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This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | A recent report suggested that stance time variability in a similar cohort of 379 elderly subjects was a significant predictor of mobility disability [17]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In our study, there was no significant differences between the means of male and female groups for the overall and anterior Bolton’s ratios. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We, herein, demonstrate that the GRS63 is associated with BMD, but not BMD change. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | With 14 subgroup interaction tests, some of our findings may represent chance findings, so our results should be interpreted cautiously and considered hypothesis-generating. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Diet assessment of each participant confirmed that all the patients were ingesting gluten in the weeks prior to entry to the study. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This suggests that the associations of eating competence with metabolic risk factors of type 2 diabetes are not fully explained by the difference in BMI between ECPs and NECPs. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The coalescence analysis (Fig. 2 and and3)3) on the global collection of 127 ST410 isolates indicated a most recent common ancestor approximately 214 years ago (the early 1800s), with confidence intervals stretching 30 years backward and forward. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | C. burnetii sporelike forms are resilient. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Based on these preliminary results, we may speculate that CRS Type 5 could result from an uncontrolled and deregulated inflammatory response. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The temporal distribution of EV-D68 activity in Wales is broadly similar to reports from outbreaks previously described elsewhere, including emerging reports of EV-D68 activity and AFM in 2018 from the US [7,8]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | It would be interesting to follow IPH and IgGSD patients as well as AFM over time (especially young individuals), to see whether their immunophenotype approaches that of patients with CVID. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | It is likely that such under-sampling would be non-differential, affecting poor and non-poor groups equally; this would bias the results toward the null hypothesis, and lead to a more conservative estimate of difference between poor and non-poor populations. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our preliminary analysis of the relationship of both GYPCΔex3 and SLC4A1Δ27 to malaria susceptibility in Liksul revealed no association with the prevalence of P. falciparum or P. vivax prevalence or parasite density. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | According to the authors, these differences cannot be entirely explained by age.18 Our study has several limitations. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In the most rigorous study of non-treatment seekers, alcohol substantially increased (+8 standard drinks/week) as did tobacco use (+2 cigs/day) during abstinence (Allsop et al, 2014). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The range of prevalence of cutaneous lesions observed is comparable to that reported by Cavanagh et al (2002) in the same area, where overall prevalence of external signs was approximately 2%, but reached levels of 8% in April. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Most teachers in this study, when given training and support, were able to provide more effective literacy or mathematics instruction in line with their treatment assignment. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The Graded Object Association Task confirmed the presence of an abnormally intense interference effect in the PPA group and also demonstrated its selectivity for verbal rather than non-verbal associations of objects. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | A longer learning curve and increased operative time are among the main disadvantages of minimally invasive access to gastric cancer surgery. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | By implication, teachers who are generally less effective can learn to improve their classroom practices in ways that improve their students’ test scores. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Accurate gene regulation is a safeguard in heart formation, furthermore, most of CHD patients occur in embryonic period, which may be caused by the structure and function of genes regulating the differentiation and morphogenesis of myocardial cells. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The purpose of this study was to develop assays of deglutition behavior in rats using videofluorography and to determine if signs of dysphagia would be evident by videofluorography in aged and parkinsonian rats. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Investigating the process used to make the straw board indicated that the low pressures and temperatures involved would not kill any fungal spores present in the straw. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | A large majority of the prior evidence on built environment correlates of active commuting was limited to high-income countries, and more recently, some LMICs in South America and Africa [56,57]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The rats were separated from the dam three times daily, for 15 minutes each, between postnatal days (PND) 4 and weaning at PND 21. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Previous epidemiological studies have shown conflicting data regarding the association between lutein/zeaxanthin intake and CRC risk. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our findings strongly support the recommendation by the regulatory health Agencies to screen and booster susceptible individuals belonging to high-risk groups, such as professionals employed in health care services. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Children 5 years or older who are expected to experience moderate to severe pain for at least 24 hours can benefit from PCA analgesia; it can also be safely used for younger children with the assistance of nurses or family members educated on the use of PCA (Anghelescu, Burgoyne, Oakes, & Wallace, 2005; Chiaretti & Langer, 2005; Kost-Byerly, 2002; Wuhrman et al., 2007). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Consistent with previous reports, SLC4A1Δ27 was rare in the Wosera and no SLC4A1Δ27 homozygous individuals were identified in either population [6,20]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | While the magnitude of morphological changes we describe may be unexpectedly large, it is not out of proportion with other studies we have conducted using the same morphometric approach in Balb/CbyJ mice (Hohmann & Berger-Sweeney, 1998; Hohmann et al, 2000; Krasnova et al, 2007). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | A patient navigator-based intervention to promote engagement in smoking cessation treatment was feasible and acceptable to low-income and minority patients in a primary care setting. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, the experience of the surgical team in perioperative care based on ERAS protocol principles is mandatory to provide high compliance with the protocol. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | More convincing data are needed to provide tailored oxygen targets for clinicians. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Future research should focus on more targeted, longitudinal studies, and other methods including case control studies and trials into specific interventions to see if they are useful for increasing emotion dysregulation and dispositional mindfulness in this vulnerable population. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Moreover, when comparing the frequency of the DICER1 rs3742330 allele, carrying a G allele (AG + GG) was significantly associated with a decreased risk of CRC compared with AA homozygous carriers via a dominant model. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Overall, our results suggest that DNA methylation changes, particularly in repetitive elements, may be associated with menarcheal age. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | As with aging, this implies that visible plaque occurs later in disease. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Recent investigations of pulsatile versus continuous glucocorticoid effects upon the expression of central-nervous-system genes (15) provide a possible experimental framework for studying these questions in animal models as well. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Thus the present inferences require confirmation in larger cohorts sampled over 24 h. Additionally, the conclusions of this study apply to healthy older adults and not necessarily to children, adolescents, premenopausal women, chronically stressed individuals, or ill patients. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Caspase-8 is an intracellular cysteine protease which plays a central role in the initiation of apoptotic cascades and caspase-9 is the most upstream member of the apoptotic protease cascade that is triggered by cytochrome c and ATP. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Whereas there were no differences in TJ protein mRNA expression according to HLA type in our current study, ZO-1 protein expression data suggest that HLA type may influence alterations in intestinal permeability to sugars, but larger studies are warranted. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Daily consumption of 43 g walnuts resulted in significant changes in composition and diversity in the gut microbiome by enhancing probiotic- and butyric acid-producing species in healthy individuals. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Suboptimal in vitro culture conditions, specifically exposure to high oxygen concentrations have been associated with increased reactive oxygen species (ROS) generation and compromised developmental ability. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The FtMs, in comparison with the MtFs, seem to pass more easily for the opposite gender25. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | As previously described for endothelial cells [35], angiogenin release by synovial fibroblasts increased with cell density, suggesting that excessive proliferation of synovial cells in inflammatory joint disease may result in accumulation of the angiogenic protein. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This could be expected as most individual SNPs included in the GRS63 were significantly associated with BMD in both sexes (15). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In his preface to the Dictionary, Johnson felt compelled to write, ‘I am not yet so lost in lexicography as to forget that words are the daughters of earth, and that things are the sons of heaven’ (Johnson, 1755). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In smoking population, we gained the similar conclusion. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Overall, the mucosal barrier data are consistent with the hypothesis that gluten sensitivity (without celiac disease) may represent a separate entity in the spectrum of IBS-D patients. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The prospective studies of Berrino et al (1996) (24 cases) and Dorgan et al (1996) (71 cases) both reported a significant association between breast cancer risk and total testosterone concentration, quoting adjusted odds ratios of 7.0 and 6.2, respectively, for the top category of the concentration distribution. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | By contrast, we chose a HAMD total score of 20 for inclusion into acute treatment in order to obtain a patient sample with a higher degree of pathology so that a sufficient number of ‘terminal events’ during the continuation and maintenance phases can be expected. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, pneumoperitoneum had a considerate influence on the change of ventilation distributions, and the 8 or 10-cm H2O PEEP was not sufficient to prevent a secondary ventral shift in all patients. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Further investigation regarding how lutein/zeaxanthin impacts miRNA associated DICER1 expression levels and miRNA processing machinery relative to CRC risk is needed to understand the associated molecular mechanisms. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, this outbreak is the first where straw board was suggested as a possible source of Q fever. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Epidural opioid analgesia targets drug delivery to the site of pain, thus requiring a lower dose of opioid, and exerts a synergistic effect with local anesthetics. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The results suggest that the majority of Georgian HIV-infected patients had poor general QoL. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | For example, performance in at least one test of non-verbal object knowledge exceeded the 90% level of accuracy in 5 of 11 patients. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | 27 To differentiate the changes of hemostatic parameters observed in COVID-19 patients from those observed in patients with DIC and consumptive coagulopathy of other etiologies, the term pulmonary intravascular coagulopathy (PIC) has been introduced. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The high rate of recurrence of these deletions likely contributed to their early discovery and replication using these methods. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We may build appropriate model for assessing the risk of hypertension and for identifying high-risk factors, which could early screen the high-risk groups of hypertension and provide the basis for the developing interventions for hypertension. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | From the global analysis, the close genetic relationship between four ST410 isolates isolated in the United Kingdom and the genomes from Danish ST410 isolates from PO10-3 could indicate a similar introduction to the United Kingdom; however, two of the patients from the United Kingdom reported no travel prior to hospitalization, and for the remaining two, travel information was unavailable. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The image quality of cardiac veins can be improved as a result. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Measuring the NLR in a pregnant woman experiencing preterm labor or pPROM may reduce the frequency of unnecessary amniocentesis to as low a level as possible. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In this study, we found that angiogenin was present at similar concentrations in plasma from both healthy subjects and rheumatic patients in the same range as those previously reported [35,37]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Moreover, children with greater body fat were able to completely avoid the detrimental effects of acute inflammation on 1-wk growth, suggesting that childhood adipose energy reserves play a critical role in buffering immune-related tradeoffs. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Results indicated that for religious affiliated patients high levels of prayer were related with lower levels of pain severity whereas this is not the case for religious non affiliated patients. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The effect of pistachio consumption on gut microbiota composition was again much stronger compared to that of almond consumption. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In all patients with confirmed SARS-CoV-2 infection, the indication for pharmacological VTE prophylaxis with LMWH (or alternatively with fondaparinux) should be evaluated on a regular and permissive basis, regardless of the need for hospitalization. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | For instance, Cushieri et al. noticed a complication rate of 46% [2]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This finding is inconsistent with prior literature that suggests a stronger relationship between body size and volume of distribution, including a study of over 2,000 individuals with diverse body sizes, which found an R2 of 0.2 between volume of distribution and lean body weight (1, 6). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Previous studies using navigator-gated, whole-heart SSFP CMRA demonstrate that MR can visualize the anatomy of the cardiac venous system at 1.5T [6–10]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This result is lower than those obtained in 2 recent Italian studies that showed a proportion of seroprotected subjects vaccinated in infancy and adolescence of nearly 77% and 88% respectively, after similar period since HBV vaccination.10,20 However, previous studies have reported that 40–60% of subjects vaccinated in infancy had a seroprotective ant-HBs level after 15–20 y since vaccination, meanwhile the prevalence rise to 85–90% in those vaccinated in adolescence after 10 y since vaccination.21,22 The immune response in subjects vaccinated during infancy showed a physiological decline in terms of anti-HBsAg antibody concentrations, a well known phenomenon already reported.18 The antibody concentations decline observed in our study didn't impact on the protection of vaccinees against HBV, thanks to the immunological memory acquiered with the infant immunization course. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The effect of these components can only be addressed by a different study design. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This result is similar to that of Australian study where the mean social anxiety score was 2.22 [5]. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Research drawing attention to the socioeconomic factors shaping the biobehavioral processes of energy balance holds further relevance for vulnerable populations—urging attention to the relationships between inequality and physiology. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | STAT4 is a transcription factor belonging to STAT family23, important members of Janus Kinase (JAK)-STAT pathway, that is required for the development of Th1 cells from naïve CD4+ T cells24 and interferon-γ (IFN-γ) production in response to interleukin-12 (IL12)25 and type I interferon (IFN-α or IFN-β)26. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, we consider that the statistically non-signifi cant between-group difference of ~3 HOOS points in all the HOOS subscales included, in favor of PA, was not clinically relevant—based upon current evidence (Frobell et al 2008, Roos 2012, Villadsen et al 2014, Kise et al 2015, Kise et al 2016). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Second, we could not control for the dose of remifentanil. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Although we informed the patients and primary care physicians of the results and assigned patients with CKD to a lower BP goal, there was no system-wide effort targeting BP control in patients with CKD. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Osteomalacia, but without the additional factor of secondary hyperparathyroidism, was also present in cases 2 and 3. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In addition, it is likely that EV-D68 in the community was mostly undetected, due to potential under-ascertainment of mild cases and under-sampling. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Study Limitations The response time from when the blood comes into contact with the CDI sensor and until the results are displayed on the screen is less than 1 minute, and the display of the CDI is updated every 6 seconds. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The remaining eight patients also displayed major word association and comprehension impairments as revealed by the PPVT, a result that agrees with a previous study on a more heterogeneous group of PPA patients with and without anterior temporal atrophy, where PPVT performance was most strongly correlated with atrophy of the left anterior temporal lobe (Rogalski et al, 2011). |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | As demonstrated in this study and described in our previous studies, maternal blood NLR may be considered the most useful, noninvasive prenatal diagnostic method currently known. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, certain types of deglutitive deficits found in the aging and parkinsonian rats may parallel deficits found in the human. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Second, the participants were initially selected based on their increased risk for type 2 diabetes, their average BMI was high, and men were underrepresented, which limits the generalizability of the results to general population. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Nevertheless, screening for this secondary hypertension is widespread. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | First, the doctor signing the form may mistakenly report that there is no pacemaker in the body or the form may be incomplete. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In the study, significant increases in Par j 2-specific IgG and IgG4 and a significant decrease in Par j 2-specific IgE have also been found. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This implies that participants recognized the potential seriousness of AFI and its responsiveness to treatment, but that barriers to care associated with poverty arise from an early stage. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | These recommendations are highly welcome, but several trials, each with a large number of patients, will be needed until definitive conclusions can be drawn. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, the necessity of different measures from those used for human swallowing does not negate the validity of this animal model. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | For intermittent episodic pain, patients use as-needed or around-the-clock doses of oral immediate-release opioids or intravenous (IV) opioids, whereas for continuous pain, continuous IV infusions, PCA, or oral long-acting opioids, plus additional breakthrough doses, are recommended (citation, 2003). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Olson et al, in fact, proposed that the Oxford House model provides an excellent field-based setting for exploring transtheoretical processes for men and women in addiction recovery. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The long-standing discussion regarding the oncological safety of minimally invasive access was addressed in recent meta-analyses that clearly showed that it is non-inferior to open gastrectomy. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Further, multi-component interventions have shown the most promise in reducing health disparities, (Chin, Walters, Cook, & Huang, 2007) suggesting that combining interventions may be one approach to promote smoking cessation among low-income and minority smokers. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Other Latino individuals stated that “There’s really no prejudice there (Oxford House). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Previous reports in AAV have similarly employed 4 RTX doses at 4 weekly intervals administered at 375 mg/m2 10–12. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Differently, both of rs1130214, rs3803300 polymorphisms were independent association with CHD susceptibility. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In particular, compared to CVID and IgGSD patients, a higher proportion of IPH patients had unusual infections (i.e. warts, fungal infections), although the difference was not statistically significant. |