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This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Improvement of oxygen supply is one of the key concepts in reducing mortality and the rate of complications in septic patients24. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The high level of sensitivity, confidence and self-efficacy and health motivation, and low level of obstacle perception of the participants who had breast cancer in their families indicates that these women are more aware of breast cancer risks. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The analysis of metabolic fingerprints might be useful to understand how microbial structures are influenced by regular walnut consumption. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | First, identification of developmental BMIz trajectories in the first 2 years may be helpful in identifying high-risk groups. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Half of the women approached were not eligible for inclusion in the cohort, and we had no wish to generalize our findings to ineligible women and children. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Cross-sectional analysis of 401,917 UK Biobank participants revealed a weak inverse association between distance from a fast-food outlet and waist circumference and BMI (AlHasan and Eberth, 2016). |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Adequate treatment of recurrent depression should provide symptom relief for the current episode, protect against relapse and prevent recurrence (for example, Montgomery, 1994; Kasper et al, 1997; Keller, 1999; Keller and Boland, 1998). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We addressed the cellular origin of angiogenin in SF. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Although the authors noted that these harmful effects depended on the degree of hyperoxia and were more prominent in certain subgroups, a high intraoperative FiO2 might be considered unnecessary and even disadvantageous. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This position is seemingly more comfortable than the prone position, with the patient’s shoulders being less stretched back and breathing less affected by lung compression due to thoracic weight. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Furthermore, for our experiments, we used human renal tubular cell line immortalized by Adeno5/SV40 virus. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Recently Linde and Mulrow (2000) have suggested to compare the antidepressant efficacy of Hypericum extract with standard antidepressants in well defined groups of patients over longer periods of observation as well as to study different extracts and doses (for a discussion of therapeutic alternatives to Hypericum extract in long-term prophylaxis of depression, see Winkler et al, 2002). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Based on this result, we might hypothesize that apoptosis and organ damage were induced by these inflammatory mediators. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In one of our patients, the distal screw was observed to have broken away from an osteoporotic thoracic vertebral body 3 months after the operation. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | It would be interesting to determine whether TNF-induced podocyte injury is linked to the formation of cholesterol crystals, a phenomenon that was recently shown to be prevented by HPBCD in macrophages in the setting of atherosclerosis (57). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In a setting where hospital admissions pose considerable financial strain, and where in-patient demand exceeds provision, recommendations that leads to too many hospital admissions could be as dangerous as those that lead to too few [32]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | One of the principal risk factors for fracture at any given skeletal site is the bone mineral density at that site,13 and it is the occurrence of potentially debilitating fractures resulting from minor injury in patients with coeliac disease that has led to concern over the eVect of coeliac disease on bone density at sites of fracture risk. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Further, CEACAM1 plays an important role in the change from endothelial cells to an angiogenic phenotype during prostate cancer development,24 and BRCA1 is regulated by the androgen receptor and often mutates in prostate tumors 25. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We liimited homiiologous blood transfuisions to patients with evidence of hypovolemia in the intensive care unit ancd wvith hemoglobin values less than 8.5 g/dL, to patients with asthenia and tachycardia after mobilization in the ward, or to patients with severe anemia (hemoglobin <7 g/dL). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Future research could examine the effects of antiparkinsonian medications using this model, or the effect of aging combined with parkinsonian models. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Gaining a clear mechanistic understanding on how dysfunction of heart can lead to kidney organ failure is critical to identify potential treatment targets and disease management strategies. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Therefore, the patients whose disease was mainly localized to one lung and who could tolerate pulmonary resection were considered for surgery. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | And “In this house we don’t see each other as different colors, we are a family” Theories of psychological change may be useful to understand the ways in which the Oxford House self-help process may facilitate increases in diversity. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Conversely, high SF angiogenin levels were found in patients with acute crystal-induced inflammation, namely, gout attacks. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Furthermore, although subjects carrying a highly-penetrant causative variant might naïvely be expected to display the phenotype regardless of ethnicity, geographical origin or environmental exposure, we have very little information on the potential for cohort-specific modifiers that can confound that expectation, or on differences in the frequencies or characteristics of rare variants between different populations. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | PWV is inversely related to arterial wall distensibility, and serves as the gold standard for measures of arterial stiffness 22. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Second, we discovered abnormally echodense vascular walls in the HGPS cohort. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Further investigation into the role of oestrogen on repetitive element methylation is, therefore, warranted. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Third, even evidence-based and culturally adapted complex interventions may be insufficient for populations bearing a heavy burden of health disadvantage. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | A conspicuous feature, however, was superficial wound infection, caused by internal mechanical irritation of the dorsal instruments. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Due to the fact that this approach to gastric cancer patients is rather new, more studies are required to further increase the validity of this concept. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | It has been reported that blocking antibodies have a protective activity by inhibiting immediate as well as late inflammatory responses and long-term ameliorating activity on the allergic immune response by antagonizing the underlying IgE production [29]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In conclusion, environmental factors can affect the onset of CHD and AKT1 rs1130214, rs3803300 polymorphisms involve in the generation and development of CHD. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The study of Dahlui et al, (2011) revealed that university students gathered most of their information from family and friends, and the internet was the second tool they used for acquiring information. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Lack of prior HCV diagnostic information could lead to an underestimation of HCV screening rates. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Some recent studies performed in this occupational setting in our country, among both HCWs and HCSs trained at teaching hospitals, reported similar encouraging evidences 10,20. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | On the Hang et al.’s data, they suggested that ACE I/D gene polymorphism I allele is a risk factor for early onset, severe form of primary knee osteoarthritis [8]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Many studies of cannabis abstinence or reduction focus on a single attempt to stop or reduce cannabis use, and many do not follow participants after they relapse. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | All of the DSM 5 cannabis withdrawal symptoms we tested changed as expected on abstinence days even though many attempts were short-lived. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, the patients’ perception—and hence response to the question—of limping may not match an objective measurement of limping. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | As a consequence, the presented effect sizes for MrOS Sweden might be slightly overestimated. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This is the first published report of the frequency and consequences of pacemaker explosions in crematoria. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In most studies, N-acetylcysteine was administered orally at least 24 h before CM. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In addition, adjuvant IFN-alpha for the treatment of high-risk melanoma significantly reduces the risk of relapse and has been shown to improve melanoma patient survival (45,46). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | A prospective randomized study is needed to clarify this point. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Taken together, our results suggest that ANP-mediated inhibition of metastasis occurs through inhibition of the inflammatory response. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In contrast, ANP is an endogenous and physiological peptide and has been proved not to cause severe adverse effects when used in patients with heart failure (35). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In conclusion, this study adds to the growing knowledge about seminal plasma cytokines and HIV-1 RNA levels in untreated men with chronic infection. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | There was only one child at risk for strabismic amblyopia with an abnormal reading for gaze asymmetry. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Terry et al. [18] found that a later age at menarche was associated with higher genomic global methylation later on in adulthood, but DNA methylation was only assessed in 92 individuals and the authors used a different technique for measuring global methylation ([3H]-methyl acceptance assay). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | For example, during a complex tongue protrusion test, average, but not maximal force generation was affected by 6-OHDA lesions [69]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Maintenance of a stable high BMIz trajectory or accelerated BMIz gain was strongly associated with higher adiposity and increased obesity risk, while maintenance of a stable low BMIz trajectory protected against increased adiposity and obesity risk at 5 years, in line with earlier findings17, 18. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Loss of fornix white matter has shown to be a strong predictor of cognitive impairment in the elderly (26). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The data here are likely to under-represent the true circulation of EV-D68 and other enteroviruses in Wales, as most patients with acute respiratory symptoms, will not undergo testing. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, as antibody levels of the latter two were still detectable, it is advisable for clinical laboratories to perform chlamydial antibodies by MIF as a panel, rather than offer them separately. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Elamaran [23] used a quantitative RT-PCR assay to analyze the effects of O2 concentration (5% vs. 20%) on the relative abundance of gene transcripts in buffalo embryos produced in vitro and noted an increased expression of anti-apoptotic genes BCL-2 and MCL-1 and a decrease in the expression of pro-apoptotic genes BAX and BID in pre-implantation stage if culturing under 5% oxygen concentration. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Furthermore, the strong biological rationale used to select these genes suggests that the observed associations, while not statistically significant, may be genuine. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | It seems that higher education provides more opportunities to get a better job and monetary benefit compare to lower education in Korea. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Consequently, contaminated dust may have been dispersed or cleaned up in the interim. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, our study suggests that self-efficacy and physiological challenges may limit the effectiveness of these strategies. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Because most of these discordant cases had serology and direct detection testing drawn at or around the same time point (Table (Table2),2), this scenario is not unlikely. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Poloma and Pendleton (1991), for example, pointed to the different types of prayer and state that these differences determine the experiential consequences of prayer such as general well-being. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The overhanging balcony may have sheltered employees at some of the machines from any contaminated dust falling from above. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Similarly, as participants beliefs in viewing medicines in general as harmful and being overused become stronger, they take a lower total weekly dose of analgesic. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Other studies have suggested that lutein/zeaxanthin bioavailability affects carcinogenesis via its antioxidant properties by inducing apoptosis and proliferation, preventing oxygen radicals, regulating gene expression, and activating the immune response6,12,21,40. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Opioid tolerance is a progressive decline in response to opioids, which increases demand. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Utilization of intravascular contrast agent may allow for a longer time window for contrast-enhanced imaging, as well as repeat of measurement if necessary. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | It may also be that younger patients need further persuasion by multiple home BP measurements to be willing to accept the diagnosis of hypertension and need for treatment. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Trends in the past decades show a rapid shift towards an earlier age at menarche and this is more pronounced in developed countries [33]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Pattern may also be important since no clinical investigations of negative feedback have yet attempted to emulate a physiological train of cortisol pulses (citation). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Also, a randomized study with 3-month follow-up showed this tendency in both surgeon-reported and patient-reported outcomes (Witzleb et al 2009), although the differences were not statistically signifi cant. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | de los Santos et al. [18] in an ovum donation cycles found that reduced oxygen tension improved embryo quality but not clinical pregnancy rates in a cleavage-transfer program. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This suggests that circulating TNF in DKD but not in FSGS may at least in part contribute to increased glomerular TNF expression. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The experimental model used here does not discriminate between these two principal possibilities. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | While SOAT1 activity is likely to be tightly regulated to maintain cholesterol homeostasis in normal podocytes, the possibility that altered SOAT1 activity contributes to podocyte injury in disease conditions warrants further investigation. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Unfortunately, the CKD patients were recommended the use of aldosterone antagonists [32]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The St Jude Pharmacological Guidelines for Pain Management indicate a starting dose of 0.1 mg/kg orally at bedtime, with the option of doubling the dose every 3 to 5 days up to a maximum dose of 1 mg/kg. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Indeed, we will follow the current population of this study for several years. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In recognition of a body fat-dependent relationship with growth, we follow others (50) in proposing that recurrent inflammation during childhood may have lifetime developmental effects on metabolism, energy use, and health. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | These issues should be addressed before making any fi rm conclusion about the superiority of one approach over the other. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | More research is needed to understand and assess additional factors (e.g., socio-economic status, car ownership, commuting patterns, and travel distances) and their relationship with active commuting across larger geographical areas and over extended periods of time in LMIC contexts. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | As new analgesic strategies were incorporated, stages in the evolution of pain management during the 26-year study period were defined, as indicated by the timeline represented in Figure 1. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | On the other hand, a high-fat Western-type diet in mice resulted in an increased abundance of Firmicutes and a decrease in Bacteroidetes [19,24,25]. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | These findings highlight the importance of educational interventions as well as the importance of adherence to ARV treatment in HIV patients to improve their general QoL. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Despite our efforts to address community health priorities, deploy evidence-based interventions grounded in behavioral theory and research gold standards, we observed few statistically significant changes in increasing PA or f/v intake. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Some explanations of this discrepancy in NGAL role in different studies may lie in the utilization of different sample types for NGAL measurements (urine and plasma) with probably different pathophysiological mechanisms and different methods for NGAL detection with different sensibility and specificity. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | A 17-item HAMD total score of 16, one of our relapse/recurrence criteria, indicates mild depression requiring treatment and has thus been used as an entry criterion in many clinical trials (for example Reimherr et al, 1998; Kalb et al, 2001). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | On the other hand, the diarrhea in IBS-D patients may be the result of other factors, such as alterations in gut permeability, inflammation, or microbial flora. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | It has been pointed out that reducing DUP through early detection may be possible from a service systems perspective (citation, 1999), and our data support this notion. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Unfortunately, we observed no significant evidence of association between SNPs identified by HCV-related HCC GWAS and the risk of HBV-related LC, which also failed to be replicated in our own HBV-related HCC GWAS population. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, in other studies, childbearing history and even mother's pregnant age also participate in CHD occurrence[citation]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The placentas of common rodents can also contain large numbers of C. burnetii sporelike forms (21) and could contaminate straw. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Indeed, parents who are highly educated are more likely to recognize the symptoms of atopic dermatitis and to see doctors than are parents with less education [38]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | It is noteworthy, that females are also less affected behaviorally in our stress model (see: Supplemental Fig. 1 and Hohmann et al 2012a). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We integrated SNPs at the level of whole genes and performed a gene-based analysis with FUMA. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In our study, with the exception of only one individual, falls were not reported as an issue, but our cohort did report difficulty with high level physical daily life activities and frustration related to their balance problems, which may have a negative impact on their quality of life. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Therefore, it could be argued that, after the initial diagnosis and treatment, follow-up screening for all cancer patients without evidence of bone metastases and in the absence of skeletal pain should include a complete clinical and laboratory examination including tumour markers. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Furthermore, the cortical changes, resulting from the stress exposure, are subject to modification by behavioral exposure in young adulthood. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Although three previous studies5,10,25 have examined differences in MMPI-2 scores according to gender, age, and sexual orientation, to our knowledge, the present study was the first to report MMPI-2 scores for a large sample of French transsexuals according to their biological sex, age, hormonal therapy status, onset age, and sexual orientation. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, because our analysis was based on a relatively small number of genes, a larger study will be needed to identify the best predictors of disease outcome overall. |