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This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Pure retrieval anomias accounted for 25% or more of all naming failures in six of the nine patients for whom all relevant data were available. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | While both SLC4A1 and GYPC play an important role in red blood cell morphology and function, the genes that encode these proteins are located on different chromosomes [7,19,20]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | What is important is that in 45.8% our patients iv fluids were stopped within 24 h postoperatively and were replaced with oral intake. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Assessment scales specific for NP have been described (Bennett, 2001; Galer & Jensen, 1997), but the traditional Faces Pain Scale (FPS) and Numerical Rating Scale (NRS) meet the requirements of validity and reliability and are extensively used in pediatric pain management. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Thus, the relative error of the CDI estimated pH could be even more pronounced than the 9 ± 2.6% obtained with the values from the display of the CDI. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In addition, serum creatinine shows a paradoxical inverse relationship with disease relapse; higher serum creatinine levels are associated with lower risk of relapse.4 Therefore, although localized and early systemic GPA lack organ or life-threatening manifestations, persistent granulomatous inflammation is difficult to treat and exposes patients to significant risks associated with long-term immunosuppression.23 The use of methotrexate, in combination with glucocorticoids, has been advocated following a randomized controlled trial, which demonstrated its equivalence at inducing remission in early systemic disease compared to oral cyclophosphamide. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Pacemakers now in the design stage will be potentially more explosive and also more difficult to detect post mortem: both manufacturers and patients favour smaller pacemakers that have greater energy. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We could not locate a prospective study of the incidence of long-term abstinence among cannabis users who try to stop on their own; however, the 8% success rate in this study is almost identical to that for tobacco self-quitters (Hughes et al, 2004). |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Public health policies designed to improve the healthiness of neighborhood food environments by increasing the availability of fruit and vegetable vendors and restricting highly processed and take-away food vendors should be encouraged in south India and other rural communities in South Asia. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Moreover, the data on the functional significance of MCP-1 −2518 A/G SNP are not consistent [13, 16], and the investigated SNP is not the only factor involved in regulation of MCP-1 gene transcriptional activity [12]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We detected both elevated and depressed ABI in HGPS, which likely reflects a composite picture of peripheral vascular stiffening and occlusive disease that could actually yield misleading normal ABI values in this mixed disease setting. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Intriguingly, the second nominally-significant association was between deletions within the FOXP2 gene and decreased BMI, an effect in the opposite direction to that previously reported for the locus. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Depolarization induces outward movement of all four S4 voltage sensors, but fast inactivation is only linked to S4 movements of domains III and IV (30). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | An optimal community service would prevent a majority of hospital admissions by providing diagnosis and treatment early, while fast-tracking those cases that require urgent escalation. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Another strength of the study is that the data about socio-demographic and disease-related factors were obtained from medical records, decreasing the possibility of information bias. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The analytic approach was reasonable for assessing patient characteristic subgroup in which the treatment effect was larger or smaller than in other subgroups (“differential effectiveness”). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | As outlined above, multiple studies have implicated CLU in analyses of cognitive function providing increased plausibility for the findings reported here. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | No differences in the risk of other prediabetic states, such as IFG, were observed between the eating competence groups. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Four of the 50 mitotic entry genes (8.0%) and 8 of the 64 mitotic checkpoint genes (8.1%) tested in this study were associated with either overall or high grade breast cancer risk at the gene-level. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In addition, trabectedin dose reductions became mandatory in case of liver toxicity [increase in bilirubin >ULN; and/or alkaline phosphatase (AP) >2.5 × ULN; and/or aminotransferases >2.5 × ULN] between cycles that has not recovered by day 21 of the cycle4,16. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | These findings should always be interpreted with caution because sexual orientation consists of various components and can change during a person’s lifetime42. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Angiogenin protein became detectable in cell culture media only after at least 48 h of culturing. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Nonetheless, the degrees to which experimental cortisol feedback-associated sex differences in unstressed humans apply to pathophysiological states (26) and/or to classical stress responses, cardiovascular diseases, diabetes, and hypertension (33) remain to be clarified. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In addition, HCV increases the risk for HCC by inducing fibrosis and, eventually, cirrhosis; while HBV can cause HCC in the absence of cirrhosis. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The consequences of neuronal loss in this area include severe anomia, semantic paraphasias and word comprehension impairments in the absence of equivalent perturbations in the non-verbal components of object concepts. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In conclusion, intraoperative remifentanil infusion during anesthesia can cause higher intensity of pain during the immediate postoperative period following thyroidectomy. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Finally, the performance of the model may be overly optimistic due to variable selection bias (a large number of candidate cytokines compared to the number of samples). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Importantly these relationships between objective and subjective balance problems were significantly influenced by the number of brain injuries, use of psychotropic medication, time since injury, and depression severity among participants. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Further studies will be required to define the best methodology to depict the cardiac venous anatomy by CMRA. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The defect is compounded by enhanced cumulative use-dependent inactivation (Fig. 7), which further reduces V1442E channel availability and may explain the abnormal CMAP decrement observed at high-frequency stimulation (Fig. 1). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The opioid requirements were similar to our results, except that the opioid requirement at POD 0 was not significantly different between the 2 groups[citation]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Multiple studies found a relationship between vision problems and lower academic performance suggesting that detection of visual difficulties during childhood is of critical importance in maximizing each child's educational potential 20–23. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Future researches including longitudinal studies should use a larger and diverse study participants utilizing a lab-based methods and using measures of emotion dysregulation and mindfulness specific for adolescents. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, there is no evidence for this viewpoint. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | They noticed reduced LOS in all studies. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In a study from the USA, fast food restaurant density was not associated to blood pressure among low-income housing residents in New York City; however, the study may have lacked statistical power due to its small size (N = 102) (Tamura et al, 2018). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Breakdown into possible outbreaks (≤10 SNPs) revealed five possible ST410 outbreaks (PO10s) in Denmark during 2015 to mid-2017. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Additionally, it is worth mentioning that we analyzed only short-term outcomes: within 30 days after surgery. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Such an improvement has never been described around the more commonly used cemented polyethylene cups [15], metal backed cemented cups [23, 24], or cementless cups [22, 26]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In conclusion, patients who underwent an RAPN had similar postoperative pain intensity to those who underwent an LPN. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Over the preceding decade, randomized controlled trials have standardized approaches to induction of remission and maintenance therapy.6 However, despite continuing improvement in patient outcomes with generalized disease, treatment of early systemic disease, and particularly granulomatous inflammation, confined to the respiratory and ENT tracts is not supported by the same evidence base to guide clinical practice.22 Disease relapse also remains common and PR3-ANCA antibody positivity, most often associated with GPA, and cardiac involvement are recognized as independent risk factors for relapse. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In hospitalized COVID-19 patients who develop VTE, especially in those requiring ICU admission, LMWH at therapeutic dosages may be considered the standard of care. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We validated their usefulness by using three independent datasets. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In the current study, activities during a quit influenced abstinence. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This methodology has been used by some investigators in other fields,19,20 but most prior HIV-1 studies have used calculated concentrations. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This contrasts with a trial evaluating the effect of walnut consumption on colon carcinogenesis in mouse models which observed an increased abundance of Lachnospiraceae spp. during the walnut diet [35]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Who will benefit from prolonged pharmacological VTE prophylaxis following hospital discharge? |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This finding could have occurred for a number of potential reasons. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | CPE is a worrisome risk in public health due to the multidrug resistance and the potential for dissemination to multiple sources, including transmission from patient to patient. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This would suggest that the SLC4A1Δ27 and GYPCΔex3 alleles should assort independently, if the apparent genetic load represented by SLC4A1Δ27 is not increased past a viable threshold by the addition of another significant erythrocyte membrane protein polymorphism. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In this study, we applied a bioinformatics platform, FUMA, to perform functional annotation of GWAS summary statistics reported in the largest international meta-analysis of melanoma susceptibility. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This fraction increased after adjusting for height-age, as the HGPS cohort is extremely small for age, and somatic size as well as chronologic age contribute to BP.24 These elevated BP trends would be expected in the setting of significant vascular stiffness, as prehypertensive adults display both impaired arterial functions and elevated PWV.25 The observed elevation in PWVcf without elevation of pulse pressure in this cohort may be related to overestimation of diastolic pressure by the automated cuff, altered volume status and heart rate in fasting patients, or indicate disproportionate changes in the aorta compared to the peripheral arteries. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Thus, we used the GSE6911 dataset and separately annotated four groups, as described in Results. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Dietary lutein/zeaxanthin intake and the DICER1 rs3742330 genotype were inversely associated in CRC, providing new insight into a protective effect of lutein/zeaxanthin against CRC risk in patients carrying the G allele. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The existence of such a contradiction should motivate health care professionals to inform their patients, especially women from low socioeconomic levels, about the importance of BSE. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This pharmacomorphomic approach may aid in the pharmacokinetic modeling of antimicrobials that require renal dose adjustments, and this covariate for dosing in underweight and obese patients may be superior to traditional body weight-based paradigms. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Finally, generalization of our observed single-site results to other care settings and patient populations should be done with caution. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | With the increasing availability of EIT to our surgical patients and its potential to improve outcomes (possibly in conjunction with intraoperative lung-protective ventilation strategies), large-sample, high-quality research is needed to evaluate the utility of real-time EIT in guiding PEEP titration after major laparoscopic abdominal surgery. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Indeed, many crematoria staff discuss the issue of pacemakers with funeral directors, who are able to inspect the body in an attempt to prevent the cremation of pacemakers. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This value is sufficiently high in order to detect the genetic association described in original study, because it exceeds 80% threshold [17]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our study revealed associations (correlation coefficients ranging from 0.35 to 0.48; P ≤ .05) between diffusion tensor MRI–measured fractional anisotropy (FA) values at 2 weeks of age and Bayley Scales of Infant Development (BSID) scores measured at 2 years of age in healthy infants. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Alternatively, elevated ICA flow velocity may be due to increased flow within the brain due to collateral formation around occlusive disease. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | With femoral plug occlusion, the use of a cement gun and stems of improved design, Harris and McGann found radiographic signs of definite femoral loosening at 6 years in 1.7% of hips [13]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The noise of an explosion may cause distress. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This result is similar to all participants. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This is especially true given the high seroprevalence of C. pneumoniae infection which was corroborated in this study. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This study provides evidence for considerable tradeoffs between immune function and growth among humans. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Specifically, this study shows that epigenetic drugs significantly upregulate BIM expression and induce cell death in ALCL cell lines and suggests that the use of epigenetic modulators may play an important role in the treatment of ALCL. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Besides, complications were not reported as carefully as they are now (no prospective database, no classification). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Significant associations between variants in or near three different genes identified in GWAS of late-onset AD and mean change in scores on tests of cognitive function over a six-year period were found for white middle-aged participants in the ARIC study (MS4A4E, CLU, and NME8), and two variants were identified in African-Americans (ZCWPW1 and CD33) in the primary analysis after adjustment for age, gender, and education. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In ST410, the introduction of blaOXA-181 on an IncX3 plasmid was predicted to have occurred around 2003 (Fig. 3). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Also, the follow up time for BMD change in the SOF cohort was only 3.9 years on average, which might have reduced the chance to identify a significant association between BMD change and the GRS63 in this cohort. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The analysis of rare GSVs for association with complex traits represents a complementary approach to SNP- or sequence-based methods for identifying novel loci that can account for the ‘missing heritability’ of multiple complex traits [citation]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | A questionnaire study on the awareness of early breast cancer diagnosis conducted in the Turkish city of Bursa revealed that more than half of the participants had never undergone mammography or ultrasonography examinations (Yılmaz et al, 2012). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In conclusion, as this study showed, and with the exclusion of patients with prostate cancer, 1.3% of other cancer patients with known primary tumours will present with bone metastases as the first sign of metastatic disease. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The combination of an ARR cutoff value with a plasma aldosterone threshold (> 416 pmol/l or > 15 ng/dl ) has been recommended by some investigations [35,36]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Several GWASs have shown that some genuine susceptibility loci may not reach genome-wide significance but still demonstrate significance after results are integrated through metaanalysis from different populations with bigger sample sizes (57,58). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, many of the covariates assessed are fixed (education, gender, etc.) and therefore could not have been affected by QoL. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our multivariable logistic regression analysis showed that the NLR may independently predict PIR, without being affected by other factors, providing evidence that it is a very useful test in predicting the prognosis of pregnancy. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In previous studies, ACE gene was found associated with rheumatic and autoimmune diseases, so that we aimed to investigate the association between ACE gene I/D polymophism and also MTHFR gene C677T mutation. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The highest relative risks are in the center of the factory close to the balcony, while the lowest risks are in the areas at the sides and far end of the factory floor. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Treatment with a gluten-free diet can dramatically improve bone density, especially where there is osteomalacia, but it can also lead to improvement when osteoporosis is the underlying lesion22. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Retrieval studies by Lintner et al. [20] have shown excellent biological fixation of pressfit grit-blasted titanium endoprostheses and this has been confirmed experimentally by Feighan et al. [10]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Furthermore, further evaluation regarding whether these observed changes are preserved during longer walnut consumption is required. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Three years after dorsal instrumentation, on the other hand, two patients suffered superficial infection in the region of the scar, probably because of internal mechanical irritation of the implant. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | To our knowledge, most studies examining pharyngeal transit in aged humans used discrete, rather than self-selected, bolus sizes [9, 44]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The reason for the absence of significant difference might be that the patients were generally discharged between POD 5 and POD 7 if there were no significant postoperative complications, such as postoperative bleeding[citation]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The negative association between LUMA methylation and later age at menarche is counter-intuitive because (a) a later age at menarche is known to protect from breast cancer, and (b) lower global methylation is expected to increase genome instability and thus increase cancer risk [8], [26]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | As suggested by Duckett (1992), methods of increasing tolerance should be examined systemically, on multiple levels, to more fully understand the moderators and mediators that lead to more widespread and sustainable outcomes. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Finally, the diagnosis of type 2 diabetes was assessed based on the results of one OGTT. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Compared with the severity of the initial clinical findings, the intraoperative and postoperative complications in our patients were minor and not solely connected with the operation. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In contrast with findings from high-income countries, improved safety from crime and aesthetics reduced the odds of active commuting. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We found that for adults from multidimensionally poor households, median time to arrival at the referral hospital was approximately one day longer than for those from non-poor households. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The US Preventive Services Task Force (USPSTF) in 2011, while agreeing with the importance of vision screening in children ages 3 to 5 years of age, concluded that the current evidence was insufficient to assess the benefits and harms of vision screening in children < 3 years of age, citing costs of false-positive rates, and concluded that screening and treatment of amblyopia later in the preschool years may be as effective as screening and treatment done earlier in life 2. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Recent studies indicate that E. coli ST410 is another successful pandemic extraintestinal pathogenic E. coli (ExPEC) lineage similar to ST131 (5, 16). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In an in vivo study, inactivating Dicer1 in a mouse model showed that it functioned as a haploinsufficient tumor suppressor in retinoblastoma and promoted hepatocarcinogenesis53,54. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Identifying the regulatory pathways through which body fat exerts a buffering effect on inflammation-related tradeoffs is an important area of future investigation. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Another possibility is that since the cognitive tests were administered to middle-aged adults whereas only 4% of those with AD are estimated to be younger than 65 years of age [Hebert et al 2003], the relationship between rs670139 and cognitive function in particular may change over the life course so that MS4A4E is beneficial in early life and has different effects at older ages. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | If the CDI has not been gas calibrated, its values are inaccurate and imprecise for pH and pCO2, and thus unreliable in this situation, and the result may very well be a less than optimal blood gas management of this critical period of CPB. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | First, they provide evidence that individualized reading instruction is more effective in improving students’ reading skills than instruction of similar quality that is not individualized; this was true at a single grade, and the findings were more consistent for first and second grade. |