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This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We can hypothesize that transsexual individuals without hormone therapy tend to be centred on their own difficulties, depressed, and uncomfortable with other people. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Pre-implantation knowledge of the venous anatomy may help determine whether transvenous left ventricular lead placement for CRT is feasible. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Further, the study sample was drawn from only four secondary schools of Birgunj, which could limit the generalisability of the results in different settings. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | While eating walnuts, subjects were instructed to either reduce fat, carbohydrates or both. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This observation can be partly explained by an upward LV displacement, as previously documented for prone comparatively to supine positions (24). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Bedaiwy reported that high ROS levels on day 1 in the culture media are associated with a low fertilization rate, low cleavage rate, and high embryonic fragmentation during ICSI cycles [14]. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | All hospitalized COVID-19 patients should receive pharmacological VTE prophylaxis in the absence of contraindications. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Additional investigation will be required to elucidate the extent to which observed sex differences in cortisol feedback modulate an individual's response to classical stressors (24). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The goal of this investigation was to explore the spared and impaired aspects of word and object knowledge associated with this relatively focal neuronal loss at the tip of the left temporal lobe. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Yet, we hypothesized that the GRS63 might capture more of the variation in BMD and thereby more of the fracture risk than the subset of SNPs included in the GRS16, and, therefore, we compared the performance of these two genetic risk scores. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This would indicate that regardless of treatment, bone metastases will appear in a certain number of patients. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In a recent study by O’Sullivan et al (2018) found that 38% of overdose patients treated in accident and emergency departments are caused by dental pain [25]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Aminoglycosides serve as a benchmark class for the principle of dosing antibiotics based on body size and renal function, though the choice of the right scalar of weight to use in these calculations has been debated. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Since randomization is performed only at the beginning of the study period to which it applies, the validity of the treatment comparison for a specific phase is not compromised by selection bias resulting from the outcome of the preceding period (Möller, 1986; Montgomery, Kasper, 1998). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Although NP is not uncommon in cancer patients, only a small number of clinical research trials have specifically assessed analgesic drugs for cancer patients with NP (Caraceni et al., 2004; Mercadante, Arcuri, Tirelli, Villari, & Casuccio, 2002). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Namely, a sequential decision-making task has demonstrated that humans use strategies such as ‘fragmentation’ and ‘hoarding’, in addition to pruning, for efficient planning. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | To date, several molecular genetic studies have implicated a number of genetic variants in hepatitis-related LC including two GWASs, each of which revealed two independent susceptibility loci for LC20,21. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In fact, while reduced ABCA1 expression alone is not sufficient to cause podocyte injury, simultaneous pharmacological inhibition of the conversion of free cholesterol to esterified cholesterol in ABCA1 knockdown podocytes was sufficient to cause cell injury (Figure 5). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In the present study, we demonstrated that postoperative infections following hysterectomy performed within 2 weeks after conization were more common and severe than those occurring following procedures conducted 3–6 weeks after conization. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The time during which hysterectomy could feasibly be performed after prior cervical conization has not yet been determined. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The finding that the CS ostium is ovally shaped agrees with observations in other cardiac veins [4, 5, 9]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Mechanisms Accounting for Reduced Availability of Functional NaV1.4. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This regime in combination with bicarbonate and theophylline could be a promising way to further reduce the incidence of CIN and should be investigated in randomized trials. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Patients may be more apt to believe a navigator they have come to trust, who communicates in a culturally sensitive and accessible fashion. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Simple steps such as the duplication of the two statutory questions on form B to the coroner's form E, along with a question about implantable devices on the relatives' form A, might help reduce the number of explosions in crematoria. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our findings are consistent with other studies investigating the effect of a walnut-enriched diet on the gut microbiome (consumption of 42 g/day walnuts over a period of three weeks) indicating a significant (p < 0.05) increase in the relative abundance within the Clostridiales order. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, as poverty and health disparity in perinatal determinants of health are both recognized problems facing the Native Hawaiian community,28,29 it would not be surprising to find that Native Hawaiian children may also be at risk for under-diagnosis and under-treatment of vision disorders. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The MMPI-2 is one of the best standardized methods for assessing the psychopathological profile of adult populations aged 18 years and over, including transsexual individuals5,36,53,54. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The incidence of CIN in group S (9.0%) is in line with the incidence of CIN in patients who received theophylline in the recent meta-analysis of Dai et al7 (7.9%). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Alternatively, given the multi-factorial nature of falls, a change in gait variability alone may not be able to overcome the effect of other pathologies or risk factors. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our findings suggest that, in addition to the energetic demands of developing a large and complex brain (12), immune activity considerably constrains the energy available for childhood growth (14). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Despite their improved performance characteristics, cardiac CZT cameras are still considered to provide suboptimal specificity for identifying significant coronary artery disease (23), and attenuation artifacts potentially play a substantial role in this setting. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Environmental and epidemiologic evidence suggests that this outbreak was associated with the renovation of an office block within a cardboard manufacturing plant. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | There are many issues that remain to be addressed when seeking to identify GSVs that are associated with complex disease, several of which are highlighted by this study; some of these issues are also relevant to the analysis of rare variants identified by sequencing approaches [31], [32]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | At the point of arrival at the referral hospital, a majority of households had already extended beyond their savings to pay for medical care, incurred debts that would require repayment, and reached the point of catastrophic expenditure. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | These benefits include faster gastrointestinal recovery, decreased postoperative nausea and vomiting, and improved wound healing. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Second, to make the data of this study comparable to previous and future trials on prevention of CIN, we chose the most frequently used definition of CIN. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This finding replicates other single-grade studies but with a different population of students and teachers and with a control group that received the same amount of professional development, albeit in mathematics. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | A strength of this study is that we performed a comprehensive evaluation of variation in mitotic genes and risk of breast cancer. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Therefore, our findings reinforce the need to take into account measures of emotional status when investigating subjective symptoms and their relationship with objective balance measures in TBI. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Implications for the Etiology of Growth Faltering. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This does not imply that there could be no other clinically signifi cant differences than those investigated in our study. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Patients randomized to WS® 5570 receive the same dose during long-term treatment as well. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Using a similar comparison but for incident fractures, we found in the present study an HR of ≅1.4 and ≅1.2 for GRS63 and GRS16, respectively for those in the group with the highest risk score compared to those in the middle group. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This finding can be explained by the potential antioxidant activity of the cumulus cell mass and normal spermatozoa present inconventional IVF cycles. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Instead of applying commonly used measures of the human swallow, which don’t directly translate to the rat, we focused on more specific measures of rat deglutition. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Finally, the association between genetic variants in CLU (rs11136000), CR1 (rs6656401 and rs3818361), and PICALM (rs3851179) and several tests of memory was analyzed cross-sectionally in 2 groups of 268 African-Americans and 2,651 whites that included both AD cases and controls. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The fallers showed greater variability than the non-fallers suggesting that variability may be associated with falls. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Engagement initiatives should offer education on the recognition of warning signs (such as reduced level of consciousness) that should prompt a provider to refer a patient to a qualified doctor or hospital. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | These results indicate that the combination of CRP level and NLR may help to improve prognostic accuracy in patients with PIR. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Third, mindfulness could change by training on meditation and previous exposure [9; 30], which has not been assessed in this study. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Many of the group and interactive factors establish a set of new setting norms and reinforce super-ordinate goals, such as overcoming substance abuse, even if residents share only minimal other preexisting characteristics. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This supports the finding of Othman and Harradine,29 O’Mahony et al,30 and Asiry and Hashim31 in the Saudi sample, in which they found no significant gender dimorphism on Bolton’s ratio. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Comparable results could be observed in a trial in rats showing significantly greater species diversity after ten weeks on walnut diet by increasing the abundance of probiotic-type bacteria including Lactobacillus spp., Ruminococcus spp. and Roseburia spp. [34]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We were also unable to account for childhood dietary patterns or physical activity at 5 years, which may reflect exposure to an obesogenic environment. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | International collaboration is needed for a better understanding of the temporal and geographical pattern of circulation. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | C. trachomatis IgM antibodies by MIF testing appear to be less heterologous than IgG antibodies, and are observed after primary but not repeat exposure to C. trachomatis 1. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Of 3 GSVs present in >0.1% of subjects, 2 showed association with changes in BMI at or near nominal significance. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | These data indicated that Korean adolescents' smoking rate was relatively low among OECD countries. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This supports that circulating TNFR1/TNFR2 may represent a compensatory mechanism to elevated local TNF. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Several mechanisms of BIM regulation have been described both at the transcriptional and posttranscriptional levels [20,39–44]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The clinical benefits of immunotherapy can be achieved more rapidly, safely and with fewer injections by use of polymerized pollen allergens instead of the conventional native extracts. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Inaccurate verbal definitions of words provide reasonably reliable indicators of impaired word knowledge because the input and output stages of the task are both confined to the language network. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Several studies have been published in which EIT was used to assess mechanical ventilation in intubated patients 21–23. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The first laparoscopic total gastrectomy was successfully performed by Azagra et al. in 1993 [17]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Furthermore, for this group of religious affiliated patients high levels of prayer were also related with more pain tolerance. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This study demonstrates that glutaraldehyde-polymerized allergen extracts of P. judaica used in accelerated schedules are safe to treat P. judaica-allergic patients, inducing blocking antibodies and reducing levels of specific IgE to a major allergen. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The measures of heightened cortisol feedback included ACTH secretory-burst mass, pulsatile, basal, and total ACTH secretion, as well as ACTH ApEn. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | It has been stated that most metastases occur approximately 1 year after diagnosis [3] and that the most common site of bone metastases is the vertebrae [5]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | A recent systemic review suggested that arterial hyperoxia was associated with poor hospital outcomes[Citation]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | A recent meta-analysis focusing on patients with renal impairment was able to show a benefit for bicarbonate 15. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Body weight was only a marginal factor in this estimate, as CrCL determined without using weight still explained 21% of the variability in this parameter. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In fact, Bongartz and colleagues outlined the four major cardiorenal connectors: increased activity of rennin-angiotensin system, oxidative stress, high activity of the sympathetic nervous system, and, in particular, inflammation and cytokines [23]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | With an expected KIR Best frequency of 11, KIR Better 20% and the remainder being KIR Neutral, selection of fewer than 4 donors per search would hamstring the likelihood of identifying a KIR Best or Better donor beyond those available in the random population. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This finding highlights the primary function of body fat in meeting energy shortfalls among humans (citation). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Moreover, Lee et al reported that there were no differences in postoperative opioid consumptions and pain intensities during the first 24 h in patients undergoing isoflurane anesthesia with 70% nitrous oxide or with 0.17 μg/kg/min remifentanil infusion for open colorectal surgery18. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | A recent systematic review pointed out that relatively few studies have analyzed outcomes by patient baseline variables[citation]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Recent experimental reports demonstrated that inflammatory chemokines including chemokine ligand (CCL) 2 and CCL5 contributed to not only leukocyte recruitment but also tumor cell homing to activated endothelial cells (33, 34). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In our study, bone metastases occurred approximately 17 months after initial diagnosis of the solid tumours, and the majority of bone metastases were in the lumbar spine (Table 2). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The same view can be also put forward in the present study. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, during cremation, when temperatures reach 1300 °C (2400 °F) for 90 minutes, iodine forms a gas that rapidly expands, causing the pacemaker casing to burst. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | A growing body of evidence has indicated that the up- and downregulation of DICER1 are related to the development of tumorigeneses such as lung, breast, ovarian, skin, prostate cancers, and CRC via the alteration of miRNA expression17,20,50. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The one patient with prominent impairments in both grammaticality and repetition, Patient S5, was also the only subject to display a small, but significant, patch of additional atrophy in the temporoparietal junction, including the posterior tip of the superior temporal gyrus. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Here we demonstrate that cancer recurrence after curative surgery was significantly lower in ANP-treated patients than in control patients, suggesting that ANP could potentially be used to prevent cancer recurrence after surgery. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Whether progression of initial coagulation changes to SIC or DIC is a characteristic feature of COVID-19 and not caused, e.g., by ARDS, septic shock, or ECMO therapy is currently not clear. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Cluster XIVa) and are highly abundant within the human microbiome. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Although HCA and amniotic fluid culture tests are useful in diagnosing intrauterine inflammation and predicting the prognosis of a neonate, they have drawbacks, such as the time needed for culture and the high possibility of a false negative result due to various causes. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Some limitations of this study must be mentioned. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, the questions we used for self-reported stress level are standard, and similar questions have been used in other studies such as a Canadian nationwide health survey where self-perceived stress level was assessed by choosing among the five categories: (1) not at all, (2) not very stressful, (3) a bit, (4) quite a bit, and (5) extremely stressful [48]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Perspectives The HGPS vascular phenotype is associated with significant premature cardiovascular morbidity and mortality occurring in the absence the common comorbidities that are prevalent in adult populations, such as smoking, hypercholesterolemia and obesity. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The choice of the correct model and number of classes in LCGMM is also not always straightforward. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Trabectedin treatment has shown to be reasonably well tolerated during its phase II and III clinical development. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Type of glucocorticoid may be relevant, given protein-binding, kinetic, and brain-uptake differences between synthetic and natural glucocorticoids (7, 12, 22). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | If age at menarche is related to methylation patterns in these repetitive elements, the hypomethylation would not have been evident in the 450 K chip but it would have been detected in the LUMA assay. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Several case-control studies (Grattarola et al, 1974; McFadyen et al, 1976; Adami et al, 1979; Secreto et al, 1983; Hill et al, 1985; Secreto et al, 1991) have reported that a significantly increased risk of breast cancer in post-menopausal women is associated with high levels of testosterone in serum and urine. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | As obese people try to reduce caloric intake—oftentimes through increasing f/v consumption and PA—their hormonal pathways change, causing them to face increased appetite and desire to eat [18]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In fact, elevated local TNF expression was shown to reflect disease severity better than systemic TNF levels in several inflammatory diseases (39, 40), and reduced renal TNF expression was shown to correlate with reduced albuminuria independently of serum TNF levels in mice (41). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The exact incidence of bone metastases is still unknown, although the skeleton is one of the favourite sites for the metastasis of many malignant neoplasms [3]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In all, three patients in group 1 and one patient in group 2 died in the first and fourth year after the operation. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Treatment of granulomatous lesions, in addition to the vasculitic component of GPA, is critical to inducing disease remission and minimizing patient morbidity, but is often harder to achieve and frequently entails the use of cyclophosphamide. |