety of vaginal cancer is -

Adenocarcinoma

Squmaous carcinoma

Melanoma

Clear cell

In which one of the following prineural invasion in head and neck cancer is most commonly seen

Adenocarcinoma

Adenoid cystic carcinoma

Basal cell adenoma

Squamous cell carcinoma

Cancer thyroid having least hematogenous spread:

Follicular

Papillary

Anaplastic

Medullary

Adenoacanthoma is which type of uterine cancer

Poorly differentiated adenocarcinoma

Well differentiation Adenocarcinoma

Mucinous carcinoma

Papillary serous carcinoma

Endometrial cancer is associated with all EXCEPT:

Fibromyoma

Endometrial hyperplasia

Dysgerminoma

Granulosacell tumor

Natural elements having anticancer properties a) Nitrosoamines b) Vit. C c) Vit. D d) Carotene e) Selenium

de

bde

be

ab

The most pre-cancerous condition for carcinoma colon is

Familial polyposis

Hamaomatous polyps

Juvenile polyps

Hyperplastic polyps

Small cell cancer commonly metastasizes to -

Brain

Liver

Bone

Kidney

Following the immunotherapy, in patients undergoing renal transplantation, the skin cancer most commonly seen is -

Skin tumors

Kaposi's sarcoma

Hepatomas

Mycosis fungoides

Precancerous condition of Ca stomach is ?

Peptic ulcer

Chronic gastric atrophy

Achalasia cardia

Curling's ulcer

Rupa Devi age 65 year old female with ovarian cancer is being treated with cisplatin based chemotherapy. All of the following are used to limit the toxicity of cisplatin except

N-acetylcycteine

Slow rate of infusion

Chloride diuresis

Amifostine

Investigation of choice for high risk breast cancer in female is

MRI

CT- PET

Mammography

USG

Breast cancer more commonly seen in -a) Increased risk in relativesb) Early marriage < 20 yrs.c) Nulliparad) High fat diete) Who avoided breast feeding

bce

acde

abcd

abde

Most common site of cancer stomach:

Greater curvature

Lesser curvature

Fundus

Antrum

Which of the following anticancer drug is excreted by lungs ?

5–Fluorouracil

Cyclophosphamide

Doxorubicin

Cisplatin

Most common type of HPV associated with invasive cervical cancer is?

Type 6

Type 16

Type 31

Type 45

Most common cancer world wide

Lung

Prostate

Liver

Kidney

A 65-year-old man undergoes a technically difficult abdominoperineal resection for a rectal cancer during which he receives three units of packed red blood cells. Four hours later in the intensive care unit he is bleeding heavily from his perineal wound. Emergency coagulation studies reveal normal prothrombin, partial thromboplastin, and bleeding times. The fibrin degradation products are not elevated but the serum fibrinogen content is depressed and the platelet count is 70,000/mL. The most likely cause of the bleeding is

Delayed blood transfusion reaction

Autoimmune fibrinolysis

A bleeding blood vessel in the surgical field

Factor VIII deficiency

Most common skin cancer in Immunosuppressed individuals is

Malignant melanoma

SCC

BCC

Dermatofibroma

A 40 year old woman has the following family and personal history: her mother died of breast cancer at age 64, she smokes one pack/day, she drinks five or more cups of coffee/day, she has no children, and she takes bih control pills. Which of the following is the most significant risk factor for breast cancer in this patient?

Bih control pills

Caffeine consumption

Cigarette smoking

Family history

The best time to do an endometrial biopsy in a patient with suspected endometrial cancer is which of the following?

9 - 10 day

20 - 21 day

26th day

2nd day

Not true about familial polyposis colon cancer syndrome?

Autosomal recessive

Associated with fibromas and osteomas

Associated with brain tumors

100% incidence of colon carcinoma

Cause of B/L recurrent laryngeal nerve palsy are -a) Thyroid Cab) Thyroid surgery c) Bronchogenic cancer d) Aortic aneurysm

ac

a

ab

bc

Treatment of stage I bladder cancer is -

Radical cystectomy

Endoscopic removal with intravesical chemotherapy

Chemotherapy

Radiotherapy

Which of the following is the etiologic agent in a 70 year old woman with squamous cell cancer of the vulva ?

Lichen Sclerosus

Human papiloma virus

Immunosuppression

Smoking

A 15-year-old boy is injured while playing cricket. X-rays of the leg rule out of a possible fracture. The radiologist reports the boy has an evidence of aggressive bone tumor with both bone destruction and soft tissue mass. The bone biopsy reveals a bone cancer with neural differentiation. Which of the following is the most likely diagnosis?

Chondrablastoma

Ewing's sarcoma

Neuroblastoma

Osteosarcoma

Locally invasive gastric cancer. Investigation of choice to know depth of cancer invasion

CECT

MRI

Barium

EUS

Lynch syndrome is associated with cancers of the:

Breast, colon, ovary

Breast, endometrium, ovary

Breast, colon, endometrium

Colon, endometrium, ovary

Most hereditary ovarian cancers result from germline mutations in the

BRCA1 and BRCA2

MSH2

PMS1

MLH1

Drug useful in breast cancer is -

Tamoxifen

Cyproterone

Testosterone

Chlorambucil

Immunity against cancer cells

Basophil

Eosinophils

NK cells

Neutrophil

Which of the following radioisotopes is commonly used as a source for external beam radiotherapy in the treatment of cancer patients

Strontium - 89

Radium - 226

Cobalt - 59

Cobalt - 60

Estrogen positive breast cancer is best treated by which drug?

Tamoxifen

Clomifene

Glutethemide

5-FU

A 50-year old male, working as a hotel cook, has four dependent family members. He has been diagnosed with an early stage squamous cell cancer of anal canal. He has more than 60% chances of cure. The best treatment option is:

Abdomino-perineal resection

Combined surgery and radiotherapy

Combined chemotherapy and radiotherapy

Chemotherapy alone

Which of the following infection predispose to cancer?

Schistosomiasis

Taenia solium

Taenia saginata

Strongyloides

Screening of cervical cancer at PHC level is done by?

History and clinical examination

Colposcopy

CT scan

PAP smear

Cancer can be prevented by ingestion of-

Beta carotene

"VitaminC & E"

Selenium

All the above

If a 95% Confidence Interval for the prevalence of cancer smokers aged > 65 years is 56% to 76%, the chance that the prevalence could be less than 56% is -

Nil

44%

2.50%

5%

Risk factors for skin cancer are all Except

Solid organ transplantation and chronic immunosuppression

Blonde hair and blue or green eyes

Use of tanning beds, outdoor occupation/sunexposure

Use of sunscreen lotions

Roopa Devi, a 65-year-old female with ovarian cancer is being treated with cisplatin-based chemotherapy. All of the following are used to limit the toxicityof cisplatin except:

N-acetylcysteine

Slow rate of infusion

Chloride diuresis

Amifostine

Monoclonal antibody used in cancer is

Rituximab

Cisplatin

5-fluorouracil

Methotrexate.

Which of the following types of cancers is Human Papilloma Virus (HPV) most commonly associated with?

Prostate

Anogenital

Oral

Lung

Single file pattern is seen in breast cancer type-

Intraductal

Infiltrating lobular

Infiltrating ductular

All of the above

Which one of the following is the most sensitive and specific screening test to detect Breast cancer:(2001)

Regular X-ray

Self breast examination

Mammography

Regular biopsy

Herceptin is used for which cancer ?

Breast

Thyroid

Cervical

Ovarian

A 62-year-old woman who is a heavy smoker has an advanced lung cancer that spread into her right third intercostal space posterior to the midaxillary line. If cancer cells are carried in the venous drainage, they would travel first to which of the following veins?

Superior vena cava

Right superior intercostal vein

Azygos vein

Right brachiocephalic vein

What is the use of injecting methylene blue dye in a breast cancer surgery

Tattooing for biopsy

Marking of tumor cells

Sentinel lymph node biopsy

Photodynamic therapy

All are true of supraglottic cancer except:

Earliest symptom is hoarseness

Most aggressive of laryngeal cancers

High incidence of nodal metastases

Commonest site in supraglottic region is epiglottis

A 62-year-old woman presents for annual examination. Her last spontaneous menstrual period was 9 years ago, and she has been reluctant to use postmenopausal hormone replacement because of a strong family history of breast cancer. She now complains of diminished interest in sexual activity. Which of the following is the most likely cause of her complaint?

Decreased vaginal length

Decreased ovarian function

Alienation from her partner

Untreatable sexual dysfunction

Smoking causes all cancers except:

Carcinoma endometrium

Oral cancer

Kidney cancer

Bladder cancer

Drug used in estrogen dependent breast cancer -

Tamoxifen

Clomiphene citrate

Estrogen

Adriamycin

All the species of HPV commonly are associated with high malignant potential causing cervical cancer except?

HPV 16

HPV 6

HPV 31

HPV 18

A sexually active woman was seen for a routine gynecologic exam that included a Pap smear. The report indicated cervical intraepithelial neoplasia. In situ hybridization showed the presence of human papillomavirus (HPV) type 16 genomes within the neoplastic cells. Which of the following processes is required for HPV to lead to the development of cancer?

Integration of the viral genome

Loss of HPV E6 and E7 genes

Mutation of the virus

Viral replication

A 50-yrs-old woman is diagnosed with cervical cancer. Which lymph node group would be the first involved in metastatic spread of this disease beyond the cervix and uterus?

Common iliac nodes

Parametrial nodes

External iliac nodes

Para-aoic nodes

A 69-year-old man has lost a friend to prostate cancer, and would like to be evaluated for the disease. He has no urinary symptoms. Which of the following tests is most likely indicated to screen him for prostate cancer?

prostate ultrasound

digital rectal examination (DRE)

DRE and prostate specific antigen (PSA)

PSA

All of the following benign conditions are associated with increased rates of gastric cancer except:

Pernicious anemia

Multiple endocrine neoplasia type I (MEN 1)

Adenomatous polyps

Chronic atrophic gastritis

Which of the following functions is associated with the oncogenic L 'MYC' in lung cancer -

Protein kinase

GTP binding protein

Nuclear binding protein

Growth factor

Breast conservation surgery is indicated in one of the following conditions -a) T1 breast tumorb) Multicentric tumorc) Extensive in situ cancerd) T4b breast tumor

a

bc

ad

ac

Indicated technique for histopathological examination of utrine cancer for mass screening.

Exfoliative cytology.

Brush cytology

FNAC

None of the above

The appropriate statistical test to find out obesity as a significant risk factor for breast cancer is:

Student's paired 't' test

Student's unpaired 't' test

Chi-square test

Wilcoxon's signed rank test

All of the following anticancer agents cause bone marrow depression except -

Chlorambucil

Daunorubicin

Doxarubucin

Flutamide

A 55 year old sexually active male with stage Tlb prostate cancer must be offered -

Radical Prostatectomy

Orchidectomy

Hormone Ablation

TURP