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This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The prospective surveillance data here indicate that there have been three widespread seasons of EV-D68 in Wales since 2015, lasting from 10 to 25 weeks. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Two gene pairs can predict which men would experience progression to the metastatic form of the disease. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | First of all, current analysis failed to focus on information from diet such as salt intake, which was associated factors of hypertension. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | A drawback of previous studies is the utilization of BMI at a single time-point as a predictor of subsequent obesity and cardiovascular risk4, 5. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Of these, 20 variants in 12 genes demonstrated larger effects in high grade cancer and an additional 24 variants in 17 genes were not associated with risk of overall disease. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | For example, if the number of samples in each of two groups is 10 and the number of probes is ~10 000, the expected number of perfect classifiers that can appear by chance is 47.6=C210000220. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The observed and expected frequencies of these genotypes were similar, indicating that SLC4A1Δ27 and GYPCΔex3 are independently distributed as would be expected under Mendel’s law of independent assortment. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Indeed, evidence shows that humans and other animals use alternative ways that have lower computational complexities than explicit search. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This strategy may enhance newborn care by reducing the time to adequate antibiotic therapy. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In this regard, German study recruited SSc patients presenting with skin involvement while affection of other internal organs was not reported here [13] by contrast to our Slovak patients. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In the present disorder, however, the stimulation-dependent decrement of the CMAP is not owing to impaired resynthesis of acetylcholine and concomitant abnormal decrease of the EPP, but stems from a defect in Nav1.4. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, there are few epidemiological studies on hypertension, awareness, and hypertension associated factors. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Another study reported that local surgical therapies for metastases, including hepatic arterial infusion, radioembolization, and transcatheter arterial chemoembolization affected the survival of the metastatic CRC patients 7, 24. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In healthy adults, bacterial clusters within the phyla Bacteroidetes and Firmicutes usually dominate the intestinal microbiota, whereas the proportions of Actinobacteria, Proteobacteria and Verrucomicrobia are relatively small [17]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Nevertheless, there is a scarcity of literature revealing such relationships in children born healthy and full-term. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Alternatively, the straw board could have been contaminated after manufacture by the feces, urine, birth products, or a corpse of an infected rodent that gained access to the inner layer of a straw board. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | A number of studies, primarily conducted in rats with experimentally induced TBI, have demonstrated beneficial effects of progesterone on measures of working memory, spatial navigation, avoidance learning, and motor performance (see Deutsch and coworkers24 for a review). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Therefore the vibrating sandals may have achieved half of the effect required to reduce onset of mobility disability. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The data available for our research limited our ability to determine whether attributes other than density and distance, for instance the quality of resources, the average price for healthy and unhealthy food, or mobility (e.g., access to a car) (Sharkey et al, 2010a), could influence cardiovascular risk. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | A retrospective study reporting typing results for 2,770 enterovirus samples submitted to the Public Health England Virus Reference Department during 2004–11, indicated that EV-D68 was only detected in 14 of 1,875 typed samples [10]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The comparative strength and limitations of the LCGMM method over other alternative approaches (e.g., tracing growth on a growth chart) are the subject of some debate37. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Future Directions Despite finding positive tolerance outcomes, it is still unclear how specifically tolerance may develop and what specific psychological mediators led to these reductions within an Oxford House. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Because we focused on only E-selectin expressions in this study, further studies are necessary to elucidate the detailed mechanism and role of the ANP–GC-A system in cancer metastasis. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | SLC4A1Δ27 is considered to be a balanced polymorphism, where the selective advantage against severe malaria for heterozygotes outweighs the disadvantage of lethality in homozygous persons at the population level [12,13]. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Therefore, our results may provide very valuable information for excess weight loss is a critical public health priority in prevention of hypertension in Xinjiang residents. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our long-term goal is to connect stress mediated changes in cortical morphology to specific molecular mechanisms involved in neuronal network formation and modulation. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | RTX has been shown to be equally effective in treatment of ANCA negative GPA, suggesting that its effects are mediated in part via immune mechanisms distinct from autoantibody production. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | It has been used successfully in the treatment of phantom limb pain in adults (Bone, Critchley, & Buggy, 2002), children and adolescents (Bone, Critchley, & Buggy, 2002; Rusy, Troshynski, & Weisman, 2001) and for cancer-related NP in adults (Caraceni et al., 2004) and children (Jacob, 2004). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | One of the claims for modified allergens is to retain immunogenicity, and several studies have demonstrated that extract modification does not impair the therapeutic efficacy of the allergen extracts. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | It was shown that keeping a nasogastric tube does not help in the reduction of the number of complications, but it slows peristalsis return, increases the number of respiratory complications, and prolongs LOS [29–31]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | A limitation of the study is that the presence of attenuation artifacts could not be confirmed by the absence of any coronary stenosis at angiography. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Rinaudo and Schultz [17] compared global patterns of gene expression in preimplantation mouse embryos derived from culture in 20% oxygen with that of 5% oxygen using the Affymetrix MOE430 chip. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Therefore, due to the cost, possible side effects, and the limited saving of homologous blood, intraoperative antifibrinolytic therapy may not be indicated in routine cardiac surgery. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Estrada et al reported an odds ratio of ≅1.6 for those in the group with the highest risk score (9% of the population) compared to those in the middle group (34% of the population). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | It is possible that epigenetic (60) and gut microbial (61) changes triggered by early-life inflammation moderate this pathway. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Others report only severe complications, frequently ignoring those complications that did not require intervention. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Fentanyl doses should not exceed 0.5 to 1 mcg/kg/hr in order to minimize the risk of pruritus (Desparmet, Hardart, & Yaster, 2003), respiratory depression, and sedation. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We characterized this single gene disorder as a disease of vascular stiffening in the setting of gradual vascular stenosis, much like that seen over a lifetime in normative aging This study’s human clinical investigations help us to translate the in vitro7, 9, 27, 28, 33, mouse model9, and human pathologic4, 26 support for key roles of altered lamin A and progerin in human aging. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The original article by Wayne Bolton in 1958 studied a sample of 55 females with excellent occlusion to detect the ratio of tooth size discrepancy 16,27. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Using ChIP experiments, we demonstrated the involvement of histone H3 tail deacetylation, a well-known marker of chromatin condensation [50], in BIM silencing (Figure 4, A and B). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, convenience sampling is a common practice in HIV research, and it would be difficult to obtain a truly representative sample because of stigma related to the disease. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This may account for the greater treatment effect in patients without diabetes. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The present study showed that an increased NLR is an appropriate indicator for prenatal diagnosis of HCA. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | 5 Studies using viscoelastic whole blood assays have demonstrated significant hypercoagulability due to a severe inflammatory state in COVID-19 patients requiring ICU admission, 31 32 further arguing against DIC as a universal finding in advanced disease stages. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Echodensity in the HGPS cohort often saturated the upper limit of detection; technical expansion of the 256 gray scale would allow additional density capture. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Contaminated fomites can produce secondary aerosols of C. burnetii sporelike forms (4), and several outbreaks have demonstrated the possibility of spread on fomites such as clothing, straw, hay, contaminated shoes, and building materials (22,25–36). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This study does not capture those febrile illnesses that did not lead to hospitalization—either because adequate care was obtained elsewhere, or because barriers to hospital care were insurmountable. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Paracetamol decreases acute dental pain [24] and is commonly used by patients who have dental pain [25–27]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Most transaminase elevations improved to grade 1 or to pre-retreatment levels within 15 days, and less than 2% of cycles had recovering times longer than 25 days. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We observed that opioid-related complications did not significantly differ between LPN and RAPN. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This study has brought forth important findings that may contribute to improving the health of Nepalese adolescents. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In a pooled analysis of cohort studies, dietary lutein/zeaxanthin intake was associated with a slightly reduced CRC risk24, and a similar association was found for the risk of colorectal adenomas in a cohort of male health professionals25. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The main finding of this study was that transsexual individuals present profiles that are relatively free of psychopathology. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Liver tests abnormalities, defined as grade 3/4 transaminase elevations, are common events during treatment with trabectedin. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Some authors have suggested that the MMPI scores of transsexual individuals should be interpreted using the normative data for the subject’s gender identity5,28,36. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The very high (>95%) response to the booster dose is reassuring in the case of professional exposure to wild-type HBV, even in professionals with non-protective HBsAg antibody titers at the time of the accident 23. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In Estonian and Croatian HIV patients, ARV treatment did not appear to have an effect on QoL. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | At last followup, the incidence of thigh pain was 0.8%. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In a further analysis of the prognostic value of the cellular subpopulation of CTCs, we found that CRC patients with high expression of CD133+CD54+ (P < 0.001), CD133−CD54+ (P = 0.004), and CD133+CD44+CD54+ (P = 0.003) subpopulations of CTCs had a worse survival than those with low expression. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The stress paradigm used by Bock and colleagues is closely comparable to our stress protocol. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Transport industry workplaces, including truck cabs, truck depots and truck stops, are increasingly recognized as settings conducive to health promotion 3. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Curve slopes for both extracts were not significantly different, indicating that there were no changes at IgE epitopes due to the chemical modification. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Early surgery with standardized antibiotic therapy may be necessary for patients who are likely to fail medical therapy yet have sufficient predicted postoperative pulmonary function. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, the Infinium HumanMethylation 450 BeadChip, due to its probe design, does not interrogate repetitive elements which are found to be differentially methylated in many cases of neoplasia [28], [29]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The differential condition effects maintained though the regression analyses even when controlling for socially desirable responding. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Furthermore, since we used a single blood sample to calculate NLR, it is uncertain whether a single sample could reflect an elevated NLR over time. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | If (b) is answered in the negative, the medical referee may, under Regulation 12 of the Cremation Regulations (1930), prevent cremation4. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We found no such overestimation in our study. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We determined the incidence of CIN using a common definition (raise in serum creatinine of ≥25% and/or ≥0.5 mg/dL), that has been validated in many studies. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The postoperative period often coincides with an intensive physical rehabilitation program (continuous passive movement, strengthening and stretching, assisted ambulation) that requires ongoing pain interventions. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Culturing embryos in low oxygen concentration improves embryo utilization rate and increases the chance of pregnancy. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | It should be considered that COVID-19 patients may be immobile for a while before hospitalization. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In the case of significantly elevated D-dimer levels (≥1.5–2.0 mg/L), pharmacological VTE prophylaxis should be initiated and hospitalization be considered, regardless of the severity of clinical symptoms. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Thus, it is apparent that the incidence and prevalence of bone metastases are difficult to determine with accuracy, and there are no studies concerning the incidence of bone metastasis as the first sign of generalised metastatic disease. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In conclusion, there are disturbingly low rates of HCV screening among a high-risk SMI population. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Solid cathode, liquid electrolyte systems such as the lithium/carbon monofluoride and lithium/manganese dioxide pacemakers have greater gravimetric energy density (watt h/mm3) and are therefore likely to be future cardiac pacemaker power sources10. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The motivation is increased stimulated surveillance in next step for the development of kidney disease. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | A possible limitation of the present study was the sample size. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | First, the coordinates of food vendors were obtained in 2016, which was four years after the third follow-up data collection in APCAPS. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This was done by using the robust Illumina technology. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We were also cognizant of the importance of noting the reasons why a particular test could not be administered. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Only some authors use Clavien-Dindo classification. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In general, microorganisms can activate monocytes, tissue macrophages, and endothelial cells, thus triggering the production of proinflammatory cytokines and activation of the coagulation protease cascade. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our data indicate that TNF but not TNFR1 or TNFR2 causes podocyte apoptosis (Figure 3G). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The results, furthermore, might indicate that prayer has a positive relationship with pain tolerance for CP patients. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our study has several important limitations. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In contrast, no relationship was observed between the ratio of Bacteroidetes and Firmicutes and diets low in carbohydrates [26]. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In particular, we make the following observations and recommendations: Cohort Selection Ascertainment according to broad criteria can give only limited enrichment of rare variants. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In addition, using high-quality data obtained in a systematic and standardized approach, hypertension was used to construct a prediction model for the multiple ethnicity population, as similar studies have not been reported. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Any model, in the best of circumstances, can only serve as an approximation to the human clinical situation it is designed to reflect. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Further risk factors such as advanced age, comorbidities, and history of VTE may result in thromboembolic complications even after successful treatment of the SARS-CoV-2 infection and discharge from hospital. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | First of all, given the cross-sectional design of the study, we could not demonstrate temporality of the associations observed. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Additionally, in a study of oxandrolone's effects on adult tetraplegia patients, Spungen et al found a significant combined improvement in measures of spirometry [17]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | It is widely accepted that development is plastic and the sensitivity of the epigenetic system to environmental factors is heightened during periods of developmental plasticity such as childhood, adolescence and puberty [17]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In this study, for example, one patient had a positive C. trachomatis IgM of 1:40, and an elevated C. pneumoniae IgG titer of 1:256 (Table (Table2).2). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In contrast to CVID patients, IPH and IgGSD patients did not have significant alterations in mean cTfh cell levels, in mean chemokine receptor expression on B and T cells, or in mean ICOS upregulation on activated T cells. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Finally, the possibility that other local factors contribute to TNF pathway activation in podocytes exposed to patient sera should also be considered. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Such experiments could test the effect of variables like the mean and the variance of cached values on the probability of expanding a node. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In the meantime, Kim et al. reported a 10% complication rate in their group [38]. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Excess weight loss is a vital strategy for controlling hypertension, particularly if accompanied with other preventive measures. |