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This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | To our knowledge, this is the first report to examine the miRNA associated DICER1 gene and dietary interaction as part of CRC etiology. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Sensitivity overall for detection of visual abnormalities associated with risk factors for amblyopia ranged from 72% (iScreen) to 84% (Plusoptix), and specificity ranged from 68% (SPOT) to 94% (Plusoptix) 17. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | It is interesting to note that similar findings with regard to SLC4A1Δ27 and α-globin deletions (located on chromosome 16 and associated with α-thalassemia) have been reported in earlier studies in Madang [24]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The most striking finding from this study is the sharp gradient of risk of breast cancer with serum oestradiol concentrations in postmenopausal women, with the upper third of the distribution approximately five times more likely (95% confidence interval approximately 2-12 times more likely) to develop breast cancer than those with oestradiol concentrations in the lowest third. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, the computational complexity of this process grows exponentially with the depth of search for optimal plans, which makes it infeasible to implement in all but the smallest environments. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Regarding limitations, the study was designed as a superiority trial We cannot therefore conclude that LA is not inferior to PA. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Donor Registries and Transplant Centers must both commit to more intensive efforts to incorporate new factors into the search process for any meaningful advances in donor selection. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Only CR1 rs6656401 was associated with a global measure of cognitive decline while genetic variants in CLU (rs11136000) and PICALM (rs7110631) were not found to predict cognitive change in these cohorts [Chibnik et al 2011]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Additionally, we observed altered seminal plasma-to-blood plasma ratios of IL-1α and IL-10 in subjects with detectable HIV-1 RNA levels in seminal plasma. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | A number of gene polymorphisms involved in development of knee osteoarthritis have been identified, such as those localized in or adjacent to the encoding sequences for the vitamin D receptor [14,15], estrogen receptor alpha [19], calcitonin [20], interleukin-6 [21], SMAD3 [7], and matrix metalloproteinase-1 [22]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Meintjes et al. [19] also observed that human embryos cultured in 5% oxygen consistently yield better clinical results in a fresh blastocyst-transfer (BT) program. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In order to manage liver AEs, after the first clinical experience with trabectedin, dexamethasone administration was routinely implemented to improve tolerance. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We investigated the associations of eating competence with reported dietary intake and physical activity, and with metabolic risk factors for type 2 diabetes, in a large group of Finnish adults screened for type 2 diabetes risk. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The variant allele of DICER1 rs3742330 is associated with CRC despite inconsistent patterns in recent literature. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Despite the favorable treatment outcomes, postoperative complications were relatively high (35%) with NTM lung disease in our study. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The beneficial effect of co-trimoxazole, alone or in combination with glucocorticoids, at achieving remission in localized GPA has been reported in single centre cohort studies25–27. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, when a new piece of information on a leaf at depth d is achieved, its policy-improvement impact on the root-level actions is measured at the root of the tree, thus discounted by a factor γd. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | When social support from close friends, relatives, and teachers were higher, adolescents reported lower symptoms. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | From the original study of Bolton,27 2 standard deviations from the Bolton’s ratio were considered a tooth size discrepancy. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Beneficial effects of ARV treatment on QoL might be explained by decreasing intensity of clinical symptoms of the disease. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our model is exploratory, and did not control for multiple testing. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In addition, intermittent streptomycin for the first 2 to 3 months of therapy was recommended for extensive disease. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In general, we found that supportive environments were associated with more active commuting and public transit use. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | If straw board becomes wet, these fungal spores often sprout and damage the board. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | These findings challenge the translatability of systemic TNFR1 and TNFR2 from their strong role as biomarkers to a potential role as therapeutic targets. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This pattern of feeding and swallowing behaviors is distinct from human swallowing in traditional videofluorographic studies, where the bolus is presented for a single swallow and oral residue is considered abnormal, with the exception of continuous eating. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, we found that the postoperative pain was not significantly different between patients who underwent LPN and those who underwent RAPN. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The unimodal approach to nociceptive pain (1981) Opioids remain the most important class of medications for relief of moderate to severe postoperative pain (citation 2007). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Category specificity of lexicosemantic deficits for natural kinds versus artefacts, frequently reported in patients with semantic dementia (Warrington and Shallice, 1984; Humphreys and Forde, 2001; Zannino et al, 2006), was not detected in the present study. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | It has been described in patients with dysfunction in Brodmann area 37, inferotemporal cortex and several other regions of the left hemisphere (Benson, 1985; Grossman et al, 2004; DeLeon et al, 2007; Antonucci et al, 2008; Rohrer et al, 2008). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Therefore, other experiments and a higher sample size are necessary to better understand inflammatory aspects of CRS Type 5, CRRT, and the humoral signalling. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Similarly, rate of relapse remained high and additional immunosuppression was required in the majority of patients28,29. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Future investigations of tubular damage markers and inflammatory cytokine levels in patients plasma are required to determine cellular and humoral factor expression that engenders immune-mediated imbalances. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | It might have been possible to prevent the ventral implants from breaking away by involving a further, stable vertebral body in the ventral spondylodesis, or through additional dorsal instrumentation. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Therefore, we hypothesize a dual apoptotic signal activation: intrinsic and extrinsic pathway may be induced in CRS Type 5 mechanism. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | As a result of the first reported incident, in 19765, two supplementary questions were added to form B of the Cremation Act certificate. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, with recent developments in measurement methods, various cytokines such as IL-1β, IL-8, TNF-α, matrix metalloproteinase-8, 9 (MMP-8, 9), and IL-1 receptor agonist are now being further measured. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | (An et al, 2006; Fiore, Jaen, & Baker, May 2008; Zhu et al, 2002) Prior patient navigation studies (K. Lasser et al, 2011; Phillips et al, 2011) have demonstrated how navigators can motivate patients to engage in short-term behavior change such as undergoing a one-time procedure (e.g. colonoscopy or mammogram). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This study was designed as a hospital-based case-control study and may have been affected by selection bias. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | We also observed ethnic differences in BMIz trajectories, with Malay children more likely than Chinese children to have rapid BMIz gain trajectories and Indian children more likely to have stable low BMIz or rapid BMIz gain trajectories. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In contradiction to our results, Berrino et al (1996) found that the odds ratio for oestradiol decreased when adjusted for (free) testosterone, while adjustment for total oestradiol increased the association between breast cancer risk and levels of total testosterone. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In our study using contrast-enhanced whole-heart CMRA at 3.0T in 48 subjects, the CS and PIV were observed in 100% of subjects, the PVLV in 88%, the LMV in 69%, and the AIV in 79%. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This proof of concept creates an avenue for further prospective investigation and refinement. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Furthermore, future studies should also collect data on prior training and exposure to mindfulness activities and emotion regulation strategies. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | With the smaller sample size resulting from missing data, the best-fit LARS regression models may have included more predictors (overfit) than may have been included in a larger sample. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In contrast however, Bock and colleagues observed increased spine densities in layers II/III of parietal, somatosensory cortex (Bock et al, 2005), in Wistar rats, exposed to 1 hour daily separations, for periods ranging either from PND 1-3, 5-7 or 14-16. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Some of these studies focused on different populations, such as participants with a late onset of the disorder, i.e., those who adapted to their biological sex during early life26, or gender dysphoric adolescents38. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | For example, correlations between mean FA and BSID language and cognitive scores were mainly in the corpus callosum (which connects the left and right brain hemisphere and may play an important role in language lateralization [citation]), including the genu, body, and radiation; and in the projection fibers (which transmit neural signal from deep brain to cortex and may be a pathway for the functional integration of motor and cognition [citation]), including the cerebral peduncle and internal capsules. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This study also has some limitations. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, 80% of all THA patients are diagnosed with primary osteoarthritis (Overgaard 2013), so the patients in this trial represent the vast majority of all THA patients. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Addressing this risk may reduce delays due to reluctance to take on this burden, and those due to the need to gather funds. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In the current study, IBS-D patients had decreased mRNA expression of two TJ proteins, ZO-1 and occludin, consistent with prior studies (25, 28). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Among them, rs9267673, rs2647073 and rs3997872 were already shown to be associated with LC in the initial GWAS study9. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Thus, we should always consider cardiorespiratory physiology to be the principal determinant for FiO. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | As one of many major laboratory tests, CRP is primarily used when an obstetrician needs to monitor various inflammatory conditions such as chorioamnionitis [24]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | First, the causality of the associations cannot be determined with the cross-sectional design of our study. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The rate of having a baby under the age of 30 was 82.8% in the previous study; the rate was 76% in partricipants at Arnavutköy and 31% in participants in Şişli in this study. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | It is recognized that screening programs for high-risk populations are urgently needed since almost half of HCV infections are undiagnosed.[Citatipon] Although the US Preventive Services Task Force does not yet recommend annual HCV screening in high-risk populations,[citation] the Veterans Affairs Medical Center (VAMC) encourages yearly screening for people with HCV risk factors.11 Given the high HCV prevalence among the SMI population[citation] adopting VAMC screening practices in public mental health clinics might be worth considering. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The inability to distinguish clusters might be due to the relatively small groups. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In the ambulatory setting, oral anticoagulation, including treatment with direct oral anticoagulants, is feasible. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This study is limited by the restricted number of patients and by the in vitro experimental evaluations. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Studies have shown that the risk of breast cancer can be decreased by about 30% with a young age at first pregnancy, multiple pregnancies and breastfeeding. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Where pediatric standards were unavailable (to quantitatively evaluate vessel wall density and distal ICA mean flow velocity), we tested an age- and gender-matched healthy control cohort, with predictably larger BMI. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Future investigations would benefit from a more inclusive sample and more robust incorporation of levels influential in behavior. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Moreover, nearly all patients in this study who practised self-medication took analgesics only when necessary. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | As discussed in the previous sections, temporal discounting of future rewards (and punishments) is a necessary component in the current framework. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This logic lay behind the elucidation of the impact on obesity of defects in SIM1. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In our opinion it is an effect of laparoscopy in combination with the ERAS protocol. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | This survey showed that one in four of Xinjiang adults aged ≥18 years had hypertension. |
This is a strong advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In cases of severe inflammation with “heparin resistance,” additional monitoring of anti-Xa activity levels (target range: 0.3–0.7 IU/mL) is recommended. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The findings from different ethnicity conducted in the United States showed that the prevalence of hypertension was 40.5% in non-Hispanic blacks, while 27.4% in non-Hispanic whites [31]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Although the low friction arthroplasty is often considered as the gold standard in terms of polyethylene wear, Isaac et al. demonstrated that stainless steel femoral heads became roughened in vivo, mainly by particles of radiographic contrast medium, and assumed that the harder ceramic femoral heads would give a bearing surface which would not be damaged so easily [17]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Future studies should include these scales to support more valid clinical implications. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In comparison with Sanford and Myers [15], who reported superficial infection of the wound in 1.1% of 486 patients after fixateur interne implants, our infection rate (17%) differs significantly. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, this model is not strictly applicable to our study, since our patients, who had adequate gluten exposure in their diets, were not preselected for evidence of gluten intolerance. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Cystatin C, neutrophil gelatinase-associated lipocalin, or those combined in the NephroCheck® could have been used to detect renal failure at an earlier stage and/or with a higher sensitivity 38–40. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Short-term benefits of such modern perioperative care were proved by numerous randomized controlled trials on patients undergoing colon or rectal resections [19,23]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Next, as in most chronic pain research, we assumed that the pain condition is a stressful situation but we did not measure this explicitly which can be seen as a drawback in the study. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In addition, Romero et al. [6] reported correlations among the existence of a placental inflammatory lesion, inflammation level, and choriodecidua inflammation pattern via amniotic fluid culture results and amniotic fluid white blood cell counts, respectively. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In the Norwegian arthroplasty register at 4.5 years 99.1% of the ZweymuÈller Alloclassic-SL stems had not been revised [14]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Two surgical departments (otorhinolaryngology and general surgery) and 11 surgeons performed thyroidectomy in the present study, and each of these clinicians used their preferred method of pain management. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Over the course of the intervention, participants may have learned more standard classification of PA, so that by the final assessment, they reported their PA levels more consistently with these standards. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Our discovery that mice pretreated with ANP exhibited a dramatic reduction of LPS-induced pulmonary metastasis of introduced cancer cells provides direct evidence that ANP can prevent tumor metastasis in mice. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | So far, most research is focused on GDF5 (growth differentiation factor 5) [23,24]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In addition, for several reasons, follow-up information was not available in this study. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Second, all of the outcome measures were assessed on the basis of self-reported responses, which could inflate associations. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | The follow-up period in both these studies was short, with a mean of 3.5 years reported by Berrino et al (1996) and a median of 2.9 years reported by Dorgan et al (1996). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Therefore, the smaller the γ is, the less valuable a given uncertainty reduction is. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | However, the differences in both HOOS and EQ-5D between the 2 approaches were small, and it can be questioned whether the differences are above the minimal clinically important difference (MCID) (Ehrich et al 2000, Roos and Lohmander 2003, Terwee et al 2009, Larsen et al 2010, Roos 2012, Coretti et al 2014). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | There have been no detailed immunophenotypic studies in cohorts of asymptomatic relatives of patients with PAD. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Several large prospective cohort studies have supported the lack of an association between dietary lutein/zeaxanthin intake and CRC36,37. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | As detailed in Table 2 and Figure 2, this biker position was shown here to reduce myocardial attenuation and corresponding artifacts, as compared with the sitting or supine position, with this reduction mainly involving the basal portion of the inferior area, similarly to that previously reported for the prone versus the supine position. |
This is a weak advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Extending such programmes to cover high-cost care would help to mitigate the financial ruin that can stem from acute illness. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Since most predictors of outcome in first-episode psychosis are not modifiable and DUP remained a significant predictor of outcome after adjusting for the effects of many other variables, DUP could prove to be a target for secondary preventive efforts in early psychosis (Harrigan et al, 2003). |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Both patterns of prioritization have been reported in care-seeking for acute febrile illnesses in different contexts [37, 38]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Such maladaptive vascular remodeling would predict lower arterial compliance and impaired flow reserve. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | In most cases, AST and ALT elevations are transient and occur within the first two cycles of treatment. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | Future energy balance interventions could adopt social support strategies from peer provided mental health services—to employ the shared experiences of a condition, but using the changed health behaviors of a peer to promote “recovery” [14]. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | All primary cell cultures expressed significant amounts of angiogenin. |
This is no advice | Question: is this a 2) strong advice, 1) weak advice 0) no advice? | These autopsy studies have described a diffuse arteriopathy marked by striking depletion of vascular smooth muscle cells from media, along with deposition of replacement proteoglycans and collagen in both media and adventitia. |