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This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Tricyclic antidepressants have demonstrated analgesic efficacy for NP entities such as post-herpetic neuralgia and diabetic neuropathy, and their use is extrapolated to other NP entities (Mercadante, Arcuri, Tirelli, Villari, & Casuccio, 2002); they were found to be useful for phantom limb pain in children as early as 1989 (Rogers, 1989), taking effect within 1 week at doses lower than those required for depression (Mercadante, Arcuri, Tirelli, Villari, & Casuccio, 2002). |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Therefore, there is an urgent need to identify effective interventions for the prevention and control of hypertension in Xinjiang. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | To further characterize the molecular events leading to chromatin condensation, we performed ChIP experiments using anti-HDAC1, HDAC2, HDAC3, MeCP2, MBD3, Kaiso, and NCoR antibodies, demonstrating HDAC1, HDAC2, and MeCP2, but not HDAC3, MBD3, Kaiso, and NCoR, to be involved in BIM silencing (Figure 5, D and E). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This approach is highly dependent on labeling techniques; therefore, our observation suggesting no differences according to HLA status may not have functional relevance. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This small uncontrolled study is the first Hawai‘i-specific experience with early childhood vision screening using a portable hand-held photoscreener. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Increases of IL-6 levels have been reported to correlate with increased fibrinogen levels, confirming the link between inflammation and procoagulant changes of the hemostatic system 27. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Bone fracture was seven times as common in coeliac disease patients as in controls. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The defect described herein is a more extreme example, with complete failure of action potential initiation by a normal EPP (Fig. 2). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Although we know of no test of this among cannabis users, most studies using IVR (Helzer et al, 2002) or Ecological Momentary Assessments (Shiffman, 2009) have failed to find reactivity with alcohol and tobacco users. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | According to the two-route account, hubs of the language and object networks would have to interact with each other through reciprocal connections to enable object naming. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In a previous one-year weight loss intervention, eating competence increased as BMI decreased among obese individuals [12]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Loss of function in heterozygous DICER1 germline pathogenic variants and somatic missense variants of DICER1 result in the abnormal production of miRNAs41–45. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Supernumerary optimal embryos, these are cryopreserved and transferred in subsequent cycles can improve the overall pregnancy rates. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The mechanisms associated with these cortical changes may have relevance for the further understanding of, and subsequent therapeutic approaches to a number of different mental health disorders. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Potential Contamination of the Straw Board Straw board could have been contaminated either before or after manufacture. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Accordingly, Martino et al[18] showed that patients with endometrial cancer who underwent robot-assisted hysterectomies required a fewer analgesics and had less severe initial postoperative pain than did those who underwent laparoscopic surgery. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Moreover, not a single trial showed any difference in the readmission rate. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In contrast, while allele frequencies for GYPCΔex3 were higher in the Wosera than Liksul, the distribution of these alleles was in Hardy–Weinberg proportions in both populations and suggests that GYPCΔex3 alone does not confer a selective disadvantage. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our data also support a role for TNF in activating NFAT signaling leading to altered cholesterol metabolism via reduced ABCA1 expression, thus contributing to kidney injury. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The discussion around value-added scores can be expanded to focus not just on replacement of teachers with low value-added scores, but also on the training and development of teachers. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We suggested that this shape of form abnormal was related to renin-oriented aldosterone hypersecretion, which could not be reckoned as Independent incretion. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The interactions are necessary since the attributes of the object endow the word with part of its given meaning at the same time that the word is one of the numerous secondary (e.g. acquired rather than innate) associations of the object.The current results strengthen this separation of functional realms by emphasizing the selective impact of left temporal tip atrophy on the integrity of verbal rather than non-verbal representations of objects. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In other words, Oxford House participants showed an overall increase in tolerance compared to usual care participants, but those men and women who lived in Oxford House for a longer period seemed to have had a greater chance of benefiting from the communal-living experience. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | These properties are likely to favor image quality and, potentially, diagnostic accuracy, although this latter feature remains to be further assessed in dedicated ancillary studies. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | These findings might indicate that prayer can be a useful factor in pain management but only for pain patients who are religious. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Therefore, improving and standardising the recording of patient risk factors and clinical symptoms in sample test-request forms would provide useful information on the burden, risks and acquisition of EV-D68. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Clinical response was also shown to be influenced by serum antibody half-life, with values ranging from 127 to 3708 hours following this standard infusion protocol39. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Finally, from a geneticist’s point of view, the contradiction between the present study and the initial observations [13] can be explained by the presence of linkage disequilibrium (LD). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The first season was unusual compared with subsequent ones in its timing and may have had a lower age distribution, the reasons for this are unclear but could be consistent with the arrival of emerging EV-D68 within Wales. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This was particularly apparent in Patient 1 where peripheral B cells repopulated but without a change in disease activity and radiological features showing stable and, to some extent resolving, inflammation. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Information processing speed is also known to decline with age [Der and Deary 2006; Salthouse 1996], and low scores on the DSST have been associated with both incident mild cognitive impairment (MCI) and dementia [Lopez et al 2003a; Twamley et al 2006]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our initial sample size estimate is based on a rate of relapse of 40% in the placebo group. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The negative association between availability to fruit and vegetable vendors and fasting glucose may have been a chance finding due to variability in fasting glucose levels or multiple statistical testing in our study, and needs to be confirmed in further studies. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Clinicians managing such patients should consider establishing a prostate cancer multidisciplinary clinic if not already present at their institution. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The onset is neonatal, the disorder is normokalemic, the attacks selectively involve bulbar and respiratory muscles, physiologic rates of stimulation decrement the CMAP abnormally, and the muscle fiber membrane potential is normal when action potential generation fails. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Relative to other published studies, (Romano, Bloom, & Syme, 1991) levels of stress, daily hassles, and lifestyle chaos were high in the sample. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This finding was expected as the GRS63 includes nearly four times as many genetic risk markers for BMD compared to the GRS16. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | New tools such as RDTs for malaria and other infections have the potential to give para-professional providers a limited but important role in diagnosis and treatment algorithms. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Second, the tributaries of the CS were evaluated. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | On the other hand, it is possible that more resilient patients have a higher QoL and are more likely to take medications. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, in a previous report, the sensitivity for identifying patients with coronary stenosis was found to be rather high (88%) for stress SPECT recorded with the biker position (15), and the rate of normal stress D.SPECT images reached 97% in patients with a less than 10% likelihood of coronary artery disease (normalcy rate), strengthening the general consideration of a rather low rate of artifacts with the biker position (15). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In this Saudi sample, the mean arch widths were narrower when compared to a Turkish sample,19 a North American sample, a South American sample, a Korean sample,20 and an Egyptian sample;21 on the other hand, it was close to a Malay sample.22 These ethnic groups’ differences in arch dimensions explain the need for specific orthodontic arch wire for each patient, based on the initial arch form. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | That study showed a statistically signifi cantly better EQ-5D outcome (by 0.03) in favor of the PA group (Lindgren et al 2014). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Therefore, many researchers have attempted to develop a prenatal, noninvasive, and rapid method of diagnosing intrauterine inflammation. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We carefully designed our subgroups for analysis a priori, and had sufficient data to accurately assign study subjects to subgroups with confidence, minimizing the likelihood of bias related to misclassification. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | To our knowledge, this is the first evaluation of the Xpert GBS assay in gastric fluids. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The clinical significance of the slower transit in HLA-DQ2/8-positive patients is unclear, given the relatively small sample size and the multiplicity of transit end points, some of which (e.g., SB transit and ascending colon emptying time) were not different according to HLA-DQ status. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We suggest that, if possible, attempts to investigate additional phenotypes that may be associated with a variant should not use individuals that have been ascertained on the basis of the phenotype of interest; instead, they should be drawn from independent cohorts and selected solely on the basis of being a carrier of the variant under study. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, significant osteomalacia can be present even with normal bone mineral density, serum calcium phosphate, and parathyroid hormone, and bone biopsy may be appropriate in some patients. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The novel result of our study was the association of eating competence with decreased risk of metabolic syndrome, as defined by the Joint Interim Statement criteria [32], and particularly, improved peripheral insulin sensitivity, as indicated by higher Matsuda ISI and lower fasting insulin in ECPs than in NECPs (Table 3). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, we assume that the antimetastasis activity of ANP does not solely depend upon the suppression of E-selectin, because extravasation of cancer cells in the metastatic process is regulated by many other steps. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Zhao et al. reported that the AA allele of DICER1 rs3742330 is related to an increased CRC risk19, while Cho et al. determined that the DICER1 rs3742330 AG genotype leads to an increased risk of colon cancer but not rectal cancer66. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Such a discrepancy is apparent in our results because 47% of staff who responded reported personal experience of pacemaker explosions at some point in their career, but only 41% of staff estimated no events occurring in general. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In addition, experimental evidence has linked the deleterious effect of partial/complete airway obstructions, and accompanying hypoxemia and hypercapnia to the cardiovascular system through several processes, including activation of the sympathetic nervous system, endothelial dysfunction, inflammation, oxidative stress, vascular smooth muscle cell activation, platelet activation and thrombosis14. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Longer follow-up is necessary to confirm this early favourable outcome. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | From the Sixth KYRBWS-VI data in 2010 in Korea, smoking rate of aged 12–18 was 16.6% in boys and 7.1% in girls [30]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Increased density of ready-to-eat food outlets and decreased distance to nearest ready-to-eat food outlet were associated with higher risk of type 2 diabetes in 347,551 UK Biobank adult participants (Sarkar et al, 2018). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Another interesting aspect that should be considered for further investigations is the finding that certain metabolites strongly correlate with microbial community structures which would allow gaining insights into microbiome–host interactions, also in context of certain diseases and therapeutic interventions [50,51]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | There are, however, some limitations that must be considered. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This study is the first step in researching factors influencing QoL in HIV patients in Georgia, and it highlights the need for future studies to further direct evidence-based action towards improving QoL in this population. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Future follow-up of our cohort will be important to assess whether the associations we observed persist later in life. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | It appears, therefore, that left anterior temporal lobe atrophy leads to an excessive blurring of intra-category compared with inter-category boundaries, but predominantly in selecting verbal associations of objects. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Indeed, most barriers endorsed by our participants emphasized internal or cognitive factors including lack of motivation, lack of energy, not wanting to change habits, and feeling better when eating unhealthy food. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Such a decline in BC associated with a chronic disease such as TB is not surprising considering the extent of pathological damage observed in individuals with advanced infection. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, the identification of MeCP2, an MBD commonly associated with the SIN3 complex, strongly suggests the involvement of the latter. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This study provides the strongest evidence to date that sustained, carefully planned, differentiated literacy instruction supported by technology and using the best assessments and research-based strategies available is more likely to be effective than what is typically seen in classrooms. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In our review, oral short acting and long acting opioids were used in 60.3% and 48.3% of patients respectively, while intravenous opioids were used via PCA or non-PCA in 58.9% and 93.4% of patients respectively. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Furthermore, while the functional association between the mitotic checkpoint and histologic grade has not been well studied, a study of invasive ductal breast carcinomas has shown that disregulation of components of the APC [19] is correlated with higher histologic grade in these tumors. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Four other prospective studies (Helzlsouer et al, 1994; Toniolo et al, 1995; Berrino et al, 1996; Dorgan et al, 1996) have also reported an association between relatively high serum concentrations of oestradiol and increased risk of breast cancer, while two others have reported results that appear negative but that may be statistically compatible with ours (Wysowski et al, 1987; Garland et al, 1992). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | First, the design of the study being cross-sectional in nature and conducted among non-diagnosed participants, limits the implications of the present research, it does however suggest that emotion dysregulation and dispositional mindfulness and social support may play a part to aggravate symptoms of social anxiety. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In addition, the sample sizes examined –376 subjects for LUMA and 332 subjects for Illumina 450 K Methylation are fairly large datasets, allowing for sufficient power to detect significant methylation changes if present. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Hypothermia exposures of the pups in these studies, and the subsequent equilibration period, inevitably required maternal separation of the pups for periods of 60 minutes and above, and therewith closely resemble our stress paradigm. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | HLA system is the most important region in the human genome related to infection, inflammation, autoimmunity, and transplantation medicine31. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | One of the kittens had been adopted by an employee. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Lower than therapeutic doses of antidepressant drugs are frequently used in long-term treatment to overcome side effects that might jeopardize patient compliance. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | To our knowledge, this study represents the largest examination of HCV screening of adults with SMI served within the public mental health system 4. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our study provides several novel findings. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The importance of these end points of cortisol feedback is that ACTH secretory-burst mass and pulsatile ACTH secretion denote amplitude control (35); basal ACTH secretion largely signifies constitutive ACTH release (citation); and ApEn quantifies ACTH secretory regularity, a validated barometer of feedback adaptations (citation). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Unfortunately, no WGS data are available for the Egyptian isolate to evaluate such a link. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This attitude may have indicated a tendency to use more proactive coping strategies and thus, use prayer as a positive coping technique. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This, in combination with a relatively small number of probes, contributed to the low P values estimated by our permutation testing (Table 2). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Finally, continued rigorous research on effective instructional models is vitally needed to provide the cumulative benefits demonstrated in the present study. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This understanding is essential to confronting the complex relationship between poverty and illness, and prioritizing interventions that address these two inseparable problems. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Barriers related to structural issues—the least reported barriers to behavior change in our study—have been the focus of rural health disparities research but such barriers appear to be only one of a series of challenges to behavioral change. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Case 4 demonstrates the potency of a chronic negative calcium balance in stimulating the parathyroid glands, with the apparent development of an autonomous parathyroid adenoma in this patient. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In a similar interventions in managed care settings, Green, et al found a greater treatment effect in patients with baseline SBP ≥160 mm Hg and Magid, et al found greater treatment effects in patients with diabetes or CKD but did not perform a statistical interaction test[citation]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Korovessis et al. [18] have shown that the proximal bone mineral density measured immediately after operation around ZweymuÈllerAlloclassicÒ-SL stem remained unchanged after 4 years. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Interestingly, only genes implicated in mitotic entry or the mitotic checkpoint were suggestive of gene-level associations. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Two out of the 11 participants who received the minimum intervention dose were in the pre-contemplation stage; had these participants been excluded, the intervention would have been successful in 78% of participants. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our findings suggest that the best opportunity to reduce pre-hospital delays is during the period in which patients are seeking help outside the home, before the decision to escalate to the referral hospital is made. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This indicates that as the participants beliefs in personal need and concern regarding analgesics become stronger, they take a higher total weekly dose of analgesic. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Breast cancer screening programs have been actively conducted in Turkey to national standards of Cancer Early Diagnosis, Screening and Education Centers, which were established under the Directorate of Public Health. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | These mixed findings may relate to the complexity of measuring crime, which is likely to be sensitive to time of occurrence, location, people’s perceptions, and social context [Citation]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This is predominantly related to a higher dropout rate than expected (see Figure). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The role of vitamin D deficiency in the metabolic bone disease of coeliac disease is also debated; it is not certain whether hypovitaminosis D contributes to the intestinal calcium malabsorption. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | As a minimum, therefore, it is essential to include appropriate geographically-matched controls (as was the case in the original reports that are the subject of our replication study). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Of 841 acetabular replacements with the same CLW component, Decoulx et al. reported annual cumulative rates of 88.3%, 90.9% and 87.4% respectively using hip pain, radiographic stability and revision as end points, for the smooth component versus 96.4%, 100% and 99.8%, respectively, for the grit-blasted [7]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The results of this study show that probability of developing atopic dermatitis was positively associated with increasing stress levels (very high, high, and moderate compared with none) only in boys. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The finding that treatment with demethylating agents is able to completely revert the binding of MeCP2 to the BIM locus (Figure 5F) suggests that BIM silencing could occur through the following steps: CpG methylation→binding of MeCP2 to methylated CpGs→recruitment of SIN3 core-pressor complex→deacetylation of histone tails→chromatin condensation (Figure 7). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In addition, rs7574865 has been shown to influence the mRNA level of STAT4 in our published HBV-related HCC GWAS13. |