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This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Second, DNA damage is a possible cause of tumorigenesis69. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | There are several possible explanations for this. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The reported disproportionate hyperinsulinaemia in carriers of these deletions is reminiscent of the phenotype of SH2B1 knockout mice [30], which previously led to the suggestion that haploinsufficiency of SH2B1 is the primary cause of obesity in these individuals [10]. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Thus, the identification of new downstream targets of NFAT activation in podocytes is crucial to the development of new therapeutic strategies. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Alternatively, non-poor adults may be prioritized, and encounter the fewest delays because their households are the most willing and able to pay. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Population incidence of confirmed cases in Wales is highest for children younger than five years, as is the number of ICU cases; however the risk for ICU admission appears higher in adults aged 65 years and older. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | A scientific investigation on some patients undergoing oncologic treatment for breast cancer revealed that 84.8% of the patients noticed the disease themselves. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Thus, D-dimer levels track the severity of disease progression and inflammation. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Poor follow-up has been cited as a major problem in many community screening projects 7,8. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | A low oxygen concentration significantly improves the developmental potential of pre-compaction stage embryos, resulting in a positive effect on subsequent blastocyst cultivation. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our findings not only reinforce the superior sensitivity of diffusion tensor MRI for detection of subtle changes in brain white matter but also highlight the significant correlations between early white matter development and later outcomes. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | There is evidence from longitudinal studies that integrated development interventions have already had a positive impact on health seeking as well as health outcomes elsewhere in Bangladesh [49, 50]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | B cells also appear to play an important role in GPA granuloma pathogenesis. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our study demonstrated the induction of cellular death in RTCs incubated with CRS Type 5 plasma. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In our study, rs7574865, which was located in the third intron of STAT4, was significantly associated with the risk of progression to LCs in patients with CHB. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | For the first time, we have identified elevated PWVcf, increased intima-media and adventitia echodensity, abnormal ABI, and increased ICA mean flow velocity as pervasive disease features in HGPS. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Naming errors fit this classification only if the unnamed object as well as the word denoting the object had been accurately defined and also if the two had been accurately matched to each other on two separate pointing tasks. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Nunez et al studied the effects of exposing newborn Hooded rat pups to 5°C and measured a significant decrease in occipital cortical thickness, predominantly with 30-60 minutes of cold exposure; these effects were more pronounced in male compared to female rats. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our results show that a substantial number of anomic errors for relatively common objects in patients with predominantly left temporal tip atrophy can actually arise from pure lexical retrieval impairments despite the preservation of the relevant word and object knowledge. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Whether we should take an aggressive approach to meta-static disease simply because it is available and whether this approach actually helps patients still needs addressing. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The interval from first seeking help to the household’s decision to escalate care to the referral hospital was longer for adults from poor households compared to non-poor. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Noninvasive diagnostic tools used to assess the risk of HCA include measurement of maternal serum CRP levels and leukocyte counts, but these conventional infection markers, when used alone, have poor diagnostic value in distinguishing patients with HCA from those with no placental inflammation. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We show here, that a relatively short, combined psychosocial/physical stress protocol in neonatal Balb/CByJ mice, results in increased corticosterone levels during the stress hypo-responsive period (Sapolsky & Meaney 1986) and leads to significant changes in somatosensory cortical size and architecture in Balb/CByJ mice. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The two gene pairs we identified for use in predicting which patients will develop distant metastases of prostate cancer after undergoing RRP were TPD52L2/SQLE and CEACAM1/BRCA1. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Moreover, attention should be paid to negative re-appraisal aspects of prayer as well. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Comprehensive studies are needed to advance our understanding of the relationship between the blood and genital compartments among those both on and off ART, as well as specific factors within the genital tract that drive seminal plasma HIV-1 RNA levels. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The present phenotype differs from that of periodic paralyses associated with hitherto identified mutations of SCN4A. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | These findings suggest that the genetic influence on BMD change is different from that on peak BMD, highlighting the need for well-powered GWAS meta-analyses on BMD change to identify genetic risk markers related to bone loss. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Several studies have investigated the population structure of ST131 with WGS data and found a sublineage, C/H30, defined by the presence of the fimH30 allele. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Increased spine densities, in were observed under all separation conditions in layers II/III, but were most pronounced following separation on PND 5-7 when significantly increased volume in basal dendrites also was seen. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | An assessment of depression, anxiety, and coping using specific and objective tools would be helpful to correlate our findings with these measures. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The mobile colistin resistance gene mcr-1 has been reported in ESBL-producing E. coli ST410 in Brazil (24) and Germany (25) but was not observed in our 127 isolates. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | An almost 10% lower tomographic count sensitivity was documented in the present study for the biker position than for the supine position. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We observed significantly increased in vitro levels of apoptosis and necrosis in RTCs incubated with plasma from CRS Type 5 patients compared to controls. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Now few laboratories have attempted to compare the difference among primary aldosteronism, chronic primary kidney disease and essential hypertension. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | It is possible that, as in prior studies, (Solomon, et al, 2005) short-term process outcomes (e.g. speaking with a cessation counselor) do not translate into longer-term sustained smoking cessation outcomes. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Despite confounding effects by factors such as gestational age at birth, these correlations remain significant in many brain white matter regions. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Since BMD is sometimes known, it is crucial to also evaluate the clinical utility of GRS63 for fracture discrimination and reclassification in a BMD-adjusted base model. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This technique may offer anesthesiologists prospects for establishing a better, direct assessment of the patient–ventilator interaction and a more protective mechanical ventilation protocol. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | How might patient navigation be effective in linking patients to treatment? |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | AKT is key target molecule in the downstream of phosphoinositide 3 kinase and activated AKT is involved in a series of biological progresses, such as cell survival, growth and proliferation[citation]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Thus, at first glance, increases in spine and dendritic volume in the Bock et al study appears to be in conflict with the thickness decreases we observed in layer II/III in our STR-B mice, and certainly the opposite as seen by Gibbs and Kolb. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Recent in vitro studies have demonstrated that gliadin interacts with the chemokine receptor CXCR3, leading to increased zonulin release and increased intestinal permeability (21), possibly through activation of the innate or adaptive immune system, leading to an inflammatory response (11). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, it is difficult to achieve complete pain control, and consensus about treatment options and dose titration is lacking (Mercadante, Arcuri, Tirelli, Villari, & Casuccio, 2002). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The brightness of an image is determined by the number of returning echos, which is proportional to the density of the tissue being evaluated.21 We found that the intima-media complex in HGPS is of normal thickness, but abnormal echodensity. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | While all other components of MPI can be ascertained based on household characteristics preceding the illness, nutrition status of the household must be measured at the time of interview, and could potentially be affected by rapid weight loss as a consequence of AFI. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The ratio of cartilaginous to membranous vocal fold in the rat is 2:1 (whereas this ratio in human is 1:2). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Median LOS was 5 days, and it was generally shorter than the results presented by other authors [34–37]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The positive predictive value of a positive screen also varies widely by age. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In comparison, Patient 3 demonstrated significant PR3-ANCA antibody production without evidence of peripheral B cell repopulation, which emphasizes the need to consider granulomata in GPA as B cell containing tertiary lymphoid structures pivotal to driving the relapsing disease course. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The potential public health and clinical implications of our findings are worth noting. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We cannot rule out the possibility of type-II error in our study, if the MCID is less than 10 points as we used. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This approach depends only on administered dose and CL and provides an integrated assessment of drug exposure rather than relying on a single point estimate. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | For now, a definition based on up to five detectable lesions is widely employed and is reasonable for use. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Moreover, this study demonstrates that a reduced margin of safety for neuromuscular transmission may occur in the setting of a normal EPP. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Early reports proposed the use of IBW based on desirable weight for height tables; however, the limitations of this approach in patients with obesity led to the consideration of “obesity-adjusted” scalars, such as adjBW, DBW, and LBW (4, 5, 9). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Also, future research may examine how changes in tolerance may be related to participants' own perceptions of stigma in regards to their addictions. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The low incidence of serious PPCs in both groups can be associated with rapid postoperative rehabilitation and decreased perioperative morbidity and mortality in patients undergoing laparoscopic abdominal surgery. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | A negative serologic test result may therefore be helpful in excluding C. trachomatis infection, given that enough time has elapsed since the time of exposure for an antibody response to develop. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Pacemaker explosions are potentially costly for the crematorium owner and may lead to legal proceedings against funeral directors, physicians and health authorities to recover losses. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Plasma concentrations of clusterin have been reported to be associated with atrophy of the entorhinal cortex and more rapid global cognitive decline in AD patients [Thambisetty et al 2010], and were also negatively correlated with global cognitive function and with attention-processing speed as measured by the DSST in 664 participants in the Sydney Memory and Aging Study (mean age 78 years) [Song et al 2012]. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Future interventions must consider incorporating multiple levels of influences to address these deeply embedded barriers that cannot be addressed by cognitive, social, and ecological strategies alone. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Consistent with previous studies, the scales on which the highest proportions of individuals scored in the clinical range were Masculinity/Femininity and Psychopathic Deviate3,5,28,31,36,37. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | There were several limitations to our present study of note. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Schedule B was slightly less conservative, as the maintenance dose was reached in the first visit by 30 min, separated by administration of 0·2 and 0·3 ml of the maximum concentration vial. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | To our knowledge, there is no routine collection of data on explosions in UK crematoria. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The positive effect on blood pH and serum bicarbonate levels is evident in our study. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Over half of ETC + navigation participants did not receive the minimum intervention dose. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Also, we had limited information on other factors that can influence genital tract inflammation, such as CMV serostatus 14,18. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Twelve months after ventro-dorsal spondylodesis, one patient developed reactivation of the infection in the same segment. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Humans have longer pharyngeal ‘dwell’ times before triggering of a pharyngeal swallow and oral residue during larger bolus presentations or continuous eating and drinking [67, 70]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, the present study found that regardless of educational, socioeconomic or demographic status, having a high incidence of breast cancer in the family plays the greatest role in determining whether an individual practicies BSE. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | An increasing prevalence of diabetes mellitus (DM) has been reported in patients with primary aldosteronism (PA), and they suggested that diabetic dyslipidemia and modification of circulating lipoproteins should promote adrenocortical aldosterone synthesis [33]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Again this is not suitable for patients undergoing an emergency procedure. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The traditional univariate analysis detected significant association with fourteen risk factors while the Lasso logistic regression produced a sparser model with eight risk factors. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Epigenetic silencing can be triggered by CpG methylation through two main mechanisms: DNA methylation can repress transcription by directly impairing the binding of transcriptional activators to cognate DNA sequences [47,48] or MBP can bind to methylated DNA sequences, thus recruiting multi-protein corepressor complexes carrying HDAC activity. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Based on previous research in a group of 10 patients with TBI, which reported condition 6 of the SOT to be significantly associated with the physical component of their DHI,17 we expected vestibular integration to be a significant predictor in our analysis. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In previous studies, the proportion of ECPs has varied between 18% and 53% [6,7,9,10,12,14,33]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | More than two-thirds do not meet the Australian recommendations for moderate-intensity physical activity, and nearly 80% do not meet recommendations for vigorous-intensity activity. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Obviously, at this time, patients were not fully integrated into normal life, and an accurate assessment of general state of health and pain is not possible. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We have not seen breakage of a ceramic head or separation between the polyethylene liner and the metal backing. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | While the epigenetic silencing of BIM may play a crucial role in protecting ALCL cells from apoptosis, other mechanisms leading to the down-regulation of BIM have previously been identified. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | One liability of the current study is the lack of biological validation of self-reports. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Too little, too late? |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | There is, however, considerable interindividual heterogeneity in the location of initial peak atrophy sites and the trajectory of progression. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In addition, enhanced surveillances and/or follow-up studies on EV-D68 cases are needed to better understand the risks, duration of illness, length of hospital stay, patient outcomes and long-term sequelae. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Therefore, the results from this study should be interpreted carefully. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | A high intake of lutein/zeaxanthin was inversely associated with CRC risk in G allele carriers (AG + GG) compared with that in AA homozygous DICER1 rs3742330 carriers. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The absence of category specificity in the current study may thus reflect the paucity of major peak atrophy sites in these basomedial parts of the temporal lobe. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Although participants were satisfied with the program and had low rates of attrition, this inward focus may have unwittingly undermined its success. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Among the Shuar, immune-related tradeoffs appear to explain much of the ∼1-cm/y growth rate deficit that children face relative to international standards (27) as well as the modest secular increase in stature accompanying economic development (63). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This may reflect higher utilization of qualified private doctors by non-poor adults, compared to poor adults and children, who were more likely to consult unqualified practitioners. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Both raw and roasted almonds showed potential prebiotic effects on intestinal bacteria and metabolic activities, showing a stimulatory effect on fecal Lactobacillus spp., and Bifidobacterium spp. [40]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | With the coroner's certificate now accounting for about a third of disposals16, it may be that some pacemakers remain in situ. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In this study, high lutein/zeaxanthin intake was strongly inversely associated with reduced CRC risk in all anatomic subsites, including the proximal and distal colon and rectum. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Associative anomias and interpretation of object knowledge Naming errors were considered associative if the picture of the unnamed object or the word that represented its name could not be defined verbally, or if the two could not be matched accurately in at least one of two pointing tasks. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Krödel and others [9] have described the possible failure of ventral fixation in patients with an osteoporotic bone structure. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Although this study shows that gender differences exist with regard to social anxiety with girls reporting higher symptoms, further studies and integration of findings with existing theories is necessary to enhance the understanding of gender differences in social anxiety, thus facilitating gender-sensitive and specifically-tailored policy implementation for both boys and girls with social anxiety. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our study revealed that HIV-infected persons with a CD4 cell count ≥200 cells/mm3 are more likely to have better general QoL as compared to those with a CD4 cell count <200 cells/mm3, after adjusting for other predictors of QoL. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Therefore compared with other studies investigating CIN in ICU patients, our overall incidence is low 37. |