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This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | If this were done, we would have an accurate record of the frequency and consequences of explosions. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Improper specimen collection for direct specimen testing, such as collection of specimens with suboptimal cellular material, is one possibility. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, the period after the start of bypass is often characterized by an unsteady blood flow return, resulting in unsteady blood and gas flows for a period, which is not always foreseeable. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The putative mechanisms whereby increased permeability and reduced TJ expression might mediate IBS-D symptoms are increased water flux, resulting in looser-consistency bowel movements, and visceral hypersensitivity, as demonstrated by Bertiaux-Vandaële et al. (3), who observed association of lower occluding expression with more severe abdominal pain. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The goal of ARR is to provide a balance between missing clinically cancer and performing unnecessary adrenal venos sampling (AVS) in primary aldosteronism. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | These controversial results concerning the postoperative pain intensity and opioid requirement between laparoscopic surgery and robotic surgery may partly be explained by differences in the targets of operation (urologic vs gynecologic), criteria of opioid administration, and surgeon's experiences. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | First, a higher percentage of intervention participants had engaged in smoking cessation treatment by three months after study entry relative to control participants when the minimum navigation intervention was achieved (70% vs. 43%) – a difference which is clinically, although not statistically, significant. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In other clinical studies, obese premenopausal women exhibited greater percentage inhibition of ACTH and cortisol concentrations compared with obese men during low-dose (1 mg) dexamethasone suppression (23). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The effect is not only shortening of the LOS but also a significant reduction of postoperative complications without an increase in readmissions. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | A subsequent sampling of two patients resulted in the detection of two ST410 isolates in both samples, the first patient with 11 SNP differences between the genomes of isolates collected 13 months apart and the second patient with three SNP differences between the genomes of isolates collected 5 months apart. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We previously showed that ANP prevents the incidence of postoperative complications after lung cancer surgery (10–12). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Although MCP-1 −2518 A/G has been the most commonly investigated MCP-1 SNP, there are other SNPs located in the MCP-1 gene [12]. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In accordance with current European and American guidance (Center for Drug Evaluation and Research, 1978; Committee for Proprietary Medical Products, 2002), the use of relapse and recurrence rates as primary outcome measures in continuation treatment and long-term trials is recommended, albeit without providing an operational definition of relapse and recurrence with respect to psychiatric scales or other diagnostic criteria. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Theophylline inhibits renal vasoconstriction thus increasing renal oxygen supply. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Thus, as policymakers place more emphasis on the effectiveness of individual teachers and the longterm benefits of effective teaching (Chetty et al., 2012; Konstantopoulos & Chung, 2011), it is clear that what teachers do in the classroom, their use of evidence-based instruction, their ability to differentiate this instruction, and the training and professional development they receive all make a difference in student learning and, hence, in teachers’ value-added scores. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Conversely, inclusion of a morphomic estimate of skeletal muscle area to the Cockcroft-Gault scaffold [(140 − age)/SCr], as a replacement covariate for weight and sex, nearly doubled the amount of variability explained by the model. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Since cognitive function was assessed in the ARIC study in midlife in individuals without dementia, it is possible that the relationship between the MS4A4E SNP and AD, and the polymorphism and cognitive change may actually be different. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Since 2014, the ERAS protocol has been a mainstay of perioperative care in our center regardless of the type of surgery performed. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, generalizing the null results of our study in an middle-aged and older Chinese population to other populations is cautioned, since subjects with middle-age and older have been shown to have more opportunities in taking daytime napping26. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In addition, the duration of the intervention was short and the navigator worked part-time. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | If the lost neurons had contained this type of repository, and if it the term ‘amodal’ is interpreted to designate a domain-independent integration of semantic information, non-verbal and verbal object representations would have been expected to display comparable impairments. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our study results show that the risk of having atopic dermatitis and severe condition increased with higher maternal educational levels in girls and with higher paternal educational levels in both boys and girls. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, ancillary moderation analyses showed that the relationship between prayer and pain severity as well as between prayer and pain tolerance is depending on the religiosity of the pain patient. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In contrast, several studies reported that lutein/zeaxanthin intake was not associated with CRC risk. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The concept has been articulated most succinctly in the following words: ‘… the neural network for semantic memory requires a single convergence zone or hub that supports the interactive activation of representations in all modalities, for all semantic categories … damage to the hub should produce a semantic impairment that is independent of the modality of input (objects, pictures, words, sounds, tastes and so on) and of the modality of output (for example, naming an object, drawing it or using it correctly)’ (Patterson et al, 2007). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This result implies that big cities may have more sources of pollution that stimulate the autoimmune system [39]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our study shows how much crematoria staff rely on accurate and complete cremation forms. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Because the physiological immune response of circulating leukocytes to systemic inflammation is accompanied by increased neutrophils and decreased lymphocytes, the NLR has been proposed as a simple parameter of systemic inflammation and stress in various diseases [13]–[15]. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The analysis neither supports nor invalidates the use of neuropsychological tests in TBI, but rather reflects the failure of progesterone to improve outcome in this cohort of subjects with moderate to severe TBI. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Although inflammation existed around the cervix after conization, it has been reported that radical hysterectomy could be performed at any time after conization [15], which might be due to the excision of inflammatory organization around the cervix in radical hysterectomy, indicating that greater post-hysterectomy infection was affected by the inflammatory organization around the cervix. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Because most public mental health care systems are not integrated with general medical care, future research could examine HCV screening and prevalence among people with SMI within an electronically integrated health care system that includes all laboratory tests and results (e.g., Kaiser Permanente). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Osteomalacia may occur without clinical or biochemical abnormalities and in the absence of steatorrhoea. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Both the aging and 6-OHDA parkinsonian rat models manifested changes to the orophargyngeal swallow and these changes were identified by videofluorography. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In summary, the results of this study appear to support the role of sleep habits as a fundamental determinant of the elevated risk of stroke in southern China. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Second, the assessment of prenatal predictors of BMIz trajectories may enhance our understanding of etiologic pathways of cardio-metabolic disease. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | More work is needed to establish the optimal “pass” and “refer” criteria ideal for use in Hawai‘i's pre-school children. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Thus, using measures that reflect parameters that are typical of rat bolus procurement and swallowing, we discovered that both aged and parkinsonian rats display oral and pharyngeal deficits and thus present a good model for use in studies aimed at uncovering biological correlates of dysphagia in these disease/disorder groups. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The Lasso logistic model has been used in variable selection in many fields as it can effectively exclude some irrelevant variables and produce sparse estimations and good asymptotic properties34, but this study was the first to apply Lasso in the identification of the most important risk factors that contribute to elevated stroke risk in a case-control design. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | These results might be attributed to differences in the range of lutein/zeaxanthin intake, CRC status and the point that CRC examination began in the cohort study. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Another limitation of our study is the absence of biomarkers other than serum creatinine in order to detect CIN. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In the United States (U.S.), two studies of university students indicated that the farther the distance or the longer the commuting times between home and university, the lower the likelihood was of choosing to use an active commuting mode [63,64]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The patient P9 could possibly be linked to this outbreak via hospital H. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | To better understand the contribution of mitotic genes to cancer predisposition we investigated whether inherited genetic variation in mitotic genes contributes to the development of breast cancer. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In cases of severe renal insufficiency, unfractionated heparin should be administered. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Additionally, non-invasive measures including PWVcf, carotid wall echodensity and ICA flow velocity offer quantitative insights into accelerated vasculopathy in HGPS, and may provide sensitive indicators of disease progression or remission with adjuvant therapies. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Reports of the success of preemptive gabapentin treatment have been mixed (Adam, Menigaux, Sessler, & Chauvin, 2006; Dahl, Mathiesen, & Moiniche, 2004), and further studies are warranted. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | While meta-analyses have suggested that breastfeeding is associated with a reduced risk of childhood overweight and obesity, this evidence is largely based on observational studies; reverse causality and residual confounding by behavioral or socio-economic attributes may explain the results of those studies. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our results also converge with a growing body of research on the physiological processes of inflammation that call in question previous formulations of energy balance. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Since CPB gas and blood flow conditions are often very unstable for an unknown length of time after the start of bypass, during which period it is not possible to calibrate the CDI with a reliable result, we recommend gas calibration of the CDI 500 prior to use. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In the present study, the GRS63 was clearly associated with cross sectional BMD, but not with BMD change. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | While small numbers of patients enrolled in this pilot study preclude definitive conclusions, there is evidence to suggest that patient navigation may be an effective intervention. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Albeit imperfect, an appropriate animal model can provide critical insights into putative mechanisms underlying health and disease in humans, and is in fact, one of the only ways to do so. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Levels of plasma D-dimers should be determined in symptomatic patients with confirmed SARS-CoV-2 infection. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our findings seem to support our hypotheses. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In this article, AKT1 rs1130214, rs2494732, rs3803300 polymorphisms were analyzed the association with the onset risk of CHD. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Significant clinical improvement was delayed and took up to 2 years for complete radiological resolution of the nodules in some patients. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In our cohort, HIV-1 RNA levels in blood plasma were approximately 30-fold higher than in seminal plasma. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The safety of both regimens was ascertained, as no local reaction over 0·5 cm nor systemic reactions were registered after 650 administered doses. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This could be some level of stress as consequence of the nest disruption. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | There is now substantial experience with vision screening utilizing a photoscreener nationally and internationally including large screening programs of preschool children numbering in the hundreds of thousands.7–11 Experiences specifically with Plusoptix have also been published 12–16. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | At St. Jude, physical rehabilitation may require as long as 6 months, even in the absence of postoperative complications or re-interventions. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | These genotyping goals were not met during the study despite repeated search method education sessions and encouragement throughout the trial period. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The disease-specific inclusion criteria define a population of mildly to moderately depressed patients and thus reflect the clinical group in which Hypericum extract is predominantly used and in which most of the trials investigating the drug’s efficacy in acute treatment have been performed. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | (K. Lasser, et al, 2011) While Lubetkin et al (Lubetkin, Lu, Krebs, Yeung, & Ostroff, 2010) have shown that PCPs serving low-income, racial and ethnic minority patients are interested in providing tobacco-related patient navigation services at their practices, we are unaware of prior studies that have examined the acceptability and feasibility of patient navigation for smoking cessation in practice. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This comparison showed higher scores among the non-eligible individuals for two clinical scales: Hysteria and Schizophrenia. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Since 1995 there have been sustained and systematic efforts to improve control of BP and other major risk factors in adults with diabetes. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Since aneuploidy and chromosomal instability are commonly observed in human cancers, further investigation of the influence of inherited variation in mitotic genes on tumor grade and cancer risk in additional studies of both breast cancer and other cancer types is merited. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Neither of our study groups was superior in terms of complications. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The reliability and validity of the questionnaire data were assessed by previous studies [31], [32]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, the approach allows only suggestive conclusions of whether or not the intervention was effective or not within each subgroup (“absolute effectiveness”). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | As shown by Maskell and coworkers,34 dizziness, along with anxiety and depression, commonly has a profound impact on quality of life. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In vivo, the response of these cells could be partially different because of the presence of multiple different cell types, cell-cell interactions, extracellular matrix interactions, and the physiological context. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Limitation of our study was possible interaction with other polymorphism may affect our results. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The same study also showed that, although the primary complaint of 68% of the patients was the mass in their breasts, only 29.7% of them were performing BSE regularly (Bayer., 2014). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | TLRs 2–5, 7, 9 and 10 are expressed in melanocytes (50). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Third, deleting Dicer reduces T-reg cell numbers and immune pathology, indicating Dicer’s importance in immune regulation and immune cell development72,73. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The AAP, AACO, AAPOS, and AAO disagree, citing studies showing increased benefit from detection and treatment of amblyopia earlier than age 3 30. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Patients with IBS-D had accelerated colonic transit compared with healthy controls examined with the same method that has been established in our laboratory for over 20 years. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In a subgroup analysis, we evaluated whether this also affects the gut microbiome. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Researchers recommended that this inverse relationship calls for a need-based framework for understanding active commuting in LMICs, versus the more common choice-based framework [50]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In contrast to what Geddes and colleagues (2003) have observed for most of the studies included in their review, our trial provides a clear distinction between continuation and maintenance treatment, and thus also between relapse and recurrence. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Nevertheless, the enforced expression of NPM/ALK on the LAMA-84 cells led to an increase in the methylation of BIM 5′UTR (Figures 6, E and F, and W5) and to the stabilization of a specific methylation pattern (Figure 6E). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | These observations are also in line with the previous findings [6,7,9,10,11,12]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Common measures in videofluorography of humans to capture these deficits include number of swallows per bolus, festinated tongue movement, range of tongue movement, oral residue, and premature loss of bolus to pharynx, and disordered jaw movements for mastication and bolus transport [50] [11, 16-18, 35]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Both instruments thus give the blood gas results at 37°C values. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Interestingly, we found no evidence for catch-up growth in the present sample (i.e., child HAZ did not predict subsequent growth in any model). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Honsawek et al. investigated MMP-3-1612 5A/6A gene polymorphism with knee osteoarthritis in Thai population and indicated that the -1612 5A/6A polymorphism genotypes of MMP-3 gene promoter do not play a role in the development of osteoarthritis in the Thai population [2]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Specifically, heavy cannabis users trying to change make multiple, unplanned and short-lived attempts to change and even short periods of cannabis abstinence precipitate withdrawal symptoms but do not appear to increase alcohol and tobacco use. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | A number of clinical studies have been initiated to answer important questions such as the following: Is very early prophylactic anticoagulation beneficial with regard to prevention of VTE and other relevant endpoints, e.g., hospitalization, need for ICU admission, mortality? |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Genes involved in the control of the progression of the cell cycle from G1 to S phase that have been reported to be mutated in melanoma include TP53, CDKN1A, CDKN2A and CDKN2B. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In summary, our study identifies novel putative melanoma susceptibility genes and provides insight into the biological implications of significant gene associations in melanoma. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Regarding PO10-4 and PO10-5, no epidemiological link could be made between the patients within the possible outbreaks. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The mechanism of development of bone pathology in patients with untreated coeliac disease is not fully defined, but chronic negative calcium balance16 caused by loss of villous surface area,17 binding of calcium to fatty acids in the intestinal lumen,18 and impairment of active intestinal calcium transport mechanisms because of depletion of calbindin from the enterocyte19 are all potential factors. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This result is consistent with the European consensus, which emphasizes the importance of achieving R0‐resection, either initially or after induction treatment for both metastatic disease and primary tumor after a multidisciplinary team discussion 6, 9, 23. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, carbapenemase genes are often located on mobile genetic elements (13, 14), together with other resistance genes encoding resistance to antibiotic classes commonly used in veterinary medicine (e.g., tetracycline, sulfonamides, or phenicols). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Given the multiple comparisons in the locus by locus analyses in the Illumina dataset, one cannot rule out the possibility that this finding is the result of chance, and given that the independent sample set did not replicate this finding using an alternative method, we conclude that it is likely to be a false positive association. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This study compared psychological test data obtained from individuals approved for gender reassignment procedure with test data obtained from individuals who were rejected. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Despite an adequate methodical approach, the present study did not reveal an association between MCP-1 −2518 A/G single nucleotide polymorphism and systemic sclerosis in Slovak population. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Additionally, our study indicated that age is a risk factor for hypertension in residents of Xinjiang, which is also in line with reports from global epidemiological research, as the risk of hypertension increases with age [25,26]. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We concluded that presence of unrelated atypical serum immunofixation patterns could be a possible laboratory marker of good prognosis in MM patients after ACST. |